@article{HacklMuellerStaatetal.2016, author = {Hackl, Michael and M{\"u}ller, Lars-Peter and Staat, Manfred and Kahmann, Stephanie Lucina and Wegmann, Kilian}, title = {Proximal phalangeal neck fractures of the hand — a biomechanical comparison of three fixation techniques}, series = {Knee surgery, sports traumatology, arthroscopy}, volume = {Volume 24}, journal = {Knee surgery, sports traumatology, arthroscopy}, number = {Supplement 1}, publisher = {Springer}, address = {Berlin}, issn = {0942-2056}, doi = {10.1007/s00167-016-4080-7}, pages = {148 -- 149}, year = {2016}, abstract = {Plate osteosynthesis of displaced proximal phalangeal neck fractures of the hand allows early mobilization due to a stable internal fixation. Nevertheless, joint stiffness—because of soft tissue irritation—represents a common complication leading to high complication rates. Del Pinal et al. recently reported promising clinical results for a new, minimally invasive fixation technique with a cannulated headless intramedullary compression screw. Hence, the aim of this study was to compare plate fixation of proximal phalangeal neck fractures to less two less invasive techniques: Crossed k-wire fixation and intramedullary screw fixation. We hypothesized that these fixation techniques provide inferior stability when compared to plate osteosynthesis.}, language = {en} } @article{BuniatyanHuckPoghossianetal.2013, author = {Buniatyan, V. and Huck, Christina and Poghossian, Arshak and Aroutiounian, V. M. and Sch{\"o}ning, Michael Josef}, title = {BaxSr1-x TiO3/pc-Si heterojunction}, series = {Armenian journal of physics}, volume = {6}, journal = {Armenian journal of physics}, number = {4}, publisher = {National Academy of Sciences of Armenia}, address = {Yerevan}, issn = {1829-1171}, pages = {177 -- 187}, year = {2013}, language = {en} } @article{YoshinobuEckenPoghossianetal.2001, author = {Yoshinobu, T. and Ecken, H. and Poghossian, Arshak and L{\"u}th, H. and Iwasaki, H. and Sch{\"o}ning, Michael Josef}, title = {Alternative sensor materials for light-addressable potentiometric sensors}, series = {Sensors and Actuators B. 76 (2001), H. 1-3}, journal = {Sensors and Actuators B. 76 (2001), H. 1-3}, isbn = {0925-4005}, pages = {388 -- 392}, year = {2001}, language = {en} } @article{PoghossianAbouzarSakkarietal.2006, author = {Poghossian, Arshak and Abouzar, Maryam H. and Sakkari, M. and Kassab, T. and Han, Y. and Ingebrandt, S. and Offenh{\"a}usser, A. and Sch{\"o}ning, Michael Josef}, title = {Field-effect sensors for monitoring the layer-by-layer adsorption of charged macromolecules}, series = {Sensors and Actuators B: Chemical. 118 (2006), H. 1-2}, journal = {Sensors and Actuators B: Chemical. 118 (2006), H. 1-2}, isbn = {0925-4005}, pages = {163 -- 170}, year = {2006}, language = {en} } @article{LinderBecklerDoerretal.2019, author = {Linder, Peter and Beckler, Matthias and Doerr, Leo and Stoelzle-Feix, Sonja and Fertig, Niels and Jung, Alexander and Staat, Manfred and Gossmann, Matthias}, title = {A new in vitro tool to investigate cardiac contractility under physiological mechanical conditions}, series = {Journal of Pharmacological and Toxicological Methods}, volume = {99}, journal = {Journal of Pharmacological and Toxicological Methods}, number = {Article number 106595}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1056-8719}, doi = {10.1016/j.vascn.2019.05.162}, year = {2019}, language = {en} } @article{LinderDigelTemizArtmannetal.2007, author = {Linder, Peter and Digel, Ilya and Temiz Artmann, Ayseg{\"u}l and Kayser, Peter and Porst, Dariusz and Artmann, Gerhard}, title = {High-throughput testing of mechanical forces generated in thin cell and tissue layers}, series = {Tissue Engineering. 13 (2007), H. 7}, journal = {Tissue Engineering. 13 (2007), H. 7}, isbn = {1076-3279}, pages = {1778 -- 1778}, year = {2007}, language = {en} } @book{Laack2000, author = {Laack, Walter van}, title = {Pl{\"a}doyer f{\"u}r ein Leben nach dem Tod und eine etwas andere Sicht der Welt}, edition = {2., komplett {\"u}berarb. Aufl.}, publisher = {van Laack}, address = {Aachen}, isbn = {978-3-89811-818-7}, pages = {447 S. : graph. Darst.}, year = {2000}, language = {de} } @article{KraemerPitaZhouetal.2009, author = {Kr{\"a}mer, Melina and Pita, Marcos and Zhou, Jian and Ornatska, Maryna and Poghossian, Arshak and Sch{\"o}ning, Michael Josef and Katz, Evgeny}, title = {Coupling of Biocomputing Systems with Electronic Chips: Electronic Interface for Transduction of Biochemical Information}, series = {Journal of Physical Chemistry C: Nanomaterials and Interfaces. 113 (2009), H. 6}, journal = {Journal of Physical Chemistry C: Nanomaterials and Interfaces. 113 (2009), H. 6}, publisher = {American Cemical Society}, address = {Washington, DC}, isbn = {1932-7455}, pages = {2573 -- 2579}, year = {2009}, language = {en} } @article{HuckJollyWagneretal.2011, author = {Huck, Christina and Jolly, Christina and Wagner, Patrick and Poghossian, Arshak and Sch{\"o}ning, Michael Josef}, title = {One-chip integrated dual amperometric/field-effect sensor for the detection of dissolved hydrogen}, series = {Procedia Engineering. 25 (2011)}, journal = {Procedia Engineering. 25 (2011)}, publisher = {Elsevier}, address = {Amsterdam}, isbn = {1877-7058}, pages = {1161 -- 1164}, year = {2011}, language = {en} } @article{WuBronderPoghossianetal.2014, author = {Wu, Chunsheng and Bronder, Thomas and Poghossian, Arshak and Werner, Frederik and B{\"a}cker, Matthias and Sch{\"o}ning, Michael Josef}, title = {Label-free electrical detection of DNA with a multi-spot LAPS: First step towards light-addressable DNA chips}, series = {Physica status solidi A : Applications and materials science}, volume = {211}, journal = {Physica status solidi A : Applications and materials science}, number = {6}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1521-396X (E-Journal); 1862-6319 (E-Journal); 0031-8965 (Print); 1862-6300 (Print)}, doi = {10.1002/pssa.201330442}, pages = {1423 -- 1428}, year = {2014}, abstract = {A multi-spot (4 × 4 spots) light-addressable potentiometric sensor (MLAPS) consisting of an Al-p-Si-SiO2 structure has been applied for the label-free electrical detection of DNA (deoxyribonucleic acid) immobilization and hybridization by the intrinsic molecular charge for the first time. Single-stranded probe ssDNA molecules (20 bases) were covalently immobilized onto the silanized SiO2 gate surface. The unspecific adsorption of mismatch ssDNA on the MLAPS gate surface was blocked by bovine serum albumin molecules. To reduce the screening effect and to achieve a high sensor signal, the measurements were performed in a low ionic-strength solution. The photocurrent-voltage (I-V) curves were simultaneously recorded on all 16 spots after each surface functionalization step. Large shifts of I-V curves of 25 mV were registered after the DNA immobilization and hybridization event. In contrast, a small potential shift (∼5 mV) was observed in case of mismatch ssDNA, revealing good specificity of the sensor. The obtained results demonstrate the potential of the MLAPS as promising transducer platform for the multi-spot label-free electrical detection of DNA molecules by their intrinsic molecular charge.}, language = {en} } @inproceedings{NaetherPoghossianPlatenetal.2006, author = {N{\"a}ther, Niko and Poghossian, Arshak and Platen, J. and Yoshinobu, T. and Koudelka-Hep, M. and Sch{\"o}ning, Michael Josef}, title = {Multi-parameter sensing of both physical and (bio-)chemical quantities using the same transducer principle}, series = {Biochemical sensing utilisation of micro- and nanotechnologies : Warsaw, [23rd - 26th] November 2005 / ed. by M. Mascini ...}, booktitle = {Biochemical sensing utilisation of micro- and nanotechnologies : Warsaw, [23rd - 26th] November 2005 / ed. by M. Mascini ...}, address = {Warsaw}, pages = {172 -- 181}, year = {2006}, language = {en} } @article{StaatHeitzer2000, author = {Staat, Manfred and Heitzer, M.}, title = {Traglastanalyse - ein strukturmechanisches Verfahren zur Beurteilung von gerissenen Bauteilen und Verbindungen}, series = {Festigkeits- und Bruchverhalten von F{\"u}geverbindungen : 32. Tagung des DVM-Arbeitskreises Bruchvorg{\"a}nge ; 22. und 23. Februar 2000 in Berlin / Richard, H. A. [Hrsg]}, journal = {Festigkeits- und Bruchverhalten von F{\"u}geverbindungen : 32. Tagung des DVM-Arbeitskreises Bruchvorg{\"a}nge ; 22. und 23. Februar 2000 in Berlin / Richard, H. A. [Hrsg]}, publisher = {Deutscher Verband f{\"u}r Materialforschung und -pr{\"u}fung}, address = {Berlin}, pages = {183 -- 192}, year = {2000}, language = {de} } @article{LaackCasser1989, author = {Laack, Walter van and Casser, H.-R.}, title = {Arthroskopische Behandlung der Osteochondrosis dissecans an der medialen Femurrolle}, series = {Arthroskopie. 2 (1989), H. 1}, journal = {Arthroskopie. 2 (1989), H. 1}, isbn = {0933-7946}, pages = {16 -- 18}, year = {1989}, language = {de} } @article{PoghossianJablonskiMolinnusetal.2020, author = {Poghossian, Arshak and Jablonski, Melanie and Molinnus, Denise and Wege, Christina and Sch{\"o}ning, Michael Josef}, title = {Field-Effect Sensors for Virus Detection: From Ebola to SARS-CoV-2 and Plant Viral Enhancers}, series = {Frontiers in Plant Science}, volume = {11}, journal = {Frontiers in Plant Science}, number = {Article 598103}, publisher = {Frontiers}, address = {Lausanne}, doi = {10.3389/fpls.2020.598103}, pages = {1 -- 14}, year = {2020}, abstract = {Coronavirus disease 2019 (COVID-19) is a novel human infectious disease provoked by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Currently, no specific vaccines or drugs against COVID-19 are available. Therefore, early diagnosis and treatment are essential in order to slow the virus spread and to contain the disease outbreak. Hence, new diagnostic tests and devices for virus detection in clinical samples that are faster, more accurate and reliable, easier and cost-efficient than existing ones are needed. Due to the small sizes, fast response time, label-free operation without the need for expensive and time-consuming labeling steps, the possibility of real-time and multiplexed measurements, robustness and portability (point-of-care and on-site testing), biosensors based on semiconductor field-effect devices (FEDs) are one of the most attractive platforms for an electrical detection of charged biomolecules and bioparticles by their intrinsic charge. In this review, recent advances and key developments in the field of label-free detection of viruses (including plant viruses) with various types of FEDs are presented. In recent years, however, certain plant viruses have also attracted additional interest for biosensor layouts: Their repetitive protein subunits arranged at nanometric spacing can be employed for coupling functional molecules. If used as adapters on sensor chip surfaces, they allow an efficient immobilization of analyte-specific recognition and detector elements such as antibodies and enzymes at highest surface densities. The display on plant viral bionanoparticles may also lead to long-time stabilization of sensor molecules upon repeated uses and has the potential to increase sensor performance substantially, compared to conventional layouts. This has been demonstrated in different proof-of-concept biosensor devices. Therefore, richly available plant viral particles, non-pathogenic for animals or humans, might gain novel importance if applied in receptor layers of FEDs. These perspectives are explained and discussed with regard to future detection strategies for COVID-19 and related viral diseases.}, language = {en} } @article{BialonskiHorstmannLehnertz2010, author = {Bialonski, Stephan and Horstmann, Marie-Therese and Lehnertz, Klaus}, title = {From brain to earth and climate systems: Small-world interaction networks or not?}, series = {Chaos: An Interdisciplinary Journal of Nonlinear Science}, volume = {20}, journal = {Chaos: An Interdisciplinary Journal of Nonlinear Science}, number = {1}, publisher = {AIP Publishing}, address = {Melville, NY}, issn = {1089-7682}, doi = {10.1063/1.3360561}, pages = {013134}, year = {2010}, abstract = {We consider recent reports on small-world topologies of interaction networks derived from the dynamics of spatially extended systems that are investigated in diverse scientific fields such as neurosciences, geophysics, or meteorology. With numerical simulations that mimic typical experimental situations, we have identified an important constraint when characterizing such networks: indications of a small-world topology can be expected solely due to the spatial sampling of the system along with the commonly used time series analysis based approaches to network characterization.}, language = {en} } @article{LaackHennesRefisch1987, author = {Laack, Walter van and Hennes, A. and Refisch, A.}, title = {Narkosemobilisation der Schultersteife (Periarthritis humeroscapularis ankylosans)}, series = {Zeitschrift f{\"u}r Orthop{\"a}die und Ihre Grenzgebiete. 125 (1987), H. 6}, journal = {Zeitschrift f{\"u}r Orthop{\"a}die und Ihre Grenzgebiete. 125 (1987), H. 6}, isbn = {0044-3220}, pages = {669 -- 673}, year = {1987}, language = {de} } @inproceedings{HeitzerStaat2000, author = {Heitzer, M. and Staat, Manfred}, title = {Direct FEM approach to design-by-analysis of pressurized components}, year = {2000}, abstract = {Abstracts of the ACHEMA 2000 - International Meeting on Chemical Engineering, Environmental Protection and Biotechnology, May 22 - 27, 2000. Frankfurt am Main. Achema 2000 : special edition / Linde. [Ed.: Linde AG. Red.: Volker R. Leski]. - Wiesbaden : Linde AG, 2000. - 56 p. : Ill., . - pp: 79 - 81}, subject = {Finite-Elemente-Methode}, language = {en} } @article{SchindlerBialonskiHorstmannetal.2008, author = {Schindler, Kaspar A. and Bialonski, Stephan and Horstmann, Marie-Therese and Elger, Christian E. and Lehnertz, Klaus}, title = {Evolving functional network properties and synchronizability during human epileptic seizures}, series = {Chaos: An Interdisciplinary Journal of Nonlinear Science}, volume = {18}, journal = {Chaos: An Interdisciplinary Journal of Nonlinear Science}, number = {3}, issn = {1089-7682}, doi = {10.1063/1.2966112}, pages = {033119}, year = {2008}, language = {en} } @article{SchusserLeinhosBaeckeretal.2013, author = {Schusser, Sebastian and Leinhos, Marcel and B{\"a}cker, Matthias and Poghossian, Arshak and Wagner, Patrick and Sch{\"o}ning, Michael Josef}, title = {Impedance spectroscopy: A tool for real-time in situ monitoring of the degradation of biopolymers}, series = {Physica Status Solidi (A)}, volume = {210}, journal = {Physica Status Solidi (A)}, number = {5}, publisher = {Wiley}, address = {Weinheim}, issn = {1521-396X ; 0031-8965}, doi = {10.1002/pssa.201200941}, pages = {905 -- 910}, year = {2013}, abstract = {Investigation of the degradation kinetics of biodegradable polymers is essential for the development of implantable biomedical devices with predicted biodegradability. In this work, an impedimetric sensor has been applied for real-time and in situ monitoring of degradation processes of biopolymers. The sensor consists of two platinum thin-film electrodes covered by a polymer film to be studied. The benchmark biomedical polymer poly(D,L-lactic acid) (PDLLA) was used as a model system. PDLLA films were deposited on the sensor structure from a polymer solution by using the spin-coating method. The degradation kinetics of PDLLA films have been studied in alkaline solutions of pH 9 and 12 by means of an impedance spectroscopy (IS) method. Any changes in a polymer capacitance/resistance induced by water uptake and/or polymer degradation will modulate the global impedance of the polymer-covered sensor that can be used as an indicator of the polymer degradation. The degradation rate can be evaluated from the time-dependent impedance spectra. As expected, a faster degradation has been observed for PDLLA films exposed to pH 12 solution.}, language = {en} } @article{PoghossianBerndsenLuethetal.2002, author = {Poghossian, Arshak and Berndsen, L. and L{\"u}th, H. and Schultze, J. W. and Sch{\"o}ning, Michael Josef}, title = {Multi-Parameter-Detektions-System unter dem Einsatz eines einzigen Transducerprinzips sowohl f{\"u}r (bio-)chemische als auch physikalische Sensoren}, series = {Sensoren und Mess-Systeme : Vortr{\"a}ge der 11. ITG/GMA-Fachtagung vom 11. bis 12. M{\"a}rz 2002 in Ludwigsburg / Veranst.: Informationstechnische Gesellschaft im VDE (ITG) ... Wiss. Tagungsleitung: C. D. Kohl ....}, journal = {Sensoren und Mess-Systeme : Vortr{\"a}ge der 11. ITG/GMA-Fachtagung vom 11. bis 12. M{\"a}rz 2002 in Ludwigsburg / Veranst.: Informationstechnische Gesellschaft im VDE (ITG) ... Wiss. Tagungsleitung: C. D. Kohl ....}, publisher = {VDE-Verl.}, address = {Berlin [u.a.]}, isbn = {3-8007-2675-0}, pages = {137 -- 140}, year = {2002}, language = {de} } @article{GrajewskiKoesterTurek2009, author = {Grajewski, Matthias and K{\"o}ster, Michael and Turek, Stefan}, title = {Mathematical and Numerical Analysis of a Robust and Efficient Grid Deformation Method in the Finite Element Context}, series = {SIAM Journal on Scientific Computing}, volume = {31}, journal = {SIAM Journal on Scientific Computing}, number = {2}, publisher = {Society for Industrial and Applied Mathematics}, address = {Philadelphia, Pa.}, doi = {10.1137/050639387}, pages = {1539 -- 1557}, year = {2009}, language = {en} } @article{StaatBallmann1989, author = {Staat, Manfred and Ballmann, J.}, title = {Zur Problematik tensorieller Verallgemeinerungen einachsiger nichtlinearer Materialgesetze}, series = {Zeitschrift f{\"u}r angewandte Mathematik und Mechanik : ZAMM. 69 (1989), H. 2}, journal = {Zeitschrift f{\"u}r angewandte Mathematik und Mechanik : ZAMM. 69 (1989), H. 2}, isbn = {0946-8463}, doi = {10.1515/9783112553169-006}, pages = {73 -- 81}, year = {1989}, language = {de} } @article{AimenovaDigelEshibaev2016, author = {Aimenova, Zh. E. and Digel, Ilya and Eshibaev, А. А.}, title = {Dynamics of accumulation of lagochirzin in Lagochilus setulosus phytomass during the growing season and also features of its cultivation in the conditions of a typical sierozem}, series = {KazNU Bulletin. Biology series}, volume = {69}, journal = {KazNU Bulletin. Biology series}, number = {4}, publisher = {Al-Farabi Kazakh National University}, address = {Almaty}, issn = {1563-0218}, pages = {4 -- 11}, year = {2016}, abstract = {L.setulosus is offered for creation of biopreparation «Setulin», possesing he- mostatic action, the basic reactant of biopreparation is diterpen - lagochirzin. Results under the maintenance and dynamics of diterpen lagochirzin accumula- tion in various parts of L.setulosus are presented: in roots, stalks, leaves, flowers and calyx lobes during the growing season, and also results on conditions of cultivation L.setulosus in the conditions of a typical sierozem are resulted. From the obtained data is visible, that the given species of a plant is endemic. It is established, that dynamics of accumulation of lagochirzin in phytomass accrues from the beginning to the middle of the growing season. The chemical analysis of L.setulosus on a localization of lagochirzin in various organs of a plant, has shown, that the greatest quantity of lagochirzin collects in calyx lobes of the plants. Also it is established, that L.setulosus can be cultivated in the conditions of the typical sierozem, a mineral food is necessary for the given species of plants of Lagochilus genus, except nitric fertilizers. Comparative studying of wild-growing and cultural forms of L.setulosus has shown, that in the cultivated phytomass of plants the maintenance of lagochirzin on 17-20 \% higher than in the wild-growing species.}, language = {en} } @article{BaeckerPoghossianSchoeningetal.2010, author = {B{\"a}cker, Matthias and Poghossian, Arshak and Sch{\"o}ning, Michael Josef and Schnitzler, Thomas and Biselli, Manfred and Zang, Werner and Wagner, P.}, title = {Entwicklung eines modularen festk{\"o}rperbasierten Sensorsystems f{\"u}r die {\"U}berwachung von Zellkulturfermentationen}, series = {Sensoren und Messsysteme 2010 [Elektronische Ressource] : Vortr{\"a}ge der 15. ITG/GMA-Fachtagung vom 18. bis 19. Mai 2010 in N{\"u}rnberg / Informationstechnische Gesellschaft im VDE (ITG); VDI/VDE-Gesellschaft Mess- und Automatisierungstechnik (GMA)}, journal = {Sensoren und Messsysteme 2010 [Elektronische Ressource] : Vortr{\"a}ge der 15. ITG/GMA-Fachtagung vom 18. bis 19. Mai 2010 in N{\"u}rnberg / Informationstechnische Gesellschaft im VDE (ITG); VDI/VDE-Gesellschaft Mess- und Automatisierungstechnik (GMA)}, publisher = {VDE Verlag}, address = {Berlin}, isbn = {978-3-8007-3260-9}, pages = {688 -- 698}, year = {2010}, language = {de} } @book{SchoeningPoghossian2018, author = {Sch{\"o}ning, Michael Josef and Poghossian, Arshak}, title = {Label-free biosensing: advanced materials, devices and applications}, publisher = {Springer}, address = {Cham}, isbn = {978-3-319-75219-8}, pages = {xii, 480 Seiten ; Illustrationen, Diagramme}, year = {2018}, language = {en} } @article{AkimbekovDigelSavitkayaetal.2013, author = {Akimbekov, Nuraly S. and Digel, Ilya and Savitkaya, I.S. and Zhubanova, A.A. and Tastambek, K.T.}, title = {Investigations of LPS endotoxin elimination in the flowing column conditions with the sorbent on the basis of carbonized rice husk}, series = {KazNU Bulletin. Biology series}, volume = {57}, journal = {KazNU Bulletin. Biology series}, number = {1}, issn = {1563-0218}, pages = {124 -- 127}, year = {2013}, language = {en} } @article{LaackRefisch1989, author = {Laack, Walter van and Refisch, A.}, title = {Die neuralgische Amyotrophie des Lumbalbereiches / Refisch, A. ; Laack, W. van}, series = {Orthop{\"a}dische Praxis. 7 (1989)}, journal = {Orthop{\"a}dische Praxis. 7 (1989)}, isbn = {0030-588x}, pages = {437}, year = {1989}, language = {de} } @article{LaackOhnsorge1987, author = {Laack, Walter van and Ohnsorge, J.}, title = {Technik und Ergebnisse der arthroskopischen Fixation von Dissekaten an der medialen Femurrolle mit resorbierbaren EthipinR-Stiften}, series = {Abstracts : SICOT 87, XVII. world congress, Munich, 16 - 21 August 1987 / [ed.: H. Wagner]}, journal = {Abstracts : SICOT 87, XVII. world congress, Munich, 16 - 21 August 1987 / [ed.: H. Wagner]}, publisher = {Demeter}, address = {Gr{\"a}felfing}, isbn = {3-921512-85-9}, pages = {277}, year = {1987}, language = {de} } @article{BialonskiWellmerElgeretal.2006, author = {Bialonski, Stephan and Wellmer, J{\"o}rg and Elger, Christian E. and Lehnertz, Klaus}, title = {Interictal focus localization in neocortical lesional epilepsies with synchronization cluster analysis}, series = {Epilepsia}, volume = {47}, journal = {Epilepsia}, issn = {0013-9580}, pages = {36}, year = {2006}, language = {en} } @book{Laack2005, author = {Laack, Walter van}, title = {Mit Logik die Welt begreifen}, publisher = {van Laack}, address = {Aachen}, isbn = {978-3-936624-07-6}, pages = {380 S. : Ill., graph. Darst.}, year = {2005}, language = {de} } @book{Laack2003, author = {Laack, Walter van}, title = {A better history of our world / Vol. 3. Death}, publisher = {van Laack}, address = {Aachen}, isbn = {978-3-936624-01-4}, pages = {276 S.}, year = {2003}, language = {en} } @article{LaackRefischOhnsorgeetal.1984, author = {Laack, Walter van and Refisch, A. and Ohnsorge, J. and D{\"u}rselen, L.}, title = {Proximaler Femurteilersatz - Alternative zum Schaftwechsel zementfixierter H{\"u}ftendoprothesen}, series = {Orthop{\"a}dische Praxis. 20 (1984), H. 11}, journal = {Orthop{\"a}dische Praxis. 20 (1984), H. 11}, isbn = {0030-588x}, pages = {856}, year = {1984}, language = {de} } @article{Staat1996, author = {Staat, Manfred}, title = {Problems and Chances for Probabilistic Fracture Mechanics in the Analysis of Steel Pressure Boundary Reliability}, series = {Technical feasibility and reliability of passive safety systems for nuclear power plants. Proceedings of an Advisory Group Meeting held in J{\"u}lich, 21-24 November 1994}, journal = {Technical feasibility and reliability of passive safety systems for nuclear power plants. Proceedings of an Advisory Group Meeting held in J{\"u}lich, 21-24 November 1994}, address = {Vienna}, pages = {43 -- 55}, year = {1996}, language = {en} } @article{Stulpe1988, author = {Stulpe, Werner}, title = {Conditional Expectations, Conditional Distributions, and A Posteriori Ensembles in Generalized Probability Theory}, series = {International Journal of Theoretical Physics. 27 (1988), H. 5}, journal = {International Journal of Theoretical Physics. 27 (1988), H. 5}, isbn = {1572-9575}, pages = {587 -- 611}, year = {1988}, language = {en} } @article{Laack1986, author = {Laack, Walter van}, title = {Allgemeine physiotherapeutische Behandlung nach H{\"u}ft- und Kniegelenkoperationen}, series = {Physiotherapie. 77 (1986), H. 2}, journal = {Physiotherapie. 77 (1986), H. 2}, isbn = {0031-9392}, pages = {68 -- 72}, year = {1986}, language = {de} } @article{JanusAchtsnichtDrinicetal.2023, author = {Janus, Kevin Alexander and Achtsnicht, Stefan and Drinic, Aleksander and Kopp, Alexander and Keusgen, Michael and Sch{\"o}ning, Michael Josef}, title = {Transient magnesium-based thin-film temperature sensor on a flexible, bioabsorbable substrate for future medical applications}, series = {Applied Research}, journal = {Applied Research}, number = {Accepted manuscript}, publisher = {Wiley-VCH}, issn = {2702-4288 (Print)}, doi = {10.1002/appl.202300102}, pages = {22 Seiten}, year = {2023}, abstract = {In this work, the bioabsorbable materials, namely fibroin, polylactide acid (PLA), magnesium and magnesium oxide are investigated for their application as transient, resistive temperature detectors (RTD). For this purpose, a thin-film magnesium-based meander-like electrode is deposited onto a flexible, bioabsorbable substrate (fibroin or PLA) and encapsulated (passivated) by additional magnesium oxide layers on top and below the magnesium-based electrode. The morphology of different layered RTDs is analyzed by scanning electron microscopy. The sensor performance and lifetime of the RTD is characterized both under ambient atmospheric conditions between 30°C and 43°C, and wet tissue-like conditions with a constant temperature regime of 37°C. The latter triggers the degradation process of the magnesium-based layers. The 3-layers RTDs on a PLA substrate could achieve a lifetime of 8.5 h. These sensors also show the best sensor performance under ambient atmospheric conditions with a mean sensitivity of 0.48 Ω/°C ± 0.01 Ω/°C.}, language = {en} } @article{JanusAchtsnichtTempeletal.2023, author = {Janus, Kevin Alexander and Achtsnicht, Stefan and Tempel, Laura and Drinic, Aleksaner and Kopp, Alexander and Keusgen, Michael and Sch{\"o}ning, Michael Josef}, title = {Influence of fibroin membrane composition and curing parameters on the performance of a biodegradable enzymatic biosensor manufactured from Silicon-Free Carbon}, series = {Physica status solidi : pss. A, Applications and materials science}, volume = {220}, journal = {Physica status solidi : pss. A, Applications and materials science}, number = {22}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1862-6300 (Print)}, doi = {10.1002/pssa.202300081}, pages = {10 Seiten}, year = {2023}, abstract = {Herein, fibroin, polylactide (PLA), and carbon are investigated for their suitability as biocompatible and biodegradable materials for amperometric biosensors. For this purpose, screen-printed carbon electrodes on the biodegradable substrates fibroin and PLA are modified with a glucose oxidase membrane and then encapsulated with the biocompatible material Ecoflex. The influence of different curing parameters of the carbon electrodes on the resulting biosensor characteristics is studied. The morphology of the electrodes is investigated by scanning electron microscopy, and the biosensor performance is examined by amperometric measurements of glucose (0.5-10 mM) in phosphate buffer solution, pH 7.4, at an applied potential of 1.2 V versus a Ag/AgCl reference electrode. Instead of Ecoflex, fibroin, PLA, and wound adhesive are tested as alternative encapsulation compounds: a series of swelling tests with different fibroin compositions, PLA, and Ecoflex has been performed before characterizing the most promising candidates by chronoamperometry. Therefore, the carbon electrodes are completely covered with the particular encapsulation material. Chronoamperometric measurements with H2O2 concentrations between 0.5 and 10 mM enable studying the leakage current behavior.}, language = {en} } @phdthesis{Achtsnicht2020, author = {Achtsnicht, Stefan}, title = {Multiplex-Magnetdetektion von superparamagnetischen Beads zur Identifizierung von Trinkwasserkontaminationen}, doi = {10.18154/RWTH-2020-12052}, pages = {144 Seiten}, year = {2020}, abstract = {Die qualitative und quantitative Detektion von Zielsubstanzen innerhalb einer w{\"a}ssrigen Probe ist f{\"u}r viele Fragestellungen von Interesse, etwa bei der Detektion von Kontaminationen in Trinkwasser in Krisensituationen. Hierbei ist es nicht nur wichtig, dass Pathogene m{\"o}glichst sensitiv detektiert werden k{\"o}nnen, sondern auch, dass die Analyse schnell erfolgt, um Betroffenen im Katastrophenfall z{\"u}gig sicheres Trinkwasser zu Verf{\"u}gung stellen zu k{\"o}nnen. Da bei einem solchen Szenario nicht von einer in der N{\"a}he befindlichen funktionierenden Laborinfrastruktur ausgegangen werden kann, ist es wichtig, dass die Messung direkt vor Ort erfolgen kann. Im Rahmen dieser Arbeit wurde untersucht, ob eine derartige Schnellanalytik mithilfe von superparamagnetischen Beads (MBs) und der magnetischen Frequenzmischtechnik m{\"o}glich ist. Dabei werden die MBs mit Hilfe von prim{\"a}ren Antik{\"o}rpern an die Zielsubstanz gebunden und mit sekund{\"a}ren Antik{\"o}rpern an die Poren-Oberfl{\"a}che eines Polyethylen-Filters fixiert (Sandwich-Immunoassay). So kann die Quantifizierung der Zielsubstanz auf eine magnetische Messung der immobilisierten MB-Marker zur{\"u}ckgef{\"u}hrt werden. Die magnetische Frequenzmischtechnik basiert auf der Anregung der Probe mit Magnetfeldern zweier verschiedener Frequenzen. Die durch die nichtlineare Magnetisierungsform der superparamagnetischen MBs entstehenden Mischfrequenzen werden typischerweise mithilfe einer zweistufigen Lock-in-Detektion analysiert (analoge Demodulation), die in einem Magnetreader als Handheldger{\"a}t realisiert wurde. Zus{\"a}tzlich zu dieser Technik wurde das Prinzip der direkten Digitalisierung des gesamten Antwortsignals mit anschließender Fourier-Analyse der erzeugten Mischfrequenzen experimentell umgesetzt, um die Amplituden und Phasen mehrerer Mischfrequenzen simultan zu erfassen. Eine M{\"o}glichkeit zur Sensitivit{\"a}tssteigerung ist die magnetische Aufkonzentration, indem vor der magnetischen Analyse eine Separation der MBs aus einem gr{\"o}ßeren Probenvolumen mittels magnetischem Feldgradienten durchgef{\"u}hrt wird. Zur Charakterisierung verschiedener kommerzieller MBs hinsichtlich ihrer magnetischen Separierbarkeit wurde ein Aufbau zur Messung ihrer magnetophoretischen Beweglichkeiten realisiert und ihre Geschwindigkeiten im Gradientenfeld mikroskopisch gemessen.Da eine Probe oftmals nicht nur auf eine einzige Zielsubstanz, sondern simultan auf mehrere verschiedene Pathogene hin untersucht werden soll, wurden verschiedene Ans{\"a}tze entwickelt und getestet, die einen solchen multiparametrischen magnetischen Immunoassay erm{\"o}glichen. Einerseits wurde eine r{\"a}umliche Separation der Bindungsbereiche f{\"u}r verschiedene Zielsubstanzen realisiert, die sequentiell ausgewertet werden k{\"o}nnen. Andererseits wurde die Unterscheidung von verschiedenen Zielsubstanzen anhand der Charakteristika der an sie gebundenen, verschieden funktionalisierten MB-Typen untersucht. F{\"u}r eine solche Unterscheidung wurde zum einen die Anregefrequenz der magnetischen Frequenzmischtechnik w{\"a}hrend einer Messung variiert. Damit konnte gezeigt werden, dass sich verschiedene MB-Sorten anhand der Phase ihrer Frequenzmischsignale voneinander unterscheiden lassen. Weiterhin wurde gezeigt, dass sich der Signalverlauf einer bin{\"a}ren Mischung zweier verschiedener MB-Typen als gradueller {\"U}bergang der Verl{\"a}ufe der beiden reinen MB-L{\"o}sungen ergibt. Eine weitere Analysemethode f{\"u}r einen multiparametrischen Immunoassay besteht darin, ein zus{\"a}tzliches einstellbares statisches magnetisches Offsetfeld zu verwenden. Hierf{\"u}r wurden mehrere Aufbauten auf Basis von Permanent- und Elektromagneten simuliert, konstruiert und charakterisiert. Mithilfe von Simulationen konnte gezeigt werden, dass eine auf diesem Verfahren beruhende Unterscheidung f{\"u}r MBs mit unterschiedlichen magnetischen Partikelmomenten m{\"o}glich ist. Als direkte Anwendung des hier entwickelten Magnetreaders in Zusammenspiel mit der digitalen Demodulation wurde ein magnetischer Assay gegen die B-Untereinheit des Choleratoxins in Trinkwasser mit einem niedrigen Detektionslimit von 0,2 ng/ml demonstriert.}, language = {de} } @article{KarschuckPoghossianSeretal.2024, author = {Karschuck, Tobias and Poghossian, Arshak and Ser, Joey and Tsokolakyan, Astghik and Achtsnicht, Stefan and Wagner, Patrick and Sch{\"o}ning, Michael Josef}, title = {Capacitive model of enzyme-modified field-effect biosensors: Impact of enzyme coverage}, series = {Sensors and Actuators B: Chemical}, volume = {408}, journal = {Sensors and Actuators B: Chemical}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0925-4005 (Print)}, doi = {10.1016/j.snb.2024.135530}, pages = {12 Seiten}, year = {2024}, abstract = {Electrolyte-insulator-semiconductor capacitors (EISCAP) belong to field-effect sensors having an attractive transducer architecture for constructing various biochemical sensors. In this study, a capacitive model of enzyme-modified EISCAPs has been developed and the impact of the surface coverage of immobilized enzymes on its capacitance-voltage and constant-capacitance characteristics was studied theoretically and experimentally. The used multicell arrangement enables a multiplexed electrochemical characterization of up to sixteen EISCAPs. Different enzyme coverages have been achieved by means of parallel electrical connection of bare and enzyme-covered single EISCAPs in diverse combinations. As predicted by the model, with increasing the enzyme coverage, both the shift of capacitance-voltage curves and the amplitude of the constant-capacitance signal increase, resulting in an enhancement of analyte sensitivity of the EISCAP biosensor. In addition, the capability of the multicell arrangement with multi-enzyme covered EISCAPs for sequentially detecting multianalytes (penicillin and urea) utilizing the enzymes penicillinase and urease has been experimentally demonstrated and discussed.}, language = {en} } @article{MolinnusJanusFangetal.2022, author = {Molinnus, Denise and Janus, Kevin Alexander and Fang, Anyelina C. and Drinic, Aleksander and Achtsnicht, Stefan and K{\"o}pf, Marius and Keusgen, Michael and Sch{\"o}ning, Michael Josef}, title = {Thick-film carbon electrode deposited onto a biodegradable fibroin substrate for biosensing applications}, series = {Physica status solidi (a)}, volume = {219}, journal = {Physica status solidi (a)}, number = {23}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1862-6319}, doi = {10.1002/pssa.202200100}, pages = {1 -- 9}, year = {2022}, abstract = {This study addresses a proof-of-concept experiment with a biocompatible screen-printed carbon electrode deposited onto a biocompatible and biodegradable substrate, which is made of fibroin, a protein derived from silk of the Bombyx mori silkworm. To demonstrate the sensor performance, the carbon electrode is functionalized as a glucose biosensor with the enzyme glucose oxidase and encapsulated with a silicone rubber to ensure biocompatibility of the contact wires. The carbon electrode is fabricated by means of thick-film technology including a curing step to solidify the carbon paste. The influence of the curing temperature and curing time on the electrode morphology is analyzed via scanning electron microscopy. The electrochemical characterization of the glucose biosensor is performed by amperometric/voltammetric measurements of different glucose concentrations in phosphate buffer. Herein, systematic studies at applied potentials from 500 to 1200 mV to the carbon working electrode (vs the Ag/AgCl reference electrode) allow to determine the optimal working potential. Additionally, the influence of the curing parameters on the glucose sensitivity is examined over a time period of up to 361 days. The sensor shows a negligible cross-sensitivity toward ascorbic acid, noradrenaline, and adrenaline. The developed biocompatible biosensor is highly promising for future in vivo and epidermal applications.}, language = {en} } @article{OezsoyluKizildagSchoeningetal.2020, author = {{\"O}zsoylu, Dua and Kizildag, Sefa and Sch{\"o}ning, Michael Josef and Wagner, Torsten}, title = {Differential chemical imaging of extracellular acidification within microfluidic channels using a plasma-functionalized light-addressable potentiometric sensor (LAPS)}, series = {Physics in Medicine}, volume = {10}, journal = {Physics in Medicine}, number = {100030}, publisher = {Elsevier}, address = {Amsterdam}, issn = {2352-4510}, doi = {10.1016/j.phmed.2020.100030}, pages = {8}, year = {2020}, abstract = {Extracellular acidification is a basic indicator for alterations in two vital metabolic pathways: glycolysis and cellular respiration. Measuring these alterations by monitoring extracellular acidification using cell-based biosensors such as LAPS plays an important role in studying these pathways whose disorders are associated with numerous diseases including cancer. However, the surface of the biosensors must be specially tailored to ensure high cell compatibility so that cells can represent more in vivo-like behavior, which is critical to gain more realistic in vitro results from the analyses, e.g., drug discovery experiments. In this work, O2 plasma patterning on the LAPS surface is studied to enhance surface features of the sensor chip, e.g., wettability and biofunctionality. The surface treated with O2 plasma for 30 s exhibits enhanced cytocompatibility for adherent CHO-K1 cells, which promotes cell spreading and proliferation. The plasma-modified LAPS chip is then integrated into a microfluidic system, which provides two identical channels to facilitate differential measurements of the extracellular acidification of CHO-K1 cells. To the best of our knowledge, it is the first time that extracellular acidification within microfluidic channels is quantitatively visualized as differential (bio-)chemical images.}, language = {en} } @inproceedings{SildatkeKarwanniKraftetal.2020, author = {Sildatke, Michael and Karwanni, Hendrik and Kraft, Bodo and Schmidts, Oliver and Z{\"u}ndorf, Albert}, title = {Automated Software Quality Monitoring in Research Collaboration Projects}, series = {ICSEW'20: Proceedings of the IEEE/ACM 42nd International Conference on Software Engineering Workshops}, booktitle = {ICSEW'20: Proceedings of the IEEE/ACM 42nd International Conference on Software Engineering Workshops}, publisher = {IEEE}, address = {New York, NY}, doi = {10.1145/3387940.3391478}, pages = {603 -- 610}, year = {2020}, abstract = {In collaborative research projects, both researchers and practitioners work together solving business-critical challenges. These projects often deal with ETL processes, in which humans extract information from non-machine-readable documents by hand. AI-based machine learning models can help to solve this problem. Since machine learning approaches are not deterministic, their quality of output may decrease over time. This fact leads to an overall quality loss of the application which embeds machine learning models. Hence, the software qualities in development and production may differ. Machine learning models are black boxes. That makes practitioners skeptical and increases the inhibition threshold for early productive use of research prototypes. Continuous monitoring of software quality in production offers an early response capability on quality loss and encourages the use of machine learning approaches. Furthermore, experts have to ensure that they integrate possible new inputs into the model training as quickly as possible. In this paper, we introduce an architecture pattern with a reference implementation that extends the concept of Metrics Driven Research Collaboration with an automated software quality monitoring in productive use and a possibility to auto-generate new test data coming from processed documents in production. Through automated monitoring of the software quality and auto-generated test data, this approach ensures that the software quality meets and keeps requested thresholds in productive use, even during further continuous deployment and changing input data.}, language = {en} } @article{EngelmannPourshahidiShalabyetal.2022, author = {Engelmann, Ulrich M. and Pourshahidi, Mohammad Ali and Shalaby, Ahmed and Krause, Hans-Joachim}, title = {Probing particle size dependency of frequency mixing magnetic detection with dynamic relaxation simulation}, series = {Journal of Magnetism and Magnetic Materials}, volume = {563}, journal = {Journal of Magnetism and Magnetic Materials}, number = {In progress, Art. No. 169965}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0304-8853}, doi = {10.1016/j.jmmm.2022.169965}, year = {2022}, abstract = {Biomedical applications of magnetic nanoparticles (MNP) fundamentally rely on the particles' magnetic relaxation as a response to an alternating magnetic field. The magnetic relaxation complexly depends on the interplay of MNP magnetic and physical properties with the applied field parameters. It is commonly accepted that particle core size is a major contributor to signal generation in all the above applications, however, most MNP samples comprise broad distribution spanning nm and more. Therefore, precise knowledge of the exact contribution of individual core sizes to signal generation is desired for optimal MNP design generally for each application. Specifically, we present a magnetic relaxation simulation-driven analysis of experimental frequency mixing magnetic detection (FMMD) for biosensing to quantify the contributions of individual core size fractions towards signal generation. Applying our method to two different experimental MNP systems, we found the most dominant contributions from approx. 20 nm sized particles in the two independent MNP systems. Additional comparison between freely suspended and immobilized MNP also reveals insight in the MNP microstructure, allowing to use FMMD for MNP characterization, as well as to further fine-tune its applicability in biosensing.}, language = {en} } @article{AchtsnichtToedterNiehuesetal.2019, author = {Achtsnicht, Stefan and T{\"o}dter, Julia and Niehues, Julia and Tel{\"o}ken, Matthias and Offenh{\"a}usser, Andreas and Krause, Hans-Joachim and Schr{\"o}per, Florian}, title = {3D printed modular immunofiltration columns for frequency mixing-based multiplex magnetic immunodetection}, series = {Sensors}, volume = {19}, journal = {Sensors}, number = {1}, publisher = {MDPI}, address = {Basel}, issn = {1424-8220}, doi = {10.3390/s19010148}, pages = {15 Seiten}, year = {2019}, abstract = {For performing point-of-care molecular diagnostics, magnetic immunoassays constitute a promising alternative to established enzyme-linked immunosorbent assays (ELISA) because they are fast, robust and sensitive. Simultaneous detection of multiple biomolecular targets from one body fluid sample is desired. The aim of this work is to show that multiplex magnetic immunodetection based on magnetic frequency mixing by means of modular immunofiltration columns prepared for different targets is feasible. By calculations of the magnetic response signal, the required spacing between the modules was determined. Immunofiltration columns were manufactured by 3D printing and antibody immobilization was performed in a batch approach. It was shown experimentally that two different target molecules in a sample solution could be individually detected in a single assaying step with magnetic measurements of the corresponding immobilization filters. The arrangement order of the filters and of a negative control did not influence the results. Thus, a simple and reliable approach to multi-target magnetic immunodetection was demonstrated.}, language = {en} } @article{EngelmannShalabyShashaetal.2021, author = {Engelmann, Ulrich M. and Shalaby, Ahmed and Shasha, Carolyn and Krishnan, Kannan M. and Krause, Hans-Joachim}, title = {Comparative modeling of frequency mixing measurements of magnetic nanoparticles using micromagnetic simulations and Langevin theory}, series = {Nanomaterials}, volume = {11}, journal = {Nanomaterials}, number = {5}, publisher = {MDPI}, address = {Basel}, isbn = {2079-4991}, doi = {10.3390/nano11051257}, pages = {1 -- 16}, year = {2021}, abstract = {Dual frequency magnetic excitation of magnetic nanoparticles (MNP) enables enhanced biosensing applications. This was studied from an experimental and theoretical perspective: nonlinear sum-frequency components of MNP exposed to dual-frequency magnetic excitation were measured as a function of static magnetic offset field. The Langevin model in thermodynamic equilibrium was fitted to the experimental data to derive parameters of the lognormal core size distribution. These parameters were subsequently used as inputs for micromagnetic Monte-Carlo (MC)-simulations. From the hysteresis loops obtained from MC-simulations, sum-frequency components were numerically demodulated and compared with both experiment and Langevin model predictions. From the latter, we derived that approximately 90\% of the frequency mixing magnetic response signal is generated by the largest 10\% of MNP. We therefore suggest that small particles do not contribute to the frequency mixing signal, which is supported by MC-simulation results. Both theoretical approaches describe the experimental signal shapes well, but with notable differences between experiment and micromagnetic simulations. These deviations could result from Brownian relaxations which are, albeit experimentally inhibited, included in MC-simulation, or (yet unconsidered) cluster-effects of MNP, or inaccurately derived input for MC-simulations, because the largest particles dominate the experimental signal but concurrently do not fulfill the precondition of thermodynamic equilibrium required by Langevin theory.}, language = {en} } @article{AliaziziOezsoyluBakhshiSichanietal.2024, author = {Aliazizi, Fereshteh and {\"O}zsoylu, Dua and Bakhshi Sichani, Soroush and Khorshid, Mehran and Glorieux, Christ and Robbens, Johan and Sch{\"o}ning, Michael Josef and Wagner, Patrick}, title = {Development and Calibration of a Microfluidic, Chip-Based Sensor System for Monitoring the Physical Properties of Water Samples in Aquacultures}, series = {Micromachines}, volume = {15}, journal = {Micromachines}, number = {6}, publisher = {MDPI}, address = {Basel}, issn = {2072-666X}, doi = {10.3390/mi15060755}, year = {2024}, abstract = {In this work, we present a compact, bifunctional chip-based sensor setup that measures the temperature and electrical conductivity of water samples, including specimens from rivers and channels, aquaculture, and the Atlantic Ocean. For conductivity measurements, we utilize the impedance amplitude recorded via interdigitated electrode structures at a single triggering frequency. The results are well in line with data obtained using a calibrated reference instrument. The new setup holds for conductivity values spanning almost two orders of magnitude (river versus ocean water) without the need for equivalent circuit modelling. Temperature measurements were performed in four-point geometry with an on-chip platinum RTD (resistance temperature detector) in the temperature range between 2 °C and 40 °C, showing no hysteresis effects between warming and cooling cycles. Although the meander was not shielded against the liquid, the temperature calibration provided equivalent results to low conductive Milli-Q and highly conductive ocean water. The sensor is therefore suitable for inline and online monitoring purposes in recirculating aquaculture systems.}, language = {en} } @article{ZhantlessovaSavitskayaKistaubayevaetal.2024, author = {Zhantlessova, Sirina and Savitskaya, Irina and Kistaubayeva, Aida and Ignatova, Ludmila and Talipova, Aizhan and Pogrebnjak, Alexander and Digel, Ilya}, title = {Correction: Zhantlessova et al. advanced "Green" prebiotic composite of bacterial cellulose/pullulan based on synthetic biology-powered microbial coculture strategy. Polymers 2022, 14, 3224}, series = {Polymers}, volume = {16}, journal = {Polymers}, number = {13}, publisher = {MDPI}, address = {Basel}, issn = {2073-4360}, doi = {10.3390/polym16131802}, pages = {2 Seiten}, year = {2024}, language = {en} } @article{HarrisKleefeld2022, author = {Harris, Isaac and Kleefeld, Andreas}, title = {Analysis and computation of the transmission eigenvalues with a conductive boundary condition}, series = {Applicable Analysis}, volume = {101}, journal = {Applicable Analysis}, number = {6}, publisher = {Taylor \& Francis}, address = {London}, issn = {1563-504X}, doi = {10.1080/00036811.2020.1789598}, pages = {1880 -- 1895}, year = {2022}, abstract = {We provide a new analytical and computational study of the transmission eigenvalues with a conductive boundary condition. These eigenvalues are derived from the scalar inverse scattering problem for an inhomogeneous material with a conductive boundary condition. The goal is to study how these eigenvalues depend on the material parameters in order to estimate the refractive index. The analytical questions we study are: deriving Faber-Krahn type lower bounds, the discreteness and limiting behavior of the transmission eigenvalues as the conductivity tends to infinity for a sign changing contrast. We also provide a numerical study of a new boundary integral equation for computing the eigenvalues. Lastly, using the limiting behavior we will numerically estimate the refractive index from the eigenvalues provided the conductivity is sufficiently large but unknown.}, language = {en} } @inproceedings{JabbariBhattaraiAndingetal.2017, author = {Jabbari, Medisa and Bhattarai, Aroj and Anding, Ralf and Staat, Manfred}, title = {Biomechanical simulation of different prosthetic meshes for repairing uterine/vaginal vault prolapse}, series = {2nd YRA MedTech Symposium 2017 : June 8th - 9th / 2017 / Hochschule Ruhr-West}, booktitle = {2nd YRA MedTech Symposium 2017 : June 8th - 9th / 2017 / Hochschule Ruhr-West}, editor = {Erni, Daniel and Fischerauer, Alice and Himmel, J{\"o}rg and Seeger, Thomas and Thelen, Klaus}, publisher = {Universit{\"a}t Duisburg-Essen}, address = {Duisburg}, organization = {MedTech Symposium}, isbn = {978-3-9814801-9-1}, doi = {10.17185/duepublico/43984}, pages = {118 -- 119}, year = {2017}, language = {en} } @book{StaatDigelTrzewiketal.2024, author = {Staat, Manfred and Digel, Ilya and Trzewik, J{\"u}rgen and Sielemann, Stefanie and Erni, Daniel and Zylka, Waldemar}, title = {Symposium Proceedings; 4th YRA MedTech Symposium 2024 : February 1 / 2024 / FH Aachen}, publisher = {Universit{\"a}t Duisburg-Essen}, address = {Duisburg}, organization = {MedTech Symposium}, isbn = {978-3-940402-65-3}, doi = {10.17185/duepublico/81475}, pages = {40 Seiten}, year = {2024}, language = {en} } @inproceedings{FrotscherStaat2015, author = {Frotscher, Ralf and Staat, Manfred}, title = {Homogenization of a cardiac tissue construct}, series = {CMBE15 : 4th International Conference on Computational \& Mathematical Biomedical Engineering ; 29th June - 1st July 2015 ; {\´E}cole Normale Sup{\´e}rieure de Cachan ; Cachan (Paris), France}, booktitle = {CMBE15 : 4th International Conference on Computational \& Mathematical Biomedical Engineering ; 29th June - 1st July 2015 ; {\´E}cole Normale Sup{\´e}rieure de Cachan ; Cachan (Paris), France}, editor = {Nithiarasu, Perumal}, publisher = {CMBE}, address = {[s.l.]}, issn = {2227-9385}, pages = {645 -- 648}, year = {2015}, language = {en} } @inproceedings{SchmitzApandiSpillneretal.2024, author = {Schmitz, Annika and Apandi, Shah Eiman Amzar Shah and Spillner, Jan and Hima, Flutura and Behbahani, Mehdi}, title = {Effect of different cannula positions in the pulmonary artery on blood flow and gas exchange using computational fluid dynamics analysis}, series = {YRA MedTech Symposium (2024)}, booktitle = {YRA MedTech Symposium (2024)}, editor = {Digel, Ilya and Staat, Manfred and Trzewik, J{\"u}rgen and Sielemann, Stefanie and Erni, Daniel and Zylka, Waldemar}, publisher = {Universit{\"a}t Duisburg-Essen}, address = {Duisburg}, organization = {MedTech Symposium}, isbn = {978-3-940402-65-3}, doi = {10.17185/duepublico/81475}, pages = {29 -- 30}, year = {2024}, abstract = {Pulmonary arterial cannulation is a common and effective method for percutaneous mechanical circulatory support for concurrent right heart and respiratory failure [1]. However, limited data exists to what effect the positioning of the cannula has on the oxygen perfusion throughout the pulmonary artery (PA). This study aims to evaluate, using computational fluid dynamics (CFD), the effect of different cannula positions in the PA with respect to the oxygenation of the different branching vessels in order for an optimal cannula position to be determined. The four chosen different positions (see Fig. 1) of the cannulas are, in the lower part of the main pulmonary artery (MPA), in the MPA at the junction between the right pulmonary artery (RPA) and the left pulmonary artery (LPA), in the RPA at the first branch of the RPA and in the LPA at the first branch of the LPA.}, language = {en} } @inproceedings{KuhlenDigel2017, author = {Kuhlen, Max and Digel, Ilya}, title = {Fluorescence signatures and detection limits of ubiquitous terrestrial bio-compounds}, series = {2nd YRA MedTech Symposium 2017 : June 8th - 9th / 2017 / Hochschule Ruhr-West}, booktitle = {2nd YRA MedTech Symposium 2017 : June 8th - 9th / 2017 / Hochschule Ruhr-West}, editor = {Erni, Daniel and Fischerauer, Alice and Himmel, J{\"o}rg and Seeger, Thomas and Thelen, Klaus}, publisher = {Universit{\"a}t Duisburg-Essen}, address = {Duisburg}, organization = {MedTech Symposium}, isbn = {978-3-9814801-9-1}, doi = {10.17185/duepublico/43984}, pages = {102 -- 103}, year = {2017}, language = {en} } @inproceedings{KirchnerHenkelNaetheretal.2008, author = {Kirchner, Patrick and Henkel, H. and N{\"a}ther, Niko and Spelthahn, H. and Schneider, A. and Berger, J. and Kolstad, J. and Friedrich, P. and Sch{\"o}ning, Michael Josef}, title = {RFID-basiertes Sensorsystem zur Realisierung intelligenter Verpackungen f{\"u}r die Nahrungsmittelindustrie}, series = {KMU - innovativ: IKT 2008. CD-ROM : BMBF-Statustagung KMU - innovativ: IKT, Darmstadt, 17. - 18. Nov. 2008}, booktitle = {KMU - innovativ: IKT 2008. CD-ROM : BMBF-Statustagung KMU - innovativ: IKT, Darmstadt, 17. - 18. Nov. 2008}, number = {CD-ROM-Ausg.}, publisher = {BMBF}, address = {Berlin}, pages = {9 S.}, year = {2008}, language = {de} } @article{ZhenLiangStaatetal.2024, author = {Zhen, Manghao and Liang, Yunpei and Staat, Manfred and Li, Quanqui and Li, Jianbo}, title = {Discontinuous fracture behaviors and constitutive model of sandstone specimens containing non-parallel prefabricated fissures under uniaxial compression}, series = {Theoretical and Applied Fracture Mechanics}, volume = {131}, journal = {Theoretical and Applied Fracture Mechanics}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0167-8442}, doi = {10.1016/j.tafmec.2024.104373}, pages = {Artikel 104373}, year = {2024}, abstract = {The deformation and damage laws of non-homogeneous irregular structural planes in rocks are the basis for studying the stability of rock engineering. To investigate the damage characteristics of rock containing non-parallel fissures, uniaxial compression tests and numerical simulations were conducted on sandstone specimens containing three non-parallel fissures inclined at 0°, 45° and 90° in this study. The characteristics of crack initiation and crack evolution of fissures with different inclinations were analyzed. A constitutive model for the discontinuous fractures of fissured sandstone was proposed. The results show that the fracture behaviors of fissured sandstone specimens are discontinuous. The stress-strain curves are non-smooth and can be divided into nonlinear crack closure stage, linear elastic stage, plastic stage and brittle failure stage, of which the plastic stage contains discontinuous stress drops. During the uniaxial compression test, the middle or ends of 0° fissures were the first to crack compared to 45° and 90° fissures. The end with small distance between 0° and 45° fissures cracked first, and the end with large distance cracked later. After the final failure, 0° fissures in all specimens were fractured, while 45° and 90° fissures were not necessarily fractured. Numerical simulation results show that the concentration of compressive stress at the tips of 0°, 45° and 90° fissures, as well as the concentration of tensile stress on both sides, decreased with the increase of the inclination angle. A constitutive model for the discontinuous fractures of fissured sandstone specimens was derived by combining the logistic model and damage mechanic theory. This model can well describe the discontinuous drops of stress and agrees well with the whole processes of the stress-strain curves of the fissured sandstone specimens.}, language = {en} } @article{KeutmannStaatLaack2018, author = {Keutmann, Sabine and Staat, Manfred and Laack, Walter van}, title = {Untersuchung der thermischen Auswirkung von therapeutischem Ultraschall}, volume = {7}, number = {10}, publisher = {Deutscher {\"A}rzte-Verl.}, address = {K{\"o}ln}, issn = {2193-5793}, pages = {518 -- 522}, year = {2018}, abstract = {Zusammenfassung: In der Orthop{\"a}die z{\"a}hlt der therapeutische Ultraschall als Mittel zur Pr{\"a}vention und Therapiebegleitung. Er hat mechanische, thermische und physiko-chemische Auswirkungen auf den menschlichen K{\"o}rper. Um mehr Erkenntnisse {\"u}ber die thermischen Auswirkungen zu erlangen, wurden Versuche an einem Hydrogel-Phantom und an Probanden durchgef{\"u}hrt. Dabei entstand eine signifikante Erw{\"a}rmung des Gewebes, welche beim Probandenversuch an der Oberfl{\"a}che und beim Hydrogelversuch in der Tiefe gemessen wurde. Summary: In orthopaedics, therapeutic ultrasound is a tool of prevention and therapy support. It has mechanical, thermal and physico-chemical effects on the human body. Tests with a hydrogel phantom and with human probands have been performed in order to obtain more knowledge about their thermal effects. Both tests measured temperature increases in cell tissue, on the surface with the human proband test and in depth with the hydrogel phantom test.}, language = {de} } @article{DiktaReisselHarlass2016, author = {Dikta, Gerhard and Reißel, Martin and Harlaß, Carsten}, title = {Semi-parametric survival function estimators deduced from an identifying Volterra type integral equation}, series = {Journal of multivariate analysis}, journal = {Journal of multivariate analysis}, number = {147}, publisher = {Elsevier}, address = {Amsterdam}, doi = {10.1016/j.jmva.2016.02.008}, pages = {273 -- 284}, year = {2016}, abstract = {Based on an identifying Volterra type integral equation for randomly right censored observations from a lifetime distribution function F, we solve the corresponding estimating equation by an explicit and implicit Euler scheme. While the first approach results in some known estimators, the second one produces new semi-parametric and pre-smoothed Kaplan-Meier estimators which are real distribution functions rather than sub-distribution functions as the former ones are. This property of the new estimators is particular useful if one wants to estimate the expected lifetime restricted to the support of the observation time. Specifically, we focus on estimation under the semi-parametric random censorship model (SRCM), that is, a random censorship model where the conditional expectation of the censoring indicator given the observation belongs to a parametric family. We show that some estimated linear functionals which are based on the new semi-parametric estimator are strong consistent, asymptotically normal, and efficient under SRCM. In a small simulation study, the performance of the new estimator is illustrated under moderate sample sizes. Finally, we apply the new estimator to a well-known real dataset.}, language = {en} } @inproceedings{MarinovaKerroumiLintermannetal.2016, author = {Marinova, V. and Kerroumi, I. and Lintermann, A. and G{\"o}bbert, J.H. and Moulinec, C. and Rible, S. and Fournier, Y. and Behbahani, Mehdi}, title = {Numerical Analysis of the FDA Centrifugal Blood Pump}, series = {NIC Symposium 2016}, booktitle = {NIC Symposium 2016}, isbn = {978-3-95806-109-5}, pages = {355 -- 364}, year = {2016}, language = {de} } @article{MichaelMayerWeberetal.2017, author = {Michael, Hackl and Mayer, Katharina and Weber, Mareike and Staat, Manfred and van Riet, Roger and Burkhart, Klau Josef and M{\"u}ller, Lars Peter and Wegmann, Kilian}, title = {Plate osteosynthesis of proximal ulna fractures : a biomechanical micromotion analysis}, series = {The journal of hand surgery}, volume = {42}, journal = {The journal of hand surgery}, number = {10}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0363-5023}, doi = {10.1016/j.jhsa.2017.05.014}, pages = {834.e1 -- 834.e7}, year = {2017}, language = {en} } @article{ClausnitzerKleefeld2024, author = {Clausnitzer, Julian and Kleefeld, Andreas}, title = {A spectral Galerkin exponential Euler time-stepping scheme for parabolic SPDEs on two-dimensional domains with a C² boundary}, series = {Discrete and Continuous Dynamical Systems - Series B}, volume = {29}, journal = {Discrete and Continuous Dynamical Systems - Series B}, number = {4}, publisher = {AIMS}, address = {Springfield}, issn = {1531-3492}, doi = {10.3934/dcdsb.2023148}, pages = {1624 -- 1651}, year = {2024}, abstract = {We consider the numerical approximation of second-order semi-linear parabolic stochastic partial differential equations interpreted in the mild sense which we solve on general two-dimensional domains with a C² boundary with homogeneous Dirichlet boundary conditions. The equations are driven by Gaussian additive noise, and several Lipschitz-like conditions are imposed on the nonlinear function. We discretize in space with a spectral Galerkin method and in time using an explicit Euler-like scheme. For irregular shapes, the necessary Dirichlet eigenvalues and eigenfunctions are obtained from a boundary integral equation method. This yields a nonlinear eigenvalue problem, which is discretized using a boundary element collocation method and is solved with the Beyn contour integral algorithm. We present an error analysis as well as numerical results on an exemplary asymmetric shape, and point out limitations of the approach.}, language = {en} } @article{MartinVaqueroKleefeld2020, author = {Mart{\´i}n-Vaquero, J. and Kleefeld, Andreas}, title = {Solving nonlinear parabolic PDEs in several dimensions: Parallelized ESERK codes}, series = {Journal of Computational Physics}, journal = {Journal of Computational Physics}, number = {423}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0021-9991}, doi = {10.1016/j.jcp.2020.109771}, year = {2020}, abstract = {There is a very large number of very important situations which can be modeled with nonlinear parabolic partial differential equations (PDEs) in several dimensions. In general, these PDEs can be solved by discretizing in the spatial variables and transforming them into huge systems of ordinary differential equations (ODEs), which are very stiff. Therefore, standard explicit methods require a large number of iterations to solve stiff problems. But implicit schemes are computationally very expensive when solving huge systems of nonlinear ODEs. Several families of Extrapolated Stabilized Explicit Runge-Kutta schemes (ESERK) with different order of accuracy (3 to 6) are derived and analyzed in this work. They are explicit methods, with stability regions extended, along the negative real semi-axis, quadratically with respect to the number of stages s, hence they can be considered to solve stiff problems much faster than traditional explicit schemes. Additionally, they allow the adaptation of the step length easily with a very small cost. Two new families of ESERK schemes (ESERK3 and ESERK6) are derived, and analyzed, in this work. Each family has more than 50 new schemes, with up to 84.000 stages in the case of ESERK6. For the first time, we also parallelized all these new variable step length and variable number of stages algorithms (ESERK3, ESERK4, ESERK5, and ESERK6). These parallelized strategies allow to decrease times significantly, as it is discussed and also shown numerically in two problems. Thus, the new codes provide very good results compared to other well-known ODE solvers. Finally, a new strategy is proposed to increase the efficiency of these schemes, and it is discussed the idea of combining ESERK families in one code, because typically, stiff problems have different zones and according to them and the requested tolerance the optimum order of convergence is different.}, language = {en} } @inproceedings{SimsekKrauseEngelmann2024, author = {Simsek, Beril and Krause, Hans-Joachim and Engelmann, Ulrich M.}, title = {Magnetic biosensing with magnetic nanoparticles: Simulative approach to predict signal intensity in frequency mixing magnetic detection}, series = {YRA MedTech Symposium (2024)}, booktitle = {YRA MedTech Symposium (2024)}, editor = {Digel, Ilya and Staat, Manfred and Trzewik, J{\"u}rgen and Sielemann, Stefanie and Erni, Daniel and Zylka, Waldemar}, publisher = {Universit{\"a}t Duisburg-Essen}, address = {Duisburg}, organization = {MedTech Symposium}, isbn = {978-3-940402-65-3}, doi = {10.17185/duepublico/81475}, pages = {27 -- 28}, year = {2024}, abstract = {Magnetic nanoparticles (MNP) are investigated with great interest for biomedical applications in diagnostics (e.g. imaging: magnetic particle imaging (MPI)), therapeutics (e.g. hyperthermia: magnetic fluid hyperthermia (MFH)) and multi-purpose biosensing (e.g. magnetic immunoassays (MIA)). What all of these applications have in common is that they are based on the unique magnetic relaxation mechanisms of MNP in an alternating magnetic field (AMF). While MFH and MPI are currently the most prominent examples of biomedical applications, here we present results on the relatively new biosensing application of frequency mixing magnetic detection (FMMD) from a simulation perspective. In general, we ask how the key parameters of MNP (core size and magnetic anisotropy) affect the FMMD signal: by varying the core size, we investigate the effect of the magnetic volume per MNP; and by changing the effective magnetic anisotropy, we study the MNPs' flexibility to leave its preferred magnetization direction. From this, we predict the most effective combination of MNP core size and magnetic anisotropy for maximum signal generation.}, language = {en} } @article{RhodenBallGrajewskietal.2023, author = {Rhoden, Imke and Ball, Christopher Stephen and Grajewski, Matthias and Kuckshinrich, Wilhelm}, title = {Reverse engineering of stakeholder preferences - A multi-criteria assessment of the German passenger car sector}, series = {Renewable and Sustainable Energy Reviews}, volume = {181}, journal = {Renewable and Sustainable Energy Reviews}, number = {July 2023}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1364-0321}, doi = {10.1016/j.rser.2023.113352}, pages = {Article number: 113352}, year = {2023}, abstract = {Germany is a frontrunner in setting frameworks for the transition to a low-carbon system. The mobility sector plays a significant role in this shift, affecting different people and groups on multiple levels. Without acceptance from these stakeholders, emission targets are out of reach. This research analyzes how the heterogeneous preferences of various stakeholders align with the transformation of the mobility sector, looking at the extent to which the German transformation paths are supported and where stakeholders are located. Under the research objective of comparing stakeholders' preferences to identify which car segments require additional support for a successful climate transition, a status quo of stakeholders and car performance criteria is the foundation for the analysis. Stakeholders' hidden preferences hinder the derivation of criteria weightings from stakeholders; therefore, a ranking from observed preferences is used. This study's inverse multi-criteria decision analysis means that weightings can be predicted and used together with a recalibrated performance matrix to explore future preferences toward car segments. Results show that stakeholders prefer medium-sized cars, with the trend pointing towards the increased potential for alternative propulsion technologies and electrified vehicles. These insights can guide the improved targeting of policy supporting the energy and mobility transformation. Additionally, the method proposed in this work can fully handle subjective approaches while incorporating a priori information. A software implementation of the proposed method completes this work and is made publicly available.}, language = {en} } @article{KleefeldZimmermann2022, author = {Kleefeld, Andreas and Zimmermann, M.}, title = {Computing Elastic Interior Transmission Eigenvalues}, series = {Integral Methods in Science and Engineering}, journal = {Integral Methods in Science and Engineering}, editor = {Constanda, Christian and Bodmann, Bardo E.J. and Harris, Paul J.}, publisher = {Birkh{\"a}user}, address = {Cham}, isbn = {978-3-031-07171-3}, doi = {10.1007/978-3-031-07171-3_10}, pages = {139 -- 155}, year = {2022}, abstract = {An alternative method is presented to numerically compute interior elastic transmission eigenvalues for various domains in two dimensions. This is achieved by discretizing the resulting system of boundary integral equations in combination with a nonlinear eigenvalue solver. Numerical results are given to show that this new approach can provide better results than the finite element method when dealing with general domains.}, language = {en} } @book{Laack2022, author = {Laack, Walter van}, title = {Schnittstelle Tod: Was lernen wir durch Corona {\"u}ber Leben und Tod?}, publisher = {van Laack GmbH}, address = {Aachen}, isbn = {978-3-936624-53-3}, pages = {108 Seiten}, year = {2022}, language = {de} } @article{RoethenbacherCesariDoppleretal.2022, author = {R{\"o}thenbacher, Annika and Cesari, Matteo and Doppler, Christopher E.J. and Okkels, Niels and Willemsen, Nele and Sembowski, Nora and Seger, Aline and Lindner, Marie and Brune, Corinna and Stefani, Ambra and H{\"o}gl, Birgit and Bialonski, Stephan and Borghammer, Per and Fink, Gereon R. and Schober, Martin and Sommerauer, Michael}, title = {RBDtector: an open-source software to detect REM sleep without atonia according to visual scoring criteria}, series = {Scientific Reports}, volume = {12}, journal = {Scientific Reports}, number = {Article number: 20886}, publisher = {Springer Nature}, address = {London}, issn = {2045-2322}, doi = {10.1038/s41598-022-25163-9}, pages = {1 -- 14}, year = {2022}, abstract = {REM sleep without atonia (RSWA) is a key feature for the diagnosis of rapid eye movement (REM) sleep behaviour disorder (RBD). We introduce RBDtector, a novel open-source software to score RSWA according to established SINBAR visual scoring criteria. We assessed muscle activity of the mentalis, flexor digitorum superficialis (FDS), and anterior tibialis (AT) muscles. RSWA was scored manually as tonic, phasic, and any activity by human scorers as well as using RBDtector in 20 subjects. Subsequently, 174 subjects (72 without RBD and 102 with RBD) were analysed with RBDtector to show the algorithm's applicability. We additionally compared RBDtector estimates to a previously published dataset. RBDtector showed robust conformity with human scorings. The highest congruency was achieved for phasic and any activity of the FDS. Combining mentalis any and FDS any, RBDtector identified RBD subjects with 100\% specificity and 96\% sensitivity applying a cut-off of 20.6\%. Comparable performance was obtained without manual artefact removal. RBD subjects also showed muscle bouts of higher amplitude and longer duration. RBDtector provides estimates of tonic, phasic, and any activity comparable to human scorings. RBDtector, which is freely available, can help identify RBD subjects and provides reliable RSWA metrics.}, language = {en} } @incollection{EngelmannBaumann2023, author = {Engelmann, Ulrich M. and Baumann, Martin}, title = {Moderationsexpertise f{\"u}r QMBs - die Methoden}, series = {Qualit{\"a}tsmanagement im Gesundheitswesen}, booktitle = {Qualit{\"a}tsmanagement im Gesundheitswesen}, editor = {Herbig, Nicola and Poppelreuter, Stefan}, edition = {60. Update}, publisher = {T{\"U}V-Verlag}, address = {K{\"o}ln}, isbn = {978-3-8249-0714-4}, pages = {Kapitel 10815}, year = {2023}, abstract = {Damit Sie als Moderator effektiv und professionell moderieren k{\"o}nnen, sollten Sie die entsprechenden Methoden kennen. Mit den richtigen Methoden k{\"o}nnen Sie Diskussionen leiten, Konflikte l{\"o}sen, die Teilnehmer motivieren und daf{\"u}r sorgen, dass die Ziele der Veranstaltung erreicht werden. Außerdem helfen sie Ihnen, eine positive Atmosph{\"a}re zu schaffen und das Interesse der Teilnehmer zu halten. In diesem zweiten Beitrag der mehrteiligen Serie lernen Sie die grunds{\"a}tzlichen Methoden kennen, um erfolgreiche Teamsitzungen, Arbeitsgruppentreffen, Kick-offs und Meetings durchzuf{\"u}hren.}, language = {de} } @article{Gaigall2020, author = {Gaigall, Daniel}, title = {Rothman-Woodroofe symmetry test statistic revisited}, series = {Computational Statistics \& Data Analysis}, volume = {2020}, journal = {Computational Statistics \& Data Analysis}, number = {142}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0167-9473}, doi = {10.1016/j.csda.2019.106837}, pages = {Artikel 106837}, year = {2020}, abstract = {The Rothman-Woodroofe symmetry test statistic is revisited on the basis of independent but not necessarily identically distributed random variables. The distribution-freeness if the underlying distributions are all symmetric and continuous is obtained. The results are applied for testing symmetry in a meta-analysis random effects model. The consistency of the procedure is discussed in this situation as well. A comparison with an alternative proposal from the literature is conducted via simulations. Real data are analyzed to demonstrate how the new approach works in practice.}, language = {en} } @article{UysalFiratCreutzetal.2022, author = {Uysal, Karya and Firat, Ipek Serat and Creutz, Till and Aydin, Inci Cansu and Artmann, Gerhard and Teusch, Nicole and Temiz Artmann, Ayseg{\"u}l}, title = {A novel in vitro wound healing assay using free-standing, ultra-thin PDMS membranes}, series = {membranes}, volume = {2023}, journal = {membranes}, number = {13(1)}, publisher = {MDPI}, address = {Basel}, doi = {10.3390/membranes13010022}, pages = {Artikel 22}, year = {2022}, abstract = {Advances in polymer science have significantly increased polymer applications in life sciences. We report the use of free-standing, ultra-thin polydimethylsiloxane (PDMS) membranes, called CellDrum, as cell culture substrates for an in vitro wound model. Dermal fibroblast monolayers from 28- and 88-year-old donors were cultured on CellDrums. By using stainless steel balls, circular cell-free areas were created in the cell layer (wounding). Sinusoidal strain of 1 Hz, 5\% strain, was applied to membranes for 30 min in 4 sessions. The gap circumference and closure rate of un-stretched samples (controls) and stretched samples were monitored over 4 days to investigate the effects of donor age and mechanical strain on wound closure. A significant decrease in gap circumference and an increase in gap closure rate were observed in trained samples from younger donors and control samples from older donors. In contrast, a significant decrease in gap closure rate and an increase in wound circumference were observed in the trained samples from older donors. Through these results, we propose the model of a cell monolayer on stretchable CellDrums as a practical tool for wound healing research. The combination of biomechanical cell loading in conjunction with analyses such as gene/protein expression seems promising beyond the scope published here.}, language = {en} } @inproceedings{deHondePorstDigel2017, author = {de Honde, Lukas and Porst, Dariusz and Digel, Ilya}, title = {A randomized, observational thermographic study of the neck region before and after a physiotherapeutic intervention}, series = {2nd YRA MedTech Symposium 2017 : June 8th - 9th / 2017 / Hochschule Ruhr-West}, booktitle = {2nd YRA MedTech Symposium 2017 : June 8th - 9th / 2017 / Hochschule Ruhr-West}, editor = {Fischerauer, Alice}, publisher = {Universit{\"a}t Duisburg-Essen}, address = {Duisburg}, organization = {MedTech Symposium}, isbn = {978-3-9814801-9-1}, doi = {10.17185/duepublico/43984}, pages = {122 -- 123}, year = {2017}, language = {en} } @article{AyalaHarrisKleefeld2024, author = {Ayala, Rafael Ceja and Harris, Isaac and Kleefeld, Andreas}, title = {Direct sampling method via Landweber iteration for an absorbing scatterer with a conductive boundary}, series = {Inverse Problems and Imaging}, volume = {18}, journal = {Inverse Problems and Imaging}, number = {3}, publisher = {AIMS}, address = {Springfield}, issn = {1930-8337}, doi = {10.3934/ipi.2023051}, pages = {708 -- 729}, year = {2024}, abstract = {In this paper, we consider the inverse shape problem of recovering isotropic scatterers with a conductive boundary condition. Here, we assume that the measured far-field data is known at a fixed wave number. Motivated by recent work, we study a new direct sampling indicator based on the Landweber iteration and the factorization method. Therefore, we prove the connection between these reconstruction methods. The method studied here falls under the category of qualitative reconstruction methods where an imaging function is used to recover the absorbing scatterer. We prove stability of our new imaging function as well as derive a discrepancy principle for recovering the regularization parameter. The theoretical results are verified with numerical examples to show how the reconstruction performs by the new Landweber direct sampling method.}, language = {en} } @article{FrotscherMuanghongDursunetal.2016, author = {Frotscher, Ralf and Muanghong, Danita and Dursun, G{\"o}zde and Goßmann, Matthias and Temiz Artmann, Ayseg{\"u}l and Staat, Manfred}, title = {Sample-specific adaption of an improved electro-mechanical model of in vitro cardiac tissue}, series = {Journal of Biomechanics}, volume = {49}, journal = {Journal of Biomechanics}, number = {12}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0021-9290 (Print)}, doi = {10.1016/j.jbiomech.2016.01.039}, pages = {2428 -- 2435}, year = {2016}, abstract = {We present an electromechanically coupled computational model for the investigation of a thin cardiac tissue construct consisting of human-induced pluripotent stem cell-derived atrial, ventricular and sinoatrial cardiomyocytes. The mechanical and electrophysiological parts of the finite element model, as well as their coupling are explained in detail. The model is implemented in the open source finite element code Code_Aster and is employed for the simulation of a thin circular membrane deflected by a monolayer of autonomously beating, circular, thin cardiac tissue. Two cardio-active drugs, S-Bay K8644 and veratridine, are applied in experiments and simulations and are investigated with respect to their chronotropic effects on the tissue. These results demonstrate the potential of coupled micro- and macroscopic electromechanical models of cardiac tissue to be adapted to experimental results at the cellular level. Further model improvements are discussed taking into account experimentally measurable quantities that can easily be extracted from the obtained experimental results. The goal is to estimate the potential to adapt the presented model to sample specific cell cultures.}, language = {en} } @article{LeschingerBirgelHackletal.2019, author = {Leschinger, Tim and Birgel, Stefan and Hackl, Michael and Staat, Manfred and M{\"u}ller, Lars Peter and Wegmann, Kilian}, title = {A musculoskeletal shoulder simulation of moment arms and joint reaction forces after medialization of the supraspinatus footprint in rotator cuff repair}, series = {Computer Methods in Biomechanics and Biomedical Engineering}, journal = {Computer Methods in Biomechanics and Biomedical Engineering}, number = {Early view}, publisher = {Taylor \& Francis}, address = {London}, doi = {10.1080/10255842.2019.1572749}, year = {2019}, language = {en} } @article{DietzelWeberPorschenetal.1976, author = {Dietzel, F. and Weber, Hans-Joachim and Porschen, W. and Feinendegen, L. E.}, title = {Zur W{\"a}rmeempfindlichkeit von oxischen und hypoxischen Zellen in einem Tumor}, series = {Naturwissenschaften}, volume = {63}, journal = {Naturwissenschaften}, number = {12}, publisher = {Springer}, address = {Heidelberg}, issn = {0028-1042}, doi = {10.1007/BF00622808}, pages = {585 -- 586}, year = {1976}, language = {de} } @book{Laack2022, author = {Laack, Walter van}, title = {Aufruf zum Nachdenken: Corona und neue Kriege - Wie kann die Menschheit {\"u}berleben?}, publisher = {van Laack GmbH}, address = {Aachen}, isbn = {978-3-936624-56-4}, pages = {56 Seiten}, year = {2022}, language = {de} } @article{HarrisKleefeld2018, author = {Harris, Isaac and Kleefeld, Andreas}, title = {The inverse scattering problem for a conductive boundary condition and transmission eigenvalues}, series = {Applicable Analysis}, volume = {99}, journal = {Applicable Analysis}, number = {3}, publisher = {Taylor \& Francis}, address = {London}, issn = {1563-504X}, doi = {10.1080/00036811.2018.1504028}, pages = {508 -- 529}, year = {2018}, abstract = {In this paper, we consider the inverse scattering problem associated with an inhomogeneous media with a conductive boundary. In particular, we are interested in two problems that arise from this inverse problem: the inverse conductivity problem and the corresponding interior transmission eigenvalue problem. The inverse conductivity problem is to recover the conductive boundary parameter from the measured scattering data. We prove that the measured scatted data uniquely determine the conductivity parameter as well as describe a direct algorithm to recover the conductivity. The interior transmission eigenvalue problem is an eigenvalue problem associated with the inverse scattering of such materials. We investigate the convergence of the eigenvalues as the conductivity parameter tends to zero as well as prove existence and discreteness for the case of an absorbing media. Lastly, several numerical and analytical results support the theory and we show that the inside-outside duality method can be used to reconstruct the interior conductive eigenvalues.}, language = {en} } @inproceedings{AbelPerezVianaCiritsisetal.2017, author = {Abel, Alexander and P{\´e}rez-Viana, Daniel and Ciritsis, Bernard and Staat, Manfred}, title = {Prevention of femur neck fractures through femoroplasty}, series = {2nd YRA MedTech Symposium 2017 : June 8th - 9th / 2017 / Hochschule Ruhr-West}, booktitle = {2nd YRA MedTech Symposium 2017 : June 8th - 9th / 2017 / Hochschule Ruhr-West}, editor = {Erni, Daniel and Fischerauer, Alice and Himmel, J{\"o}rg and Seeger, Thomas and Thelen, Klaus}, publisher = {Universit{\"a}t Duisburg-Essen}, address = {Duisburg}, organization = {MedTech Symposium}, isbn = {978-3-9814801-9-1}, doi = {10.17185/duepublico/43984}, pages = {114 -- 115}, year = {2017}, language = {en} } @article{Gaigall2021, author = {Gaigall, Daniel}, title = {Test for Changes in the Modeled Solvency Capital Requirement of an Internal Risk Model}, series = {ASTIN Bulletin}, volume = {51}, journal = {ASTIN Bulletin}, number = {3}, publisher = {Cambridge Univ. Press}, address = {Cambridge}, issn = {1783-1350}, doi = {10.1017/asb.2021.20}, pages = {813 -- 837}, year = {2021}, abstract = {In the context of the Solvency II directive, the operation of an internal risk model is a possible way for risk assessment and for the determination of the solvency capital requirement of an insurance company in the European Union. A Monte Carlo procedure is customary to generate a model output. To be compliant with the directive, validation of the internal risk model is conducted on the basis of the model output. For this purpose, we suggest a new test for checking whether there is a significant change in the modeled solvency capital requirement. Asymptotic properties of the test statistic are investigated and a bootstrap approximation is justified. A simulation study investigates the performance of the test in the finite sample case and confirms the theoretical results. The internal risk model and the application of the test is illustrated in a simplified example. The method has more general usage for inference of a broad class of law-invariant and coherent risk measures on the basis of a paired sample.}, language = {en} } @book{Laack2019, author = {Laack, Walter van}, title = {Weltbilder gestern und heute - Was bleibt und wor{\"u}ber lacht man morgen?}, series = {Vortr{\"a}ge \& Einsichten, Lectures \& Insights}, journal = {Vortr{\"a}ge \& Einsichten, Lectures \& Insights}, number = {Band 2}, publisher = {van Laack Buchverlag}, address = {Aachen}, isbn = {ISBN 978-3936624-44-1}, pages = {56 Seiten}, year = {2019}, language = {de} } @incollection{EngelmannBaumann2023, author = {Engelmann, Ulrich M. and Baumann, Martin}, title = {Moderationsexpertise f{\"u}r QMBs - die Methoden}, series = {Qualit{\"a}tsmanagement in Dienstleistungsunternehmen}, booktitle = {Qualit{\"a}tsmanagement in Dienstleistungsunternehmen}, editor = {Thomann, Hermann and Tr{\"a}ger, Thomas}, publisher = {T{\"U}V-Verlag}, address = {K{\"o}ln}, isbn = {978-3-8249-0473-0}, pages = {Kapitel 08631}, year = {2023}, abstract = {Damit Sie als Moderator effektiv und professionell moderieren k{\"o}nnen, sollten Sie die entsprechenden Methoden kennen. Mit den richtigen Methoden k{\"o}nnen Sie Diskussionen leiten, Konflikte l{\"o}sen, die Teilnehmer motivieren und daf{\"u}r sorgen, dass die Ziele der Veranstaltung erreicht werden. Außerdem helfen sie Ihnen, eine positive Atmosph{\"a}re zu schaffen und das Interesse der Teilnehmer zu halten. In diesem zweiten Beitrag der mehrteiligen Serie lernen Sie die grunds{\"a}tzlichen Methoden kennen, um erfolgreiche Teamsitzungen, Arbeitsgruppentreffen, Kick-offs und Meetings durchzuf{\"u}hren.}, language = {de} } @article{BaringhausGaigallThiele2018, author = {Baringhaus, Ludwig and Gaigall, Daniel and Thiele, Jan Philipp}, title = {Statistical inference for L²-distances to uniformity}, series = {Computational Statistics}, volume = {2018}, journal = {Computational Statistics}, number = {33}, publisher = {Springer}, address = {Berlin}, issn = {1613-9658}, doi = {10.1007/s00180-018-0820-0}, pages = {1863 -- 1896}, year = {2018}, abstract = {The paper deals with the asymptotic behaviour of estimators, statistical tests and confidence intervals for L²-distances to uniformity based on the empirical distribution function, the integrated empirical distribution function and the integrated empirical survival function. Approximations of power functions, confidence intervals for the L²-distances and statistical neighbourhood-of-uniformity validation tests are obtained as main applications. The finite sample behaviour of the procedures is illustrated by a simulation study.}, language = {en} } @article{SchoeningBronderWuetal.2017, author = {Sch{\"o}ning, Michael Josef and Bronder, Thomas and Wu, Chunsheng and Scheja, Sabrina and Jessing, Max and Metzger-Boddien, Christoph and Keusgen, Michael and Poghossian, Arshak}, title = {Label-Free DNA Detection with Capacitive Field-Effect Devices—Challenges and Opportunities}, series = {Proceedings}, volume = {1}, journal = {Proceedings}, number = {8}, publisher = {MDPI}, address = {Basel}, issn = {2504-3900}, doi = {10.3390/proceedings1080719}, pages = {Artikel 719}, year = {2017}, abstract = {Field-effect EIS (electrolyte-insulator-semiconductor) sensors modified with a positively charged weak polyelectrolyte layer have been applied for the electrical detection of DNA (deoxyribonucleic acid) immobilization and hybridization by the intrinsic molecular charge. The EIS sensors are able to detect the existence of target DNA amplicons in PCR (polymerase chain reaction) samples and thus, can be used as tool for a quick verification of DNA amplification and the successful PCR process. Due to their miniaturized setup, compatibility with advanced micro- and nanotechnologies, and ability to detect biomolecules by their intrinsic molecular charge, those sensors can serve as possible platform for the development of label-free DNA chips. Possible application fields as well as challenges and limitations will be discussed.}, language = {en} } @article{Gaigall2020, author = {Gaigall, Daniel}, title = {Testing marginal homogeneity of a continuous bivariate distribution with possibly incomplete paired data}, series = {Metrika}, volume = {2020}, journal = {Metrika}, number = {83}, publisher = {Springer}, issn = {1435-926X}, doi = {10.1007/s00184-019-00742-5}, pages = {437 -- 465}, year = {2020}, abstract = {We discuss the testing problem of homogeneity of the marginal distributions of a continuous bivariate distribution based on a paired sample with possibly missing components (missing completely at random). Applying the well-known two-sample Cr{\´a}mer-von-Mises distance to the remaining data, we determine the limiting null distribution of our test statistic in this situation. It is seen that a new resampling approach is appropriate for the approximation of the unknown null distribution. We prove that the resulting test asymptotically reaches the significance level and is consistent. Properties of the test under local alternatives are pointed out as well. Simulations investigate the quality of the approximation and the power of the new approach in the finite sample case. As an illustration we apply the test to real data sets.}, language = {en} } @article{RichterBraunsteinWinnardetal.2017, author = {Richter, Charlotte and Braunstein, Bjoern and Winnard, Andrew and Nasser, Mona and Weber, T.}, title = {Human Biomechanical and Cardiopulmonary Responses to Partial Gravity - A Systematic Review}, series = {Frontiers in physiology}, journal = {Frontiers in physiology}, number = {8, article 583}, doi = {10.3389/fphys.2017.00583}, pages = {22 Seiten}, year = {2017}, language = {en} } @inproceedings{HunkerJungGossmannetal.2019, author = {Hunker, Jan and Jung, Alexander and Goßmann, Matthias and Linder, Peter and Staat, Manfred}, title = {Development of a tool to analyze the conduction speed in microelectrode array measurements of cardiac tissue}, series = {3rd YRA MedTech Symposium 2019 : May 24 / 2019 / FH Aachen}, booktitle = {3rd YRA MedTech Symposium 2019 : May 24 / 2019 / FH Aachen}, editor = {Staat, Manfred and Erni, Daniel}, publisher = {Universit{\"a}t Duisburg-Essen}, address = {Duisburg}, organization = {MedTech Symposium}, isbn = {978-3-940402-22-6}, doi = {10.17185/duepublico/48750}, pages = {7 -- 8}, year = {2019}, abstract = {The discovery of human induced pluripotent stem cells reprogrammed from somatic cells [1] and their ability to differentiate into cardiomyocytes (hiPSC-CMs) has provided a robust platform for drug screening [2]. Drug screenings are essential in the development of new components, particularly for evaluating the potential of drugs to induce life-threatening pro-arrhythmias. Between 1988 and 2009, 14 drugs have been removed from the market for this reason [3]. The microelectrode array (MEA) technique is a robust tool for drug screening as it detects the field potentials (FPs) for the entire cell culture. Furthermore, the propagation of the field potential can be examined on an electrode basis. To analyze MEA measurements in detail, we have developed an open-source tool.}, language = {en} } @inproceedings{JungStaatMueller2016, author = {Jung, Alexander and Staat, Manfred and M{\"u}ller, Wolfram}, title = {Effect of wind on flight style optimisation in ski jumping}, series = {15th International Symposium on Computer Simulation in Biomechanics ; July 9th-11th 2015, Edinburgh, UK}, booktitle = {15th International Symposium on Computer Simulation in Biomechanics ; July 9th-11th 2015, Edinburgh, UK}, publisher = {The University of Edinburgh ; Loughborough University}, address = {Edinburgh}, pages = {53 -- 54}, year = {2016}, language = {en} } @article{Gaigall2019, author = {Gaigall, Daniel}, title = {On a new approach to the multi-sample goodness-of-fit problem}, series = {Communications in Statistics - Simulation and Computation}, volume = {53}, journal = {Communications in Statistics - Simulation and Computation}, number = {10}, publisher = {Taylor \& Francis}, address = {London}, issn = {1532-4141}, doi = {10.1080/03610918.2019.1618472}, pages = {2971 -- 2989}, year = {2019}, abstract = {Suppose we have k samples X₁,₁,…,X₁,ₙ₁,…,Xₖ,₁,…,Xₖ,ₙₖ with different sample sizes ₙ₁,…,ₙₖ and unknown underlying distribution functions F₁,…,Fₖ as observations plus k families of distribution functions {G₁(⋅,ϑ);ϑ∈Θ},…,{Gₖ(⋅,ϑ);ϑ∈Θ}, each indexed by elements ϑ from the same parameter set Θ, we consider the new goodness-of-fit problem whether or not (F₁,…,Fₖ) belongs to the parametric family {(G₁(⋅,ϑ),…,Gₖ(⋅,ϑ));ϑ∈Θ}. New test statistics are presented and a parametric bootstrap procedure for the approximation of the unknown null distributions is discussed. Under regularity assumptions, it is proved that the approximation works asymptotically, and the limiting distributions of the test statistics in the null hypothesis case are determined. Simulation studies investigate the quality of the new approach for small and moderate sample sizes. Applications to real-data sets illustrate how the idea can be used for verifying model assumptions.}, language = {en} } @unpublished{GriegerMehrkanoonBialonski2024, author = {Grieger, Niklas and Mehrkanoon, Siamak and Bialonski, Stephan}, title = {Preprint: Data-efficient sleep staging with synthetic time series pretraining}, series = {arXiv}, journal = {arXiv}, pages = {10 Seiten}, year = {2024}, abstract = {Analyzing electroencephalographic (EEG) time series can be challenging, especially with deep neural networks, due to the large variability among human subjects and often small datasets. To address these challenges, various strategies, such as self-supervised learning, have been suggested, but they typically rely on extensive empirical datasets. Inspired by recent advances in computer vision, we propose a pretraining task termed "frequency pretraining" to pretrain a neural network for sleep staging by predicting the frequency content of randomly generated synthetic time series. Our experiments demonstrate that our method surpasses fully supervised learning in scenarios with limited data and few subjects, and matches its performance in regimes with many subjects. Furthermore, our results underline the relevance of frequency information for sleep stage scoring, while also demonstrating that deep neural networks utilize information beyond frequencies to enhance sleep staging performance, which is consistent with previous research. We anticipate that our approach will be advantageous across a broad spectrum of applications where EEG data is limited or derived from a small number of subjects, including the domain of brain-computer interfaces.}, language = {en} } @article{Laack2013, author = {Laack, Walter van}, title = {Our world is well ordered in measurement and number : or why natural constants are as they are}, series = {American Journal of Humanities and Social Sciences (AHSS)}, volume = {1}, journal = {American Journal of Humanities and Social Sciences (AHSS)}, number = {4}, issn = {2329-079X}, doi = {10.11634/232907811301390}, pages = {219 -- 221}, year = {2013}, abstract = {All the important natural constants can be logically explained with and derived from the first four ordinal numbers, 1, 2, 3 and 4, its addition to ten and finally the standard values for obviously maximal feasibility Ω and the optimum in our world, the Golden Section (GS), i.e. the number sequences 273 and 618. They both are the first three numbers of irrational results by an arithmetical transformation of simple geometrical relationships by creating multiplicity out of singularity. Both of them show that the infinite is inherent in finiteness and explain in a simple way the smallest deviations and fluctuations between the physical AS-IS state and the obvious spiritual ideal behind: Wherever we look in this world, and especially in important key-positions, we regularly find these sequences. All of the above mentioned numbers so seem to be key players in our world, what can be demonstrated by the derivation of natural constants.}, language = {en} } @incollection{EngelmannShashaSlabu2021, author = {Engelmann, Ulrich M. and Shasha, Carolyn and Slabu, Ioana}, title = {Magnetic nanoparticle relaxation in biomedical application: focus on simulating nanoparticle heating}, series = {Magnetic nanoparticles in human health and medicine}, booktitle = {Magnetic nanoparticles in human health and medicine}, publisher = {Wiley-Blackwell}, address = {Hoboken, New Jeersey}, isbn = {978-1-119-75467-1}, pages = {327 -- 354}, year = {2021}, language = {en} } @article{BronderJessingPoghossianetal.2018, author = {Bronder, Thomas and Jessing, Max P. and Poghossian, Arshak and Keusgen, Michael and Sch{\"o}ning, Michael Josef}, title = {Detection of PCR-Amplified Tuberculosis DNA Fragments with Polyelectrolyte-Modified Field-Effect Sensors}, series = {Analytical Chemistry}, volume = {90}, journal = {Analytical Chemistry}, number = {12}, publisher = {ACS Publications}, address = {Washington, DC}, issn = {0003-2700}, doi = {10.1021/acs.analchem.8b01807}, pages = {7747 -- 7753}, year = {2018}, abstract = {Field-effect-based electrolyte-insulator-semiconductor (EIS) sensors were modified with a bilayer of positively charged weak polyelectrolyte (poly(allylamine hydrochloride) (PAH)) and probe single-stranded DNA (ssDNA) and are used for the detection of complementary single-stranded target DNA (cDNA) in different test solutions. The sensing mechanism is based on the detection of the intrinsic molecular charge of target cDNA molecules after the hybridization event between cDNA and immobilized probe ssDNA. The test solutions contain synthetic cDNA oligonucleotides (with a sequence of tuberculosis mycobacteria genome) or PCR-amplified DNA (which origins from a template DNA strand that has been extracted from Mycobacterium avium paratuberculosis-spiked human sputum samples), respectively. Sensor responses up to 41 mV have been measured for the test solutions with DNA, while only small signals of ∼5 mV were detected for solutions without DNA. The lower detection limit of the EIS sensors was ∼0.3 nM, and the sensitivity was ∼7.2 mV/decade. Fluorescence experiments using SybrGreen I fluorescence dye support the electrochemical results.}, language = {en} } @misc{BurgethKleefeldNaegeletal.2020, author = {Burgeth, Bernhard and Kleefeld, Andreas and Naegel, Beno{\^i}t and Perret, Benjamin}, title = {Editorial — Special Issue: ISMM 2019}, series = {Mathematical Morphology - Theory and Applications}, volume = {4}, journal = {Mathematical Morphology - Theory and Applications}, number = {1}, publisher = {De Gruyter}, address = {Warschau}, issn = {2353-3390}, doi = {10.1515/mathm-2020-0200}, pages = {159 -- 161}, year = {2020}, abstract = {This editorial presents the Special Issue dedicated to the conference ISMM 2019 and summarizes the articles published in this Special Issue.}, language = {en} } @article{DitzhausGaigall2018, author = {Ditzhaus, Marc and Gaigall, Daniel}, title = {A consistent goodness-of-fit test for huge dimensional and functional data}, series = {Journal of Nonparametric Statistics}, volume = {30}, journal = {Journal of Nonparametric Statistics}, number = {4}, publisher = {Taylor \& Francis}, address = {Abingdon}, issn = {1029-0311}, doi = {10.1080/10485252.2018.1486402}, pages = {834 -- 859}, year = {2018}, abstract = {A nonparametric goodness-of-fit test for random variables with values in a separable Hilbert space is investigated. To verify the null hypothesis that the data come from a specific distribution, an integral type test based on a Cram{\´e}r-von-Mises statistic is suggested. The convergence in distribution of the test statistic under the null hypothesis is proved and the test's consistency is concluded. Moreover, properties under local alternatives are discussed. Applications are given for data of huge but finite dimension and for functional data in infinite dimensional spaces. A general approach enables the treatment of incomplete data. In simulation studies the test competes with alternative proposals.}, language = {en} } @incollection{EngelmannBaumann2023, author = {Engelmann, Ulrich M. and Baumann, Martin}, title = {Moderationsexpertise - die Methoden}, series = {IT-Servicemanagement}, booktitle = {IT-Servicemanagement}, editor = {Lindinger, Markus and Bartsch, Oliver}, edition = {54. Update}, publisher = {T{\"U}V-Verlag}, address = {K{\"o}ln}, isbn = {978-3-8249-1154-7}, pages = {Kapitel 05531}, year = {2023}, abstract = {Damit Sie als Moderator effektiv und professionell moderieren k{\"o}nnen, sollten Sie die entsprechenden Methoden kennen. Mit den richtigen Methoden k{\"o}nnen Sie Diskussionen leiten, Konflikte l{\"o}sen, die Teilnehmer motivieren und daf{\"u}r sorgen, dass die Ziele der Veranstaltung erreicht werden. Außerdem helfen sie Ihnen, eine positive Atmosph{\"a}re zu schaffen und das Interesse der Teilnehmer zu halten. In diesem zweiten Beitrag der mehrteiligen Serie lernen Sie die grunds{\"a}tzlichen Methoden kennen, um erfolgreiche Teamsitzungen, Arbeitsgruppentreffen, Kick-offs und Meetings durchzuf{\"u}hren.}, language = {de} } @article{GaigallGerstenbergTrinh2022, author = {Gaigall, Daniel and Gerstenberg, Julian and Trinh, Thi Thu Ha}, title = {Empirical process of concomitants for partly categorial data and applications in statistics}, series = {Bernoulli}, volume = {28}, journal = {Bernoulli}, number = {2}, publisher = {International Statistical Institute}, address = {Den Haag, NL}, issn = {1573-9759}, doi = {10.3150/21-BEJ1367}, pages = {803 -- 829}, year = {2022}, abstract = {On the basis of independent and identically distributed bivariate random vectors, where the components are categorial and continuous variables, respectively, the related concomitants, also called induced order statistic, are considered. The main theoretical result is a functional central limit theorem for the empirical process of the concomitants in a triangular array setting. A natural application is hypothesis testing. An independence test and a two-sample test are investigated in detail. The fairly general setting enables limit results under local alternatives and bootstrap samples. For the comparison with existing tests from the literature simulation studies are conducted. The empirical results obtained confirm the theoretical findings.}, language = {en} } @article{ArtmannGrebeHomrighausenetal.1988, author = {Artmann, Gerhard and Grebe, R. and Homrighausen, A. and Wolff, H. and Teitel, P. and Schmid-Sch{\"o}nbein, H.}, title = {Response of normal and diabetic erythrocytes to membrane deformation by chemical and mechanical forces. Artmann, Gerhard Michael; Grebe, R.; Homrighausen, A.; Wolff, H.; Teitel, P.; Schmid-Sch{\"o}nbein, H.}, series = {12. Jahrestagung der Gesellschaft f{\"u}r Mikrozirkulation}, journal = {12. Jahrestagung der Gesellschaft f{\"u}r Mikrozirkulation}, publisher = {Karger [u.a.]}, address = {Basel [u.a.]}, pages = {196 -- 200}, year = {1988}, language = {en} } @article{JungMuellerStaat2019, author = {Jung, Alexander and M{\"u}ller, Wolfram and Staat, Manfred}, title = {Optimization of the flight technique in ski jumping: the influence of wind}, number = {Early view}, publisher = {Elsevier}, address = {Amsterdam}, doi = {10.1016/j.jbiomech.2019.03.023}, year = {2019}, language = {en} } @inproceedings{AzarDigel2019, author = {Azar, Fouad and Digel, Ilya}, title = {Utilization of fluorescence spectroscopy and neural networks in clinical analysis}, series = {3rd YRA MedTech Symposium 2019 : May 24 / 2019 / FH Aachen}, booktitle = {3rd YRA MedTech Symposium 2019 : May 24 / 2019 / FH Aachen}, editor = {Staat, Manfred and Erni, Daniel}, publisher = {Universit{\"a}t Duisburg-Essen}, address = {Duisburg}, organization = {MedTech Symposium}, isbn = {978-3-940402-22-6}, doi = {10.17185/duepublico/48750}, pages = {40 -- 41}, year = {2019}, abstract = {Fluorescence topography of human urine in combination with learning algorithms can provide a variant pattern recognition method in analytical clinical chemistry and, eventually, diagnosis.}, language = {en} } @inproceedings{BornheimGriegerBialonski2021, author = {Bornheim, Tobias and Grieger, Niklas and Bialonski, Stephan}, title = {FHAC at GermEval 2021: Identifying German toxic, engaging, and fact-claiming comments with ensemble learning}, series = {Proceedings of the GermEval 2021 Workshop on the Identification of Toxic, Engaging, and Fact-Claiming Comments : 17th Conference on Natural Language Processing KONVENS 2021}, booktitle = {Proceedings of the GermEval 2021 Workshop on the Identification of Toxic, Engaging, and Fact-Claiming Comments : 17th Conference on Natural Language Processing KONVENS 2021}, publisher = {Heinrich Heine University}, address = {D{\"u}sseldorf}, doi = {10.48415/2021/fhw5-x128}, pages = {105 -- 111}, year = {2021}, language = {en} } @incollection{EngelmannBaumann2023, author = {Engelmann, Ulrich M. and Baumann, Martin}, title = {Moderationsexpertise - das Mindset}, series = {IT-Servicemanagement}, booktitle = {IT-Servicemanagement}, editor = {Lindinger, Markus and Bartsch, Oliver}, edition = {54. Update}, publisher = {T{\"U}V-Verlag}, address = {K{\"o}ln}, isbn = {978-3-8249-1154-7}, pages = {Kapitel 05530}, year = {2023}, abstract = {Teamsitzungen, Arbeitsgruppentreffen, Kickoffs und Meetings - sie alle werden mit dem Ziel durchgef{\"u}hrt, innerhalb einer vorgegebenen Zeitspanne ein gemeinsames Arbeitsziel zu erreichen. Damit die Zielerreichung auch bei komplexeren Arbeitsauftr{\"a}gen nicht vom Zufall abh{\"a}ngt, empfiehlt es sich, die Leitung des Ablaufs einem Moderator zu {\"u}bertragen. In diesem Beitrag einer dreiteiligen Serie wird beschrieben, {\"u}ber welches Mindset der Moderator verf{\"u}gen sollte, welche grunds{\"a}tzlichen Methoden hilfreich sind und was bei der Onlinemoderation im Besonderen zu beachten ist.}, language = {de} }