@article{FassbenderSchmittSchoeningetal.2000,
  author    = {Faßbender, F. and Schmitt, G. and Sch{\"o}ning, Michael Josef and L{\"u}th, H. and Buß, G. and Schultze, J. W.},
  title     = {Optimization of passivation layers for corrosion protection of silicon-based microelectrode arrays},
  series = {Sensors and Actuators B. 68 (2000), H. 1-3},
  journal   = {Sensors and Actuators B. 68 (2000), H. 1-3},
  isbn      = {0925-4005},
  pages     = {128 -- 133},
  year      = {2000},
  language  = {en}
}
@article{DegeringEggertPulsetal.2010,
  author    = {Degering, Christian and Eggert, Thorsten and Puls, Michael and Bongaerts, Johannes and Evers, Stefan and Maurer, Karl-Heinz and Jaeger, Karl-Erich},
  title     = {Optimization of protease secretion in Bacillus subtilis and Bacillus licheniformis by screening of homologous and herologous signal peptides},
  series = {Applied and environmental microbiology},
  volume    = {76},
  journal   = {Applied and environmental microbiology},
  number    = {19},
  publisher = {American Society for Microbiology},
  address   = {Washington, DC},
  issn      = {1098-5336 (E-Journal); 0003-6919 (Print); 0099-2240 (Print)},
  doi       = {10.1128/AEM.01146-10},
  pages     = {6370 -- 6378},
  year      = {2010},
  abstract  = {Bacillus subtilis and Bacillus licheniformis are widely used for the large-scale industrial production of proteins. These strains can efficiently secrete proteins into the culture medium using the general secretion (Sec) pathway. A characteristic feature of all secreted proteins is their N-terminal signal peptides, which are recognized by the secretion machinery. Here, we have studied the production of an industrially important secreted protease, namely, subtilisin BPN′ from Bacillus amyloliquefaciens. One hundred seventy-three signal peptides originating from B. subtilis and 220 signal peptides from the B. licheniformis type strain were fused to this secretion target and expressed in B. subtilis, and the resulting library was analyzed by high-throughput screening for extracellular proteolytic activity. We have identified a number of signal peptides originating from both organisms which produced significantly increased yield of the secreted protease. Interestingly, we observed that levels of extracellular protease were improved not only in B. subtilis, which was used as the screening host, but also in two different B. licheniformis strains. To date, it is impossible to predict which signal peptide will result in better secretion and thus an improved yield of a given extracellular target protein. Our data show that screening a library consisting of homologous and heterologous signal peptides fused to a target protein can identify more-effective signal peptides, resulting in improved protein export not only in the original screening host but also in different production strains.},
  language  = {en}
}
@article{HoffstadtNikolauszKrafftetal.2024,
  author    = {Hoffstadt, Kevin and Nikolausz, Marcell and Krafft, Simone and Bonatelli, Maria and Kumar, Vivekanantha and Harms, Hauke and Kuperjans, Isabel},
  title     = {Optimization of the ex situ biomethanation of hydrogen and carbon dioxide in a novel meandering plug flow reactor: start-up phase and flexible operation},
  series = {Bioengineering},
  volume    = {11},
  journal   = {Bioengineering},
  number    = {2},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2306-5354},
  doi       = {10.3390/bioengineering11020165},
  pages     = {18 Seiten},
  year      = {2024},
  language  = {en}
}
@article{JungMuellerStaat2019,
  author    = {Jung, Alexander and M{\"u}ller, Wolfram and Staat, Manfred},
  title     = {Optimization of the flight technique in ski jumping: the influence of wind},
  number    = {Early view},
  publisher = {Elsevier},
  address   = {Amsterdam},
  doi       = {10.1016/j.jbiomech.2019.03.023},
  year      = {2019},
  language  = {en}
}
@article{AlexopoulosBreitbachHoffschmidtetal.2008,
  author    = {Alexopoulos, Spiros and Breitbach, Gerd and Hoffschmidt, Bernhard and Stobbe, P.},
  title     = {Optimization of the geometry of porous SiC ceramic filtering modules using numerical methods},
  series = {Developments in porous, biological and geopolymer ceramics : a collection of papers presented at the 31st International Conference on Advanced Ceramics and Composites, January 21 - 26, 2007, Daytona Beach, Florida ; [papers presented at the Symposium on Porous Ceramics: Novel Developments and Applications] / ed.: Manuel Brito ... Vol. ed.: Jonathan Salem ... The American Ceramics Society},
  journal   = {Developments in porous, biological and geopolymer ceramics : a collection of papers presented at the 31st International Conference on Advanced Ceramics and Composites, January 21 - 26, 2007, Daytona Beach, Florida ; [papers presented at the Symposium on Porous Ceramics: Novel Developments and Applications] / ed.: Manuel Brito ... Vol. ed.: Jonathan Salem ... The American Ceramics Society},
  publisher = {Wiley},
  address   = {Hoboken, NJ},
  isbn      = {9780470196403},
  pages     = {95 -- 104},
  year      = {2008},
  language  = {en}
}
@article{ArreolaMaetzkowDuranetal.2016,
  author    = {Arreola, Julio and M{\"a}tzkow, Malte and Dur{\´a}n, Marlena Palomar and Greeff, Anton and Keusgen, Michael and Sch{\"o}ning, Michael Josef},
  title     = {Optimization of the immobilization of bacterial spores on glass substrates with organosilanes},
  series = {Physica status solidi (A) : Applications and materials science},
  volume    = {213},
  journal   = {Physica status solidi (A) : Applications and materials science},
  number    = {6},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {1862-6319},
  doi       = {10.1002/pssa.201532914},
  pages     = {1463 -- 1470},
  year      = {2016},
  abstract  = {Spores can be immobilized on biosensors to function as sensitive recognition elements. However, the immobilization can affect the sensitivity and reproducibility of the sensor signal. In this work, three different immobilization strategies with organosilanes were optimized and characterized to immobilize Bacillus atrophaeus spores on glass substrates. Five different silanization parameters were investigated: nature of the solvent, concentration of the silane, silanization time, curing process, and silanization temperature. The resulting silane layers were resistant to a buffer solution (e.g., Ringer solution) with a polysorbate (e.g., Tween®80) and sonication.},
  language  = {en}
}
@article{Dachwald2005,
  author    = {Dachwald, Bernd},
  title     = {Optimization of very-low-thrust trajectories using evolutionary neurocontrol},
  series = {Acta Astronautica},
  volume    = {57},
  journal   = {Acta Astronautica},
  number    = {2-8},
  publisher = {Elsevier},
  address   = {Amsterdam [u.a.]},
  isbn      = {1879-2030},
  pages     = {175 -- 185},
  year      = {2005},
  abstract  = {Searching optimal interplanetary trajectories for low-thrust spacecraft is usually a difficult and time-consuming task that involves much experience and expert knowledge in astrodynamics and optimal control theory. This is because the convergence behavior of traditional local optimizers, which are based on numerical optimal control methods, depends on an adequate initial guess, which is often hard to find, especially for very-low-thrust trajectories that necessitate many revolutions around the sun. The obtained solutions are typically close to the initial guess that is rarely close to the (unknown) global optimum. Within this paper, trajectory optimization problems are attacked from the perspective of artificial intelligence and machine learning. Inspired by natural archetypes, a smart global method for low-thrust trajectory optimization is proposed that fuses artificial neural networks and evolutionary algorithms into so-called evolutionary neurocontrollers. This novel method runs without an initial guess and does not require the attendance of an expert in astrodynamics and optimal control theory. This paper details how evolutionary neurocontrol works and how it could be implemented. The performance of the method is assessed for three different interplanetary missions with a thrust to mass ratio <0.15mN/kg (solar sail and nuclear electric).},
  language  = {en}
}
@article{Dachwald2005,
  author    = {Dachwald, Bernd},
  title     = {Optimization of very-low-thrust trajectories using evolutionary neurocontrol},
  series = {Acta Astronautica. 57 (2005), H. 2-8},
  journal   = {Acta Astronautica. 57 (2005), H. 2-8},
  isbn      = {0094-5765},
  pages     = {175 -- 185},
  year      = {2005},
  language  = {en}
}
@article{BankOrzadaSmitsetal.2015,
  author    = {Bank, Bart L. van de and Orzada, Stephan and Smits, Frits and Lagemaat, Miriam W. and Rodgers, Christopher T. and Bitz, Andreas and Scheenen, Tom W. J.},
  title     = {Optimized (31) P MRS in the human brain at 7 T with a dedicated RF coil setup},
  series = {NMR in Biomedicine},
  volume    = {28},
  journal   = {NMR in Biomedicine},
  number    = {11},
  publisher = {Wiley},
  address   = {Weinheim},
  issn      = {1099-1492},
  doi       = {10.1002/nbm.3422},
  pages     = {1570 -- 1578},
  year      = {2015},
  language  = {en}
}
@article{Esch1991,
  author    = {Esch, Thomas},
  title     = {Optimized design of the lubrication system of modern combustion engines. Verbesserte Ausf{\"u}hrung von Schmierungssystemen bei modernen Verbrennungsmotoren},
  isbn      = {0148-7191},
  doi       = {10.4271/912407},
  pages     = {1 -- 11},
  year      = {1991},
  language  = {en}
}
@article{HugenrothBorchardtRitteretal.2021,
  author    = {Hugenroth, Kristin and Borchardt, Ralf and Ritter, Philine and Groß‑Hardt, Sascha and Meyns, Bart and Verbelen, Tom and Steinseifer, Ulrich and Kaufmann, Tim A. S. and Engelmann, Ulrich M.},
  title     = {Optimizing cerebral perfusion and hemodynamics during cardiopulmonary bypass through cannula design combining in silico, in vitro and in vivo input},
  series = {Scientific Reports},
  volume    = {11},
  journal   = {Scientific Reports},
  number    = {Art. No. 16800},
  publisher = {Springer},
  address   = {Berlin},
  issn      = {2045-2322},
  doi       = {10.1038/s41598-021-96397-2},
  pages     = {1 -- 12},
  year      = {2021},
  abstract  = {Cardiopulmonary bypass (CPB) is a standard technique for cardiac surgery, but comes with the risk of severe neurological complications (e.g. stroke) caused by embolisms and/or reduced cerebral perfusion. We report on an aortic cannula prototype design (optiCAN) with helical outflow and jet-splitting dispersion tip that could reduce the risk of embolic events and restores cerebral perfusion to 97.5\% of physiological flow during CPB in vivo, whereas a commercial curved-tip cannula yields 74.6\%. In further in vitro comparison, pressure loss and hemolysis parameters of optiCAN remain unaffected. Results are reproducibly confirmed in silico for an exemplary human aortic anatomy via computational fluid dynamics (CFD) simulations. Based on CFD simulations, we firstly show that optiCAN design improves aortic root washout, which reduces the risk of thromboembolism. Secondly, we identify regions of the aortic intima with increased risk of plaque release by correlating areas of enhanced plaque growth and high wall shear stresses (WSS). From this we propose another easy-to-manufacture cannula design (opti2CAN) that decreases areas burdened by high WSS, while preserving physiological cerebral flow and favorable hemodynamics. With this novel cannula design, we propose a cannulation option to reduce neurological complications and the prevalence of stroke in high-risk patients after CPB.},
  language  = {en}
}
@article{DachwaldCarnelliVasile2007,
  author    = {Dachwald, Bernd and Carnelli, I. and Vasile, M.},
  title     = {Optimizing low-thrust gravity assist interplanetary trajectories using evolutionary neurocontrollers / I. Carnelli ; B. Dachwald ; M. Vasile},
  series = {IEEE Congress on Evolutionary Computation, 2007 : CEC 2007 ; 25 - 28 September 2007, Singapore},
  journal   = {IEEE Congress on Evolutionary Computation, 2007 : CEC 2007 ; 25 - 28 September 2007, Singapore},
  publisher = {IEEE Service Center},
  address   = {Piscataway, NJ},
  isbn      = {978-1-424-41339-3},
  pages     = {965 -- 972},
  year      = {2007},
  language  = {en}
}
@article{EngelsDoege1998,
  author    = {Engels, Elmar and Doege, E.},
  title     = {Optimizing the number of strokes for punching machines using a fuzzy controlled electrohydraulic damping system / Doege, E. ; Engels, E.},
  series = {ICME 98, CIRP International Seminar on Intelligent Computation in Manufacturing Engineering, Proceedings, Capri, IT, Jul 1-3, 1998},
  journal   = {ICME 98, CIRP International Seminar on Intelligent Computation in Manufacturing Engineering, Proceedings, Capri, IT, Jul 1-3, 1998},
  address   = {Capri},
  pages     = {471 -- 478},
  year      = {1998},
  language  = {en}
}
@article{Benkner1998,
  author    = {Benkner, Thorsten},
  title     = {Optimum Transmission Power in High Capacity Umbrella Cell Systems},
  series = {Multiaccess, mobility and teletraffic : advances in wireless networks ; [proceedings of the Third Workshop on Multiaccess, Mobility and Teletraffic for Personal Communications held in December 1997 in Melbourne, Australia] / ed. by David Everitt ...},
  journal   = {Multiaccess, mobility and teletraffic : advances in wireless networks ; [proceedings of the Third Workshop on Multiaccess, Mobility and Teletraffic for Personal Communications held in December 1997 in Melbourne, Australia] / ed. by David Everitt ...},
  publisher = {Kluwer},
  address   = {Boston, Mass. [u.a.]},
  isbn      = {0-7923-8091-6},
  pages     = {221 -- 232},
  year      = {1998},
  language  = {en}
}
@article{FerreinBoehnstedtLakemeyer2007,
  author    = {Ferrein, Alexander and B{\"o}hnstedt, Lutz and Lakemeyer, Gerhard},
  title     = {Options in readylog reloaded -- generating decision-theoretic plan libraries in golog / B{\"o}hnstedt, Lutz ; Ferrein, Alexander ; Lakemeyer, Gerhard},
  series = {KI 2007: advances in artificial intelligence : 30th Annual German Conference on AI, KI 2007, Osnabr{\"u}ck, Germany, September 10 - 13, 2007 ; proceedings},
  journal   = {KI 2007: advances in artificial intelligence : 30th Annual German Conference on AI, KI 2007, Osnabr{\"u}ck, Germany, September 10 - 13, 2007 ; proceedings},
  publisher = {Springer},
  address   = {Berlin},
  isbn      = {978-3-540-74564-8},
  pages     = {352 -- 366},
  year      = {2007},
  language  = {en}
}
@article{PitaKraemerZouhetal.2008,
  author    = {Pita, Marcos and Kr{\"a}mer, Melina and Zouh, Jian and Poghossian, Arshak and Sch{\"o}ning, Michael Josef and Fernandez, Victor M. and Katz, Evgeny},
  title     = {Optoelectronic Properties of Nanostructured Ensembles Controlled by Biomolecular Logic Systems},
  series = {ACS Nano. 10 (2008), H. 2},
  journal   = {ACS Nano. 10 (2008), H. 2},
  isbn      = {1936-086X},
  pages     = {2160 -- 2166},
  year      = {2008},
  language  = {en}
}
@article{SadykovDigelTemizArtmannetal.2009,
  author    = {Sadykov, Rustam and Digel, Ilya and Temiz Artmann, Ayseg{\"u}l and Porst, Dariusz and Linder, Peter and Kayser, Peter and Artmann, Gerhard and Savitskaya, Irina and Zhubanova, Azhar},
  title     = {Oral lead exposure induces dysbacteriosis in rats},
  series = {Journal of Occupational Health. 51 (2009) (2009), H. 1},
  journal   = {Journal of Occupational Health. 51 (2009) (2009), H. 1},
  isbn      = {1348-9585},
  pages     = {64 -- 73},
  year      = {2009},
  language  = {en}
}
@article{PennerUsherovichNiedermeieretal.2022,
  author    = {Penner, Crystal and Usherovich, Samuel and Niedermeier, Jana and B{\´e}langer-Champagne, Camille and Trinczek, Michael and Paulßen, Elisabeth and Hoehr, Cornelia},
  title     = {Organic Scintillator-Fibre Sensors for Proton Therapy Dosimetry: SCSF-3HF and EJ-260},
  series = {electronics},
  volume    = {12},
  journal   = {electronics},
  number    = {1},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2079-9292},
  doi       = {10.3390/electronics12010011},
  pages     = {12 Seiten},
  year      = {2022},
  abstract  = {In proton therapy, the dose from secondary neutrons to the patient can contribute to side effects and the creation of secondary cancer. A simple and fast detection system to distinguish between dose from protons and neutrons both in pretreatment verification as well as potentially in vivo monitoring is needed to minimize dose from secondary neutrons. Two 3 mm long, 1 mm diameter organic scintillators were tested for candidacy to be used in a proton-neutron discrimination detector. The SCSF-3HF (1500) scintillating fibre (Kuraray Co. Chiyoda-ku, Tokyo, Japan) and EJ-260 plastic scintillator (Eljen Technology, Sweetwater, TX, USA) were irradiated at the TRIUMF Neutron Facility and the Proton Therapy Research Centre. In the proton beam, we compared the raw Bragg peak and spread-out Bragg peak response to the industry standard Markus chamber detector. Both scintillator sensors exhibited quenching at high LET in the Bragg peak, presenting a peak-to-entrance ratio of 2.59 for the EJ-260 and 2.63 for the SCSF-3HF fibre, compared to 3.70 for the Markus chamber. The SCSF-3HF sensor demonstrated 1.3 times the sensitivity to protons and 3 times the sensitivity to neutrons as compared to the EJ-260 sensor. Combined with our equations relating neutron and proton contributions to dose during proton irradiations, and the application of Birks' quenching correction, these fibres provide valid candidates for inexpensive and replicable proton-neutron discrimination detectors},
  language  = {en}
}
@article{ThielemannBock1994,
  author    = {Thielemann, Frank and Bock, J{\"u}rgen},
  title     = {Organization and management of German-Russian joint ventures. Bock, J{\"u}rgen; Thielemann, Frank},
  series = {International journal of technology management. 9 (1994), H. 8},
  journal   = {International journal of technology management. 9 (1994), H. 8},
  isbn      = {0267-5730},
  pages     = {864 -- 879},
  year      = {1994},
  language  = {en}
}
@article{EilmanndeVriesdenOudenetal.2013,
  author    = {Eilmann, Britta and de Vries, Sven M. G. and den Ouden, Jan and Mohren, Godefridus M. J. and Sauren, Pascal and Sass-Klaassen, Ute G. W.},
  title     = {Origin matters! Difference in drought tolerance and productivity of coastal Douglas-fir (Pseudotsuga menziesii (Mirb.)) provenances},
  series = {Forest Ecology and Management},
  volume    = {2013},
  journal   = {Forest Ecology and Management},
  number    = {302},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1872-7042 (Online)},
  doi       = {doi:10.1016/j.foreco.2013.03.031},
  pages     = {133 -- 143},
  year      = {2013},
  language  = {en}
}