@article{MonakhovaDiehl2021,
  author    = {Monakhova, Yulia and Diehl, Bernd W. K.},
  title     = {Simplification of NMR Workflows by Standardization Using 2H Integral of Deuterated Solvent as Applied to Aloe vera Preparations},
  series = {Applied Magnetic Resonance},
  volume    = {52},
  journal   = {Applied Magnetic Resonance},
  number    = {11},
  publisher = {Springer},
  address   = {Cham},
  issn      = {1613-7507},
  doi       = {10.1007/s00723-021-01393-4},
  pages     = {1591 -- 1600},
  year      = {2021},
  abstract  = {In this study, a recently proposed NMR standardization approach by 2H integral of deuterated solvent for quantitative multicomponent analysis of complex mixtures is presented. As a proof of principle, the existing NMR routine for the analysis of Aloe vera products was modified. Instead of using absolute integrals of targeted compounds and internal standard (nicotinamide) from 1H-NMR spectra, quantification was performed based on the ratio of a particular 1H-NMR compound integral and 2H-NMR signal of deuterated solvent D2O. Validation characteristics (linearity, repeatability, accuracy) were evaluated and the results showed that the method has the same precision as internal standardization in case of multicomponent screening. Moreover, a dehydration process by freeze drying is not necessary for the new routine. Now, our NMR profiling of A. vera products needs only limited sample preparation and data processing. The new standardization methodology provides an appealing alternative for multicomponent NMR screening. In general, this novel approach, using standardization by 2H integral, benefits from reduced sample preparation steps and uncertainties, and is recommended in different application areas (purity determination, forensics, pharmaceutical analysis, etc.).},
  language  = {en}
}
@article{MolinnusSorichBartzetal.2016,
  author    = {Molinnus, Denise and Sorich, Maren and Bartz, Alexander and Siegert, Petra and Willenberg, Holger S. and Lisdat, Fred and Poghossian, Arshak and Keusgen, Michael and Sch{\"o}ning, Michael Josef},
  title     = {Towards an adrenaline biosensor based on substrate recycling amplification in combination with an enzyme logic gate},
  series = {Sensors and Actuators B: Chemical},
  volume    = {237},
  journal   = {Sensors and Actuators B: Chemical},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0925-4005},
  doi       = {10.1016/j.snb.2016.06.064},
  pages     = {190 -- 195},
  year      = {2016},
  abstract  = {An amperometric biosensor using a substrate recycling principle was realized for the detection of low adrenaline concentrations (1 nM) by measurements in phosphate buffer and Ringer's solution at pH 6.5 and pH 7.4, respectively. In proof-of-concept experiments, a Boolean logic-gate principle has been applied to develop a digital adrenaline biosensor based on an enzyme AND logic gate. The obtained results demonstrate that the developed digital biosensor is capable for a rapid qualitative determination of the presence/absence of adrenaline in a YES/NO statement. Such digital biosensor could be used in clinical diagnostics for the control of a correct insertion of a catheter in the adrenal veins during adrenal venous-sampling procedure.},
  language  = {en}
}
@article{MolinnusMuschallikGonzalezetal.2018,
  author    = {Molinnus, Denise and Muschallik, Lukas and Gonzalez, Laura Osorio and Bongaerts, Johannes and Wagner, Torsten and Selmer, Thorsten and Siegert, Petra and Keusgen, Michael and Sch{\"o}ning, Michael Josef},
  title     = {Development and characterization of a field-effect biosensor for the detection of acetoin},
  series = {Biosensors and Bioelectronics},
  volume    = {115},
  journal   = {Biosensors and Bioelectronics},
  publisher = {Elsevier},
  address   = {Amsterdam},
  doi       = {10.1016/j.bios.2018.05.023},
  pages     = {1 -- 6},
  year      = {2018},
  abstract  = {A capacitive electrolyte-insulator-semiconductor (EIS) field-effect biosensor for acetoin detection has been presented for the first time. The EIS sensor consists of a layer structure of Al/p-Si/SiO₂/Ta₂O₅/enzyme acetoin reductase. The enzyme, also referred to as butane-2,3-diol dehydrogenase from B. clausii DSM 8716T, has been recently characterized. The enzyme catalyzes the (R)-specific reduction of racemic acetoin to (R,R)- and meso-butane-2,3-diol, respectively. Two different enzyme immobilization strategies (cross-linking by using glutaraldehyde and adsorption) have been studied. Typical biosensor parameters such as optimal pH working range, sensitivity, hysteresis, linear concentration range and long-term stability have been examined by means of constant-capacitance (ConCap) mode measurements. Furthermore, preliminary experiments have been successfully carried out for the detection of acetoin in diluted white wine samples.},
  language  = {en}
}
@article{MolinnusBaeckerSiegertetal.2015,
  author    = {Molinnus, Denise and B{\"a}cker, Matthias and Siegert, Petra and Willenberg, H. and Poghossian, Arshak and Keusgen, M. and Sch{\"o}ning, Michael Josef},
  title     = {Detection of Adrenaline Based on Substrate Recycling Amplification},
  series = {Procedia Engineering},
  volume    = {120},
  journal   = {Procedia Engineering},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1877-7058},
  doi       = {10.1016/j.proeng.2015.08.708},
  pages     = {540 -- 543},
  year      = {2015},
  abstract  = {An amperometric enzyme biosensor has been applied for the detection of adrenaline. The adrenaline biosensor has been prepared by modification of an oxygen electrode with the enzyme laccase that operates at a broad pH range between pH 3.5 to pH 8. The enzyme molecules were immobilized via cross-linking with glutaraldehyde. The sensitivity of the developed adrenaline biosensor in different pH buffer solutions has been studied.},
  language  = {en}
}
@article{MichalakNacerddinePietersenetal.2013,
  author    = {Michalak, Ewa Malgorzata and Nacerddine, Karim and Pietersen, Alexandra and Beuger, Vincent and Pawlitzky, Inka and Cornelissen-Steijger, Paulien and Wientjens, Ellen and Tanger, Ellen and Seibler, Jost and Lohuizen, Maarten van and Jonkers, Jos},
  title     = {Polycomb group gene Ezh2 regulates mammary gland morphogenesis and maintains the luminal progenitor pool},
  series = {Stem Cells},
  volume    = {Vol 31},
  journal   = {Stem Cells},
  number    = {9},
  publisher = {Oxford University Press},
  address   = {Oxford},
  issn      = {1549-4918},
  doi       = {10.1002/stem.1437},
  pages     = {1910 -- 1920},
  year      = {2013},
  language  = {en}
}
@article{MeyerStorkHoeckerBerndt1992,
  author    = {Meyer-Stork, L. Sebastian and H{\"o}cker, Hartwig and Berndt, Heinz},
  title     = {Syntheses and reactions of urethanes of cellobiose and cellulose-containing uretdione groups},
  series = {Journal of applied polymer science},
  volume    = {44},
  journal   = {Journal of applied polymer science},
  number    = {6},
  issn      = {1097-4628},
  pages     = {1043 -- 1049},
  year      = {1992},
  language  = {en}
}
@article{MeyerHentschkeHageretal.2017,
  author    = {Meyer, Jan and Hentschke, Reinhard and Hager, Jonathan and Hojdis, Nils and Karimi-Varzaneh, Hossein Ali},
  title     = {Molecular Simulation of Viscous Dissipation due to Cyclic Deformation of a Silica-Silica Contact in Filled Rubber},
  series = {Macromolecules},
  volume    = {50},
  journal   = {Macromolecules},
  number    = {17},
  issn      = {1520-5835},
  doi       = {10.1021/acs.macromol.7b00947},
  pages     = {6679 -- 6689},
  year      = {2017},
  language  = {en}
}
@article{MerschenzQuackMootz1988,
  author    = {Merschenz-Quack, Angelika and Mootz, D.},
  title     = {Structures of sulfuryl halides: SO2F2, SO2CIF and SO2Cl2 / Mootz, D. ; Merschenz-Quack, A.},
  series = {Acta crystallographica / Section C, Crystal structure communications. C 44 (1988), H. 5},
  journal   = {Acta crystallographica / Section C, Crystal structure communications. C 44 (1988), H. 5},
  isbn      = {0108-2701},
  pages     = {924 -- 925},
  year      = {1988},
  language  = {en}
}
@article{MerschenzQuackMootz1990,
  author    = {Merschenz-Quack, Angelika and Mootz, D.},
  title     = {Structure of 5-sulfosalicylic acid pentahydrate},
  series = {Acta crystallographica / Section C, Crystal structure communications. C 46 (1990), H. 8},
  journal   = {Acta crystallographica / Section C, Crystal structure communications. C 46 (1990), H. 8},
  isbn      = {0108-2701},
  pages     = {1478 -- 1480},
  year      = {1990},
  language  = {en}
}
@article{MerschenzQuackMootz1988,
  author    = {Merschenz-Quack, Angelika and Mootz, D.},
  title     = {Structures of thionyl halides: SOCl2 and SOBr2 / Mootz, D. ; Merschenz-Quack, A.},
  series = {Acta crystallographica / Section C, Crystal structure communications. C 44 (1988), H. 5},
  journal   = {Acta crystallographica / Section C, Crystal structure communications. C 44 (1988), H. 5},
  isbn      = {0108-2701},
  pages     = {926 -- 927},
  year      = {1988},
  language  = {en}
}
@article{MerschenzQuackHemmerlingWunderlich2004,
  author    = {Merschenz-Quack, Angelika and Hemmerling, Hans-J{\"o}rg and Wunderlich, Hartmut},
  title     = {1,2-Deoxygenation of vic-Dihydroxyindenoimidazoles: Optimization of a Novel Deoxygenation Reagent. I. / Hemmerling, Hans-J{\"o}rg ; Merschenz-Quack, Angelika ; Wunderlich, Hartmut},
  series = {Zeitschrift f{\"u}r Naturforschung B. 59 (2004), H. 10},
  journal   = {Zeitschrift f{\"u}r Naturforschung B. 59 (2004), H. 10},
  isbn      = {0932-0776},
  pages     = {1143 -- 1152},
  year      = {2004},
  language  = {en}
}
@article{MedlinLangeBaumann1994,
  author    = {Medlin, L. K. and Lange, M. and Baumann, Marcus},
  title     = {Genetic differentiation among three colony-forming species of Phaeocystis : further evidence for the phylogeny of the Prymnesiophyta},
  series = {Phycologia},
  volume    = {Vol. 33},
  journal   = {Phycologia},
  number    = {Iss. 3},
  issn      = {0031-8884},
  pages     = {199 -- 212},
  year      = {1994},
  language  = {en}
}
@article{MayerHentschkeHageretal.2017,
  author    = {Mayer, Jan and Hentschke, Reinhard and Hager, Jonathan and Hojdis, Nils and Karimi-Varnaneh, Hossein Ali},
  title     = {A Nano-Mechanical Instability as Primary Contribution to Rolling Resistance},
  series = {Scientific Reports},
  volume    = {7},
  journal   = {Scientific Reports},
  number    = {Article number 11275},
  publisher = {Springer},
  address   = {Berlin},
  issn      = {2045-2322},
  year      = {2017},
  language  = {en}
}
@article{MatoniBerndt1980,
  author    = {Matoni, Georg and Berndt, Heinz},
  title     = {Thermal synthesis of the optical pure pentapeptide derivative Z-(L)-Ala-(L)-Phe-Gly-(L)-Phe-Gly-OMe},
  series = {Tetrahedron letters},
  volume    = {21},
  journal   = {Tetrahedron letters},
  number    = {1},
  issn      = {0040-4039},
  doi       = {10.1016/S0040-4039(00)93618-9},
  pages     = {37 -- 40},
  year      = {1980},
  language  = {en}
}
@article{MartinsBlaserFeliksetal.2011,
  author    = {Martins, Berta M. and Blaser, Martin and Feliks, Mikolaj and Ullmann, Matthias G. and Buckel, Wolfgang and Selmer, Thorsten},
  title     = {Structural basis for a Kolbe-type decarboxylation catalyzed by a glycyl radical enzyme},
  series = {Journal of the American Chemical Society},
  journal   = {Journal of the American Chemical Society},
  publisher = {ACS Publications},
  address   = {Washington, DC},
  pages     = {1 -- 33},
  year      = {2011},
  language  = {en}
}
@article{MartinezJakobTuetal.2013,
  author    = {Martinez, Ronny and Jakob, Felix and Tu, Ran and Siegert, Petra and Maurer, Karl-Heinz and Schwaneberg, Ulrich},
  title     = {Increasing activity and thermal resistance of Bacillus gibsonii alkaline protease (BgAP) by directed evolution},
  series = {Biotechnology and bioengineering},
  volume    = {Vol. 110},
  journal   = {Biotechnology and bioengineering},
  number    = {Iss. 3},
  publisher = {Wiley},
  address   = {Weinheim},
  issn      = {1097-0290 (E-Journal); 0006-3592 (Print); 0368-1467 (Print)},
  pages     = {711 -- 720},
  year      = {2013},
  language  = {en}
}
@article{MangRoosenAnsorgeSchumacheretal.2007,
  author    = {Mang, Thomas and Roosen, Christoph and Ansorge-Schumacher, Marion and Leitner, Walter},
  title     = {Gaining pH-control in water/carbon dioxide biphasic systems / Roosen, Christoph ; Ansorge-Schumacher, Marion ; Mang, Thomas ; Leitner, Walter ; Greiner, Lasse},
  series = {Green Chemistry. 9 (2007)},
  journal   = {Green Chemistry. 9 (2007)},
  isbn      = {1463-9262},
  pages     = {455 -- 458},
  year      = {2007},
  language  = {en}
}
@article{MangRoosenAnsorgeetal.2006,
  author    = {Mang, Thomas and Roosen, C. and Ansorge, Marion and Leitner, W.},
  title     = {Gaining pH-control in water/carbon dioxide biphasic systems / Abstract No. 1038 / Roosen, Ch. ; Ansorge, M. ; Mang, Thomas ; Leitner, W. ; Greiner, L.},
  series = {Green solvents for processes : Lake Constance, Friedrichshafen, Germany, 8 - 11 October 2006 ; book of abstracts / DECHEMA e.V.},
  journal   = {Green solvents for processes : Lake Constance, Friedrichshafen, Germany, 8 - 11 October 2006 ; book of abstracts / DECHEMA e.V.},
  publisher = {DECHEMA},
  address   = {Frankfurt am Main},
  pages     = {145 S.},
  year      = {2006},
  language  = {en}
}
@article{MangKricheldorfJonte1984,
  author    = {Mang, Thomas and Kricheldorf, Hans R. and Jont{\´e}, J. Michael},
  title     = {Polylactones. 1. Copolymerizations of glycolide and \&beta-caprolactone / Kricheldorf, Hans R. ; Mang, Thomas ; Jont{\´e}, J. Michael},
  series = {Macromolecules. 17 (1984), H. 10},
  journal   = {Macromolecules. 17 (1984), H. 10},
  isbn      = {0024-9297},
  pages     = {2173 -- 2181},
  year      = {1984},
  language  = {en}
}
@article{MangKricheldorfJonte1985,
  author    = {Mang, Thomas and Kricheldorf, Hans R. and Jont{\´e}, J. Michael},
  title     = {Polylactones, 2. Copolymerization of glycolide with \&\#946;-propiolactone, \&\#967;-butyrolactone or \&\#948;-valerolactone / Kricheldorf, Hans R. ; Mang, Thomas ; Jont{\´e}, J. Michael},
  series = {Die makromolekulare Chemie. 186 (1985), H. 5},
  journal   = {Die makromolekulare Chemie. 186 (1985), H. 5},
  isbn      = {1022-1352},
  pages     = {955 -- 976},
  year      = {1985},
  language  = {en}
}
@article{MangKricheldorfAu1985,
  author    = {Mang, Thomas and Kricheldorf, Hans R. and Au, M.},
  title     = {Models of molecular evolution. 2. Stereospecificity of dipeptide syntheses by means of cyanamides and carbodiimides / Kricheldorf, Hans R. ; Au, M. ; Mang, Thomas},
  series = {International journal of peptide and protein research. 26 (1985), H. 2},
  journal   = {International journal of peptide and protein research. 26 (1985), H. 2},
  isbn      = {0300-9769},
  pages     = {149 -- 157},
  year      = {1985},
  language  = {en}
}
@article{MangKricheldorf1983,
  author    = {Mang, Thomas and Kricheldorf, Hans R.},
  title     = {Stereospecificity of peptide synthesis by means of phosphorus derivatives: a model of peptide synthesis in molecular evolution / Kricheldorf, Hans R. ; Mang, Thomas},
  series = {International Journal of Biological Macromolecules. 5 (1983), H. 5},
  journal   = {International Journal of Biological Macromolecules. 5 (1983), H. 5},
  isbn      = {0141-8130},
  pages     = {258 -- 266},
  year      = {1983},
  language  = {en}
}
@article{MangKricheldorf1981,
  author    = {Mang, Thomas and Kricheldorf, Hans R.},
  title     = {13-C-NMR Sequence Analysis 20. Stereospecificity of the polymerization of D,L-Leu-NCA and D,L-Val-NCA / Kricheldorf, Hans R. ; Mang, Thomas},
  series = {Die makromolekulare Chemie. 182 (1981), H. 11},
  journal   = {Die makromolekulare Chemie. 182 (1981), H. 11},
  isbn      = {1022-1352},
  pages     = {3077 -- 3098},
  year      = {1981},
  language  = {en}
}
@article{MangKricheldorf1982,
  author    = {Mang, Thomas and Kricheldorf, Hans R.},
  title     = {13-C-NMR sequence analysis. 21. Stereoselectivity of oligopeptide syntheses / Kricheldorf, Hans R. ; Mang, Thomas},
  series = {Die makromolekulare Chemie. 183 (1982), H. 9},
  journal   = {Die makromolekulare Chemie. 183 (1982), H. 9},
  isbn      = {1022-1352},
  pages     = {2093 -- 2111},
  year      = {1982},
  language  = {en}
}
@article{MangKricheldorf1982,
  author    = {Mang, Thomas and Kricheldorf, Hans R.},
  title     = {13-C-NMR sequence analysis. 22. Stereoselectivity of the polymerization of D,L-leucine and D,L-valine N-thiocarboxy anhydrides / Kricheldorf, Hans R. ; Mang, Thomas},
  series = {Die makromolekulare Chemie. 183 (1982), H. 9},
  journal   = {Die makromolekulare Chemie. 183 (1982), H. 9},
  isbn      = {1022-1352},
  pages     = {2113 -- 2129},
  year      = {1982},
  language  = {en}
}
@article{MangKolzMartinsetal.2007,
  author    = {Mang, Thomas and Kolz, J. and Martins, J. and Kremer, K.},
  title     = {Investigation of the Elastomer-Foam Production with Single-Sided NMR / Kolz, J. ; Martins, J. ; Kremer, K. ; Mang, Thomas ; Bl{\"u}mich, B.},
  series = {Kautschuk Gummi Kunststoffe. 60 (2007), H. 4},
  journal   = {Kautschuk Gummi Kunststoffe. 60 (2007), H. 4},
  isbn      = {0948-3276},
  pages     = {179 -- 183},
  year      = {2007},
  language  = {en}
}
@article{MangKolzMartinsetal.2006,
  author    = {Mang, Thomas and Kolz, J. and Martins, J. and Kremer, K.},
  title     = {Investigation of Elastomer Foams by Single-Sided NMR / Kolz, J. ; Martins, J. ; Kremer, K. ; Bl{\"u}mich, B. ; Mang, Thomas},
  series = {Kurzfassungen : 3. bis 6. Juli 2006, N{\"u}rnberg = Summaries / Deutsche Kautschuk Tagung, 3.7.-6.7.2006},
  journal   = {Kurzfassungen : 3. bis 6. Juli 2006, N{\"u}rnberg = Summaries / Deutsche Kautschuk Tagung, 3.7.-6.7.2006},
  publisher = {DKG, Dt. Kautschuk-Ges.},
  address   = {Frankfurt, Main},
  pages     = {33},
  year      = {2006},
  language  = {en}
}
@article{MangKolzHungeretal.2007,
  author    = {Mang, Thomas and Kolz, J. and Hunger, K. and Rath, S.},
  title     = {Investigation of self-diffusion processes in ionic hydrogels with a single-sided sensor / Kolz, J. ; Hunger, K. ; Rath, S. ; Mang, T. ; Bl{\"u}mich, B.},
  series = {Magnetic Resonance Imaging. 25 (2007), H. 4},
  journal   = {Magnetic Resonance Imaging. 25 (2007), H. 4},
  isbn      = {0730-725X},
  pages     = {566 -- 567},
  year      = {2007},
  language  = {en}
}
@article{MangKolzGogaetal.2007,
  author    = {Mang, Thomas and Kolz, J. and Goga, N. and Casanova, F.},
  title     = {Spatial localization with single-sided NMR sensors / Kolz, J. ; Goga, N. ; Casanova, F. ; Mang, T. ; Bl{\"u}mich, B.},
  series = {Applied Magnetic Resonance. 32 (2007), H. 1-2},
  journal   = {Applied Magnetic Resonance. 32 (2007), H. 1-2},
  isbn      = {0937-9347},
  pages     = {171 -- 184},
  year      = {2007},
  language  = {en}
}
@article{MangHodeniusSchmitzRodeetal.2009,
  author    = {Mang, Thomas and Hodenius, M. A. J. and Schmitz-Rode, T. and Baumann, M.},
  title     = {Absorption of 10-hydroxycamptothecin into the coat of magnetoliposomes / Hodenius, M. A. J. ; Schmitz-Rode, T. ; Baumann, M. ; Ivoanova, G. ; Wong, J. E. ; Mang, T. ; Haulena, F. ; Soenen, S. J. H. ; De Cuyper, M.},
  series = {Colloids and Surfaces A: Physicochemical and Engineering Aspects. 343 (2009), H. 1-3},
  journal   = {Colloids and Surfaces A: Physicochemical and Engineering Aspects. 343 (2009), H. 1-3},
  publisher = {Elsevier},
  address   = {Amsterdam},
  isbn      = {0927-7757},
  pages     = {20 -- 23},
  year      = {2009},
  language  = {en}
}
@article{MangHaulena1992,
  author    = {Mang, Thomas and Haulena, Friedhelm},
  title     = {Monodisperse latex particles with functional groups},
  series = {Modification of polymers : 4th Dresden Polymer Discussion ; September 22 to 25, 1992 at Gaussig / Dresden University of Technology, Department of Macromolecular Chemistry and Textile Chemistry; Institute of Polymer Technology Dresden. [Organizers: Claudia Kummerl{\"o}we ...]},
  journal   = {Modification of polymers : 4th Dresden Polymer Discussion ; September 22 to 25, 1992 at Gaussig / Dresden University of Technology, Department of Macromolecular Chemistry and Textile Chemistry; Institute of Polymer Technology Dresden. [Organizers: Claudia Kummerl{\"o}we ...]},
  publisher = {Univ.},
  address   = {Dresden},
  pages     = {68 -- 88},
  year      = {1992},
  language  = {en}
}
@article{MangHaulena1998,
  author    = {Mang, Thomas and Haulena, Friedhelm},
  title     = {Recycling of Polymeric Composites},
  series = {Invited and contributing lectures presented at the 38th Microsymposium on Recycling of Polymers : held in Prague, Czech Republic, July 14 - 17, 1997 / International Union of Pure and Applied Chemistry, Macromolecular Division. Symposium ed. J. Kahovec.},
  journal   = {Invited and contributing lectures presented at the 38th Microsymposium on Recycling of Polymers : held in Prague, Czech Republic, July 14 - 17, 1997 / International Union of Pure and Applied Chemistry, Macromolecular Division. Symposium ed. J. Kahovec.},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  pages     = {147 -- 156},
  year      = {1998},
  language  = {en}
}
@article{Mang2004,
  author    = {Mang, Thomas},
  title     = {Thermosensitive Magnetic Nanoparticles for Bioanalytical and Therapeutical Applications},
  series = {Biomedizinische Technik = Biomedical Engineering. 49 (2004), H. 2},
  journal   = {Biomedizinische Technik = Biomedical Engineering. 49 (2004), H. 2},
  isbn      = {0013-5585},
  pages     = {1006 -- 1007},
  year      = {2004},
  language  = {en}
}
@article{Mang2004,
  author    = {Mang, Thomas},
  title     = {Polymer Magnetic Particles for Isolating Biomolecules, Especially Nucleic Acids},
  series = {Biomedizinische Technik = Biomedical Engineering. 49 (2004), H. 2},
  journal   = {Biomedizinische Technik = Biomedical Engineering. 49 (2004), H. 2},
  isbn      = {0013-5585},
  pages     = {1008 -- 1009},
  year      = {2004},
  language  = {en}
}
@article{ManeaLeursOrbanetal.2011,
  author    = {Manea, Marilena and Leurs, Ulrike and Orban, Erika and Baranyai, Zsuzsa and {\"O}hlschl{\"a}ger, Peter and Marquardt, Andreas and Schulcz, Akos and Tejeda, Miguel},
  title     = {Enhanced Enzymatic Stability and Antitumor Activity of Daunorubicin-GnRH-III Bioconjugates Modified in Position 4},
  series = {Bioconjugate Chemistry},
  volume    = {22},
  journal   = {Bioconjugate Chemistry},
  number    = {7},
  publisher = {ACS},
  address   = {Washington, DC},
  isbn      = {1520-4812},
  pages     = {1320 -- 1329},
  year      = {2011},
  language  = {en}
}
@article{MaggakisKelemenBorkKayseretal.2003,
  author    = {Maggakis-Kelemen, C. and Bork, M. and Kayser, Peter and Biselli, Manfred and Artmann, Gerhard},
  title     = {Biological and mechanical quality of red blood cells cultured from human umbilical cord blood stem cells},
  series = {Medical and biological engineering and computing. 41 (2003), H. 3},
  journal   = {Medical and biological engineering and computing. 41 (2003), H. 3},
  isbn      = {0140-0118},
  pages     = {350 -- 356},
  year      = {2003},
  language  = {en}
}
@article{LuisierLempiaeinenScherbichleretal.2014,
  author    = {Luisier, Rapha{\"e}lle and Lempi{\"a}inen, Harri and Scherbichler, Nina and Braeuning, Albert and Geissler, Miriam and Dubost, Valerie and M{\"u}ller, Arne and Scheer, Nico and Chibout, Salah-Dine and Hara, Hisanori and Picard, Frank and Theil, Diethilde and Couttet, Philippe and Vitobello, Antonio and Grenet, Olivier and Grasl-Kraupp, Bettina and Ellinger-Ziegelbauer, Heidrung and Thomson, John P. and Meehan, Richard R. and Elcombe, Clifford R. and Henderson, Colin J. and Wolf, C. Roland and Schwarz, Michael and Moulin, Pierre and Terranova, Remi and Moggs, Jonathan G.},
  title     = {Phenobarbital Induces Cell Cycle Transcriptional Responses in Mouse Liver Humanized for Constitutive Androstane and Pregnane X Receptors},
  series = {Toxicological Sciences},
  volume    = {139},
  journal   = {Toxicological Sciences},
  number    = {2},
  publisher = {Oxford University Press},
  address   = {Oxford},
  issn      = {1094-2025},
  doi       = {https://doi.org/10.1093/toxsci/kfu038},
  pages     = {501 -- 511},
  year      = {2014},
  abstract  = {The constitutive androstane receptor (CAR) and the pregnane X receptor (PXR) are closely related nuclear receptors involved in drug metabolism and play important roles in the mechanism of phenobarbital (PB)-induced rodent nongenotoxic hepatocarcinogenesis. Here, we have used a humanized CAR/PXR mouse model to examine potential species differences in receptor-dependent mechanisms underlying liver tissue molecular responses to PB. Early and late transcriptomic responses to sustained PB exposure were investigated in liver tissue from double knock-out CAR and PXR (CARᴷᴼ-PXRᴷᴼ), double humanized CAR and PXR (CARʰ-PXRʰ), and wild-type C57BL/6 mice. Wild-type and CARʰ-PXRʰ mouse livers exhibited temporally and quantitatively similar transcriptional responses during 91 days of PB exposure including the sustained induction of the xenobiotic response gene Cyp2b10, the Wnt signaling inhibitor Wisp1, and noncoding RNA biomarkers from the Dlk1-Dio3 locus. Transient induction of DNA replication (Hells, Mcm6, and Esco2) and mitotic genes (Ccnb2, Cdc20, and Cdk1) and the proliferation-related nuclear antigen Mki67 were observed with peak expression occurring between 1 and 7 days PB exposure. All these transcriptional responses were absent in CARᴷᴼ-PXRᴷᴼ mouse livers and largely reversible in wild-type and CARʰ-PXRʰ mouse livers following 91 days of PB exposure and a subsequent 4-week recovery period. Furthermore, PB-mediated upregulation of the noncoding RNA Meg3, which has recently been associated with cellular pluripotency, exhibited a similar dose response and perivenous hepatocyte-specific localization in both wild-type and CARʰ-PXRʰ mice. Thus, mouse livers coexpressing human CAR and PXR support both the xenobiotic metabolizing and the proliferative transcriptional responses following exposure to PB.},
  language  = {en}
}
@article{LowisFergusonPaulssenetal.2021,
  author    = {Lowis, Carsten and Ferguson, Simon and Paulßen, Elisabeth and Hoehr, Cornelia},
  title     = {Improved Sc-44 production in a siphon-style liquid target on a medical cyclotron},
  series = {Applied Radiation and Isotopes},
  volume    = {172},
  journal   = {Applied Radiation and Isotopes},
  number    = {Art. 109675},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0969-8043},
  doi       = {10.1016/j.apradiso.2021.109675},
  year      = {2021},
  language  = {en}
}
@article{LiuSchaapBallemansetal.2017,
  author    = {Liu, Z. and Schaap, K. S. and Ballemans, L. and de Blois, E. and Rohde, M. and Paulßen, Elisabeth},
  title     = {Measurement of reaction kinetics of [177Lu]Lu-DOTA-TATE using a microfluidic system},
  series = {Dalton Transactions},
  volume    = {46},
  journal   = {Dalton Transactions},
  number    = {42},
  issn      = {1477-9234},
  doi       = {10.1039/C7DT01830D},
  pages     = {14669 -- 14676},
  year      = {2017},
  language  = {en}
}
@article{LindnerBurgerRutledgeetal.2022,
  author    = {Lindner, Simon and Burger, Ren{\´e} and Rutledge, Douglas N. and Do, Xuan Tung and Rumpf, Jessica and Diehl, Bernd W. K. and Schulze, Margit and Monakhova, Yulia},
  title     = {Is the calibration transfer of multivariate calibration models between high- and low-field NMR instruments possible? A case study of lignin molecular weight},
  series = {Analytical chemistry},
  volume    = {94},
  journal   = {Analytical chemistry},
  number    = {9},
  publisher = {ACS Publications},
  address   = {Washington, DC},
  isbn      = {1520-6882},
  doi       = {10.1021/acs.analchem.1c05125},
  pages     = {3997 -- 4004},
  year      = {2022},
  abstract  = {Although several successful applications of benchtop nuclear magnetic resonance (NMR) spectroscopy in quantitative mixture analysis exist, the possibility of calibration transfer remains mostly unexplored, especially between high- and low-field NMR. This study investigates for the first time the calibration transfer of partial least squares regressions [weight average molecular weight (Mw) of lignin] between high-field (600 MHz) NMR and benchtop NMR devices (43 and 60 MHz). For the transfer, piecewise direct standardization, calibration transfer based on canonical correlation analysis, and transfer via the extreme learning machine auto-encoder method are employed. Despite the immense resolution difference between high-field and low-field NMR instruments, the results demonstrate that the calibration transfer from high- to low-field is feasible in the case of a physical property, namely, the molecular weight, achieving validation errors close to the original calibration (down to only 1.2 times higher root mean square errors). These results introduce new perspectives for applications of benchtop NMR, in which existing calibrations from expensive high-field instruments can be transferred to cheaper benchtop instruments to economize.},
  language  = {en}
}
@article{LeursMezoOehlschlaegeretal.2012,
  author    = {Leurs, Ulrike and Mezo, Gabor and {\"O}hlschl{\"a}ger, Peter and Orban, Erika and Marquard, Andrea and Manea, Marilena},
  title     = {Design, synthesis, in vitro stability and cytostatic effect of multifunctional anticancer drug-bioconjugates containing GnRH-III as a targeting moiety},
  series = {Peptide Science},
  volume    = {98},
  journal   = {Peptide Science},
  number    = {1},
  publisher = {Wiley},
  address   = {New York, NY},
  issn      = {1097-0282},
  doi       = {10.1002/bip.21640},
  pages     = {1 -- 10},
  year      = {2012},
  abstract  = {Bioconjugates containing the GnRH-III hormone decapeptide as a targeting moiety are able to deliver chemotherapeutic agents specifically to cancer cells expressing GnRH receptors, thereby increasing their local efficacy while limiting the peripheral toxicity. However, the number of GnRH receptors on cancer cells is limited and they desensitize under continuous hormone treatment. A possible approach to increase the receptor mediated tumor targeting and consequently the cytostatic effect of the bioconjugates would be the attachment of more than one chemotherapeutic agent to one GnRH-III molecule. Here we report on the design, synthesis and biochemical characterization of multifunctional bioconjugates containing GnRH-III as a targeting moiety and daunorubicin as a chemotherapeutic agent. Two different drug design approaches were pursued. The first one was based on the bifunctional [4Lys]-GnRH-III (Glp-His-Trp-Lys-His-Asp-Trp-Lys-Pro-Gly-NH2) containing two lysine residues in positions 4 and 8, whose ϵ-amino groups were used for the coupling of daunorubicin. In the second drug design, the native GnRH-III (Glp-His-Trp-Ser-His-Asp-Trp-Lys-Pro-Gly-NH2) was used as a scaffold; an additional lysine residue was coupled to the ϵ-amino group of 8Lys in order to generate two free amino groups available for conjugation of daunorubicin. The in vitro stability/degradation of all synthesized compounds was investigated in human serum, as well as in the presence of rat liver lysosomal homogenate. Their cellular uptake was determined on human breast cancer cells and the cytostatic effect was evaluated on human breast, colon and prostate cancer cell lines. Compared with a monofunctional compound, both drug design approaches resulted in multifunctional bioconjugates with increased cytostatic effect.},
  language  = {en}
}
@article{LempiaeinenCouttetBolognanietal.2012,
  author    = {Lempi{\"a}inen, Harri and Couttet, Philippe and Bolognani, Federico and M{\"u}ller, Arne and Dubost, Val{\´e}rie and Luisier, Rapha{\"e}lle and Rio-Espinola, Alberto del and Vitry, Veronique and Unterberger, Elif B. and Thomson, John P. and Treindl, Fridolin and Metzger, Ute and Wrzodek, Clemens and Hahne, Florian and Zollinger, Tulipan and Brasa, Sarah and Kalteis, Magdalena and Marcellin, Magali and Giudicelli, Fanny and Braeuning, Albert and Morawiec, Laurent and Zamurovic, Natasa and L{\"a}ngle, Ulrich and Scheer, Nico and Sch{\"u}beler, Dirk and Goodman, Jay and Chibout, Salah-Dine and Marlowe, Jennifer and Theil, Dietlinde and Heard, David J. and Grenet, Olivier and Zell, Andreas and Templin, Markus F. and Meehan, Richard R. and Wolf, Roland C. and Elcombe, Clifford R. and Schwarz, Michael and Moulin, Pierre and Terranova, R{\´e}mi and Moggs, Jonathan G.},
  title     = {Identification of Dlk1-Dio3 imprinted gene cluster non-coding RNAs as novel candidate biomarkers for liver tumor promotion},
  series = {Toxicological Sciences},
  volume    = {131},
  journal   = {Toxicological Sciences},
  number    = {2},
  publisher = {Oxford University Press},
  address   = {Oxford},
  issn      = {1094-2025},
  doi       = {10.1093/toxsci/kfs303},
  pages     = {375 -- 386},
  year      = {2012},
  abstract  = {The molecular events during nongenotoxic carcinogenesis and their temporal order are poorly understood but thought to include long-lasting perturbations of gene expression. Here, we have investigated the temporal sequence of molecular and pathological perturbations at early stages of phenobarbital (PB) mediated liver tumor promotion in vivo. Molecular profiling (mRNA, microRNA [miRNA], DNA methylation, and proteins) of mouse liver during 13 weeks of PB treatment revealed progressive increases in hepatic expression of long noncoding RNAs and miRNAs originating from the Dlk1-Dio3 imprinted gene cluster, a locus that has recently been associated with stem cell pluripotency in mice and various neoplasms in humans. PB induction of the Dlk1-Dio3 cluster noncoding RNA (ncRNA) Meg3 was localized to glutamine synthetase-positive hypertrophic perivenous hepatocytes, sug- gesting a role for β-catenin signaling in the dysregulation of Dlk1-Dio3 ncRNAs. The carcinogenic relevance of Dlk1-Dio3 locus ncRNA induction was further supported by in vivo genetic dependence on constitutive androstane receptor and β-catenin pathways. Our data identify Dlk1-Dio3 ncRNAs as novel candidate early biomarkers for mouse liver tumor promotion and provide new opportunities for assessing the carcinogenic potential of novel compounds.},
  language  = {en}
}
@article{LawsonScheerPhametal.2001,
  author    = {Lawson, Nathan D. and Scheer, Nico and Pham, Van N. and Kim, Ceol-Hee and Chitnis, Ajay B. and Campos-Ortega, Jos{\´e} A. and Weinstein, Brant M.},
  title     = {Notch signaling is required for arterial-venous differentiation during embryonic vascular development},
  series = {Development},
  volume    = {128},
  journal   = {Development},
  number    = {19},
  issn      = {1477-9129},
  pages     = {3675 -- 3683},
  year      = {2001},
  language  = {en}
}
@article{LauthSolomunHirschwaldetal.1989,
  author    = {Lauth, Jakob and Solomun, T. and Hirschwald, W. and Christmann, K.},
  title     = {The interaction of carbon monoxide with a ruthenium(1010) surface},
  series = {Surface Science. 210 (1989), H. 1-2},
  journal   = {Surface Science. 210 (1989), H. 1-2},
  isbn      = {0039-6028},
  pages     = {201 -- 224},
  year      = {1989},
  language  = {en}
}
@article{LauthSolomunHirschwaldetal.1989,
  author    = {Lauth, Jakob and Solomun, T. and Hirschwald, W. and Christmann, K.},
  title     = {The interaction of carbon monoxide with a ruthenium(1010) surface},
  series = {Surface Science Letters. 210 (1989), H. 1-2},
  journal   = {Surface Science Letters. 210 (1989), H. 1-2},
  isbn      = {0167-2584},
  pages     = {A74 -- A75},
  year      = {1989},
  language  = {en}
}
@article{LauthHoelderichWagenblast1995,
  author    = {Lauth, Jakob and Hoelderich, W. and Wagenblast, G.},
  title     = {Molecular sieves containing azo dyes},
  series = {Zeolites. 15 (1995), H. 2},
  journal   = {Zeolites. 15 (1995), H. 2},
  isbn      = {0144-2449},
  pages     = {184},
  year      = {1995},
  language  = {en}
}
@article{LauthHoelderichWagenblast1995,
  author    = {Lauth, Jakob and Hoelderich, W. and Wagenblast, G.},
  title     = {Crystalline zeolites containing indigo dyes},
  series = {Zeolites. 15 (1995), H. 1},
  journal   = {Zeolites. 15 (1995), H. 1},
  isbn      = {0144-2449},
  pages     = {86},
  year      = {1995},
  language  = {en}
}
@article{LauthChristmannSchwarz1990,
  author    = {Lauth, Jakob and Christmann, K. and Schwarz, E.},
  title     = {Adsorption geometry of H on RU(1010) image as determined by LEED and HREELS / Christmann, K. ; Lauth, G. ; Schwarz, E.},
  series = {Vacuum. 41 (1990), H. 1-3},
  journal   = {Vacuum. 41 (1990), H. 1-3},
  isbn      = {0042-207X},
  pages     = {293 -- 296},
  year      = {1990},
  language  = {en}
}
@article{LassonczykVoigtGabrieletal.1990,
  author    = {Lassonczyk, Beate and Voigt, B. and Gabriel, B. and Ghod, Mumin M.},
  title     = {Quaternary events at the Horn of Africa / Voigt, B., B. Gabriel, B. Lassonczyk and Mumin M. Ghod},
  series = {Berliner geowissenschaftliche Abhandlungen / Reihe A, Geologie und Pal{\"a}ontologie / hrsg. von d. Geowissenschaftlichen Instituten der Freien u. d. Technischen Universit{\"a}t Berlin. 120 A (1990)},
  journal   = {Berliner geowissenschaftliche Abhandlungen / Reihe A, Geologie und Pal{\"a}ontologie / hrsg. von d. Geowissenschaftlichen Instituten der Freien u. d. Technischen Universit{\"a}t Berlin. 120 A (1990)},
  isbn      = {0172-8784},
  pages     = {679 -- 694},
  year      = {1990},
  language  = {en}
}
@article{LassonczykAlailyHuthetal.1990,
  author    = {Lassonczyk, Beate and Alaily, F. and Huth, A. and Gensior, A.},
  title     = {Genesis of soils in the arid part of northeast Somalia / F. Alaily, B. Lassonczyk, A.Huth and A. Gensior},
  series = {Berliner geowissenschaftliche Abhandlungen / Reihe A, Geologie und Pal{\"a}ontologie / hrsg. von d. Geowissenschaftlichen Instituten der Freien u. d. Technischen Universit{\"a}t Berlin. 120 A (1990)},
  journal   = {Berliner geowissenschaftliche Abhandlungen / Reihe A, Geologie und Pal{\"a}ontologie / hrsg. von d. Geowissenschaftlichen Instituten der Freien u. d. Technischen Universit{\"a}t Berlin. 120 A (1990)},
  isbn      = {0172-8784},
  pages     = {695 -- 711},
  year      = {1990},
  language  = {en}
}
@article{Lassonczyk1990,
  author    = {Lassonczyk, Beate},
  title     = {Characteristics of a fossil soil developed on the basement complex in the northeast Somalia},
  series = {Berliner geowissenschaftliche Abhandlungen / Reihe A, Geologie und Pal{\"a}ontologie / hrsg. von d. Geowissenschaftlichen Instituten der Freien u. d. Technischen Universit{\"a}t Berlin. 120 A (1990)},
  journal   = {Berliner geowissenschaftliche Abhandlungen / Reihe A, Geologie und Pal{\"a}ontologie / hrsg. von d. Geowissenschaftlichen Instituten der Freien u. d. Technischen Universit{\"a}t Berlin. 120 A (1990)},
  isbn      = {0172-8784},
  pages     = {713 -- 718},
  year      = {1990},
  language  = {en}
}
@article{KueppersSteffenHellmuthetal.2014,
  author    = {K{\"u}ppers, Tobias and Steffen, Victoria and Hellmuth, Hendrik and O'Connell, Timothy and Bongaerts, Johannes and Maurer, Karl-Heinz and Wiechert, Wolfgang},
  title     = {Developing a new production host from a blueprint: Bacillus pumilus as an industrial enzyme producer},
  series = {Microbial cell factories},
  volume    = {13},
  journal   = {Microbial cell factories},
  publisher = {BioMed Central},
  address   = {London},
  issn      = {1475-2859 (E-Journal)},
  doi       = {10.1186/1475-2859-13-46},
  pages     = {Article No. 46},
  year      = {2014},
  language  = {en}
}
@article{KuropkaMuellerHoeckeretal.1989,
  author    = {Kuropka, Rolf and M{\"u}ller, Bettina and H{\"o}cker, Hartwig and Berndt, Heinz},
  title     = {Chiral stationary phases via hydrosilylation reaction of N-acryloylamino acids : I. Stationary phase with one chiral centre for high-performance liquid chromatography and development of a new derivatization pattern for amino acid enantiomers},
  series = {Journal of chromatography A},
  journal   = {Journal of chromatography A},
  number    = {481},
  isbn      = {0021-9673},
  pages     = {380 -- 386},
  year      = {1989},
  language  = {en}
}
@article{KruegerGroetzingerBerndt1987,
  author    = {Kr{\"u}ger, G{\"o}tz and Gr{\"o}tzinger, Joachim and Berndt, Heinz},
  title     = {Enantiomeric resolution of amino acid derivatives on chiral stationary phases by high-performance liquid chromatography},
  series = {Journal of Chromatography A},
  volume    = {1987},
  journal   = {Journal of Chromatography A},
  number    = {397},
  issn      = {0021-9673},
  doi       = {10.1016/S0021-9673(01)85005-6},
  pages     = {223 -- 232},
  year      = {1987},
  language  = {en}
}
@article{KraemerBongaertsBovenbergetal.2003,
  author    = {Kr{\"a}mer, Marco and Bongaerts, Johannes and Bovenberg, Roel and Kremer, Susanne and M{\"u}ller, Ulrike and Orf, Sonja and Wubbolts, Marcel and Raeven, Leon},
  title     = {Metabolic engineering for microbial production of shikimic acid},
  series = {Metabolic engineering},
  volume    = {Vol. 5},
  journal   = {Metabolic engineering},
  number    = {Iss. 4},
  issn      = {1096-7184 (E-Journal); 1096-7176 (Print)},
  pages     = {277 -- 283},
  year      = {2003},
  language  = {en}
}
@article{KotterRiekertWeyland1985,
  author    = {Kotter, Michael and Riekert, Lothar and Weyland, Friedrich},
  title     = {The performance of base metal oxides on ceramic carriers as catalysts for air pollution control},
  series = {International chemical engineering. 25 (1985), H. 3},
  journal   = {International chemical engineering. 25 (1985), H. 3},
  isbn      = {0020-6318},
  pages     = {418 -- 427},
  year      = {1985},
  language  = {en}
}
@article{KotterRiekertWeyland1983,
  author    = {Kotter, Michael and Riekert, L. and Weyland, F.},
  title     = {Deposition of ternary oxides as active components by impregnation of porous carriers},
  series = {Preparation of Catalysts III : scientific bases for the preparation of heterogeneous catalysts ; proceedings of the Third International Symposium, Louvain-la-Neuve, September 6-9, 1982 / ed.: G. Poncelet ... - (Studies in surface science and catalysis ; 16)},
  journal   = {Preparation of Catalysts III : scientific bases for the preparation of heterogeneous catalysts ; proceedings of the Third International Symposium, Louvain-la-Neuve, September 6-9, 1982 / ed.: G. Poncelet ... - (Studies in surface science and catalysis ; 16)},
  publisher = {Elsevier},
  address   = {Amsterdam [u.a.]},
  isbn      = {0-444-42184-X},
  pages     = {521 -- 530},
  year      = {1983},
  language  = {en}
}
@article{KotterRiekert1983,
  author    = {Kotter, Michael and Riekert, L.},
  title     = {Impregnation-type catalysts with nonuniform distribution of the active component},
  series = {Chemical engineering fundamentals. 2 (1983)},
  journal   = {Chemical engineering fundamentals. 2 (1983)},
  isbn      = {0723-0966},
  pages     = {19 -- 38},
  year      = {1983},
  language  = {en}
}
@article{KotterRiekert1979,
  author    = {Kotter, Michael and Riekert, L.},
  title     = {The influence of impregnation, drying and activation on the activity and distribution of CuO on \&\#945;-Alumina},
  series = {Preparation of Catalysts II : scientific bases for the preparation of heterogeneous catalysts ; Proceedings of the Second International Symposium, Louvain-la-Neuve, September 4-7, 1978 / Eds.: B. Delmon ... - (Studies in surface science and catalysis ; 3)},
  journal   = {Preparation of Catalysts II : scientific bases for the preparation of heterogeneous catalysts ; Proceedings of the Second International Symposium, Louvain-la-Neuve, September 4-7, 1978 / Eds.: B. Delmon ... - (Studies in surface science and catalysis ; 3)},
  publisher = {Elsevier},
  address   = {Amsterdam [u.a.]},
  isbn      = {0-444-41733-8},
  pages     = {51 -- 63},
  year      = {1979},
  language  = {en}
}
@article{KotterLintzTurek1992,
  author    = {Kotter, Michael and Lintz, Hans-G{\"u}nther and Turek, Thomas},
  title     = {Selective catalytic reduction of nitrogen oxide by use of the Ljungstroem air heater as reactor : a case study},
  series = {Chemical engineering science . 47 (1992), H. 9-11},
  journal   = {Chemical engineering science . 47 (1992), H. 9-11},
  isbn      = {0009-2509},
  pages     = {2763 -- 2768},
  year      = {1992},
  language  = {en}
}
@article{KotterLintzRiekertetal.1989,
  author    = {Kotter, Michael and Lintz, Hans-G{\"u}nther and Riekert, Lothar and Trimm, D. L.},
  title     = {Structure and selectivity changes in vanadia-titania catalysts used to promote the reduction of nitric oxide with ammonia},
  series = {Applied catalysis. 52 (1989), H. 1},
  journal   = {Applied catalysis. 52 (1989), H. 1},
  isbn      = {0166-9834},
  pages     = {225 -- 235},
  year      = {1989},
  language  = {en}
}
@article{KotterLiRiekert1990,
  author    = {Kotter, Michael and Li, D. X. and Riekert, Lothar},
  title     = {Partial oxidation of o-xylene to phthalic anhydride in a structured fixed bed containing a sequence of catalysts},
  series = {New developments in selective oxidation : proceedings of an international symposium ; Rimini, Italy, Sept. 18 - 22, 1989 / eds.: G. Centi ... - (Studies in surface science and catalysis ; 55)},
  journal   = {New developments in selective oxidation : proceedings of an international symposium ; Rimini, Italy, Sept. 18 - 22, 1989 / eds.: G. Centi ... - (Studies in surface science and catalysis ; 55)},
  publisher = {Elsevier},
  address   = {Amsterdam},
  isbn      = {0-444-88694-X},
  pages     = {267 -- 274},
  year      = {1990},
  language  = {en}
}
@article{KotterHeeringRiekert1982,
  author    = {Kotter, Michael and Heering, J. and Riekert, L.},
  title     = {Diffusion and catalytic reaction in zeolite ZSM-5 / J. Heering ; M. Kotter ; L. Riekert},
  series = {Chemical engineering science . 37 (1982), H. 4},
  journal   = {Chemical engineering science . 37 (1982), H. 4},
  isbn      = {0009-2509},
  pages     = {581 -- 584},
  year      = {1982},
  language  = {en}
}
@article{KotterHammonRiekert1988,
  author    = {Kotter, Michael and Hammon, Ulrich and Riekert, Lothar},
  title     = {Formation of ethene and propene from methanol on zeolite ZSM-5 II. Preparation of finished catalysts and operation of a fixed-bed pilot plant / U. Hammon ; M. Kotter ; L. Riekert},
  series = {Applied catalysis. 37 (1988)},
  journal   = {Applied catalysis. 37 (1988)},
  isbn      = {0166-9834},
  pages     = {155 -- 174},
  year      = {1988},
  language  = {en}
}
@article{KotterHammon1986,
  author    = {Kotter, Michael and Hammon, U.},
  title     = {Preparation of pellets with well-defined pore structure / U. Hammon ; A. Kotter},
  series = {International chemical engineering. 26 (1986), H. 4},
  journal   = {International chemical engineering. 26 (1986), H. 4},
  isbn      = {0020-6318},
  pages     = {563 -- 573},
  year      = {1986},
  language  = {en}
}
@article{KotterGregerIhme1984,
  author    = {Kotter, Michael and Greger, M. and Ihme, B.},
  title     = {Nonequilibrium phase transitions with hysteresis in solid catalysts : the system copper-oxygen-propene / M. Greger ; B. Ihme ; M. Kotter ...},
  series = {Berichte der Bunsen-Gesellschaft f{\"u}r Physikalische Chemie. 88 (1984)},
  journal   = {Berichte der Bunsen-Gesellschaft f{\"u}r Physikalische Chemie. 88 (1984)},
  isbn      = {0005-9021},
  pages     = {427 -- 433},
  year      = {1984},
  language  = {en}
}
@article{KotnikPopovaTodirasetal.2009,
  author    = {Kotnik, Katarina and Popova, Elena and Todiras, Mihail and Mori, Marcelo A. and Alenina, Natalia and Seibler, Jost and Bader, Michael},
  title     = {Inducible transgenic rat model for diabetes mellitus based on shRNA-mediated gene knockdown},
  series = {Plos One},
  volume    = {4},
  journal   = {Plos One},
  number    = {4},
  publisher = {Plos},
  address   = {San Francisco, California, US},
  doi       = {10.1371/journal.pone.0005124},
  pages     = {e5124},
  year      = {2009},
  language  = {en}
}
@article{KornfeldBaitzelKoenneretal.2013,
  author    = {Kornfeld, Jan-Wilhelm and Baitzel, Catherina and K{\"o}nner, A. Christine and Nicholls, Hayley T. and Vogt, Merly C. and Herrmanns, Karolin and Scheja, Ludger and Haumaitre, C{\´e}cile and Wolf, Anna M. and Knippschild, Uwe and Seibler, Jost and Cereghini, Silvia and Heeren, Joerg and Stoffel, Markus and Br{\"u}ning, Jens C.},
  title     = {Obesity-induced overexpression of miR-802 impairs glucose metabolism through silencing of Hnf1b},
  series = {Nature},
  volume    = {494},
  journal   = {Nature},
  number    = {7435},
  publisher = {Springer Nature},
  address   = {Cham},
  isbn      = {0028-0836},
  doi       = {10.1038/nature11793},
  pages     = {111 -- 115},
  year      = {2013},
  language  = {en}
}
@article{KochWunderlichSeibleretal.2008,
  author    = {Koch, Linda and Wunderlich, F. Thomas and Seibler, Jost and K{\"o}nner, A. Christine and Hampel, Brigitte and Irlenbusch, Sigrid and Brabant, Georg and Kahn, C. Ronald and Schwenk, Frieder and Br{\"u}ning, Jens C.},
  title     = {Central insulin action regulates peripheral glucose and fat metabolism in mice},
  series = {The Journal of Clinical Investigation (JCI)},
  volume    = {118},
  journal   = {The Journal of Clinical Investigation (JCI)},
  number    = {6},
  issn      = {1558-8238},
  doi       = {10.1172/JCI31073},
  pages     = {2132 -- 2147},
  year      = {2008},
  language  = {en}
}
@article{KapplerTanudyayaSchmittTippkoetteretal.2007,
  author    = {Kappler-Tanudyaya, Nathalie and Schmitt, Heike and Tippk{\"o}tter, Nils and Meyer, Lina and Lenzen, Sigurd and Ulber, Roland},
  title     = {Combination of biotransformation and chromatography for the isolation and purification of mannoheptulose},
  series = {Biotechnology Journal},
  volume    = {2},
  journal   = {Biotechnology Journal},
  number    = {6},
  issn      = {1860-7314},
  doi       = {10.1002/biot.200700004},
  pages     = {692 -- 699},
  year      = {2007},
  abstract  = {Mannoheptulose is a seven-carbon sugar. It is an inhibitor of glucose-induced insulin secretion due to its ability to selectively inhibit the enzyme glucokinase. An improved procedure for mannoheptulose isolation from avocados is described in this study (based upon the original method by La Forge). The study focuses on the combination of biotransformation and downstream processing (preparative chromatography) as an efficient method to produce a pure extract of mannoheptulose. The experiments were divided into two major phases. In the first phase, several methods and parameters were compared to optimize the mannoheptulose extraction with respect to efficiency and purity. In the second phase, a mass balance of mannoheptulose over the whole extraction process was undertaken to estimate the yield and efficiency of the total extraction process. The combination of biotransformation and preparative chromatography allowed the production of a pure mannoheptulose extract. In a biological test, the sugar inhibited the glucokinase enzyme activity efficiently.},
  language  = {en}
}
@article{KapelyukhHendersonScheeretal.2019,
  author    = {Kapelyukh, Yury and Henderson, Colin James and Scheer, Nico and Rode, Anja and Wolf, Charles Roland},
  title     = {Defining the contribution of CYP1A1 and CYP1A2 to drug metabolism using humanized CYP1A1/1A2 and Cyp1a1/Cyp1a2 KO mice},
  series = {Drug Metabolism and Disposition},
  journal   = {Drug Metabolism and Disposition},
  number    = {Early view},
  doi       = {10.1124/dmd.119.087718},
  pages     = {43 Seiten},
  year      = {2019},
  language  = {en}
}
@article{KalbeKuropkaMeyerStorketal.1988,
  author    = {Kalbe, Jochen and Kuropka, Rolf and Meyer-Stork, L. Sebastian and Berndt, Heinz and Sauter, Sybille L. and Loss, Peter and Hendo, Karsten and Riesner, Detlev and H{\"o}cker, Hartwig},
  title     = {Isolation and characterization of high-molecular mass DNA from hair shafts},
  series = {Biological chemistry},
  volume    = {369},
  journal   = {Biological chemistry},
  number    = {1},
  isbn      = {0177-3593},
  doi       = {10.1515/bchm3.1988.369.1.413},
  pages     = {413 -- 416},
  year      = {1988},
  language  = {en}
}
@article{KalbeHoeckerBerndt1989,
  author    = {Kalbe, Jochen and H{\"o}cker, Hartwig and Berndt, Heinz},
  title     = {Design of enzyme reactors as chromatographic columns for racemic resolution of amino acid esters},
  series = {Chromatographia},
  volume    = {28},
  journal   = {Chromatographia},
  number    = {3-4},
  isbn      = {0009-5893},
  doi       = {10.1007/BF02319646},
  pages     = {193 -- 196},
  year      = {1989},
  language  = {en}
}
@article{JossekBongaertsSprenger2001,
  author    = {Jossek, Ralf and Bongaerts, Johannes and Sprenger, Georg A.},
  title     = {Characterization of a new feedback-resistant 3-deoxy-D-arabinoheptulosonate 7-phosphate synthase AroF of Escherichia coli},
  series = {FEMS microbiology letters},
  volume    = {Vol. 202},
  journal   = {FEMS microbiology letters},
  number    = {Iss. 1},
  issn      = {1574-6968},
  pages     = {145 -- 148},
  year      = {2001},
  language  = {en}
}
@article{JordanKruegerWillmesetal.2011,
  author    = {Jordan, Sabine D. and Kr{\"u}ger, Markus and Willmes, Diana M. and Redemann, Nora and Wunderlich, F. Thomas and Br{\"o}nneke, Hella S. and Merkwirth, Carsten and Kashkar, Hamid and Olkkonen, Vesa M. and B{\"o}ttger, Thomas and Braun, Thomas and Seibler, Jost and Br{\"u}ning, Jens C.},
  title     = {Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism},
  series = {Nature Cell Biology},
  volume    = {13},
  journal   = {Nature Cell Biology},
  number    = {4},
  publisher = {Nature},
  address   = {New York},
  issn      = {1465-7392},
  doi       = {10.1038/ncb2211},
  pages     = {434 -- 446},
  year      = {2011},
  abstract  = {The contribution of altered post-transcriptional gene silencing to the development of insulin resistance and type 2 diabetes mellitus so far remains elusive. Here, we demonstrate that expression of microRNA (miR)-143 and 145 is upregulated in the liver of genetic and dietary mouse models of obesity. Induced transgenic overexpression of miR-143, but not miR-145, impairs insulin-stimulated AKT activation and glucose homeostasis. Conversely, mice deficient for the miR-143-145 cluster are protected from the development of obesity-associated insulin resistance. Quantitative-mass-spectrometry-based analysis of hepatic protein expression in miR-143-overexpressing mice revealed miR-143-dependent downregulation of oxysterol-binding-protein-related protein (ORP) 8. Reduced ORP8 expression in cultured liver cells impairs the ability of insulin to induce AKT activation, revealing an ORP8-dependent mechanism of AKT regulation. Our experiments provide direct evidence that dysregulated post-transcriptional gene silencing contributes to the development of obesity-induced insulin resistance, and characterize the miR-143-ORP8 pathway as a potential target for the treatment of obesity-associated diabetes.},
  language  = {en}
}
@article{JerominZoor2008,
  author    = {Jeromin, G{\"u}nter Erich and Zoor, Annegreth},
  title     = {A new irreversible enzyme-aided esterification method in organic solvents},
  series = {Biotechnology letters. 30 (2008), H. 5},
  journal   = {Biotechnology letters. 30 (2008), H. 5},
  isbn      = {1573-6776},
  pages     = {925 -- 928},
  year      = {2008},
  language  = {en}
}
@article{JerominWelsch1995,
  author    = {Jeromin, G{\"u}nter Erich and Welsch, Volker},
  title     = {Diketene a New Esterification Reagent in the Enzyme-Aided Synthesis of Chiral Alcohols and Chiral Acetoacetic Acid Esters},
  series = {Tetrahedron Letters . 36 (1995), H. 37},
  journal   = {Tetrahedron Letters . 36 (1995), H. 37},
  isbn      = {0040-4039},
  pages     = {6663 -- 6664},
  year      = {1995},
  language  = {en}
}
@article{JerominScheidt1991,
  author    = {Jeromin, G{\"u}nter Erich and Scheidt, Annette},
  title     = {Aliphatic optically active alcohols by enzyme-aided synthesis},
  series = {Tetrahedron Letters . 32 (1991), H. 48},
  journal   = {Tetrahedron Letters . 32 (1991), H. 48},
  isbn      = {0040-4039},
  pages     = {7021 -- 7024},
  year      = {1991},
  language  = {en}
}
@article{JerominAlbertz1992,
  author    = {Jeromin, G{\"u}nter Erich and Albertz, Michael},
  title     = {Optically active \&\#945;-acetoxycarboxylic acids and \&\#945;-hydroxycarboxylic acids by enzyme-aided syntheses},
  series = {Journal f{\"u}r Praktische Chemie / Chemiker-Zeitung. 334 (1992), H. 6},
  journal   = {Journal f{\"u}r Praktische Chemie / Chemiker-Zeitung. 334 (1992), H. 6},
  isbn      = {1436-9966},
  pages     = {526 -- 528},
  year      = {1992},
  language  = {en}
}
@article{Jeromin2009,
  author    = {Jeromin, G{\"u}nter Erich},
  title     = {Superabsorbed alcohol dehydrogenase—a new catalyst for asymmetric reductions},
  series = {Biotechnology Letters. 31 (2009), H. 11},
  journal   = {Biotechnology Letters. 31 (2009), H. 11},
  isbn      = {0141-5492},
  pages     = {1717 -- 1721},
  year      = {2009},
  language  = {en}
}
@article{Jeromin2001,
  author    = {Jeromin, G{\"u}nter Erich},
  title     = {Tetrabenzo[a,c,h,j]phenoxazine-18-yl a new stable neutral radical},
  series = {Tetrahedron Letters . 42 (2001), H. 10},
  journal   = {Tetrahedron Letters . 42 (2001), H. 10},
  isbn      = {0040-4039},
  pages     = {1863 -- 1865},
  year      = {2001},
  language  = {en}
}
@article{JakobMartinezMandaweetal.2013,
  author    = {Jakob, Felix and Martinez, Ronny and Mandawe, John and Hellmuth, Hendrik and Siegert, Petra and Maurer, Karl-Heinz and Schwaneberg, Ulrich},
  title     = {Surface charge engineering of a Bacillus gibsonii subtilisin protease},
  series = {Applied microbiology and biotechnology},
  volume    = {Vol. 97},
  journal   = {Applied microbiology and biotechnology},
  number    = {Iss. 15},
  publisher = {Springer},
  address   = {Berlin},
  issn      = {1432-0614 (E-Journal); 0171-1741 (Print); 0175-7598 (Print); 0340-2118 (Print)},
  pages     = {6793 -- 6802},
  year      = {2013},
  language  = {en}
}
@article{JahnkeBaumann1987,
  author    = {Jahnke, J. and Baumann, Marcus},
  title     = {Differentiation between Phaeocystis pouchetii (Har.) Lagerheim and Phaeocystis globosa Scherffel},
  series = {Hydrobiological bulletin},
  volume    = {Vol. 21},
  journal   = {Hydrobiological bulletin},
  number    = {Iss. 2},
  issn      = {0165-1404 (Print); 1573-5125 (E-Journal)},
  pages     = {141 -- 147},
  year      = {1987},
  language  = {en}
}
@article{JablonskiMuenstermannNorketal.2021,
  author    = {Jablonski, Melanie and M{\"u}nstermann, Felix and Nork, Jasmina and Molinnus, Denise and Muschallik, Lukas and Bongaerts, Johannes and Wagner, Torsten and Keusgen, Michael and Siegert, Petra and Sch{\"o}ning, Michael Josef},
  title     = {Capacitive field-effect biosensor applied for the detection of acetoin in alcoholic beverages and fermentation broths},
  series = {physica status solidi (a) applications and materials science},
  volume    = {218},
  journal   = {physica status solidi (a) applications and materials science},
  number    = {13},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {1862-6319},
  doi       = {10.1002/pssa.202000765},
  pages     = {7 Seiten},
  year      = {2021},
  abstract  = {An acetoin biosensor based on a capacitive electrolyte-insulator-semiconductor (EIS) structure modified with the enzyme acetoin reductase, also known as butane-2,3-diol dehydrogenase (Bacillus clausii DSM 8716ᵀ), is applied for acetoin detection in beer, red wine, and fermentation broth samples for the first time. The EIS sensor consists of an Al/p-Si/SiO₂/Ta₂O₅ layer structure with immobilized acetoin reductase on top of the Ta₂O₅ transducer layer by means of crosslinking via glutaraldehyde. The unmodified and enzyme-modified sensors are electrochemically characterized by means of leakage current, capacitance-voltage, and constant capacitance methods, respectively.},
  language  = {en}
}
@article{InfantinoPaulssenMostaccietal.2016,
  author    = {Infantino, Angelo and Paulßen, Elisabeth and Mostacci, Domiziano and Schaffer, Paul and Trinczek, Michael and Hoehr, Cornelia},
  title     = {Assessment of the production of medical isotopes using the Monte Carlo code FLUKA: Simulations against experimental measurements},
  series = {Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms},
  volume    = {366},
  journal   = {Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1872-9584},
  doi       = {10.1016/j.nimb.2015.10.067},
  pages     = {117 -- 123},
  year      = {2016},
  abstract  = {The Monte Carlo code FLUKA is used to simulate the production of a number of positron emitting radionuclides, ¹⁸F, ¹³N, ⁹⁴Tc, ⁴⁴Sc, ⁶⁸Ga, ⁸⁶Y, ⁸⁹Zr, ⁵²Mn, ⁶¹Cu and ⁵⁵Co, on a small medical cyclotron with a proton beam energy of 13 MeV. Experimental data collected at the TR13 cyclotron at TRIUMF agree within a factor of 0.6 ± 0.4 with the directly simulated data, except for the production of ⁵⁵Co, where the simulation underestimates the experiment by a factor of 3.4 ± 0.4. The experimental data also agree within a factor of 0.8 ± 0.6 with the convolution of simulated proton fluence and cross sections from literature. Overall, this confirms the applicability of FLUKA to simulate radionuclide production at 13 MeV proton beam energy.},
  language  = {en}
}
@article{InagakiSleddensLinkelsWassenaaretal.2011,
  author    = {Inagaki, Akiko and Sleddens-Linkels, Esther and Wassenaar, Evelyne and Ooms, Marja and Cappellen, Wiggert A. van and Hoeijmakers, Jan H. J. and Seibler, Jost and Vogt, Thomas F. and Shin, Myung K. and Grootegoed, J. Anton and Baarends, Willy M.},
  title     = {Meiotic functions of RAD18},
  series = {Journal of Cell Science},
  volume    = {124},
  journal   = {Journal of Cell Science},
  number    = {16},
  publisher = {Company of Biologists Limited},
  address   = {Cambridge},
  issn      = {1477-9137},
  doi       = {10.1242/jcs.081968},
  pages     = {2837 -- 2850},
  year      = {2011},
  language  = {en}
}
@article{ImmelGruetzkeSpaeteetal.2012,
  author    = {Immel, Timo and Gr{\"u}tzke, Martin and Sp{\"a}te, Anne-Katrin and Groth, Ulrich and {\"O}hlschl{\"a}ger, Peter and Huhn, Thomas},
  title     = {Synthesis and X-ray structure analysis of a heptacoordinate titanium(IV)-bis-chelate with enhanced in vivo antitumor efficacy},
  series = {Chemical Communications},
  volume    = {48},
  journal   = {Chemical Communications},
  number    = {46},
  publisher = {Royal Society of Chemistry},
  address   = {Cambridge},
  issn      = {1364-548X},
  doi       = {10.1039/C2CC31624B},
  pages     = {5790 -- 5792},
  year      = {2012},
  abstract  = {Chelate stabilization of a titanium(IV)-salan alkoxide by ligand exchange with 2,6-pyridinedicarboxylic acid (dipic) resulted in heptacoordinate complex 3 which is not redox-active, stable on silica gel and has increased aqueous stability. 3 is highly toxic in HeLa S3 and Hep G2 and has enhanced antitumor efficacy in a mouse cervical-cancer model.},
  language  = {en}
}
@article{ImmelGrothHuhnetal.2011,
  author    = {Immel, Timo A. and Groth, Ulrich and Huhn, Thomas and {\"O}hlschl{\"a}ger, Peter},
  title     = {Titanium salan complexes displays strong antitumor properties in vitro and in vivo in mice},
  series = {PLoS ONE},
  volume    = {6},
  journal   = {PLoS ONE},
  number    = {3},
  publisher = {Plos},
  address   = {San Francisco, California, US},
  doi       = {10.1371/journal.pone.0017869},
  pages     = {e17869},
  year      = {2011},
  abstract  = {The anticancer activity of titanium complexes has been known since the groundbreaking studies of K{\"o}pf and K{\"o}pf-Maier on titanocen dichloride. Unfortunately, possibly due to their fast hydrolysis, derivatives of titanocen dichloride failed in clinical studies. Recently, the new family of titanium salan complexes containing tetradentate ONNO ligands with anti-cancer properties has been discovered. These salan complexes are much more stabile in aqueous media. In this study we describe the biological activity of two titanium salan complexes in a mouse model of cervical cancer. High efficiency of this promising complex family was demonstrated for the first time in vivo. From these data we conclude that titanium salan complexes display very strong antitumor properties exhibiting only minor side effects. Our results may influence the chemotherapy with metallo therapeutics in the future.},
  language  = {en}
}
@article{IdingSiegertMeschetal.1998,
  author    = {Iding, Hans and Siegert, Petra and Mesch, K. and Pohl, Martina},
  title     = {Application of α-keto acid decarboxylases in biotransformations},
  series = {Biochimica et biophysica acta (BBA) - Protein structure and molecular enzymology},
  volume    = {Vol. 1385},
  journal   = {Biochimica et biophysica acta (BBA) - Protein structure and molecular enzymology},
  number    = {Iss. 2},
  issn      = {1879-2588 (E-Journal); 0167-4838 (Print)},
  pages     = {307 -- 322},
  year      = {1998},
  language  = {en}
}
@article{IdingDuennwaldGreineretal.2000,
  author    = {Iding, Hans and D{\"u}nnwald, Thomas and Greiner, Lasse and Liese, Andreas and M{\"u}ller, Michael and Siegert, Petra and Gr{\"o}tzinger, Joachim and Demir, Ayhan S. and Pohl, Martina},
  title     = {Benzoylformate Decarboxylase from Pseudomonas putida as Stable Catalyst for the Synthesis of Chiral 2-Hydroxy Ketones},
  series = {Chemistry - a European journal},
  volume    = {Vol. 6},
  journal   = {Chemistry - a European journal},
  number    = {Iss. 8},
  issn      = {1521-3765 (E-Journal); 0947-6539 (Print)},
  pages     = {1483 -- 1495},
  year      = {2000},
  language  = {en}
}
@article{IberSchuebelerSeibleretal.1998,
  author    = {Iber, Michaela and Sch{\"u}beler, Dirk and Seibler, Jost and H{\"o}xter, Maria and Bode, J{\"u}rgen},
  title     = {Efficient FACS selection procedure for cells undergoing Flp-mediated site-specific conversions},
  series = {Technical Tips Online},
  volume    = {4},
  journal   = {Technical Tips Online},
  number    = {1},
  doi       = {10.1016/S1366-2120(08)70132-6},
  pages     = {25 -- 29},
  year      = {1998},
  language  = {en}
}
@article{HuckSchiffelsHerreraetal.2013,
  author    = {Huck, Christina and Schiffels, Johannes and Herrera, Cony N. and Schelden, Maximilian and Selmer, Thorsten and Poghossian, Arshak and Baumann, Marcus and Wagner, Patrick and Sch{\"o}ning, Michael Josef},
  title     = {Metabolic responses of Escherichia coli upon glucose pulses captured by a capacitive field-effect sensor},
  series = {Physica Status Solidi (A)},
  volume    = {210},
  journal   = {Physica Status Solidi (A)},
  number    = {5},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {0031-8965},
  doi       = {10.1002/pssa.201200900},
  pages     = {926 -- 931},
  year      = {2013},
  abstract  = {Living cells are complex biological systems transforming metabolites taken up from the surrounding medium. Monitoring the responses of such cells to certain substrate concentrations is a challenging task and offers possibilities to gain insight into the vitality of a community influenced by the growth environment. Cell-based sensors represent a promising platform for monitoring the metabolic activity and thus, the "welfare" of relevant organisms. In the present study, metabolic responses of the model bacterium Escherichia coli in suspension, layered onto a capacitive field-effect structure, were examined to pulses of glucose in the concentration range between 0.05 and 2 mM. It was found that acidification of the surrounding medium takes place immediately after glucose addition and follows Michaelis-Menten kinetic behavior as a function of the glucose concentration. In future, the presented setup can, therefore, be used to study substrate specificities on the enzymatic level and may as well be used to perform investigations of more complex metabolic responses. Conclusions and perspectives highlighting this system are discussed.},
  language  = {en}
}
@article{HoughNalwalkDingetal.2015,
  author    = {Hough, Lindsay B. and Nalwalk, Julia W. and Ding, Xinxin and Scheer, Nico},
  title     = {Opioid Analgesia in P450 Gene Cluster Knockout Mice: A Search for Analgesia-Relevant Isoforms},
  series = {Drug Metabolism and Disposition},
  volume    = {43},
  journal   = {Drug Metabolism and Disposition},
  number    = {9},
  issn      = {1521-009x},
  doi       = {10.1124/dmd.115.065490},
  pages     = {1326 -- 1330},
  year      = {2015},
  language  = {en}
}
@article{HoffstadtNikolauszKrafftetal.2024,
  author    = {Hoffstadt, Kevin and Nikolausz, Marcell and Krafft, Simone and Bonatelli, Maria and Kumar, Vivekanantha and Harms, Hauke and Kuperjans, Isabel},
  title     = {Optimization of the ex situ biomethanation of hydrogen and carbon dioxide in a novel meandering plug flow reactor: start-up phase and flexible operation},
  series = {Bioengineering},
  volume    = {11},
  journal   = {Bioengineering},
  number    = {2},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2306-5354},
  doi       = {10.3390/bioengineering11020165},
  pages     = {18 Seiten},
  year      = {2024},
  language  = {en}
}
@article{HoffstadtCheenakulaNikolauszetal.2023,
  author    = {Hoffstadt, Kevin and Cheenakula, Dheeraja and Nikolausz, Marcell and Krafft, Simone and Harms, Hauke and Kuperjans, Isabel},
  title     = {Design and construction of a new reactor for flexible biomethanation of hydrogen},
  series = {Fermentation},
  volume    = {9},
  journal   = {Fermentation},
  number    = {8},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2311-5637},
  doi       = {10.3390/fermentation9080774},
  pages     = {1 -- 16},
  year      = {2023},
  abstract  = {The increasing share of renewable electricity in the grid drives the need for sufficient storage capacity. Especially for seasonal storage, power-to-gas can be a promising approach. Biologically produced methane from hydrogen produced from surplus electricity can be used to substitute natural gas in the existing infrastructure. Current reactor types are not or are poorly optimized for flexible methanation. Therefore, this work proposes a new reactor type with a plug flow reactor (PFR) design. Simulations in COMSOL Multiphysics ® showed promising properties for operation in laminar flow. An experiment was conducted to support the simulation results and to determine the gas fraction of the novel reactor, which was measured to be 29\%. Based on these simulations and experimental results, the reactor was constructed as a 14 m long, 50 mm diameter tube with a meandering orientation. Data processing was established, and a step experiment was performed. In addition, a kLa of 1 h-1 was determined. The results revealed that the experimental outcomes of the type of flow and gas fractions are in line with the theoretical simulation. The new design shows promising properties for flexible methanation and will be tested.},
  language  = {en}
}
@article{HoehrPaulssenBenardetal.2014,
  author    = {Hoehr, Cornelia and Paulßen, Elisabeth and Benard, Francois and Lee, Chris Jaeil and Hou, Xinchi and Badesso, Brian and Ferguson, Simon and Miao, Qing and Yang, Hua and Buckley, Ken and Hanemaayer, Victoire and Zeisler, Stefan and Ruth, Thomas and Celler, Anna and Schaffer, Paul},
  title     = {⁴⁴ᶢSc production using a water target on a 13 MeV cyclotron},
  series = {Nuclear medicine and biology},
  volume    = {41},
  journal   = {Nuclear medicine and biology},
  number    = {5},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1872-9614},
  doi       = {10.1016/j.nucmedbio.2013.12.016},
  pages     = {401 -- 406},
  year      = {2014},
  abstract  = {Access to promising radiometals as isotopes for novel molecular imaging agents requires that they are routinely available and inexpensive to obtain. Proximity to a cyclotron center outfitted with solid target hardware, or to an isotope generator for the metal of interest is necessary, both of which can introduce significant hurdles in development of less common isotopes. Herein, we describe the production of ⁴⁴Sc (t₁⸝₂ = 3.97 h, Eavg,β⁺ = 1.47 MeV, branching ratio = 94.27\%) in a solution target and an automated loading system which allows a quick turn-around between different radiometallic isotopes and therefore greatly improves their availability for tracer development. Experimental yields are compared to theoretical calculations.},
  language  = {en}
}
@article{HeroldBrandtSeibleretal.2008,
  author    = {Herold, Marco J. and Brandt, Jens van den and Seibler, Jost and Reichardt, Holger M.},
  title     = {Inducible and reversible gene silencing by stable integration of an shRNA-encoding lentivirus in transgenic rats},
  series = {Proceedings of the National Academy of Sciences of the United States of America},
  volume    = {105},
  journal   = {Proceedings of the National Academy of Sciences of the United States of America},
  number    = {47},
  issn      = {1091-6490},
  doi       = {10.1073/pnas.0806213105},
  pages     = {18507 -- 18512},
  year      = {2008},
  language  = {en}
}
@article{HentschkeHagerHojdis2014,
  author    = {Hentschke, Reinhard and Hager, Jonathan and Hojdis, Nils},
  title     = {Molecular Modeling Approach to the Prediction of Mechanical Properties of Silica-Reinforced Rubbers},
  series = {Journal of Applied Polymer Science},
  volume    = {131},
  journal   = {Journal of Applied Polymer Science},
  number    = {18},
  publisher = {Wiley},
  address   = {New York, NY},
  issn      = {1097-4628},
  doi       = {10.1002/app.40806},
  pages     = {1 -- 9},
  year      = {2014},
  abstract  = {Recently, we have suggested a nanomechanical model for dissipative loss in filled elastomer networks in the context of the Payne effect. The mechanism is based on a total interfiller particle force exhibiting an intermittent loop, due to the combination of short-range repulsion and dispersion forces with a long-range elastic attraction. The sum of these forces leads, under external strain, to a spontaneous instability of "bonds" between the aggregates in a filler network and attendant energy dissipation. Here, we use molecular dynamics simulations to obtain chemically realistic forces between surface modified silica particles. The latter are combined with the above model to estimate the loss modulus and the low strain storage modulus in elastomers containing the aforementioned filler-compatibilizer systems. The model is compared to experimental dynamic moduli of silica filled rubbers. We find good agreement between the model predictions and the experiments as function of the compatibilizer's molecular structure and its bulk concentration.},
  language  = {en}
}
@article{HenkenOosterhuisOehlschlaegeretal.2012,
  author    = {Henken, F. E. and Oosterhuis, K. and {\"O}hlschl{\"a}ger, Peter and Bosch, L. and Hooijberg, E. and Haanen, J. B. A. G. and Steenbergen, R. D. M.},
  title     = {Preclinical safety evaluation of DNA vaccines encoding modified HPV16 E6 and E7},
  series = {Vaccine},
  volume    = {30},
  journal   = {Vaccine},
  number    = {28},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0264-410X},
  doi       = {10.1016/j.vaccine.2012.04.013},
  pages     = {4259 -- 4266},
  year      = {2012},
  abstract  = {Persistent infection with high-risk human papillomaviruses (hrHPV) can result in the formation of anogenital cancers. As hrHPV proteins E6 and E7 are required for cancer initiation and maintenance, they are ideal targets for immunotherapeutic interventions. Previously, we have described the development of DNA vaccines for the induction of HPV16 E6 and E7 specific T cell immunity. These vaccines consist of 'gene-shuffled' (SH) versions of HPV16 E6 and E7 that were fused to Tetanus Toxin Fragment C domain 1 (TTFC) and were named TTFC-E6SH and TTFC-E7SH. Gene-shuffling was performed to avoid the risk of inducing malignant transformation at the vaccination site. Here, we describe the preclinical safety evaluation of these candidate vaccines by analysis of their transforming capacity in vitro using established murine fibroblasts (NIH 3T3 cells) and primary human foreskin keratinocytes (HFKs). We demonstrate that neither ectopic expression of TTFC-E6SH and TTFC-E7SH alone or in combination enabled NIH 3T3 cells to form colonies in soft agar. In contrast, expression of HPV16 E6WT and E7WT alone or in combination resulted in effective transformation. Similarly, retroviral transduction of HFKs from three independent donors with both TTFC-E6SH and TTFC-E7SH alone or in combination did not show any signs of immortalization. In contrast, the combined expression of E6WT and E7WT induced immortalization in HFKs from all donors. Based on these results we consider it justified to proceed to clinical evaluation of DNA vaccines encoding TTFC-E6SH and TTFC-E7SH in patients with HPV16 associated (pre)malignancies.},
  language  = {en}
}
@article{HengsbachEngelCwienczeketal.2023,
  author    = {Hengsbach, Jan-Niklas and Engel, Mareike and Cwienczek, Marcel and Stiefelmaier, Judith and Tippk{\"o}tter, Nils and Ulber, Roland},
  title     = {Scalable unseparated bioelectrochemical reactors by using a carbon fiber brush as stirrer and working electrode},
  series = {ChemElectroChem},
  volume    = {10},
  journal   = {ChemElectroChem},
  number    = {21},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {2196-0216},
  doi       = {10.1002/celc.202300440},
  pages     = {9 Seiten},
  year      = {2023},
  abstract  = {The concept of energy conversion into platform chemicals using bioelectrochemical systems (BES) has gained increasing attention in recent years, as the technology simultaneously provides an opportunity for sustainable chemical production and tackles the challenge of Power-to-X technologies. There are many approaches to realize the industrial scale of BES. One concept is to equip standard bioreactors with static electrodes. However, large installations resulted in a negative influence on various reactor parameters. In this study, we present a new single-chamber BES based on a stirred tank reactor in which the stirrer was replaced by a carbon fiber brush, performing the functions of the working electrode and the stirrer. The reactor is characterized in abiotic studies and electro-fermentations with Clostridium acetobutylicum. Compared to standard reactors an increase in butanol production of 20.14±3.66 \% shows that the new BES can be efficiently used for bioelectrochemical processes.},
  language  = {en}
}