@inproceedings{RieperGebhardtStucker2016, author = {Rieper, Harald and Gebhardt, Andreas and Stucker, Brent}, title = {Process parameters for Selective Laser Melting of AgCu7}, series = {DDMC, Fraunhofer Direct Digital Manufacturing Conference, 3}, booktitle = {DDMC, Fraunhofer Direct Digital Manufacturing Conference, 3}, publisher = {Fraunhofer-Verlag}, address = {Stuttgart}, isbn = {978-3-8396-1001-5}, pages = {171 -- 176}, year = {2016}, language = {en} } @article{DallasSalphatiGomezZepedaetal.2016, author = {Dallas, Shannon and Salphati, Laurent and Gomez-Zepeda, David and Wanek, Thomas and Chen, Liangfu and Chu, Xiaoyan and Kunta, Jeevan and Mezler, Mario and Menet, Marie-Claude and Chasseigneaux, Stephanie and Decl{\`e}ves, Xavier and Langer, Oliver and Pierre, Esaie and DiLoreto, Karen and Hoft, Carolin and Laplanche, Loic and Pang, Jodie and Pereira, Tony and Andonian, Clara and Simic, Damir and Rode, Anja and Yabut, Jocelyn and Zhang, Xiaolin and Scheer, Nico}, title = {Generation and Characterization of a Breast Cancer Resistance Protein Humanized Mouse Model}, series = {Molecular Pharmacology}, volume = {89}, journal = {Molecular Pharmacology}, number = {5}, publisher = {ASPET}, address = {Bethesda, Md.}, issn = {1521-0111}, doi = {10.1124/mol.115.102079}, pages = {492 -- 504}, year = {2016}, abstract = {Breast cancer resistance protein (BCRP) is expressed in various tissues, such as the gut, liver, kidney and blood brain barrier (BBB), where it mediates the unidirectional transport of substrates to the apical/luminal side of polarized cells. Thereby BCRP acts as an efflux pump, mediating the elimination or restricting the entry of endogenous compounds or xenobiotics into tissues and it plays important roles in drug disposition, efficacy and safety. Bcrp knockout mice (Bcrp-/-) have been used widely to study the role of this transporter in limiting intestinal absorption and brain penetration of substrate compounds. Here we describe the first generation and characterization of a mouse line humanized for BCRP (hBCRP), in which the mouse coding sequence from the start to stop codon was replaced with the corresponding human genomic region, such that the human transporter is expressed under control of the murine Bcrp promoter. We demonstrate robust human and loss of mouse BCRP/Bcrp mRNA and protein expression in the hBCRP mice and the absence of major compensatory changes in the expression of other genes involved in drug metabolism and disposition. Pharmacokinetic and brain distribution studies with several BCRP probe substrates confirmed the functional activity of the human transporter in these mice. Furthermore, we provide practical examples for the use of hBCRP mice to study drug-drug interactions (DDIs). The hBCRP mouse is a promising model to study the in vivo role of human BCRP in limiting absorption and BBB penetration of substrate compounds and to investigate clinically relevant DDIs involving BCRP.}, language = {en} } @techreport{BhattaraiFrotscherDurongetal.2016, author = {Bhattarai, Aroj and Frotscher, Ralf and Durong, Minh Tu{\´a}n and Staat, Manfred}, title = {Schlussbericht zu BINGO. Optimierung des Systems Netzimplantat-Beckenboden zur therapeutischen Gewebeverst{\"a}rkung nach der Integraltheorie.}, address = {Aachen}, pages = {34}, year = {2016}, language = {de} } @article{ScheerWilson2016, author = {Scheer, Nico and Wilson, Ian D.}, title = {A comparison between genetically humanized and chimeric liver humanized mouse models for studies in drug metabolism and toxicity}, series = {Drug Discovery Today}, volume = {21}, journal = {Drug Discovery Today}, number = {2}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1359-6446}, doi = {10.1016/j.drudis.2015.09.002}, pages = {250 -- 263}, year = {2016}, abstract = {Mice that have been genetically humanized for proteins involved in drug metabolism and toxicity and mice engrafted with human hepatocytes are emerging and promising in vivo models for an improved prediction of the pharmacokinetic, drug-drug interaction and safety characteristics of compounds in humans. The specific advantages and disadvantages of these models should be carefully considered when using them for studies in drug discovery and development. Here, an overview on the corresponding genetically humanized and chimeric liver humanized mouse models described to date is provided and illustrated with examples of their utility in drug metabolism and toxicity studies. We compare the strength and weaknesses of the two different approaches, give guidance for the selection of the appropriate model for various applications and discuss future trends and perspectives.}, language = {en} } @incollection{ScheerChuSalphatietal.2016, author = {Scheer, Nico and Chu, Xiaoyan and Salphati, Laurent and Zamek-Gliszczynski, Maciej J.}, title = {Knockout and humanized animal models to study membrane transporters in drug development}, series = {Drug Transporters: Volume 1: Role and Importance in ADME and Drug Development}, booktitle = {Drug Transporters: Volume 1: Role and Importance in ADME and Drug Development}, editor = {Nicholls, Glynis}, publisher = {Royal Society of Chemistry}, address = {Cambridge}, isbn = {978-1-78262-379-3}, doi = {10.1039/9781782623793-00298}, pages = {298 -- 332}, year = {2016}, language = {en} } @article{TuraliyevaYeshibaevSaparbekovaetal.2016, author = {Turaliyeva, M. and Yeshibaev, A. and Saparbekova, A. and Akynova, L. and Abildayeva, R. and Sadenova, M. and Sartayeva, K. and Schieffer, Andre and Digel, Ilya}, title = {Species composition and injuriousness of stranger xylophilous fauna affecting indigenous urban dendroflora of Central Asia}, series = {Asian journal of microbiology, biotechnology \& environmental sciences : AJMBES}, volume = {18}, journal = {Asian journal of microbiology, biotechnology \& environmental sciences : AJMBES}, number = {2}, publisher = {EM International}, issn = {0972-3005}, pages = {359 -- 366}, year = {2016}, abstract = {At the present time, one of the most serious environmental problems of Central Asia and South Kazakhstan is the ongoing large-scale deterioration of principal urban tree populations. Several major centers of massive spread of invasive plant pests have been found in urban dendroflora of this region. The degree of damage of seven most wide-spread aboriginal tree species was found to range from 21.4±1.1 to 85.4±1.8\%. In particular, the integrity of the native communities of sycamore (Platanus spp.), willow (Salix spp.), poplar (Populus spp.) and elm (Ulmus spp.) is highly endangered. Our taxonomic analysis of the most dangerous tree pests of the region has revealed them as neobiontic xylophilous insects such as Cossus cossus L. (Order: Lepidoptera L.) Monochamus urussovi Fisch., Monochamus sutor L., Acanthocinus aedelis L. and {\~N}etonia aureate L. (Order: Coleoptera L.). We relate the origin of this threatening trend with the import of industrial wood in the mid 90’s of the last century that was associated with high degree of the constructional work in the region. Because of the absence of efficient natural predators of the pest species, the application of microbiological methods of the pest control and limitation is suggested.}, language = {en} } @article{AimenovaDigelEshibaev2016, author = {Aimenova, Zh. E. and Digel, Ilya and Eshibaev, А. А.}, title = {Dynamics of accumulation of lagochirzin in Lagochilus setulosus phytomass during the growing season and also features of its cultivation in the conditions of a typical sierozem}, series = {KazNU Bulletin. Biology series}, volume = {69}, journal = {KazNU Bulletin. Biology series}, number = {4}, publisher = {Al-Farabi Kazakh National University}, address = {Almaty}, issn = {1563-0218}, pages = {4 -- 11}, year = {2016}, abstract = {L.setulosus is offered for creation of biopreparation «Setulin», possesing he- mostatic action, the basic reactant of biopreparation is diterpen - lagochirzin. Results under the maintenance and dynamics of diterpen lagochirzin accumula- tion in various parts of L.setulosus are presented: in roots, stalks, leaves, flowers and calyx lobes during the growing season, and also results on conditions of cultivation L.setulosus in the conditions of a typical sierozem are resulted. From the obtained data is visible, that the given species of a plant is endemic. It is established, that dynamics of accumulation of lagochirzin in phytomass accrues from the beginning to the middle of the growing season. The chemical analysis of L.setulosus on a localization of lagochirzin in various organs of a plant, has shown, that the greatest quantity of lagochirzin collects in calyx lobes of the plants. Also it is established, that L.setulosus can be cultivated in the conditions of the typical sierozem, a mineral food is necessary for the given species of plants of Lagochilus genus, except nitric fertilizers. Comparative studying of wild-growing and cultural forms of L.setulosus has shown, that in the cultivated phytomass of plants the maintenance of lagochirzin on 17-20 \% higher than in the wild-growing species.}, language = {en} } @incollection{ButenwegKubalskiMarinkovicetal.2016, author = {Butenweg, Christoph and Kubalski, Thomas and Marinkovic, Marko and Pfetzing, Thomas and Ismail, Mohammed and Fehling, Ekkehard}, title = {Ausfachungen aus Ziegelmauerwerk}, series = {Mauerwerk-Kalender 2016: Baustoffe, Sanierung, Eurocode-Praxis}, booktitle = {Mauerwerk-Kalender 2016: Baustoffe, Sanierung, Eurocode-Praxis}, publisher = {Ernst \& Sohn}, address = {Berlin}, isbn = {978-3-433-03131-5}, year = {2016}, language = {de} } @article{RosinButenwegKlinkel2016, author = {Rosin, Julia and Butenweg, Christoph and Klinkel, Sven}, title = {Stabilit{\"a}tsnachweis f{\"u}r seismisch beanspruchte Tankbauwerke nach dem LBA/MNA-Konzept}, series = {Bauingenieur}, volume = {91}, journal = {Bauingenieur}, number = {12}, publisher = {VDI Fachmedien}, address = {D{\"u}sseldorf}, issn = {0005-6650}, doi = {10.37544/0005-6650-2016-12-74}, pages = {518 -- 526}, year = {2016}, abstract = {Eine seismische Anregung verursacht in einem Fl{\"u}ssigkeitstank einen kombinierten Spannungszustand, was zu einem Stabilit{\"a}tsversagen der h{\"a}ufig sehr d{\"u}nnwandigen Konstruktionen f{\"u}hren kann. F{\"u}r die Durchf{\"u}hrung von Stabilit{\"a}tsnachweisen stehen verschiedene Verfahren zur Verf{\"u}gung. {\"U}blicherweise werden aus Gr{\"u}nden der Einfachheit spannungsbasierte Verfahren angewendet. Diese sind f{\"u}r Einheitslastf{\"a}lle experimentell abgesichert, wobei eine {\"U}bertragung auf kombinierte Spannungszust{\"a}nde wie im Erdbebenfall nur begrenzt m{\"o}glich ist. Alternativ kann ein globales, numerisches Konzept, das LBA/MNA-Verfahren, angewendet werden. Das Verfahren kombiniert eine materiell nichtlineare Berechnung (MNA) mit einer linearen Beulanalyse (LBA) und erfasst die Interaktion verschiedener gleichzeitig auftretender Beanspruchungen implizit im Nachweis. Dieser Beitrag demonstriert die Anwendung der Verfahren am Beispiel verschiedener Tankgeometrien mit H{\"o}he/Radius-Verh{\"a}ltnissen zwischen 1 ≤ H/R ≤ 2 und Radius/Tankwand-Verh{\"a}ltnissen zwischen 500 ≤ R/t ≤ 1000 und diskutiert zus{\"a}tzlich die Defizite der spannungsbasierten Nachweisverfahren.}, language = {de} } @article{ButenwegMarinkovicKubalskietal.2016, author = {Butenweg, Christoph and Marinkovic, Marko and Kubalski, Thomas and Klinkel, Sven}, title = {Masonry infilled reinforced concrete frames under horizontal loading}, series = {Mauerwerk}, volume = {20}, journal = {Mauerwerk}, number = {4}, publisher = {Ernst \& Sohn}, address = {Berlin}, issn = {1437-1022}, doi = {10.1002/dama.201600703}, pages = {305 -- 312}, year = {2016}, abstract = {The behaviour of infilled reinforced concrete frames under horizontal load has been widely investigated, both experimentally and numerically. Since experimental tests represent large investments, numerical simulations offer an efficient approach for a more comprehensive analysis. When RC frames with masonry infill walls are subjected to horizontal loading, their behaviour is highly non-linear after a certain limit, which makes their analysis quite difficult. The non-linear behaviour results from the complex inelastic material properties of the concrete, infill wall and conditions at the wall-frame interface. In order to investigate this non-linear behaviour in detail, a finite element model using a micro modelling approach is developed, which is able to predict the complex non-linear behaviour resulting from the different materials and their interaction. Concrete and bricks are represented by a non-linear material model, while each reinforcement bar is represented as an individual part installed in the concrete part and behaving elasto-plastically. Each brick is modelled individually and connected taking into account the non-linearity of a brick mortar interface. The same approach is followed using two finite element software packages and the results are compared with the experimental results. The numerical models show a good agreement with the experiments in predicting the overall behaviour, but also very good matching for strength capacity and drift. The results emphasize the quality and the valuable contribution of the numerical models for use in parametric studies, which are needed for the derivation of design recommendations for infilled frame structures.}, language = {en} } @inproceedings{KubalskiMarinkovićButenweg2016, author = {Kubalski, T. and Marinković, Marko and Butenweg, Christoph}, title = {Numerical investigation of masonry infilled R.C. frames}, series = {Brick and Block Masonry. Proceedings of the 16th International Brick and Block Masonry Conference, Padova, Italy, 26-30 June 2016}, booktitle = {Brick and Block Masonry. Proceedings of the 16th International Brick and Block Masonry Conference, Padova, Italy, 26-30 June 2016}, editor = {Modena, Claudio}, publisher = {CRC Press}, address = {Leiden}, isbn = {9781315374963}, pages = {1219 -- 1226}, year = {2016}, language = {en} } @inproceedings{KolditzAlbinAlbrachtetal.2016, author = {Kolditz, Melanie and Albin, Thivaharan and Albracht, Kirsten and Br{\"u}ggemann, Gert-Peter and Abel, Dirk}, title = {Isokinematic leg extension training with an industrial robot}, series = {6th IEEE RAS/EMBS International Conference on Biomedical Robotics and Biomechatronics (BioRob) June 26-29, 2016. UTown, Singapore}, booktitle = {6th IEEE RAS/EMBS International Conference on Biomedical Robotics and Biomechatronics (BioRob) June 26-29, 2016. UTown, Singapore}, doi = {10.1109/BIOROB.2016.7523750}, pages = {950 -- 955}, year = {2016}, language = {de} } @article{BungValero2016, author = {Bung, Daniel Bernhard and Valero, Daniel}, title = {Optical flow estimation in aerated flows}, series = {Journal of Hydraulic Research}, volume = {54}, journal = {Journal of Hydraulic Research}, number = {5}, publisher = {Taylor \& Francis}, address = {London}, doi = {10.1080/00221686.2016.1173600}, pages = {575 -- 580}, year = {2016}, abstract = {Optical flow estimation is known from Computer Vision where it is used to determine obstacle movements through a sequence of images following an assumption of brightness conservation. This paper presents the first study on application of the optical flow method to aerated stepped spillway flows. For this purpose, the flow is captured with a high-speed camera and illuminated with a synchronized LED light source. The flow velocities, obtained using a basic Horn-Schunck method for estimation of the optical flow coupled with an image pyramid multi-resolution approach for image filtering, compare well with data from intrusive conductivity probe measurements. Application of the Horn-Schunck method yields densely populated flow field data sets with velocity information for every pixel. It is found that the image pyramid approach has the most significant effect on the accuracy compared to other image processing techniques. However, the final results show some dependency on the pixel intensity distribution, with better accuracy found for grey values between 100 and 150.}, language = {en} } @inproceedings{KerpenBungValeroetal.2016, author = {Kerpen, Nils B. and Bung, Daniel Bernhard and Valero, Daniel and Schlurmann, Torsten}, title = {Energy dissipation within the wave run-up at stepped revetments}, series = {8th Chinese-German Joint Symposium on Hydraulic and Ocean Engineering, Qingdao, China}, booktitle = {8th Chinese-German Joint Symposium on Hydraulic and Ocean Engineering, Qingdao, China}, pages = {6 Seiten}, year = {2016}, language = {en} } @inproceedings{BungValero2016, author = {Bung, Daniel Bernhard and Valero, Daniel}, title = {Image processing techniques for velocity estimation in highly aerated flows: bubble image velocimetry vs. optical flow}, series = {Sustainable Hydraulics in the Era of Global Change : Proceedings of the 4th IAHR Europe Congress (Liege, Belgium, 27-29 July 2016)}, booktitle = {Sustainable Hydraulics in the Era of Global Change : Proceedings of the 4th IAHR Europe Congress (Liege, Belgium, 27-29 July 2016)}, editor = {Dewals, Benjamin}, publisher = {CRC Press}, isbn = {978-1-138-02977-4}, doi = {10.1201/b21902-31}, pages = {151 -- 157}, year = {2016}, language = {en} } @book{Schmidt2016, author = {Schmidt, Bernd}, title = {Grundlagen der Elektrotechnik und Elektronik f{\"u}r Ingenieure der Schienenfahrzeugtechnik und anderer Fachrichtungen}, edition = {1. Aufl.}, publisher = {B. Schmidt, Fachverlag f{\"u}r Elektro- und Informationstechnik}, address = {Bielefeld}, isbn = {978-3-944131-02-3}, pages = {XXIII, 255 Seiten : Illustrationen}, year = {2016}, language = {de} } @article{PfaffSchmidt2016, author = {Pfaff, Raphael and Schmidt, Bernd}, title = {Daten in der Cloud - und dann?}, series = {Deine Bahn}, journal = {Deine Bahn}, number = {6}, publisher = {Bahn-Fachverlag}, address = {Berlin}, issn = {0948-7263}, pages = {50 -- 55}, year = {2016}, abstract = {Schienenverkehrssysteme stehen in zunehmendem Wettbewerb, sowohl untereinander als auch mit anderen Verkehrstr{\"a}gern. Als wichtiger Aspekt zur Steigerung der Kosteneffizienz wird die Digitalisierung des Betriebs und der Fahrzeuge betrachtet. {\"U}ber eine Prognose der Ausfallwahrscheinlichkeit bzw. Restlebensdauer von Subsystemen k{\"o}nnen mittels Digitalisierung die Instandhaltungskosten gesenkt werden. Die geringen Fehlerraten im System Bahn machen die Nutzung besonderer Simulationstechniken notwendig. In diesem Beitrag wird gezeigt, wie sich die Subsystemverf{\"u}gbarkeit aus den beobachteten Fehlerraten der Teilfunktionen vorhersagen l{\"a}sst.}, language = {de} } @incollection{SchulteZurhausen2016, author = {Schulte-Zurhausen, Manfred}, title = {Systemisches Management von Organisationsprojekten}, series = {Projekte systemisch managen! Wie Sie soziale und rationale Prozesse in Projekten achtsam steuern}, booktitle = {Projekte systemisch managen! Wie Sie soziale und rationale Prozesse in Projekten achtsam steuern}, editor = {Stelzer-Rothe, Thomas}, publisher = {BWV Berliner Wissenschafts-Verlag}, address = {Berlin}, isbn = {978-3-8305-3647-5}, pages = {9 -- 34}, year = {2016}, language = {de} } @article{RoeschKratzHeringetal.2016, author = {R{\"o}sch, C. and Kratz, F. and Hering, T. and Trautmann, S. and Umanskaya, N. and Tippk{\"o}tter, Nils and M{\"u}ller-Renno, C.M. and Ulber, Roland and Hannig, M. and Ziegler, C.}, title = {Albumin-lysozyme interactions: cooperative adsorption on titanium and enzymatic activity}, series = {Colloids and Surfaces B: Biointerfaces}, volume = {149}, journal = {Colloids and Surfaces B: Biointerfaces}, number = {1}, publisher = {Elsevier}, address = {Amsterdam}, doi = {10.1016/j.colsurfb.2016.09.048}, pages = {115 -- 121}, year = {2016}, abstract = {The interplay of albumin (BSA) and lysozyme (LYZ) adsorbed simultaneously on titanium was analyzed by gel electrophoresis and BCA assay. It was found that BSA and lysozyme adsorb cooperatively. Additionally, the isoelectric point of the respective protein influences the adsorption. Also, the enzymatic activity of lysozyme and amylase (AMY) in mixtures with BSA was considered with respect to a possible influence of protein-protein interaction on enzyme activity. Indeed, an increase of lysozyme activity in the presence of BSA could be observed. In contrast, BSA does not influence the activity of amylase.}, language = {en} } @article{RothTippkoetter2016, author = {Roth, Jasmine and Tippk{\"o}tter, Nils}, title = {Evaluation of lignocellulosic material for butanol production using enzymatic hydrolysate medium}, series = {Cellulose Chemistry and Technology}, volume = {50}, journal = {Cellulose Chemistry and Technology}, number = {3-4}, publisher = {Editura Academiei Romane}, address = {Bukarest}, pages = {405 -- 410}, year = {2016}, abstract = {Butanol is a promising gasoline additive and platform chemical that can be readily produced via acetone-butanolethanol (ABE) fermentation from pretreated lignocellulosic materials. This article examines lignocellulosic material from beech wood for ABE fermentation, using Clostridium acetobutylicum. First, the utilization of both C₅₋ (xylose) and C₆₋ (glucose) sugars as sole carbon source was investigated in static cultivation, using serum bottles and synthetic medium. The utilization of pentose sugar resulted in a solvent yield of 0.231 g·g_sugar⁻¹, compared to 0.262 g·g_sugar⁻¹ using hexose. Then, the Organosolv pretreated crude cellulose fibers (CF) were enzymatically decomposed, and the resulting hydrolysate medium was analyzed for inhibiting compounds (furans, organic acids, phenolics) and treated with ionexchangers for detoxification. Batch fermentation in a bioreactor using CF hydrolysate medium resulted in a total solvent yield of 0.20 gABE·g_sugar⁻¹.}, language = {en} }