@article{RothTippkoetter2016,
  author    = {Roth, Jasmine and Tippk{\"o}tter, Nils},
  title     = {Evaluation of lignocellulosic material for butanol production using enzymatic hydrolysate medium},
  series = {Cellulose Chemistry and Technology},
  volume    = {50},
  journal   = {Cellulose Chemistry and Technology},
  number    = {3-4},
  publisher = {Editura Academiei Romane},
  address   = {Bukarest},
  pages     = {405 -- 410},
  year      = {2016},
  abstract  = {Butanol is a promising gasoline additive and platform chemical that can be readily produced via acetone-butanolethanol (ABE) fermentation from pretreated lignocellulosic materials. This article examines lignocellulosic material from beech wood for ABE fermentation, using Clostridium acetobutylicum. First, the utilization of both C₅₋ (xylose) and C₆₋ (glucose) sugars as sole carbon source was investigated in static cultivation, using serum bottles and synthetic medium. The utilization of pentose sugar resulted in a solvent yield of 0.231 g·g_sugar⁻¹, compared to 0.262 g·g_sugar⁻¹ using hexose. Then, the Organosolv pretreated crude cellulose fibers (CF) were enzymatically decomposed, and the resulting hydrolysate medium was analyzed for inhibiting compounds (furans, organic acids, phenolics) and treated with ionexchangers for detoxification. Batch fermentation in a bioreactor using CF hydrolysate medium resulted in a total solvent yield of 0.20 gABE·g_sugar⁻¹.},
  language  = {en}
}
@misc{RothTippkoetter2016,
  author    = {Roth, J. and Tippk{\"o}tter, Nils},
  title     = {New Approach for Enzymatic Hydrolysis of Lignocellulose with Selective Diffusion Separation of the Monosaccharide Products},
  series = {Chemie Ingenieur Technik},
  volume    = {88},
  journal   = {Chemie Ingenieur Technik},
  number    = {9},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {0009-286X},
  doi       = {10.1002/cite.201650301},
  pages     = {1237},
  year      = {2016},
  abstract  = {Enzymatic hydrolysis of lignocellulosic material plays an important role in the classical biorefinery approach. Apart from the pretreatment of the raw material, hydrolysis is the basis for the conversion of the cellulose and hemicellulose fraction into fermentable sugars. After hydrolysis, usually a solid-liquid separation takes place, in order to separate the residual plant material from the sugar-rich fraction, which can be subsequently used in a fermentation step. In order to factor out the separation step, the usage of in alginate immobilized crude cellulose fiber beads (CFBs) were evaluated. Pretreated cellulose fibers are incorporated in an alginate matrix together with the relevant enzymes. In doing so, sugars diffuse trough the alginate matrix, allowing a simplified delivery into the surrounding fluid. This again reduces product inhibition of the glucose on the enzyme catalysts. By means of standardized bead production the hydrolysis in lab scale was possible. First results show that liberation of glucose and xylose is possible, allowing a maximum total sugar yield of 75 \%.},
  language  = {en}
}
@inproceedings{RothMoehringTippkoetter2016,
  author    = {Roth, J. and M{\"o}hring, S. and Tippk{\"o}tter, Nils},
  title     = {Characterization and evaluation of lignocellulosic biomass 130 hydrolysates for ABE fermentation},
  series = {New frontiers of biotech-processes (Himmelfahrtstagung) : 02-04 May 2016, Rhein-Mosel-Halle, Koblenz/Germany},
  booktitle = {New frontiers of biotech-processes (Himmelfahrtstagung) : 02-04 May 2016, Rhein-Mosel-Halle, Koblenz/Germany},
  publisher = {DECHEMA},
  address   = {Frankfurt am Main},
  pages     = {130},
  year      = {2016},
  language  = {en}
}
@article{PinkenburgSchiffelsSelmer2016,
  author    = {Pinkenburg, Olaf and Schiffels, Johannes and Selmer, Thorsten},
  title     = {Das CoLibry-Konzept - ein Werkzeugkasten f{\"u}r die Synthetische Biologie: Bioproduktion},
  series = {BIOspektrum},
  volume    = {22},
  journal   = {BIOspektrum},
  number    = {6},
  publisher = {Springer},
  address   = {Berlin},
  doi       = {10.1007/s12268-016-0734-8},
  pages     = {593 -- 595},
  year      = {2016},
  abstract  = {Regardless of size or destination, synthetic biology starts with com-parably small information units, which need to be combined and properly arranged in order to achieve a certain goal. This may be the de novo synthesis of individual genes from oligonucleotides, a shuffling of protein domains in order to create novel biocatalysts, the assembly of multiple enzyme encoding genes in metabolic pathway design, or strain development at the production stage. The CoLibry concept has been designed in order to close the gap between recombinant production of individual genes and genome editing.},
  language  = {de}
}
@article{PaulssenLengkeekLeetal.2016,
  author    = {Paulßen, Elisabeth and Lengkeek, Nigel A. and Le, Van So and Pellegrini, Paul A. and Greguric, Ivan and Weiner, Ron},
  title     = {The role of additives in moderating the influence of Fe(III) and Cu(II) on the radiochemical yield of [⁶⁸Ga(DOTATATE)]},
  series = {Applied Radiation and Isotopes},
  volume    = {107},
  journal   = {Applied Radiation and Isotopes},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1872-9800},
  doi       = {10.1016/j.apradiso.2015.09.008},
  pages     = {13 -- 16},
  year      = {2016},
  abstract  = {[⁶⁸Ga(DOTATATE)] has demonstrated its clinical usefulness. Both Fe³⁺ and Cu²⁺, potential contaminants in Gallium-68 generator eluent, substantially reduce the radiochemical (RC) yield of [⁶⁸Ga(DOTATATE)] if the metal/ligand ratio of 1:1 is exceeded. A variety of compounds were examined for their potential ability to reduce this effect. Most had no effect on RC yield. However, addition of phosphate diminished the influence of Fe³⁺ by likely forming an insoluble iron salt. Addition of ascorbic acid reduced Cu²⁺ and Fe³⁺ to Cu⁺ and Fe²⁺ respectively, both of which have limited impact on RC yields. At low ligand amounts (5 nmol DOTATATE), the addition of 30 nmol phosphate (0.19 mM) increased the tolerance of Fe3⁺ from 4 nmol to 10 nmol (0.06 mM), while the addition of ascorbic acid allowed high RC yields (>95\%) in the presence of 40 nmol Fe³⁺ (0.25 mM) and 100 nmol Cu²⁺ (0.63 mM). The effect of ascorbic acid was highly pH-dependant, and gave optimal results at pH 3.},
  language  = {en}
}
@article{NiedermeyerZhouDursunetal.2016,
  author    = {Niedermeyer, Angela and Zhou, Bei and Dursun, G{\"o}zde and Temiz Artmann, Ayseg{\"u}l and Markert, Bernd},
  title     = {An examination of tissue engineered scaffolds in a bioreactor},
  series = {Proceedings in Applied Mathematics and Mechanics PAMM},
  volume    = {16},
  journal   = {Proceedings in Applied Mathematics and Mechanics PAMM},
  number    = {1},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {1617-7061},
  doi       = {10.1002/pamm.201610038},
  pages     = {99 -- 100},
  year      = {2016},
  abstract  = {Replacement tissues, designed to fill in articular cartilage defects, should exhibit the same properties as the native material. The aim of this study is to foster the understanding of, firstly, the mechanical behavior of the material itself and, secondly, the influence of cultivation parameters on cell seeded implants as well as on cell migration into acellular implants. In this study, acellular cartilage replacement material is theoretically, numerically and experimentally investigated regarding its viscoelastic properties, where a phenomenological model for practical applications is developed. Furthermore, remodeling and cell migration are investigated.},
  language  = {en}
}
@inproceedings{MoehringWulfhorstRothetal.2016,
  author    = {M{\"o}hring, S. and Wulfhorst, H. and Roth, J. and Tippk{\"o}tter, Nils},
  title     = {Pretreatment strategies for lignocellulosic biomass},
  series = {New frontiers of biotech-processes (Himmelfahrtstagung) : 02-04 May 2016, Rhein-Mosel-Halle, Koblenz/Germany},
  booktitle = {New frontiers of biotech-processes (Himmelfahrtstagung) : 02-04 May 2016, Rhein-Mosel-Halle, Koblenz/Germany},
  publisher = {DECHEMA},
  address   = {Frankfurt am Main},
  pages     = {131},
  year      = {2016},
  language  = {en}
}
@misc{MoehringWulfhorstCapitainetal.2016,
  author    = {M{\"o}hring, S. and Wulfhorst, H. and Capitain, C. and Roth, J. and Tippk{\"o}tter, Nils},
  title     = {Fractioning of lignocellulosic biomass: Scale-down and automation of thermal pretreatment for parameter optimization},
  series = {Chemie Ingenieur Technik},
  volume    = {88},
  journal   = {Chemie Ingenieur Technik},
  number    = {9},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {0009-286X},
  doi       = {10.1002/cite.201650288},
  pages     = {1229},
  year      = {2016},
  abstract  = {In order to efficiently convert lignocellulose, it is often necessary to conduct a pretreatment. The biomass considered in this study typically comprises of agricultural and horticultural residues, as well as beechwood. A very environmentally friendly method, namely, fungal pretreatment using white-rot fungi, leads to an enhanced enzymatic hydrolysis. In contrast to other processes presented, the energy input is extremely low. However, the fungal growth on the lignocellulosic substrates takes several weeks at least in order to be effective. Thus, the reduction of chemicals and energy for thermal processing is a target of our current research. Liquid hot water (LHW) and solvent-based pretreatment (OrganoSolv) require more complex equipment, as they depend on high temperatures (160 - 180 °C) and enhanced pressure (up to 20 bar). However, they prove to be promising processes in regard to the fractioning of lignocellulose. For optimal lignin recovery the parameters differ from those established in cellulose extraction. A novel screening system scaled down to a reaction volume of 100 mL has been developed and successfully tested for this purpose.},
  language  = {en}
}
@article{MolinnusSorichBartzetal.2016,
  author    = {Molinnus, Denise and Sorich, Maren and Bartz, Alexander and Siegert, Petra and Willenberg, Holger S. and Lisdat, Fred and Poghossian, Arshak and Keusgen, Michael and Sch{\"o}ning, Michael Josef},
  title     = {Towards an adrenaline biosensor based on substrate recycling amplification in combination with an enzyme logic gate},
  series = {Sensors and Actuators B: Chemical},
  volume    = {237},
  journal   = {Sensors and Actuators B: Chemical},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0925-4005},
  doi       = {10.1016/j.snb.2016.06.064},
  pages     = {190 -- 195},
  year      = {2016},
  abstract  = {An amperometric biosensor using a substrate recycling principle was realized for the detection of low adrenaline concentrations (1 nM) by measurements in phosphate buffer and Ringer's solution at pH 6.5 and pH 7.4, respectively. In proof-of-concept experiments, a Boolean logic-gate principle has been applied to develop a digital adrenaline biosensor based on an enzyme AND logic gate. The obtained results demonstrate that the developed digital biosensor is capable for a rapid qualitative determination of the presence/absence of adrenaline in a YES/NO statement. Such digital biosensor could be used in clinical diagnostics for the control of a correct insertion of a catheter in the adrenal veins during adrenal venous-sampling procedure.},
  language  = {en}
}
@book{LauthKowalczyk2016,
  author    = {Lauth, Jakob and Kowalczyk, J{\"u}rgen},
  title     = {Einf{\"u}hrung in die Physik und Chemie der Grenzfl{\"a}chen und Kolloide},
  publisher = {Springer},
  address   = {Berlin},
  isbn      = {978-3-662-47018-3},
  doi       = {10.1007/978-3-662-47018-3},
  pages     = {Online-Ressource (XIX, 522 S., 341 Abb.)},
  year      = {2016},
  language  = {de}
}
@book{Lauth2016,
  author    = {Lauth, Jakob},
  title     = {Physikalische Chemie, 5: Elektrochemie},
  publisher = {Springer},
  address   = {Berlin},
  isbn      = {978-3-662-47559-1},
  pages     = {55 Seiten},
  year      = {2016},
  language  = {de}
}
@book{Lauth2016,
  author    = {Lauth, Jakob},
  title     = {Physikalische Chemie, 4: Reaktionskinetik},
  publisher = {Springer},
  address   = {Berlin},
  isbn      = {978-3-662-47674-1},
  pages     = {52 Seiten},
  year      = {2016},
  language  = {de}
}
@book{Lauth2016,
  author    = {Lauth, Jakob},
  title     = {Physikalische Chemie, 3: Phasengleichgewichte},
  publisher = {Springer},
  address   = {Berlin},
  isbn      = {978-3-662-47571-3},
  pages     = {57 Seiten},
  year      = {2016},
  language  = {de}
}
@book{Lauth2016,
  author    = {Lauth, Jakob},
  title     = {Physikalische Chemie, 2: Chemische Thermodynamik},
  publisher = {Springer},
  address   = {Berlin},
  isbn      = {978-3-662-47621-5},
  pages     = {77 Seiten},
  year      = {2016},
  language  = {de}
}
@book{Lauth2016,
  author    = {Lauth, Jakob},
  title     = {Physikalische Chemie, 1: Grundlagen der Thermodynamik und Verhalten der Gase},
  publisher = {Springer},
  address   = {Berlin},
  isbn      = {978-3-662-47676-5},
  pages     = {57 Seiten},
  year      = {2016},
  language  = {de}
}
@misc{KuthanAlKaidyTippkoetter2016,
  author    = {Kuthan, K. and Al-Kaidy, H. and Tippk{\"o}tter, Nils},
  title     = {Tropfenbasierte Enzymreaktionen auf Glasoberfl{\"a}chen im μL-Maßstab mit ortsaufgel{\"o}ster pL-Dosierung der Reaktanden},
  series = {Chemie Ingenieur Technik},
  volume    = {88},
  journal   = {Chemie Ingenieur Technik},
  number    = {9},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  doi       = {10.1002/cite.201650117},
  pages     = {1336 -- 1337},
  year      = {2016},
  abstract  = {Mit der Entwicklung w{\"a}ssriger Tropfen, die mit einer sch{\"u}tzenden H{\"u}lle magnetisierbarer, hydrophober Partikel umgeben sind, ergeben sich neue M{\"o}glichkeiten im Bereich der Mikrofluidik. So k{\"o}nnen die Tropfen als fl{\"u}ssige Mikroreaktoren eingesetzt werden. Der w{\"a}ssrige Kern dieser Mikroreaktoren besteht aus einer Substratl{\"o}sung f{\"u}r enzymatische Umsetzungen. Durch Bewegen der Mikroreaktoren k{\"o}nnen diese {\"u}ber immobilisierten Enzymen positioniert werden, um so einen enzymatischen Umsatz innerhalb der Mikroreaktoren zu realisieren. Hierf{\"u}r wurde eine neue Mikroreaktorplattform-Technologie etabliert. Die Mikroreaktoren k{\"o}nnen aufgrund ihrer magnetisierbaren H{\"u}llenpartikel {\"u}ber elektromagnetische Spulen bewegt werden. Die Bewegung erfolgt dabei mit einer automatisierten Aktuatorplattform, bestehend aus einer 3x3 Doppelspulenmatrix mit Magnetkernen. Als modellhaftes Reaktionssystem wird eine Enzymkaskade eingesetzt, die sich aus einer b-Glucosidase, Glucose-Oxidase und Meerrettichperoxidase zusammensetzt. Prim{\"a}r untersuchte Substrate sind Fluorescein-di-b-D-glucopyranoside, und 1-(3,7-Dihydroxy-10H-phenoxazin-10-yl)-ethanon, bei deren Umsatz fluoreszierende Produkte entstehen.},
  language  = {de}
}
@inproceedings{KasperSchiffelsKrafftetal.2016,
  author    = {Kasper, Katharina and Schiffels, Johannes and Krafft, Simone and Kuperjans, Isabel and Elbers, Gereon and Selmer, Thorsten},
  title     = {Biogas Production on Demand Regulated by Butyric Acid Addition},
  series = {IOP Conference Series: Earth and Environmental Science. Bd. 32},
  volume    = {32},
  booktitle = {IOP Conference Series: Earth and Environmental Science. Bd. 32},
  issn      = {1755-1315},
  doi       = {10.1088/1755-1315/32/1/012009},
  pages     = {012009/1 -- 012009/4},
  year      = {2016},
  language  = {en}
}
@article{InfantinoPaulssenMostaccietal.2016,
  author    = {Infantino, Angelo and Paulßen, Elisabeth and Mostacci, Domiziano and Schaffer, Paul and Trinczek, Michael and Hoehr, Cornelia},
  title     = {Assessment of the production of medical isotopes using the Monte Carlo code FLUKA: Simulations against experimental measurements},
  series = {Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms},
  volume    = {366},
  journal   = {Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1872-9584},
  doi       = {10.1016/j.nimb.2015.10.067},
  pages     = {117 -- 123},
  year      = {2016},
  abstract  = {The Monte Carlo code FLUKA is used to simulate the production of a number of positron emitting radionuclides, ¹⁸F, ¹³N, ⁹⁴Tc, ⁴⁴Sc, ⁶⁸Ga, ⁸⁶Y, ⁸⁹Zr, ⁵²Mn, ⁶¹Cu and ⁵⁵Co, on a small medical cyclotron with a proton beam energy of 13 MeV. Experimental data collected at the TR13 cyclotron at TRIUMF agree within a factor of 0.6 ± 0.4 with the directly simulated data, except for the production of ⁵⁵Co, where the simulation underestimates the experiment by a factor of 3.4 ± 0.4. The experimental data also agree within a factor of 0.8 ± 0.6 with the convolution of simulated proton fluence and cross sections from literature. Overall, this confirms the applicability of FLUKA to simulate radionuclide production at 13 MeV proton beam energy.},
  language  = {en}
}
@inproceedings{HeringUlberTippkoetter2016,
  author    = {Hering, T. and Ulber, Roland and Tippk{\"o}tter, Nils},
  title     = {Development of a screening system for antimicrobial surfaces},
  series = {New frontiers of biotech-processes (Himmelfahrtstagung) : 02-04 May 2016, Rhein-Mosel-Halle, Koblenz/Germany},
  booktitle = {New frontiers of biotech-processes (Himmelfahrtstagung) : 02-04 May 2016, Rhein-Mosel-Halle, Koblenz/Germany},
  publisher = {DECHEMA},
  address   = {Frankfurt am Main},
  pages     = {129},
  year      = {2016},
  language  = {en}
}
@misc{HeringUlberTippkoetter2016,
  author    = {Hering, T. and Ulber, Roland and Tippk{\"o}tter, Nils},
  title     = {Antimikrobielle Oberfl{\"a}chenmodifikation durch Mikropartikel},
  series = {Chemie Ingenieur Technik},
  volume    = {88},
  journal   = {Chemie Ingenieur Technik},
  number    = {9},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  doi       = {10.1002/cite.201650084},
  pages     = {1302},
  year      = {2016},
  abstract  = {Die Ausbildung von Biofilmen in technischen Anlagen, wie z. B. K{\"u}hlkreisl{\"a}ufen, Wasseraufbereitungssystemen und Bioreaktoren, f{\"u}hren zu Materialsch{\"a}den (Biofouling) und stark erh{\"o}htem Energieaufwand. Im Rahmen der aktuellen Forschungsarbeiten erfolgen aktive sowie passive Bio-Modifikationen auf funktionalisierten magnetischen Mikropartikelober-fl{\"a}chen. Um die verschiedenen funktionalisierten magnetischen Mikropartikel zu analysieren und ihre antimikrobielle Wirkung zu testen, wird der Einsatz einer 3D-gedruckten, magnetischen Plattform f{\"u}r ein Fluoreszenz-basiertes Screening-System untersucht. F{\"u}r den Oberfl{\"a}chenschutz wurden verschiedene, antimikrobiell funktionalisierte Partikelkombinationen mit dem Mikroorganismus Escherichia coli GFPmut2 in Bezug auf aktiven Oberfl{\"a}chenschutz verglichen. Um die antimikrobielle Oberfl{\"a}cheneffekte von synergistischen Kombinationen unterschiedlich funktionalisierter Partikel zu bestimmen, werden Oberfl{\"a}chen einem Magnetfeld ausgesetzt, das die Mikropartikel als definierte Schicht auf ihnen zur{\"u}ck h{\"a}lt. Diese modifizierten Oberfl{\"a}chen k{\"o}nnen sowohl durch Fluoreszenzspektroskopie als auch -mikroskopie analysiert werden.},
  language  = {de}
}