@inproceedings{ValeroBung2016, author = {Valero, Daniel and Bung, Daniel Bernhard}, title = {Interfacial velocity estimation in highly aerated stepped spillway flows with a single tip fibre optical probe and Artificial Neural Networks}, series = {6th IAHR International Junior Researcher and Engineer Workshop on Hydraulic Structures, May 30th to June 1st 2016. L{\"u}beck, Germany}, booktitle = {6th IAHR International Junior Researcher and Engineer Workshop on Hydraulic Structures, May 30th to June 1st 2016. L{\"u}beck, Germany}, doi = {10.15142/T3Q590}, pages = {13 Seiten}, year = {2016}, abstract = {Air-water flows can be found in different engineering applications: from nuclear engineering to huge hydraulic structures. In this paper, a single tip fibre optical probe has been used to record high frequency (over 1 MHz) phase functions at different locations of a stepped spillway. These phase functions have been related to the interfacial velocities by means of Artificial Neural Networks (ANN) and the measurements of a classical double tip conductivity probe. Special attention has been put to the input selection and the ANN dimensions. Finally, ANN have shown to be able to link the signal rising times and plateau shapes to the air-water interfacial velocity.}, language = {en} } @article{WollertBooke2016, author = {Wollert, J{\"o}rg and Booke, Andreas}, title = {IoT von der Stange}, series = {elektronik}, journal = {elektronik}, number = {21 (2016)}, publisher = {WEKA-Fachmedien}, address = {M{\"u}nchen}, pages = {30 -- 37}, year = {2016}, abstract = {Heute sollte am besten jedes Ger{\"a}t in die große Rechnerwolke eingebettet werden. Doch so einfach ist das nicht, denn Cloud ist viel mehr als nur das Internet der Dinge. Als Anwender muss man sich also fragen, welche Dienste man m{\"o}chte und welchem Anbieter man sein Vertrauen schenkt.}, language = {de} } @inproceedings{KolditzAlbinAlbrachtetal.2016, author = {Kolditz, Melanie and Albin, Thivaharan and Albracht, Kirsten and Br{\"u}ggemann, Gert-Peter and Abel, Dirk}, title = {Isokinematic leg extension training with an industrial robot}, series = {6th IEEE RAS/EMBS International Conference on Biomedical Robotics and Biomechatronics (BioRob) June 26-29, 2016. UTown, Singapore}, booktitle = {6th IEEE RAS/EMBS International Conference on Biomedical Robotics and Biomechatronics (BioRob) June 26-29, 2016. UTown, Singapore}, doi = {10.1109/BIOROB.2016.7523750}, pages = {950 -- 955}, year = {2016}, language = {de} } @inproceedings{BeckerHoefkenSchuetzetal.2016, author = {Becker, Sebastian and H{\"o}fken, Hans-Wilhelm and Sch{\"u}tz, Philip and Schuba, Marko}, title = {IT-forensische Erkennung modifizierter Android-Apps}, series = {Proceedings of DACH Security 2016, Klagenfurt, Austria, September 2016}, booktitle = {Proceedings of DACH Security 2016, Klagenfurt, Austria, September 2016}, editor = {Schartner, P.}, pages = {120 -- 125}, year = {2016}, abstract = {Malware auf Smartphones ist ein Problem, dem auch Strafverfolgungsbeh{\"o}rden immer h{\"a}ufiger gegen{\"u}berstehen. Insbesondere Telefone, bei denen potentiell schadhafte Apps zu einem finanziellen Schaden gef{\"u}hrt haben, finden sich auf den Schreibtischen der Polizei wieder. Dabei m{\"u}ssen die Ermittler m{\"o}glichst schnell und gezielt erkennen k{\"o}nnen, ob eine App tats{\"a}chlich schadhaft manipuliert wurde, was manipuliert wurde und mit wem die App kommuniziert. Klassische Malware-Erkennungsverfahren helfen zwar bei der generellen Erkennung schadhafter Software, sind aber f{\"u}r die polizeiliche Praxis nicht geeignet. Dieses Paper stellt ein Programm vor, welches gerade die forensischen Fragestellungen ber{\"u}cksichtigt und so f{\"u}r den Einsatz in der Strafverfolgung in Frage kommt.}, language = {de} } @incollection{Streit2016, author = {Streit, Wilfried}, title = {Kalkulation}, series = {Zahlentafeln f{\"u}r den Baubetrieb}, booktitle = {Zahlentafeln f{\"u}r den Baubetrieb}, edition = {9., {\"u}berarb. und aktual. Aufl.}, publisher = {Springer Vieweg}, address = {Wiesbaden}, isbn = {978-3-658-02838-1 (Online)}, doi = {10.1007/978-3-658-02838-1_13}, pages = {1391 -- 1501}, year = {2016}, abstract = {Das Kapitel behandelt die Kosten- und Preisermittlung, die Kostenvorgabe und Kostenkontrolle. Der Angebotspreis wird aufgeschl{\"u}sselt in die Einzelkosten der Teilleistungen, die Baustellengemeinkosten, die Allgemeinen Gesch{\"a}ftskosten und einen Zuschlag f{\"u}r Wagnis und Gewinn. Auf der Basis der Angebotskalkulation werden die Vorgaben f{\"u}r die Kostenkontrolle entwickelt.}, language = {de} } @techreport{DammAnthrakidisFend2016, author = {Damm, Marc Andr{\´e} and Anthrakidis, Anette and Fend, Thomas}, title = {Keramische Porenk{\"o}rpersysteme als SCR-Mischer und Hydrolysekatalysator : BMBF-Projekt: Hydromix : Schlussbericht : Laufzeit: 01.10.2011 bis 31.03.2015}, address = {Aachen}, pages = {30 Seiten : Illustrationen, Diagramme}, year = {2016}, language = {de} } @inproceedings{BagheriSchleupenDahmannetal.2016, author = {Bagheri, Mohsen and Schleupen, Josef and Dahmann, Peter and Kallweit, Stephan}, title = {Kletternde Wartungsplattform f{\"u}r die wetterunabh{\"a}ngige Instandhaltung von Rotorbl{\"a}ttern an Windenergieanlagen - SMART}, series = {AKIDA 2016 Aachener Kolloquium f{\"u}r Instandhaltung, Diagnose und Anlagen{\"u}berwachung (AKIDA) am 15. und 16.11.2016, Technologiezentrum Aachen}, booktitle = {AKIDA 2016 Aachener Kolloquium f{\"u}r Instandhaltung, Diagnose und Anlagen{\"u}berwachung (AKIDA) am 15. und 16.11.2016, Technologiezentrum Aachen}, pages = {21 Folien}, year = {2016}, abstract = {In Deutschland liegt der Anteil der Windkraft an der Gesamtstromerzeugung bei 13,3\% mit mehr als 25.000 installierten Windenergieanlagen (WEA). Weltweit erf{\"a}hrt die Windbranche ein rasantes Wachstum. Indien und China berichten eine j{\"a}hrliche Wachstumsrate an Neuinstallationen von 45\%. Die Technologie zur Erzeugung elektrischer Energie aus Windkraft ist noch vergleichsweise jung. Durch die weltweit steigende Anzahl an Windenergieanlagen w{\"a}chst zunehmend der Bedarf an innovativen Wartungsl{\"o}sungen. Komponenten wie Generator oder Getriebe sind inzwischen weitestgehend ausgereift. Der Fokus richtet sich zunehmend auf die wesentliche Kernkomponente - die Rotorbl{\"a}tter. Industriekletterer inspizieren die Rotorbl{\"a}tter oder T{\"u}rme i.d.R. in einem zwei Jahres Rhythmus. Sie werden zunehmend durch Seilarbeitsb{\"u}hnen unterst{\"u}tzt. F{\"u}r gr{\"o}ßere Reparaturen kommen Kr{\"a}ne zum Einsatz, mit denen das Rotorblatt f{\"u}r die Instandhaltung demontiert wird. Die Standardinspektion besteht aus Sicht- und Klopfpr{\"u}fung der Rotorblattoberfl{\"a}che und ist nur bei sehr ruhiger Wetterlage durchf{\"u}hrbar. Seit September 2014 wird das Forschungsprojekt SMART (Scanning, Monitoring, Analysis, Repair and Transportation), Entwicklung einer Wartungsplattform f{\"u}r WEA, vom BMWi gef{\"o}rdert. Das Konsortium besteht aus zwei Firmen und der Fachhochschule Aachen. Die SMART-Anlage klettert reibschl{\"u}ssig am Turm der WEA mittels speziellen Kettenfahrwerken (Abbildung) auf- und abw{\"a}rts. Ein ringf{\"o}rmiges Spannsystems, basierend auf dem Konzept der „N{\"u}rnberger"-Schere, erzeugt die erforderliche Anpresskraft f{\"u}r den Kletterprozess. Wettergesch{\"u}tzte Arbeitskabinen erm{\"o}glichen die ganzj{\"a}hrige Instandhaltung von Rotorbl{\"a}ttern und ebenso T{\"u}rmen. Dadurch k{\"o}nnen Wartungsarbeiten auf 24 Stunden am Tag ausgeweitet werden. Der kombinierte Einsatz (Sensorfusion) bildgebender Messtechnik wie Thermografie, Ultraschall, und Terahertz in der Arbeitskabine kann die Dokumentation, Effizienz und Qualit{\"a}t der Instandhaltungsarbeiten erheblich verbessern. Langfristiges Ziel von SMART ist ein Condition Monitoring f{\"u}r Rotorbl{\"a}tter und T{\"u}rme auf Basis digitalisierter dreidimensionaler Volumenscans. Der kooperative Einsatz mit UAVs erweitert die Instandhaltungsstrategie. UAVs erm{\"o}glichen die schnelle, kosteng{\"u}nstige globale optische Inspektion von Rotorblattoberfl{\"a}chen zur Detektion potentieller Fehlstellen. Der „Proof-of-Concept" Meilenstein wurde mit der Demonstration eines funktionsf{\"a}higen Modells im Dezember 2015 erfolgreich abgeschlossen.}, language = {de} } @incollection{ScheerChuSalphatietal.2016, author = {Scheer, Nico and Chu, Xiaoyan and Salphati, Laurent and Zamek-Gliszczynski, Maciej J.}, title = {Knockout and humanized animal models to study membrane transporters in drug development}, series = {Drug Transporters: Volume 1: Role and Importance in ADME and Drug Development}, booktitle = {Drug Transporters: Volume 1: Role and Importance in ADME and Drug Development}, editor = {Nicholls, Glynis}, publisher = {Royal Society of Chemistry}, address = {Cambridge}, isbn = {978-1-78262-379-3}, doi = {10.1039/9781782623793-00298}, pages = {298 -- 332}, year = {2016}, language = {en} } @article{BillerbeckBarnatKnutzen2016, author = {Billerbeck, Katrin and Barnat, Miriam and Knutzen, S{\"o}nke}, title = {Kompetenzorientierung auf dem Pr{\"u}fstand. Erprobung von Indikatoren f{\"u}r den Kulturwandel}, series = {Die Hochschullehre}, volume = {2016}, journal = {Die Hochschullehre}, number = {16}, publisher = {WBV Media}, address = {Bielefeld}, issn = {2199-8825}, doi = {10.3278/HSL1616W}, pages = {16}, year = {2016}, abstract = {Der Beitrag fokussiert die Frage nach dem Stand des durch die Bologna-Reform angestoßenen Kulturwandels im Hinblick auf Kompetenzorientierung am Beispiel der Technischen Universit{\"a}t Hamburg (TUHH). An der TUHH wird bereits seit einigen Jahren daran gearbeitet, die Lehre grundlegend neu auszurichten. Hierf{\"u}r setzt das hochschuldidaktische "Zentrum f{\"u}r Lehre und Lernen" (ZLL) verschiedene Maßnahmen ein, wie z.B. eine finanzielle und didaktische Unterst{\"u}tzung von Lehrenden bei der Umstellung ihrer Veranstaltungen, Weiterqualifizierungsangebote und Informationsmaterial. Die Maßnahmen ebenso wie die innovierten Veranstaltungen werden von Lehrenden und Studierenden gut evaluiert. Nach dem Ansatz des Constructive Alignments l{\"a}sst sich jedoch davon ausgehen, dass der Bereich der Pr{\"u}fungen f{\"u}r eine Einsch{\"a}tzung des Status Quo der Kompetenzorientierung besonders relevant ist. Dieser wird deshalb anhand der beiden Kriterien Pr{\"u}fungsformate und Schwierigkeitsstufen von Pr{\"u}fungsaufgaben n{\"a}her beleuchtet, die eng mit der Kompetenzorientierung zusammen h{\"a}ngen. Ergebnisse hierzu aus einer universit{\"a}tsweiten Datenbank zur Studienorganisation sowie aus einer Online-Umfrage unter Studierenden weisen darauf hin, dass das Pr{\"u}fungsformat "Klausur" nach wie vor am st{\"a}rksten verbreitet ist; zugleich sind die Studierenden nach einer Selbsteinsch{\"a}tzung in Pr{\"u}fungen vorrangig mit Aufgaben auf den Taxonomieniveaus "Wiedergeben" und "Anwenden" konfrontiert. Dies l{\"a}sst sich als Hinweis darauf interpretieren, dass es im Hinblick auf eine Kompetenzorientierung in den Pr{\"u}fungen noch weiteren Ver{\"a}nderungsbedarf gibt.}, language = {de} } @inproceedings{PoghossianBronderSchejaetal.2016, author = {Poghossian, Arshak and Bronder, Thomas and Scheja, S. and Wu, Chunsheng and Metzger-Boddien, C. and Keusgen, M. and Sch{\"o}ning, Michael Josef}, title = {Label-free Electrostatic Detection of DNA Amplification by PCR Using Capacitive Field-effect Devices}, series = {Procedia Engineering}, volume = {Vol. 168}, booktitle = {Procedia Engineering}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1877-7058}, doi = {10.1016/j.proeng.2016.11.512}, pages = {514 -- 517}, year = {2016}, abstract = {A capacitive field-effect EIS (electrolyte-insulator-semiconductor) sensor modified with a positively charged weak polyelectrolyte of poly(allylamine hydrochloride) (PAH)/single-stranded probe DNA (ssDNA) bilayer has been used for a label-free electrostatic detection of pathogen-specific DNA amplification via polymerase chain reaction (PCR). The sensor is able to distinguish between positive and negative PCR solutions, to detect the existence of target DNA amplicons in PCR samples and thus, can be used as tool for a quick verification of DNA amplification and the successful PCR process.}, language = {en} } @article{VergePoettgenAltherretal.2016, author = {Verg{\´e}, Angela and P{\"o}ttgen, Philipp and Altherr, Lena and Ederer, Thorsten and Pelz, Peter F.}, title = {Lebensdauer als Optimierungsziel: Algorithmische Struktursynthese am Beispiel eines hydrostatischen Getriebes}, series = {O+P - {\"O}lhydraulik und Pneumatik}, volume = {60}, journal = {O+P - {\"O}lhydraulik und Pneumatik}, number = {1-2}, editor = {Greuloch, Ivo and Weber, Manfred and Meier, Miles}, publisher = {Vereinigte Fachverl.}, address = {Mainz}, issn = {1614-9602}, pages = {114 -- 121}, year = {2016}, abstract = {Verf{\"u}gbarkeit und Nachhaltigkeit sind wichtige Anforderungen bei der Planung langlebiger technischer Systeme. Meist werden bei Lebensdaueroptimierungen lediglich einzelne Komponenten vordefinierter Systeme untersucht. Ob eine optimale Lebensdauer eine g{\"a}nzlich andere Systemvariante bedingt, wird nur selten hinterfragt. Technical Operations Research (TOR) erlaubt es, aus Obermengen technischer Systeme automatisiert die lebensdaueroptimale Systemstruktur auszuw{\"a}hlen. Der Artikel zeigt dies am Beispiel eines hydrostatischen Getriebes.}, language = {de} } @incollection{Schloesser2016, author = {Schl{\"o}sser, Karl Helmut}, title = {Leistungsbeschreibung und Bauvertrag}, series = {Zahlentafeln f{\"u}r den Baubetrieb}, booktitle = {Zahlentafeln f{\"u}r den Baubetrieb}, edition = {9., {\"u}berarb. und aktual. Aufl.}, publisher = {Springer Vieweg}, address = {Wiesbaden}, isbn = {978-3-658-02838-1 (Online)}, doi = {10.1007/978-3-658-02838-1_6}, pages = {635 -- 961}, year = {2016}, abstract = {Das Gesetz gegen Wettbewerbsbeschr{\"a}nkungen bildet die Grundlage f{\"u}r die Verordnung {\"u}ber die Vergabe {\"o}ffentlicher Auftr{\"a}ge, aus der sich die Vergabe- und Vertragsordnungen f{\"u}r Freiberufliche Leistungen (VOF), f{\"u}r Lieferungen und Leistungen (VOL) und f{\"u}r Bauleistungen (VOB) ableiten. Die dabei in Frage kommenden Vergabeverfahren und die einzelnen Schwellenwerte gem{\"a}ß EU-Recht werden detailliert aufbereitet und im Zusammenhang dargestellt. Die f{\"u}r die Ausgestaltung von Bauvertr{\"a}gen notwendigen Grundlagen des Werkvertragsrecht nach BGB sowie die branchenspezifischen Allgemeinen Gesch{\"a}ftsbedingungen in Form der Vertragsordnung f{\"u}r Bauleistungen (VOB) mit ihren Zus{\"a}tzlichen und Besonderen Vertragsbedingungen werden intensiv aufbereitet. Das Zustandekommen eines Bauvertrages ergibt sich dann aus der notwendigen Leistungsbeschreibung mit einem Leistungsverzeichnis und verschiedenen Positionen oder in Form einer Funktionalen Leistungsbeschreibung (Beschreibung mit Leistungsprogramm). Das Auslandsgesch{\"a}ft der Baubranche (Bauausf{\"u}hrende Unternehmen sowie Beratende Ingenieure und Consultants) wird von den jeweils vorliegenden Internationalen Wettbewerbsbedingungen bestimmt, deren Zusammenh{\"a}nge anhand umfangreicher statistischer Daten und anhand von Beispielen dargestellt werden.}, language = {de} } @article{WagnerVornholtWerneretal.2016, author = {Wagner, Torsten and Vornholt, Wolfgang and Werner, Frederik and Yoshinobu, Tatsuo and Miyamoto, Ko-Ichiro and Keusgen, Michael and Sch{\"o}ning, Michael Josef}, title = {Light-addressable potentiometric sensor (LAPS) combined with magnetic beads for pharmaceutical screening}, series = {Physics in medicine}, volume = {2016}, journal = {Physics in medicine}, number = {1}, issn = {2352-4510}, doi = {10.1016/j.phmed.2016.03.001}, pages = {2 -- 7}, year = {2016}, abstract = {The light-addressable potentiometric sensor (LAPS) has the unique feature to address different regions of a sensor surface without the need of complex structures. Measurements at different locations on the sensor surface can be performed in a common analyte solution, which distinctly simplifies the fluidic set-up. However, the measurement in a single analyte chamber prevents the application of different drugs or different concentrations of a drug to each measurement spot at the same time as in the case of multi-reservoir-based set-ups. In this work, the authors designed a LAPS-based set-up for cell culture screening that utilises magnetic beads loaded with the endotoxin (lipopolysaccharides, LPS), to generate a spatially distributed gradient of analyte concentration. Different external magnetic fields can be adjusted to move the magnetic beads loaded with a specific drug within the measurement cell. By recording the metabolic activities of a cell layer cultured on top of the LAPS surface, this work shows the possibility to apply different concentrations of a sample along the LAPS measurement spots within a common analyte solution.}, language = {en} } @article{MiyamotoSatoAbeetal.2016, author = {Miyamoto, Ko-Ichiro and Sato, Takuya and Abe, Minami and Wagner, Torsten and Sch{\"o}ning, Michael Josef and Yoshinobu, Tatsuo}, title = {Light-addressable potentiometric sensor as a sensing element in plug-based microfluidic devices}, series = {Micromachines}, volume = {7}, journal = {Micromachines}, number = {7}, publisher = {MDPI}, address = {Basel}, issn = {2072-666X}, doi = {10.3390/mi7070111}, pages = {111}, year = {2016}, abstract = {A plug-based microfluidic system based on the principle of the light-addressable potentiometric sensor (LAPS) is proposed. The LAPS is a semiconductor-based chemical sensor, which has a free addressability of the measurement point on the sensing surface. By combining a microfluidic device and LAPS, ion sensing can be performed anywhere inside the microfluidic channel. In this study, the sample solution to be measured was introduced into the channel in a form of a plug with a volume in the range of microliters. Taking advantage of the light-addressability, the position of the plug could be monitored and pneumatically controlled. With the developed system, the pH value of a plug with a volume down to 400 nL could be measured. As an example of plug-based operation, two plugs were merged in the channel, and the pH change was detected by differential measurement.}, language = {en} } @inproceedings{EngelThieringerTippkoetter2016, author = {Engel, Mareike and Thieringer, Julia and Tippk{\"o}tter, Nils}, title = {Linking bioprocess engineering and electrochemistry for sustainable biofuel production}, series = {Young Researchers Symposium, YRS 2016. Proceedings}, booktitle = {Young Researchers Symposium, YRS 2016. Proceedings}, publisher = {Fraunhofer Verlag}, address = {Karlsruhe}, pages = {49 -- 53}, year = {2016}, abstract = {Electromicrobial engineering is an emerging, highly interdisciplinary research area linking bioprocesses with electrochemistry. In this work, microbial electrosynthesis (MES) of biobutanol is carried out during acetone-butanol-ethanol (ABE) fermentations with Clostridium acetobutylicum. A constant electric potential of -600mV (vs. Ag/AgCl) with simultaneous addition of the soluble redox mediator neutral red is used in order to study the electron transfer between the working electrode and the bacterial cells. The results show an earlier initiation of solvent production for all fermentations with applied potential compared to the conventional ABE fermentation. The f inal butanol concentration can be more than doubled by the application of a negative potential combined with addition of neutral red. Moreover a higher biofilm formation on the working electrode compared to control cultivations has been observed. In contrast to previous studies, our results also indicate that direct electron transfer (DET) might be possible with C. acetobutylicum. The presented results make microbial butanol production economically attractive and therefore support the development of sustainable production processes in the chemical industry aspired by the "Centre for resource-efficient chemistry and raw material change" as well as the the project "NanoKat" working on nanostructured catalysts in Kaiserslautern.}, language = {en} } @article{FerreinSteinbauer2016, author = {Ferrein, Alexander and Steinbauer, Gerald}, title = {Looking back on 20 Years of RoboCup}, series = {KI - K{\"u}nstliche Intelligenz}, volume = {30}, journal = {KI - K{\"u}nstliche Intelligenz}, number = {3-4}, publisher = {Springer}, address = {Berlin}, issn = {1610-1987}, doi = {10.1007/s13218-016-0443-y}, pages = {321 -- 323}, year = {2016}, language = {en} } @article{ButenwegMarinkovicKubalskietal.2016, author = {Butenweg, Christoph and Marinkovic, Marko and Kubalski, Thomas and Klinkel, Sven}, title = {Masonry infilled reinforced concrete frames under horizontal loading}, series = {Mauerwerk}, volume = {20}, journal = {Mauerwerk}, number = {4}, publisher = {Ernst \& Sohn}, address = {Berlin}, issn = {1437-1022}, doi = {10.1002/dama.201600703}, pages = {305 -- 312}, year = {2016}, abstract = {The behaviour of infilled reinforced concrete frames under horizontal load has been widely investigated, both experimentally and numerically. Since experimental tests represent large investments, numerical simulations offer an efficient approach for a more comprehensive analysis. When RC frames with masonry infill walls are subjected to horizontal loading, their behaviour is highly non-linear after a certain limit, which makes their analysis quite difficult. The non-linear behaviour results from the complex inelastic material properties of the concrete, infill wall and conditions at the wall-frame interface. In order to investigate this non-linear behaviour in detail, a finite element model using a micro modelling approach is developed, which is able to predict the complex non-linear behaviour resulting from the different materials and their interaction. Concrete and bricks are represented by a non-linear material model, while each reinforcement bar is represented as an individual part installed in the concrete part and behaving elasto-plastically. Each brick is modelled individually and connected taking into account the non-linearity of a brick mortar interface. The same approach is followed using two finite element software packages and the results are compared with the experimental results. The numerical models show a good agreement with the experiments in predicting the overall behaviour, but also very good matching for strength capacity and drift. The results emphasize the quality and the valuable contribution of the numerical models for use in parametric studies, which are needed for the derivation of design recommendations for infilled frame structures.}, language = {en} } @article{GossmannFrotscherLinderetal.2016, author = {Goßmann, Matthias and Frotscher, Ralf and Linder, Peter and Bayer, Robin and Epple, U. and Staat, Manfred and Temiz Artmann, Ayseg{\"u}l and Artmann, Gerhard}, title = {Mechano-pharmacological characterization of cardiomyocytes derived from human induced pluripotent stem cells}, series = {Cellular physiology and biochemistry}, volume = {38}, journal = {Cellular physiology and biochemistry}, number = {3}, publisher = {Karger}, address = {Basel}, issn = {1421-9778 (Online)}, doi = {10.1159/000443124}, pages = {1182 -- 1198}, year = {2016}, abstract = {Background/Aims: Common systems for the quantification of cellular contraction rely on animal-based models, complex experimental setups or indirect approaches. The herein presented CellDrum technology for testing mechanical tension of cellular monolayers and thin tissue constructs has the potential to scale-up mechanical testing towards medium-throughput analyses. Using hiPS-Cardiac Myocytes (hiPS-CMs) it represents a new perspective of drug testing and brings us closer to personalized drug medication. Methods: In the present study, monolayers of self-beating hiPS-CMs were grown on ultra-thin circular silicone membranes and deflect under the weight of the culture medium. Rhythmic contractions of the hiPS-CMs induced variations of the membrane deflection. The recorded contraction-relaxation-cycles were analyzed with respect to their amplitudes, durations, time integrals and frequencies. Besides unstimulated force and tensile stress, we investigated the effects of agonists and antagonists acting on Ca²⁺ channels (S-Bay K8644/verapamil) and Na⁺ channels (veratridine/lidocaine). Results: The measured data and simulations for pharmacologically unstimulated contraction resembled findings in native human heart tissue, while the pharmacological dose-response curves were highly accurate and consistent with reference data. Conclusion: We conclude that the combination of the CellDrum with hiPS-CMs offers a fast, facile and precise system for pharmacological, toxicological studies and offers new preclinical basic research potential.}, language = {en} } @article{HarishWriggersJungketal.2016, author = {Harish, Ajay B. and Wriggers, Peter and Jungk, Juliane and Hojdis, Nils and Recker, Carla}, title = {Mesoscale Constitutive Modeling of Non-Crystallizing Filled Elastomers}, series = {Computational Mechanics}, volume = {57}, journal = {Computational Mechanics}, publisher = {Springer}, address = {Berlin}, issn = {1432-0924}, doi = {10.1007/s00466-015-1251-1}, pages = {653 -- 677}, year = {2016}, abstract = {Elastomers are exceptional materials owing to their ability to undergo large deformations before failure. However, due to their very low stiffness, they are not always suitable for industrial applications. Addition of filler particles provides reinforcing effects and thus enhances the material properties that render them more versatile for applications like tyres etc. However, deformation behavior of filled polymers is accompanied by several nonlinear effects like Mullins and Payne effect. To this day, the physical and chemical changes resulting in such nonlinear effect remain an active area of research. In this work, we develop a heterogeneous (or multiphase) constitutive model at the mesoscale explicitly considering filler particle aggregates, elastomeric matrix and their mechanical interaction through an approximate interface layer. The developed constitutive model is used to demonstrate cluster breakage, also, as one of the possible sources for Mullins effect observed in non-crystallizing filled elastomers.}, language = {en} } @inproceedings{EngelThieringerTippkoetter2016, author = {Engel, M. and Thieringer, J. and Tippk{\"o}tter, Nils}, title = {Microbial electrosynthesis for sustainable biobutanol production}, series = {New frontiers of biotech-processes (Himmelfahrtstagung) : 02-04 May 2016, Rhein-Mosel-Halle, Koblenz/Germany}, booktitle = {New frontiers of biotech-processes (Himmelfahrtstagung) : 02-04 May 2016, Rhein-Mosel-Halle, Koblenz/Germany}, publisher = {DECHEMA}, address = {Frankfurt am Main}, pages = {77 -- 78}, year = {2016}, language = {en} }