@article{ZhangHeimbachScheeretal.2016,
  author    = {Zhang, Jin and Heimbach, Tycho and Scheer, Nico and Barve, Avantika and Li, Wenkui and Lin, Wen and He, Handan},
  title     = {Clinical Exposure Boost Predictions by Integrating Cytochrome P450 3A4-Humanized Mouse Studies With PBPK Modeling},
  series = {Journal of Pharmaceutical Sciences},
  volume    = {Volume 105},
  journal   = {Journal of Pharmaceutical Sciences},
  number    = {Issue 4},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0022-3549},
  doi       = {doi.org/10.1016/j.xphs.2016.01.021},
  pages     = {1398 -- 1404},
  year      = {2016},
  abstract  = {NVS123 is a poorly water-soluble protease 56 inhibitor in clinical development. Data from in vitro hepatocyte studies suggested that NVS123 is mainly metabolized by CYP3A4. As a consequence of limited solubility, NVS123 therapeutic plasma exposures could not be achieved even with high doses and optimized formulations. One approach to overcome NVS123 developability issues was to increase plasma exposure by coadministrating it with an inhibitor of CYP3A4 such as ritonavir. A clinical boost effect was predicted by using physiologically based pharmacokinetic (PBPK) modeling. However, initial boost predictions lacked sufficient confidence because a key parameter, fraction of drug metabolized by CYP3A4 (ƒₘCYP3A4), could not be estimated with accuracy on account of disconnects between in vitro and in vivo preclinical data. To accurately estimate ƒₘCYP3A4 in human, an in vivo boost effect study was conducted using CYP3A4-humanized mouse model which showed a 33- to 56-fold exposure boost effect. Using a top-down approach, human ƒₘCYP3A4 for NVS123 was estimated to be very high and included in the human PBPK modeling to support subsequent clinical study design. The combined use of the in vivo boost study in CYP3A4-humanized mouse model mice along with PBPK modeling accurately predicted the clinical outcome and identified a significant NVS123 exposure boost (∼42-fold increase) with ritonavir.},
  language  = {en}
}
@article{WulfhorstDuweMerseburgetal.2016,
  author    = {Wulfhorst, Helene and Duwe, Anna-Maria and Merseburg, Johannes and Tippk{\"o}tter, Nils},
  title     = {Compositional analysis of pretreated (beech) wood using differential scanning calorimetry and multivariate data analysis},
  series = {Tetrahedron},
  volume    = {72},
  journal   = {Tetrahedron},
  number    = {46},
  publisher = {Elsevier},
  address   = {Amsterdam},
  doi       = {10.1016/j.tet.2016.04.029},
  pages     = {7329 -- 7334},
  year      = {2016},
  abstract  = {The composition of plant biomass varies depending on the feedstock and pre-treatment conditions and influences its processing in biorefineries. In order to ensure optimal process conditions, the quantitative proportion of the main polymeric components of the pre-treated biomass has to be determined. Current standard procedures for biomass compositional analysis are complex, the measurements are afflicted with errors and therefore often not comparable. Hence, new powerful analytical methods are urgently required to characterize biomass. In this contribution, Differential Scanning Calorimetry (DSC) was applied in combination with multivariate data analysis (MVA) to detect the cellulose content of the plant biomass pretreated by Liquid Hot Water (LHW) and Organosolv processes under various conditions. Unlike conventional techniques, the developed analytic method enables the accurate quantification of monosaccharide content of the plant biomass without any previous sample preparation. It is easy to handle and avoids errors in sample preparation.},
  language  = {en}
}
@inproceedings{WulfhorstDuweMoehringetal.2016,
  author    = {Wulfhorst, H. and Duwe, A. and M{\"o}hring, S. and Jurca, O. and Tippk{\"o}tter, Nils},
  title     = {Analysis of pretreated biomass by differential scanning 132 calorimetry and multivariate data analysis},
  series = {New frontiers of biotech-processes (Himmelfahrtstagung) : 02-04 May 2016, Rhein-Mosel-Halle, Koblenz/Germany},
  booktitle = {New frontiers of biotech-processes (Himmelfahrtstagung) : 02-04 May 2016, Rhein-Mosel-Halle, Koblenz/Germany},
  publisher = {DECHEMA},
  address   = {Frankfurt am Main},
  pages     = {132},
  year      = {2016},
  language  = {en}
}
@inproceedings{WuKemper2016,
  author    = {Wu, Ziyi and Kemper, Hans},
  title     = {The optimal 48 V - battery pack for a specific load profile of a heavy duty vehicle},
  series = {8. Internationale Fachtagung Kraftwerk Batterie : 26. - 27. April 2016, M{\"u}nster, Deutschland},
  booktitle = {8. Internationale Fachtagung Kraftwerk Batterie : 26. - 27. April 2016, M{\"u}nster, Deutschland},
  year      = {2016},
  language  = {en}
}
@article{WuPoghossianBronderetal.2016,
  author    = {Wu, Chunsheng and Poghossian, Arshak and Bronder, Thomas and Sch{\"o}ning, Michael Josef},
  title     = {Sensing of double-stranded DNA molecules by their intrinsic molecular charge using the light-addressable potentiometric sensor},
  series = {Sensors and Actuators B: Chemical},
  journal   = {Sensors and Actuators B: Chemical},
  number    = {229},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0925-4005},
  doi       = {10.1016/j.snb.2016.02.004},
  pages     = {506 -- 512},
  year      = {2016},
  abstract  = {A multi-spot light-addressable potentiometric sensor (LAPS), which belongs to the family of semiconductor field-effect devices, was applied for label-free detection of double-stranded deoxyribonucleic acid (dsDNA) molecules by their intrinsic molecular charge. To reduce the distance between the DNA charge and sensor surface and thus, to enhance the electrostatic coupling between the dsDNA molecules and the LAPS, the negatively charged dsDNA molecules were electrostatically adsorbed onto the gate surface of the LAPS covered with a positively charged weak polyelectrolyte layer of PAH (poly(allylamine hydrochloride)). The surface potential changes in each spot of the LAPS, induced by the layer-by-layer adsorption of a PAH/dsDNA bilayer, were recorded by means of photocurrent-voltage and constant-photocurrent measurements. In addition, the surface morphology of the gate surface before and after consecutive electrostatic adsorption of PAH and dsDNA layers was studied by atomic force microscopy measurements. Moreover, fluorescence microscopy was used to verify the successful adsorption of dsDNA molecules onto the PAH-modified LAPS surface. A high sensor signal of 25 mV was registered after adsorption of 10 nM dsDNA molecules. The lower detection limit is down to 0.1 nM dsDNA. The obtained results demonstrate that the PAH-modified LAPS device provides a convenient and rapid platform for the direct label-free electrical detection of in-solution hybridized dsDNA molecules.},
  language  = {en}
}
@article{Wrede2016,
  author    = {Wrede, Oliver},
  title     = {Continuity in travel information},
  series = {Information Design Journal},
  volume    = {22},
  journal   = {Information Design Journal},
  number    = {2},
  publisher = {John Benjamins},
  address   = {Amsterdam},
  issn      = {0142-5471},
  doi       = {10.1075/idj.22.2.09wre},
  pages     = {172 -- 178},
  year      = {2016},
  abstract  = {This article discusses the contrast between the information transportation companies provide to travellers and that of their brand messaging. Companies' brand messaging often portrays the service they provide as pleasant, stress free and perfect. Customers and users of the service, on the other hand, often describe their experience of the service as a negative one. This article suggests that the brand value would be greater if transportation companies paid more attention to the users' experience when designing their information systems, particularly in worst case scenarios.},
  language  = {en}
}
@article{WollertBooke2016,
  author    = {Wollert, J{\"o}rg and Booke, Andreas},
  title     = {IoT von der Stange},
  series = {elektronik},
  journal   = {elektronik},
  number    = {21 (2016)},
  publisher = {WEKA-Fachmedien},
  address   = {M{\"u}nchen},
  pages     = {30 -- 37},
  year      = {2016},
  abstract  = {Heute sollte am besten jedes Ger{\"a}t in die große Rechnerwolke eingebettet werden. Doch so einfach ist das nicht, denn Cloud ist viel mehr als nur das Internet der Dinge. Als Anwender muss man sich also fragen, welche Dienste man m{\"o}chte und welchem Anbieter man sein Vertrauen schenkt.},
  language  = {de}
}
@inproceedings{Wollert2016,
  author    = {Wollert, J{\"o}rg},
  title     = {Industrie 4.0 - warten bis die Revolution vorbei ist?},
  series = {Automatisierung im Fokus von Industrie 4.0 : Tagungsband AALE 2016 ; 13. Fachkonferenz, L{\"u}beck},
  booktitle = {Automatisierung im Fokus von Industrie 4.0 : Tagungsband AALE 2016 ; 13. Fachkonferenz, L{\"u}beck},
  publisher = {DIV Deutscher Industrieverlag GmbH},
  address   = {M{\"u}nchen},
  isbn      = {978-3-8356-7312-0},
  pages     = {127 -- 136},
  year      = {2016},
  language  = {de}
}
@article{Wollert2016,
  author    = {Wollert, J{\"o}rg},
  title     = {Rapid Application Development},
  series = {Design \& Elektronik},
  journal   = {Design \& Elektronik},
  number    = {4},
  publisher = {WEKA-Fachmedien},
  address   = {M{\"u}nchen},
  issn      = {0933-8667},
  pages     = {8 -- 11},
  year      = {2016},
  abstract  = {Das IoT ist ohne eingebettete Systeme undenkbar. Erst kleine und kleinste Mikrocontroller mit intelligenten Kommunikationsschnittstellen und Anbindung ans Internet erm{\"o}glichen sinnvolles und fl{\"a}chendeckendes Einsammeln von Daten. Doch wie kompliziert ist der Einstieg in die Embedded-Welt? Dieser Artikel gibt Einblick, wie die »Arduino-Plattform« die Einstiegsh{\"u}rden f{\"u}r eingebettete Systeme dramatisch reduzieren kann.},
  language  = {de}
}
@article{Wollert2016,
  author    = {Wollert, J{\"o}rg},
  title     = {Industrial Internet of Things : Seifenblase oder Revolution},
  series = {Elektronik},
  journal   = {Elektronik},
  number    = {7},
  publisher = {WEKA-Fachmedien},
  address   = {M{\"u}nchen},
  issn      = {0013-5658},
  pages     = {39 -- 45},
  year      = {2016},
  language  = {de}
}
@article{Wollert2016,
  author    = {Wollert, J{\"o}rg},
  title     = {OS-Funktionalit{\"a}t ohne OS f{\"u}r das IoT},
  series = {Design \& Elektronik},
  journal   = {Design \& Elektronik},
  number    = {11},
  publisher = {WEKA-Fachmedien},
  address   = {M{\"u}nchen},
  issn      = {0933-8667},
  pages     = {85 -- 90},
  year      = {2016},
  abstract  = {Low-end-Embedded-Plattformen stellen eine hohe Anforderung an die Entscheidungsf{\"a}higkeit des Entwicklers: Zum n{\"a}chstgr{\"o}ßeren Prozessor greifen und ein Betriebssystem benutzen oder doch besser auf das Betriebssystem verzichten? Die Frage l{\"a}sst sich einfach beantworten: Einen Nanokernel verwenden und das Embedded-System mit einem minimalen Footprint realisieren. Adam Dunkels Protothreads sind eine ausgesprochen effiziente Art, Mikrocontroller gut strukturiert zu programmieren und gleichzeitig auf Overhead zu verzichten. So k{\"o}nnen auch mit kleinen 8-bit-Prozessoren anspruchsvolle Aufgaben in einem Thread-Modell bearbeitet werden. Man muss also nicht immer das Rad neu erfinden oder gleich auf Linux-basierte Systeme zur{\"u}ckgreifen.},
  language  = {de}
}
@incollection{Winkler2016,
  author    = {Winkler, Norbert},
  title     = {Vermessung},
  series = {Zahlentafeln f{\"u}r den Baubetrieb},
  booktitle = {Zahlentafeln f{\"u}r den Baubetrieb},
  edition   = {9., {\"u}berarb. und aktual. Aufl.},
  publisher = {Springer Vieweg},
  address   = {Wiesbaden},
  isbn      = {978-3-658-02838-1 (Online)},
  doi       = {10.1007/978-3-658-02838-1_3},
  pages     = {159 -- 177},
  year      = {2016},
  language  = {de}
}
@book{Wilke2016,
  author    = {Wilke, Thomas},
  title     = {Innendekoration : graphische Vorlagen und theoretische Vorgaben f{\"u}r die wandfeste Dekoration von Appartement im 17. und 18. Jahrhundert in Frankreich},
  publisher = {scaneg Verlag},
  address   = {M{\"u}nchen},
  isbn      = {978-3-89235-233-4},
  pages     = {2 B{\"a}nde},
  year      = {2016},
  language  = {de}
}
@incollection{Wilke2016,
  author    = {Wilke, Thomas},
  title     = {Planning Process of the Di Castellamonte's Chapel of the Holy Shroud},
  series = {Carlo e Amedeo di Castellamonte : 1571-1683, ingegneri e architetti per i duchi di Savoia},
  booktitle = {Carlo e Amedeo di Castellamonte : 1571-1683, ingegneri e architetti per i duchi di Savoia},
  editor    = {Merlotti, Andrea},
  publisher = {Campisano editore},
  address   = {Rom},
  isbn      = {978-88-98229-57-4},
  pages     = {141 -- 152},
  year      = {2016},
  language  = {en}
}
@techreport{WeisSchornAnthrakidisetal.2016,
  author    = {Weis, Fabian and Schorn, Christian and Anthrakidis, Anette and Herrmann, Ulf},
  title     = {Entwicklung eines kleinen Parabolrinnenkollektors mit Kunststoffkorpus zur Bereitstellung solarer Prozessw{\"a}rme : Poly-P : Abschlussbericht},
  publisher = {Solar-Institut J{\"u}lich},
  address   = {J{\"u}lich},
  pages     = {56 Seiten},
  year      = {2016},
  language  = {de}
}
@article{WegmannHacklStaatetal.2016,
  author    = {Wegmann, Kilian and Hackl, Michael and Staat, Manfred and Mayer, Katharina and M{\"u}ller, Lars-Peter},
  title     = {Double plate osteosynthesis of proximal ulna fractures: biomechanical and clinical results},
  series = {Knee surgery, sports traumatology, arthroscopy},
  volume    = {Volume 24},
  journal   = {Knee surgery, sports traumatology, arthroscopy},
  number    = {Supplement 1},
  publisher = {Springer},
  address   = {Berlin},
  issn      = {0942-2056},
  doi       = {10.1007/s00167-016-4079-0},
  pages     = {58 -- 59},
  year      = {2016},
  abstract  = {While plate fixation of proximal ulna fractures might lead to superior clinical results compared to tension band wiring, regular plates represent an established risk factor for wound complications. The olecranon double plates (Medartis, Basel, CH) might decrease complications related to the osteosynthesis because of their low profile and better anatomical fit. This study aimed to evaluate the biomechanical performance and clinical results of the olecranon double plates.},
  language  = {en}
}
@inproceedings{WeberTellisDuhovic2016,
  author    = {Weber, Tobias and Tellis, Jane J. and Duhovic, Miro},
  title     = {Characterization of tool-part-interaction an interlaminar friction for manufacturing process simulation},
  series = {ECCM 17, 17th European Conference on Composite Materials, M{\"u}nchen, DE, Jun 26-30, 2016},
  booktitle = {ECCM 17, 17th European Conference on Composite Materials, M{\"u}nchen, DE, Jun 26-30, 2016},
  isbn      = {978-3-00-053387-7},
  pages     = {1 -- 7},
  year      = {2016},
  language  = {en}
}
@article{WeberArentMuenchetal.2016,
  author    = {Weber, Tobias and Arent, Jan-Christoph and M{\"u}nch, Lukas and Duhovic, Miro and Balvers, Johannes M.},
  title     = {A fast method for the generation of boundary conditions for thermal autoclave simulation},
  series = {Composites Part A},
  volume    = {88},
  journal   = {Composites Part A},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1359-835X},
  doi       = {10.1016/j.compositesa.2016.05.036},
  pages     = {216 -- 225},
  year      = {2016},
  abstract  = {Manufacturing process simulation enables the evaluation and improvement of autoclave mold concepts early in the design phase. To achieve a high part quality at low cycle times, the thermal behavior of the autoclave mold can be investigated by means of simulations. Most challenging for such a simulation is the generation of necessary boundary conditions. Heat-up and temperature distribution in an autoclave mold are governed by flow phenomena, tooling material and shape, position within the autoclave, and the chosen autoclave cycle. This paper identifies and summarizes the most important factors influencing mold heat-up and how they can be introduced into a thermal simulation. Thermal measurements are used to quantify the impact of the various parameters. Finally, the gained knowledge is applied to develop a semi-empirical approach for boundary condition estimation that enables a simple and fast thermal simulation of the autoclave curing process with reasonably high accuracy for tooling optimization.},
  language  = {en}
}
@article{WagnerVornholtWerneretal.2016,
  author    = {Wagner, Torsten and Vornholt, Wolfgang and Werner, Frederik and Yoshinobu, Tatsuo and Miyamoto, Ko-Ichiro and Keusgen, Michael and Sch{\"o}ning, Michael Josef},
  title     = {Light-addressable potentiometric sensor (LAPS) combined with magnetic beads for pharmaceutical screening},
  series = {Physics in medicine},
  volume    = {2016},
  journal   = {Physics in medicine},
  number    = {1},
  issn      = {2352-4510},
  doi       = {10.1016/j.phmed.2016.03.001},
  pages     = {2 -- 7},
  year      = {2016},
  abstract  = {The light-addressable potentiometric sensor (LAPS) has the unique feature to address different regions of a sensor surface without the need of complex structures. Measurements at different locations on the sensor surface can be performed in a common analyte solution, which distinctly simplifies the fluidic set-up. However, the measurement in a single analyte chamber prevents the application of different drugs or different concentrations of a drug to each measurement spot at the same time as in the case of multi-reservoir-based set-ups. In this work, the authors designed a LAPS-based set-up for cell culture screening that utilises magnetic beads loaded with the endotoxin (lipopolysaccharides, LPS), to generate a spatially distributed gradient of analyte concentration. Different external magnetic fields can be adjusted to move the magnetic beads loaded with a specific drug within the measurement cell. By recording the metabolic activities of a cell layer cultured on top of the LAPS surface, this work shows the possibility to apply different concentrations of a sample along the LAPS measurement spots within a common analyte solution.},
  language  = {en}
}
@article{VergePoettgenAltherretal.2016,
  author    = {Verg{\´e}, Angela and P{\"o}ttgen, Philipp and Altherr, Lena and Ederer, Thorsten and Pelz, Peter F.},
  title     = {Lebensdauer als Optimierungsziel: Algorithmische Struktursynthese am Beispiel eines hydrostatischen Getriebes},
  series = {O+P - {\"O}lhydraulik und Pneumatik},
  volume    = {60},
  journal   = {O+P - {\"O}lhydraulik und Pneumatik},
  number    = {1-2},
  editor    = {Greuloch, Ivo and Weber, Manfred and Meier, Miles},
  publisher = {Vereinigte Fachverl.},
  address   = {Mainz},
  issn      = {1614-9602},
  pages     = {114 -- 121},
  year      = {2016},
  abstract  = {Verf{\"u}gbarkeit und Nachhaltigkeit sind wichtige Anforderungen bei der Planung langlebiger technischer Systeme. Meist werden bei Lebensdaueroptimierungen lediglich einzelne Komponenten vordefinierter Systeme untersucht. Ob eine optimale Lebensdauer eine g{\"a}nzlich andere Systemvariante bedingt, wird nur selten hinterfragt. Technical Operations Research (TOR) erlaubt es, aus Obermengen technischer Systeme automatisiert die lebensdaueroptimale Systemstruktur auszuw{\"a}hlen. Der Artikel zeigt dies am Beispiel eines hydrostatischen Getriebes.},
  language  = {de}
}