@article{BaeckerRakowskiPoghossianetal.2013,
  author    = {B{\"a}cker, Matthias and Rakowski, D. and Poghossian, Arshak and Biselli, Manfred and Wagner, Patrick and Sch{\"o}ning, Michael Josef},
  title     = {Chip-based amperometric enzyme sensor system for monitoring of bioprocesses by flow-injection analysis},
  series = {Journal of Biotechnology},
  volume    = {163},
  journal   = {Journal of Biotechnology},
  number    = {4},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0168-1656},
  doi       = {10.1016/j.jbiotec.2012.03.014},
  pages     = {371 -- 376},
  year      = {2013},
  abstract  = {A microfluidic chip integrating amperometric enzyme sensors for the detection of glucose, glutamate and glutamine in cell-culture fermentation processes has been developed. The enzymes glucose oxidase, glutamate oxidase and glutaminase were immobilized by means of cross-linking with glutaraldehyde on platinum thin-film electrodes integrated within a microfluidic channel. The biosensor chip was coupled to a flow-injection analysis system for electrochemical characterization of the sensors. The sensors have been characterized in terms of sensitivity, linear working range and detection limit. The sensitivity evaluated from the respective peak areas was 1.47, 3.68 and 0.28 μAs/mM for the glucose, glutamate and glutamine sensor, respectively. The calibration curves were linear up to a concentration of 20 mM glucose and glutamine and up to 10 mM for glutamate. The lower detection limit amounted to be 0.05 mM for the glucose and glutamate sensor, respectively, and 0.1 mM for the glutamine sensor. Experiments in cell-culture medium have demonstrated a good correlation between the glutamate, glutamine and glucose concentrations measured with the chip-based biosensors in a differential-mode and the commercially available instrumentation. The obtained results demonstrate the feasibility of the realized microfluidic biosensor chip for monitoring of bioprocesses.},
  language  = {en}
}
@inproceedings{HuckPoghossianBaeckeretal.2013,
  author    = {Huck, Christina and Poghossian, Arshak and B{\"a}cker, Matthias and Zander, W. and Schubert, J. and Sukoyan, L. H. and Begoyan, V. and Buniatyan, V. V. and Wagner, Patrick and Sch{\"o}ning, Michael Josef},
  title     = {Chemische Sensoren mit Bariumstrontiumtitanat als funktionelle Schicht zur Multiparameterdetektion},
  series = {11. Dresdner Sensor-Symposium : 9.-11.12.2013},
  booktitle = {11. Dresdner Sensor-Symposium : 9.-11.12.2013},
  organization    = {Dresdner Sensor-Symposium <11, 2013>},
  isbn      = {978-3-9813484-5-3},
  pages     = {368 -- 372},
  year      = {2013},
  language  = {de}
}
@article{PoghossianBerndsenSchoening2003,
  author    = {Poghossian, Arshak and Berndsen, Lars and Sch{\"o}ning, Michael Josef},
  title     = {Chemical sensor as physical sensor: ISFET-based flowvelocity, flow-direction and diffusion-coefficient sensor},
  series = {Sensors and Actuators B. 95 (2003), H. 1-3},
  journal   = {Sensors and Actuators B. 95 (2003), H. 1-3},
  isbn      = {0925-4005},
  pages     = {384 -- 390},
  year      = {2003},
  language  = {en}
}
@article{PoghossianBerndsenSchoening2002,
  author    = {Poghossian, Arshak and Berndsen, L. and Sch{\"o}ning, Michael Josef},
  title     = {Chemical sensor as a physical sensor: ISFET-based flowvelocity, flow-direction and diffusion-coefficient sensor},
  series = {Book of abstracts / ed. by J. Saneistr.},
  journal   = {Book of abstracts / ed. by J. Saneistr.},
  publisher = {Czech Technical University, Faculty of Electrical Engineering, Department of Measurement},
  address   = {Prague},
  isbn      = {80-01-02576-4},
  pages     = {649 -- 652},
  year      = {2002},
  language  = {en}
}
@article{YoshinobuEckenIsmailetal.2001,
  author    = {Yoshinobu, T. and Ecken, H. and Ismail, Md.A.B. and Iwasaki, H. and L{\"u}th, H. and Sch{\"o}ning, Michael Josef},
  title     = {Chemical imaging sensor and its application to biological systems},
  series = {Scaling down in electrochemistry : electrochemical micro- and nanosystem technology ; proceedings of the 3rd International Symposium on Electrochemical Microsystem Technologies, Garmisch-Patenkirchen, Germany, 11 - 15 September 2000 / ed. by J. W. Schultz},
  journal   = {Scaling down in electrochemistry : electrochemical micro- and nanosystem technology ; proceedings of the 3rd International Symposium on Electrochemical Microsystem Technologies, Garmisch-Patenkirchen, Germany, 11 - 15 September 2000 / ed. by J. W. Schultz},
  publisher = {Elsevier [u.a.]},
  address   = {Amsterdam [u.a.]},
  isbn      = {0-08-044014-2},
  pages     = {259 -- 263},
  year      = {2001},
  language  = {en}
}
@article{MiyamotoIchimuraWagneretal.2013,
  author    = {Miyamoto, Ko-ichiro and Ichimura, Hiroki and Wagner, Torsten and Sch{\"o}ning, Michael Josef and Yoshinobu, Tatsuo},
  title     = {Chemical imaging of the concentration profile of ion diffusion in a microfluidic channel},
  series = {Sensors and actuators. B: Chemical},
  volume    = {189},
  journal   = {Sensors and actuators. B: Chemical},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1873-3077 (E-Journal); 0925-4005 (Print)},
  doi       = {10.1016/j.snb.2013.04.057},
  pages     = {240 -- 245},
  year      = {2013},
  abstract  = {The chemical imaging sensor is a device to visualize the spatial distribution of chemical species based on the principle of LAPS (light-addressable potentiometric sensor), which is a field-effect chemical sensor based on semiconductor. In this study, the chemical imaging sensor has been applied to investigate the ion profile of laminar flows in a microfluidic channel. The chemical images (pH maps) were collected in a Y-shaped microfluidic channel while injecting HCl and NaCl solutions into two branches. From the chemical images, it was clearly observed that the injected solutions formed laminar flows in the channel. In addition, ion diffusion across the laminar flows was observed, and the diffusion coefficient could be derived by fitting the pH profiles to the Fick's equation.},
  language  = {en}
}
@article{MiyamotoIchimuraWagneretal.2012,
  author    = {Miyamoto, K. and Ichimura, H. and Wagner, Torsten and Yoshinobu, T. and Sch{\"o}ning, Michael Josef},
  title     = {Chemical Imaging of ion Diffusion in a Microfluidic Channel},
  series = {Procedia Engineering},
  journal   = {Procedia Engineering},
  number    = {47},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1877-7058},
  doi       = {10.1016/j.proeng.2012.09.289},
  pages     = {886 -- 889},
  year      = {2012},
  abstract  = {The chemical imaging sensor is a chemical sensor which is capable of visualizing the spatial distribution of chemical species in sample solution. In this study, a novel measurement system based on the chemical imaging sensor was developed to observe the inside of a Y-shaped microfluidic channel while injecting two sample solutions from two branches. From the collected chemical images, it was clearly observed that the injected solutions formed laminar flows in the microfluidic channel. In addition, ion diffusion across the laminar flows was observed. This label-free method can acquire quantitative data of ion distribution and diffusion in microfluidic devices, which can be used to determine the diffusion coefficients, and therefore, the molecular weights of chemical species in the sample solution.},
  language  = {en}
}
@article{MiyamotoKuwabaraKanohetal.2009,
  author    = {Miyamoto, K. and Kuwabara, Yohei and Kanoh, Shin'ichiro and Yoshinobu, Tatsuo and Wagner, Torsten and Sch{\"o}ning, Michael Josef},
  title     = {Chemical image scanner based on FDM-LAPS},
  series = {Sensors and Actuators B: Chemical. 137 (2009), H. 2},
  journal   = {Sensors and Actuators B: Chemical. 137 (2009), H. 2},
  publisher = {Elsevier},
  address   = {Amsterdam},
  isbn      = {0925-4005},
  pages     = {533 -- 538},
  year      = {2009},
  language  = {en}
}
@article{PoghossianSchoening2007,
  author    = {Poghossian, Arshak and Sch{\"o}ning, Michael Josef},
  title     = {Chemical and biological field-effect sensors for liquids - a status report},
  series = {Handbook of biosensors and biochips / ed. Robert S. Marks ... Bd. 1},
  journal   = {Handbook of biosensors and biochips / ed. Robert S. Marks ... Bd. 1},
  publisher = {Wiley},
  address   = {Chichester},
  isbn      = {978-0-470-01905-4},
  pages     = {395 -- 412},
  year      = {2007},
  language  = {en}
}
@article{KnobbeSchoeningPoghossianetal.2004,
  author    = {Knobbe, D.-T. and Sch{\"o}ning, Michael Josef and Poghossian, Arshak and Mourzina, Y.},
  title     = {Charakterisierung von kapazitiven EMISSensoren mittels Impedanzspektroskopie, Kapazit{\"a}ts-Spannungs- und Konstant-Kapazit{\"a}ts-Messung},
  series = {Sensoren und Messsysteme 2004 : Tagung Ludwigsburg, 15. und 16. M{\"a}rz 2004 / VDI-VDE-Gesellschaft Mess- und Automatisierungstechnik},
  journal   = {Sensoren und Messsysteme 2004 : Tagung Ludwigsburg, 15. und 16. M{\"a}rz 2004 / VDI-VDE-Gesellschaft Mess- und Automatisierungstechnik},
  publisher = {VDI},
  address   = {D{\"u}sseldorf},
  isbn      = {3-18-091829-2},
  pages     = {851 -- 854},
  year      = {2004},
  language  = {de}
}
@article{SchusserPoghossianBaeckeretal.2012,
  author    = {Schusser, Sebastian and Poghossian, Arshak and B{\"a}cker, Matthias and Leinhos, Marcel and Wagner, Patrick and Sch{\"o}ning, Michael Josef},
  title     = {Characterization of biodegradable polymers with capacitive field-effect sensors},
  series = {Sensors and actuators B: Chemical},
  volume    = {187},
  journal   = {Sensors and actuators B: Chemical},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0925-4005},
  doi       = {10.1016/j.snb.2012.07.099},
  pages     = {2 -- 7},
  year      = {2012},
  abstract  = {In vitro studies of the degradation kinetic of biopolymers are essential for the design and optimization of implantable biomedical devices. In the presented work, a field-effect capacitive sensor has been applied for the real-time and in situ monitoring of degradation processes of biopolymers for the first time. The polymer-covered field-effect sensor is, in principle, capable to detect any changes in bulk, surface and interface properties of the polymer induced by degradation processes. The feasibility of this approach has been experimentally proven by using the commercially available biomedical polymer poly(D,L-lactic acid) (PDLLA) as a model system. PDLLA films of different thicknesses were deposited on the Ta₂O₅-gate surface of the field-effect structure from a polymer solution by means of spin-coating method. The polymer-modified field-effect sensors have been characterized by means of capacitance-voltage and impedance-spectroscopy method. The degradation of the PDLLA was accelerated by changing the degradation medium from neutral (pH 7.2) to alkaline (pH 9) condition, resulting in drastic changes in the capacitance and impedance spectra of the polymer-modified field-effect sensor.},
  language  = {en}
}
@article{SchrothLuethHummeletal.2001,
  author    = {Schroth, P. and L{\"u}th, H. and Hummel, Hans E. and Sch{\"u}tz, S. and Sch{\"o}ning, Michael Josef},
  title     = {Characterising an insect antenna as a receptor for a biosensor by means of impedance spectroscopy},
  series = {Scaling down in electrochemistry : electrochemical micro- and nanosystem technology ; proceedings of the 3rd International Symposium on Electrochemical Microsystem Technologies, Garmisch-Patenkirchen, Germany, 11 - 15 September 2000 / ed. by J. W. Schultz},
  journal   = {Scaling down in electrochemistry : electrochemical micro- and nanosystem technology ; proceedings of the 3rd International Symposium on Electrochemical Microsystem Technologies, Garmisch-Patenkirchen, Germany, 11 - 15 September 2000 / ed. by J. W. Schultz},
  publisher = {Elsevier [u.a.]},
  address   = {Amsterdam [u.a.]},
  isbn      = {0-08-044014-2},
  pages     = {293 -- 297},
  year      = {2001},
  language  = {en}
}
@article{KirchnerReisertPuetzetal.2012,
  author    = {Kirchner, Patrick and Reisert, Steffen and P{\"u}tz, Patrick and Keusgen, Michael and Sch{\"o}ning, Michael Josef},
  title     = {Characterisation of polymeric materials as passivation layer for calorimetric H2O2 gas sensors},
  series = {Physica Status Solidi (a)},
  volume    = {209},
  journal   = {Physica Status Solidi (a)},
  number    = {5},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {1862-6319},
  doi       = {10.1002/pssa.201100773},
  pages     = {859 -- 863},
  year      = {2012},
  abstract  = {Calorimetric gas sensors for monitoring the H₂O₂ concentration at elevated temperatures in industrial sterilisation processes have been presented in previous works. These sensors are built up in form of a differential set-up of a catalytically active and passive temperature-sensitive structure. Although, various types of catalytically active dispersions have been studied, the passivation layer has to be established and therefore, chemically as well as physically characterised. In the present work, fluorinated ethylene propylene (FEP), perfluoralkoxy (PFA) and epoxy-based SU-8 photoresist as temperature-stable polymeric materials have been investigated for sensor passivation in terms of their chemical inertness against H₂O₂, their hygroscopic properties as well as their morphology. The polymeric materials were deposited via spin-coating on the temperature-sensitive structure, wherein spin-coated FEP and PFA show slight agglomerates. However, they possess a low absorption of humidity due to their hydrophobic surface, whereas the SU-8 layer has a closed surface but shows a slightly higher absorption of water. All of them were inert against gaseous H₂O₂ during the characterisation in H₂O₂ atmosphere that demonstrates their suitability as passivation layer for calorimetric H₂O₂ gas sensors.},
  language  = {en}
}
@article{AbouzarPoghossianRazavietal.2009,
  author    = {Abouzar, Maryam H. and Poghossian, Arshak and Razavi, A. and Williams, O. A. and Bijnens, N. and Wagner, P. and Sch{\"o}ning, Michael Josef},
  title     = {Characterisation of capacitive field-effect sensors with a nanocrystalline-diamond film as transducer material for multi-parameter sensing},
  series = {Biosensors and Bioelectronics. 24 (2009), H. 5},
  journal   = {Biosensors and Bioelectronics. 24 (2009), H. 5},
  publisher = {Elsevier},
  address   = {Amsterdam},
  isbn      = {0956-5663},
  pages     = {1298 -- 1304},
  year      = {2009},
  language  = {en}
}
@article{ReisertGeisslerFloerkeetal.2013,
  author    = {Reisert, Steffen and Geissler, Hanno and Fl{\"o}rke, Rudolf and Weiler, Christian and Wagner, Patrick and Sch{\"o}ning, Michael Josef},
  title     = {Characterisation of aseptic sterilisation processes using an electronic nose},
  series = {International journal of nanotechnology},
  volume    = {Vol. 10},
  journal   = {International journal of nanotechnology},
  number    = {No. 5-7},
  publisher = {Inderscience Enterprises},
  address   = {Gen{\`e}ve},
  issn      = {1475-7435 (Print) 7141-8151 (Online)},
  pages     = {470 -- 484},
  year      = {2013},
  language  = {en}
}
@article{KloockMourzinaYoshinobuetal.2002,
  author    = {Kloock, Joachim P. and Mourzina, Y.G. and Yoshinobu, T. and Schubert, J. and Sch{\"o}ning, Michael Josef},
  title     = {Chalkogenidglassensoren f{\"u}r die Schwermetallanalytik},
  series = {Sensoren und Mess-Systeme : Vortr{\"a}ge der 11. ITG/GMA-Fachtagung vom 11. bis 12. M{\"a}rz 2002 in Ludwigsburg / Veranst.: Informationstechnische Gesellschaft im VDE (ITG) ... Wiss. Tagungsleitung: C. D. Kohl ....},
  journal   = {Sensoren und Mess-Systeme : Vortr{\"a}ge der 11. ITG/GMA-Fachtagung vom 11. bis 12. M{\"a}rz 2002 in Ludwigsburg / Veranst.: Informationstechnische Gesellschaft im VDE (ITG) ... Wiss. Tagungsleitung: C. D. Kohl ....},
  publisher = {VDE-Verl.},
  address   = {Berlin [u.a.]},
  isbn      = {3-8007-2675-0},
  pages     = {395 -- 398},
  year      = {2002},
  language  = {de}
}
@article{SiqueiraAbouzarBaeckeretal.2009,
  author    = {Siqueira, Jos{\´e} R. Jr. and Abouzar, Maryam H. and B{\"a}cker, Matthias and Zucolotto, Valtencir and Poghossian, Arshak and Oliveira, Osvaldo N. Jr. and Sch{\"o}ning, Michael Josef},
  title     = {Carbon nanotubes in nanostructured films: Potential application as amperometric and potentiometric field-effect (bio-)chemical sensors},
  series = {physica status solidi (a) . 206 (2009), H. 3},
  journal   = {physica status solidi (a) . 206 (2009), H. 3},
  publisher = {Wiley},
  address   = {Weinheim},
  isbn      = {1862-6319},
  pages     = {462 -- 467},
  year      = {2009},
  language  = {en}
}
@article{SchollMoraisGabrieletal.2017,
  author    = {Scholl, Fabio and Morais, Paulo and Gabriel, Rayla and Sch{\"o}ning, Michael Josef and Siqueira, Jose Roberto, Jr. and Caseli, Luciano},
  title     = {Carbon nanotubes arranged as smart interfaces in lipid Langmuir-Blodgett films enhancing the enzymatic properties of penicillinase for biosensing applications},
  series = {Applied Materials \& Interfaces},
  volume    = {9},
  journal   = {Applied Materials \& Interfaces},
  number    = {36},
  publisher = {ACS},
  address   = {Washington},
  issn      = {1944-8252},
  doi       = {10.1021/acsami.7b08095},
  pages     = {31054 -- 31066},
  year      = {2017},
  abstract  = {In this paper, carbon nanotubes (CNTs) were incorporated in penicillinase-phospholipid Langmuir and Langmuir-Blodgett (LB) films to enhance the enzyme catalytic properties. Adsorption of the penicillinase and CNTs at dimyristoylphosphatidic acid (DMPA) monolayers at the air-water interface was investigated by surface pressure-area isotherms, vibrational spectroscopy, and Brewster angle microscopy. The floating monolayers were transferred to solid supports through the LB technique, forming mixed DMPA-CNTs-PEN films, which were investigated by quartz crystal microbalance, vibrational spectroscopy, and atomic force microscopy. Enzyme activity was studied with UV-vis spectroscopy and the feasibility of the supramolecular device nanostructured as ultrathin films were essayed in a capacitive electrolyte-insulator-semiconductor (EIS) sensor device. The presence of CNTs in the enzyme-lipid LB film not only tuned the catalytic activity of penicillinase but also helped conserve its enzyme activity after weeks, showing increased values of activity. Viability as penicillin sensor was demonstrated with capacitance/voltage and constant capacitance measurements, exhibiting regular and distinctive output signals over all concentrations used in this work. These results may be related not only to the nanostructured system provided by the film, but also to the synergism between the compounds on the active layer, leading to a surface morphology that allowed a fast analyte diffusion because of an adequate molecular accommodation, which also preserved the penicillinase activity. This work therefore demonstrates the feasibility of employing LB films composed of lipids, CNTs, and enzymes as EIS devices for biosensing applications.},
  language  = {en}
}
@article{RodriguesMoraisNordietal.2018,
  author    = {Rodrigues, Raul T. and Morais, Paulo V. and Nordi, Cristina S. F. and Sch{\"o}ning, Michael Josef and Siqueira Jr., Jos{\´e} R. and Caseli, Luciano},
  title     = {Carbon Nanotubes and Algal Polysaccharides To Enhance the Enzymatic Properties of Urease in Lipid Langmuir-Blodgett Films},
  series = {Langmuir},
  volume    = {34},
  journal   = {Langmuir},
  number    = {9},
  publisher = {ACS Publications},
  address   = {Washington, DC},
  issn      = {1520-5827},
  doi       = {10.1021/acs.langmuir.7b04317},
  pages     = {3082 -- 3093},
  year      = {2018},
  abstract  = {Algal polysaccharides (extracellular polysaccharides) and carbon nanotubes (CNTs) were adsorbed on dioctadecyldimethylammonium bromide Langmuir monolayers to serve as a matrix for the incorporation of urease. The physicochemical properties of the supramolecular system as a monolayer at the air-water interface were investigated by surface pressure-area isotherms, surface potential-area isotherms, interfacial shear rheology, vibrational spectroscopy, and Brewster angle microscopy. The floating monolayers were transferred to hydrophilic solid supports, quartz, mica, or capacitive electrolyte-insulator-semiconductor (EIS) devices, through the Langmuir-Blodgett (LB) technique, forming mixed films, which were investigated by quartz crystal microbalance, fluorescence spectroscopy, and field emission gun scanning electron microscopy. The enzyme activity was studied with UV-vis spectroscopy, and the feasibility of the thin film as a urea sensor was essayed in an EIS sensor device. The presence of CNT in the enzyme-lipid LB film not only tuned the catalytic activity of urease but also helped to conserve its enzyme activity. Viability as a urease sensor was demonstrated with capacitance-voltage and constant capacitance measurements, exhibiting regular and distinctive output signals over all concentrations used in this work. These results are related to the synergism between the compounds on the active layer, leading to a surface morphology that allowed fast analyte diffusion owing to an adequate molecular accommodation, which also preserved the urease activity. This work demonstrates the feasibility of employing LB films composed of lipids, CNT, algal polysaccharides, and enzymes as EIS devices for biosensing applications.},
  language  = {en}
}
@article{HuckPoghossianBaeckeretal.2014,
  author    = {Huck, Christina and Poghossian, Arshak and B{\"a}cker, Matthias and Chaudhuri, S. and Zander, W. and Schubert, J. and Begoyan, V. K. and Buniatyan, V. V. and Wagner, P. and Sch{\"o}ning, Michael Josef},
  title     = {Capacitively coupled electrolyte-conductivity sensor based on high-k material of barium strontium titanate},
  series = {Sensors and actuators. B: Chemical},
  journal   = {Sensors and actuators. B: Chemical},
  number    = {198},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1873-3077 (E-Journal); 0925-4005 (Print)},
  doi       = {10.1016/j.snb.2014.02.103},
  pages     = {102 -- 109},
  year      = {2014},
  language  = {en}
}