@article{TrappLammersEngudaretal.2023, author = {Trapp, Svenja and Lammers, Tom and Engudar, Gokce and Hoehr, Cornelia and Denkova, Antonia G. and Paulßen, Elisabeth and de Kruijff, Robin M.}, title = {Membrane-based microfluidic solvent extraction of Ga-68 from aqueous Zn solutions: towards an automated cyclotron production loop}, series = {EJNMMI Radiopharmacy and Chemistry}, volume = {2023}, journal = {EJNMMI Radiopharmacy and Chemistry}, number = {8, Article number: 9}, publisher = {Springer Nature}, issn = {2365-421X}, doi = {10.1186/s41181-023-00195-2}, pages = {1 -- 14}, year = {2023}, language = {en} } @masterthesis{Hosseinpour2023, type = {Bachelor Thesis}, author = {Hosseinpour, Seywan}, title = {Velum : Zensur des Visuellen im Iran}, publisher = {FH Aachen}, address = {Aachen}, school = {Fachhochschule Aachen}, pages = {153 Seiten}, year = {2023}, abstract = {Dieses multimediale Projekt thematisiert Zensur aus verschiedenen Dimensionen in totalit{\"a}ren, religi{\"o}s-patriarchalischen L{\"a}ndern, insbesondere im Iran. Dadurch wird versucht, mit einem denunzierenden Ansatz zu zeigen, wie Bilder zensiert werden und welche Auswirkungen diese zensierten Bilder auf Betrachter:innen haben. Dabei ist es auch wichtig, wie das Unsichtbare analysiert und verstanden wird. Die Opposition zwischen dem Akt des Visualisierens/Sichtbarmachens und Verbergens/Unsichtbarmachens in den meisten Bildern impliziert die Dialektik von Verh{\"u}llung und Enth{\"u}llung. Das Projekt »Velum« erm{\"o}glicht es den Betrachter:innen, die Zensurpraktiken in totalit{\"a}r-religi{\"o}sen L{\"a}ndern kennenzulernen und zu erfahren, inwieweit die Zensur das t{\"a}gliche Leben durchdrungen und beeinflusst hat -in der Kunst, der Literatur, den Medien usw. Ein Ph{\"a}nomen, das sogar die Privatsph{\"a}re des Individuums beeintr{\"a}chtigt.}, language = {de} } @masterthesis{Kilcher2023, type = {Bachelor Thesis}, author = {Kilcher, Mathias}, title = {Barrierefreies Klettern : ein System zur Inklusion sehbehinderter Menschen in den Klettersport}, publisher = {FH Aachen}, address = {Aachen}, school = {Fachhochschule Aachen}, pages = {135 Seiten}, year = {2023}, abstract = {Ziel des Projekts war die Entwicklung eines Systems, das es Menschen mit starker Sehbehinderung erm{\"o}glicht, Klettersport als ein Training f{\"u}r ihren K{\"o}rper und ihren Orientierungssinn nutzen zu k{\"o}nnen. Inklusion ist als gesellschaftliches Thema in den letzten Jahren stark in den Fokus ger{\"u}ckt. Dennoch ist es f{\"u}r Menschen mit Behinderung oft schwer, sozialen Anschluss zu finden. Dies wird zus{\"a}tzlich durch das mangelnde Angebot an inklusiven Freizeitaktivit{\"a}ten erschwert. Apollon erm{\"o}glicht Menschen mit starker Sehbehinderung die Orientierung w{\"a}hrend des Kletterns, indem es einerseits Informationen vermittelt, die normalerweise nur visuell wahrgenommen werden k{\"o}nnen und andererseits dabei hilft, sich besser an bereits gekletterte Routen zu erinnern. Das System setzt sich aus 3 Komponenten zusammen. Die Tritthilfen helfen der blinden Person dabei, auch kleine Tritte zu finden. Die taktilen Wegmarken stellen eine Art Checkpoint dar und helfen der blinden Person dabei, die Route in mehrere Abschnitte zu unterteilen. Gleichzeitig weisen sie darauf hin, welches Feature die kletternde Person erwartet. Die taktile Karte ist modular aufgebaut und setzt sich aus einer Legende und den Repr{\"a}sentanten der Wegmarken einer Route zusammen. Analog zu dem Betrachten der Route ist die blinde Person so vor dem Klettern in der Lage, Informationen {\"u}ber die Route zu erfahren.}, language = {de} } @masterthesis{Farjam2023, type = {Bachelor Thesis}, author = {Farjam, Ina}, title = {Farfilia : experimenteller Tanzfilm {\"u}ber eine Vater-Tochter-Beziehung}, publisher = {FH Aachen}, address = {Aachen}, pages = {61 Seiten}, year = {2023}, abstract = {Der experimentelle Tanzfilm „Farfilia" behandelt die Beziehung einer Tochter zu ihrem Vater. Beide Parteien funktionieren sehr unterschiedlich, denken, kommunizieren und leben in v{\"o}llig verschiedenen Welten. Es findet ein Konflikt zwischen den Generationen statt, zwischen zwei sehr gegens{\"a}tzlichen Pr{\"a}gungen und Charakteren. Die zwei Welten unterscheiden sich nicht nur in ihrer Visualit{\"a}t, sondern durch die in ihr lebenden und handelnden zwei Hauptprotagonist*innen, welches bildgestalterisch durch ein Zusammenspiel von Cinematographie, Choreographie und Setting ausgearbeitet und dargestellt wird. Durch die gemeinsame Wirkung vieler unterschiedlicher Gestaltungsmittel soll eine Geschichte erz{\"a}hlt werden, in der sich beide Welten aufeinander zu bewegen und am Ende Elemente der jeweils anderen Welt in sich aufnehmen und f{\"u}r die eigene Empfindung in der jeweiligen Umgebung adaptieren.}, language = {de} } @masterthesis{Leiwen2023, type = {Bachelor Thesis}, author = {Leiwen, Sophie}, title = {Steinreich : Mineralien des Siegerlands}, publisher = {FH Aachen}, address = {Aachen}, pages = {69 Seiten}, year = {2023}, abstract = {Der Aufbau und die Entstehung unseres Planeten sind untrennbar mit der Bildung von Gesteinen verbunden - diese setzen sich aus verschiedenen Mineralien zusammen. Sie sind in der Natur weit verbreitet und spielen eine entscheidende Rolle in unserem t{\"a}glichen Leben. Obwohl vielen Menschen der Nutzen von Bodensch{\"a}tzen bewusst ist, besteht ein geringes Wissen {\"u}ber deren Vorkommen und Relevanz. F{\"u}r die wirtschaftliche Entwicklung des Siegerlandes beispielsweise waren der Abbau und der Handel mit Mineralien von großer Bedeutung. Insbesondere der langj{\"a}hrige Abbau von Eisenerz legte den Grundstein f{\"u}r die gesamte Metallindustrie der Region. Die Publikation visualisiert eine umfangreiche Sammlung Siegerl{\"a}nder Mineralien und vermittelt ein grundlegendes Verst{\"a}ndnis von Mineralien.}, language = {de} } @masterthesis{Martinez2023, type = {Bachelor Thesis}, author = {Martinez, Mariana}, title = {The Taste of Memories : a recipe book of memories}, publisher = {FH Aachen}, address = {Aachen}, pages = {110 Seiten}, year = {2023}, abstract = {What does the word 'home' means and at what age do we give it meaning? Many of us grew up in one, in a home that our parents, grandparents, aunts, uncles and relatives shaped. Who, as we grew up, taught us about the world from their perspective as we interpreted and saw it for the first time and with it, its colors, its smells, its tastes, its sounds, its dances, and its languages. When we migrate, we take all that with us, like a piece of luggage that was stored in some corner inside a lung, or inside the memory in a heart's artery. And then you arrive in this new world, which we were told was the Old World, with other colors, other flavors, other words, in which yours no longer make sense. And you try to connect with all your senses, but, above all, we try to belong, because we belonged all our lives to something, to someone, to some place where we learned to be. When we migrate, without saying, we go through the grieve that comes with the beautiful discomfort of leaving everything we once knew. We mourn, because we can't go to lunch at our grandmas on Sundays, or have mom bring us soup when we are sick, or the Christmas meals and celebrations that we like so much, or that special dish that was made for us on our birthdays or on a family BBQ on a Sunday or a holiday. I wonder if emotions come inside us through the taste and respiratory track, if it is that we breathe life, and with that what we love finds its ways inside and finds its corner somewhere in the body. If what we have loved and what we have lived hides somewhere in our body, I doubtlessly think it came in through one of our senses, and in this attempt at my first illustrated book I'll share which, I think, are the senses through which at first instance part of what we perceive as cultural identity enters.}, language = {de} } @article{FalkenbergVossBottetal.2023, author = {Falkenberg, Fabian and Voß, Leonie and Bott, Michael and Bongaerts, Johannes and Siegert, Petra}, title = {New robust subtilisins from halotolerant and halophilic Bacillaceae}, series = {Applied Microbiology and Biotechnology}, volume = {107}, journal = {Applied Microbiology and Biotechnology}, publisher = {Springer Nature}, address = {Berlin}, issn = {1432-0614}, doi = {10.1007/s00253-023-12553-w}, pages = {3939 -- 3954}, year = {2023}, abstract = {The aim of the present study was the characterisation of three true subtilisins and one phylogenetically intermediate subtilisin from halotolerant and halophilic microorganisms. Considering the currently growing enzyme market for efficient and novel biocatalysts, data mining is a promising source for novel, as yet uncharacterised enzymes, especially from halophilic or halotolerant Bacillaceae, which offer great potential to meet industrial needs. Both halophilic bacteria Pontibacillus marinus DSM 16465ᵀ and Alkalibacillus haloalkaliphilus DSM 5271ᵀ and both halotolerant bacteria Metabacillus indicus DSM 16189 and Litchfieldia alkalitelluris DSM 16976ᵀ served as a source for the four new subtilisins SPPM, SPAH, SPMI and SPLA. The protease genes were cloned and expressed in Bacillus subtilis DB104. Purification to apparent homogeneity was achieved by ethanol precipitation, desalting and ion-exchange chromatography. Enzyme activity could be observed between pH 5.0-12.0 with an optimum for SPPM, SPMI and SPLA around pH 9.0 and for SPAH at pH 10.0. The optimal temperature for SPMI and SPLA was 70 °C and for SPPM and SPAH 55 °C and 50 °C, respectively. All proteases showed high stability towards 5\% (w/v) SDS and were active even at NaCl concentrations of 5 M. The four proteases demonstrate potential for future biotechnological applications.}, language = {en} } @inproceedings{ChircuCzarneckiFriedmannetal.2023, author = {Chircu, Alina and Czarnecki, Christian and Friedmann, Daniel and Pomaskow, Johanna and Sultanow, Eldar}, title = {Towards a Digital Twin of Society}, series = {Proceedings of the 56th Hawaii International Conference on System Sciences 2023}, booktitle = {Proceedings of the 56th Hawaii International Conference on System Sciences 2023}, publisher = {University of Hawai'i}, address = {Honolulu}, isbn = {978-0-9981331-6-4}, pages = {6748 -- 6757}, year = {2023}, abstract = {This paper describes the potential for developing a digital twin of society- a dynamic model that can be used to observe, analyze, and predict the evolution of various societal aspects. Such a digital twin can help governmental agencies and policy makers in interpreting trends, understanding challenges, and making decisions regarding investments or policies necessary to support societal development and ensure future prosperity. The paper reviews related work regarding the digital twin paradigm and its applications. The paper presents a motivating case study- an analysis of opportunities and challenges faced by the German federal employment agency, Bundesagentur f¨ur Arbeit (BA), proposes solutions using digital twins, and describes initial proofs of concept for such solutions.}, language = {en} } @book{Heuermann2023, author = {Heuermann, Holger}, title = {Hochfrequenztechnik. Komponenten und Mess-, Funk-, RFID- sowie Lokalisierungssysteme}, edition = {4}, publisher = {Springer Fachmedien}, address = {Wiesbaden}, isbn = {978-3-658-37825-7 (Print)}, pages = {XV, 453 Seiten}, year = {2023}, abstract = {Dieses Lehr- und Fachbuch vermittelt anschaulich die Grundlagen der HF-Technik, gibt konkrete Beschreibungen f{\"u}r den Entwurf von linearen Komponenten aus Bauteilen wie auch Leitungen f{\"u}r High-Speed- und HF-Schaltungen. Dem Leser wird vermittelt, wie Bauteile modelliert und Schaltungen synthetisiert und optimiert werden. Mit Hilfe frei verf{\"u}gbarer Simulationssoftware k{\"o}nnen GHz-Schaltungen selbst entwickelt werden. Viele {\"U}bungsbeispiele erm{\"o}glichen die Eigenkontrolle des Wissensstandes. Weiterhin werden komplexe nichtlineare Komponenten wie Hochfrequenzmischer, Oszillatoren und Synthesegeneratoren in ihrer Funktionalit{\"a}t dargestellt. Die neuen Mixed-Mode-Streuparameter sowie deren Leitungs- und Schaltungstechnik f{\"u}r Anwendungen der schnellen Digital- und der modernen HF-Technik sind ausf{\"u}hrlich beschrieben. Es wird auf Systeme f{\"u}r folgende Bereiche eingegangen: Streuparametermesstechnik, verschiedene Funktechniken, UHF-RFID und Lokalisierung- und Ortung. Dem Leser wird somit erm{\"o}glicht, komplexe GHz-Schaltungen insbesondere mit Halbleiter-, SMD- und LTCC-Schaltungen zu entwickeln.}, language = {de} } @article{HaegerWirgesTanzmannetal.2023, author = {Haeger, Gerrit and Wirges, Jessika and Tanzmann, Nicole and Oyen, Sven and Jolmes, Tristan and Jaeger, Karl-Erich and Sch{\"o}rken, Ulrich and Bongaerts, Johannes and Siegert, Petra}, title = {Chaperone assisted recombinant expression of a mycobacterial aminoacylase in Vibrio natriegens and Escherichia coli capable of N-lauroyl-L-amino acid synthesis}, series = {Microbial Cell Factories}, journal = {Microbial Cell Factories}, number = {22}, publisher = {Springer Nature}, issn = {1475-2859}, doi = {10.1186/s12934-023-02079-1}, pages = {Article number: 77 (2023)}, year = {2023}, abstract = {Background Aminoacylases are highly promising enzymes for the green synthesis of acyl-amino acids, potentially replacing the environmentally harmful Schotten-Baumann reaction. Long-chain acyl-amino acids can serve as strong surfactants and emulsifiers, with application in cosmetic industries. Heterologous expression of these enzymes, however, is often hampered, limiting their use in industrial processes. Results We identified a novel mycobacterial aminoacylase gene from Mycolicibacterium smegmatis MKD 8, cloned and expressed it in Escherichia coli and Vibrio natriegens using the T7 overexpression system. The recombinant enzyme was prone to aggregate as inclusion bodies, and while V. natriegens Vmax™ could produce soluble aminoacylase upon induction with isopropyl β-d-1-thiogalactopyranoside (IPTG), E. coli BL21 (DE3) needed autoinduction with lactose to produce soluble recombinant protein. We successfully conducted a chaperone co-expression study in both organisms to further enhance aminoacylase production and found that overexpression of chaperones GroEL/S enhanced aminoacylase activity in the cell-free extract 1.8-fold in V. natriegens and E. coli. Eventually, E. coli ArcticExpress™ (DE3), which co-expresses cold-adapted chaperonins Cpn60/10 from Oleispira antarctica, cultivated at 12 °C, rendered the most suitable expression system for this aminoacylase and exhibited twice the aminoacylase activity in the cell-free extract compared to E. coli BL21 (DE3) with GroEL/S co-expression at 20 °C. The purified aminoacylase was characterized based on hydrolytic activities, being most stable and active at pH 7.0, with a maximum activity at 70 °C, and stability at 40 °C and pH 7.0 for 5 days. The aminoacylase strongly prefers short-chain acyl-amino acids with smaller, hydrophobic amino acid residues. Several long-chain amino acids were fairly accepted in hydrolysis as well, especially N-lauroyl-L-methionine. To initially evaluate the relevance of this aminoacylase for the synthesis of N-acyl-amino acids, we demonstrated that lauroyl-methionine can be synthesized from lauric acid and methionine in an aqueous system. Conclusion Our results suggest that the recombinant enzyme is well suited for synthesis reactions and will thus be further investigated.}, language = {en} } @masterthesis{Ferraioli2023, type = {Bachelor Thesis}, author = {Ferraioli, Luigi}, title = {Validierung einer Simulationsumgebung f{\"u}r Umfeldsensorik von Schienenfahrzeugen}, publisher = {FH Aachen}, address = {Aachen}, school = {Fachhochschule Aachen}, pages = {49 Seiten}, year = {2023}, abstract = {Diese Bachelorarbeit befasst sich mit der digitalen Nachbildung eines Testgel{\"a}ndes sowie eines Schienenfahrzeugs in der Simulationsumgebung Gazebo. Der Schwerpunkt liegt auf der pr{\"a}zisen Abbildung der Umfeldsensorik anhand eines realen Schienenfahrzeuges. Ziel ist die Erzeugung {\"a}quivalenter Messdaten der Simulationsumgebung und des realen Schienenfahrzeuges unter gleichen Einsatzbedingungen. Dazu werden unterschiedliche Verfahren eingesetzt, um die Parameter der einzelnen Sensorik so zu konfigurieren, dass die Messergebnisse mit den Messdaten der realen Sensorik konvergieren. Die Ergebnisse der Messdaten zeigen, dass obwohl die Simulationsumgebung einige physikalische Materialeigenschaften nicht ber{\"u}cksichtigt, eine pr{\"a}zise Abbildung der Sensorik und geometrischen Strukturen des Testgel{\"a}ndes m{\"o}glich ist. Dar{\"u}ber hinaus erm{\"o}glicht die Kombination von Gazebo und ROS2 Integrationstests und die Entwicklung von Softwareanwendungen sowohl in der Simulation als auch auf dem realen Schienenfahrzeug. Eine realit{\"a}tsnahe und reproduzierbare Auswertung der Sensormessdaten der Simulationsumgebung f{\"u}r Schienenfahrzeuge ist somit realisierbar.}, language = {de} } @article{RhodenBallGrajewskietal.2023, author = {Rhoden, Imke and Ball, Christopher Stephen and Grajewski, Matthias and Kuckshinrich, Wilhelm}, title = {Reverse engineering of stakeholder preferences - A multi-criteria assessment of the German passenger car sector}, series = {Renewable and Sustainable Energy Reviews}, volume = {181}, journal = {Renewable and Sustainable Energy Reviews}, number = {July 2023}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1364-0321}, doi = {10.1016/j.rser.2023.113352}, pages = {Article number: 113352}, year = {2023}, abstract = {Germany is a frontrunner in setting frameworks for the transition to a low-carbon system. The mobility sector plays a significant role in this shift, affecting different people and groups on multiple levels. Without acceptance from these stakeholders, emission targets are out of reach. This research analyzes how the heterogeneous preferences of various stakeholders align with the transformation of the mobility sector, looking at the extent to which the German transformation paths are supported and where stakeholders are located. Under the research objective of comparing stakeholders' preferences to identify which car segments require additional support for a successful climate transition, a status quo of stakeholders and car performance criteria is the foundation for the analysis. Stakeholders' hidden preferences hinder the derivation of criteria weightings from stakeholders; therefore, a ranking from observed preferences is used. This study's inverse multi-criteria decision analysis means that weightings can be predicted and used together with a recalibrated performance matrix to explore future preferences toward car segments. Results show that stakeholders prefer medium-sized cars, with the trend pointing towards the increased potential for alternative propulsion technologies and electrified vehicles. These insights can guide the improved targeting of policy supporting the energy and mobility transformation. Additionally, the method proposed in this work can fully handle subjective approaches while incorporating a priori information. A software implementation of the proposed method completes this work and is made publicly available.}, language = {en} } @article{SavitskayaZhantlessovaKistaubayevaetal.2023, author = {Savitskaya, Irina and Zhantlessova, Sirina and Kistaubayeva, Aida and Ignatova, Ludmila and Shokatayeva, Dina and Sinyavsky, Yuriy and Kushugulova, Almagul and Digel, Ilya}, title = {Prebiotic cellulose-pullulan matrix as a "vehicle" for probiotic biofilm delivery to the host large intestine}, series = {Polymers}, journal = {Polymers}, number = {16(1)}, publisher = {MDPI}, address = {Basel}, doi = {10.3390/polym16010030}, pages = {Artikel 30}, year = {2023}, abstract = {This study describes the development of a new combined polysaccharide-matrix-based technology for the immobilization of Lactobacillus rhamnosus GG (LGG) bacteria in biofilm form. The new composition allows for delivering the bacteria to the digestive tract in a manner that improves their robustness compared with planktonic cells and released biofilm cells. Granules consisting of a polysaccharide matrix with probiotic biofilms (PMPB) with high cell density (>9 log CFU/g) were obtained by immobilization in the optimized nutrient medium. Successful probiotic loading was confirmed by fluorescence microscopy and scanning electron microscopy. The developed prebiotic polysaccharide matrix significantly enhanced LGG viability under acidic (pH 2.0) and bile salt (0.3\%) stress conditions. Enzymatic extract of feces, mimicking colon fluid in terms of cellulase activity, was used to evaluate the intestinal release of probiotics. PMPB granules showed the ability to gradually release a large number of viable LGG cells in the model colon fluid. In vivo, the oral administration of PMPB granules in rats resulted in the successful release of probiotics in the colon environment. The biofilm-forming incubation method of immobilization on a complex polysaccharide matrix tested in this study has shown high efficacy and promising potential for the development of innovative biotechnologies.}, language = {en} } @incollection{EngelmannBaumann2023, author = {Engelmann, Ulrich M. and Baumann, Martin}, title = {Moderationsexpertise f{\"u}r QMBs - die Methoden}, series = {Qualit{\"a}tsmanagement im Gesundheitswesen}, booktitle = {Qualit{\"a}tsmanagement im Gesundheitswesen}, editor = {Herbig, Nicola and Poppelreuter, Stefan}, edition = {60. Update}, publisher = {T{\"U}V-Verlag}, address = {K{\"o}ln}, isbn = {978-3-8249-0714-4}, pages = {Kapitel 10815}, year = {2023}, abstract = {Damit Sie als Moderator effektiv und professionell moderieren k{\"o}nnen, sollten Sie die entsprechenden Methoden kennen. Mit den richtigen Methoden k{\"o}nnen Sie Diskussionen leiten, Konflikte l{\"o}sen, die Teilnehmer motivieren und daf{\"u}r sorgen, dass die Ziele der Veranstaltung erreicht werden. Außerdem helfen sie Ihnen, eine positive Atmosph{\"a}re zu schaffen und das Interesse der Teilnehmer zu halten. In diesem zweiten Beitrag der mehrteiligen Serie lernen Sie die grunds{\"a}tzlichen Methoden kennen, um erfolgreiche Teamsitzungen, Arbeitsgruppentreffen, Kick-offs und Meetings durchzuf{\"u}hren.}, language = {de} } @article{Timme2023, author = {Timme, Michael}, title = {Die Erbringung einer Leistung in der irrigen Vorstellung einer Bestellung (Zu BGH, MDR 2023, 1439)}, series = {Monatsschrift f{\"u}r Deutsches Recht}, volume = {77}, journal = {Monatsschrift f{\"u}r Deutsches Recht}, number = {24}, publisher = {Verlag Dr. Otto Schmidt}, address = {K{\"o}ln}, issn = {2194-4202 (online)}, doi = {10.9785/mdtr-2023-772402}, pages = {R293 -- R296}, year = {2023}, language = {de} }