@article{SchifferFerrein2016,
  author    = {Schiffer, Stefan and Ferrein, Alexander},
  title     = {Decision-Theoretic Planning with Fuzzy Notions in GOLOG},
  series = {International Journal of Uncertainty, Fuzziness and Knowledge-Based Systems},
  volume    = {24},
  journal   = {International Journal of Uncertainty, Fuzziness and Knowledge-Based Systems},
  number    = {Issue Suppl. 2},
  publisher = {World Scientific},
  address   = {Singapur},
  issn      = {1793-6411},
  doi       = {10.1142/S0218488516400134},
  pages     = {123 -- 143},
  year      = {2016},
  abstract  = {In this paper we present an extension of the action language Golog that allows for using fuzzy notions in non-deterministic argument choices and the reward function in decision-theoretic planning. Often, in decision-theoretic planning, it is cumbersome to specify the set of values to pick from in the non-deterministic-choice-of-argument statement. Also, even for domain experts, it is not always easy to specify a reward function. Instead of providing a finite domain for values in the non-deterministic-choice-of-argument statement in Golog, we now allow for stating the argument domain by simply providing a formula over linguistic terms and fuzzy uents. In Golog's forward-search DT planning algorithm, these formulas are evaluated in order to find the agent's optimal policy. We illustrate this in the Diner Domain where the agent needs to calculate the optimal serving order.},
  language  = {en}
}
@article{ScheidweilerTriesch2016,
  author    = {Scheidweiler, Robert and Triesch, Eberhard},
  title     = {A note on the duality between matchings and vertex covers in balanced hypergraphs},
  series = {Journal of Combinatorial Optimization},
  volume    = {32},
  journal   = {Journal of Combinatorial Optimization},
  number    = {2},
  publisher = {Springer},
  address   = {Berlin},
  issn      = {1573-2886},
  doi       = {10.1007/s10878-015-9887-5},
  pages     = {639 -- 644},
  year      = {2016},
  abstract  = {We present a new Min-Max theorem for an optimization problem closely connected to matchings and vertex covers in balanced hypergraphs. The result generalizes Kőnig's Theorem (Berge and Las Vergnas in Ann N Y Acad Sci 175:32-40, 1970; Fulkerson et al. in Math Progr Study 1:120-132, 1974) and Hall's Theorem (Conforti et al. in Combinatorica 16:325-329, 1996) for balanced hypergraphs.},
  language  = {en}
}
@article{ScheerWilson2016,
  author    = {Scheer, Nico and Wilson, Ian D.},
  title     = {A comparison between genetically humanized and chimeric liver humanized mouse models for studies in drug metabolism and toxicity},
  series = {Drug Discovery Today},
  volume    = {21},
  journal   = {Drug Discovery Today},
  number    = {2},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1359-6446},
  doi       = {10.1016/j.drudis.2015.09.002},
  pages     = {250 -- 263},
  year      = {2016},
  abstract  = {Mice that have been genetically humanized for proteins involved in drug metabolism and toxicity and mice engrafted with human hepatocytes are emerging and promising in vivo models for an improved prediction of the pharmacokinetic, drug-drug interaction and safety characteristics of compounds in humans. The specific advantages and disadvantages of these models should be carefully considered when using them for studies in drug discovery and development. Here, an overview on the corresponding genetically humanized and chimeric liver humanized mouse models described to date is provided and illustrated with examples of their utility in drug metabolism and toxicity studies. We compare the strength and weaknesses of the two different approaches, give guidance for the selection of the appropriate model for various applications and discuss future trends and perspectives.},
  language  = {en}
}
@incollection{ScheerChuSalphatietal.2016,
  author    = {Scheer, Nico and Chu, Xiaoyan and Salphati, Laurent and Zamek-Gliszczynski, Maciej J.},
  title     = {Knockout and humanized animal models to study membrane transporters in drug development},
  series = {Drug Transporters: Volume 1: Role and Importance in ADME and Drug Development},
  booktitle = {Drug Transporters: Volume 1: Role and Importance in ADME and Drug Development},
  editor    = {Nicholls, Glynis},
  publisher = {Royal Society of Chemistry},
  address   = {Cambridge},
  isbn      = {978-1-78262-379-3},
  doi       = {10.1039/9781782623793-00298},
  pages     = {298 -- 332},
  year      = {2016},
  language  = {en}
}
@techreport{SansomLawsonTuchoetal.2016,
  author    = {Sansom, M. and Lawson, R.M. and Tucho, R. and Kendrick, C. and Ogden, R. and Resalati, S. and Garay, R. and D{\"o}ring, Bernd and Reger, V. and Gilbert, J. and Heikkinen, J. and Hemmila, K.},
  title     = {Building in active thermal mass into steel structures (BATIMASS) - EUR 28166EN},
  publisher = {Publications Office of the European Union},
  address   = {Luxembourg},
  organization    = {European Commission},
  isbn      = {978-92-79-63176-4},
  issn      = {1831-9424},
  doi       = {10.2777/25999},
  pages     = {147 Seiten},
  year      = {2016},
  abstract  = {The main objective of the BATIMASS project was to address how the energy balance in relatively lightweight steel buildings can be improved by building in 'active thermal mass' (ATM) into the building fabric. This was achieved through concept design, dynamic thermal modelling and testing of a number of potentially viable systems and concepts. A significant programme of thermal simulation modelling was undertaken utilising the thermally equivalent slab (TES) concept to model the passive thermal capacity effect of profiled, composite metal floor decks. It is apparent from the modelling results that thermal mass is a highly complex phenomenon which is highly dependent upon building type, occupancy patterns, climate and many other aspects of the building design and servicing strategy. The ATM systems developed, both conceptually and for prototype testing, focussed on water-cooled composite slabs, the Cofradal floor system and the phase change material (PCM) Energain. In addition to laboratory testing of prototypes, whole building monitoring was undertaken at the Kubik building in Spain and the RWTH test building in Germany. Advanced thermal modelling was also undertaken to estimate the likely benefits of the ATM concept designs developed and for comparison with the test results. In addition to thermal testing, structural tests were conducted on composite floor specimens incorporating embedded water pipes. This Final Report presents the results of the activities carried out under this RFCS contract RFSR CT 2012 00033. The work carried out is reported in six major sections corresponding to the technical Work Packages of the project. Only summaries of the work carried out are provided in this report; all work undertaken is fully reported in the formal project deliverables.},
  language  = {en}
}
@incollection{SaldenFischerBarnat2016,
  author    = {Salden, Peter and Fischer, Kathrin and Barnat, Miriam},
  title     = {Didaktische Studiengangentwicklung: Rahmenkonzepte und Praxisbeispiel},
  series = {P{\"a}dagogische Hochschulentwicklung. Von der Programmierung zur Implementierung},
  booktitle = {P{\"a}dagogische Hochschulentwicklung. Von der Programmierung zur Implementierung},
  publisher = {Springer VS},
  address   = {Wiesbaden},
  isbn      = {978-3-658-12067-2},
  doi       = {10.1007/978-3-658-12067-2_9},
  pages     = {133 -- 149},
  year      = {2016},
  abstract  = {Die Studiengangentwicklung ist ein komplexer Prozess, in dem strukturelle Vorgaben beachtet, viele unterschiedliche Akteure/-innen einbezogen und nicht zuletzt angemessene didaktische L{\"o}sungen zum Erreichen der angestrebten Lernergebnisse gefunden werden m{\"u}ssen. Der vorliegende Text nimmt besonders den letzten Punkt in den Blick: Er zeigt, wie Studiengangentwicklung zu einem Thema der (Hochschul-)Didaktik geworden ist und wie sich der didaktische Ansatz von struktur- und prozessorientierten Ans{\"a}tzen unterscheidet, aber auch, wie er mit diesen zusammenh{\"a}ngt. An einem Beispiel aus dem Wirtschaftsingenieurwesen wird veranschaulicht, was didaktische Studiengangentwicklung in der Praxis ausmacht und wie eine konkrete Implementierung verlaufen kann. Auf dieser Grundlage wird abschließend ein erweitertes Modell der didaktischen Studiengangentwicklung vorgeschlagen.},
  language  = {de}
}
@article{RoeschKratzHeringetal.2016,
  author    = {R{\"o}sch, C. and Kratz, F. and Hering, T. and Trautmann, S. and Umanskaya, N. and Tippk{\"o}tter, Nils and M{\"u}ller-Renno, C.M. and Ulber, Roland and Hannig, M. and Ziegler, C.},
  title     = {Albumin-lysozyme interactions: cooperative adsorption on titanium and enzymatic activity},
  series = {Colloids and Surfaces B: Biointerfaces},
  volume    = {149},
  journal   = {Colloids and Surfaces B: Biointerfaces},
  number    = {1},
  publisher = {Elsevier},
  address   = {Amsterdam},
  doi       = {10.1016/j.colsurfb.2016.09.048},
  pages     = {115 -- 121},
  year      = {2016},
  abstract  = {The interplay of albumin (BSA) and lysozyme (LYZ) adsorbed simultaneously on titanium was analyzed by gel electrophoresis and BCA assay. It was found that BSA and lysozyme adsorb cooperatively. Additionally, the isoelectric point of the respective protein influences the adsorption. Also, the enzymatic activity of lysozyme and amylase (AMY) in mixtures with BSA was considered with respect to a possible influence of protein-protein interaction on enzyme activity. Indeed, an increase of lysozyme activity in the presence of BSA could be observed. In contrast, BSA does not influence the activity of amylase.},
  language  = {en}
}
@inproceedings{RuppKuperjansSchulze2016,
  author    = {Rupp, Matthias and Kuperjans, Isabel and Schulze, Sven},
  title     = {Energetische und {\"o}kologische Bewertung hybrider Antriebe im st{\"a}dtischen Busverkehr},
  series = {Commercial vehicle technology 2016 : proceedings of the 4th Commercial Vehicle Technology Symposium (CVT 2016), March 8-10, 2016, University of Kaiserslautern, Kaiserslautern, Germany},
  booktitle = {Commercial vehicle technology 2016 : proceedings of the 4th Commercial Vehicle Technology Symposium (CVT 2016), March 8-10, 2016, University of Kaiserslautern, Kaiserslautern, Germany},
  editor    = {Berns, Karsten},
  publisher = {Shaker},
  address   = {Aachen},
  organization    = {Internationales Commercial Vehicle Technology Symposium <4, 2016, Kaiserslautern>},
  pages     = {227 -- 237},
  year      = {2016},
  abstract  = {In Anbetracht weltweit zunehmend strengerer klimapolitischer Ziele steigt auch der Druck f{\"u}r Nutzfahrzeughersteller, effizientere und umweltfreundlichere Technologien zu entwickeln. Den Blick bei der Bewertung dieser ausschließlich auf die Fahrzeugnutzung zu richten, ist l{\"a}ngst nicht mehr zufriedenstellend. Im Rahmen dieser Analyse wird ein gegenw{\"a}rtig auf dem Markt erwerblicher und in deutschen St{\"a}dten bereits seit Jahren betriebener Hybridbus energetisch und {\"o}kologisch mit einem konventionell angetriebenen, nahezu baugleichen Modell entlang des Lebensweges bewertet. Nach Definition von Ziel und Untersuchungsrahmen wird ein {\"U}berblick auf bereits durchgef{\"u}hrte Lebenszyklusanalysen zu Hybridbussen im Stadtverkehr gegeben und Schlussfolgerungen f{\"u}r die anschließende Analyse abgeleitet. Diese wird im Rahmen einer energetischen und {\"o}kologischen Bewertung beider Produktsysteme anhand der Parameter "Prim{\"a}renergieeinsatz" und "CO2{\"a}q Emissionen" praktiziert. Der Fahrzeugrumpf beider Fahrzeuge des gleichen Modells wird dabei als einheitlich angenommen, sodass bei dem Vergleich der Herstellung vereinfacht nur die sich unterscheidenden Komponenten des Antriebstranges ber{\"u}cksichtigt werden. Die Resultate der Wirkungsabsch{\"a}tzung werden als Differenz des Hybridbusses gegen{\"u}ber dem Referenzfahrzeug {\"u}ber die einzelnen Lebenszyklusphasen dargestellt. Schließlich werden Prognosen getroffen, ab welcher Strecke die bei der Herstellung erzeugten h{\"o}heren CO2{\"a}q Emissionen des Hybridantriebstranges gegen{\"u}ber dem Referenzmodell ausgeglichen werden.},
  language  = {de}
}
@article{RothTippkoetter2016,
  author    = {Roth, Jasmine and Tippk{\"o}tter, Nils},
  title     = {Evaluation of lignocellulosic material for butanol production using enzymatic hydrolysate medium},
  series = {Cellulose Chemistry and Technology},
  volume    = {50},
  journal   = {Cellulose Chemistry and Technology},
  number    = {3-4},
  publisher = {Editura Academiei Romane},
  address   = {Bukarest},
  pages     = {405 -- 410},
  year      = {2016},
  abstract  = {Butanol is a promising gasoline additive and platform chemical that can be readily produced via acetone-butanolethanol (ABE) fermentation from pretreated lignocellulosic materials. This article examines lignocellulosic material from beech wood for ABE fermentation, using Clostridium acetobutylicum. First, the utilization of both C₅₋ (xylose) and C₆₋ (glucose) sugars as sole carbon source was investigated in static cultivation, using serum bottles and synthetic medium. The utilization of pentose sugar resulted in a solvent yield of 0.231 g·g_sugar⁻¹, compared to 0.262 g·g_sugar⁻¹ using hexose. Then, the Organosolv pretreated crude cellulose fibers (CF) were enzymatically decomposed, and the resulting hydrolysate medium was analyzed for inhibiting compounds (furans, organic acids, phenolics) and treated with ionexchangers for detoxification. Batch fermentation in a bioreactor using CF hydrolysate medium resulted in a total solvent yield of 0.20 gABE·g_sugar⁻¹.},
  language  = {en}
}
@misc{RothTippkoetter2016,
  author    = {Roth, J. and Tippk{\"o}tter, Nils},
  title     = {New Approach for Enzymatic Hydrolysis of Lignocellulose with Selective Diffusion Separation of the Monosaccharide Products},
  series = {Chemie Ingenieur Technik},
  volume    = {88},
  journal   = {Chemie Ingenieur Technik},
  number    = {9},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {0009-286X},
  doi       = {10.1002/cite.201650301},
  pages     = {1237},
  year      = {2016},
  abstract  = {Enzymatic hydrolysis of lignocellulosic material plays an important role in the classical biorefinery approach. Apart from the pretreatment of the raw material, hydrolysis is the basis for the conversion of the cellulose and hemicellulose fraction into fermentable sugars. After hydrolysis, usually a solid-liquid separation takes place, in order to separate the residual plant material from the sugar-rich fraction, which can be subsequently used in a fermentation step. In order to factor out the separation step, the usage of in alginate immobilized crude cellulose fiber beads (CFBs) were evaluated. Pretreated cellulose fibers are incorporated in an alginate matrix together with the relevant enzymes. In doing so, sugars diffuse trough the alginate matrix, allowing a simplified delivery into the surrounding fluid. This again reduces product inhibition of the glucose on the enzyme catalysts. By means of standardized bead production the hydrolysis in lab scale was possible. First results show that liberation of glucose and xylose is possible, allowing a maximum total sugar yield of 75 \%.},
  language  = {en}
}
@inproceedings{RothMoehringTippkoetter2016,
  author    = {Roth, J. and M{\"o}hring, S. and Tippk{\"o}tter, Nils},
  title     = {Characterization and evaluation of lignocellulosic biomass 130 hydrolysates for ABE fermentation},
  series = {New frontiers of biotech-processes (Himmelfahrtstagung) : 02-04 May 2016, Rhein-Mosel-Halle, Koblenz/Germany},
  booktitle = {New frontiers of biotech-processes (Himmelfahrtstagung) : 02-04 May 2016, Rhein-Mosel-Halle, Koblenz/Germany},
  publisher = {DECHEMA},
  address   = {Frankfurt am Main},
  pages     = {130},
  year      = {2016},
  language  = {en}
}
@article{RosinButenwegKlinkel2016,
  author    = {Rosin, Julia and Butenweg, Christoph and Klinkel, Sven},
  title     = {Stabilit{\"a}tsnachweis f{\"u}r seismisch beanspruchte Tankbauwerke nach dem LBA/MNA-Konzept},
  series = {Bauingenieur},
  volume    = {91},
  journal   = {Bauingenieur},
  number    = {12},
  publisher = {VDI Fachmedien},
  address   = {D{\"u}sseldorf},
  issn      = {0005-6650},
  doi       = {10.37544/0005-6650-2016-12-74},
  pages     = {518 -- 526},
  year      = {2016},
  abstract  = {Eine seismische Anregung verursacht in einem Fl{\"u}ssigkeitstank einen kombinierten Spannungszustand, was zu einem Stabilit{\"a}tsversagen der h{\"a}ufig sehr d{\"u}nnwandigen Konstruktionen f{\"u}hren kann. F{\"u}r die Durchf{\"u}hrung von Stabilit{\"a}tsnachweisen stehen verschiedene Verfahren zur Verf{\"u}gung. {\"U}blicherweise werden aus Gr{\"u}nden der Einfachheit spannungsbasierte Verfahren angewendet. Diese sind f{\"u}r Einheitslastf{\"a}lle experimentell abgesichert, wobei eine {\"U}bertragung auf kombinierte Spannungszust{\"a}nde wie im Erdbebenfall nur begrenzt m{\"o}glich ist. Alternativ kann ein globales, numerisches Konzept, das LBA/MNA-Verfahren, angewendet werden. Das Verfahren kombiniert eine materiell nichtlineare Berechnung (MNA) mit einer linearen Beulanalyse (LBA) und erfasst die Interaktion verschiedener gleichzeitig auftretender Beanspruchungen implizit im Nachweis. Dieser Beitrag demonstriert die Anwendung der Verfahren am Beispiel verschiedener Tankgeometrien mit H{\"o}he/Radius-Verh{\"a}ltnissen zwischen 1 ≤ H/R ≤ 2 und Radius/Tankwand-Verh{\"a}ltnissen zwischen 500 ≤ R/t ≤ 1000 und diskutiert zus{\"a}tzlich die Defizite der spannungsbasierten Nachweisverfahren.},
  language  = {de}
}
@article{RieperGebhardtStucker2016,
  author    = {Rieper, Harald and Gebhardt, Andreas and Stucker, Brent},
  title     = {Selective Laser Melting of the Eutectic Silver-Copper Alloy Ag 28 wt \% Cu},
  series = {RTejournal - Forum f{\"u}r Rapid Technologie},
  volume    = {13},
  journal   = {RTejournal - Forum f{\"u}r Rapid Technologie},
  issn      = {1614-0923},
  url       = {http://nbn-resolving.de/nbn:de:0009-2-44141},
  year      = {2016},
  abstract  = {The aim of this work was to perform a detailed investigation of the use of Selective Laser Melting (SLM) technology to process eutectic silver-copper alloy Ag 28 wt. \% Cu (also called AgCu28). The processing occurred with a Realizer SLM 50 desktop machine. The powder analysis (SEM-topography, EDX, particle distribution) was reported as well as the absorption rates for the near-infrared (NIR) spectrum. Microscope imaging showed the surface topography of the manufactured parts. Furthermore, microsections were conducted for the analysis of porosity. The Design of Experiments approach used the response surface method in order to model the statistical relationship between laser power, spot distance and pulse time.},
  language  = {en}
}
@inproceedings{RieperGebhardtStucker2016,
  author    = {Rieper, Harald and Gebhardt, Andreas and Stucker, Brent},
  title     = {Process parameters for Selective Laser Melting of AgCu7},
  series = {DDMC, Fraunhofer Direct Digital Manufacturing Conference, 3},
  booktitle = {DDMC, Fraunhofer Direct Digital Manufacturing Conference, 3},
  publisher = {Fraunhofer-Verlag},
  address   = {Stuttgart},
  isbn      = {978-3-8396-1001-5},
  pages     = {171 -- 176},
  year      = {2016},
  language  = {en}
}
@article{RegerDoeringKuhnhenne2016,
  author    = {Reger, V. and D{\"o}ring, Bernd and Kuhnhenne, M.},
  title     = {Passive und aktive Maßnahmen zur Fl{\"a}chenk{\"u}hlung im Stahl(leicht)bau},
  series = {Bauingenieur},
  volume    = {91},
  journal   = {Bauingenieur},
  number    = {Jul/Aug},
  publisher = {VDI Fachmedien},
  address   = {D{\"u}sseldorf},
  issn      = {0005-6650},
  doi       = {10.37544/0005-6650-2016-07-08-63},
  pages     = {309 -- 316},
  year      = {2016},
  abstract  = {Mit steigenden D{\"a}mmstandards und h{\"o}heren Komfortanforderungen der Nutzer ger{\"a}t die Problematik der sommerlichen {\"U}berhitzung zunehmend in den Fokus. Um die {\"U}berhitzung m{\"o}glichst gering zu halten, sind Maßnahmen und L{\"o}sungen zu entwickeln, die den potenziellen K{\"u}hlbedarf eines Geb{\"a}udes vermeiden sowie reduzieren. Im Rahmen des europ{\"a}ischen Forschungsprojektes BATIMASS wurden Techniken untersucht, die die sommerliche Raumtemperatur ohne zus{\"a}tzliche K{\"u}hlung (passiv) oder aber mit energieeffizienter wasserbasierter Fl{\"a}chenk{\"u}hlung (aktiv) reduzieren und die besonders f{\"u}r Geb{\"a}ude in Stahl(leicht)bauweise geeignet sind. Daf{\"u}r wurde die Methodik der thermisch {\"a}quivalenten Decke weiterentwickelt, um das thermische Verhalten von Profilblechdecken in Geb{\"a}uden f{\"u}r beide L{\"o}sungsans{\"a}tze analysieren zu k{\"o}nnen. Dar{\"u}ber hinaus wurde der Einsatz von Phasenwechselmaterial (PCM) zur Steigerung der Speicherf{\"a}higkeit von leichten Decken mit besonders geringer thermischer Masse in Simulationen sowie im Labor untersucht und bewertet.},
  language  = {de}
}
@inproceedings{RauschLeiseEdereretal.2016,
  author    = {Rausch, Lea and Leise, Philipp and Ederer, Thorsten and Altherr, Lena and Pelz, Peter F.},
  title     = {A comparison of MILP and MINLP solver performance on the example of a drinking water supply system design problem},
  series = {ECCOMAS Congress 2016 VII European Congress on Computational Methods in Applied Sciences and Engineering},
  booktitle = {ECCOMAS Congress 2016 VII European Congress on Computational Methods in Applied Sciences and Engineering},
  editor    = {Papadrakakis, M. and Ppadopoulos, V. and Stefanou, G. and Plevris, V.},
  isbn      = {978-618-82844-0-1},
  pages     = {8509 -- 8527},
  year      = {2016},
  abstract  = {Finding a good system topology with more than a handful of components is a highly non-trivial task. The system needs to be able to fulfil all expected load cases, but at the same time the components should interact in an energy-efficient way. An example for a system design problem is the layout of the drinking water supply of a residential building. It may be reasonable to choose a design of spatially distributed pumps which are connected by pipes in at least two dimensions. This leads to a large variety of possible system topologies. To solve such problems in a reasonable time frame, the nonlinear technical characteristics must be modelled as simple as possible, while still achieving a sufficiently good representation of reality. The aim of this paper is to compare the speed and reliability of a selection of leading mathematical programming solvers on a set of varying model formulations. This gives us empirical evidence on what combinations of model formulations and solver packages are the means of choice with the current state of the art.},
  language  = {en}
}
@inproceedings{RajanHoltschoppenDalgueretal.2016,
  author    = {Rajan, Sreelakshmy and Holtschoppen, B. and Dalguer, L. A. and Klinkel, S. and Butenweg, Christoph},
  title     = {Seismic fragility analysis of a non-conventional reinforced concrete structure considering different uncertainties},
  series = {Proceedings of ISMA2016, International Conference on Noise and Vibration Engineering/USD2016, International Conference on Uncertainty in Structural Dynamics, / ISMA 2016, USD 2016},
  booktitle = {Proceedings of ISMA2016, International Conference on Noise and Vibration Engineering/USD2016, International Conference on Uncertainty in Structural Dynamics, / ISMA 2016, USD 2016},
  editor    = {Sas, P.},
  publisher = {KU Leuven},
  address   = {Leuven},
  pages     = {4213 -- 4225},
  year      = {2016},
  language  = {en}
}
@article{PookhalilAmoabedinyTabeshetal.2016,
  author    = {Pookhalil, Ali and Amoabediny, Ghassem and Tabesh, Hadi and Behbahani, Mehdi and Mottaghy, Khosrow},
  title     = {A new approach for semiempirical modeling of mechanical blood trauma},
  series = {The international journal of artificial organs},
  volume    = {39},
  journal   = {The international journal of artificial organs},
  number    = {4},
  publisher = {Sage},
  address   = {London},
  issn      = {1724-6040},
  doi       = {10.5301/ijao.5000474},
  pages     = {171 -- 177},
  year      = {2016},
  abstract  = {Purpose Two semi-empirical models were recently published, both making use of existing literature data, but each taking into account different physical phenomena that trigger hemolysis. In the first model, hemoglobin (Hb) release is described as a permeation procedure across the membrane, assuming a shear stress-dependent process (sublethal model). The second model only accounts for hemoglobin release that is caused by cell membrane breakdown, which occurs when red blood cells (RBC) undergo mechanically induced shearing for a period longer than the threshold time (nonuniform threshold model). In this paper, we introduce a model that considers the hemolysis generated by both these possible phenomena. Methods Since hemolysis can possibly be caused by permeation of hemoglobin through the RBC functional membrane as well as by release of hemoglobin from RBC membrane breakdown, our proposed model combines both these models. An experimental setup consisting of a Couette device was utilized for validation of our proposed model. Results A comparison is presented between the damage index (DI) predicted by the proposed model vs. the sublethal model vs. the nonthreshold model and experimental datasets. This comparison covers a wide range of shear stress for both human and porcine blood. An appropriate agreement between the measured DI and the DI predicted by the present model was obtained. Conclusions The semiempirical hemolysis model introduced in this paper aims for significantly enhanced conformity with experimental data. Two phenomenological outcomes become possible with the proposed approach: an estimation of the average time after which cell membrane breakdown occurs under the applied conditions, and a prediction of the ratio between the phenomena involved in hemolysis.},
  language  = {en}
}
@inproceedings{PoghossianBronderSchejaetal.2016,
  author    = {Poghossian, Arshak and Bronder, Thomas and Scheja, S. and Wu, Chunsheng and Metzger-Boddien, C. and Keusgen, M. and Sch{\"o}ning, Michael Josef},
  title     = {Label-free Electrostatic Detection of DNA Amplification by PCR Using Capacitive Field-effect Devices},
  series = {Procedia Engineering},
  volume    = {Vol. 168},
  booktitle = {Procedia Engineering},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1877-7058},
  doi       = {10.1016/j.proeng.2016.11.512},
  pages     = {514 -- 517},
  year      = {2016},
  abstract  = {A capacitive field-effect EIS (electrolyte-insulator-semiconductor) sensor modified with a positively charged weak polyelectrolyte of poly(allylamine hydrochloride) (PAH)/single-stranded probe DNA (ssDNA) bilayer has been used for a label-free electrostatic detection of pathogen-specific DNA amplification via polymerase chain reaction (PCR). The sensor is able to distinguish between positive and negative PCR solutions, to detect the existence of target DNA amplicons in PCR samples and thus, can be used as tool for a quick verification of DNA amplification and the successful PCR process.},
  language  = {en}
}
@article{PinkenburgSchiffelsSelmer2016,
  author    = {Pinkenburg, Olaf and Schiffels, Johannes and Selmer, Thorsten},
  title     = {Das CoLibry-Konzept - ein Werkzeugkasten f{\"u}r die Synthetische Biologie: Bioproduktion},
  series = {BIOspektrum},
  volume    = {22},
  journal   = {BIOspektrum},
  number    = {6},
  publisher = {Springer},
  address   = {Berlin},
  doi       = {10.1007/s12268-016-0734-8},
  pages     = {593 -- 595},
  year      = {2016},
  abstract  = {Regardless of size or destination, synthetic biology starts with com-parably small information units, which need to be combined and properly arranged in order to achieve a certain goal. This may be the de novo synthesis of individual genes from oligonucleotides, a shuffling of protein domains in order to create novel biocatalysts, the assembly of multiple enzyme encoding genes in metabolic pathway design, or strain development at the production stage. The CoLibry concept has been designed in order to close the gap between recombinant production of individual genes and genome editing.},
  language  = {de}
}