@incollection{SaldenFischerBarnat2016, author = {Salden, Peter and Fischer, Kathrin and Barnat, Miriam}, title = {Didaktische Studiengangentwicklung: Rahmenkonzepte und Praxisbeispiel}, series = {P{\"a}dagogische Hochschulentwicklung. Von der Programmierung zur Implementierung}, booktitle = {P{\"a}dagogische Hochschulentwicklung. Von der Programmierung zur Implementierung}, publisher = {Springer VS}, address = {Wiesbaden}, isbn = {978-3-658-12067-2}, doi = {10.1007/978-3-658-12067-2_9}, pages = {133 -- 149}, year = {2016}, abstract = {Die Studiengangentwicklung ist ein komplexer Prozess, in dem strukturelle Vorgaben beachtet, viele unterschiedliche Akteure/-innen einbezogen und nicht zuletzt angemessene didaktische L{\"o}sungen zum Erreichen der angestrebten Lernergebnisse gefunden werden m{\"u}ssen. Der vorliegende Text nimmt besonders den letzten Punkt in den Blick: Er zeigt, wie Studiengangentwicklung zu einem Thema der (Hochschul-)Didaktik geworden ist und wie sich der didaktische Ansatz von struktur- und prozessorientierten Ans{\"a}tzen unterscheidet, aber auch, wie er mit diesen zusammenh{\"a}ngt. An einem Beispiel aus dem Wirtschaftsingenieurwesen wird veranschaulicht, was didaktische Studiengangentwicklung in der Praxis ausmacht und wie eine konkrete Implementierung verlaufen kann. Auf dieser Grundlage wird abschließend ein erweitertes Modell der didaktischen Studiengangentwicklung vorgeschlagen.}, language = {de} } @article{SalpatiChuChenetal.2014, author = {Salpati, Laurent and Chu, Xiaoyan and Chen, Liangfu and Prasad, Bhagwat and Dallas, Shannon and Evers, Raymond and Mamaril-Fishman, Donna and Geier, Ethan G. and Kehler, Jonathan and Kunta, Jeevan and Mezler, Mario and Laplanche, Loic and Pang, Jodie and Soars, Matthew G. and Unadkat, Jashvant D. and van Waterschoot, Robert A.B. and Yabut, Jocelyn and Schinkel, Alfred H. and Scheer, Nico and Rode, Anja}, title = {Evaluation of organic anion transporting polypeptide 1B1 and 1B3 humanized mice as a translational model to study the pharmacokinetics of statins}, series = {Drug Metabolism and Disposition}, volume = {42}, journal = {Drug Metabolism and Disposition}, number = {8}, publisher = {ASPET}, address = {Bethesda, Md.}, issn = {1521-009X}, doi = {10.1124/dmd.114.057976}, pages = {1301 -- 1313}, year = {2014}, abstract = {Organic anion transporting polypeptide (Oatp) 1a/1b knockout and OATP1B1 and -1B3 humanized mouse models are promising tools for studying the roles of these transporters in drug disposition. Detailed characterization of these models will help to better understand their utility for predicting clinical outcomes. To advance this approach, we carried out a comprehensive analysis of these mouse lines by evaluating the compensatory changes in mRNA expression, quantifying the amounts of OATP1B1 and -1B3 protein by liquid chromatography-tandem mass spectrometry, and studying the active uptake in isolated hepatocytes and the pharmacokinetics of some prototypical substrates including statins. Major outcomes from these studies were 1) mostly moderate compensatory changes in only a few genes involved in drug metabolism and disposition, 2) a robust hepatic expression of OATP1B1 and -1B3 proteins in the respective humanized mouse models, and 3) functional activities of the human transporters in hepatocytes isolated from the humanized models with several substrates tested in vitro and with pravastatin in vivo. However, the expression of OATP1B1 and -1B3 in the humanized models did not significantly alter liver or plasma concentrations of rosuvastatin and pitavastatin compared with Oatp1a/1b knockout controls under the conditions used in our studies. Hence, although the humanized OATP1B1 and -1B3 mice showed in vitro and/or in vivo functional activity with some statins, further characterization of these models is required to define their potential use and limitations in the prediction of drug disposition and drug-drug interactions in humans.}, language = {en} } @book{Samm1989, author = {Samm, Doris}, title = {Suche nach skalaren und pseudoskalaren Teilchen am Kernreaktor Merlin der KFA J{\"u}lich}, pages = {109 S. : graph. Darst.}, year = {1989}, language = {de} } @article{Samm1994, author = {Samm, Doris}, title = {DUMAND and the search for high energy neutrino point sources / Samm, Doris [u.a.]}, series = {Trends in astroparticle physics / ed. by Peter Christian Bosetti}, journal = {Trends in astroparticle physics / ed. by Peter Christian Bosetti}, publisher = {Teubner}, address = {Stuttgart}, isbn = {3-8154-3017-8}, pages = {9 -- 20}, year = {1994}, language = {en} } @article{SammBackhausSuhr2002, author = {Samm, Doris and Backhaus, U. and Suhr, W.}, title = {Die Kundt´sche Methode zur Messung der Schallgeschwindigkeit - ein Beispiel f{\"u}r die multimediale Unterst{\"u}tzung der Praktikumsvorbereitung / Samm, D. ; Backhaus, U. ; Suhr, W.}, series = {CD zur Fr{\"u}hjahrstagung des Fachverbandes Didaktik der Physik in der Deutschen Physikalischen Gesellschaft / Nordmeier, Volkhard [Red.]}, journal = {CD zur Fr{\"u}hjahrstagung des Fachverbandes Didaktik der Physik in der Deutschen Physikalischen Gesellschaft / Nordmeier, Volkhard [Red.]}, publisher = {Lehmann}, address = {Berlin}, isbn = {3-936427-11-9}, pages = {Elektronische Ressource}, year = {2002}, language = {de} } @article{SammBosetti1990, author = {Samm, Doris and Bosetti, P.-C.}, title = {Testmessungen an einem grossflaechigen (Durchmesser 35 cm) Photomultiplier Test measurements of a large-area (diameter 35 cm) photomultiplier / Bosetti, P.-C.; ... Samm, D. [u.a.]}, series = {Verhandlungen der Deutschen Physikalischen Gesellschaft. 25 (1990), H. 1}, journal = {Verhandlungen der Deutschen Physikalischen Gesellschaft. 25 (1990), H. 1}, pages = {33 -- 33}, year = {1990}, language = {en} } @article{SammBosetti1990, author = {Samm, Doris and Bosetti, P.-C.}, title = {DUMAND und die Suche nach extraterrestrischen Neutrinos / DUMAND and the search for extraterrestrial neutrinos / Bosetti, P.-C.; ... Samm, D. [u.a.]}, series = {Verhandlungen der Deutschen Physikalischen Gesellschaft. 25 (1990), H. 1}, journal = {Verhandlungen der Deutschen Physikalischen Gesellschaft. 25 (1990), H. 1}, pages = {88 -- 88}, year = {1990}, language = {en} } @article{SammFaissnerFrenzeletal.1980, author = {Samm, Doris and Faissner, H. and Frenzel, E. and Heinrigs, W.}, title = {Limit on axion decay into an electron pair / H. Faissner, E. Frenzel, W. Heinrigs, A. Preussger, D. Samm und U. Samm}, series = {Physics Letters B. Vol. 96 (1980), H. Issues 1-2}, journal = {Physics Letters B. Vol. 96 (1980), H. Issues 1-2}, pages = {201 -- 205}, year = {1980}, language = {en} } @article{SammFaissnerFrenzeletal.1980, author = {Samm, Doris and Faissner, H. and Frenzel, E. and Heinrigs, W.}, title = {Observation of the two-photon decay of a light penetrating particle / H. Faissner, E. Frenzel, W. Heinrigs, A. Preussger, D. Samm und U. Samm}, series = {Physics Letters B. Vol. 103 (1980), H. Issues 3}, journal = {Physics Letters B. Vol. 103 (1980), H. Issues 3}, pages = {234 -- 240}, year = {1980}, language = {en} } @article{SammFaissnerGoettlicheretal.1988, author = {Samm, Doris and Faissner, H. and G{\"o}ttlicher, P. and Matela, H.}, title = {Suche nach skalaren und pseudoskalaren Teilchen am Kernreaktor Merlin der KFA Juelich / Faissner, H.; Goettlicher, P.; Matela, H.; Samm, D.}, series = {Verhandlungen der Deutschen Physikalischen Gesellschaft. 23 (1988), H. 5}, journal = {Verhandlungen der Deutschen Physikalischen Gesellschaft. 23 (1988), H. 5}, year = {1988}, language = {de} } @article{SammFaissnerGoettlicheretal.1992, author = {Samm, Doris and Faissner, H. and G{\"o}ttlicher, P. and Matela, H.}, title = {Search for scalar and pseudoscalar bosons emitted in nuclear decays via their interactions / Faissner, H.; Goettlicher, P. ; Matela, H. ; Samm, D.}, series = {Zeitschrift f{\"u}r Physik A Hadrons and Nuclei. 341 (1992), H. 3}, journal = {Zeitschrift f{\"u}r Physik A Hadrons and Nuclei. 341 (1992), H. 3}, pages = {359 -- 364}, year = {1992}, language = {en} } @article{SammFaissnerHeinrigsetal.1983, author = {Samm, Doris and Faissner, H. and Heinrigs, W. and Latsch, C.}, title = {Richtungsselektive Z{\"a}hleranordnung zur Messung der Masse Axion-{\"a}hnlicher Teilchen / Faissner, H. ; Heinrigs, W. ; Latsch, C.; Preussger, A.; Samm, D.}, series = {Verhandlungen der Deutschen Physikalischen Gesellschaft. 18 (1983), H. 6}, journal = {Verhandlungen der Deutschen Physikalischen Gesellschaft. 18 (1983), H. 6}, pages = {1213 -- 1213}, year = {1983}, language = {de} } @article{SammFaissnerHeinrigsetal.1989, author = {Samm, Doris and Faissner, H. and Heinrigs, W. and Preussger, A.}, title = {Search for the two-photon decay of a light penetrating particle from a 590 MeV proton beam dump / Faissner, H.; Heinrigs, W.; Preussger, A.; Reitz, J.; Samm, D. [u.a.]}, series = {Zeitschrift f{\"u}r Physik, C Particles and Fields. 44 (1989), H. 4}, journal = {Zeitschrift f{\"u}r Physik, C Particles and Fields. 44 (1989), H. 4}, pages = {557 -- 566}, year = {1989}, language = {en} } @book{SammFaissnerHenrigsetal.1982, author = {Samm, Doris and Faissner, H. and Henrigs, W. and Preussger, A.}, title = {Further evidence for the radiative decay of a light, penetrating particle / Faissner, H. ; Heinrigs, W. ; Preussger, A. ; Samm, D.}, publisher = {Technische Hochschule}, address = {Aachen}, pages = {16}, year = {1982}, language = {en} } @article{SammFaissnerMoersetal.1993, author = {Samm, Doris and Faissner, H. and Moers, T. and Priem, R.}, title = {Modular wall-less drift chamber for muon detection at the LHC / H. Faissner, Th. Moers, R. Priem, ... , D. Samm [u.a.]}, series = {Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. 330 (1993), H. 1-2}, journal = {Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. 330 (1993), H. 1-2}, pages = {76 -- 82}, year = {1993}, language = {en} } @book{SammHemme2004, author = {Samm, Doris and Hemme, Heinrich}, title = {Physikalische Denksportaufgaben}, publisher = {Klett}, address = {Stuttgart}, isbn = {3-12-772531-0}, year = {2004}, language = {de} } @book{SammHemme2006, author = {Samm, Doris and Hemme, Heinrich}, title = {Physikalische Denksportaufgaben / 1. Aufl., [Nachdr.].}, publisher = {Klett}, address = {Stuttgart}, isbn = {3-12-772531-0}, pages = {63 S. : Ill., graph. Darst.}, year = {2006}, language = {de} } @incollection{SamuelssonScheerWilsonetal.2017, author = {Samuelsson, K. and Scheer, Nico and Wilson, I. and Wolf, C.R. and Henderson, C.J.}, title = {Genetically Humanized Animal Models}, series = {Comprehensive Medicinal Chemistry III. 3rd Edition}, booktitle = {Comprehensive Medicinal Chemistry III. 3rd Edition}, editor = {Chackalamannil, Samuel}, publisher = {Elsevier}, address = {Saint Louis}, isbn = {978-0-12-803201-5}, doi = {10.1016/B978-0-12-409547-2.12376-5}, pages = {130 -- 149}, year = {2017}, abstract = {Genetically humanized mice for proteins involved in drug metabolism and toxicity and mice engrafted with human hepatocytes are emerging as promising in vivo models for improved prediction of the pharmacokinetic, drug-drug interaction, and safety characteristics of compounds in humans. This is an overview on the genetically humanized and chimeric liver-humanized mouse models, which are illustrated with examples of their utility in drug metabolism and toxicity studies. The models are compared to give guidance for selection of the most appropriate model by highlighting advantages and disadvantages to be carefully considered when used for studies in drug discovery and development.}, language = {en} } @book{Sander2003, author = {Sander, Volker}, title = {Design and evaluation of a bandwidth broker that provides network quality of service for grid applications}, publisher = {John von Neumann Institute for Computing (NIC)}, address = {J{\"u}lich}, isbn = {3-00-010002-4}, pages = {VIII, 184 S. : Ill., graph. Darst.}, year = {2003}, language = {en} } @book{Sander2004, author = {Sander, Volker}, title = {Optical Network Infrastructure for Grid / Simeonidou, Dimitra ... (ed.)}, publisher = {Global Grid Forum}, pages = {56 S.}, year = {2004}, language = {en} }