@incollection{Kotliar2021,
  author    = {Kotliar, Konstantin},
  title     = {Ocular rigidity: clinical approach},
  series = {Ocular Rigidity, Biomechanics and Hydrodynamics of the Eye},
  booktitle = {Ocular Rigidity, Biomechanics and Hydrodynamics of the Eye},
  editor    = {Pallikaris, I. and Tsilimbaris, M. K. and Dastiridou, A. I.},
  publisher = {Springer},
  address   = {Cham},
  isbn      = {978-3-030-64422-2},
  doi       = {10.1007/978-3-030-64422-2_2},
  pages     = {15 -- 43},
  year      = {2021},
  abstract  = {The term ocular rigidity is widely used in clinical ophthalmology. Generally it is assumed as a resistance of the whole eyeball to mechanical deformation and relates to biomechanical properties of the eye and its tissues. Basic principles and formulas for clinical tonometry, tonography and pulsatile ocular blood flow measurements are based on the concept of ocular rigidity. There is evidence for altered ocular rigidity in aging, in several eye diseases and after eye surgery. Unfortunately, there is no consensual view on ocular rigidity: it used to make a quite different sense for different people but still the same name. Foremost there is no clear consent between biomechanical engineers and ophthalmologists on the concept. Moreover ocular rigidity is occasionally characterized using various parameters with their different physical dimensions. In contrast to engineering approach, clinical approach to ocular rigidity claims to characterize the total mechanical response of the eyeball to its deformation without any detailed considerations on eye morphology or material properties of its tissues. Further to the previous chapter this section aims to describe clinical approach to ocular rigidity from the perspective of an engineer in an attempt to straighten out this concept, to show its advantages, disadvantages and various applications.},
  language  = {en}
}
@article{KotliarDrozdovaShamshinova2006,
  author    = {Kotliar, Konstantin and Drozdova, G. A. and Shamshinova, A. M.},
  title     = {Ocular hemodinamics and contemporary methods of its assessment.
 Part I. Ocular blood circulation and its quantitative estimation},
  series = {National journal Glaucoma},
  volume    = {Vol. 5},
  journal   = {National journal Glaucoma},
  number    = {No. 3},
  issn      = {2078-4104},
  pages     = {62 -- 73},
  year      = {2006},
  language  = {ru}
}
@article{KotliarDrozdovaShamshinova2007,
  author    = {Kotliar, Konstantin and Drozdova, G. A. and Shamshinova, A. M.},
  title     = {Ocular hemodinamics and contemporary methods of its assessment. Part III. Non-invasive methods of assessment of ocular blood flow. 2. Static and dynamic assessment of retinal vessel reaction to stimuli},
  series = {National Journal Glaucoma},
  volume    = {Vol. 6},
  journal   = {National Journal Glaucoma},
  number    = {No. 2},
  issn      = {2078-4104},
  pages     = {64 -- 71},
  year      = {2007},
  language  = {ru}
}
@article{KotliarDrozdovaShamshinova2007,
  author    = {Kotliar, Konstantin and Drozdova, G. A. and Shamshinova, A. M.},
  title     = {Ocular hemodinamics and contemporary methods of its assessment. Part III. Non-invasive methods of assessment of ocular blood flow. 1. Assessment of blood cell velocities and flow rates in intraocular vessels and vascular beds},
  series = {Journal of Glaucoma},
  volume    = {Vol. 6},
  journal   = {Journal of Glaucoma},
  number    = {1},
  issn      = {2078-4104},
  pages     = {61 -- 68},
  year      = {2007},
  language  = {ru}
}
@article{KotliarDrozdovaShamshinova2006,
  author    = {Kotliar, Konstantin and Drozdova, G. A. and Shamshinova, A. M.},
  title     = {Ocular hemodinamics and contemporary methods of its assessment. Part II. Invasive methods of assessment of ocular blood flow},
  series = {National Journal Glaucoma},
  volume    = {Vol. 5},
  journal   = {National Journal Glaucoma},
  number    = {No. 4},
  issn      = {2078-4104},
  pages     = {37 -- 49},
  year      = {2006},
  language  = {ru}
}
@article{DashevskyLanzlKotliar2011,
  author    = {Dashevsky, Alexey V. and Lanzl, Ines M. and Kotliar, Konstantin},
  title     = {Non-penetrating intracanalicular partial trabeculectomy via the ostia of Schlemm's canal},
  series = {Graefe's Archive for Clinical and Experimental Ophthalmology},
  volume    = {249},
  journal   = {Graefe's Archive for Clinical and Experimental Ophthalmology},
  number    = {4},
  publisher = {Springer},
  address   = {Berlin},
  issn      = {0721-832x},
  pages     = {565 -- 573},
  year      = {2011},
  language  = {en}
}
@article{AlbannaKotliarLuekeetal.2018,
  author    = {Albanna, Walid and Kotliar, Konstantin and L{\"u}ke, Jan Niklas and Alpdogan, Serdar and Conzen, Catharina and Lindauer, Ute and Clusmann, Hans and Hescheler, J{\"u}rgen and Vilser, Walthard and Schneider, Toni and Schubert, Gerrit Alexander},
  title     = {Non-invasive evaluation of neurovascular coupling in the murine retina by dynamic retinal vessel analysis},
  series = {Plos one},
  volume    = {13},
  journal   = {Plos one},
  number    = {10},
  publisher = {PLOS},
  address   = {San Francisco},
  doi       = {10.1371/journal.pone.0204689},
  pages     = {e0204689},
  year      = {2018},
  abstract  = {Background Impairment of neurovascular coupling (NVC) was recently reported in the context of subarachnoid hemorrhage and may correlate with disease severity and outcome. However, previous techniques to evaluate NVC required invasive procedures. Retinal vessels may represent an alternative option for non-invasive assessment of NVC. Methods A prototype of an adapted retinal vessel analyzer was used to assess retinal vessel diameter in mice. Dynamic vessel analysis (DVA) included an application of monochromatic flicker light impulses in predefined frequencies for evaluating NVC. All retinae were harvested after DVA and electroretinograms were performed. Results A total of 104 retinal scans were conducted in 21 male mice (90 scans). Quantitative arterial recordings were feasible only in a minority of animals, showing an emphasized reaction to flicker light impulses (8 mice; 14 scans). A characteristic venous response to flicker light, however, could observed in the majority of animals. Repeated measurements resulted in a significant decrease of baseline venous diameter (7 mice; 7 scans, p < 0.05). Ex-vivo electroretinograms, performed after in-vivo DVA, demonstrated a significant reduction of transretinal signaling in animals with repeated DVA (n = 6, p < 0.001). Conclusions To the best of our knowledge, this is the first non-invasive study assessing murine retinal vessel response to flicker light with characteristic changes in NVC. The imaging system can be used for basic research and enables the investigation of retinal vessel dimension and function in control mice and genetically modified animals.},
  language  = {en}
}
@article{AlbannaConzenWeissetal.2021,
  author    = {Albanna, Walid and Conzen, Catharina and Weiss, Miriam and Seyfried, Katharina and Kotliar, Konstantin and Schmidt, Tobias Philip and Kuerten, David and Hescheler, J{\"u}rgen and Bruecken, Anne and Schmidt-Trucks{\"a}ss, Arno and Neumaier, Felix and Wiesmann, Martin and Clusmann, Hans and Schubert, Gerrit Alexander},
  title     = {Non-invasive assessment of neurovascular coupling after aneurysmal subarachnoid hemorrhage: a prospective observational trial using retinal vessel analysis},
  series = {Frontiers in Neurology},
  volume    = {12},
  journal   = {Frontiers in Neurology},
  number    = {12},
  issn      = {1664-2295},
  doi       = {10.3389/fneur.2021.690183},
  pages     = {1 -- 15},
  year      = {2021},
  abstract  = {Delayed cerebral ischemia (DCI) is a common complication after aneurysmal subarachnoid hemorrhage (aSAH) and can lead to infarction and poor clinical outcome. The underlying mechanisms are still incompletely understood, but animal models indicate that vasoactive metabolites and inflammatory cytokines produced within the subarachnoid space may progressively impair and partially invert neurovascular coupling (NVC) in the brain. Because cerebral and retinal microvasculature are governed by comparable regulatory mechanisms and may be connected by perivascular pathways, retinal vascular changes are increasingly recognized as a potential surrogate for altered NVC in the brain. Here, we used non-invasive retinal vessel analysis (RVA) to assess microvascular function in aSAH patients at different times after the ictus.},
  language  = {en}
}
@article{BaumannSchwarzKotliaretal.2009,
  author    = {Baumann, Marcus and Schwarz, Sonja and Kotliar, Konstantin and Eynatten, Maximilian von and Trucksaess, Arno and Burckhardt, Klaus and Lutz, Jens and Heemann, Uwe and Lanzl, Ines},
  title     = {Non-diabetic chronic kidney disease influences retinal microvasculature},
  series = {Kidney and Blood Pressure Research},
  volume    = {32},
  journal   = {Kidney and Blood Pressure Research},
  number    = {6},
  publisher = {-},
  isbn      = {1423-0143},
  pages     = {428 -- 433},
  year      = {2009},
  language  = {en}
}
@article{MaierFeuchtWinklervonMohrenfelsetal.2011,
  author    = {Maier, M. M. and Feucht, N. and Winkler von Mohrenfels, C. and Kotliar, Konstantin and Fabian, E. and Lohmann, C. P.},
  title     = {Nahtlose Cerclage mit Skleratunnelfixation. Sutureless Encircling Band - Clinical Experience},
  series = {Klinische Monatsbl{\"a}tter f{\"u}r Augenheilkunde},
  volume    = {228},
  journal   = {Klinische Monatsbl{\"a}tter f{\"u}r Augenheilkunde},
  number    = {5},
  publisher = {Thieme},
  address   = {Stuttgart},
  isbn      = {0344-6360},
  pages     = {473 -- 476},
  year      = {2011},
  language  = {de}
}
@article{BurkhardtSchwarzPanetal.2009,
  author    = {Burkhardt, Klaus and Schwarz, Sonja and Pan, Chengrui and Stelter, Felix and Kotliar, Konstantin and Eynatten, Maxilian von and Sollinger, Daniel and Lanzl, Ines and Heemann, Uwe and Baumann, Marcus},
  title     = {Myeloid-related protein 8/14 complex describes microcirculatory alterations in patients with type 2 diabetes and nephropathy},
  series = {Cardiovascular Diabetology},
  volume    = {8},
  journal   = {Cardiovascular Diabetology},
  number    = {10},
  publisher = {-},
  isbn      = {1475-2840},
  pages     = {1 -- 8},
  year      = {2009},
  language  = {en}
}
@article{KotliarSvetlovaMakarovetal.2003,
  author    = {Kotliar, Konstantin and Svetlova, O. V. and Makarov, F. N. and Zaseeva, M. V.},
  title     = {Morfologicheskie i funktsional'nye osobennosti resnichnogo poiaska khrustalika kak kliuchevogo ispolnitel'nogo zvena v mekhanizme akkommodatsii glaza cheloveka = Morpho-functional characteristics of lens ciliary body as a key mechanism of accommodation in},
  series = {Morfologiia (Saint Petersburg, Russia). 123 (2003), H. 3},
  journal   = {Morfologiia (Saint Petersburg, Russia). 123 (2003), H. 3},
  publisher = {-},
  isbn      = {1026-3543},
  pages     = {7 -- 16},
  year      = {2003},
  language  = {en}
}
@article{FuestKotliarWalteretal.2014,
  author    = {Fuest, Matthias and Kotliar, Konstantin and Walter, Peter and Plange, Niklas},
  title     = {Monitoring intraocular pressure changes after intravitreal Ranibizumab injection using rebound tonometry},
  series = {Ophthalmic and physiological optics},
  volume    = {34},
  journal   = {Ophthalmic and physiological optics},
  number    = {4},
  publisher = {Wiley-Blackwell},
  address   = {Oxford},
  issn      = {1475-1313 (E-Journal); 0275-5408 (Print)},
  doi       = {10.1111/opo.12134},
  pages     = {438 -- 444},
  year      = {2014},
  language  = {en}
}
@article{AlbannaLuekeSchubertetal.2019,
  author    = {Albanna, Walid and L{\"u}ke, Jan Niklas and Schubert, Gerrit Alexander and Dibu{\´e}-Adjei, Maxine and Kotliar, Konstantin and Hescheler, J{\"u}rgen and Clusmann, Hans and Steiger, Hans-Jakob and H{\"a}nggi, Daniel and Kamp, Marcel A. and Schneider, Toni and Neumaier, Felix},
  title     = {Modulation of Ca v 2.3 channels by unconjugated bilirubin (UCB) - Candidate mechanism for UCB-induced neuromodulation and neurotoxicity},
  series = {Molecular and Cellular Neuroscience},
  volume    = {96},
  journal   = {Molecular and Cellular Neuroscience},
  number    = {4},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1044-7431},
  doi       = {10.1016/j.mcn.2019.03.003},
  pages     = {35 -- 46},
  year      = {2019},
  language  = {en}
}
@article{KotliarBauerZamuraev2006,
  author    = {Kotliar, Konstantin and Bauer, S. M. and Zamuraev, L. A.},
  title     = {Model of the transversely isotropic spherical layer for estimation of intraocular pressure changes after intravitreal injections / Bauer, S. M. ; Zamuraev, L. A. ; Kotliar, K. E.},
  series = {Rossiiskii zhurnal biomekhaniki = Russian Journal of biomechanics. 10 (2006), H. 2},
  journal   = {Rossiiskii zhurnal biomekhaniki = Russian Journal of biomechanics. 10 (2006), H. 2},
  publisher = {-},
  isbn      = {1812-5123},
  pages     = {41 -- 47},
  year      = {2006},
  language  = {en}
}
@article{KotliarLanzl2016,
  author    = {Kotliar, Konstantin and Lanzl, I. M.},
  title     = {Mit Statistik gemeistert: perfekte Augentropfen und idealer Screeningtest : M{\"o}glichkeiten und Grenzen statistischer Methoden beim Glaukom},
  series = {Der Ophthalmologe: Zeitschrift Der Deutschen Ophthalmologischen Gesellschaft},
  journal   = {Der Ophthalmologe: Zeitschrift Der Deutschen Ophthalmologischen Gesellschaft},
  number    = {113},
  publisher = {Springer},
  address   = {Berlin},
  issn      = {0941-293X},
  doi       = {10.1007/s00347-016-0312-y},
  pages     = {838 -- 843},
  year      = {2016},
  abstract  = {Hintergrund Die Anwendung und das Verst{\"a}ndnis von Statistik sind sehr wichtig f{\"u}r die biomedizinische Forschung und f{\"u}r die klinische Praxis. Dies gilt insbesondere auch zur Absch{\"a}tzung der M{\"o}glichkeiten unterschiedlichster Diagnostik- und Therapieoptionen beim Glaukom. Die scheinbare Komplexit{\"a}t der Statistik, die zum Teil dem „gesunden Menschenverstand" zu widersprechen scheint, zusammen mit der nur vorsichtigen Akzeptanz der Statistik bei vielen Medizinern k{\"o}nnen zu bewussten und unbewussten Manipulationen bei der Datendarstellung und -interpretation f{\"u}hren. Ziel der Arbeit Ziel ist die verst{\"a}ndliche Darstellung einiger typischer Fehler in der medizinisch-statistischen Datenbehandlung. Material und Methoden Anhand hypothetischer Beispiele aus der Glaukomdiagnostik erfolgen die Darstellung der Wirkung eines hypotensiven Medikamentes sowie die Beurteilung der Ergebnisse eines diagnostischen Tests. Es werden die typischsten statistischen Einsatzbereiche und Irrtumsquellen ausf{\"u}hrlich und verst{\"a}ndlich analysiert Ergebnisse Mechanismen von Datenmanipulation und falscher Dateninterpretation werden aufgekl{\"a}rt. Typische Irrtumsquellen bei der statistischen Auswertung und Datendarstellung werden dabei erl{\"a}utert. Schlussfolgerungen Die erl{\"a}uterten praktischen Beispiele zeigen die Notwendigkeit, die Grundlagen der Statistik zu verstehen und korrekt anwenden zu k{\"o}nnen. Fehlendes Grundlagenwissen und Halbwissen der medizinischen Statistik k{\"o}nnen zu folgenschweren Missverst{\"a}ndnissen und falschen Entscheidungen in der medizinischen Forschung, aber auch in der klinischen Praxis f{\"u}hren.},
  language  = {de}
}
@article{KotliarNagelVilseretal.2010,
  author    = {Kotliar, Konstantin and Nagel, Edgar and Vilser, Walthard and Seidova, Seid-Fatima and Lanzl, Ines},
  title     = {Microstructural alterations of retinal arterial blood column along the vessel axis in systemic hypertension},
  series = {Investigative Ophthalmology \& Visual Science, IOVS},
  volume    = {51},
  journal   = {Investigative Ophthalmology \& Visual Science, IOVS},
  number    = {4},
  publisher = {ARVO},
  address   = {Rockville, Md.},
  issn      = {0146-0404},
  doi       = {10.1167/iovs.09-3649},
  pages     = {2165 -- 2172},
  year      = {2010},
  abstract  = {Purpose: Image analysis by the retinal vessel analyzer (RVA) observes retinal vessels in their dynamic state online noninvasively along a chosen vessel segment. It has been found that high-frequency diameter changes in the retinal artery blood column along the vessel increase significantly in anamnestically healthy volunteers with increasing age and in patients with glaucoma during vascular dilation. This study was undertaken to investigate whether longitudinal sections of the retinal artery blood column are altered in systemic hypertension. Methods: Retinal arteries of 15 untreated patients with essential arterial hypertension (age, 50.9 ± 11.9 years) and of 15 age-matched anamnestically healthy volunteers were examined by RVA. After baseline assessment, a monochromatic luminance flicker (530-600 nm; 12.5 Hz; 20 s) was applied to evoke retinal vasodilation. Differences in amplitude and frequency of spatial artery blood column diameter change along segments (longitudinal arterial profiles) of 1 mm in length were measured and analyzed using Fourier transformation. Results: In the control group, average reduced power spectra (ARPS) of longitudinal arterial profiles did not differ when arteries changed from constriction to dilation. In the systemic hypertension group, ARPS during constriction, baseline, and restoration were identical and differed from ARPS during dilation (P < 0.05). Longitudinal arterial profiles in both groups showed significant dissimilitude at baseline and restoration (P < 0.05). Conclusions: The retinal artery blood column demonstrates microstructural alterations in systemic hypertension and is less irregular along the vessel axis during vessel dilation. These microstructural changes may be an indication of alterations in vessel wall rigidity, vascular endothelial function, and smooth muscle cells in this disease, leading to impaired perfusion and regulation.},
  language  = {en}
}
@article{NurispahicKotliarLanzl2008,
  author    = {Nurispahic, A. and Kotliar, Konstantin and Lanzl, I.},
  title     = {Messung der Akkommodation mittels optischer Biometrie},
  series = {Der Ophthalmologe},
  volume    = {105},
  journal   = {Der Ophthalmologe},
  number    = {4},
  publisher = {-},
  isbn      = {1433-0423},
  pages     = {369 -- 375},
  year      = {2008},
  language  = {de}
}
@article{MartinGonzalezKotliarRiosMartinezetal.2014,
  author    = {Martin-Gonzalez, Anabel and Kotliar, Konstantin and Rios-Martinez, Jorge and Lanzl, Ines and Navab, Nassir},
  title     = {Mediated-reality magnification for macular degeneration rehabilitation},
  series = {Journal of Modern Optics},
  volume    = {61},
  journal   = {Journal of Modern Optics},
  number    = {17},
  publisher = {Taylor \& Francis},
  address   = {London},
  issn      = {1362-3044},
  doi       = {10.1080/09500340.2014.936110},
  pages     = {1400 -- 1408},
  year      = {2014},
  language  = {en}
}
@article{LanzlKotliar2017,
  author    = {Lanzl, I. and Kotliar, Konstantin},
  title     = {K{\"o}nnen Anti-VEGF-Injektionen Glaukom oder okul{\"a}re Hypertension verursachen?},
  series = {Klinische Monatsbl{\"a}tter f{\"u}r Augenheilkunde},
  volume    = {234},
  journal   = {Klinische Monatsbl{\"a}tter f{\"u}r Augenheilkunde},
  number    = {2},
  publisher = {Thieme},
  address   = {Stuttgart},
  issn      = {0023-2165},
  doi       = {10.1055/s-0043-101819},
  pages     = {191 -- 193},
  year      = {2017},
  language  = {de}
}