@incollection{MacdonaldMcGrathAppourchauxetal.2014, author = {Macdonald, Malcolm and McGrath, C. and Appourchaux, T. and Dachwald, Bernd and Finsterle, W. and Gizon, L. and Liewer, P. C. and McInnes, Colin R. and Mengali, G. and Seboldt, Wolfgang and Sekii, T. and Solanki, S. K. and Velli, M. and Wimmer-Schweingruber, R. F. and Spietz, Peter and Reinhard, Ruedeger}, title = {Gossamer roadmap technology reference study for a solar polar mission}, series = {Advances in solar sailing}, booktitle = {Advances in solar sailing}, editor = {Macdonald, Malcolm}, publisher = {Springer}, address = {Berlin, Heidelberg}, isbn = {978-3-642-34906-5}, doi = {10.1007/978-3-642-34907-2_17}, pages = {243 -- 257}, year = {2014}, abstract = {A technology reference study for a solar polar mission is presented. The study uses novel analytical methods to quantify the mission design space including the required sail performance to achieve a given solar polar observation angle within a given timeframe and thus to derive mass allocations for the remaining spacecraft sub-systems, that is excluding the solar sail sub-system. A parametric, bottom-up, system mass budget analysis is then used to establish the required sail technology to deliver a range of science payloads, and to establish where such payloads can be delivered to within a given timeframe. It is found that a solar polar mission requires a solar sail of side-length 100-125 m to deliver a 'sufficient value' minimum science payload, and that a 2.5 μm sail film substrate is typically required, however the design is much less sensitive to the boom specific mass.}, language = {en} } @incollection{Golland2020, author = {Golland, Alexander}, title = {Struggling with users' consent: Economic approach to solve the issue of coupling}, series = {Turning Point in Data Protection Law}, booktitle = {Turning Point in Data Protection Law}, publisher = {Nomos}, address = {Baden-Baden}, isbn = {978-3-8487-6909-4}, doi = {10.5771/9783748921561-121}, pages = {121 -- 126}, year = {2020}, language = {en} } @incollection{HinkeVervierBrauneretal.2022, author = {Hinke, Christian and Vervier, Luisa and Brauner, Philipp and Schneider, Sebastian and Steuer-Dankert, Linda and Ziefle, Martina and Leicht-Scholten, Carmen}, title = {Capability configuration in next generation manufacturing}, series = {Forecasting next generation manufacturing : digital shadows, human-machine collaboration, and data-driven business models}, booktitle = {Forecasting next generation manufacturing : digital shadows, human-machine collaboration, and data-driven business models}, publisher = {Springer}, address = {Cham}, isbn = {978-3-031-07733-3}, doi = {10.1007/978-3-031-07734-0_6}, pages = {95 -- 106}, year = {2022}, abstract = {Industrial production systems are facing radical change in multiple dimensions. This change is caused by technological developments and the digital transformation of production, as well as the call for political and social change to facilitate a transformation toward sustainability. These changes affect both the capabilities of production systems and companies and the design of higher education and educational programs. Given the high uncertainty in the likelihood of occurrence and the technical, economic, and societal impacts of these concepts, we conducted a technology foresight study, in the form of a real-time Delphi analysis, to derive reliable future scenarios featuring the next generation of manufacturing systems. This chapter presents the capabilities dimension and describes each projection in detail, offering current case study examples and discussing related research, as well as implications for policy makers and firms. Specifically, we discuss the benefits of capturing expert knowledge and making it accessible to newcomers, especially in highly specialized industries. The experts argue that in order to cope with the challenges and circumstances of today's world, students must already during their education at university learn how to work with AI and other technologies. This means that study programs must change and that universities must adapt their structural aspects to meet the needs of the students.}, language = {en} } @incollection{MeskourisButenwegHinzenetal.2019, author = {Meskouris, Konstantin and Butenweg, Christoph and Hinzen, Klaus-G. and H{\"o}ffer, R{\"u}diger}, title = {Stochasticity of Wind Processes and Spectral Analysis of Structural Gust Response}, series = {Structural Dynamics with Applications in Earthquake and Wind Engineering}, booktitle = {Structural Dynamics with Applications in Earthquake and Wind Engineering}, publisher = {Springer}, address = {Berlin}, isbn = {978-3-662-57550-5 (Online)}, doi = {10.1007/978-3-662-57550-5_3}, pages = {153 -- 196}, year = {2019}, abstract = {Wind loads have great impact on many engineering structures. Wind storms often cause irreparable damage to the buildings which are exposed to it. Along with the earthquakes, wind represents one of the most common environmental load on structures and is relevant for limit state design. Modern wind codes indicate calculation procedures allowing engineers to deal with structural systems, which are susceptible to conduct wind-excited oscillations. In the codes approximate formulas for wind buffeting are specified which relate the dynamic problem to rather abstract parameter functions. The complete theory behind is not visible in order to simplify the applicability of the procedures. This chapter derives the underlying basic relations of the spectral method for wind buffeting and explains the main important applications of it in order to elucidate part of the theoretical background of computations after the new codes. The stochasticity of the wind processes is addressed, and the analysis of analytical as well as measurement based power spectra is outlined. Short MATLAB codes are added to the Appendix 3 which carry out the computation of a single sided auto-spectrum from a statistically stationary, discrete stochastic process. Two examples are presented.}, language = {en} } @incollection{DigelAkimbekovKistaubayevaetal.2018, author = {Digel, Ilya and Akimbekov, Nuraly S. and Kistaubayeva, Aida and Zhubanova, Azhar A.}, title = {Microbial Sampling from Dry Surfaces: Current Challenges and Solutions}, series = {Biological, Physical and Technical Basics of Cell Engineering}, booktitle = {Biological, Physical and Technical Basics of Cell Engineering}, editor = {Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l and Zhubanova, Azhar A. and Digel, Ilya}, publisher = {Springer}, address = {Singapore}, isbn = {978-981-10-7904-7}, doi = {10.1007/978-981-10-7904-7_19}, pages = {421 -- 456}, year = {2018}, abstract = {Sampling of dry surfaces for microorganisms is a main component of microbiological safety and is of critical importance in many fields including epidemiology, astrobiology as well as numerous branches of medical and food manufacturing. Aspects of biofilm formation, analysis and removal in aqueous solutions have been thoroughly discussed in literature. In contrast, microbial communities on air-exposed (dry) surfaces have received significantly less attention. Diverse surface sampling methods have been developed in order to address various surfaces and microbial groups, but they notoriously show poor repeatability, low recovery rates and suffer from lack of mutual consistency. Quantitative sampling for viable microorganisms represents a particular challenge, especially on porous and irregular surfaces. Therefore, it is essential to examine in depth the factors involved in microorganisms' recovery efficiency and accuracy depending on the sampling technique used. Microbial colonization, retention and community composition on different dry surfaces are very complex and rely on numerous physicochemical and biological factors. This study is devoted to analyze and review the (a) physical phenomena and intermolecular forces relevant for microbiological surface sampling; (b) challenges and problems faced by existing sampling methods for viable microorganisms and (c) current directions of engineering and research aimed at improvement of quality and efficiency of microbiological surface sampling.}, language = {en} } @incollection{StaatHeitzer2003, author = {Staat, Manfred and Heitzer, M.}, title = {Basis reduction technique for limit and shakedown problems}, series = {Numerical Methods for Limit and Shakedown Analysis. Deterministic and Probabilistic Approach. NIC Series Vol. 15 / Ed. by Staat, M.; Heitzer, M.}, booktitle = {Numerical Methods for Limit and Shakedown Analysis. Deterministic and Probabilistic Approach. NIC Series Vol. 15 / Ed. by Staat, M.; Heitzer, M.}, publisher = {John von Neumann Institute for Computing (NIC)}, address = {J{\"u}lich}, isbn = {3-00-010001-6}, url = {http://nbn-resolving.de/urn:nbn:de:0001-2018112115}, pages = {1 -- 55}, year = {2003}, language = {en} } @incollection{StriebingMuellerSchraudneretal.2022, author = {Striebing, Clemens and M{\"u}ller, J{\"o}rg and Schraudner, Martina and Gewinner, Irina Valerie and Guerrero Morales, Patricia and Hochfeld, Katharina and Hoffman, Shekinah and Kmec, Julie A. and Nguyen, Huu Minh and Schneider, Jannick and Sheridan, Jennifer and Steuer-Dankert, Linda and Trimble O'Connor, Lindsey and Vandevelde-Rougale, Agn{\`e}s}, title = {Promoting diversity and combatting discrimination in research organizations: a practitioner's guide}, series = {Diversity and discrimination in research organizations}, booktitle = {Diversity and discrimination in research organizations}, publisher = {Emerald Publishing Limited}, address = {Bingley}, isbn = {978-1-80117-959-1 (Print)}, doi = {10.1108/978-1-80117-956-020221012}, pages = {421 -- 442}, year = {2022}, abstract = {The essay is addressed to practitioners in research management and from academic leadership. It describes which measures can contribute to creating an inclusive climate for research teams and preventing and effectively dealing with discrimination. The practical recommendations consider the policy and organizational levels, as well as the individual perspective of research managers. Following a series of basic recommendations, six lessons learned are formulated, derived from the contributions to the edited collection on "Diversity and Discrimination in Research Organizations."}, language = {en} } @incollection{SteuerDankertLeichtScholten2022, author = {Steuer-Dankert, Linda and Leicht-Scholten, Carmen}, title = {Perceiving diversity : an explorative approach in a complex research organization.}, series = {Diversity and discrimination in research organizations}, booktitle = {Diversity and discrimination in research organizations}, publisher = {Emerald Publishing Limited}, address = {Bingley}, isbn = {978-1-80117-959-1 (Print)}, doi = {10.1108/978-1-80117-956-020221010}, pages = {365 -- 392}, year = {2022}, abstract = {Diversity management is seen as a decisive factor for ensuring the development of socially responsible innovations (Beacham and Shambaugh, 2011; Sonntag, 2014; L{\´o}pez, 2015; Uebernickel et al., 2015). However, many diversity management approaches fail due to a one-sided consideration of diversity (Thomas and Ely, 2019) and a lacking linkage between the prevailing organizational culture and the perception of diversity in the respective organization. Reflecting the importance of diverse perspectives, research institutions have a special responsibility to actively deal with diversity, as they are publicly funded institutions that drive socially relevant development and educate future generations of developers, leaders and decision-makers. Nevertheless, only a few studies have so far dealt with the influence of the special framework conditions of the science system on diversity management. Focusing on the interdependency of the organizational culture and diversity management especially in a university research environment, this chapter aims in a first step to provide a theoretical perspective on the framework conditions of a complex research organization in Germany in order to understand the system-specific factors influencing diversity management. In a second step, an exploratory cluster analysis is presented, investigating the perception of diversity and possible influencing factors moderating this perception in a scientific organization. Combining both steps, the results show specific mechanisms and structures of the university research environment that have an impact on diversity management and rigidify structural barriers preventing an increase of diversity. The quantitative study also points out that the management level takes on a special role model function in the scientific system and thus has an influence on the perception of diversity. Consequently, when developing diversity management approaches in research organizations, it is necessary to consider the top-down direction of action, the special nature of organizational structures in the university research environment as well as the special role of the professorial level as role model for the scientific staff.}, language = {en} } @incollection{OsterhageBialonskiStanieketal.2008, author = {Osterhage, Hannes and Bialonski, Stephan and Staniek, Matth{\"a}us and Schindler, Kaspar and Wagner, Tobias and Elger, Christian E. and Lehnertz, Klaus}, title = {Bivariate and multivariate time series analysis techniques and their potential impact for seizure prediction}, series = {Seizure Prediction in Epilepsy: From Basic Mechanisms to Clinical Applications}, booktitle = {Seizure Prediction in Epilepsy: From Basic Mechanisms to Clinical Applications}, publisher = {Wiley-VCH}, address = {Weinheim}, isbn = {978-3-527-62519-2}, doi = {10.1002/9783527625192.ch15}, pages = {189 -- 208}, year = {2008}, language = {en} } @incollection{LeichtScholtenSteuerDankert2020, author = {Leicht-Scholten, Carmen and Steuer-Dankert, Linda}, title = {Educating engineers for socially responsible solutions through design thinking}, series = {Design thinking in higher education: interdisciplinary encounters}, booktitle = {Design thinking in higher education: interdisciplinary encounters}, publisher = {Springer}, address = {Singapore}, isbn = {978-981-15-5780-4}, doi = {10.1007/978-981-15-5780-4}, pages = {229 -- 246}, year = {2020}, abstract = {There is a broad international discussion about rethinking engineering education in order to educate engineers to cope with future challenges, and particularly the sustainable development goals. In this context, there is a consensus about the need to shift from a mostly technical paradigm to a more holistic problem-based approach, which can address the social embeddedness of technology in society. Among the strategies suggested to address this social embeddedness, design thinking has been proposed as an essential complement to engineering precisely for this purpose. This chapter describes the requirements for integrating the design thinking approach in engineering education. We exemplify the requirements and challenges by presenting our approach based on our course experiences at RWTH Aachen University. The chapter first describes the development of our approach of integrating design thinking in engineering curricula, how we combine it with the Sustainable Development Goals (SDG) as well as the role of sustainability and social responsibility in engineering. Secondly, we present the course "Expanding Engineering Limits: Culture, Diversity, and Gender" at RWTH Aachen University. We describe the necessity to theoretically embed the method in social and cultural context, giving students the opportunity to reflect on cultural, national, or individual "engineering limits," and to be able to overcome them using design thinking as a next step for collaborative project work. The paper will suggest that the successful implementation of design thinking as a method in engineering education needs to be framed and contextualized within Science and Technology Studies (STS).}, language = {en} } @incollection{EversFleischhakerPalffyetal.2010, author = {Evers, J{\"o}rg and Fleischhaker, Robert and P{\´a}lffy, A. and Keitel, C.}, title = {Light propagation : From atomic to nuclear quantum optics}, series = {Modern optics and photonics: atoms and structured media}, booktitle = {Modern optics and photonics: atoms and structured media}, publisher = {World Scientific Publishing Co.}, isbn = {978-981431327-8}, doi = {10.1142/9789814313278_0001}, pages = {3 -- 15}, year = {2010}, language = {en} } @incollection{WolfKapelyukhScheeretal.2015, author = {Wolf, C. Roland and Kapelyukh, Yury and Scheer, Nico and Henderson, Colin J.}, title = {Application of Humanised and Other Transgenic Models to Predict Human Responses to Drugs}, editor = {Wilson, Alan G. E.}, publisher = {RSC Publ.}, address = {Cambridge}, isbn = {978-1-78262-778-4}, doi = {10.1039/9781782622376-00152}, pages = {152 -- 176}, year = {2015}, abstract = {The use of transgenic animal models has transformed our knowledge of complex biochemical pathways in vivo. It has allowed disease processes to be modelled and used in the development of new disease prevention and treatment strategies. They can also be used to define cell- and tissue-specific pathways of gene regulation. A further major application is in the area of preclinical development where such models can be used to define pathways of chemical toxicity, and the pathways that regulate drug disposition. One major application of this approach is the humanisation of mice for the proteins that control drug metabolism and disposition. Such models can have numerous applications in the development of drugs and in their more sophisticated use in the clinic.}, language = {en} } @incollection{HendersonWolfScheer2009, author = {Henderson, Colin J. and Wolf, C. Roland and Scheer, Nico}, title = {The use of transgenic animals to study drug metabolism}, series = {Handbook of Drug Metabolism. 2nd Edition}, booktitle = {Handbook of Drug Metabolism. 2nd Edition}, editor = {Woolf, Thomas F.}, publisher = {Informa Healthcare}, address = {New York}, isbn = {978-1-4200-7647-9}, pages = {637 -- 658}, year = {2009}, language = {en} } @incollection{FranzenSteckenPfaffetal.2019, author = {Franzen, Julian and Stecken, Jannis and Pfaff, Raphael and Kuhlenk{\"o}tter, Bernd}, title = {Using the Digital Shadow for a Prescriptive Optimization of Maintenance and Operation : The Locomotive in the Context of the Cyber-Physical System}, series = {Advances in Production, Logistics and Traffic}, booktitle = {Advances in Production, Logistics and Traffic}, publisher = {Springer}, address = {Cham}, isbn = {978-3-030-13535-5}, doi = {10.1007/978-3-030-13535-5_19}, pages = {265 -- 276}, year = {2019}, abstract = {In competition with other modes of transport, rail freight transport is looking for solutions to become more attractive. Short-term success can be achieved through the data-driven optimization of operations and maintenance as well as the application of novel strategies such as prescriptive maintenance. After introducing the concept of prescriptive maintenance, this paper aims to prove that vehicle-focused applications of this approach indeed have the potential to increase attractiveness. However, even greater advantages can be activated if data from the horizontal network of the vehicle is available. Drawing on the state of the art in research and technology in the field of cyber-physical systems (CPS) as well as digital twins and shadows, our work serves to design a system of systems for the horizontal interconnection of a rail vehicle and to conceptualize a draft for a digital twin of a locomotive.}, language = {en} } @incollection{SamuelssonScheerWilsonetal.2017, author = {Samuelsson, K. and Scheer, Nico and Wilson, I. and Wolf, C.R. and Henderson, C.J.}, title = {Genetically Humanized Animal Models}, series = {Comprehensive Medicinal Chemistry III. 3rd Edition}, booktitle = {Comprehensive Medicinal Chemistry III. 3rd Edition}, editor = {Chackalamannil, Samuel}, publisher = {Elsevier}, address = {Saint Louis}, isbn = {978-0-12-803201-5}, doi = {10.1016/B978-0-12-409547-2.12376-5}, pages = {130 -- 149}, year = {2017}, abstract = {Genetically humanized mice for proteins involved in drug metabolism and toxicity and mice engrafted with human hepatocytes are emerging as promising in vivo models for improved prediction of the pharmacokinetic, drug-drug interaction, and safety characteristics of compounds in humans. This is an overview on the genetically humanized and chimeric liver-humanized mouse models, which are illustrated with examples of their utility in drug metabolism and toxicity studies. The models are compared to give guidance for selection of the most appropriate model by highlighting advantages and disadvantages to be carefully considered when used for studies in drug discovery and development.}, language = {en} } @incollection{ScheerChuSalphatietal.2016, author = {Scheer, Nico and Chu, Xiaoyan and Salphati, Laurent and Zamek-Gliszczynski, Maciej J.}, title = {Knockout and humanized animal models to study membrane transporters in drug development}, series = {Drug Transporters: Volume 1: Role and Importance in ADME and Drug Development}, booktitle = {Drug Transporters: Volume 1: Role and Importance in ADME and Drug Development}, editor = {Nicholls, Glynis}, publisher = {Royal Society of Chemistry}, address = {Cambridge}, isbn = {978-1-78262-379-3}, doi = {10.1039/9781782623793-00298}, pages = {298 -- 332}, year = {2016}, language = {en} } @incollection{MatchaBarczik2011, author = {Matcha, Heike and Barczik, G{\"u}nter}, title = {Mass Diversity: Individualized housing via parametric typology}, series = {Structuralism Reloaded? Rule-Based Design in Architecture and Urbanism}, booktitle = {Structuralism Reloaded? Rule-Based Design in Architecture and Urbanism}, editor = {Valena, Tomas and Avermaete, Tom and Vrachliotis, Georg}, publisher = {Edition Axel Menges}, address = {Fellbach}, isbn = {978-3-936681-47-5}, pages = {354 -- 358}, year = {2011}, language = {en} } @incollection{BozakovSander2013, author = {Bozakov, Zdravko and Sander, Volker}, title = {OpenFlow: A Perspective for Building Versatile Networks}, series = {Network-Embedded Management and Applications}, booktitle = {Network-Embedded Management and Applications}, publisher = {Springer}, address = {New York, NY}, isbn = {978-1-4419-6769-5}, doi = {10.1007/978-1-4419-6769-5_11}, pages = {217 -- 245}, year = {2013}, language = {en} } @incollection{FateriGebhardt2020, author = {Fateri, Miranda and Gebhardt, Andreas}, title = {Introduction to Additive Manufacturing}, series = {3D Printing of Optical Components}, booktitle = {3D Printing of Optical Components}, publisher = {Springer}, address = {Cham}, isbn = {978-3-030-58960-8}, doi = {10.1007/978-3-030-58960-8_1}, pages = {1 -- 22}, year = {2020}, abstract = {Additive manufacturing (AM) works by creating objects layer by layer in a manner similar to a 2D printer with the "printed" layers stacked on top of each other. The layer-wise manufacturing nature of AM enables fabrication of freeform geometries which cannot be fabricated using conventional manufacturing methods as a one part. Depending on how each layer is created and bonded to the adjacent layers, different AM methods have been developed. In this chapter, the basic terms, common materials, and different methods of AM are described, and their potential applications are discussed.}, language = {en} } @incollection{GebhardtHoetter2019, author = {Gebhardt, Andreas and Hoetter, Jan-Steffen}, title = {Rapid Tooling}, series = {CIRP Encyclopedia of Production Engineering}, booktitle = {CIRP Encyclopedia of Production Engineering}, publisher = {Springer}, address = {Berlin, Heidelberg}, isbn = {978-3-662-53120-4}, doi = {10.1007/978-3-662-53120-4}, pages = {39 -- 52}, year = {2019}, language = {en} }