@incollection{MatchaKarzelPahl2013, author = {Matcha, Heike and Karzel, R{\"u}diger and Pahl, Katja-Annika}, title = {Lehre als Praxis als Forschung: 1:1 Entwicklung von Messest{\"a}nden unter Einsatz parametrisierter Software und computergesteuerter Herstellung}, series = {ECHT?! Zum Bezug von Praxis und Lehre in der Architekturausbildung}, booktitle = {ECHT?! Zum Bezug von Praxis und Lehre in der Architekturausbildung}, publisher = {TUDpress - Verlag der Wissenschaften}, address = {Dresden}, isbn = {978-3-94433111-9}, pages = {95 -- 108}, year = {2013}, language = {de} } @article{ScheerWolf2013, author = {Scheer, Nico and Wolf, C. Roland}, title = {Xenobiotic receptor humanized mice and their utility}, series = {Drug Metabolism Reviews}, journal = {Drug Metabolism Reviews}, number = {1}, publisher = {Taylor \& Francis}, address = {London}, issn = {1097-9883}, doi = {10.3109/03602532.2012.738687}, pages = {110 -- 121}, year = {2013}, language = {en} } @phdthesis{Geenen2013, author = {Geenen, Eva-Maria}, title = {Studies of Epstein-Barr virus EBNA2 and its interactions with host cell factors}, publisher = {Universit{\´e} de Grenoble}, address = {Grenoble}, pages = {125 S.}, year = {2013}, language = {en} } @inproceedings{DupratDachwaldHilchenbachetal.2013, author = {Duprat, J. and Dachwald, Bernd and Hilchenbach, M. and Engrand, Cecile and Espe, C. and Feldmann, M. and Francke, G. and G{\"o}r{\"o}g, Mark and L{\"u}sing, N. and Langenhorst, Falko}, title = {The MARVIN project: a micrometeorite harvester in Antarctic snow}, series = {44th Lunar and Planetary Science Conference}, booktitle = {44th Lunar and Planetary Science Conference}, year = {2013}, abstract = {MARVIN is an automated drilling and melting probe dedicated to collect pristine interplanetary dust particles (micrometeorites) from central Antarctica snow.}, language = {en} } @incollection{StangelMesekeHahnSteuerDankert2013, author = {Stangel-Meseke, Martina and Hahn, Pia and Steuer-Dankert, Linda}, title = {Balance durch Diversity Management : L{\"o}sungsans{\"a}tze f{\"u}r unternehmerische Herausforderungen aus Megatrends}, series = {Balance Management}, booktitle = {Balance Management}, publisher = {Springer Gabler}, address = {Wiesbaden}, isbn = {978-3-658-02191-7}, doi = {10.1007/978-3-658-02192-4_6}, pages = {145 -- 166}, year = {2013}, abstract = {Unsere unternehmerische Umwelt befindet sich in einem zunehmend dynamischen Wandel. Dies f{\"u}hrt dazu, dass Herausforderungen, denen sich Unternehmen stellen m{\"u}ssen, immer komplexer werden. Hier gilt es zunehmend, eine Balance zwischen verschiedenen Spannungsfeldern zu erreichen. Sogenannte Megatrends stellen die Treiber dieses Wandels dar. Als Megatrend werden nach dem Zukunftsinstitut (2010a) richtungsweisende Ver{\"a}nderungstendenzen aufgefasst, die alle Bereiche des Lebens sowohl individuell als auch gesellschaftlich beeinflussen und langfristige Auswirkungen haben.}, language = {de} } @inproceedings{ChurilovDumovaJovanoskaButenweg2013, author = {Churilov, Sergej and Dumova-Jovanoska, Elena and Butenweg, Christoph}, title = {Seismic verification of existing masonry buildings and strengthening with reinforced concrete jackets}, series = {Proceedings - Vienna Congress on Recent Advances in Earthquake Engineering and Structural Dynamics 2013 (VEESD 2013)}, booktitle = {Proceedings - Vienna Congress on Recent Advances in Earthquake Engineering and Structural Dynamics 2013 (VEESD 2013)}, editor = {Adam, Christoph and Heuer, Rudolf and Lenhardt, Wolfgang and Schranz, Christian}, isbn = {978-3-902749-04-8}, year = {2013}, abstract = {A methodology for assessment, seismic verification and strengthening of existing masonry buildings is presented in this paper. The verification is performed using a calculation model calibrated with the results from ambient vibration measurements. The calibrated model serves as an input for a deformation-based verification procedure based on the Capacity Spectrum Method (CSM). The bearing capacity of the building is calculated from experimental capacity curves of the individual walls idealized with bilinear elastic-perfectly plastic curves. The experimental capacity curves were obtained from in-plane cyclic loading tests on unreinforced and strengthened masonry walls with reinforced concrete jackets. The seismic action is compared with the load-bearing capacity of the building considering non-linear material behavior with its post-peak capacity. The application of the CSM to masonry buildings and the influence of a traditional strengthening method are demonstrated on the example of a public school building in Skopje, Macedonia.}, language = {en} } @inproceedings{ButenwegNorda2013, author = {Butenweg, Christoph and Norda, Hannah}, title = {Nonlinear analysis of masonry structures according to Eurocode 8}, series = {Proceedings - Vienna Congress on Recent Advances in Earthquake Engineering and Structural Dynamics 2013 (VEESD 2013)}, booktitle = {Proceedings - Vienna Congress on Recent Advances in Earthquake Engineering and Structural Dynamics 2013 (VEESD 2013)}, editor = {Adam, Christoph and Heuer, Rudolf and Lenhardt, Wolfgang and Schranz, Christian}, isbn = {978-3-902749-04-8}, year = {2013}, language = {en} } @inproceedings{AltayButenwegKlinkel2013, author = {Altay, Okyay and Butenweg, Christoph and Klinkel, Sven}, title = {Vibration control of slender structures by semi-active tuned liquid column dampers}, series = {Conference of the ASCE Engineering Mechanics Institute , Evanston, IL , USA , EMI 2013 , 2013-08-04 - 2013-08-07}, booktitle = {Conference of the ASCE Engineering Mechanics Institute , Evanston, IL , USA , EMI 2013 , 2013-08-04 - 2013-08-07}, pages = {1 Seite}, year = {2013}, language = {en} } @article{ReisertSchneiderGeissleretal.2013, author = {Reisert, Steffen and Schneider, Benno and Geissler, Hanno and Gompel, Matthias van and Wagner, Patrick and Sch{\"o}ning, Michael Josef}, title = {Multi-sensor chip for the investigation of different types of metal oxides for the detection of H2O2 in the ppm range}, series = {physica status solidi (a)}, volume = {210}, journal = {physica status solidi (a)}, number = {5}, publisher = {Wiley}, address = {Weinheim}, issn = {1862-6319}, pages = {898 -- 904}, year = {2013}, abstract = {In this work, a multi-sensor chip for the investigation of the sensing properties of different types of metal oxides towards hydrogen peroxide in the ppm range is presented. The fabrication process and physical characterization of the multi-sensor chip are described. Pure SnO2 and WO3 as well as Pd- and Pt-doped SnO2 films are characterized in terms of their sensitivity to H2O2. The sensing films have been prepared by drop-coating of water-dispensed nano-powders. A physical characterization, including scanning electron microscopy and X-ray diffraction analysis of the deposited metal-oxide films, was done. From the measurements in hydrogen peroxide atmosphere, it could be shown, that all of the tested metal oxide films are suitable for the detection of H2O2 in the ppm range. The highest sensitivity and reproducibility was achieved using Pt-doped SnO2. Calibration plot of a SnO2, WO3, Pt-, and Pd-doped SnO2 gas sensor for H2O2 concentrations in the ppm range.}, language = {en} } @article{WernerTakenagaTakietal.2013, author = {Werner, Frederik and Takenaga, Shoko and Taki, Hidenori and Sawada, Kazuaki and Sch{\"o}ning, Michael Josef}, title = {Comparison of label-free ACh-imaging sensors based on CCD and LAPS}, series = {Sensors and Actuators B: Chemical (2012)}, volume = {177}, journal = {Sensors and Actuators B: Chemical (2012)}, publisher = {Elsevier}, address = {Amsterdam}, isbn = {0925-4005}, pages = {745 -- 752}, year = {2013}, abstract = {Semiconductor-based chemical imaging sensors, like the light-addressable potentiometric sensor (LAPS) or the pH-imaging sensor based on a charge-coupled device (CCD), are becoming a powerful tool for label-free imaging of biological phenomena. We have proposed a polyion-based enzymatic membrane to develop an acetylcholine (ACh) imaging sensor for neural cell-activity observations. In this study, a CCD-type ACh-imaging sensor and a LAPS-type ACh-imaging sensor were fabricated and the prospect of both sensors was clarified by making a comparison of their basic characteristics.}, language = {en} } @incollection{Blome2013, author = {Blome, Hans-Joachim}, title = {Die Tragweite der physikalischen Kosmologie}, series = {Exploring Uncertainty}, booktitle = {Exploring Uncertainty}, publisher = {Springer Gabler}, address = {Wiesbaden}, isbn = {978-3-658-00897-0}, doi = {10.1007/978-3-658-00897-0_6}, pages = {105 -- 150}, year = {2013}, language = {de} } @incollection{BozakovSander2013, author = {Bozakov, Zdravko and Sander, Volker}, title = {OpenFlow: A Perspective for Building Versatile Networks}, series = {Network-Embedded Management and Applications}, booktitle = {Network-Embedded Management and Applications}, publisher = {Springer}, address = {New York, NY}, isbn = {978-1-4419-6769-5}, doi = {10.1007/978-1-4419-6769-5_11}, pages = {217 -- 245}, year = {2013}, language = {en} } @article{CzarneckiWinkelmannSpiliopoulou2013, author = {Czarnecki, Christian and Winkelmann, Axel and Spiliopoulou, Myra}, title = {Referenzprozessabl{\"a}ufe f{\"u}r Telekommunikationsunternehmen: Eine Erweiterung des eTOM-Modells}, series = {Wirtschaftsinformatik}, volume = {55}, journal = {Wirtschaftsinformatik}, number = {2}, publisher = {Springer Fachmedien}, address = {Wiesbaden}, issn = {1861-8936}, doi = {10.1007/s11576-013-0351-9}, pages = {83 -- 97}, year = {2013}, abstract = {Der Telekommunikationsmarkt erf{\"a}hrt substanzielle Ver{\"a}nderungen. Neue Gesch{\"a}ftsmodelle, innovative Dienstleistungen und Technologien erfordern Reengineering, Transformation und Prozessstandardisierung. Mit der Enhanced Telecom Operation Map (eTOM) bietet das TM Forum ein international anerkanntes de facto Referenz-Prozess-Framework basierend auf spezifischen Anforderungen und Auspr{\"a}gungen der Telekommunikationsindustrie an. Allerdings enth{\"a}lt dieses Referenz-Framework nur eine hierarchische Sammlung von Prozessen auf unterschiedlichen Abstraktionsebenen. Eine Kontrollsicht verstanden als sequenzielle Anordnung von Aktivit{\"a}ten und daraus resultierend ein realer Prozessablauf fehlt ebenso wie eine Ende-zu-Ende-Sicht auf den Kunden. In diesem Artikel erweitern wir das eTOM-Referenzmodell durch Referenzprozessabl{\"a}ufe, in welchen wir das Wissen {\"u}ber Prozesse in Telekommunikationsunternehmen abstrahieren und generalisieren. Durch die Referenzprozessabl{\"a}ufe werden Unternehmen bei dem strukturierten und transparenten (Re-)Design ihrer Prozesse unterst{\"u}tzt. Wir demonstrieren die Anwendbarkeit und N{\"u}tzlichkeit unserer Referenzprozessabl{\"a}ufe in zwei Fallstudien und evaluieren diese anhand von Kriterien f{\"u}r die Bewertung von Referenzmodellen. Die Referenzprozessabl{\"a}ufe wurden vom TM Forum in den Standard aufgenommen und als Teil von eTOM Version 9 ver{\"o}ffentlicht. Dar{\"u}ber hinaus diskutieren wir die Komponenten unseres Ansatzes, die auch außerhalb der Telekommunikationsindustrie angewandt werden k{\"o}nnen.}, language = {de} } @phdthesis{Czarnecki2013, author = {Czarnecki, Christian}, title = {Entwicklung einer referenzmodellbasierten Unternehmensarchitektur f{\"u}r die Telekommunikationsindustrie}, publisher = {Logos}, address = {Berlin}, isbn = {9783832535100}, pages = {230 Seiten}, year = {2013}, abstract = {Die Telekommunikationsindustrie hat in den letzten Jahrzehnten einen enormen Wandel vollzogen. F{\"u}r Telekommunikationsunternehmen erfordert dies fundamentale Umstrukturierungen von Strategie, Prozessen, Anwendungssystemen und Netzwerktechnologien. Dabei spielen Unternehmensarchitekturen und Referenzmodelle eine wichtige Rolle. Zwar existieren in der Praxis anerkannte Referenzmodelle, aber wie sind diese f{\"u}r eine systematische Transformation zu gestalten? Wie sieht eine konkrete L{\"o}sung f{\"u}r die Telekommunikationsindustrie aus? Als Antwort stellt Christian Czarnecki in seinem Buch eine referenzmodellbasierte Unternehmensarchitektur vor. Basierend auf einer umfangreichen Untersuchung von Transformationsprojekten werden Probleme und Anforderungen der Praxis identifiziert, f{\"u}r die mit Methoden der Unternehmenstransformation, Referenzmodellierung und Unternehmensarchitektur ein L{\"o}sungsvorschlag entwickelt und evaluiert wird. Dieser besteht u. a. aus detaillierten Anwendungsf{\"a}llen, Referenzprozessabl{\"a}ufen, einer Zuordnung von Prozessen zu Anwendungssystemen sowie Handlungsempfehlungen zur Virtualisierung. F{\"u}r Wissenschaftler und Studierende der Wirtschaftsinformatik zeigt das Buch neue Erkenntnisse einer anwendungsorientierten Referenzmodellierung. F{\"u}r Praktiker liefert es eine methodisch fundierte L{\"o}sung f{\"u}r die aktuellen Transformationsbedarfe der Telekommunikationsindustrie. Christian Czarnecki arbeitet seit 2004 als Unternehmensberater und hat viele Telekommunikationsunternehmen bei deren Transformation begleitet. In 2013 erfolgte die Promotion zum Doktoringenieur an der Otto-von-Guericke-Universit{\"a}t Magdeburg.}, language = {de} } @article{PoghossianWeilCherstvyetal.2013, author = {Poghossian, Arshak and Weil, M. and Cherstvy, A. G. and Sch{\"o}ning, Michael Josef}, title = {Electrical monitoring of polyelectrolyte multilayer formation by means of capacitive field-effect devices}, series = {Analytical and bioanalytical chemistry}, volume = {405}, journal = {Analytical and bioanalytical chemistry}, number = {20}, publisher = {Springer}, address = {Berlin}, issn = {1432-1130 ; 1618-2642}, doi = {10.1007/s00216-013-6951-9}, pages = {6425 -- 6436}, year = {2013}, abstract = {The semiconductor field-effect platform represents a powerful tool for detecting the adsorption and binding of charged macromolecules with direct electrical readout. In this work, a capacitive electrolyte-insulator-semiconductor (EIS) field-effect sensor consisting of an Al-p-Si-SiO2 structure has been applied for real-time in situ electrical monitoring of the layer-by-layer formation of polyelectrolyte (PE) multilayers (PEM). The PEMs were deposited directly onto the SiO2 surface without any precursor layer or drying procedures. Anionic poly(sodium 4-styrene sulfonate) and cationic weak polyelectrolyte poly(allylamine hydrochloride) have been chosen as a model system. The effect of the ionic strength of the solution, polyelectrolyte concentration, number and polarity of the PE layers on the characteristics of the PEM-modified EIS sensors have been studied by means of capacitance-voltage and constant-capacitance methods. In addition, the thickness, surface morphology, roughness and wettabilityof the PE mono- and multilayers have been characterised by ellipsometry, atomic force microscopy and water contact-angle methods, respectively. To explain potential oscillations on the gate surface and signal behaviour of the capacitive field-effect EIS sensor modified with a PEM, a simplified electrostatic model that takes into account the reduced electrostatic screening of PE charges by mobile ions within the PEM has been proposed and discussed.}, language = {en} } @article{HuckSchiffelsHerreraetal.2013, author = {Huck, Christina and Schiffels, Johannes and Herrera, Cony N. and Schelden, Maximilian and Selmer, Thorsten and Poghossian, Arshak and Baumann, Marcus and Wagner, Patrick and Sch{\"o}ning, Michael Josef}, title = {Metabolic responses of Escherichia coli upon glucose pulses captured by a capacitive field-effect sensor}, series = {Physica Status Solidi (A)}, volume = {210}, journal = {Physica Status Solidi (A)}, number = {5}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {0031-8965}, doi = {10.1002/pssa.201200900}, pages = {926 -- 931}, year = {2013}, abstract = {Living cells are complex biological systems transforming metabolites taken up from the surrounding medium. Monitoring the responses of such cells to certain substrate concentrations is a challenging task and offers possibilities to gain insight into the vitality of a community influenced by the growth environment. Cell-based sensors represent a promising platform for monitoring the metabolic activity and thus, the "welfare" of relevant organisms. In the present study, metabolic responses of the model bacterium Escherichia coli in suspension, layered onto a capacitive field-effect structure, were examined to pulses of glucose in the concentration range between 0.05 and 2 mM. It was found that acidification of the surrounding medium takes place immediately after glucose addition and follows Michaelis-Menten kinetic behavior as a function of the glucose concentration. In future, the presented setup can, therefore, be used to study substrate specificities on the enzymatic level and may as well be used to perform investigations of more complex metabolic responses. Conclusions and perspectives highlighting this system are discussed.}, language = {en} } @article{BaeckerRakowskiPoghossianetal.2013, author = {B{\"a}cker, Matthias and Rakowski, D. and Poghossian, Arshak and Biselli, Manfred and Wagner, Patrick and Sch{\"o}ning, Michael Josef}, title = {Chip-based amperometric enzyme sensor system for monitoring of bioprocesses by flow-injection analysis}, series = {Journal of Biotechnology}, volume = {163}, journal = {Journal of Biotechnology}, number = {4}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0168-1656}, doi = {10.1016/j.jbiotec.2012.03.014}, pages = {371 -- 376}, year = {2013}, abstract = {A microfluidic chip integrating amperometric enzyme sensors for the detection of glucose, glutamate and glutamine in cell-culture fermentation processes has been developed. The enzymes glucose oxidase, glutamate oxidase and glutaminase were immobilized by means of cross-linking with glutaraldehyde on platinum thin-film electrodes integrated within a microfluidic channel. The biosensor chip was coupled to a flow-injection analysis system for electrochemical characterization of the sensors. The sensors have been characterized in terms of sensitivity, linear working range and detection limit. The sensitivity evaluated from the respective peak areas was 1.47, 3.68 and 0.28 μAs/mM for the glucose, glutamate and glutamine sensor, respectively. The calibration curves were linear up to a concentration of 20 mM glucose and glutamine and up to 10 mM for glutamate. The lower detection limit amounted to be 0.05 mM for the glucose and glutamate sensor, respectively, and 0.1 mM for the glutamine sensor. Experiments in cell-culture medium have demonstrated a good correlation between the glutamate, glutamine and glucose concentrations measured with the chip-based biosensors in a differential-mode and the commercially available instrumentation. The obtained results demonstrate the feasibility of the realized microfluidic biosensor chip for monitoring of bioprocesses.}, language = {en} } @article{KirchnerOberlaenderSucoetal.2013, author = {Kirchner, Patrick and Oberl{\"a}nder, Jan and Suco, Henri-Pierre and Rysstad, Gunnar and Sch{\"o}ning, Michael Josef}, title = {Monitoring the microbicidal effectiveness of gaseous hydrogen peroxide in sterilisation processes by means of a calorimetric gas sensor}, series = {Food control}, volume = {31}, journal = {Food control}, number = {2}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0956-7135}, doi = {10.1016/j.foodcont.2012.11.048}, pages = {530 -- 538}, year = {2013}, abstract = {In the present work, a novel method for monitoring sterilisation processes with gaseous H2O2 in combination with heat activation by means of a specially designed calorimetric gas sensor was evaluated. Therefore, the sterilisation process was extensively studied by using test specimens inoculated with Bacillus atrophaeus spores in order to identify the most influencing process factors on its microbicidal effectiveness. Besides the contact time of the test specimens with gaseous H2O2 varied between 0.2 and 0.5 s, the present H2O2 concentration in a range from 0 to 8\% v/v (volume percent) had a strong influence on the microbicidal effectiveness, whereas the change of the vaporiser temperature, gas flow and humidity were almost negligible. Furthermore, a calorimetric H2O2 gas sensor was characterised in the sterilisation process with gaseous H2O2 in a wide range of parameter settings, wherein the measurement signal has shown a linear response against the H2O2 concentration with a sensitivity of 4.75 °C/(\% v/v). In a final step, a correlation model by matching the measurement signal of the gas sensor with the microbial inactivation kinetics was established that demonstrates its suitability as an efficient method for validating the microbicidal effectiveness of sterilisation processes with gaseous H2O2.}, language = {en} } @article{KirchnerOberlaenderSusoetal.2013, author = {Kirchner, Patrick and Oberl{\"a}nder, Jan and Suso, Henri-Pierre and Rysstad, Gunnar and Keusgen, Michael and Sch{\"o}ning, Michael Josef}, title = {Towards a wireless sensor system for real-time H2O2 monitoring in aseptic food processes}, series = {Physica status solidi (a)}, volume = {210}, journal = {Physica status solidi (a)}, number = {5}, publisher = {Wiley}, address = {Weinheim}, issn = {1862-6319}, doi = {10.1002/pssa.201200920}, pages = {877 -- 883}, year = {2013}, abstract = {A wireless sensor system based on the industrial ZigBee standard for low-rate wireless networking was developed that enables real-time monitoring of gaseous H2O2 during the package sterilization in aseptic food processes. The sensor system consists of a remote unit connected to a calorimetric gas sensor, which was already established in former works, and an external base unit connected to a laptop computer. The remote unit was built up by an XBee radio frequency (RF) module for data communication and a programmable system-on-chip controller to read out the sensor signal and process the sensor data, whereas the base unit is a second XBee RF module. For the rapid H2O2 detection on various locations inside the package that has to be sterilized, a novel read-out strategy of the calorimetric gas sensor was established, wherein the sensor response is measured within the short sterilization time and correlated with the present H2O2 concentration. In an exemplary measurement application in an aseptic filling machinery, the suitability of the new, wireless sensor system was demonstrated, wherein the influence of the gas velocity on the H2O2 distribution inside a package was determined and verified with microbiological tests.}, language = {en} } @article{HennemannKohlReisertetal.2013, author = {Hennemann, J{\"o}rg and Kohl, Claus-Dieter and Reisert, Steffen and Kirchner, Patrick and Sch{\"o}ning, Michael Josef}, title = {Copper oxide nanofibres for detection of hydrogen peroxide vapour at high concentrations}, series = {physica status solidi (a)}, volume = {210}, journal = {physica status solidi (a)}, number = {5}, publisher = {Wiley}, address = {Weinheim}, issn = {1862-6319}, doi = {10.1002/pssa.201200775}, pages = {859 -- 863}, year = {2013}, abstract = {We present a sensor concept based on copper(II)oxide (CuO) nanofibres for the detection of hydrogen peroxide (H2O2) vapour in the percent per volume (\% v/v) range. The fibres were produced by using the electrospinning technique. To avoid water condensation in the pores, the fibres were initially modified by an exposure to H2S to get an enclosed surface. By a thermal treatment at 350 °C the fibres were oxidised back to CuO. Thereby, the visible pores disappear which was verified by SEM analysis. The fibres show a decrease of resistance with increasing H2O2 concentration which is due to the fact that hydrogen peroxide is an oxidising gas and CuO a p-type semiconductor. The sensor shows a change of resistance within the minute range to the exposure until the maximum concentration of 6.9\% v/v H2O2. At operating temperatures below 450 °C the corresponding sensor response to a concentration of 4.1\% v/v increases. The sensor shows a good reproducibility of the signal at different measurements. CuO seems to be a suitable candidate for the detection of H2O2 vapour at high concentrations. Resistance behaviour of the sensor under exposure to H2O2 vapours between 2.3 and 6.9\% v/v at an operating temperature of 450 °C.}, language = {en} }