@masterthesis{Herrmann2023,
  type      = {Bachelor Thesis},
  author    = {Herrmann, Luna},
  title     = {Blind Shopping},
  publisher = {FH Aachen},
  address   = {Aachen},
  pages     = {104 Seiten},
  year      = {2023},
  abstract  = {Das Einkaufen in Einkaufszentren oder Ladenstraßen ist f{\"u}r Menschen ohne Sehbehinderung eine selbstverst{\"a}ndliche T{\"a}tigkeit. F{\"u}r Menschen mit Sehbehinderung gibt es bis heute keine M{\"o}glichkeit, sich ohne Hilfe von Familienmitgliedern, Freund:innen oder Pflegepersonal in einem Einkaufszentrum zurechtzufinden. Genau dieses Problem l{\"o}st "NAVON.". Er ist ein intelligenter und smarter Blindenstock, welcher durch Ultraschalldistanzsensoren fr{\"u}hzeitig Hindernisse erkennt und die M{\"o}glichkeit bietet, den Betroffenen durch das Einkaufszentrum zu lotsen. Die Logik des Systems liegt innerhalb des Handgriffs, welcher die wichtigsten Einstellungen bzgl. Sprache und haptischer Bedienelemente steuert. Ebenfalls gibt er dem Betroffenen auch ein haptisches Feedback, um Hindernisse fr{\"u}hzeitig umgehen zu k{\"o}nnen. "NAVON." ist ein wichtiger Ansatz f{\"u}r eine neue Kategorie von Produkten und Blindenst{\"o}cken. Dar{\"u}ber hinaus birgt das Konzept auch weitere Potenziale f{\"u}r {\"o}ffentliche Geb{\"a}ude ({\"A}mter, Krankenh{\"a}user, etc..).},
  language  = {de}
}
@masterthesis{Outkina2023,
  type      = {Bachelor Thesis},
  author    = {Outkina, Ioulia},
  title     = {Kassandra : wetterbedingte Extremereignisse werden zunehmend die neue Realit{\"a}t bestimmen},
  publisher = {FH Aachen},
  address   = {Aachen},
  pages     = {253 Seiten},
  year      = {2023},
  abstract  = {Wetterbedingte Extremereignisse nehmen mit dem Klimawandel in vielen Regionen der Welt an Intensit{\"a}t und H{\"a}ufigkeit zu. Immer wieder unterstreichen tragische Krisenvorf{\"a}lle die Notwendigkeit der Aufkl{\"a}rung im Nachgang. Doch ausgerechnet wenn sich Leute {\"u}ber eins der aktuellsten und schwerwiegendsten Themen unserer heutigen Zeit informieren wollen, wird es daf{\"u}r keinen konsistenten Kanal in Deutschland geben. Kassandra bietet die M{\"o}glichkeit, sich verst{\"a}ndlich mit den Ereignissen und Missst{\"a}nden sachlich im Krisenbereich auseinanderzusetzen. Transparenz und Seriosit{\"a}t sind Schwerpunkte im qualitativ hochwertigen Bereich, die dabei von Wichtigkeit sind. Mit den Prinzipien des investigativen Journalismus schafft Kassandra als Onlineformat einen Denkanstoß, wie im Bereich der Krisenkommunikation eine Verbesserung stattfinden kann.},
  language  = {de}
}
@masterthesis{Palm2023,
  type      = {Bachelor Thesis},
  author    = {Palm, Kevin John},
  title     = {Viva sin Aqua : Konzeption einer Kampagne zum virtuellen Wasserbedarf},
  publisher = {FH Aachen},
  address   = {Aachen},
  pages     = {80 Seiten},
  year      = {2023},
  abstract  = {Den aktuellen Zustand unserer Welt positiv zu beeinflussen, ist ein {\"u}bergeordnetes Ziel, welches nur kollektiv als Gesellschaft erreicht werden kann. Das Einsparen von Ressourcen ist ein leichter Weg f{\"u}r jede einzelne Person, um ihren Beitrag f{\"u}r dieses Ziel zu leisten. Doch wie bewegt man die Bev{\"o}lkerung zum Sparen? Und was soll eingespart werden? Die Kampagne "Viva sin Agua" sensibilisiert f{\"u}r die Ressource Wasser und nutzt dabei den {\"o}ffentlichen Raum. Aufgekl{\"a}rt wird {\"u}ber das sogenannte virtuelle Wasser. Dieses f{\"a}llt in teilweise extremen Mengen f{\"u}r die Produktion jeglicher Konsumwaren an. Das Ziel der Kampagne ist das Kennzeichnen dieses Wasserverbrauchs direkt am Produkt {\"u}ber eigene Labels. Dadurch soll ein Bewusstsein f{\"u}r den kritischen Kontext geschaffen und das allgemeine Konsumverhalten nachhaltig ver{\"a}ndert werden.},
  language  = {de}
}
@masterthesis{Raring2023,
  type      = {Bachelor Thesis},
  author    = {Raring, Theresa},
  title     = {Multimar Wattforum : die Entwicklung eines neuen Erscheinungsbildes},
  publisher = {FH Aachen},
  address   = {Aachen},
  pages     = {85 Seiten},
  year      = {2023},
  abstract  = {Das Multimar Wattforum ist das gr{\"o}ßte Informationszentrum zum Thema Wattenmeer in Deutschland. Auf {\"u}ber 3000 Quadratmetern k{\"o}nnen große und kleine Besucher:innen eine interaktive Ausstellung {\"u}ber Wale, Watt und Weltnaturerbe bestaunen. Das Wattenmeer ist ein ganz besonderer Lebensraum und bietet vielen Lebewesen Zuflucht. Es wird durch die Gezeiten gepr{\"a}gt, bei Ebbe trocken und der Sonne ausgesetzt, bei Flut nass und salzig. Das neue Erscheinungsbild f{\"u}r das Multimar Wattforum soll die zentralen Werte und Alleinstellungsmerkmale hervorheben und dem Informationszentrum helfen, seiner Aufgabe als bildende, wissenschaftliche und sch{\"u}tzende Einrichtung gerecht zu werden. So wurde ein einheitliches und skalierbares Erscheinungsbild und eine flexible Bild- und Wortmarke entwickel},
  language  = {de}
}
@masterthesis{Riederer2023,
  type      = {Bachelor Thesis},
  author    = {Riederer, Estella Charlotte},
  title     = {ITFS : Redesign des Erscheinungsbildes des Internationalen Trickfilm-Festival Stuttgart},
  publisher = {FH Aachen},
  address   = {Aachen},
  pages     = {111 Seiten},
  year      = {2023},
  abstract  = {Film ab! Das Internationale Trickfilm-Festival Stuttgart ist seit 30 Jahren ein fester Bestandteil der internationalen Film- und Animations-Branche und z{\"a}hlt zu einer der renommiertesten Veranstaltungen. Das Festival ist ein Ort der Inspiration und des Austausches - die neusten Animationsfilme werden hier pr{\"a}sentiert, junge Talente entdeckt und gef{\"o}rdert. Im Fokus des neugestalteten Corporate Design steht die eigens entwickelte Schrift, welche den einzigartigen Charakter des Festivals widerspiegelt und so zum Trickfilm der Typografie wird. Das medien{\"u}bergreifende Erscheinungsbild, in animierter oder statischer Form, kommuniziert so die qualitativ hochwertigen Inhalte des Festivals. Durch die dynamische und plakative Gestaltung wird das Festival zu einem unvergesslichen Erlebnis f{\"u}r alle Besucher:innen.},
  language  = {de}
}
@masterthesis{Schlappa2023,
  type      = {Bachelor Thesis},
  author    = {Schlappa, Anja},
  title     = {Death \& Decay : a journey into deathly oddities},
  publisher = {FH Aachen},
  address   = {Aachen},
  pages     = {81 Seiten},
  year      = {2023},
  abstract  = {Wir werden alle eines Tages sterben. Obwohl - oder gerade weil - der Tod ein unausweichlicher Teil unseres Lebens ist, schreckt uns die Konversation {\"u}ber ihn und all seine Facetten ab, und die Furcht vor unserem eventuellen Ende bleibt bestehen. Jene Ehrfurcht hindert uns daran, das Ableben als mehr als nur den deprimierenden finalen Abschnitt unseres Seins zu betrachten. In ""Death \& Decay"" wird sich mit den weniger bekannten Seiten des Todes auseinandergesetzt, denn das Ende unserer Existenz ist nicht gleich das Ende unserer Geschichte. Von kultureller Symbolik bis zu Tod unter un{\"u}blichen Umst{\"a}nden - ""Death \& Decay"" nimmt Sie mit die Seiten des Todes kennenzulernen, die den meisten verborgen bleiben oder mit denen wir nie rechnen w{\"u}rden.},
  language  = {de}
}
@masterthesis{Tran2023,
  type      = {Bachelor Thesis},
  author    = {Tran, Hui Ming},
  title     = {Das Haus des Meeres : Entwicklung und Konzeption eines neuen Erscheinungsbildes f{\"u}r den Aqua Terra Zoo},
  publisher = {FH Aachen},
  address   = {Aachen},
  pages     = {115 Seiten},
  year      = {2023},
  abstract  = {Im Zentrum von Wien befindet sich in einem ehemaligen Flakturm aus dem 2. Weltkrieg, das Haus des Meeres. Auf ca 5000m2 beherbergen sie ca. 10.000 Tiere. Der Fokus liegt dabei auf die Unterwasserwelt und bietet einen ausgiebigen Einblick in die Welt der Meere. Das neue Erscheinungsbild positioniert die private und gemeinn{\"u}tzige Einrichtung sowohl als Ort des Zusammenkommens als auch der Wissensvermittlung. Dabei soll das Designkonzept vor dem Betreten des Zoos seine besondere Baukonstruktion aufzeigen und von Anfang an die Tiefe sowie Tiefenzonen der Meere einbeziehen. Damit distanzieren sie sich entscheidend von {\"a}hnlichen Institutionen. Inspiriert von der Teilung zwischen der Oberfl{\"a}che und dem Meer, entstand eine feine abstrakte Skala. Diese visualisiert den Meeresspiegel mit seiner Tiefe und dient medien{\"u}bergreifend als Orientierungshilfe.},
  language  = {de}
}
@incollection{Laack2023,
  author    = {Laack, Walter van},
  title     = {Nahtoderfahrungen, Sterben und Tod aus der Perspektive von Medizin, Naturwissenschaften und Philosophie},
  series = {Thanatologie im deutschsprachigen Raum - Interdisziplin{\"a}re Perspektiven},
  booktitle = {Thanatologie im deutschsprachigen Raum - Interdisziplin{\"a}re Perspektiven},
  editor    = {Ortmanns, Bruno and Brauers, Angelika},
  publisher = {Rediroma-Verlag},
  isbn      = {978-3-98527-661-5},
  pages     = {129 -- 139},
  year      = {2023},
  language  = {de}
}
@inproceedings{GrundAltherr2023,
  author    = {Grund, Raphael M. and Altherr, Lena},
  title     = {Development of an open source energy disaggregation tool for the home automation platform Home Assistant},
  series = {Tagungsband AALE 2023 : mit Automatisierung gegen den Klimawandel},
  booktitle = {Tagungsband AALE 2023 : mit Automatisierung gegen den Klimawandel},
  editor    = {Reiff-Stephan, J{\"o}rg and J{\"a}kel, Jens and Schwarz, Andr{\´e}},
  publisher = {le-tex publishing services GmbH},
  address   = {Leipzig},
  isbn      = {978-3-910103-01-6},
  doi       = {10.33968/2023.02},
  pages     = {11 -- 20},
  year      = {2023},
  abstract  = {In order to reduce energy consumption of homes, it is important to make transparent which devices consume how much energy. However, power consumption is often only monitored aggregated at the house energy meter. Disaggregating this power consumption into the contributions of individual devices can be achieved using Machine Learning. Our work aims at making state of the art disaggregation algorithms accessibe for users of the open source home automation platform Home Assistant.},
  language  = {en}
}
@misc{BragardHueningKowalewski2023,
  author    = {Bragard, Michael and H{\"u}ning, Felix and Kowalewski, Paul},
  title     = {Vorrichtung zur Relativlagenbestimmung [Offenlegungschrift]},
  year      = {2023},
  abstract  = {Die Erfindung betrifft eine Vorrichtung zur Bestimmung einer Relativlage zwischen einem feststehenden Teil und einem zu demselben in eine Bewegungsrichtung bewegbaren beweglichen Teil, wobei der feststehende Teil mit einem Wiegandsensor versehen ist, wobei der Wiegandsensor zwischen zwei gegenpolig zueinander ausgebildeten Permanentmagneten angeordnet ist und dass der bewegliche Teil eine Mehrzahl von beabstandet zueinander angeordneten Magnetisierungsstegen aus einem magnetisch leitenden Material aufweist, die in der Bewegungsrichtung zumindest eine gleich große Erstreckung aufweisen wie der Permanentmagnet, dass ein Abstand zwischen benachbarten Magnetisierungsstegen derart gew{\"a}hlt ist, dass in einer ersten Relativlage ein erster Permanentmagnet von einem der Magnetisierungsstege {\"u}berdeckt ist und ein zweiter Permanentmagnet nicht von einem der Magnetisierungsstege {\"u}berdeckt ist.},
  language  = {de}
}
@inproceedings{FunkeBeckmannStefanetal.2023,
  author    = {Funke, Harald and Beckmann, Nils and Stefan, Lukas and Keinz, Jan},
  title     = {Hydrogen combustor integration study for a medium range aircraft engine using the dry-low NOx "Micromix" combustion principle},
  series = {Proceedings of the ASME Turbo Expo 2023: Turbomachinery Technical Conference and Exposition. Volume 1: Aircraft Engine. Boston, Massachusetts, USA. June 26-30, 2023},
  booktitle = {Proceedings of the ASME Turbo Expo 2023: Turbomachinery Technical Conference and Exposition. Volume 1: Aircraft Engine. Boston, Massachusetts, USA. June 26-30, 2023},
  publisher = {ASME},
  address   = {New York},
  isbn      = {978-0-7918-8693-9},
  doi       = {10.1115/GT2023-102370},
  pages     = {12 Seiten},
  year      = {2023},
  abstract  = {The feasibility study presents results of a hydrogen combustor integration for a Medium-Range aircraft engine using the Dry-Low-NOₓ Micromix combustion principle. Based on a simplified Airbus A320-type flight mission, a thermodynamic performance model of a kerosene and a hydrogen-powered V2530-A5 engine is used to derive the thermodynamic combustor boundary conditions. A new combustor design using the Dry-Low NOx Micromix principle is investigated by slice model CFD simulations of a single Micromix injector for design and off-design operation of the engine. Combustion characteristics show typical Micromix flame shapes and good combustion efficiencies for all flight mission operating points. Nitric oxide emissions are significant below ICAO CAEP/8 limits. For comparison of the Emission Index (EI) for NOₓ emissions between kerosene and hydrogen operation, an energy (kerosene) equivalent Emission Index is used. A full 15° sector model CFD simulation of the combustion chamber with multiple Micromix injectors including inflow homogenization and dilution and cooling air flows investigates the combustor integration effects, resulting NOₓ emission and radial temperature distributions at the combustor outlet. The results show that the integration of a Micromix hydrogen combustor in actual aircraft engines is feasible and offers, besides CO₂ free combustion, a significant reduction of NOₓ emissions compared to kerosene operation.},
  language  = {en}
}
@inproceedings{LahrsKrisamHerrmann2023,
  author    = {Lahrs, Lennart and Krisam, Pierre and Herrmann, Ulf},
  title     = {Envisioning a collaborative energy system planning platform for the energy transition at the district level},
  series = {The 36th International Conference on Efficiency, Cost, Optimization, Simulation and Environmental Impact of Energy Systems},
  booktitle = {The 36th International Conference on Efficiency, Cost, Optimization, Simulation and Environmental Impact of Energy Systems},
  publisher = {Procedings of ECOS 2023},
  doi       = {10.52202/069564-0284},
  pages     = {3163 -- 3170},
  year      = {2023},
  abstract  = {Residential and commercial buildings account for more than one-third of global energy-related greenhouse gas emissions. Integrated multi-energy systems at the district level are a promising way to reduce greenhouse gas emissions by exploiting economies of scale and synergies between energy sources. Planning district energy systems comes with many challenges in an ever-changing environment. Computational modelling established itself as the state-of-the-art method for district energy system planning. Unfortunately, it is still cumbersome to combine standalone models to generate insights that surpass their original purpose. Ideally, planning processes could be solved by using modular tools that easily incorporate the variety of competing and complementing computational models. Our contribution is a vision for a collaborative development and application platform for multi-energy system planning tools at the district level. We present challenges of district energy system planning identified in the literature and evaluate whether this platform can help to overcome these challenges. Further, we propose a toolkit that represents the core technical elements of the platform. Lastly, we discuss community management and its relevance for the success of projects with collaboration and knowledge sharing at their core.},
  language  = {en}
}
@inproceedings{SchulteSchwagerNoureldinetal.2023,
  author    = {Schulte, Jonas and Schwager, Christian and Noureldin, Kareem and May, Martin and Teixeira Boura, Cristiano Jos{\´e} and Herrmann, Ulf},
  title     = {Gradient controlled startup procedure of a molten-salt power-to-heat energy storage plant based on dynamic process simulation},
  series = {SolarPACES: Solar Power \& Chemical Energy Systems},
  booktitle = {SolarPACES: Solar Power \& Chemical Energy Systems},
  number    = {2815 / 1},
  publisher = {AIP conference proceedings / American Institute of Physics},
  address   = {Melville, NY},
  isbn      = {978-0-7354-4623-6},
  issn      = {1551-7616 (online)},
  doi       = {10.1063/5.0148741},
  pages     = {9 Seiten},
  year      = {2023},
  abstract  = {The integration of high temperature thermal energy storages into existing conventional power plants can help to reduce the CO2 emissions of those plants and lead to lower capital expenditures for building energy storage systems, due to the use of synergy effects [1]. One possibility to implement that, is a molten salt storage system with a powerful power-to-heat unit. This paper presents two possible control concepts for the startup of the charging system of such a facility. The procedures are implemented in a detailed dynamic process model. The performance and safety regarding the film temperatures at heat transmitting surfaces are investigated in the process simulations. To improve the accuracy in predicting the film temperatures, CFD simulations of the electrical heater are carried out and the results are merged with the dynamic model. The results show that both investigated control concepts are safe regarding the temperature limits. The gradient controlled startup performed better than the temperature-controlled startup. Nevertheless, there are several uncertainties that need to be investigated further.},
  language  = {en}
}
@inproceedings{SchwagerAngeleSchwarzboezletal.2023,
  author    = {Schwager, Christian and Angele, Florian and Schwarzb{\"o}zl, Peter and Teixeira Boura, Cristiano Jos{\´e} and Herrmann, Ulf},
  title     = {Model predictive assistance for operational decision making in molten salt receiver systems},
  series = {SolarPACES: Solar Power \& Chemical Energy Systems},
  booktitle = {SolarPACES: Solar Power \& Chemical Energy Systems},
  number    = {2815 / 1},
  publisher = {AIP conference proceedings / American Institute of Physics},
  address   = {Melville, NY},
  isbn      = {978-0-7354-4623-6},
  issn      = {1551-7616 (online)},
  doi       = {10.1063/5.0151514},
  pages     = {8 Seiten},
  year      = {2023},
  abstract  = {Despite the challenges of pioneering molten salt towers (MST), it remains the leading technology in central receiver power plants today, thanks to cost effective storage integration and high cost reduction potential. The limited controllability in volatile solar conditions can cause significant losses, which are difficult to estimate without comprehensive modeling [1]. This paper presents a Methodology to generate predictions of the dynamic behavior of the receiver system as part of an operating assistance system (OAS). Based on this, it delivers proposals if and when to drain and refill the receiver during a cloudy period in order maximize the net yield and quantifies the amount of net electricity gained by this. After prior analysis with a detailed dynamic two-phase model of the entire receiver system, two different reduced modeling approaches where developed and implemented in the OAS. A tailored decision algorithm utilizes both models to deliver the desired predictions efficiently and with appropriate accuracy.},
  language  = {en}
}
@inproceedings{ChircuCzarneckiFriedmannetal.2023,
  author    = {Chircu, Alina and Czarnecki, Christian and Friedmann, Daniel and Pomaskow, Johanna and Sultanow, Eldar},
  title     = {Towards a Digital Twin of Society},
  series = {Proceedings of the 56th Hawaii International Conference on System Sciences 2023},
  booktitle = {Proceedings of the 56th Hawaii International Conference on System Sciences 2023},
  publisher = {University of Hawai'i},
  address   = {Honolulu},
  isbn      = {978-0-9981331-6-4},
  pages     = {6748 -- 6757},
  year      = {2023},
  abstract  = {This paper describes the potential for developing a digital twin of society- a dynamic model that can be used to observe, analyze, and predict the evolution of various societal aspects. Such a digital twin can help governmental agencies and policy makers in interpreting trends, understanding challenges, and making decisions regarding investments or policies necessary to support societal development and ensure future prosperity. The paper reviews related work regarding the digital twin paradigm and its applications. The paper presents a motivating case study- an analysis of opportunities and challenges faced by the German federal employment agency, Bundesagentur f¨ur Arbeit (BA), proposes solutions using digital twins, and describes initial proofs of concept for such solutions.},
  language  = {en}
}
@book{DrummScheuermannWeidner2023,
  author    = {Drumm, Christian and Scheuermann, Bernd and Weidner, Stefan},
  title     = {Einstieg in SAP S/4HANA® : Gesch{\"a}ftsprozesse, Anwendungen, Zusammenh{\"a}nge - Erkl{\"a}rt am Beispielunternehmen Global Bike},
  publisher = {Rheinwerk Verlag},
  address   = {Bonn},
  isbn      = {9783836281560 (Print)},
  pages     = {587 Seiten},
  year      = {2023},
  abstract  = {Dieser verst{\"a}ndliche Einstieg in SAP S/4HANA f{\"u}hrt Sie anhand des Beispielunternehmens Global Bike durch die zentralen Abl{\"a}ufe in Vertrieb, Einkauf, Rechnungswesen, Produktion und Lagerverwaltung. Sie werden mit den betriebswirtschaftlichen Grundlagen, den relevanten Organisationsstrukturen und Stammdaten sowie den Prozessen vertraut gemacht. Mithilfe von Praxisbeispielen und Fallstudien sind Sie schon bald SAP-S/4HANA-Profi - f{\"u}r mehr Erfolg in Studium und Beruf!},
  language  = {de}
}
@article{ŠakićMarinkovićButenwegetal.2023,
  author    = {Šakić, Bogdan and Marinković, Marko and Butenweg, Christoph and Klinkel, Sven},
  title     = {Influence of slab deflection on the out-of-plane capacity of unreinforced masonry partition walls},
  series = {Engineering Structures},
  volume    = {276},
  journal   = {Engineering Structures},
  editor    = {Yang, J.},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0141-0296},
  doi       = {10.1016/j.engstruct.2022.115342},
  year      = {2023},
  abstract  = {Severe damage of non-structural elements is noticed in previous earthquakes, causing high economic losses and posing a life threat for the people. Masonry partition walls are one of the most commonly used non-structural elements. Therefore, their behaviour under earthquake loading in out-of-plane (OOP) direction is investigated by several researches in the past years. However, none of the existing experimental campaigns or analytical approaches consider the influence of prior slab deflection on OOP response of partition walls. Moreover, none of the existing construction techniques for the connection of partition walls with surrounding reinforced concrete (RC) is investigated for the combined slab deflection and OOP loading. However, the inevitable time-dependent behaviour of RC slabs leads to high values of final slab deflections which can further influence boundary conditions of partition walls. Therefore, a comprehensive study on the influence of slab deflection on the OOP capacity of masonry partitions is conducted. In the first step, experimental tests are carried out. Results of experimental tests are further used for the calibration of the numerical model employed for a parametric study. Based on the results, behaviour under combined loading for different construction techniques is explained. The results show that slab deflection leads either to severe damage or to a high reduction of OOP capacity. Existing practical solutions do not account for these effects. In this contribution, recommendations to overcome the problems of combined slab deflection and OOP loading on masonry partition walls are given. Possible interaction of in-plane (IP) loading, with the combined slab deflection and OOP loading on partition walls, is not investigated in this study.},
  language  = {en}
}
@article{NiedermeierPennerUsherovichetal.2023,
  author    = {Niedermeier, Jana and Penner, Crystal and Usherovich, Samuel and B{\´e}langer-Champagne, Camille and Paulßen, Elisabeth and Cornelia, Hoehr},
  title     = {Optical Fibers as Dosimeter Detectors for Mixed Proton/Neutron Fields - A Biological Dosimeter},
  series = {electronics},
  volume    = {12},
  journal   = {electronics},
  number    = {2},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2079-9292},
  doi       = {10.3390/electronics12020324},
  pages     = {11 Seiten},
  year      = {2023},
  abstract  = {In recent years, proton therapy has gained importance as a cancer treatment modality due to its conformality with the tumor and the sparing of healthy tissue. However, in the interaction of the protons with the beam line elements and patient tissues, potentially harmful secondary neutrons are always generated. To ensure that this neutron dose is as low as possible, treatment plans could be created to also account for and minimize the neutron dose. To monitor such a treatment plan, a compact, easy to use, and inexpensive dosimeter must be developed that not only measures the physical dose, but which can also distinguish between proton and neutron contributions. To that end, plastic optical fibers with scintillation materials (Gd₂O₂S:Tb, Gd₂O₂S:Eu, and YVO₄:Eu) were irradiated with protons and neutrons. It was confirmed that sensors with different scintillation materials have different sensitivities to protons and neutrons. A combination of these three scintillators can be used to build a detector array to create a biological dosimeter.},
  language  = {en}
}
@article{RuebbelkeVoegeleGrajewskietal.2023,
  author    = {R{\"u}bbelke, Dirk and V{\"o}gele, Stefan and Grajewski, Matthias and Zobel, Luzy},
  title     = {Cross border adjustment mechanism: Initial data for the assessment of hydrogen-based steel production},
  series = {Data in Brief},
  volume    = {47},
  journal   = {Data in Brief},
  number    = {Article 108907},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {2352-3409},
  doi       = {10.1016/j.dib.2023.108907},
  pages     = {1 -- 5},
  year      = {2023},
  abstract  = {Ambitious climate targets affect the competitiveness of industries in the international market. To prevent such industries from moving to other countries in the wake of increased climate protection efforts, cost adjustments may become necessary. Their design requires knowledge of country-specific production costs. Here, we present country-specific cost figures for different production routes of steel, paying particular attention to transportation costs. The data can be used in floor price models aiming to assess the competitiveness of different steel production routes in different countries (R{\"u}bbelke, 2022).},
  language  = {en}
}
@article{HaegerGrankinWagner2023,
  author    = {Haeger, Gerrit and Grankin, Alina and Wagner, Michaela},
  title     = {Construction of an Aspergillus oryzae triple amylase deletion mutant as a chassis to evaluate industrially relevant amylases using multiplex CRISPR/Cas9 editing technology},
  series = {Applied Research},
  journal   = {Applied Research},
  number    = {Early View},
  publisher = {Wiley-VCH},
  issn      = {2702-4288},
  doi       = {10.1002/appl.202200106},
  pages     = {1 -- 15},
  year      = {2023},
  abstract  = {Aspergillus oryzae is an industrially relevant organism for the secretory production of heterologous enzymes, especially amylases. The activities of potential heterologous amylases, however, cannot be quantified directly from the supernatant due to the high background activity of native α-amylase. This activity is caused by the gene products of amyA, amyB, and amyC. In this study, an in vitro CRISPR/Cas9 system was established in A. oryzae to delete these genes simultaneously. First, pyrG of A. oryzae NSAR1 was mutated by exploiting NHEJ to generate a counter-selection marker. Next, all amylase genes were deleted simultaneously by co-transforming a repair template carrying pyrG of Aspergillus nidulans and flanking sequences of amylase gene loci. The rate of obtained triple knock-outs was 47\%. We showed that triple knockouts do not retain any amylase activity in the supernatant. The established in vitro CRISPR/Cas9 system was used to achieve sequence-specific knock-in of target genes. The system was intended to incorporate a single copy of the gene of interest into the desired host for the development of screening methods. Therefore, an integration cassette for the heterologous Fpi amylase was designed to specifically target the amyB locus. The site-specific integration rate of the plasmid was 78\%, with exceptional additional integrations. Integration frequency was assessed via qPCR and directly correlated with heterologous amylase activity. Hence, we could compare the efficiency between two different signal peptides. In summary, we present a strategy to exploit CRISPR/Cas9 for gene mutation, multiplex knock-out, and the targeted knock-in of an expression cassette in A. oryzae. Our system provides straightforward strain engineering and paves the way for development of fungal screening systems.},
  language  = {en}
}