@incollection{Goldbach2012, author = {Goldbach, Daniel}, title = {Zuverl{\"a}ssigkeitsanalyse zur Verifikation der Einhaltung von quantitativen Sicherheitsanforderungen.}, series = {Diagnose in mechatronischen Fahrzeugsystemen V : neue Verfahren f{\"u}r Test, Pr{\"u}fung und Diagnose von E/E-Systemen im Kfz ; [anl{\"a}sslich der 6. Tagung "Diagnose in Mechatronischen Fahrzeugsystemen" in Dresden]. Bernard B{\"a}ker ... (Hrsg.)}, booktitle = {Diagnose in mechatronischen Fahrzeugsystemen V : neue Verfahren f{\"u}r Test, Pr{\"u}fung und Diagnose von E/E-Systemen im Kfz ; [anl{\"a}sslich der 6. Tagung "Diagnose in Mechatronischen Fahrzeugsystemen" in Dresden]. Bernard B{\"a}ker ... (Hrsg.)}, publisher = {Expert Verlag}, address = {Renningen}, isbn = {978-3-8169-3149-2}, pages = {116 -- 132}, year = {2012}, language = {de} } @article{BorgmeierBongaertsMeinhardt2012, author = {Borgmeier, Claudia and Bongaerts, Johannes and Meinhardt, Friedhelm}, title = {Genetic analysis of the Bacillus licheniformis degSU operon and the impact of regulatory mutations on protease production}, series = {Journal of biotechnology}, volume = {159}, journal = {Journal of biotechnology}, number = {1-2}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1873-4863 (E-Journal); 0168-1656 (Print)}, doi = {10.1016/j.jbiotec.2012.02.011}, pages = {12 -- 20}, year = {2012}, abstract = {Disruption experiments targeted at the Bacillus licheniformis degSU operon and GFP-reporter analysis provided evidence for promoter activity immediately upstream of degU. pMutin mediated concomitant introduction of the degU32 allele - known to cause hypersecretion in Bacillus subtilis - resulted in a marked increase in protease activity. Application of 5-fluorouracil based counterselection through establishment of a phosphoribosyltransferase deficient Δupp strain eventually facilitated the marker-free introduction of degU32 leading to further protease enhancement achieving levels as for hypersecreting wild strains in which degU was overexpressed. Surprisingly, deletion of rapG - known to interfere with DegU DNA-binding in B. subtilis - did not enhance protease production neither in the wild type nor in the degU32 strain. The combination of degU32 and Δupp counterselection in the type strain is not only equally effective as in hypersecreting wild strains with respect to protease production but furthermore facilitates genetic strain improvement aiming at biological containment and effectiveness of biotechnological processes.}, language = {en} } @inproceedings{FeldmannPyschnyDoeringetal.2012, author = {Feldmann, Markus and Pyschny, D. and D{\"o}ring, Bernd and Kuhnhenne, Markus}, title = {Life cycle assessment of steel constructions}, series = {Life-cycle and sustainability of civil infrastructure systems : proceedings of the Third International Symposium on Life-Cycle Civil Engineering (IALCCE'12) : Vienna, Austria, October 3-6, 2012}, booktitle = {Life-cycle and sustainability of civil infrastructure systems : proceedings of the Third International Symposium on Life-Cycle Civil Engineering (IALCCE'12) : Vienna, Austria, October 3-6, 2012}, publisher = {Taylor and Francis}, address = {Hoboken}, organization = {International Symposium on Life-Cycle Civil Engineering <3, 2012, Wien>}, isbn = {978-0-203-10336-4}, pages = {321}, year = {2012}, language = {en} } @inproceedings{KuhnhenneDoeringPyschnyetal.2012, author = {Kuhnhenne, Markus and D{\"o}ring, Bernd and Pyschny, Dominik and Feldmann, Markus}, title = {Energy efficient sandwich construction}, series = {Proceedings of the VI International Congress on Architectural Envelopes : 20.6. - 22.6.2012, San Sebastian, Spain}, booktitle = {Proceedings of the VI International Congress on Architectural Envelopes : 20.6. - 22.6.2012, San Sebastian, Spain}, publisher = {ICAE}, organization = {International Congress on Architectural Envelopes <6, 2012, San Sebastian>}, pages = {277 -- 285}, year = {2012}, language = {en} } @phdthesis{Kotliar2012, author = {Kotliar, Konstantin}, title = {Pathophysiologische Beurteilung und h{\"a}modynamische Analyse von mikrostrukturellen Ver{\"a}nderungen des retinalen Gef{\"a}ßl{\"a}ngsschnittsprofils}, pages = {328 S.}, year = {2012}, language = {ru} } @misc{OPUS4-5157, title = {TecScan Journal : Elektromobilit{\"a}t 2012-11}, organization = {FH Aachen, University of Applied Sciences}, year = {2012}, subject = {Elektromobilit{\"a}t; Elektrofahrzeug; Energieversorungsnetz; Kraftfahrzeugtechnik}, language = {de} } @misc{OPUS4-5158, title = {TecScan Journal : Elektromobilit{\"a}t 2012-12}, organization = {FH Aachen, University of Applied Sciences}, year = {2012}, subject = {Elektromobilit{\"a}t; Elektrofahrzeug; Energieversorungsnetz; Kraftfahrzeugtechnik}, language = {de} } @article{HoetterFateriGebhardt2012, author = {H{\"o}tter, Jan-Steffen and Fateri, Miranda and Gebhardt, Andreas}, title = {Selective laser melting of metals: desktop machines open up new chances even for small companies}, series = {Advanced materials research}, volume = {622-623}, journal = {Advanced materials research}, publisher = {Trans Tech Publ.}, address = {Baech}, issn = {1662-8985 (E-Journal); 1022-6680 (Print)}, doi = {10.4028/www.scientific.net/AMR.622-623.461}, pages = {461 -- 465}, year = {2012}, abstract = {Additive manufacturing (AM) of metal parts by using Selective Laser Melting (SLM) has become a powerful tool mostly in the area of automotive, aerospace engineering and others. Especially in the field of dentistry, jewelry and related branches that require individualized or even one-of-a-kind products, the direct digital manufacturing process opens up new ways of design and manufacturing. In these fields, mostly small and medium sized businesses (SME) are operating which do not have sufficient human and economic resources to invest in this technology. But to stay competitive, the application of AM can be regarded as a necessity. In this situation a new desktop machine (Realizer SLM 50) was introduced that cost about 1/3 of a shop floor SLM machine and promises small quality parts. To find out whether the machine really is an alternative for SMEs the University of Applied Science, Aachen, Germany, designed, build and optimized typical parts from the dentistry and the jewelry branches using CoCr and silver material, the latter being new with this application. The paper describes the SLM procedure and how to find and optimize the most important parameters. The test is accompanied by digital simulation in order to verify the build parameters and to plan future builds. The procedure is shown as well as the resulting parts made from CoCr and silver material.}, language = {en} } @article{Knueppel2012, author = {Kn{\"u}ppel, Mark}, title = {Außerbilanzielle Korrekturen}, series = {Handbuch der Bilanzierung online}, journal = {Handbuch der Bilanzierung online}, editor = {Federmann, Rudolf and Kußmaul, Heinz and M{\"u}ller, Stefan}, publisher = {Haufe}, address = {Freiburg}, issn = {0172-0392}, pages = {Artikel HI 1380074}, year = {2012}, language = {de} } @book{Waehlisch2012, author = {W{\"a}hlisch, Georg}, title = {Technisches Zeichnen : L{\"o}sungsvorschl{\"a}ge f{\"u}r das Selbststudium. (Berichte aus dem Maschinenbau)}, publisher = {Shaker}, address = {Aachen}, isbn = {978-3-8440-1159-3}, pages = {[138] S. : zahlr. Ill., graph. Darst.}, year = {2012}, language = {de} } @inproceedings{AchenbachGeimerLynenetal.2012, author = {Achenbach, Timm and Geimer, Konstantin and Lynen, Arthur and G{\"o}ttsche, Joachim and Hoffschmidt, Bernhard}, title = {Simulation of thermo-mechanical processes in open volumetric absorber modules}, series = {SolarPaces 2012 : concentrating solar power and chemical energy systems : Sept. 11 - 14 2012, Marrakech, Marokko}, booktitle = {SolarPaces 2012 : concentrating solar power and chemical energy systems : Sept. 11 - 14 2012, Marrakech, Marokko}, pages = {1 -- 8}, year = {2012}, language = {en} } @inproceedings{BungSunMeirelesetal.2012, author = {Bung, Daniel Bernhard and Sun, Q. and Meireles, I. and Matos, J. and Viseu, T.}, title = {USBR type III stilling basin performance for steep stepped spillways}, series = {Hydraulic structures into the 21st century : 4th IAHR International Symposium on Hydraulic Structures : 9.-11.2.2012, Porto}, booktitle = {Hydraulic structures into the 21st century : 4th IAHR International Symposium on Hydraulic Structures : 9.-11.2.2012, Porto}, organization = {International Symposium on Hydraulic Structures <4, 2012, Porto>}, isbn = {978-989-8509-01-7}, pages = {Elektronisch publiziert}, year = {2012}, language = {en} } @inproceedings{OertelBung2012, author = {Oertel, Mario and Bung, Daniel Bernhard}, title = {Characteristics of cross-bar block ramp flows}, series = {Hydraulic structures into the 21st century : 4th IAHR International Symposium on Hydraulic Structures : 9.-11.2.2012, Porto}, booktitle = {Hydraulic structures into the 21st century : 4th IAHR International Symposium on Hydraulic Structures : 9.-11.2.2012, Porto}, organization = {International Symposium on Hydraulic Structures <4, 2012, Porto>}, isbn = {978-989-8509-01-7}, pages = {Elektronisch publiziert}, year = {2012}, language = {en} } @inproceedings{Bung2012, author = {Bung, Daniel Bernhard}, title = {Sensitivity of phase detection techniques in aerated chute flows to hydraulic design parameters}, series = {2nd European IAHR congress : 27. - 29. June 2012, M{\"u}nchen}, booktitle = {2nd European IAHR congress : 27. - 29. June 2012, M{\"u}nchen}, publisher = {Lehrstuhl u. Versuchsanst. f{\"u}r Wasserbau u. Wasserwirtschaft d. TU M{\"u}nchen}, address = {M{\"u}nchen}, organization = {International Association for Hydraulic Engineering and Research}, isbn = {978-3-943683-03-5}, pages = {Artikelkennnummer: B15}, year = {2012}, language = {en} } @inproceedings{SchlurmannBung2012, author = {Schlurmann, Torsten and Bung, Daniel Bernhard}, title = {Experimental investigation of flow-induced radial gate vibrations at Lower Subansiri dam}, series = {Sixth Chinese-German Joint Symposium on Hydraulic and Ocean Engineering : JOINT 2012 : 23.-29.9.2012, Keelung}, booktitle = {Sixth Chinese-German Joint Symposium on Hydraulic and Ocean Engineering : JOINT 2012 : 23.-29.9.2012, Keelung}, organization = {Chinese-German Joint Symposium on Hydraulic and Ocean Engineering <6, 2012, Keelung>}, pages = {7 -- 14}, year = {2012}, language = {en} } @article{BoettcherHaselhuhnJakseetal.2012, author = {Boettcher, Martin and Haselhuhn, Angelika and Jakse, Gerhard and Brehmer, Bernhard and Kirschner-Hermanns, Ruth}, title = {Overactive bladder syndrome: an underestimated long-term problem after treatment of patients with localized prostate cancer?}, series = {BJU international}, volume = {109}, journal = {BJU international}, number = {12}, publisher = {Wiley-Blackwell}, address = {Oxford}, issn = {1365-2176 (E-Journal); 1464-410X (E-Journal); 0007-1331 (Print); 1464-4096 (Print)}, doi = {10.1111/j.1464-410X.2011.10623.x}, pages = {1824 -- 1830}, year = {2012}, abstract = {In this study we observed courses of micturition symptoms and differentiated degrees of symptoms for each point in time while also considering the impact of bothersomeness. Our data show that not only significantly more patients who have undergone BT suffer from OAB than those who have undergone RP, but also that those affected show significantly higher values for severity of OAB symptoms throughout the whole observation period of 36 months. Our data analysis further shows that variability of OAB symptoms as well as fluctuation of severity of OAB symptoms vary to a significantly higher degree after BT than after RP. Looking only at mean figures at a given point in time clearly underestimates the underlying problem. This fact is not reflected in the literature.}, language = {en} } @article{OertelBung2012, author = {Oertel, Mario and Bung, Daniel Bernhard}, title = {Initial stage of two-dimensional dam-break waves: laboratory versus VOF}, series = {Journal of hydraulic research}, volume = {50}, journal = {Journal of hydraulic research}, number = {1}, publisher = {Taylor \& Francis}, address = {London}, issn = {1814-2079 (E-Journal); 0022-1686 (Print)}, doi = {10.1080/00221686.2011.639981}, pages = {89 -- 97}, year = {2012}, abstract = {Since several decades, dam-break waves have been of main research interest. Mathematical approaches have been developed by analytical, physical and numerical models within the past 120 years. During the past 10 years, the number of research investigations has increased due to improved measurement techniques as well as significantly increased computer memories and performances. In this context, the present research deals with the initial stage of two-dimensional dam-break waves by comparing physical and numerical model results as well as analytical approaches. High-speed images and resulting particle image velocimetry calculations are thereby compared with the numerical volume-of-fluid (VOF) method, included in the commercial code FLOW-3D. Wave profiles and drag forces on placed obstacles are analysed in detail. Generally, a good agreement between the laboratory and VOF results is found.}, language = {en} } @article{RibitschHeumannKarletal.2012, author = {Ribitsch, D. and Heumann, S. and Karl, W. and Gerlach, J. and Leber, R. and Birner-Gruenberger, R. and Gruber, K. and Eiteljoerg, I. and Remler, P. and Siegert, Petra and Lange, J. and Maurer, Karl-Heinz and Berg, G. and Guebitz, G. M. and Schwab, H.}, title = {Extracellular serine proteases from Stenotrophomonas maltophilia: Screening, isolation and heterologous expression in E. coli}, series = {Journal of biotechnology}, volume = {157}, journal = {Journal of biotechnology}, number = {1}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1873-4863 (E-Journal); 0168-1656 (Print)}, doi = {10.1016/j.jbiotec.2011.09.025}, pages = {140 -- 147}, year = {2012}, abstract = {A large strain collection comprising antagonistic bacteria was screened for novel detergent proteases. Several strains displayed protease activity on agar plates containing skim milk but were inactive in liquid media. Encapsulation of cells in alginate beads induced protease production. Stenotrophomonas maltophilia emerged as best performer under washing conditions. For identification of wash-active proteases, four extracellular serine proteases called StmPr1, StmPr2, StmPr3 and StmPr4 were cloned. StmPr2 and StmPr4 were sufficiently overexpressed in E. coli. Expression of StmPr1 and StmPr3 resulted in unprocessed, insoluble protein. Truncation of most of the C-terminal domain which has been identified by enzyme modeling succeeded in expression of soluble, active StmPr1 but failed in case of StmPr3. From laundry application tests StmPr2 turned out to be a highly wash-active protease at 45 °C. Specific activity of StmPr2 determined with suc-l-Ala-l-Ala-l-Pro-l-Phe-p-nitroanilide as the substrate was 17 ± 2 U/mg. In addition we determined the kinetic parameters and cleavage preferences of protease StmPr2.}, language = {en} } @article{SchmitzWeber2012, author = {Schmitz, Philipp and Weber, Martin}, title = {Buying and selling behavior of individual investors in option-like securities}, series = {Die Betriebswirtschaft : DBW}, volume = {72}, journal = {Die Betriebswirtschaft : DBW}, number = {5}, publisher = {Sch{\"a}ffer-Poeschel}, address = {Stuttgart}, issn = {0342-7064}, doi = {10.2139/ssrn.2055088}, pages = {409 -- 426}, year = {2012}, abstract = {We analyze the trading behavior of individual investors in option-like securities, namely bankissued warrants, and thus expand the growing literature of investors behavior to a new kind of securities. A unique data set from a large German discount broker gives us the opportunity to analyze the trading behavior of 1,454 investors, making 89,958 transactions in 6,724 warrants on 397 underlyings. In different logit regression, we make use of the facts that investors can speculate on rising and falling prices of the underlying with call and put warrants and that we also have information about the stock portfolios of the investors. We report several facts about the trading behavior of individual investors in warrants that are consistent with the literature on the behavior of individual investors in the stock market. The warrant investors buy calls and sell puts if the price of the underlying has decreased over the past trading days and they sell calls and buy puts if the price of the underlying has increased. That means, the investors follow negative feedback trading strategies in all four trading categories observed. In addition, we find strong evidence for the disposition effect for call as well as put warrants, which is reversed in December. The trading behavior is also influenced if the underlying reaches some exceptionally prices, e.g. highs, lows or the strike price. We show that hedging, as one natural candidate to buy puts, does not play an important role in the market for bank-issued warrants.}, language = {en} } @article{SchoeningBiselliSelmeretal.2012, author = {Sch{\"o}ning, Michael Josef and Biselli, Manfred and Selmer, Thorsten and {\"O}hlschl{\"a}ger, Peter and Baumann, Marcus and F{\"o}rster, Arnold and Poghossian, Arshak}, title = {Forschung „zwischen" den Disziplinen: das Institut f{\"u}r Nano- und Biotechnologien}, series = {Analytik news : das Online-Labormagazin f{\"u}r Labor und Analytik}, volume = {Publ. online}, journal = {Analytik news : das Online-Labormagazin f{\"u}r Labor und Analytik}, publisher = {Dr. Beyer Internet-Beratung}, address = {Ober-Ramstadt}, pages = {11 Seiten}, year = {2012}, abstract = {"Biologie trifft Mikroelektronik", das Motto des Instituts f{\"u}r Nano- und Biotechnologien (INB) an der FH Aachen, unterstreicht die zunehmende Bedeutung interdisziplin{\"a}r gepr{\"a}gter Forschungsaktivit{\"a}ten. Der thematische Zusammenschluss grundst{\"a}ndiger Disziplinen, wie die Physik, Elektrotechnik, Chemie, Biologie sowie die Materialwissenschaften, l{\"a}sst neue Forschungsgebiete entstehen, ein herausragendes Beispiel hierf{\"u}r ist die Nanotechnologie: Hier werden neue Werkstoffe und Materialien entwickelt, einzelne Nanopartikel oder Molek{\"u}le und deren Wechselwirkung untersucht oder Schichtstrukturen im Nanometerbereich aufgebaut, die neue und vorher nicht bekannte Eigenschaften hervorbringen. Vor diesem Hintergrund b{\"u}ndelt das im Jahre 2006 gegr{\"u}ndete INB die an der FH Aachen vorhandenen Kompetenzen von derzeit insgesamt sieben Laboratorien auf den Gebieten der Halbleitertechnik und Nanoelektronik, Nanostrukturen und DNA-Sensorik, der Chemo- und Biosensorik, der Enzymtechnologie, der Mikrobiologie und Pflanzenbiotechnologie, der Zellkulturtechnik, sowie der Roten Biotechnologie synergetisch. In der Nano- und Biotechnologie steckt außergew{\"o}hnliches Potenzial! Nicht zuletzt deshalb stellen sich die Forscher der Herausforderung, in diesem Bereich gemeinsam zu forschen und Schnittstellen zu nutzen, um so bei der Gestaltung neuartiger Ideen und Produkte mitzuwirken, die zuk{\"u}nftig unser allt{\"a}gliches Leben ver{\"a}ndern werden. Im Folgenden werden die verschiedenen Forschungsbereiche kurz zusammenfassend vorgestellt und vorhandene Interaktionen anhand von exemplarisch ausgew{\"a}hlten, aktuellen Forschungsprojekten skizziert.}, language = {de} } @techreport{SchoeningSelmerBaumann2012, author = {Sch{\"o}ning, Michael Josef and Selmer, Thorsten and Baumann, Marcus}, title = {Schlussbericht zum Projekt "Bio-LAPS" : Optimierung des Betriebs eines Biogasfermenters mit Hilfe eines Feldeffekt-Biosensors auf Basis eines lichtadressierbaren potentiometrischen Sensors (LAPS) : Laufzeit: 01.09.2008 bis 31.01.2012 : F{\"o}rderkennzeichen 07NR264 bzw.22026407}, publisher = {BMELV}, address = {Berlin}, pages = {44 S.}, year = {2012}, language = {de} } @misc{SiegertMerkelHellmuthetal.2012, author = {Siegert, Petra and Merkel, Marion and Hellmuth, Hendrik and O'Connell, Timothy and Maurer, Karl-Heinz}, title = {Stabilisierte fl{\"u}ssige enzymhaltige Tensidzubereitung (Einsatz einer das hydrolytische Enzym stabilisierende Komponente, die ein Monosaccharidglycerat umfasst) [Offenlegungsschrift]}, publisher = {Deutsches Patent- und Markenamt / Europ{\"a}isches Patentamt / WIPO}, address = {M{\"u}nchen / Den Hague / Genf}, pages = {1 -- 17}, year = {2012}, language = {de} } @misc{SiegertSchwanebergMartinezMoyaetal.2012, author = {Siegert, Petra and Schwaneberg, Ulrich and Martinez Moya, Ronny and Merkel, Marion and Spitz, Astrid and Wieland, Susanne and Hellmuth, Hendrik and Maurer, Karl-Heinz}, title = {Leistungsverbesserte Proteasevariante [Offenlegungsschrift]}, publisher = {Deutsches Patent- und Markenamt / Europ{\"a}isches Patentamt / WIPO}, address = {M{\"u}nchen / Den Hague / Genf}, pages = {1 -- 29}, year = {2012}, language = {de} } @misc{MaurerO'ConnellSiegertetal.2012, author = {Maurer, Karl-Heinz and O'Connell, Timothy and Siegert, Petra and Weber, Thomas and Tondera, Susanne and Hellmuth, Hendrik}, title = {Fl{\"u}ssige Tensidzubereitung enthaltend Lipase und Phosphonat [Offenlegungsschrift]}, publisher = {Deutsches Patent- und Markenamt / Europ{\"a}isches Patentamt / WIPO}, address = {M{\"u}nchen / Den Hague / Genf}, pages = {1 -- 22}, year = {2012}, language = {de} } @misc{SiegertMerkelHellmuthetal.2012, author = {Siegert, Petra and Merkel, Marion and Hellmuth, Hendrik and O'Connell, Timothy and Maurer, Karl-Heinz}, title = {Stabilisierte fl{\"u}ssige enzymhaltige Tensidzubereitung (Einsatz einer das hydrolytische Enzym stabilisierenden Komponente, die eine Phenylalkyldicarbons{\"a}ure umfasst) [Offenlegungsschrift]}, publisher = {Deutsches Patent- und Markenamt / Europ{\"a}isches Patentamt / WIPO}, address = {M{\"u}nchen / Den Hague / Genf}, pages = {1 -- 15}, year = {2012}, language = {de} } @misc{SiegertMerkelHellmuthetal.2012, author = {Siegert, Petra and Merkel, Marion and Hellmuth, Hendrik and O'Connell, Timothy and Maurer, Karl-Heinz}, title = {Stabilisierte fl{\"u}ssige enzymhaltige Tensidzubereitung (durch den Einsatz einer das hydrolytische Enzym stabilisierende Komponente, die eine mehrfach substituierte Benzolcarbons{\"a}ure umfasst, die an mindestens zwei Kohlenstoffatomen des Benzolrestes eine Carboxylgruppe aufweist) [Offenlegungsschrift]}, publisher = {Deutsches Patent- und Markenamt / Europ{\"a}isches Patentamt / WIPO}, address = {M{\"u}nchen / Den Hague / Genf}, pages = {1 -- 16}, year = {2012}, language = {de} } @misc{SiegertMerkelHellmuthetal.2012, author = {Siegert, Petra and Merkel, Marion and Hellmuth, Hendrik and O'Connell, Timothy and Maurer, Karl-Heinz}, title = {Stabilisierte fl{\"u}ssige enzymhaltige Tensidzubereitung (Einsatz einer das hydrolytische Enzym stabilisierende Komponente, die eine Phthaloylglutamins{\"a}ure und/oder eine Phthaloylasparagins{\"a}ure umfasst) [Offenlegungsschrift]}, publisher = {Deutsches Patent- und Markenamt / Europ{\"a}isches Patentamt / WIPO}, address = {M{\"u}nchen / Den Hague / Genf}, pages = {1 -- 16}, year = {2012}, language = {de} } @misc{SiegertMerkelHellmuthetal.2012, author = {Siegert, Petra and Merkel, Marion and Hellmuth, Hendrik and O'Connell, Timothy and Maurer, Karl-Heinz}, title = {Stabilisierte fl{\"u}ssige enzymhaltige Tensidzubereitung (Einsatz einer das hydrolytische Enzym stabilisierende Komponente, die eine Aminophthals{\"a}ure umfasst) [Offenlegungsschrift]}, publisher = {Deutsches Patent- und Markenamt / Europ{\"a}isches Patentamt / WIPO}, address = {M{\"u}nchen / Den Hague / Genf}, pages = {1 -- 16}, year = {2012}, language = {de} } @misc{SiegertMerkelHellmuthetal.2012, author = {Siegert, Petra and Merkel, Marion and Hellmuth, Hendrik and O'Connell, Timothy and Maurer, Karl-Heinz}, title = {Stabilisierte fl{\"u}ssige enzymhaltige Tensidzubereitung (Einsatz einer das hydrolytische Enzym stabilisierende Komponente, die eine Oligoamino-biphenyl-oligocarbons{\"a}ure umfasst) [Offenlegungsschrift]}, publisher = {Deutsches Patent- und Markenamt / Europ{\"a}isches Patentamt / WIPO}, address = {M{\"u}nchen / Den Hague / Genf}, pages = {1 -- 16}, year = {2012}, language = {de} } @article{KirchhofKraft2012, author = {Kirchhof, Michael and Kraft, Bodo}, title = {Hybrides Vorgehensmodell : Agile und klassische Methoden im Projekt passend kombinieren}, series = {ProjektMagazin}, journal = {ProjektMagazin}, number = {11}, publisher = {Berleb Media}, address = {Taufkirchen}, pages = {11 S.}, year = {2012}, abstract = {Agil ist im Trend und immer mehr Unternehmen, die ihre Projekte bisher nach klassischen Prinzipien durchf{\"u}hrten, denken {\"u}ber den Einsatz agiler Methoden nach. Doch selbst wenn die Organisation bereits beide Philosophien unterst{\"u}tzt, gilt f{\"u}r ein Projekt meist die klare Vorgabe: agil oder klassisch. Es gibt aber noch einen anderen Ansatz, mit diesen "unterschiedlichen Welten" umzugehen: Und zwar die beiden Philosophien innerhalb eines Projekts zu kombinieren. Wie dies in der Praxis aussehen und gelingen kann, zeigen Dr. Michael Kirchhof und Prof. Dr. Bodo Kraft in diesem Beitrag.}, language = {de} } @article{Baehr2012, author = {B{\"a}hr, Brigitte}, title = {[Gert Hoepner] im Interview zum Thema ; Verpackungspolitik - mehr als H{\"u}lle}, series = {Packaging journal : Technologie, Logistik, Marketing, Produkte}, journal = {Packaging journal : Technologie, Logistik, Marketing, Produkte}, number = {5}, publisher = {Ella Verlag}, address = {H{\"u}rth}, issn = {1610-0336}, pages = {78 -- 80}, year = {2012}, language = {de} } @book{HaynWalderseeBenzeletal.2012, author = {Hayn, Sven and Waldersee, Georg Graf and Benzel, Ute and Utzerath, Meike}, title = {HGB und Steuerbilanz im Vergleich: synoptische Darstellung von Handels- und Steuerbilanzrecht / Sven Hayn, Georg Graf Waldersee, Ute Benzel unter Mitarb. von Meike Utzerath ...}, edition = {2., {\"u}berarb. Aufl.}, publisher = {Sch{\"a}ffer-Poeschel}, address = {Stuttgart}, isbn = {978-3-7910-3222-1}, pages = {XIX, 188 S.}, year = {2012}, language = {de} } @article{LeidingerNoistenWollert2012, author = {Leidinger, Rafael and Noisten, Thomas and Wollert, J{\"o}rg}, title = {Realtime automation networks in moVing industrial environments}, series = {Journal of systemics, cybernetics and informatics}, volume = {Vol. 10}, journal = {Journal of systemics, cybernetics and informatics}, number = {Iss. 2}, publisher = {IIIC}, address = {Orlando}, issn = {1690-4532}, pages = {52 -- 56}, year = {2012}, abstract = {The radio-based wireless data communication has made the realization of new technical solutions possible in many fields of the automation technology (AT). For about ten years, a constant disproportionate growth of wireless technologies can be observed in the automation technology. However, it shows that especially for the AT, conventional technologies of office automation are unsuitable and/or not manageable. The employment of mobile services in the industrial automation technology has the potential of significant cost and time savings. This leads to an increased productivity in various fields of the AT, for example in the factory and process automation or in production logistics. In this paper technologies and solutions for an automation-suited supply of mobile wireless services will be introduced under the criteria of real time suitability, IT-security and service orientation. Emphasis will be put on the investigation and development of wireless convergence layers for different radio technologies, on the central provision of support services for an easy-to-use, central, backup enabled management of combined wired / wireless networks and on the study on integrability in a Profinet real-time Ethernet network.}, language = {en} } @inproceedings{Wollert2012, author = {Wollert, J{\"o}rg}, title = {The performance of UWB-communication in an industrial environment}, series = {IEEE 1st International Symposium on Wireless Systems : (IDAACS-SWS) : Offenburg, 20-21 Sept. 2012}, booktitle = {IEEE 1st International Symposium on Wireless Systems : (IDAACS-SWS) : Offenburg, 20-21 Sept. 2012}, publisher = {IEEE}, address = {Piscataway, NJ}, organization = {International Symposium on Wireless Systems <1, 2012, Offenburg>}, isbn = {978-1-4673-4678-8}, doi = {10.1109/IDAACS-SWS.2012.6377639}, pages = {85 -- 90}, year = {2012}, language = {en} } @inproceedings{WollertRau2012, author = {Wollert, J{\"o}rg and Rau, S.}, title = {Performance von embedded WLAN-Systemen bei koexistierenden Netzwerken}, series = {KOMMA 2012 : Kommunikation in der Automation : 3. Jahreskolloquium Kommunikation in der Automation : Lemgo, 14.11.2012 / J{\"u}rgen Jasperneite ... (Hrsg.)}, booktitle = {KOMMA 2012 : Kommunikation in der Automation : 3. Jahreskolloquium Kommunikation in der Automation : Lemgo, 14.11.2012 / J{\"u}rgen Jasperneite ... (Hrsg.)}, publisher = {Inst. f{\"u}r Industrielle Informationstechnik}, address = {Lemgo}, organization = {Jahreskolloquium Kommunikation in der Automation <3, 2012, Lemgo>}, isbn = {978-3-9814062-2-1}, pages = {1 CD-ROM}, year = {2012}, language = {de} } @incollection{WollertRau2012, author = {Wollert, J{\"o}rg and Rau, Sebastian}, title = {Energietransparenz und optimierter Energieverbrauch durch ganzheitliche Automatisierungskonzepte}, series = {Smart Energy 2012 : wie smart ist der Weg zur Energiewende? / Uwe Großmann, Ingo Kunold (Hrsg.)}, booktitle = {Smart Energy 2012 : wie smart ist der Weg zur Energiewende? / Uwe Großmann, Ingo Kunold (Hrsg.)}, publisher = {H{\"u}lsbusch}, address = {Gl{\"u}ckstadt}, isbn = {978-3-86488-030-8}, pages = {109 -- 122}, year = {2012}, language = {de} } @article{MottaghyDijkshoorn2012, author = {Mottaghy, Darius and Dijkshoorn, Lydia}, title = {Implementing an effective finite difference formulation for borehole heat exchangers into a heat and mass transport code}, series = {Renewable Energy}, volume = {45}, journal = {Renewable Energy}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0960-1481}, doi = {10.1016/j.renene.2012.02.013}, pages = {59 -- 71}, year = {2012}, abstract = {We present an effective finite difference formulation for implementing and modeling multiple borehole heat exchangers (BHE) in the general 3-D coupled heat and flow transport code SHEMAT. The BHE with arbitrary length can be either coaxial or double U-shaped. It is particularly suitable for modeling deep BHEs which contain varying pipe diameters and materials. Usually, in numerical simulations, a fine discretization of the BHE assemblage is required, due to the large geometric aspect ratios involved. This yields large models and long simulation times. The approach avoids this problem by considering heat transport between fluid and the soil through pipes and grout via thermal resistances. Therefore, the simulation time can be significantly reduced. The coupling with SHEMAT is realized by introducing an effective heat generation. Due to this connection, it is possible to consider heterogeneous geological models, as well as the influence of groundwater flow. This is particularly interesting when studying the long term behavior of a single BHE or a BHE field. Heating and cooling loads can enter the model with an arbitrary interval, e.g. from hourly to monthly values. When dealing with large BHE fields, computing times can be further significantly reduced by focusing on the temperature field around the BHEs, without explicitly modeling inlet and outlet temperatures. This allows to determine the possible migration of cold and warm plumes due to groundwater flow, which is of particular importance in urban areas with a high BHE installation density. The model is validated against the existing BHE modeling codes EWS and EED. A comparison with monitoring data from a deep BHE in Switzerland shows a good agreement. Synthetic examples demonstrate the field of application of this model.}, language = {en} } @incollection{Lind2012, author = {Lind, Thorsten Patric}, title = {Wirkungen der Er{\"o}ffnung des Insolvenzverfahrens : \S\S 129, 132, 133, 144, 145}, series = {Bankenkommentar zum Insolvenzrecht. - 2. Aufl.}, booktitle = {Bankenkommentar zum Insolvenzrecht. - 2. Aufl.}, publisher = {Finanz Colloquium}, address = {Heidelberg}, isbn = {978-3-943170-03-0}, pages = {1145 -- 1585}, year = {2012}, language = {de} } @article{EllrichLind2012, author = {Ellrich, Thomas and Lind, Thorsten Patric}, title = {Die 'kalte Zwangsverwaltung' durch den Insolvenzverwalter}, series = {Forderungs-Praktiker : WIKI}, journal = {Forderungs-Praktiker : WIKI}, number = {1}, publisher = {FCH}, address = {Heidelberg}, pages = {16 -- 21}, year = {2012}, language = {de} } @article{RostLind2012, author = {Rost, Kathrin Dorothea and Lind, Thorsten Patric}, title = {Die Aufrechnung des Insolvenzverwalters gegen eine Insolvenzforderung nach ihrer Feststellung}, series = {Zeitschrift f{\"u}r das gesamte Insolvenzrecht : ZInsO}, journal = {Zeitschrift f{\"u}r das gesamte Insolvenzrecht : ZInsO}, publisher = {Heymanns}, address = {K{\"o}ln}, issn = {1615-8032}, pages = {2179 -- 2187}, year = {2012}, language = {de} } @article{Lind2012, author = {Lind, Thorsten Patric}, title = {Zur Rechtsscheinhaftung bei Handeln einer Unternehmergesellschaft unter dem Rechtsformzusatz „GmbH" : Urteil vom 12.06.2012 - II ZR 256/11 : Anmerkung}, series = {Fachdienst Zivilrecht - LMK - Kommentierte BGH-Rechtsprechung, Lindenmaier-M{\"o}hring}, journal = {Fachdienst Zivilrecht - LMK - Kommentierte BGH-Rechtsprechung, Lindenmaier-M{\"o}hring}, number = {Ausg. 11}, publisher = {Beck}, address = {M{\"u}nchen}, issn = {1611-1095}, pages = {339268}, year = {2012}, language = {de} } @article{Lind2012, author = {Lind, Thorsten Patric}, title = {Rechtsprobleme bei der Liquidation der GmbH und der Gewinnaussch{\"u}ttung trotz bestehenden Anspruchs gegen den Gesellschafter : BGH, Urteil vom 23.04.2012 - II ZR 252/10 : Anmerkung}, series = {Fachdienst Zivilrecht - LMK - Kommentierte BGH-Rechtsprechung, Lindenmaier-M{\"o}hring}, journal = {Fachdienst Zivilrecht - LMK - Kommentierte BGH-Rechtsprechung, Lindenmaier-M{\"o}hring}, number = {Ausg. 10}, publisher = {Beck}, address = {M{\"u}nchen}, issn = {1611-1095}, pages = {338415}, year = {2012}, language = {de} } @article{Lind2012, author = {Lind, Thorsten Patric}, title = {Vollzug der Schenkung einer Unterbeteiligung : BGH, Urteil vom 29.11.2011 - II ZR 306/09 : Anmerkung}, series = {Fachdienst Zivilrecht - LMK - Kommentierte BGH-Rechtsprechung, Lindenmaier-M{\"o}hring}, journal = {Fachdienst Zivilrecht - LMK - Kommentierte BGH-Rechtsprechung, Lindenmaier-M{\"o}hring}, number = {Ausg. 4}, publisher = {Beck}, address = {M{\"u}nchen}, issn = {1611-1095}, pages = {330150}, year = {2012}, language = {de} } @article{Lind2012, author = {Lind, Thorsten Patric}, title = {Die Kostentragungspflicht bei der Aussonderung von Gegenst{\"a}nden, insbesondere bei Aufwendungen f{\"u}r den Ausbau einer Sache}, series = {Insb{\"u}ro : Zeitschrift f{\"u}r Insolvenzsachbearbeitung und Entschuldungsverfahren}, journal = {Insb{\"u}ro : Zeitschrift f{\"u}r Insolvenzsachbearbeitung und Entschuldungsverfahren}, number = {H. 3}, publisher = {Wolters Kluwer}, address = {K{\"o}ln}, issn = {1863-0731}, pages = {88 -- 89}, year = {2012}, language = {de} } @book{MeskourisButenwegHolleretal.2012, author = {Meskouris, Konstantin and Butenweg, Christoph and Holler, Stefan and Hake, Erwin}, title = {Baustatik in Beispielen}, edition = {2., bearb. Aufl.}, publisher = {Springer}, address = {Heidelberg ; Dordrecht ; London ; New York}, isbn = {978-3-642-23529-0 (Print) ; 978-3-642-23530-6 (E-Book)}, pages = {XI, 431 S.}, year = {2012}, language = {de} } @techreport{ButenwegDargelHoechstetal.2012, author = {Butenweg, Christoph and Dargel, H.-J. and H{\"o}chst, T. and Holtschoppen, B. and Schwarz, R. and Sippel, M.}, title = {Der Lastfall Erdbeben im Anlagenbau : Leitfaden : Entwurf, Bemessung und Konstruktion von Tragwerken und Komponenten in der chemischen Industrie in Anlehnung an die DIN EN 1998-1}, publisher = {Verband der Chemischen Industrie e.V.}, address = {Frankfurt}, pages = {20 S.}, year = {2012}, language = {de} } @incollection{ButenwegRoeser2012, author = {Butenweg, Christoph and Roeser, W.}, title = {Erdbebenbemessung von Stahlbetontragwerken nach DIN EN 1998-1}, series = {Stahlbetonbau aktuell : Praxishandbuch}, booktitle = {Stahlbetonbau aktuell : Praxishandbuch}, publisher = {Beuth}, address = {Berlin}, isbn = {978-3-410-21932-3 (Print) ; 978-341-02193-3-0 (E-Book)}, pages = {A.1 -- A.43}, year = {2012}, language = {de} } @incollection{KuhlmannButenwegMeskourisetal.2012, author = {Kuhlmann, Wolfram and Butenweg, Christoph and Meskouris, Konstantin and Kempen, Thomas}, title = {Simulation des Tragverhaltens des Aachener Doms im Erdbebenfall}, series = {Die karolingische Pfalzkapelle in Aachen : Material, Bautechnik, Restaurierung. (Arbeitshefte der rheinischen Denkmalpflege ; 78)}, booktitle = {Die karolingische Pfalzkapelle in Aachen : Material, Bautechnik, Restaurierung. (Arbeitshefte der rheinischen Denkmalpflege ; 78)}, publisher = {Wernersche Verlags-Gesellschaft}, address = {Worms}, isbn = {978-3-88462-325-1}, pages = {237 -- 248}, year = {2012}, language = {de} } @article{LaumannMainz2012, author = {Laumann, J{\"o}rg and Mainz, Stefan}, title = {Direkte Ermittlung der erforderlichen Einspanntiefe von I‑f{\"o}rmigen Stahlquerschnitten in Betonkonstruktionen}, volume = {81}, number = {11}, publisher = {Wiley}, address = {Weinheim}, issn = {1437-1049}, doi = {10.1002/stab.201201620}, pages = {850 -- 860}, year = {2012}, abstract = {F{\"u}r die Ermittlung der erforderlichen Einspanntiefe von eingespannten Stahlquerschnitten in Betonkonstruktionen existieren verschiedene Bemessungsmodelle. Diese basieren vorwiegend auf Grundlage nationaler Normen wie z. B. DIN 18800 [1] und DIN 1045 [2], die durch die europ{\"a}ische Normung ersetzt wurden. Aus diesem Grund wird in diesem Aufsatz ein Berechnungsmodell f{\"u}r die erforderliche Einspanntiefe von eingespannten Stahlquerschnitten in Betonkonstruktionen auf Grundlage des Eurocodes vorgestellt. Das Grundger{\"u}st f{\"u}r dieses Berechnungsmodell bildet das Verfahren nach Kindmann und Laumann, welches in [3] behandelt wurde. Gleichzeitig werden neue Formeln zur direkten Ermittlung der Mindesteinspanntiefe vorgestellt. Behandelt werden gewalzte I-Profile f{\"u}r einachsige Biegung um die starke Achse (y-y) mit Drucknormalkraft.}, language = {de} } @inproceedings{Butenweg2012, author = {Butenweg, Christoph}, title = {Eurocode 8 : Erdbebenauslegung von Tragwerken}, series = {Eurocodes 2012 kompakt - Chancen nutzen : 36. Darmst{\"a}dter Massivbauseminar Zukunftsf{\"a}higes Planen und Bauen, 7. und 8. M{\"a}rz}, booktitle = {Eurocodes 2012 kompakt - Chancen nutzen : 36. Darmst{\"a}dter Massivbauseminar Zukunftsf{\"a}higes Planen und Bauen, 7. und 8. M{\"a}rz}, publisher = {Freunde des Inst. f{\"u}r Massivbau der TU}, address = {Darmstadt}, organization = {Darmst{\"a}dter Massivbauseminar <36, 2012>}, pages = {257 -- 272}, year = {2012}, language = {de} } @book{Thomas2012, author = {Thomas, Axel}, title = {Rhetorische Knallfr{\"o}sche - reloaded : Zitatensammlung f{\"u}r Politik und Wirtschaft}, publisher = {Neck + Heyn}, address = {Aachen}, pages = {201 S. : Ill.}, year = {2012}, language = {de} } @misc{AhlbornGerlachIkenetal.2012, author = {Ahlborn, Kristina and Gerlach, Frank and Iken, Heiko and Sch{\"o}ning, Michael Josef and Vonau, Winfried}, title = {Miniaturisierte, potentiometrische Indikatorelektrode und Verfahren zu deren Herstellung : Offenlegungsschrift}, pages = {7 S.}, year = {2012}, language = {de} } @inproceedings{DachwaldFeldmannEspeetal.2012, author = {Dachwald, Bernd and Feldmann, Marco and Espe, Clemens and Plescher, Engelbert and Konstantinidis, K. and Forstner, R.}, title = {Enceladus explorer - A maneuverable subsurface probe for autonomous navigation through deep ice}, series = {63rd International Astronautical Congress 2012, IAC 2012; Naples; Italy; 1 October 2012 through 5 October 2012. (Proceedings of the International Astronautical Congress, IAC ; 3)}, booktitle = {63rd International Astronautical Congress 2012, IAC 2012; Naples; Italy; 1 October 2012 through 5 October 2012. (Proceedings of the International Astronautical Congress, IAC ; 3)}, publisher = {Curran}, address = {Red Hook, NY}, organization = {International Astronautical Congress <63, 2012, Napoli>}, isbn = {978-1-62276-979-7}, pages = {1756 -- 1766}, year = {2012}, language = {en} } @inproceedings{KernSchelthoffMathieu2012, author = {Kern, Alexander and Schelthoff, Christof and Mathieu, Moritz}, title = {Calculation of interception efficiencies for mesh-type air-terminations according to IEC 62305-3 using a dynamic electro-geometrical model}, series = {International Conference on Lightning Protection (ICLP) : 2 - 7 Sept. 2012, Vienna}, booktitle = {International Conference on Lightning Protection (ICLP) : 2 - 7 Sept. 2012, Vienna}, publisher = {IEEE}, address = {Piscataway, NJ}, organization = {International Conference on Lightning Protection <2012, Wien>}, isbn = {978-1-4673-1896-9 (E-Book) ; 978-1-4673-1898-3 (Print)}, pages = {1 -- 6}, year = {2012}, language = {en} } @inproceedings{LoPiparoKernMazzetti2012, author = {Lo Piparo, G. B. and Kern, Alexander and Mazzetti, C.}, title = {Some masterpoints about risk due to lightning}, series = {International Conference on Lightning Protection (ICLP) : 2 - 7 Sept. 2012, Vienna}, booktitle = {International Conference on Lightning Protection (ICLP) : 2 - 7 Sept. 2012, Vienna}, publisher = {IEEE}, address = {Piscataway, NJ}, organization = {International Conference on Lightning Protection <2012, Wien>}, isbn = {978-1-4673-1896-9 (E-Book) ; 978-1-4673-1898-3 (Print)}, pages = {1 -- 6}, year = {2012}, language = {en} } @article{BragardvanHoekDeDoncker2012, author = {Bragard, Michael and van Hoek, H. and De Doncker, R. W.}, title = {A major design step in IETO concept realization that allows overcurrent protection and pushes limits of switching performance}, series = {IEEE transactions on power electronics}, volume = {27}, journal = {IEEE transactions on power electronics}, number = {9}, publisher = {IEEE}, address = {New York}, issn = {0885-8993}, doi = {10.1109/TPEL.2012.2189136}, pages = {4163 -- 4171}, year = {2012}, abstract = {This paper presents the latest prototype of the integrated emitter turn-off thyristor concept, which potentially ranks among thyristor high-power devices like the gate turn-off thyristor and the integrated gate-commutated thyristor (IGCT). Due to modifications of the external driver stage and mechanical press-pack design optimization, this prototype allows for full device characterization. The turn-off capability was increased to 1600 A with an active silicon area of 823mm2 . This leads to a transient peak power of 672.1kW/cm² . Within this paper, measurements and concept assessment are presented and a comparison to state-of-the-art IGCT devices is provided.}, language = {en} } @article{BragardBragard2012, author = {Bragard, G. and Bragard, Michael}, title = {Ein kosteng{\"u}nstiges, universelles Modellbauinterface}, series = {Der mathematische und naturwissenschaftliche Unterricht : MNU ; Organ des Deutschen Vereins zur F{\"o}rderung des Mathematischen und Naturwissenschaftlichen Unterrichts e.V.}, volume = {65}, journal = {Der mathematische und naturwissenschaftliche Unterricht : MNU ; Organ des Deutschen Vereins zur F{\"o}rderung des Mathematischen und Naturwissenschaftlichen Unterrichts e.V.}, number = {5}, publisher = {Seeberger}, address = {Neuss}, issn = {0025-5866}, pages = {290 -- 293}, year = {2012}, abstract = {Wir stellen einen USB-Baustein vor, der eine kosteng{\"u}nstige und universelle M{\"o}glichkeit schafft , im Unterricht den Themenkreis Messen-Steuern-Regeln zu behandeln. Die Funktionalit{\"a}t orientiert sich am CVK-Interface der Firma Fischertechnik. Im Gegensatz zu kommerziellen L{\"o}sungen erlaubt unser Aufbau auch den preiswerten Einsatz in Gruppen- oder Einzelarbeit. Abschließend berichten wir {\"u}ber ein Beispiel aus dem Unterrichtseinsatz.}, language = {de} } @phdthesis{Bragard2012, author = {Bragard, Michael}, title = {The integrated emitter turn-off thyristor : an innovative MOS-gated high-power device. - (Aachener Beitr{\"a}ge des ISEA ; 62)}, publisher = {Shaker}, address = {Aachen}, isbn = {978-3-8440-1152-4}, pages = {III, 164 S. : Ill., graph. Darst.}, year = {2012}, abstract = {This thesis introduces the Integrated Emitter Turn-Off (IETO) Thyristor as a new high-power device. Known state-of-the-art research activities like the Dual GCT, the ETO thyristor and the ICT were presented and critically reviewed. A comparison with commercialized solutions identifies the pros and cons of each type of device family. Based on this analysis, the IETO structure is proposed, covering most benefits of each device class. In particular the combination of a MOS-assisted turn-off with a thyristor-based device allows a voltage-controlled MOS switching and the low on-state voltage of the thyristors. The following synthesis of an IETO device stands on a three-dimensional field of optimization spanned by electric, mechanical and thermal aspects. From an electric point of view, the lowest possible parasitic inductance and resistance within the commutation path are optimization criteria. The mechanical construction has to withstand the required contact pressure of multiple kilo Newtons. Finally, thermal borders limit the maximum average current of the device. FEM simulations covering these three aspects are performed for several design proposals. An IETO prototype is constructed and measurements on various test benches attest thermal, mechanical and electric performance. A local decoupling of the external driver stage and the presspack housing is presented by a cable connection. This separation enables a thermal and mechanical independence, which is advantageous in terms of vibrations and thermal cycles including increased reliability. The electric pulse performance of the prototype device is a factor of 3.1 above today''s solutions. In single-pulse measurements, a current up to 1600 A was successfully turned off at 115°C with an active silicon area of 823 mm². One reason for this increased turn-off capability is the extremely low-inductive construction. Additional functionality of the IETO thyristor like over-current self-protection and defined short-circuit failure state are successfully verified.}, language = {en} } @article{RiglingElkinDobbertinetal.2012, author = {Rigling, Andreas and Elkin, Ch{\´e} and Dobbertin, Matthias and Eilmann, Britta and Giuggiola, Arnaud and Wohlgemuth, Thomas and Bugmann, Harald}, title = {Wald und Klimawandel in der inneralpinen Trockenregion Visp}, series = {Schweizerische Zeitschrift f{\"u}r Forstwesen}, volume = {163}, journal = {Schweizerische Zeitschrift f{\"u}r Forstwesen}, number = {12}, publisher = {Schweizerischer Forstverein}, address = {Z{\"u}rich}, issn = {2235-1469 (Online)}, doi = {10.3188/szf.2012.0481}, pages = {481 -- 492}, year = {2012}, abstract = {Der Temperaturanstieg der vergangenen Jahrzehnte war in Gebirgsregionen besonders ausgepr{\"a}gt. Sollte sich dieser Temperaturtrend im 21. Jahrhundert fortsetzen, dann d{\"u}rf-ten sich auch die H{\"a}ufigkeit und Intensit{\"a}t von Niederschl{\"a}-gen und Trockenperioden ver{\"a}ndern, was die Waldwirtschaft vor grosse Herausforderungen stellen wird. Trockenheit ist ein entscheidender Faktor f{\"u}r die Wald{\"o}kosysteme der inner-alpinen T{\"a}ler, wo seit Jahren trockenheitsbedingtes Baum-sterben festgestellt wird. Der vorliegende Beitrag hat zum Ziel, die Sensitivit{\"a}t der verschiedenen Wald{\"o}kosysteme ge-gen{\"u}ber Klimawandel und alternative, teilweise extreme Bewirtschaftungsvarianten in der Region Visp zu testen. Me-thodische Ans{\"a}tze wie Monitoring, Feldexperimente und dy-namische Modellierung wurden kombiniert, und es wurden verschiedene {\"O}kosystemleistungen ber{\"u}cksichtigt, so Holz-produktion, Schutz vor Naturgefahren, Kohlenstoffspeiche-rung und Aspekte der Biodiversit{\"a}t. Die Resultate deuten da-rauf hin, dass auf den Trockenstandorten der Tieflagen die einheimischen Baumarten an ihre physiologischen Grenzen stossen und l{\"a}ngerfristig {\"u}ber alternative Baumarten nach-gedacht werden sollte. In den mittleren Lagen d{\"u}rften Tro-ckenheit und Schadinsekten wie die Borkenk{\"a}fer die zuk{\"u}nf-tige Waldentwicklung steuern. In den Hochlagen hingegen werden sich die W{\"a}lder ausdehnen und besser wachsen als heute. Alle untersuchten {\"O}kosystemleistungen werden ge-bietsweise starken Ver{\"a}nderungen unterworfen sein. Die dis-kutierten Bewirtschaftungsvarianten scheinen dazu geeignet, die Wasserverf{\"u}gbarkeit der Best{\"a}nde, haupts{\"a}chlich in tief-eren Lagen, zu erh{\"o}hen und dadurch die Widerstandskraft der B{\"a}ume gegen{\"u}ber Trockenperioden vor{\"u}bergehend zu st{\"a}rken. Es ist aber davon ausgehen, dass nur verh{\"a}ltnism{\"a}s-sig starke Eingriffe wesentliche Effekte erzielen k{\"o}nnen. Die Verkn{\"u}pfung von Umweltmonitoring, Feldexperimenten und Modellierung unter Miteinbezug von {\"O}kosystemleistungen ist vielversprechend, da sie eine differenzierte Absch{\"a}tzung des zuk{\"u}nftigen Landschaftswandels und seiner Effekte auf die Waldleistungen erm{\"o}glicht.}, language = {de} } @inproceedings{NoetzoldUphuesWegeneretal.2012, author = {N{\"o}tzold, K. and Uphues, A. and Wegener, R. and Soter, S. and Fink, K. and Bragard, Michael and Griessel, R.}, title = {Inverter based test setup for LVRT verification of a full-scale 2 MW wind power converter}, series = {EPE Joint Wind Energy and T\&D Chapters Seminar : 28th and 29th of June 2012, in the Utzon Centre, Aalborg, Denmark ; papers, posters, presentations. - Session 2: Grid connection, compliance}, booktitle = {EPE Joint Wind Energy and T\&D Chapters Seminar : 28th and 29th of June 2012, in the Utzon Centre, Aalborg, Denmark ; papers, posters, presentations. - Session 2: Grid connection, compliance}, publisher = {EPE Association}, address = {Brussels}, year = {2012}, language = {en} } @incollection{BagayokoGeisslerKoch2012, author = {Bagayoko, Lamine and Geissler, Karsten and Koch, Eckart}, title = {Dynamik bei Eisenbahnbr{\"u}cken}, series = {Stahlbau-Kalender : [Eurocode-3-Grundnorm; Br{\"u}cken] ; Jg. 14 / hrsg. von Ulrike Kuhlmann}, booktitle = {Stahlbau-Kalender : [Eurocode-3-Grundnorm; Br{\"u}cken] ; Jg. 14 / hrsg. von Ulrike Kuhlmann}, publisher = {Ernst \& Sohn}, address = {Berlin}, isbn = {978-3-433-02988-6}, pages = {575 -- 632}, year = {2012}, language = {de} } @article{EilmannRigling2012, author = {Eilmann, Britta and Rigling, Andreas}, title = {Tree-growth analyses to estimate tree species' drought tolerance}, series = {Tree Physiology}, volume = {32}, journal = {Tree Physiology}, number = {2}, editor = {Abrams, Marc}, publisher = {Oxford University Press}, address = {Oxford}, issn = {0829-318X (Print)}, doi = {10.1093/treephys/tps004}, pages = {178 -- 187}, year = {2012}, abstract = {Climate change is challenging forestry management and practices. Among other things, tree species with the ability to cope with more extreme climate conditions have to be identified. However, while environmental factors may severely limit tree growth or even cause tree death, assessing a tree species' potential for surviving future aggravated environmental conditions is rather demanding. The aim of this study was to find a tree-ring-based method suitable for identifying very drought-tolerant species, particularly potential substitute species for Scots pine (Pinus sylvestris L.) in Valais. In this inner-Alpine valley, Scots pine used to be the dominating species for dry forests, but today it suffers from high drought-induced mortality. We investigate the growth response of two native tree species, Scots pine and European larch (Larix decidua Mill.), and two non-native species, black pine (Pinus nigra Arnold) and Douglas fir (Pseudotsuga menziesii Mirb. var. menziesii), to drought. This involved analysing how the radial increment of these species responded to increasing water shortage (abandonment of irrigation) and to increasingly frequent drought years. Black pine and Douglas fir are able to cope with drought better than Scots pine and larch, as they show relatively high radial growth even after irrigation has been stopped and a plastic growth response to drought years. European larch does not seem to be able to cope with these dry conditions as it lacks the ability to recover from drought years. The analysis of trees' short-term response to extreme climate events seems to be the most promising and suitable method for detecting how tolerant a tree species is towards drought. However, combining all the methods used in this study provides a complete picture of how water shortage could limit species.}, language = {en} } @article{RiglingBiglerEilmannetal.2012, author = {Rigling, Andreas and Bigler, Christof and Eilmann, Britta and Feldmeyer-Christe, Elisabeth and Gimmi, Urs and Ginzler, Christian and Graf, Ulrich and Mayer, Phillip and Vacchiano, Giorgio and Weber, Pascal and Wohlgemuth, Thomas and zweifel, Roman and Dobbertin, Matthias}, title = {Driving factors of a vegetation shift from Scots pine to pubescent oak in dry Alpine forests}, series = {Global Change Biology}, volume = {19}, journal = {Global Change Biology}, number = {1}, publisher = {Wiley-Blackwell}, address = {Oxford}, issn = {1354-1013 (Print)}, doi = {10.1111/gcb.12038}, pages = {229 -- 240}, year = {2012}, abstract = {An increasing number of studies have reported on forest declines and vegetation shifts triggered by drought. In the Swiss Rhone valley (Valais), one of the driest inner-Alpine regions, the species composition in low elevation forests is changing: The sub-boreal Scots pine (Pinus sylvestris L.) dominating the dry forests is showing high mortality rates. Concurrently the sub-Mediterranean pubescent oak (Quercus pubescens Willd.) has locally increased in abundance. However, it remains unclear whether this local change in species composition is part of a larger-scale vegetation shift. To study variability in mortality and regeneration in these dry forests we analysed data from the Swiss national forest inventory (NFI) on a regular grid between 1983 and 2003, and combined it with annual mortality data from a monitoring site. Pine mortality was found to be highest at low elevation (below 1000 m a.s.l.). Annual variation in pine mortality was correlated with a drought index computed for the summer months prior to observed tree death. A generalized linear mixed-effects model indicated for the NFI data increased pine mortality on dryer sites with high stand competition, particularly for small-diameter trees. Pine regeneration was low in comparison to its occurrence in the overstorey, whereas oak regeneration was comparably abundant. Although both species regenerated well at dry sites, pine regeneration was favoured at cooler sites at higher altitude and oak regeneration was more frequent at warmer sites, indicating a higher adaptation potential of oaks under future warming. Our results thus suggest that an extended shift in species composition is actually occurring in the pine forests in the Valais. The main driving factors are found to be climatic variability, particularly drought, and variability in stand structure and topography. Thus, pine forests at low elevations are developing into oak forests with unknown consequences for these ecosystems and their goods and services.}, language = {en} } @inproceedings{WeilPoghossianSchoeningetal.2012, author = {Weil, M. and Poghossian, Arshak and Sch{\"o}ning, Michael Josef and Cherstvy, A.}, title = {Electrical monitoring of layer-by-layer adsorption of oppositely charged macromolecules by means of capacitive field-effect devices}, isbn = {978-3-9813484-2-2}, doi = {10.5162/IMCS2012/P2.5.2}, pages = {1575 -- 1578}, year = {2012}, language = {en} } @inproceedings{BohrnMuchaWerneretal.2012, author = {Bohrn, Ulrich and Mucha, Andreas and Werner, Frederik and St{\"u}tz, Evamaria and B{\"a}cker, Matthias and Krumbe, Christoph and Schienle, Meinrad and Fleischer, Maximilian and Wagner, Patrick and Sch{\"o}ning, Michael Josef}, title = {Detection of toxic chromium species in water using cellbased sensor systems}, isbn = {978-3-9813484-2-2}, doi = {10.5162/IMCS2012/P2.1.14}, pages = {1364 -- 1367}, year = {2012}, language = {en} } @inproceedings{BohrnStuetzFleischeretal.2012, author = {Bohrn, Ulrich and St{\"u}tz, Evamaria and Fleischer, Maximilian and Sch{\"o}ning, Michael Josef and Wagner, Patrick}, title = {Living cell-based gas sensor system for the detection of acetone in air}, isbn = {978-3-9813484-2-2}, doi = {10.5162/IMCS2012/3.2.3}, pages = {269 -- 272}, year = {2012}, language = {en} } @inproceedings{TakenagaWernerSawadaetal.2012, author = {Takenaga, Shoko and Werner, Frederik and Sawada, Kazuaki and Sch{\"o}ning, Michael Josef}, title = {Comparison of label-free ACh image sensors based on CCD and LAPS}, isbn = {978-3-9813484-2-2}, doi = {10.5162/IMCS2012/4.2.6}, pages = {356 -- 359}, year = {2012}, language = {en} } @article{SchoeningBaecker2012, author = {Sch{\"o}ning, Michael Josef and B{\"a}cker, Matthias}, title = {Chip-basierte Sensoren f{\"u}r die Biotechnik}, volume = {13}, number = {2}, publisher = {BIOCOM}, address = {Berlin}, issn = {1611-0854}, year = {2012}, language = {de} } @article{SpelthahnSchubertSchoening2012, author = {Spelthahn, Heiko and Schubert, J{\"u}rgen and Sch{\"o}ning, Michael Josef}, title = {D{\"u}nnschichtsensoren f{\"u}r die Schwermetallanalytik : Mikroelektroden auf Chalkogenidglasbasis}, series = {GIT Labor-Fachzeitschrift}, journal = {GIT Labor-Fachzeitschrift}, number = {4}, publisher = {Wiley-VCH}, address = {Weinheim}, pages = {285 -- 287}, year = {2012}, abstract = {Die Detektion von Schadstoffen repr{\"a}sentiert in der Umweltanalytik eine wichtige Aufgabenstellung. Gerade die Abwasser- bzw. Brauchwasseranalytik sowie die Prozesskontrolle haben einen hohen Stellenwert. Siliziumbasierte D{\"u}nnschichtsensoren bieten eine kosteng{\"u}nstige M{\"o}glichkeit, „online"-Messungen bzw. Vor-Ort-Messungen zeitnah durchzuf{\"u}hren. In dieser Arbeit wird ein potentiometrisches Sensorarray auf der Basis von Chalkogenidgl{\"a}sern zur Detektion von Schwermetallen in w{\"a}ssrigen Medien vorgestellt.}, language = {de} } @inproceedings{RitzTerhaarWallenborn2012, author = {Ritz, Thomas and Terhaar, Kristin and Wallenborn, Ramona}, title = {HMI f{\"u}r eCarSharing : ein Baustein f{\"u}r nachhaltige Mobilit{\"a}t}, series = {Mensch \& Computer 2012 - Workshopband : 12. Fach{\"u}bergreifende Konferenz f{\"u}r interaktive und kooperative Medien ; interaktiv informiert - allgegenw{\"a}rtig und allumfassend!?}, booktitle = {Mensch \& Computer 2012 - Workshopband : 12. Fach{\"u}bergreifende Konferenz f{\"u}r interaktive und kooperative Medien ; interaktiv informiert - allgegenw{\"a}rtig und allumfassend!?}, editor = {Reiterer, Harald}, publisher = {Oldenbourg}, address = {M{\"u}nchen}, isbn = {978-3-486-71990-1 (Print)}, doi = {10.1524/9783486719918.341}, pages = {381 -- 388}, year = {2012}, language = {de} } @inproceedings{FuchsRitzStrauch2012, author = {Fuchs, Britta and Ritz, Thomas and Strauch, Jakob}, title = {Usability of mobile applications : dissemination of usability engineering in small and medium enterprises}, series = {Proceedings of the International Conference on Data Communication Networking, e-Business and Optical Communication Systems : Rome, Italy, 24 - 27 July, 2012 ; [integrated in the ICETE (International Conference on e-Business and Telecommunications)]}, booktitle = {Proceedings of the International Conference on Data Communication Networking, e-Business and Optical Communication Systems : Rome, Italy, 24 - 27 July, 2012 ; [integrated in the ICETE (International Conference on e-Business and Telecommunications)]}, editor = {Obaidat, Mohammad S.}, publisher = {SciTePress}, address = {[Lissabon]}, isbn = {978-989-8565-23-5}, pages = {272 -- 277}, year = {2012}, language = {en} } @inproceedings{RitzStrauch2012, author = {Ritz, Thomas and Strauch, Jakob}, title = {Strukturierte Ermittlung beeinflussender Faktoren f{\"u}r mobile Softwarel{\"o}sungen}, series = {MMS 2012 : mobile und ubiquit{\"a}re Informationssysteme ; 7. Konferenz zur "Mobile und Ubiquit{\"a}re Informationssysteme" ; 01 - 02. M{\"a}rz 2012 in Braunschweig, Germany. - (GI-Edition lecture notes in informatics ; 202)}, booktitle = {MMS 2012 : mobile und ubiquit{\"a}re Informationssysteme ; 7. Konferenz zur "Mobile und Ubiquit{\"a}re Informationssysteme" ; 01 - 02. M{\"a}rz 2012 in Braunschweig, Germany. - (GI-Edition lecture notes in informatics ; 202)}, editor = {Back, Andrea}, publisher = {Ges. f{\"u}r Informatik}, address = {Bonn}, isbn = {978-3-88579-296-3 (CD-ROM-Ausg.)}, year = {2012}, language = {de} } @inproceedings{KoetterDeckerDetzleretal.2012, author = {K{\"o}tter, Jens and Decker, Stefan and Detzler, Raphael and Sch{\"a}fer, Jochen and Schmitz, Mark and Herrmann, Ulf}, title = {Cost Reduction of Solar Fields with HelioTrough Collector}, publisher = {FLAGSOL}, address = {K{\"o}ln}, pages = {9 S. : Ill., graph. Darst.}, year = {2012}, language = {en} } @article{FissabreLohmann2012, author = {Fissabre, Anke and Lohmann, Daniel}, title = {Verlust einer „tragenden Wand" : Das Haus der Jugend von Rudolf Schwarz in Aachen}, series = {Bauwelt}, volume = {103}, journal = {Bauwelt}, number = {45}, publisher = {Bauverlag BV}, address = {G{\"u}tersloh}, issn = {0005-6855}, pages = {6 -- 7}, year = {2012}, language = {de} } @inproceedings{FissabreWilson2012, author = {Fissabre, Anke and Wilson, Ariane}, title = {"Lehmbaupropaganda" - Gegens{\"a}tzliche Ideologien {\"u}ber Nachhaltigkeit in der Literatur {\"u}ber den Lehmbau}, series = {Lehm 2012 : Tagungsbeitr{\"a}ge der 6. Internationalen Fachtagung f{\"u}r Lehmbau = 6th International Conference on Building with Earth}, booktitle = {Lehm 2012 : Tagungsbeitr{\"a}ge der 6. Internationalen Fachtagung f{\"u}r Lehmbau = 6th International Conference on Building with Earth}, publisher = {Eigenverl. Dachverband Lehm}, address = {Weimar}, isbn = {9783000396496}, pages = {200 -- 213}, year = {2012}, language = {de} } @inproceedings{FissabreSchmidtSonnleitner2012, author = {Fissabre, Anke and Schmidt, Klaus and Sonnleitner, Andrea}, title = {Das Lehnsm{\"u}hlschloß in Ortrand - ein s{\"a}chsisches Herrenhaus der Renaissance}, series = {Wandel im Wohnbau zwischen Gotik und Barock : die s{\"a}chsisch-b{\"o}hmische Entwicklung im {\"u}berregionalen Vergleich}, booktitle = {Wandel im Wohnbau zwischen Gotik und Barock : die s{\"a}chsisch-b{\"o}hmische Entwicklung im {\"u}berregionalen Vergleich}, publisher = {Jonas}, address = {Marburg}, isbn = {978-3-89445-390-9}, pages = {487 -- 501}, year = {2012}, language = {de} } @incollection{BorchertLintzel2012, author = {Borchert, J{\"o}rg and Lintzel, P.}, title = {Risiken des Handels}, series = {Energiehandel in Europa}, booktitle = {Energiehandel in Europa}, editor = {Zenke, Ines}, edition = {3. Aufl.}, publisher = {Beck}, address = {M{\"u}nchen}, isbn = {978-3-9813142-9-8}, pages = {303 -- 312}, year = {2012}, language = {de} } @incollection{Borchert2012, author = {Borchert, J{\"o}rg}, title = {Aufbau von Handelseinheiten}, series = {Energiehandel in Europa}, booktitle = {Energiehandel in Europa}, editor = {Zenke, Ines}, edition = {3. Aufl.}, publisher = {Beck}, address = {M{\"u}nchen}, isbn = {978-3-406-63237-2}, pages = {467 -- 479}, year = {2012}, language = {de} } @incollection{BorchertMichels2012, author = {Borchert, J{\"o}rg and Michels, A.}, title = {Beschaffungsstrategien an der Schnittstelle Energiehandel / Vertrieb}, series = {Energiehandel in Europa}, booktitle = {Energiehandel in Europa}, editor = {Zenke, ines}, edition = {3. Aufl.}, publisher = {Beck}, address = {M{\"u}nchen}, isbn = {978-3-406-63237-2}, pages = {508 -- 522}, year = {2012}, language = {de} } @incollection{Vismann2012, author = {Vismann, Ulrich}, title = {Stahlbetonbau}, series = {Wendehorst Beispiele aus der Baupraxis. - 4. Aufl.}, booktitle = {Wendehorst Beispiele aus der Baupraxis. - 4. Aufl.}, publisher = {Springer Vieweg}, address = {Wiesbaden}, isbn = {978-3-8348-0999-5 ; 978-3-8348-8229-5}, doi = {10.1007/978-3-8348-8229-5_9}, pages = {223 -- 262}, year = {2012}, language = {de} } @incollection{StroetmannLohse2012, author = {Stroetmann, Richard and Lohse, Wolfram}, title = {Stahlbau}, series = {Wendehorst Beispiele aus der Baupraxis. - 4. Aufl.}, booktitle = {Wendehorst Beispiele aus der Baupraxis. - 4. Aufl.}, publisher = {Springer Vieweg}, address = {Wiesbaden}, isbn = {978-3-8348-0999-5 ; 978-3-8348-8229-5}, doi = {10.1007/978-3-8348-8229-5_10}, pages = {263 -- 361}, year = {2012}, language = {de} } @incollection{Feiser2012, author = {Feiser, Johannes}, title = {Geotechnik}, series = {Wendehorst Beispiele aus der Baupraxis. - 4. Aufl.}, booktitle = {Wendehorst Beispiele aus der Baupraxis. - 4. Aufl.}, publisher = {Springer Vieweg}, address = {Wiesbaden}, isbn = {978-3-8348-0999-5 ; 978-3-8348-8229-5}, doi = {10.1007/978-3-8348-8229-5_14}, pages = {453 -- 495}, year = {2012}, language = {de} } @incollection{Strohmeier2012, author = {Strohmeier, Andreas}, title = {Siedlungswasserwirtschaft}, series = {Wendehorst Beispiele aus der Baupraxis. - 4. Aufl.}, booktitle = {Wendehorst Beispiele aus der Baupraxis. - 4. Aufl.}, publisher = {Springer Vieweg}, address = {Wiesbaden}, isbn = {978-3-8348-0999-5 ; 978-3-8348-8229-5}, doi = {10.1007/978-3-8348-8229-5_16}, pages = {527 -- 566}, year = {2012}, language = {de} } @incollection{Biener2012, author = {Biener, Ernst}, title = {Abfallwirtschaft}, series = {Wendehorst Beispiele aus der Baupraxis. - 4. Aufl.}, booktitle = {Wendehorst Beispiele aus der Baupraxis. - 4. Aufl.}, publisher = {Springer Vieweg}, address = {Wiesbaden}, isbn = {978-3-8348-0999-5 ; 978-3-8348-8229-5}, doi = {10.1007/978-3-8348-8229-5_17}, pages = {567 -- 603}, year = {2012}, language = {de} } @article{HenkenOosterhuisOehlschlaegeretal.2012, author = {Henken, F. E. and Oosterhuis, K. and {\"O}hlschl{\"a}ger, Peter and Bosch, L. and Hooijberg, E. and Haanen, J. B. A. G. and Steenbergen, R. D. M.}, title = {Preclinical safety evaluation of DNA vaccines encoding modified HPV16 E6 and E7}, series = {Vaccine}, volume = {30}, journal = {Vaccine}, number = {28}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0264-410X}, doi = {10.1016/j.vaccine.2012.04.013}, pages = {4259 -- 4266}, year = {2012}, abstract = {Persistent infection with high-risk human papillomaviruses (hrHPV) can result in the formation of anogenital cancers. As hrHPV proteins E6 and E7 are required for cancer initiation and maintenance, they are ideal targets for immunotherapeutic interventions. Previously, we have described the development of DNA vaccines for the induction of HPV16 E6 and E7 specific T cell immunity. These vaccines consist of 'gene-shuffled' (SH) versions of HPV16 E6 and E7 that were fused to Tetanus Toxin Fragment C domain 1 (TTFC) and were named TTFC-E6SH and TTFC-E7SH. Gene-shuffling was performed to avoid the risk of inducing malignant transformation at the vaccination site. Here, we describe the preclinical safety evaluation of these candidate vaccines by analysis of their transforming capacity in vitro using established murine fibroblasts (NIH 3T3 cells) and primary human foreskin keratinocytes (HFKs). We demonstrate that neither ectopic expression of TTFC-E6SH and TTFC-E7SH alone or in combination enabled NIH 3T3 cells to form colonies in soft agar. In contrast, expression of HPV16 E6WT and E7WT alone or in combination resulted in effective transformation. Similarly, retroviral transduction of HFKs from three independent donors with both TTFC-E6SH and TTFC-E7SH alone or in combination did not show any signs of immortalization. In contrast, the combined expression of E6WT and E7WT induced immortalization in HFKs from all donors. Based on these results we consider it justified to proceed to clinical evaluation of DNA vaccines encoding TTFC-E6SH and TTFC-E7SH in patients with HPV16 associated (pre)malignancies.}, language = {en} } @article{ImmelGruetzkeSpaeteetal.2012, author = {Immel, Timo and Gr{\"u}tzke, Martin and Sp{\"a}te, Anne-Katrin and Groth, Ulrich and {\"O}hlschl{\"a}ger, Peter and Huhn, Thomas}, title = {Synthesis and X-ray structure analysis of a heptacoordinate titanium(IV)-bis-chelate with enhanced in vivo antitumor efficacy}, series = {Chemical Communications}, volume = {48}, journal = {Chemical Communications}, number = {46}, publisher = {Royal Society of Chemistry}, address = {Cambridge}, issn = {1364-548X}, doi = {10.1039/C2CC31624B}, pages = {5790 -- 5792}, year = {2012}, abstract = {Chelate stabilization of a titanium(IV)-salan alkoxide by ligand exchange with 2,6-pyridinedicarboxylic acid (dipic) resulted in heptacoordinate complex 3 which is not redox-active, stable on silica gel and has increased aqueous stability. 3 is highly toxic in HeLa S3 and Hep G2 and has enhanced antitumor efficacy in a mouse cervical-cancer model.}, language = {en} } @book{Vismann2012, author = {Vismann, Ulrich}, title = {Wendehorst Beispiele aus der Baupraxis / Ulrich Vismann (Hrsg.). - 4., durchges. und aktualis. Aufl.}, publisher = {Springer Vieweg}, address = {Wiesbaden}, isbn = {978-3-8348-0999-5 ; 978-3-8348-8229-5}, doi = {10.1007/978-3-8348-8229-5}, pages = {X, 653 S.}, year = {2012}, language = {de} } @article{ButenwegHoltschoppen2012, author = {Butenweg, Christoph and Holtschoppen, Britta}, title = {Neuer VCI-Leitfaden f{\"u}r die erdbebensichere Auslegung von Industrieanlagen}, series = {Bauingenieur : die richtungsweisende Zeitschrift im Bauingenieurswesen ; offizielle Zeitschrift der VDI-Gesellschaft Bautechnik}, volume = {Band 87}, journal = {Bauingenieur : die richtungsweisende Zeitschrift im Bauingenieurswesen ; offizielle Zeitschrift der VDI-Gesellschaft Bautechnik}, publisher = {VDI Fachmedien}, address = {D{\"u}sseldorf}, issn = {1436-4867 (E-Journal); 0005-6650 (Print)}, pages = {S18}, year = {2012}, language = {de} } @article{ButenwegFehling2012, author = {Butenweg, Christoph and Fehling, Ekkehard}, title = {Hintergrund f{\"u}r die vereinfachten Regeln bei Mauerwerksgeb{\"a}uden im Erdbebenfall}, series = {Mauerwerk : European journal of masonry}, volume = {Volume 16}, journal = {Mauerwerk : European journal of masonry}, number = {Issue 3}, publisher = {Wiley}, address = {Weinheim}, issn = {1437-1022 (E-Journal); 1432-3427 (Print)}, doi = {10.1002/dama.201200537}, pages = {127 -- 137}, year = {2012}, abstract = {Bei der Ausarbeitung des nationalen Anwendungsdokumentes zur DIN EN 1998-1 waren die in der ENV-Fassung enthaltenen vereinfachten Regeln im Lichte aktueller Forschungsergebnisse zu {\"u}berpr{\"u}fen und zu {\"u}berarbeiten. Die gleiche Aufgabe stellte sich auch f{\"u}r die Neufassung der DIN 4149. In beiden F{\"a}llen sind neben konstruktiven Regeln f{\"u}r die Art und Anordnung der zur Geb{\"a}udeaussteifung heranzuziehenden W{\"a}nde im Grundriss Tabellen enthalten, die unter bestimmten Bedingungen den Entfall eines rechnerischen Nachweises der Tragw{\"a}nde im Erdbebenfall erm{\"o}glichen. Dies ist f{\"u}r Schwachbebengebiete, wie sie in Deutschland und anderen L{\"a}ndern Mitteleuropas anzutreffen sind, sinnvoll, um unn{\"o}tigen Rechenaufwand sowie Probleme mit der F{\"u}hrbarkeit von Nachweisen so weit wie m{\"o}glich auszuschalten. Im vorliegenden Beitrag werden die Hintergr{\"u}nde der vereinfachten Regeln diskutiert und die Ergebnisse der Anwendung mit verschiedenen Rechenverfahren verglichen und bewertet.}, language = {de} } @article{ButenwegGellert2012, author = {Butenweg, Christoph and Gellert, Christoph}, title = {Integrale Geb{\"a}udeplanung am Beispiel eines Geschossbaus in Ziegelmauerwerk}, series = {Mauerwerk : European journal of masonry}, volume = {Volume 16}, journal = {Mauerwerk : European journal of masonry}, number = {5}, publisher = {Wiley}, address = {Weinheim}, issn = {1437-1022 (E-Journal); 1432-3427 (Print)}, doi = {10.1002/dama.201200550}, pages = {247 -- 254}, year = {2012}, abstract = {Moderne Mauerwerksbauten m{\"u}ssen nach heutigen Anforderungen architektonisch, statisch, energetisch sowie schall- und brandschutztechnisch optimal ausgelegt sein. Aufgrund der Komplexit{\"a}t und engen Verzahnung der einzelnen Anforderungen ist eine integrale Geb{\"a}udeplanung zur Erzielung einer qualitativ hochwertigen Bauwerksl{\"o}sung unbedingt notwendig. Diese erfordert von den Fachplanern vertieftes Spezialwissen in den verschiedenen Bereichen, um insbesondere die Schnittstellen und Bauwerksdetails korrekt zu planen und auszuf{\"u}hren. Der Beitrag stellt die integrale Geb{\"a}udeplanung am Beispiel eines Geschossbaus in Ziegelbauweise mit L{\"o}sungen f{\"u}r wesentliche Detailpunkte vor}, language = {de} } @misc{BagheriDahmann2012, author = {Bagheri, Mohsen and Dahmann, Peter}, title = {Kletterroboter mit Gurtantrieb international [Offenlegungsschrift]}, publisher = {Deutsches Patentamt / Europ{\"a}isches Patentamt / WIPO / USPTO}, address = {M{\"u}nchen / Den Hague / Genf / Alexandria, Virginia}, pages = {1 -- 20}, year = {2012}, language = {de} } @article{Staat2012, author = {Staat, Manfred}, title = {Limit and shakedown analysis under uncertainty}, series = {Tap chi Khoa hoc \& ung dung - Dai hoc Ton Duc Thang}, volume = {19}, journal = {Tap chi Khoa hoc \& ung dung - Dai hoc Ton Duc Thang}, pages = {45 -- 47}, year = {2012}, language = {en} } @article{Wilke2012, author = {Wilke, Thomas}, title = {Architekturzeichnung als Instrument der Theoriebildung. Lineamenta vs. Portraicture - Architekturdarstellung zwischen Wissenschaft und {\"O}ffentlichkeit. Tagung des DFG-Netzwerks-Schnittstelle Bild in Zusammenarbeit mit dem Lehrstuhl f{\"u}r Kunstgeschichte der Universit{\"a}t Regensburg, 28.4.2012.}, series = {Kunstchronik}, volume = {65}, journal = {Kunstchronik}, number = {9/10}, publisher = {Fachverlag Hans Carl}, address = {N{\"u}rnberg}, issn = {0023-5474}, pages = {494 -- 499}, year = {2012}, language = {de} } @article{ScheerBalimaneHaywardetal.2012, author = {Scheer, Nico and Balimane, Praveen and Hayward, Michael D. and Buechel, Sandra and Kauselmann, Gunther and Wolf, C. Roland}, title = {Generation and Characterization of a Novel Multidrug Resistance Protein 2 Humanized Mouse Line}, series = {Drug Metabolism and Disposition}, volume = {40}, journal = {Drug Metabolism and Disposition}, number = {11}, publisher = {ASPET}, address = {Bethesda, Md.}, issn = {1521-0111}, doi = {10.1124/dmd.112.047605}, pages = {2212 -- 2218}, year = {2012}, abstract = {The multidrug resistance protein (MRP) 2 is predominantly expressed in liver, intestine, and kidney, where it plays an important role in the excretion of a range of drugs and their metabolites or endogenous compounds into bile, feces, and urine. Mrp knockout [Mrp2(-/-)] mice have been used recently to study the role of MRP2 in drug disposition. Here, we describe the first generation and initial characterization of a mouse line humanized for MRP2 (huMRP2), which is nulled for the mouse Mrp2 gene and expresses the human transporter in the organs and cell types where MRP2 is normally expressed. Analysis of the mRNA expression for selected cytochrome P450 and transporter genes revealed no major changes in huMRP2 mice compared with wild-type controls. We show that human MRP2 is able to compensate functionally for the loss of the mouse transporter as demonstrated by comparable bilirubin levels in the humanized mice and wild-type controls, in contrast to the hyperbilirubinemia phenotype that is observed in MRP2(-/-) mice. The huMRP2 mouse provides a model to study the role of the human transporter in drug disposition and in assessing the in vivo consequences of inhibiting this transporter by compounds interacting with human MRP2.}, language = {en} } @article{ScheerKapelyukhRodeetal.2012, author = {Scheer, Nico and Kapelyukh, Yury and Rode, Anja and Buechel, Sandra and Wolf, C. Roland}, title = {Generation and characterization of novel cytochrome P450 Cyp2c gene cluster knockout and CYP2C9 humanized mouse lines}, series = {Molecular Pharmacology}, volume = {82}, journal = {Molecular Pharmacology}, number = {6}, publisher = {ASPET}, address = {Bethesda, Md.}, issn = {1521-0111}, doi = {10.1124/mol.112.080036}, pages = {1022 -- 1029}, year = {2012}, abstract = {Compared with rodents and many other animal species, the human cytochrome P450 (P450) Cyp2c gene cluster varies significantly in the multiplicity of functional genes and in the substrate specificity of its enzymes. As a consequence, the use of wild-type animal models to predict the role of human CYP2C enzymes in drug metabolism and drug-drug interactions is limited. Within the human CYP2C cluster CYP2C9 is of particular importance, because it is one of the most abundant P450 enzymes in human liver, and it is involved in the metabolism of a wide variety of important drugs and environmental chemicals. To investigate the in vivo functions of cytochrome P450 Cyp2c genes and to establish a model for studying the functions of CYP2C9 in vivo, we have generated a mouse model with a deletion of the murine Cyp2c gene cluster and a corresponding humanized model expressing CYP2C9 specifically in the liver. Despite the high number of functional genes in the mouse Cyp2c cluster and the reported roles of some of these proteins in different biological processes, mice deleted for Cyp2c genes were viable and fertile but showed certain phenotypic alterations in the liver. The expression of CYP2C9 in the liver also resulted in viable animals active in the metabolism and disposition of a number of CYP2C9 substrates. These mouse lines provide a powerful tool for studying the role of Cyp2c genes and of CYP2C9 in particular in drug disposition and as a factor in drug-drug interaction.}, language = {en} } @article{LempiaeinenCouttetBolognanietal.2012, author = {Lempi{\"a}inen, Harri and Couttet, Philippe and Bolognani, Federico and M{\"u}ller, Arne and Dubost, Val{\´e}rie and Luisier, Rapha{\"e}lle and Rio-Espinola, Alberto del and Vitry, Veronique and Unterberger, Elif B. and Thomson, John P. and Treindl, Fridolin and Metzger, Ute and Wrzodek, Clemens and Hahne, Florian and Zollinger, Tulipan and Brasa, Sarah and Kalteis, Magdalena and Marcellin, Magali and Giudicelli, Fanny and Braeuning, Albert and Morawiec, Laurent and Zamurovic, Natasa and L{\"a}ngle, Ulrich and Scheer, Nico and Sch{\"u}beler, Dirk and Goodman, Jay and Chibout, Salah-Dine and Marlowe, Jennifer and Theil, Dietlinde and Heard, David J. and Grenet, Olivier and Zell, Andreas and Templin, Markus F. and Meehan, Richard R. and Wolf, Roland C. and Elcombe, Clifford R. and Schwarz, Michael and Moulin, Pierre and Terranova, R{\´e}mi and Moggs, Jonathan G.}, title = {Identification of Dlk1-Dio3 imprinted gene cluster non-coding RNAs as novel candidate biomarkers for liver tumor promotion}, series = {Toxicological Sciences}, volume = {131}, journal = {Toxicological Sciences}, number = {2}, publisher = {Oxford University Press}, address = {Oxford}, issn = {1094-2025}, doi = {10.1093/toxsci/kfs303}, pages = {375 -- 386}, year = {2012}, abstract = {The molecular events during nongenotoxic carcinogenesis and their temporal order are poorly understood but thought to include long-lasting perturbations of gene expression. Here, we have investigated the temporal sequence of molecular and pathological perturbations at early stages of phenobarbital (PB) mediated liver tumor promotion in vivo. Molecular profiling (mRNA, microRNA [miRNA], DNA methylation, and proteins) of mouse liver during 13 weeks of PB treatment revealed progressive increases in hepatic expression of long noncoding RNAs and miRNAs originating from the Dlk1-Dio3 imprinted gene cluster, a locus that has recently been associated with stem cell pluripotency in mice and various neoplasms in humans. PB induction of the Dlk1-Dio3 cluster noncoding RNA (ncRNA) Meg3 was localized to glutamine synthetase-positive hypertrophic perivenous hepatocytes, sug- gesting a role for β-catenin signaling in the dysregulation of Dlk1-Dio3 ncRNAs. The carcinogenic relevance of Dlk1-Dio3 locus ncRNA induction was further supported by in vivo genetic dependence on constitutive androstane receptor and β-catenin pathways. Our data identify Dlk1-Dio3 ncRNAs as novel candidate early biomarkers for mouse liver tumor promotion and provide new opportunities for assessing the carcinogenic potential of novel compounds.}, language = {en} } @article{ScheerKapelyukhMcEwanetal.2012, author = {Scheer, Nico and Kapelyukh, Yury and McEwan, Jillian and Beuger, Vincent and Stanley, Lesley A. and Rode, Anja and Wolf, C. Roland}, title = {Modeling Human Cytochrome P450 2D6 Metabolism and Drug-drug Interaction by a Novel Panel of Knockout and Humanized Mouse Lines}, series = {Molecular Pharmacology}, volume = {81}, journal = {Molecular Pharmacology}, number = {1}, publisher = {ASPET}, address = {Bethesda, Md.}, issn = {1521-0111}, doi = {10.1124/mol.111.075192}, pages = {63 -- 72}, year = {2012}, abstract = {The highly polymorphic human cytochrome P450 2D6 enzyme is involved in the metabolism of up to 25\% of all marketed drugs and accounts for significant individual differences in response to CYP2D6 substrates. Because of the differences in the multiplicity and substrate specificity of CYP2D family members among species, it is difficult to predict pathways of human CYP2D6-dependent drug metabolism on the basis of animal studies. To create animal models that reflect the human situation more closely and that allow an in vivo assessment of the consequences of differential CYP2D6 drug metabolism, we have developed a novel straightforward approach to delete the entire murine Cyp2d gene cluster and replace it with allelic variants of human CYP2D6. By using this approach, we have generated mouse lines expressing the two frequent human protein isoforms CYP2D6.1 and CYP2D6.2 and an as yet undescribed variant of this enzyme, as well as a Cyp2d cluster knockout mouse. We demonstrate that the various transgenic mouse lines cover a wide spectrum of different human CYP2D6 metabolizer phenotypes. The novel humanization strategy described here provides a robust approach for the expression of different CYP2D6 allelic variants in transgenic mice and thus can help to evaluate potential CYP2D6-dependent interindividual differences in drug response in the context of personalized medicine.}, language = {en} } @article{MansurovDigelBiisenbaevetal.2012, author = {Mansurov, Z. and Digel, Ilya and Biisenbaev, M. and Savistkaya, I. and Kistaubaeva, A. and Akimbekov, Nuraly S. and Zhubanova, A.}, title = {Bio-composite material on the basis of carbonized rice husk in biomedicine and environmental applications}, series = {Eurasian Chemico-Technological Journal}, volume = {14}, journal = {Eurasian Chemico-Technological Journal}, number = {2}, publisher = {Institute of Combustion Problems}, address = {Almaty}, issn = {2522-4867}, doi = {10.18321/ectj105}, pages = {115 -- 131}, year = {2012}, language = {en} } @inproceedings{BitzKraffOrzadaetal.2012, author = {Bitz, Andreas and Kraff, O. and Orzada, S. and Maderwald, S. and Brote, I. and Johst, S. and Ladd, E.}, title = {Assessment of RF Safety of Transmit Coils at 7 Tesla by Experimental and Numerical Procedures (490.)}, series = {19th annual ISMRM scientific meeting and exhibition 2011 : Montreal, Quebec, Canada, 7 - 13 May 2011}, booktitle = {19th annual ISMRM scientific meeting and exhibition 2011 : Montreal, Quebec, Canada, 7 - 13 May 2011}, number = {Volume 1}, publisher = {Curran}, address = {Red Hook, NY}, isbn = {978-1-61839-284-8}, pages = {475}, year = {2012}, language = {en} } @article{PaulssenKongArciszewskietal.2012, author = {Paulßen, Elisabeth and Kong, Shushu and Arciszewski, Pawel and Wielbalck, Swantje and Abram, Ulrich}, title = {Aryl and NHC Compounds of Technetium and Rhenium}, series = {Journal of the American Chemical Society}, volume = {134}, journal = {Journal of the American Chemical Society}, number = {22}, publisher = {ACS Publications}, address = {Washington, DC}, issn = {1520-5126}, doi = {10.1021/ja3033718}, pages = {9118 -- 9121}, year = {2012}, abstract = {Air- and water-stable phenyl complexes with nitridotechnetium(V) cores can be prepared by straightforward procedures. [TcNPh2(PPh3)2] is formed by the reaction of [TcNCl2(PPh3)2] with PhLi. The analogous N-heterocyclic carbene (NHC) compound [TcNPh2(HLPh)2], where HLPh is 1,3,4-triphenyl-1,2,4-triazol-5-ylidene, is available from (NBu4)[TcNCl4] and HLPh or its methoxo-protected form. The latter compound allows the comparison of different Tc-C bonds within one compound. Surprisingly, the Tc chemistry with such NHCs does not resemble that of corresponding Re complexes, where CH activation and orthometalation dominate.}, language = {en} }