@article{BongaertsBovenbergKraemeretal.2002, author = {Bongaerts, Johannes and Bovenberg, Roel and Kr{\"a}mer, Marco and M{\"u}ller, Ulrike and Raeven, Leon and Wubbolts, Marcel}, title = {Metabolic engineering to produce fine chemicals in Escherichia coli}, series = {Chemie - Ingenieur - Technik (CIT)}, volume = {Vol. 74}, journal = {Chemie - Ingenieur - Technik (CIT)}, number = {Iss. 5}, issn = {1522-2640 (E-Journal); 0009-286X (Print)}, pages = {694}, year = {2002}, language = {en} } @article{Golland2019, author = {Golland, Alexander}, title = {Gemeinsam einsam: Ein „Like" f{\"u}r die gemeinsame Verantwortlichkeit?}, series = {ZD Zeitschrift f{\"u}r Datenschutz}, volume = {9}, journal = {ZD Zeitschrift f{\"u}r Datenschutz}, number = {9}, editor = {Hoeren, Thomas and Schneider, Jochen and Selmayr, Martin and Spies, Axel and Wybitul, Tim}, publisher = {Beck}, address = {M{\"u}nchen}, isbn = {2192-5593}, pages = {381 -- 382}, year = {2019}, language = {de} } @article{BialonskiWellmerElgeretal.2006, author = {Bialonski, Stephan and Wellmer, J{\"o}rg and Elger, Christian E. and Lehnertz, Klaus}, title = {Interictal focus localization in neocortical lesional epilepsies with synchronization cluster analysis}, series = {Epilepsia}, volume = {47}, journal = {Epilepsia}, issn = {0013-9580}, pages = {36}, year = {2006}, language = {en} } @article{FerreinBoehnstedtLakemeyer2007, author = {Ferrein, Alexander and B{\"o}hnstedt, Lutz and Lakemeyer, Gerhard}, title = {Options in readylog reloaded -- generating decision-theoretic plan libraries in golog / B{\"o}hnstedt, Lutz ; Ferrein, Alexander ; Lakemeyer, Gerhard}, series = {KI 2007: advances in artificial intelligence : 30th Annual German Conference on AI, KI 2007, Osnabr{\"u}ck, Germany, September 10 - 13, 2007 ; proceedings}, journal = {KI 2007: advances in artificial intelligence : 30th Annual German Conference on AI, KI 2007, Osnabr{\"u}ck, Germany, September 10 - 13, 2007 ; proceedings}, publisher = {Springer}, address = {Berlin}, isbn = {978-3-540-74564-8}, pages = {352 -- 366}, year = {2007}, language = {en} } @article{GerigkMaassTakorsetal.2000, author = {Gerigk, M. and Maaß, D. and Takors, Ralf and Kreutzer, A. and Wandrey, Christian and Bongaerts, Johannes and Wubbolts, Marcel}, title = {Fermentative Herstellung von L-Phenylalanin im Fed-Batch Verfahren mit E. coli unter Einbindung eines integrierten Aufarbeitungsverfahrens}, series = {Chemie-Ingenieur-Technik (CIT)}, volume = {Vol. 72}, journal = {Chemie-Ingenieur-Technik (CIT)}, number = {Iss. 9}, issn = {1522-2640 (E-Journal); 0009-286X (Print)}, pages = {926 -- 927}, year = {2000}, language = {de} } @article{Heuermann1995, author = {Heuermann, Holger}, title = {LZY: A Self-Calibration Approach in Competition to the LRM Method for On-Wafer Measurements}, pages = {129 -- 136}, year = {1995}, language = {en} } @article{Golland2020, author = {Golland, Alexander}, title = {Datenschutzrechtliche Fragen personalisierter Preise — Herausforderungen von Algorithmen im Schnittbereich von Ethik, {\"O}konomie und Datenschutz}, series = {CR Computer und Recht}, volume = {36}, journal = {CR Computer und Recht}, number = {3}, publisher = {Verlag Dr. Otto Schmidt}, address = {K{\"o}ln}, isbn = {2194-4172}, doi = {10.9785/cr-2020-360313}, pages = {186 -- 194}, year = {2020}, language = {de} } @article{HeuermannStolleSchiek1995, author = {Heuermann, Holger and Stolle, Reinhard and Schiek, Burkhard}, title = {Auswertemethoden zur Praezisions-Entfernungsmessung mit FMCW-Systemen und deren Anwendung im Mikrowellenbereich}, series = {tm - Technisches Messen. 62. 1995 (1995), H. 2}, journal = {tm - Technisches Messen. 62. 1995 (1995), H. 2}, pages = {66 -- 73}, year = {1995}, language = {de} } @article{LaackRefischOhnsorgeetal.1984, author = {Laack, Walter van and Refisch, A. and Ohnsorge, J. and D{\"u}rselen, L.}, title = {Proximaler Femurteilersatz - Alternative zum Schaftwechsel zementfixierter H{\"u}ftendoprothesen}, series = {Orthop{\"a}dische Praxis. 20 (1984), H. 11}, journal = {Orthop{\"a}dische Praxis. 20 (1984), H. 11}, isbn = {0030-588x}, pages = {856}, year = {1984}, language = {de} } @article{Golland2018, author = {Golland, Alexander}, title = {Der r{\"a}umliche Anwendungsbereich der DS-GVO}, series = {DuD Datenschutz und Datensicherheit}, volume = {42}, journal = {DuD Datenschutz und Datensicherheit}, number = {6}, publisher = {Springer}, address = {Heidelberg}, isbn = {1862-2607}, pages = {351 -- 357}, year = {2018}, abstract = {Die Datenschutz-Grundverordnung (DS-GVO) regelt in ihrem Art. 3 das r{\"a}umlich anwendbare Datenschutzrecht und zielt dabei gerade auch auf Angebote nichteurop{\"a}ischer Diensteanbieter ab. Die bisherige Diskussion konzentriert sich bislang in erster Linie darauf, das eingef{\"u}hrte Marktortprinzip zu thematisieren; das weitgehend unangetastete Niederlassungsprinzip und vor allem die Probleme, die sich durch dessen unver{\"a}nderte Beibehaltung ergeben, werden dagegen nicht er{\"o}rtert. Der folgende Beitrag versucht sich an einer systematischen Analyse eines teils kontrovers, teils kaum diskutierten Themas.}, language = {de} } @article{WolfFoltzSchlicketal.2002, author = {Wolf, Martin R. and Foltz, Christian and Schlick, Christopher and Luczak, Holger}, title = {Development and evaluation of a groupware system to support chemical design processes / Wolf, Martin ; Foltz, Christian ; Schlick, Christopher ; Luczak, Holger}, series = {International Journal of Human-Computer Interaction . 14 (2002), H. 2}, journal = {International Journal of Human-Computer Interaction . 14 (2002), H. 2}, publisher = {-}, isbn = {1044-7318}, pages = {181 -- 198}, year = {2002}, language = {en} } @article{BongaertsZoschkeWeidneretal.1995, author = {Bongaerts, Johannes and Zoschke, Sascha and Weidner, Uwe and Linden, Gottfried}, title = {Transcriptional regulation of the proton translocating NADH}, series = {Molecular microbiology}, volume = {Vol. 16}, journal = {Molecular microbiology}, number = {Iss. 3}, issn = {1365-2958 (E-Journal); 0950-382x (Print)}, pages = {521 -- 534}, year = {1995}, language = {en} } @article{Staat1996, author = {Staat, Manfred}, title = {Problems and Chances for Probabilistic Fracture Mechanics in the Analysis of Steel Pressure Boundary Reliability}, series = {Technical feasibility and reliability of passive safety systems for nuclear power plants. Proceedings of an Advisory Group Meeting held in J{\"u}lich, 21-24 November 1994}, journal = {Technical feasibility and reliability of passive safety systems for nuclear power plants. Proceedings of an Advisory Group Meeting held in J{\"u}lich, 21-24 November 1994}, address = {Vienna}, pages = {43 -- 55}, year = {1996}, language = {en} } @article{Stulpe1988, author = {Stulpe, Werner}, title = {Conditional Expectations, Conditional Distributions, and A Posteriori Ensembles in Generalized Probability Theory}, series = {International Journal of Theoretical Physics. 27 (1988), H. 5}, journal = {International Journal of Theoretical Physics. 27 (1988), H. 5}, isbn = {1572-9575}, pages = {587 -- 611}, year = {1988}, language = {en} } @article{Laack1986, author = {Laack, Walter van}, title = {Allgemeine physiotherapeutische Behandlung nach H{\"u}ft- und Kniegelenkoperationen}, series = {Physiotherapie. 77 (1986), H. 2}, journal = {Physiotherapie. 77 (1986), H. 2}, isbn = {0031-9392}, pages = {68 -- 72}, year = {1986}, language = {de} } @article{Golland2019, author = {Golland, Alexander}, title = {Reichweite des "Joint Controllership": Neue Fragen der gemeinsamen Verantwortlichkeit}, series = {K\&R Kommunikation \& Recht}, volume = {22}, journal = {K\&R Kommunikation \& Recht}, number = {9}, publisher = {dfv Mediengruppe, Deutscher Fachverlag GmbH}, address = {Frankfurt am Main}, issn = {1434-6354}, pages = {533 -- 537}, year = {2019}, abstract = {Kein Urteil zum Datenschutzrecht sorgte im vergangenen Jahr f{\"u}r mehr panische Reaktionen als die Entscheidung des EuGH in der Rechtssache "Wirtschaftsakademie Schleswig-Holstein"(C-210/16). Das Urteil warf in datenschutzrechtlicher Literatur und {\"O}ffentlichkeit zahlreiche Fragen auf: Ist jetzt jeder "gemeinsam" Verantwortlicher? Was sind die Kriterien? Der EuGH hat k{\"u}rzlich in einem - dem allgemeinen Vernehmen nach aufsehenerregenden, de facto aber kaum {\"u}berraschenden - Urteil f{\"u}r Klarheit gesorgt. Dabei hat das Gericht jedoch einige Fragen offengelassen und neue Fragen aufgeworfen. Ein Blick auf alte und neue Herausforderungen in Kooperationsszenarien.}, language = {de} } @article{KarschuckPoghossianSeretal.2024, author = {Karschuck, Tobias and Poghossian, Arshak and Ser, Joey and Tsokolakyan, Astghik and Achtsnicht, Stefan and Wagner, Patrick and Sch{\"o}ning, Michael Josef}, title = {Capacitive model of enzyme-modified field-effect biosensors: Impact of enzyme coverage}, series = {Sensors and Actuators B: Chemical}, volume = {408}, journal = {Sensors and Actuators B: Chemical}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0925-4005 (Print)}, doi = {10.1016/j.snb.2024.135530}, pages = {12 Seiten}, year = {2024}, abstract = {Electrolyte-insulator-semiconductor capacitors (EISCAP) belong to field-effect sensors having an attractive transducer architecture for constructing various biochemical sensors. In this study, a capacitive model of enzyme-modified EISCAPs has been developed and the impact of the surface coverage of immobilized enzymes on its capacitance-voltage and constant-capacitance characteristics was studied theoretically and experimentally. The used multicell arrangement enables a multiplexed electrochemical characterization of up to sixteen EISCAPs. Different enzyme coverages have been achieved by means of parallel electrical connection of bare and enzyme-covered single EISCAPs in diverse combinations. As predicted by the model, with increasing the enzyme coverage, both the shift of capacitance-voltage curves and the amplitude of the constant-capacitance signal increase, resulting in an enhancement of analyte sensitivity of the EISCAP biosensor. In addition, the capability of the multicell arrangement with multi-enzyme covered EISCAPs for sequentially detecting multianalytes (penicillin and urea) utilizing the enzymes penicillinase and urease has been experimentally demonstrated and discussed.}, language = {en} } @article{MonakhovaDiehl2021, author = {Monakhova, Yulia and Diehl, Bernd W.K.}, title = {Novel approach of qNMR workflow by standardization using 2H integral: Application to any intrinsic calibration standard}, series = {Talanta}, volume = {222}, journal = {Talanta}, number = {Article number: 121504}, publisher = {Elsevier}, isbn = {0039-9140}, doi = {10.1016/j.talanta.2020.121504}, year = {2021}, abstract = {Quantitative nuclear magnetic resonance (qNMR) is routinely performed by the internal or external standardization. The manuscript describes a simple alternative to these common workflows by using NMR signal of another active nuclei of calibration compound. For example, for any arbitrary compound quantification by NMR can be based on the use of an indirect concentration referencing that relies on a solvent having both 1H and 2H signals. To perform high-quality quantification, the deuteration level of the utilized deuterated solvent has to be estimated. In this contribution the new method was applied to the determination of deuteration levels in different deuterated solvents (MeOD, ACN, CDCl3, acetone, benzene, DMSO-d6). Isopropanol-d6, which contains a defined number of deuterons and protons, was used for standardization. Validation characteristics (precision, accuracy, robustness) were calculated and the results showed that the method can be used in routine practice. Uncertainty budget was also evaluated. In general, this novel approach, using standardization by 2H integral, benefits from reduced sample preparation steps and uncertainties, and can be applied in different application areas (purity determination, forensics, pharmaceutical analysis, etc.).}, language = {en} } @article{MonakhovaDiehl2022, author = {Monakhova, Yulia and Diehl, Bernd W.K.}, title = {Multinuclear NMR screening of pharmaceuticals using standardization by 2H integral of a deuterated solvent}, series = {Journal of Pharmaceutical and Biomedical Analysis}, volume = {209}, journal = {Journal of Pharmaceutical and Biomedical Analysis}, number = {Article number: 114530}, publisher = {Elsevier}, isbn = {0731-7085}, doi = {10.1016/j.jpba.2021.114530}, year = {2022}, abstract = {NMR standardization approach that uses the 2H integral of deuterated solvent for quantitative multinuclear analysis of pharmaceuticals is described. As a proof of principle, the existing NMR procedure for the analysis of heparin products according to US Pharmacopeia monograph is extended to the determination of Na+ and Cl- content in this matrix. Quantification is performed based on the ratio of a 23Na (35Cl) NMR integral and 2H NMR signal of deuterated solvent, D2O, acquired using the specific spectrometer hardware. As an alternative, the possibility of 133Cs standardization using the addition of Cs2CO3 stock solution is shown. Validation characteristics (linearity, repeatability, sensitivity) are evaluated. A holistic NMR profiling of heparin products can now also be used for the quantitative determination of inorganic compounds in a single analytical run using a single sample. In general, the new standardization methodology provides an appealing alternative for the NMR screening of inorganic and organic components in pharmaceutical products.}, language = {en} } @article{OezsoyluKizildagSchoeningetal.2020, author = {{\"O}zsoylu, Dua and Kizildag, Sefa and Sch{\"o}ning, Michael Josef and Wagner, Torsten}, title = {Differential chemical imaging of extracellular acidification within microfluidic channels using a plasma-functionalized light-addressable potentiometric sensor (LAPS)}, series = {Physics in Medicine}, volume = {10}, journal = {Physics in Medicine}, number = {100030}, publisher = {Elsevier}, address = {Amsterdam}, issn = {2352-4510}, doi = {10.1016/j.phmed.2020.100030}, pages = {8}, year = {2020}, abstract = {Extracellular acidification is a basic indicator for alterations in two vital metabolic pathways: glycolysis and cellular respiration. Measuring these alterations by monitoring extracellular acidification using cell-based biosensors such as LAPS plays an important role in studying these pathways whose disorders are associated with numerous diseases including cancer. However, the surface of the biosensors must be specially tailored to ensure high cell compatibility so that cells can represent more in vivo-like behavior, which is critical to gain more realistic in vitro results from the analyses, e.g., drug discovery experiments. In this work, O2 plasma patterning on the LAPS surface is studied to enhance surface features of the sensor chip, e.g., wettability and biofunctionality. The surface treated with O2 plasma for 30 s exhibits enhanced cytocompatibility for adherent CHO-K1 cells, which promotes cell spreading and proliferation. The plasma-modified LAPS chip is then integrated into a microfluidic system, which provides two identical channels to facilitate differential measurements of the extracellular acidification of CHO-K1 cells. To the best of our knowledge, it is the first time that extracellular acidification within microfluidic channels is quantitatively visualized as differential (bio-)chemical images.}, language = {en} }