@article{MulhernBialonskiKantz2015, author = {Mulhern, Colm and Bialonski, Stephan and Kantz, Holger}, title = {Extreme events due to localization of energy}, series = {Physical Review E}, volume = {91}, journal = {Physical Review E}, number = {1}, issn = {2470-0053}, doi = {10.1103/PhysRevE.91.012918}, pages = {012918}, year = {2015}, language = {en} } @article{GeierLehnertzBialonski2015, author = {Geier, Christian and Lehnertz, Klaus and Bialonski, Stephan}, title = {Time-dependent degree-degree correlations in epileptic brain networks: from assortative to dissortative mixing}, series = {Frontiers in Human Neuroscience}, journal = {Frontiers in Human Neuroscience}, publisher = {Frontiers Research Foundation}, address = {Lausanne}, issn = {1662-5161}, doi = {10.3389/fnhum.2015.00462}, year = {2015}, language = {en} } @article{GeierBialonskiElgeretal.2015, author = {Geier, Christian and Bialonski, Stephan and Elger, Christian E. and Lehnertz, Klaus}, title = {How important is the seizure onset zone for seizure dynamics?}, series = {Seizure}, volume = {25}, journal = {Seizure}, issn = {1059-1311}, doi = {10.1016/j.seizure.2014.10.013}, pages = {160 -- 166}, year = {2015}, language = {en} } @article{LehnertzAnsmannBialonskietal.2014, author = {Lehnertz, Klaus and Ansmann, Gerrit and Bialonski, Stephan and Dickten, Henning and Geier, Christian and Porz, Stephan}, title = {Evolving networks in the human epileptic brain}, series = {Physica D: Nonlinear Phenomena}, volume = {267}, journal = {Physica D: Nonlinear Phenomena}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0167-2789}, doi = {10.1016/j.physd.2013.06.009}, pages = {7 -- 15}, year = {2014}, abstract = {Network theory provides novel concepts that promise an improved characterization of interacting dynamical systems. Within this framework, evolving networks can be considered as being composed of nodes, representing systems, and of time-varying edges, representing interactions between these systems. This approach is highly attractive to further our understanding of the physiological and pathophysiological dynamics in human brain networks. Indeed, there is growing evidence that the epileptic process can be regarded as a large-scale network phenomenon. We here review methodologies for inferring networks from empirical time series and for a characterization of these evolving networks. We summarize recent findings derived from studies that investigate human epileptic brain networks evolving on timescales ranging from few seconds to weeks. We point to possible pitfalls and open issues, and discuss future perspectives.}, language = {en} } @article{KuhnertBialonskiNoenningetal.2013, author = {Kuhnert, Marie-Therese and Bialonski, Stephan and Noenning, Nina and Mai, Heinke and Hinrichs, Hermann and Helmstaedter, Christoph and Lehnertz, Klaus}, title = {Incidental and intentional learning of verbal episodic material differentially modifies functional brain networks}, series = {Plos one}, volume = {8}, journal = {Plos one}, number = {11}, publisher = {PLOS}, address = {San Francisco}, doi = {10.1371/journal.pone.0080273}, pages = {e80273}, year = {2013}, abstract = {Learning- and memory-related processes are thought to result from dynamic interactions in large-scale brain networks that include lateral and mesial structures of the temporal lobes. We investigate the impact of incidental and intentional learning of verbal episodic material on functional brain networks that we derive from scalp-EEG recorded continuously from 33 subjects during a neuropsychological test schedule. Analyzing the networks' global statistical properties we observe that intentional but not incidental learning leads to a significantly increased clustering coefficient, and the average shortest path length remains unaffected. Moreover, network modifications correlate with subsequent recall performance: the more pronounced the modifications of the clustering coefficient, the higher the recall performance. Our findings provide novel insights into the relationship between topological aspects of functional brain networks and higher cognitive functions.}, language = {en} } @article{BialonskiLehnertz2013, author = {Bialonski, Stephan and Lehnertz, Klaus}, title = {Assortative mixing in functional brain networks during epileptic seizures}, series = {Chaos: An Interdisciplinary Journal of Nonlinear Science}, volume = {23}, journal = {Chaos: An Interdisciplinary Journal of Nonlinear Science}, number = {3}, doi = {10.1063/1.4821915}, pages = {033139}, year = {2013}, language = {en} } @article{SchindlerBialonskiHorstmannetal.2008, author = {Schindler, Kaspar A. and Bialonski, Stephan and Horstmann, Marie-Therese and Elger, Christian E. and Lehnertz, Klaus}, title = {Evolving functional network properties and synchronizability during human epileptic seizures}, series = {Chaos: An Interdisciplinary Journal of Nonlinear Science}, volume = {18}, journal = {Chaos: An Interdisciplinary Journal of Nonlinear Science}, number = {3}, issn = {1089-7682}, doi = {10.1063/1.2966112}, pages = {033119}, year = {2008}, language = {en} } @article{BialonskiAllefeldWellmeretal.2008, author = {Bialonski, Stephan and Allefeld, C. and Wellmer, J. and Elger, C. and Lehnertz, K.}, title = {An approach to identify synchronization clusters within the epileptic network}, series = {Klinische Neurophysiologie}, volume = {39}, journal = {Klinische Neurophysiologie}, number = {1}, doi = {10.1055/s-2008-1072881}, pages = {A79}, year = {2008}, language = {en} } @article{BialonskiSchindlerElgeretal.2008, author = {Bialonski, Stephan and Schindler, K. and Elger, C. E. and Lehnertz, Klaus}, title = {Lateralized characteristics of the evolution of EEG correlation during focal onset seizures: a mechanism to prevent secondary generalization?}, series = {Epilepsia}, volume = {49}, journal = {Epilepsia}, issn = {0013-9580}, pages = {11 -- 11}, year = {2008}, abstract = {Rationale: Previous studies [Topolnik et al., Cereb Cortex 2003; 13: 883; Schindler et al., Brain 2007; 130: 65] indicate that the termination of focal onset seizures may be causally related to an increase of global neuronal correlation during the second half of the seizures. This increase was observed to occur earlier in complex partial seizures than in secondarily generalized seizures. We here address the question whether such an increase of neuronal correlation prior to seizure end is indeed a global phenomenon, involving both hemispheres or whether there are side-specific differences. Methods: We analyzed 20 focal onset seizures (10 complex partial, 10 secondarily generalized seizures) recorded in 13 patients who underwent presurgical evaluation of focal epilepsies of different origin. EEG was recorded intracranially from bilaterally implanted subdural strip and intrahippocampal depth electrodes. Utilizing a moving window approach, we investigated the evolution of the maximum cross correlation for all channel combinations during seizures. For each moving window the mean value of the maximum cross correlation (MCC) between all electrode contacts was computed separately for each hemisphere. After normalization of seizure durations, MCC values of the ipsi- and contralateral hemisphere for all seizures were determined. Results: We observed that the MCC of the contralateral hemisphere in complex partial seizures increased during the first half of the seizure, whereas, for the same time interval, the MCC of the ipsilateral hemisphere even declined below the level of the pre-seizure period. In contrast, no significant differences between both hemispheres could be observed for secondarily generalized seizures where both hemispheres showed a simultaneous increase of MCC during the second half of the seizures. The level of MCC for the contralateral hemisphere was higher for complex partial seizures than for secondarily generalized seizures during the first half of the seizure. Conclusions: Our findings indicate that there are indeed lateralized differences in the evolution of global neuronal correlation during complex partial and secondarily generalized seizures. The observed contralateral increase of neuronal correlation during complex partial seizures might indicate an emerging self-organizing mechanism for preventing the spread of seizure activity.}, language = {en} } @article{AllefeldBialonski2007, author = {Allefeld, Carsten and Bialonski, Stephan}, title = {Detecting synchronization clusters in multivariate time series via coarse-graining of Markov chains}, series = {Physical Review E}, volume = {76}, journal = {Physical Review E}, number = {6}, issn = {2470-0053}, doi = {10.1103/PhysRevE.76.066207}, pages = {066207}, year = {2007}, language = {en} } @article{LehnertzMormannOsterhageetal.2007, author = {Lehnertz, Klaus and Mormann, Florian and Osterhage, Hannes and Andy, M{\"u}ller and Prusseit, Jens and Chernihovskyi, Anton and Staniek, Matth{\"a}us and Krug, Dieter and Bialonski, Stephan and Elger, Christian E.}, title = {State-of-the-art of seizure prediction}, series = {Journal of Clinical Neurophysiology}, volume = {24}, journal = {Journal of Clinical Neurophysiology}, number = {2}, issn = {1537-1603}, doi = {10.1097/WNP.0b013e3180336f16}, pages = {147 -- 153}, year = {2007}, language = {en} } @article{BialonskiLehnertz2006, author = {Bialonski, Stephan and Lehnertz, Klaus}, title = {Identifying phase synchronization clusters in spatially extended dynamical systems}, series = {Physical Review E}, volume = {74}, journal = {Physical Review E}, number = {5}, issn = {2470-0053}, doi = {10.1103/PhysRevE.74.051909}, pages = {051909}, year = {2006}, language = {en} } @article{BialonskiWellmerElgeretal.2006, author = {Bialonski, Stephan and Wellmer, J{\"o}rg and Elger, Christian E. and Lehnertz, Klaus}, title = {Interictal focus localization in neocortical lesional epilepsies with synchronization cluster analysis}, series = {Epilepsia}, volume = {47}, journal = {Epilepsia}, issn = {0013-9580}, pages = {36}, year = {2006}, language = {en} } @article{RichterBraunsteinWinnardetal.2017, author = {Richter, Charlotte and Braunstein, Bjoern and Winnard, Andrew and Nasser, Mona and Weber, T.}, title = {Human Biomechanical and Cardiopulmonary Responses to Partial Gravity - A Systematic Review}, series = {Frontiers in physiology}, journal = {Frontiers in physiology}, number = {8, article 583}, doi = {10.3389/fphys.2017.00583}, pages = {22 Seiten}, year = {2017}, language = {en} } @article{JildehWagnerSchoening2021, author = {Jildeh, Zaid B. and Wagner, Patrick H. and Sch{\"o}ning, Michael Josef}, title = {Sterilization of Objects, Products, and Packaging Surfaces and Their Characterization in Different Fields of Industry: The Status in 2020}, series = {physica status solidi (a) applications and materials science}, volume = {218}, journal = {physica status solidi (a) applications and materials science}, number = {13}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1862-6319}, doi = {10.1002/pssa.202000732}, pages = {27 Seiten}, year = {2021}, abstract = {The treatment method to deactivate viable microorganisms from objects or products is termed sterilization. There are multiple forms of sterilization, each intended to be applied for a specific target, which depends on—but not limited to—the thermal, physical, and chemical stability of that target. Herein, an overview on the currently used sterilization processes in the global market is provided. Different sterilization techniques are grouped under a category that describes the method of treatment: radiation (gamma, electron beam, X-ray, and ultraviolet), thermal (dry and moist heat), and chemical (ethylene oxide, ozone, chlorine dioxide, and hydrogen peroxide). For each sterilization process, the typical process parameters as defined by regulations and the mode of antimicrobial activity are summarized. Finally, the recommended microorganisms that are used as biological indicators to validate sterilization processes in accordance with the rules that are established by various regulatory agencies are summarized.}, language = {en} } @article{MolinnusDrinicIkenetal.2021, author = {Molinnus, Denise and Drinic, Aleksander and Iken, Heiko and Kr{\"o}ger, Nadja and Zinser, Max and Smeets, Ralf and K{\"o}pf, Marius and Kopp, Alexander and Sch{\"o}ning, Michael Josef}, title = {Towards a flexible electrochemical biosensor fabricated from biocompatible Bombyx mori silk}, series = {Biosensors and Bioelectronics}, volume = {183}, journal = {Biosensors and Bioelectronics}, number = {Art. 113204}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0956-5663}, doi = {10.1016/j.bios.2021.113204}, year = {2021}, language = {en} } @article{NguyenXuanRabczukNguyenThoietal.2011, author = {Nguyen-Xuan, H. and Rabczuk, T. and Nguyen-Thoi, T. and Tran, Thanh Ngoc and Nguyen-Thanh, N.}, title = {Computation of limit and shakedown loads using a node-based smoothed finite element method}, series = {International Journal for Numerical Methods in Engineering}, volume = {90}, journal = {International Journal for Numerical Methods in Engineering}, number = {3}, publisher = {Wiley}, address = {Weinheim}, issn = {1097-0207}, doi = {10.1002/nme.3317}, pages = {287 -- 310}, year = {2011}, abstract = {This paper presents a novel numerical procedure for computing limit and shakedown loads of structures using a node-based smoothed FEM in combination with a primal-dual algorithm. An associated primal-dual form based on the von Mises yield criterion is adopted. The primal-dual algorithm together with a Newton-like iteration are then used to solve this associated primal-dual form to determine simultaneously both approximate upper and quasi-lower bounds of the plastic collapse limit and the shakedown limit. The present formulation uses only linear approximations and its implementation into finite element programs is quite simple. Several numerical examples are given to show the reliability, accuracy, and generality of the present formulation compared with other available methods.}, language = {en} } @article{YoshinobuSchoening2021, author = {Yoshinobu, Tatsuo and Sch{\"o}ning, Michael Josef}, title = {Light-addressable potentiometric sensors (LAPS) for cell monitoring and biosensing}, series = {Current Opinion in Electrochemistry}, journal = {Current Opinion in Electrochemistry}, number = {In Press, Journal Pre-proof}, publisher = {Elsevier}, address = {Amsterdam}, issn = {2451-9103}, doi = {10.1016/j.coelec.2021.100727}, year = {2021}, language = {en} } @article{JablonskiMuenstermannNorketal.2021, author = {Jablonski, Melanie and M{\"u}nstermann, Felix and Nork, Jasmina and Molinnus, Denise and Muschallik, Lukas and Bongaerts, Johannes and Wagner, Torsten and Keusgen, Michael and Siegert, Petra and Sch{\"o}ning, Michael Josef}, title = {Capacitive field-effect biosensor applied for the detection of acetoin in alcoholic beverages and fermentation broths}, series = {physica status solidi (a) applications and materials science}, volume = {218}, journal = {physica status solidi (a) applications and materials science}, number = {13}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1862-6319}, doi = {10.1002/pssa.202000765}, pages = {7 Seiten}, year = {2021}, abstract = {An acetoin biosensor based on a capacitive electrolyte-insulator-semiconductor (EIS) structure modified with the enzyme acetoin reductase, also known as butane-2,3-diol dehydrogenase (Bacillus clausii DSM 8716ᵀ), is applied for acetoin detection in beer, red wine, and fermentation broth samples for the first time. The EIS sensor consists of an Al/p-Si/SiO₂/Ta₂O₅ layer structure with immobilized acetoin reductase on top of the Ta₂O₅ transducer layer by means of crosslinking via glutaraldehyde. The unmodified and enzyme-modified sensors are electrochemically characterized by means of leakage current, capacitance-voltage, and constant capacitance methods, respectively.}, language = {en} } @article{WertIkenSchoeningetal.2021, author = {Wert, Stefan and Iken, Heiko and Sch{\"o}ning, Michael Josef and Matysik, Frank-Michael}, title = {Development of a temperature-pulse enhanced electrochemical glucose biosensor and characterization of its stability via scanning electrochemical microscopy}, series = {Electroanalysis}, journal = {Electroanalysis}, number = {Early View}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1521-4109}, doi = {10.1002/elan.202100089}, year = {2021}, abstract = {Glucose oxidase (GOx) is an enzyme frequently used in glucose biosensors. As increased temperatures can enhance the performance of electrochemical sensors, we investigated the impact of temperature pulses on GOx that was drop-coated on flattened Pt microwires. The wires were heated by an alternating current. The sensitivity towards glucose and the temperature stability of GOx was investigated by amperometry. An up to 22-fold increase of sensitivity was observed. Spatially resolved enzyme activity changes were investigated via scanning electrochemical microscopy. The application of short (<100 ms) heat pulses was associated with less thermal inactivation of the immobilized GOx than long-term heating.}, language = {en} }