@article{EilmannRigling2012, author = {Eilmann, Britta and Rigling, Andreas}, title = {Tree-growth analyses to estimate tree species' drought tolerance}, series = {Tree Physiology}, volume = {32}, journal = {Tree Physiology}, number = {2}, editor = {Abrams, Marc}, publisher = {Oxford University Press}, address = {Oxford}, issn = {0829-318X (Print)}, doi = {10.1093/treephys/tps004}, pages = {178 -- 187}, year = {2012}, abstract = {Climate change is challenging forestry management and practices. Among other things, tree species with the ability to cope with more extreme climate conditions have to be identified. However, while environmental factors may severely limit tree growth or even cause tree death, assessing a tree species' potential for surviving future aggravated environmental conditions is rather demanding. The aim of this study was to find a tree-ring-based method suitable for identifying very drought-tolerant species, particularly potential substitute species for Scots pine (Pinus sylvestris L.) in Valais. In this inner-Alpine valley, Scots pine used to be the dominating species for dry forests, but today it suffers from high drought-induced mortality. We investigate the growth response of two native tree species, Scots pine and European larch (Larix decidua Mill.), and two non-native species, black pine (Pinus nigra Arnold) and Douglas fir (Pseudotsuga menziesii Mirb. var. menziesii), to drought. This involved analysing how the radial increment of these species responded to increasing water shortage (abandonment of irrigation) and to increasingly frequent drought years. Black pine and Douglas fir are able to cope with drought better than Scots pine and larch, as they show relatively high radial growth even after irrigation has been stopped and a plastic growth response to drought years. European larch does not seem to be able to cope with these dry conditions as it lacks the ability to recover from drought years. The analysis of trees' short-term response to extreme climate events seems to be the most promising and suitable method for detecting how tolerant a tree species is towards drought. However, combining all the methods used in this study provides a complete picture of how water shortage could limit species.}, language = {en} } @article{BronderJessingPoghossianetal.2018, author = {Bronder, Thomas and Jessing, Max P. and Poghossian, Arshak and Keusgen, Michael and Sch{\"o}ning, Michael Josef}, title = {Detection of PCR-Amplified Tuberculosis DNA Fragments with Polyelectrolyte-Modified Field-Effect Sensors}, series = {Analytical Chemistry}, volume = {90}, journal = {Analytical Chemistry}, number = {12}, publisher = {ACS Publications}, address = {Washington, DC}, issn = {0003-2700}, doi = {10.1021/acs.analchem.8b01807}, pages = {7747 -- 7753}, year = {2018}, abstract = {Field-effect-based electrolyte-insulator-semiconductor (EIS) sensors were modified with a bilayer of positively charged weak polyelectrolyte (poly(allylamine hydrochloride) (PAH)) and probe single-stranded DNA (ssDNA) and are used for the detection of complementary single-stranded target DNA (cDNA) in different test solutions. The sensing mechanism is based on the detection of the intrinsic molecular charge of target cDNA molecules after the hybridization event between cDNA and immobilized probe ssDNA. The test solutions contain synthetic cDNA oligonucleotides (with a sequence of tuberculosis mycobacteria genome) or PCR-amplified DNA (which origins from a template DNA strand that has been extracted from Mycobacterium avium paratuberculosis-spiked human sputum samples), respectively. Sensor responses up to 41 mV have been measured for the test solutions with DNA, while only small signals of ∼5 mV were detected for solutions without DNA. The lower detection limit of the EIS sensors was ∼0.3 nM, and the sensitivity was ∼7.2 mV/decade. Fluorescence experiments using SybrGreen I fluorescence dye support the electrochemical results.}, language = {en} } @article{BerndtKlostermeyerZahn1972, author = {Berndt, Heinz and Klostermeyer, Henning and Zahn, Helmut}, title = {Zur Synthese monomerer cyclischer Cystinpeptidderivate, I : Synthese der Sequenz A 6-9 des Schafinsulins als Cyclocystinylderivat}, series = {Justus Liebigs Annalen der Chemie}, volume = {759}, journal = {Justus Liebigs Annalen der Chemie}, number = {1}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1099-0690}, doi = {10.1002/jlac.19727590109}, pages = {114 -- 120}, year = {1972}, abstract = {Es wird die Synthese der Sequenz A 6-9 des Schafinsulins in der gesch{\"u}tzten Form Boc-Cys-Cys-Ala-Gly-OBuᵗ (5) sowie das Verhalten dieses monomeren cyclischen Cystinpeptidderivates gegen{\"u}ber den in der Peptidchemie gebr{\"a}uchlichen Reagenzien Bortrifluorid/Eisessig, Tri{\"a}thylamin und Hydrazinhydrat beschrieben.}, language = {de} } @article{AnikFrohberg1984, author = {Anik, Sabri and Frohberg, Martin G.}, title = {Thermodynamics and solubility of oxygen in liquid copper-lead alloys at 1200°C from E.M.F. measurements}, series = {Berichte der Bunsengesellschaft f{\"u}r physikalische Chemie}, volume = {88}, journal = {Berichte der Bunsengesellschaft f{\"u}r physikalische Chemie}, number = {8}, issn = {0940-483X}, pages = {707 -- 710}, year = {1984}, language = {en} } @article{GenzKingWahle1992, author = {Genz, M. and King, H. and Wahle, Michael}, title = {Mikrozellige Polyurethan-Elastomere als Federelement in Automobilanwendungen}, series = {Automobiltechnische Zeitschrift ; ATZ}, volume = {94}, journal = {Automobiltechnische Zeitschrift ; ATZ}, number = {10}, issn = {0001-2785}, pages = {512 -- 520}, year = {1992}, language = {de} } @article{AnikTopuzTuncel1992, author = {Anik, Sabri and Topuz, A. and Tuncel, H. S.}, title = {Einfluß der Parameter beim Diffusionsschweißen der St{\"a}hle X210Cr12 mit 25 CrMo4 auf die Ausbildung der Bindezone}, series = {Schweißen und Schneiden : Fachzeitschrift f{\"u}r Schweißen und verwandte Verfahren}, volume = {44}, journal = {Schweißen und Schneiden : Fachzeitschrift f{\"u}r Schweißen und verwandte Verfahren}, number = {2}, issn = {0036}, pages = {97 -- 100}, year = {1992}, language = {de} } @article{WillmsBeerFroehlkeetal.1993, author = {Willms, Herbert and Beer, Stefan and Fr{\"o}hlke, K. and Haidn, O.J.}, title = {Regelung eines Wasserstoff-/Sauerstoff-Dampferzeugers mit Hilfe eines modifizierten Zirkondioxid-Sensors}, year = {1993}, language = {de} } @article{Sillius2014, author = {Sillius, Sarah}, title = {„Viele machen gutes Marketing, ohne es zu wissen" : zwei Experten von FH [Prof. Dr. Gert Hoepner] und RWTH Aachen [Prof. Dr. Daniel Mentzel] erkl{\"a}ren, wie Unternehmen ihre Zielgruppe besser erreichen}, series = {Wirtschaftliche Nachrichten : das Magazin f{\"u}r Unternehmen / Industrie- und Handelskammer Aachen}, volume = {2014}, journal = {Wirtschaftliche Nachrichten : das Magazin f{\"u}r Unternehmen / Industrie- und Handelskammer Aachen}, number = {3}, publisher = {IHK Aachen}, address = {Aachen}, pages = {16 -- 18}, year = {2014}, language = {de} } @article{ArtmannGrebeHomrighausenetal.1988, author = {Artmann, Gerhard and Grebe, R. and Homrighausen, A. and Wolff, H. and Teitel, P. and Schmid-Sch{\"o}nbein, H.}, title = {Response of normal and diabetic erythrocytes to membrane deformation by chemical and mechanical forces. Artmann, Gerhard Michael; Grebe, R.; Homrighausen, A.; Wolff, H.; Teitel, P.; Schmid-Sch{\"o}nbein, H.}, series = {12. Jahrestagung der Gesellschaft f{\"u}r Mikrozirkulation}, journal = {12. Jahrestagung der Gesellschaft f{\"u}r Mikrozirkulation}, publisher = {Karger [u.a.]}, address = {Basel [u.a.]}, pages = {196 -- 200}, year = {1988}, language = {en} } @article{JungMuellerStaat2019, author = {Jung, Alexander and M{\"u}ller, Wolfram and Staat, Manfred}, title = {Optimization of the flight technique in ski jumping: the influence of wind}, number = {Early view}, publisher = {Elsevier}, address = {Amsterdam}, doi = {10.1016/j.jbiomech.2019.03.023}, year = {2019}, language = {en} } @article{Raatschen2003, author = {Raatschen, Hans-J{\"u}rgen}, title = {Ingenieurstudium Hundert Jahre : von der K{\"o}niglichen H{\"o}heren Maschinenbauschule Aachen zu den Ingenieurfachbereichen der Fachhochschule}, series = {Fachblatt}, volume = {2003}, journal = {Fachblatt}, number = {1}, organization = {FH Aachen, University of Applied Sciences}, pages = {28 -- 29}, year = {2003}, language = {de} } @article{Fabo2022, author = {Fabo, Sabine}, title = {Das Parasit{\"a}re in der Pandemie}, series = {Parasite Art}, journal = {Parasite Art}, number = {Issue 2}, editor = {Wirth, Jacob}, publisher = {Parasite Art}, pages = {8 -- 11}, year = {2022}, language = {de} } @article{RiglingBiglerEilmannetal.2012, author = {Rigling, Andreas and Bigler, Christof and Eilmann, Britta and Feldmeyer-Christe, Elisabeth and Gimmi, Urs and Ginzler, Christian and Graf, Ulrich and Mayer, Phillip and Vacchiano, Giorgio and Weber, Pascal and Wohlgemuth, Thomas and zweifel, Roman and Dobbertin, Matthias}, title = {Driving factors of a vegetation shift from Scots pine to pubescent oak in dry Alpine forests}, series = {Global Change Biology}, volume = {19}, journal = {Global Change Biology}, number = {1}, publisher = {Wiley-Blackwell}, address = {Oxford}, issn = {1354-1013 (Print)}, doi = {10.1111/gcb.12038}, pages = {229 -- 240}, year = {2012}, abstract = {An increasing number of studies have reported on forest declines and vegetation shifts triggered by drought. In the Swiss Rhone valley (Valais), one of the driest inner-Alpine regions, the species composition in low elevation forests is changing: The sub-boreal Scots pine (Pinus sylvestris L.) dominating the dry forests is showing high mortality rates. Concurrently the sub-Mediterranean pubescent oak (Quercus pubescens Willd.) has locally increased in abundance. However, it remains unclear whether this local change in species composition is part of a larger-scale vegetation shift. To study variability in mortality and regeneration in these dry forests we analysed data from the Swiss national forest inventory (NFI) on a regular grid between 1983 and 2003, and combined it with annual mortality data from a monitoring site. Pine mortality was found to be highest at low elevation (below 1000 m a.s.l.). Annual variation in pine mortality was correlated with a drought index computed for the summer months prior to observed tree death. A generalized linear mixed-effects model indicated for the NFI data increased pine mortality on dryer sites with high stand competition, particularly for small-diameter trees. Pine regeneration was low in comparison to its occurrence in the overstorey, whereas oak regeneration was comparably abundant. Although both species regenerated well at dry sites, pine regeneration was favoured at cooler sites at higher altitude and oak regeneration was more frequent at warmer sites, indicating a higher adaptation potential of oaks under future warming. Our results thus suggest that an extended shift in species composition is actually occurring in the pine forests in the Valais. The main driving factors are found to be climatic variability, particularly drought, and variability in stand structure and topography. Thus, pine forests at low elevations are developing into oak forests with unknown consequences for these ecosystems and their goods and services.}, language = {en} } @article{JildehOberlaenderKirchneretal.2018, author = {Jildeh, Zaid B. and Oberl{\"a}nder, Jan and Kirchner, Patrick and Keusgen, Michael and Wagner, Patrick H. and Sch{\"o}ning, Michael Josef}, title = {Experimental and Numerical Analyzes of a Sensor Based on Interdigitated Electrodes for Studying Microbiological Alterations}, series = {physica status solidi (a): applications and materials science}, volume = {215}, journal = {physica status solidi (a): applications and materials science}, number = {15}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1862-6319}, doi = {10.1002/pssa.201700920}, pages = {Artikel 1700920}, year = {2018}, abstract = {In this work, a cell-based biosensor to evaluate the sterilization efficacy of hydrogen peroxide vapor sterilization processes is characterized. The transducer of the biosensor is based on interdigitated gold electrodes fabricated on an inert glass substrate. Impedance spectroscopy is applied to evaluate the sensor behavior and the alteration of test microorganisms due to the sterilization process. These alterations are related to changes in relative permittivity and electrical conductivity of the bacterial spores. Sensor measurements are conducted with and without bacterial spores (Bacillus atrophaeus), as well as after an industrial sterilization protocol. Equivalent two-dimensional numerical models based on finite element method of the periodic finger structures of the interdigitated gold electrodes are designed and validated using COMSOL® Multiphysics software by the application of known dielectric properties. The validated models are used to compute the electrical properties at different sensor states (blank, loaded with spores, and after sterilization). As a final result, we will derive and tabulate the frequency-dependent electrical parameters of the spore layer using a novel model that combines experimental data with numerical optimization techniques.}, language = {en} } @article{EilmanndeVriesdenOudenetal.2013, author = {Eilmann, Britta and de Vries, Sven M. G. and den Ouden, Jan and Mohren, Godefridus M. J. and Sauren, Pascal and Sass-Klaassen, Ute G. W.}, title = {Origin matters! Difference in drought tolerance and productivity of coastal Douglas-fir (Pseudotsuga menziesii (Mirb.)) provenances}, series = {Forest Ecology and Management}, volume = {2013}, journal = {Forest Ecology and Management}, number = {302}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1872-7042 (Online)}, doi = {doi:10.1016/j.foreco.2013.03.031}, pages = {133 -- 143}, year = {2013}, language = {en} } @article{FrohbergAnik1984, author = {Frohberg, Martin G. and Anik, Sabri}, title = {{\"U}ber die Voraussetzungen der Wasserstoffl{\"o}slichkeit in bin{\"a}ren Eisenschmelzen}, series = {Archiv f{\"u}r das Eisenh{\"u}ttenwesen : Fachberichte}, volume = {55}, journal = {Archiv f{\"u}r das Eisenh{\"u}ttenwesen : Fachberichte}, number = {2}, issn = {0003-8962}, pages = {45 -- 48}, year = {1984}, language = {de} } @article{DallasSalphatiGomezZepedaetal.2016, author = {Dallas, Shannon and Salphati, Laurent and Gomez-Zepeda, David and Wanek, Thomas and Chen, Liangfu and Chu, Xiaoyan and Kunta, Jeevan and Mezler, Mario and Menet, Marie-Claude and Chasseigneaux, Stephanie and Decl{\`e}ves, Xavier and Langer, Oliver and Pierre, Esaie and DiLoreto, Karen and Hoft, Carolin and Laplanche, Loic and Pang, Jodie and Pereira, Tony and Andonian, Clara and Simic, Damir and Rode, Anja and Yabut, Jocelyn and Zhang, Xiaolin and Scheer, Nico}, title = {Generation and Characterization of a Breast Cancer Resistance Protein Humanized Mouse Model}, series = {Molecular Pharmacology}, volume = {89}, journal = {Molecular Pharmacology}, number = {5}, publisher = {ASPET}, address = {Bethesda, Md.}, issn = {1521-0111}, doi = {10.1124/mol.115.102079}, pages = {492 -- 504}, year = {2016}, abstract = {Breast cancer resistance protein (BCRP) is expressed in various tissues, such as the gut, liver, kidney and blood brain barrier (BBB), where it mediates the unidirectional transport of substrates to the apical/luminal side of polarized cells. Thereby BCRP acts as an efflux pump, mediating the elimination or restricting the entry of endogenous compounds or xenobiotics into tissues and it plays important roles in drug disposition, efficacy and safety. Bcrp knockout mice (Bcrp-/-) have been used widely to study the role of this transporter in limiting intestinal absorption and brain penetration of substrate compounds. Here we describe the first generation and characterization of a mouse line humanized for BCRP (hBCRP), in which the mouse coding sequence from the start to stop codon was replaced with the corresponding human genomic region, such that the human transporter is expressed under control of the murine Bcrp promoter. We demonstrate robust human and loss of mouse BCRP/Bcrp mRNA and protein expression in the hBCRP mice and the absence of major compensatory changes in the expression of other genes involved in drug metabolism and disposition. Pharmacokinetic and brain distribution studies with several BCRP probe substrates confirmed the functional activity of the human transporter in these mice. Furthermore, we provide practical examples for the use of hBCRP mice to study drug-drug interactions (DDIs). The hBCRP mouse is a promising model to study the in vivo role of human BCRP in limiting absorption and BBB penetration of substrate compounds and to investigate clinically relevant DDIs involving BCRP.}, language = {en} } @article{AnikFrohbergKapoor1983, author = {Anik, Sabri and Frohberg, Martin G. and Kapoor, Madan Lal}, title = {Experiments and theoretical considerations on the solution of oxygen in binary metal alloys}, series = {Berichte der Bunsengesellschaft f{\"u}r physikalische Chemie}, volume = {87}, journal = {Berichte der Bunsengesellschaft f{\"u}r physikalische Chemie}, number = {12}, issn = {0005-9021}, pages = {1201 -- 1204}, year = {1983}, language = {en} } @article{Fabo2009, author = {Fabo, Sabine}, title = {Chicks off speed}, series = {hello! (Boxhorn ; 19)}, volume = {2009}, journal = {hello! (Boxhorn ; 19)}, publisher = {FH Aachen, Fachbereich Gestaltung}, address = {Aachen}, issn = {1864-2535}, pages = {19 -- 21}, year = {2009}, subject = {H{\"u}hnerzucht}, language = {de} } @article{BragardBragard2012, author = {Bragard, G. and Bragard, Michael}, title = {Ein kosteng{\"u}nstiges, universelles Modellbauinterface}, series = {Der mathematische und naturwissenschaftliche Unterricht : MNU ; Organ des Deutschen Vereins zur F{\"o}rderung des Mathematischen und Naturwissenschaftlichen Unterrichts e.V.}, volume = {65}, journal = {Der mathematische und naturwissenschaftliche Unterricht : MNU ; Organ des Deutschen Vereins zur F{\"o}rderung des Mathematischen und Naturwissenschaftlichen Unterrichts e.V.}, number = {5}, publisher = {Seeberger}, address = {Neuss}, issn = {0025-5866}, pages = {290 -- 293}, year = {2012}, abstract = {Wir stellen einen USB-Baustein vor, der eine kosteng{\"u}nstige und universelle M{\"o}glichkeit schafft , im Unterricht den Themenkreis Messen-Steuern-Regeln zu behandeln. Die Funktionalit{\"a}t orientiert sich am CVK-Interface der Firma Fischertechnik. Im Gegensatz zu kommerziellen L{\"o}sungen erlaubt unser Aufbau auch den preiswerten Einsatz in Gruppen- oder Einzelarbeit. Abschließend berichten wir {\"u}ber ein Beispiel aus dem Unterrichtseinsatz.}, language = {de} }