@article{DemirciKurulganDemirciTrzewiketal.2009,
  author    = {Demirci, Taylan and Kurulgan Demirci, Eylem and Trzewik, J{\"u}rgen and Linder, Peter and Digel, Ilya and Artmann, Gerhard and Sakizli, Meral and Temiz Artmann, Ayseg{\"u}l},
  title     = {Gene expression profile analysis of 3T3/NIH fibroblasts after one hour mechanical stress},
  series = {IUBMB Life. 61 (2009), H. 3},
  journal   = {IUBMB Life. 61 (2009), H. 3},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  isbn      = {1521-6543},
  pages     = {311 -- 312},
  year      = {2009},
  language  = {en}
}
@article{KurulganDemirciDemirciTrzewiketal.2011,
  author    = {Kurulgan Demirci, Eylem and Demirci, T. and Trzewik, J{\"u}rgen and Linder, Peter and Karakulah, G. and Artmann, Gerhard and Sakizli, M. and Temiz Artmann, Ayseg{\"u}l},
  title     = {Genome-Wide Gene Expression Analysis of NIH 3T3 Cell Line Under Mechanical Stimulation},
  series = {Cellular and molecular bioengineering. 4 (2011), H. 1},
  journal   = {Cellular and molecular bioengineering. 4 (2011), H. 1},
  publisher = {Springer},
  address   = {Berlin},
  isbn      = {1865-5025},
  pages     = {46 -- 55},
  year      = {2011},
  language  = {en}
}
@incollection{DuongSeifarthTemizArtmannetal.2018,
  author    = {Duong, Minh Tuan and Seifarth, Volker and Temiz Artmann, Ayseg{\"u}l and Artmann, Gerhard and Staat, Manfred},
  title     = {Growth Modelling Promoting Mechanical Stimulation of Smooth Muscle Cells of Porcine Tubular Organs in a Fibrin-PVDF Scaffold},
  series = {Biological, Physical and Technical Basics of Cell Engineering},
  booktitle = {Biological, Physical and Technical Basics of Cell Engineering},
  editor    = {Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l and Zhubanova, Azhar A. and Digel, Ilya},
  publisher = {Springer},
  address   = {Singapore},
  isbn      = {978-981-10-7904-7},
  doi       = {10.1007/978-981-10-7904-7_9},
  pages     = {209 -- 232},
  year      = {2018},
  abstract  = {Reconstructive surgery and tissue replacements like ureters or bladders reconstruction have been recently studied, taking into account growth and remodelling of cells since living cells are capable of growing, adapting, remodelling or degrading and restoring in order to deform and respond to stimuli. Hence, shapes of ureters or bladders and their microstructure change during growth and these changes strongly depend on external stimuli such as training. We present the mechanical stimulation of smooth muscle cells in a tubular fibrin-PVDFA scaffold and the modelling of the growth of tissue by stimuli. To this end, mechanotransduction was performed with a kyphoplasty balloon catheter that was guided through the lumen of the tubular structure. The bursting pressure was examined to compare the stability of the incubated tissue constructs. The results showed the significant changes on tissues with training by increasing the burst pressure as a characteristic mechanical property and the smooth muscle cells were more oriented with uniformly higher density. Besides, the computational growth models also exhibited the accurate tendencies of growth of the cells under different external stimuli. Such models may lead to design standards for the better layered tissue structure in reconstructing of tubular organs characterized as composite materials such as intestines, ureters and arteries.},
  language  = {en}
}
@article{StadlerDigelArtmannetal.2008,
  author    = {Stadler, A. M. and Digel, Ilya and Artmann, Gerhard and Embs, Jan P. and Zaccai, Joe and B{\"u}ldt, Georg},
  title     = {Hemoglobin Dynamics in Red Blood Cells: Correlation to Body Temperature},
  series = {Biophysical Journal. 95 (2008), H. 11},
  journal   = {Biophysical Journal. 95 (2008), H. 11},
  isbn      = {1542-0086},
  pages     = {5449 -- 5461},
  year      = {2008},
  language  = {en}
}
@article{ArtmannZerlinDigel2008,
  author    = {Artmann, Gerhard and Zerlin, Kay and Digel, Ilya},
  title     = {Hemoglobin Senses Body Temperature},
  series = {Bioengineering in Cell and Tissue Research / Artmann, Gerhard M. ; Chien, Shu (Eds.)},
  journal   = {Bioengineering in Cell and Tissue Research / Artmann, Gerhard M. ; Chien, Shu (Eds.)},
  publisher = {Springer},
  address   = {Berlin},
  isbn      = {978-3-540-75408-4},
  pages     = {415 -- 447},
  year      = {2008},
  language  = {en}
}
@article{ArtmannDigelZerlinetal.2009,
  author    = {Artmann, Gerhard and Digel, Ilya and Zerlin, Kay and Maggakis-Kelemen, Christina and Linder, Peter and Porst, Dariusz and Kayser, Peter and Stadler, David and Dikta, Gerhard and Temiz Artmann, Ayseg{\"u}l},
  title     = {Hemoglobin senses body temperature},
  series = {European Biophysics Journal},
  volume    = {38},
  journal   = {European Biophysics Journal},
  number    = {5},
  isbn      = {0175-7571},
  pages     = {589 -- 600},
  year      = {2009},
  language  = {en}
}
@article{LinderDigelTemizArtmannetal.2007,
  author    = {Linder, Peter and Digel, Ilya and Temiz Artmann, Ayseg{\"u}l and Kayser, Peter and Porst, Dariusz and Artmann, Gerhard},
  title     = {High-throughput testing of mechanical forces generated in thin cell and tissue layers},
  series = {Tissue Engineering. 13 (2007), H. 7},
  journal   = {Tissue Engineering. 13 (2007), H. 7},
  isbn      = {1076-3279},
  pages     = {1778 -- 1778},
  year      = {2007},
  language  = {en}
}
@techreport{Artmann2011,
  author    = {Artmann, Gerhard},
  title     = {HPBioforce: Integrierte und automatisierte Screening Plattform eines 96-Well-Hochdurchsatz-Testsystems zur funktionellen Kraftmessung an einige um dicken Zell- und Gewebeschichten f{\"u}r die Arzneimittelforschung : gemeinsamer Abschlussbericht der FH Aachen, Hitec Zang GmbH, IKFE Mainz, IKFE Berlin und der Dr. Gerhard Schmidt GmbH zum InnoNet-Projekt ... ; Programm "F{\"o}rderung von innovativen Netzwerken" (InnoNet) des Bundesministerium f{\"u}r Wirtschaft und Technologie (BMWi) ; Laufzeit: 01.05.2007 bis 31.12.2010},
  publisher = {Technische Informationsbibliothek u. Universit{\"a}tsbibliothek},
  address   = {Aachen [u.a.]},
  doi       = {10.2314/GBV:68757076X},
  year      = {2011},
  language  = {de}
}
@article{ArtmannZhouStacheBuettneretal.2002,
  author    = {Artmann, Gerhard and Zhou-Stache, J. and Buettner, R. and Mittermayer, C. [u.a.]},
  title     = {Inhibition of TNF-alpha induced cell death in HUVEC and Jurkat cells by protocatechuic acid. Zhou-Stache, J.; Buettner, R.; Artmann, Gerhard Michael; Mittermayer, C.; Bosserhoff, A. K.},
  series = {Medical and Biological Engineering and Computing. 40 (2002), H. 6},
  journal   = {Medical and Biological Engineering and Computing. 40 (2002), H. 6},
  isbn      = {0140-0118},
  pages     = {698 -- 703},
  year      = {2002},
  language  = {en}
}
@article{EijckDemmelArtmannetal.2011,
  author    = {Eijck, Lambert van and Demmel, Franz and Artmann, Gerhard and Stadtler, Andreas Maximilian},
  title     = {Macromolecular dynamics in red blood cells investigated using neutron spectroscopy},
  series = {Journal of the Royal Society Interface},
  volume    = {8},
  journal   = {Journal of the Royal Society Interface},
  number    = {57},
  publisher = {The Royal Society},
  address   = {London},
  isbn      = {1742-5689},
  pages     = {590 -- 600},
  year      = {2011},
  language  = {en}
}
@article{SeifarthGrosseGrossmannetal.2017,
  author    = {Seifarth, Volker and Grosse, Joachim O. and Grossmann, Matthias and Janke, Heinz Peter and Arndt, Patrick and Koch, Sabine and Epple, Matthias and Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l},
  title     = {Mechanical induction of bi-directional orientation of primary porcine bladder smooth muscle cells in tubular fibrin-poly(vinylidene fluoride) scaffolds for ureteral and urethral repair using cyclic and focal balloon catheter stimulation},
  series = {Journal of Biomaterials Applications},
  volume    = {32},
  journal   = {Journal of Biomaterials Applications},
  number    = {3},
  publisher = {Sage},
  address   = {London},
  issn      = {1530-8022},
  doi       = {10.1177/0885328217723178},
  pages     = {321 -- 330},
  year      = {2017},
  language  = {en}
}
@article{DemirciTrzewikLinderetal.2004,
  author    = {Demirci, T. and Trzewik, J. and Linder, Peter and Digel, Ilya and Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l},
  title     = {Mechanical Stimulation of 3T3 Fibroblasts Activates Genes: ITGB5 and p53 Responses as Quantified on the mRNA Level},
  series = {Biomedizinische Technik . 49 (2004), H. Erg.-Bd. 2},
  journal   = {Biomedizinische Technik . 49 (2004), H. Erg.-Bd. 2},
  isbn      = {0932-4666},
  pages     = {1030 -- 1031},
  year      = {2004},
  language  = {en}
}
@article{DemirciTrzewikLinderetal.2004,
  author    = {Demirci, T. and Trzewik, J. and Linder, Peter and Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l},
  title     = {Mechanical Stimulation of 3T3 Fibroblasts Activates Genes: Real Time PCR Products and Suppliers by Comparison},
  series = {Biomedizinische Technik . 49 (2004), H. Erg.-Bd. 2},
  journal   = {Biomedizinische Technik . 49 (2004), H. Erg.-Bd. 2},
  isbn      = {0932-4666},
  pages     = {1046 -- 1047},
  year      = {2004},
  language  = {en}
}
@article{ArtmannDigelLinderetal.2008,
  author    = {Artmann, Gerhard and Digel, Ilya and Linder, Peter and Porst, Dariusz},
  title     = {Mechanism of haemoglobin sensing body temperature},
  series = {Tissue Engineering Part A. 14 (2008), H. 5},
  journal   = {Tissue Engineering Part A. 14 (2008), H. 5},
  isbn      = {1937-3341},
  pages     = {754 -- 754},
  year      = {2008},
  language  = {en}
}
@article{GossmannFrotscherLinderetal.2016,
  author    = {Goßmann, Matthias and Frotscher, Ralf and Linder, Peter and Bayer, Robin and Epple, U. and Staat, Manfred and Temiz Artmann, Ayseg{\"u}l and Artmann, Gerhard},
  title     = {Mechano-pharmacological characterization of cardiomyocytes derived from human induced pluripotent stem cells},
  series = {Cellular physiology and biochemistry},
  volume    = {38},
  journal   = {Cellular physiology and biochemistry},
  number    = {3},
  publisher = {Karger},
  address   = {Basel},
  issn      = {1421-9778 (Online)},
  doi       = {10.1159/000443124},
  pages     = {1182 -- 1198},
  year      = {2016},
  abstract  = {Background/Aims: Common systems for the quantification of cellular contraction rely on animal-based models, complex experimental setups or indirect approaches. The herein presented CellDrum technology for testing mechanical tension of cellular monolayers and thin tissue constructs has the potential to scale-up mechanical testing towards medium-throughput analyses. Using hiPS-Cardiac Myocytes (hiPS-CMs) it represents a new perspective of drug testing and brings us closer to personalized drug medication. Methods: In the present study, monolayers of self-beating hiPS-CMs were grown on ultra-thin circular silicone membranes and deflect under the weight of the culture medium. Rhythmic contractions of the hiPS-CMs induced variations of the membrane deflection. The recorded contraction-relaxation-cycles were analyzed with respect to their amplitudes, durations, time integrals and frequencies. Besides unstimulated force and tensile stress, we investigated the effects of agonists and antagonists acting on Ca²⁺ channels (S-Bay K8644/verapamil) and Na⁺ channels (veratridine/lidocaine). Results: The measured data and simulations for pharmacologically unstimulated contraction resembled findings in native human heart tissue, while the pharmacological dose-response curves were highly accurate and consistent with reference data. Conclusion: We conclude that the combination of the CellDrum with hiPS-CMs offers a fast, facile and precise system for pharmacological, toxicological studies and offers new preclinical basic research potential.},
  language  = {en}
}
@article{BayerTemizArtmannDigeletal.2020,
  author    = {Bayer, Robin and Temiz Artmann, Ayseg{\"u}l and Digel, Ilya and Falkenstein, Julia and Artmann, Gerhard and Creutz, Till and Hescheler, J{\"u}rgen},
  title     = {Mechano-pharmacological testing of L-Type Ca²⁺ channel modulators via human vascular celldrum model},
  series = {Cellular Physiology and Biochemistry},
  volume    = {54},
  journal   = {Cellular Physiology and Biochemistry},
  publisher = {Cell Physiol Biochem Press},
  address   = {D{\"u}sseldorf},
  issn      = {1421-9778},
  doi       = {10.33594/000000225},
  pages     = {371 -- 383},
  year      = {2020},
  abstract  = {Background/Aims: This study aimed to establish a precise and well-defined working model, assessing pharmaceutical effects on vascular smooth muscle cell monolayer in-vitro. It describes various analysis techniques to determine the most suitable to measure the biomechanical impact of vasoactive agents by using CellDrum technology. Methods: The so-called CellDrum technology was applied to analyse the biomechanical properties of confluent human aorta muscle cells (haSMC) in monolayer. The cell generated tensions deviations in the range of a few N/m² are evaluated by the CellDrum technology. This study focuses on the dilative and contractive effects of L-type Ca²⁺ channel agonists and antagonists, respectively. We analyzed the effects of Bay K8644, nifedipine and verapamil. Three different measurement modes were developed and applied to determine the most appropriate analysis technique for the study purpose. These three operation modes are called, particular time mode" (PTM), "long term mode" (LTM) and "real-time mode" (RTM). Results: It was possible to quantify the biomechanical response of haSMCs to the addition of vasoactive agents using CellDrum technology. Due to the supplementation of 100nM Bay K8644, the tension increased approximately 10.6\% from initial tension maximum, whereas, the treatment with nifedipine and verapamil caused a significant decrease in cellular tension: 10nM nifedipine decreased the biomechanical stress around 6,5\% and 50nM verapamil by 2,8\%, compared to the initial tension maximum. Additionally, all tested measurement modes provide similar results while focusing on different analysis parameters. Conclusion: The CellDrum technology allows highly sensitive biomechanical stress measurements of cultured haSMC monolayers. The mechanical stress responses evoked by the application of vasoactive calcium channel modulators were quantified functionally (N/m²). All tested operation modes resulted in equal findings, whereas each mode features operation-related data analysis.},
  language  = {en}
}
@article{BeckerWallangArtmannetal.2008,
  author    = {Becker, C. and Wallang, C. and Artmann, Gerhard and Jakse, G.},
  title     = {Mechanotransduction-bioreactor for tissue engineering of a ureter prosthesis},
  series = {International Journal of Artificial Organs, The},
  volume    = {31},
  journal   = {International Journal of Artificial Organs, The},
  number    = {7},
  issn      = {0391-3988},
  pages     = {583 -- 583},
  year      = {2008},
  language  = {en}
}
@article{DigelKayserArtmann2008,
  author    = {Digel, Ilya and Kayser, Peter and Artmann, Gerhard},
  title     = {Molecular processes in biological thermosensation},
  series = {Journal of Biophysics. 2008 (2008)},
  journal   = {Journal of Biophysics. 2008 (2008)},
  isbn      = {1687-8000},
  pages     = {1 -- 9},
  year      = {2008},
  language  = {en}
}
@article{KowalskiLinderZierkeetal.2016,
  author    = {Kowalski, Julia and Linder, Peter and Zierke, S. and Wulfen, B. van and Clemens, J. and Konstantinidis, K. and Ameres, G. and Hoffmann, R. and Mikucki, J. and Tulaczyk, S. and Funke, O. and Blandfort, D. and Espe, Clemens and Feldmann, Marco and Francke, Gero and Hiecker, S. and Plescher, Engelbert and Sch{\"o}ngarth, Sarah and Dachwald, Bernd and Digel, Ilya and Artmann, Gerhard and Eliseev, D. and Heinen, D. and Scholz, F. and Wiebusch, C. and Macht, S. and Bestmann, U. and Reineking, T. and Zetzsche, C. and Schill, K. and F{\"o}rstner, R. and Niedermeier, H. and Szumski, A. and Eissfeller, B. and Naumann, U. and Helbing, K.},
  title     = {Navigation technology for exploration of glacier ice with maneuverable melting probes},
  series = {Cold Regions Science and Technology},
  journal   = {Cold Regions Science and Technology},
  number    = {123},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0165-232X},
  doi       = {10.1016/j.coldregions.2015.11.006},
  pages     = {53 -- 70},
  year      = {2016},
  abstract  = {The Saturnian moon Enceladus with its extensive water bodies underneath a thick ice sheet cover is a potential candidate for extraterrestrial life. Direct exploration of such extraterrestrial aquatic ecosystems requires advanced access and sampling technologies with a high level of autonomy. A new technological approach has been developed as part of the collaborative research project Enceladus Explorer (EnEx). The concept is based upon a minimally invasive melting probe called the IceMole. The force-regulated, heater-controlled IceMole is able to travel along a curved trajectory as well as upwards. Hence, it allows maneuvers which may be necessary for obstacle avoidance or target selection. Maneuverability, however, necessitates a sophisticated on-board navigation system capable of autonomous operations. The development of such a navigational system has been the focal part of the EnEx project. The original IceMole has been further developed to include relative positioning based on in-ice attitude determination, acoustic positioning, ultrasonic obstacle and target detection integrated through a high-level sensor fusion. This paper describes the EnEx technology and discusses implications for an actual extraterrestrial mission concept.},
  language  = {en}
}
@article{MiciliValterOflazetal.2013,
  author    = {Micili, Serap C. and Valter, Markus and Oflaz, Hakan and Ozogul, Candan and Linder, Peter and F{\"o}ckler, Nicole and Artmann, Gerhard and Digel, Ilya and Temiz Artmann, Ayseg{\"u}l},
  title     = {Optical coherence tomography : a potential tool to predict premature rupture of fetal membranes},
  series = {Proceedings of the Institution of Mechanical Engineers. Part H : Journal of engineering in medicine},
  volume    = {Vol. 227},
  journal   = {Proceedings of the Institution of Mechanical Engineers. Part H : Journal of engineering in medicine},
  number    = {No. 4},
  publisher = {Sage},
  address   = {London},
  issn      = {0046-2039 (Print) ; 2041-3033 (E-Journal)},
  pages     = {393 -- 401},
  year      = {2013},
  language  = {en}
}