@article{Olbertz2020,
  author    = {Olbertz, Klaus},
  title     = {Wenn der „leitende" Angestellte doch nur ein „normaler" Arbeitnehmer ist ... : Zur Rechtsstellung leitender Angestellter, zu Fehleinsch{\"a}tzungen des Arbeitgebers und Praxishinweisen},
  series = {NWB - Steuer- und Wirtschaftsrecht},
  journal   = {NWB - Steuer- und Wirtschaftsrecht},
  number    = {32},
  publisher = {NWB-Verl.},
  address   = {Herne},
  issn      = {0028-3460},
  pages     = {2397 -- 2406},
  year      = {2020},
  language  = {de}
}
@book{Timme2020,
  author    = {Timme, Michael},
  title     = {WEG - Wohnungeigentumsgesetz / Hrsg. von Michael Timme . Stand 01.02.2020 ; Edition: 40},
  publisher = {Beck},
  address   = {M{\"u}nchen},
  year      = {2020},
  language  = {de}
}
@book{Timme2020,
  author    = {Timme, Michael},
  title     = {WEG - Wohnungeigentumsgesetz / Hrsg. von Michael Timme . Stand: 01.05.2020 ; Edition 41},
  publisher = {Beck},
  address   = {M{\"u}nchen},
  year      = {2020},
  language  = {de}
}
@inproceedings{MeckMuellerAltherretal.2020,
  author    = {Meck, Marvin M. and M{\"u}ller, Tim M. and Altherr, Lena and Pelz, Peter F.},
  title     = {Improving an industrial cooling system using MINLP, considering capital and operating costs},
  series = {Operations Research Proceedings 2019},
  booktitle = {Operations Research Proceedings 2019},
  publisher = {Springer},
  address   = {Cham},
  isbn      = {978-3-030-48438-5 (Print)},
  doi       = {10.1007/978-3-030-48439-2_61},
  pages     = {505 -- 512},
  year      = {2020},
  abstract  = {The chemical industry is one of the most important industrial sectors in Germany in terms of manufacturing revenue. While thermodynamic boundary conditions often restrict the scope for reducing the energy consumption of core processes, secondary processes such as cooling offer scope for energy optimisation. In this contribution, we therefore model and optimise an existing cooling system. The technical boundary conditions of the model are provided by the operators, the German chemical company BASF SE. In order to systematically evaluate different degrees of freedom in topology and operation, we formulate and solve a Mixed-Integer Nonlinear Program (MINLP), and compare our optimisation results with the existing system.},
  language  = {en}
}
@article{MuellerLeiseLorenzetal.2020,
  author    = {M{\"u}ller, Tim M. and Leise, Philipp and Lorenz, Imke-Sophie and Altherr, Lena and Pelz, Peter F.},
  title     = {Optimization and validation of pumping system design and operation for water supply in high-rise buildings},
  series = {Optimization and Engineering},
  volume    = {2021},
  journal   = {Optimization and Engineering},
  number    = {22},
  publisher = {Springer},
  issn      = {1573-2924},
  doi       = {10.1007/s11081-020-09553-4},
  pages     = {643 -- 686},
  year      = {2020},
  abstract  = {The application of mathematical optimization methods for water supply system design and operation provides the capacity to increase the energy efficiency and to lower the investment costs considerably. We present a system approach for the optimal design and operation of pumping systems in real-world high-rise buildings that is based on the usage of mixed-integer nonlinear and mixed-integer linear modeling approaches. In addition, we consider different booster station topologies, i.e. parallel and series-parallel central booster stations as well as decentral booster stations. To confirm the validity of the underlying optimization models with real-world system behavior, we additionally present validation results based on experiments conducted on a modularly constructed pumping test rig. Within the models we consider layout and control decisions for different load scenarios, leading to a Deterministic Equivalent of a two-stage stochastic optimization program. We use a piecewise linearization as well as a piecewise relaxation of the pumps' characteristics to derive mixed-integer linear models. Besides the solution with off-the-shelf solvers, we present a problem specific exact solving algorithm to improve the computation time. Focusing on the efficient exploration of the solution space, we divide the problem into smaller subproblems, which partly can be cut off in the solution process. Furthermore, we discuss the performance and applicability of the solution approaches for real buildings and analyze the technical aspects of the solutions from an engineer's point of view, keeping in mind the economically important trade-off between investment and operation costs.},
  language  = {en}
}
@inproceedings{MuellerAltherrLeiseetal.2020,
  author    = {M{\"u}ller, Tim M. and Altherr, Lena and Leise, Philipp and Pelz, Peter F.},
  title     = {Optimization of pumping systems for buildings: Experimental validation of different degrees of model detail on a modular test rig},
  series = {Operations Research Proceedings 2019},
  booktitle = {Operations Research Proceedings 2019},
  publisher = {Springer},
  address   = {Cham},
  isbn      = {978-3-030-48438-5},
  doi       = {10.1007/978-3-030-48439-2_58},
  pages     = {481 -- 488},
  year      = {2020},
  abstract  = {Successful optimization requires an appropriate model of the system under consideration. When selecting a suitable level of detail, one has to consider solution quality as well as the computational and implementation effort. In this paper, we present a MINLP for a pumping system for the drinking water supply of high-rise buildings. We investigate the influence of the granularity of the underlying physical models on the solution quality. Therefore, we model the system with a varying level of detail regarding the friction losses, and conduct an experimental validation of our model on a modular test rig. Furthermore, we investigate the computational effort and show that it can be reduced by the integration of domain-specific knowledge.},
  language  = {en}
}
@article{EckertAbbasiMangetal.2020,
  author    = {Eckert, Alexander and Abbasi, Mozhdeh and Mang, Thomas and Saalw{\"a}chter, Kay and Walther, Andreas},
  title     = {Structure, Mechanical Properties, and Dynamics of Polyethylenoxide/Nanoclay Nacre-Mimetic Nanocomposites},
  series = {Macromolecules},
  volume    = {53},
  journal   = {Macromolecules},
  number    = {5},
  publisher = {ACS Publications},
  address   = {Washington, DC},
  issn      = {1520-5835},
  doi       = {10.1021/acs.macromol.9b01931},
  pages     = {1716 -- 1725},
  year      = {2020},
  abstract  = {Nacre-mimetic nanocomposites based on high fractions of synthetic high-aspect-ratio nanoclays in combination with polymers are continuously pushing boundaries for advanced material properties, such as high barrier against oxygen, extraordinary mechanical behavior, fire shielding, and glass-like transparency. Additionally, they provide interesting model systems to study polymers under nanoconfinement due to the well-defined layered nanocomposite arrangement. Although the general behavior in terms of forming such layered nanocomposite materials using evaporative self-assembly and controlling the nanoclay gallery spacing by the nanoclay/polymer ratio is understood, some combinations of polymer matrices and nanoclay reinforcement do not comply with the established models. Here, we demonstrate a thorough characterization and analysis of such an unusual polymer/nanoclay pair that falls outside of the general behavior. Poly(ethylene oxide) (PEO) and sodium fluorohectorite form nacre-mimetic, lamellar nanocomposites that are completely transparent and show high mechanical stiffness and high gas barrier, but there is only limited expansion of the nanoclay gallery spacing when adding increasing amounts of polymer. This behavior is maintained for molecular weights of PEO varied over four orders of magnitude and can be traced back to depletion forces. By careful investigation via X-ray diffraction and proton low-resolution solid-state NMR, we are able to quantify the amount of mobile and immobilized polymer species in between the nanoclay galleries and around proposed tactoid stacks embedded in a PEO matrix. We further elucidate the unusual confined polymer dynamics, indicating a relevant role of specific surface interactions.},
  language  = {en}
}
@incollection{EngemannDuKallweitetal.2020,
  author    = {Engemann, Heiko and Du, Shengzhi and Kallweit, Stephan and Ning, Chuanfang and Anwar, Saqib},
  title     = {AutoSynPose: Automatic Generation of Synthetic Datasets for 6D Object Pose Estimation},
  series = {Machine Learning and Artificial Intelligence. Proceedings of MLIS 2020},
  booktitle = {Machine Learning and Artificial Intelligence. Proceedings of MLIS 2020},
  publisher = {IOS Press},
  address   = {Amsterdam},
  isbn      = {978-1-64368-137-5},
  doi       = {10.3233/FAIA200770},
  pages     = {89 -- 97},
  year      = {2020},
  abstract  = {We present an automated pipeline for the generation of synthetic datasets for six-dimension (6D) object pose estimation. Therefore, a completely automated generation process based on predefined settings is developed, which enables the user to create large datasets with a minimum of interaction and which is feasible for applications with a high object variance. The pipeline is based on the Unreal 4 (UE4) game engine and provides a high variation for domain randomization, such as object appearance, ambient lighting, camera-object transformation and distractor density. In addition to the object pose and bounding box, the metadata includes all randomization parameters, which enables further studies on randomization parameter tuning. The developed workflow is adaptable to other 3D objects and UE4 environments. An exemplary dataset is provided including five objects of the Yale-CMU-Berkeley (YCB) object set. The datasets consist of 6 million subsegments using 97 rendering locations in 12 different UE4 environments. Each dataset subsegment includes one RGB image, one depth image and one class segmentation image at pixel-level.},
  language  = {en}
}
@article{EngemannDuKallweitetal.2020,
  author    = {Engemann, Heiko and Du, Shengzhi and Kallweit, Stephan and C{\"o}nen, Patrick and Dawar, Harshal},
  title     = {OMNIVIL - an autonomous mobile manipulator for flexible production},
  series = {Sensors},
  volume    = {20},
  journal   = {Sensors},
  number    = {24, art. no. 7249},
  publisher = {MDPI},
  address   = {Basel},
  isbn      = {1424-8220},
  doi       = {10.3390/s20247249},
  pages     = {1 -- 30},
  year      = {2020},
  language  = {en}
}
@inproceedings{HoegenDonckerRuetters2020,
  author    = {Hoegen, Anne von and Doncker, Rik W. De and R{\"u}tters, Ren{\´e}},
  title     = {Teaching Digital Control of Operational Amplifier Processes with a LabVIEW Interface and Embedded Hardware},
  series = {2020 23rd International Conference on Electrical Machines and Systems (ICEMS)},
  booktitle = {2020 23rd International Conference on Electrical Machines and Systems (ICEMS)},
  publisher = {IEEE},
  address   = {New York, NY},
  doi       = {10.23919/ICEMS50442.2020.9290928},
  pages     = {1117 -- 1122},
  year      = {2020},
  abstract  = {Control engineering theory is hard to grasp for undergraduates during the first semesters, as it deals with the dynamical behavior of systems also in combination with control strategies on an abstract level. Therefore, operational amplifier (OpAmp) processes are reasonable and very effective systems to connect mathematical description with actual system's behavior. In this paper, we present an experiment for a laboratory session in which an embedded system, driven by a LabVIEW human machine interface (HMI) via USB, controls the analog circuits.With this setup we want to show the possibility of firstly, analyzing a first order process and secondly, designing a P-and PI-controller. Thereby, the theory of control engineering is always applied to the empirical results in order to break down the abstract level for the students.},
  language  = {en}
}
@inproceedings{UlmerBraunChengetal.2020,
  author    = {Ulmer, Jessica and Braun, Sebastian and Cheng, Chi-Tsun and Dowey, Steve and Wollert, J{\"o}rg},
  title     = {Gamified Virtual Reality Training Environment for the Manufacturing Industry},
  series = {Proceedings of the 2020 19th International Conference on Mechatronics - Mechatronika (ME)},
  booktitle = {Proceedings of the 2020 19th International Conference on Mechatronics - Mechatronika (ME)},
  publisher = {IEEE},
  address   = {New York, NY},
  doi       = {10.1109/ME49197.2020.9286661},
  pages     = {1 -- 6},
  year      = {2020},
  abstract  = {Industry 4.0 imposes many challenges for manufacturing companies and their employees. Innovative and effective training strategies are required to cope with fast-changing production environments and new manufacturing technologies. Virtual Reality (VR) offers new ways of on-the-job, on-demand, and off-premise training. A novel concept and evaluation system combining Gamification and VR practice for flexible assembly tasks is proposed in this paper and compared to existing works. It is based on directed acyclic graphs and a leveling system. The concept enables a learning speed which is adjustable to the users' pace and dynamics, while the evaluation system facilitates adaptive work sequences and allows employee-specific task fulfillment. The concept was implemented and analyzed in the Industry 4.0 model factory at FH Aachen for mechanical assembly jobs.},
  language  = {de}
}
@article{MoratFaudeHanssenetal.2020,
  author    = {Morat, Mareike and Faude, Oliver and Hanssen, Henner and Ludyga, Sebastian and Zacher, Jonas and Eibl, Angi and Albracht, Kirsten and Donath, Lars},
  title     = {Agility Training to Integratively Promote Neuromuscular, Cognitive, Cardiovascular and Psychosocial Function in Healthy Older Adults: A Study Protocol of a One-Year Randomized-Controlled Trial},
  series = {International Journal of Environmental Research and Public Health},
  volume    = {17},
  journal   = {International Journal of Environmental Research and Public Health},
  number    = {6},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {1660-4601},
  doi       = {10.3390/ijerph17061853},
  pages     = {1 -- 14},
  year      = {2020},
  abstract  = {Exercise training effectively mitigates aging-induced health and fitness impairments. Traditional training recommendations for the elderly focus separately on relevant physiological fitness domains, such as balance, flexibility, strength and endurance. Thus, a more holistic and functional training framework is needed. The proposed agility training concept integratively tackles spatial orientation, stop and go, balance and strength. The presented protocol aims at introducing a two-armed, one-year randomized controlled trial, evaluating the effects of this concept on neuromuscular, cardiovascular, cognitive and psychosocial health outcomes in healthy older adults. Eighty-five participants were enrolled in this ongoing trial. Seventy-nine participants completed baseline testing and were block-randomized to the agility training group or the inactive control group. All participants undergo pre- and post-testing with interim assessment after six months. The intervention group currently receives supervised, group-based agility training twice a week over one year, with progressively demanding perceptual, cognitive and physical exercises. Knee extension strength, reactive balance, dual task gait speed and the Agility Challenge for the Elderly (ACE) serve as primary endpoints and neuromuscular, cognitive, cardiovascular, and psychosocial meassures serve as surrogate secondary outcomes. Our protocol promotes a comprehensive exercise training concept for older adults, that might facilitate stakeholders in health and exercise to stimulate relevant health outcomes without relying on excessively time-consuming physical activity recommendations.},
  language  = {en}
}
@article{KetelhutBrueggeGoelletal.2020,
  author    = {Ketelhut, Maike and Br{\"u}gge, G. M. and G{\"o}ll, Fabian and Braunstein, Bjoern and Albracht, Kirsten and Abel, Dirk},
  title     = {Adaptive iterative learning control of an industrial robot during neuromuscular training},
  series = {IFAC PapersOnLine},
  volume    = {53},
  journal   = {IFAC PapersOnLine},
  number    = {2},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {2405-8963},
  doi       = {10.1016/j.ifacol.2020.12.741},
  pages     = {16468 -- 16475},
  year      = {2020},
  abstract  = {To prevent the reduction of muscle mass and loss of strength coming along with the human aging process, regular training with e.g. a leg press is suitable. However, the risk of training-induced injuries requires the continuous monitoring and controlling of the forces applied to the musculoskeletal system as well as the velocity along the motion trajectory and the range of motion. In this paper, an adaptive norm-optimal iterative learning control algorithm to minimize the knee joint loadings during the leg extension training with an industrial robot is proposed. The response of the algorithm is tested in simulation for patients with varus, normal and valgus alignment of the knee and compared to the results of a higher-order iterative learning control algorithm, a robust iterative learning control and a recently proposed conventional norm-optimal iterative learning control algorithm. Although significant improvements in performance are made compared to the conventional norm-optimal iterative learning control algorithm with a small learning factor, for the developed approach as well as the robust iterative learning control algorithm small steady state errors occur.},
  language  = {en}
}
@misc{SchulzeBuxlohGrossCheng2020,
  author    = {Schulze-Buxloh, Lina and Groß, Rolf Fritz and Cheng, Kevin Toni},
  title     = {Development and manufacturing of an interactive three-dimensional phase diagram of carbon dioxide for teaching sessions in thermodynamics},
  series = {Proceedings of the International Conference The Future of Education 2020},
  journal   = {Proceedings of the International Conference The Future of Education 2020},
  year      = {2020},
  language  = {en}
}
@inproceedings{BedburMoorkampPetersonetal.2020,
  author    = {Bedbur, Christian and Moorkamp, Wilfried and Peterson, Leif Arne and Uibel, Thomas},
  title     = {Holzbr{\"u}cken mit Natursteinbel{\"a}gen - Untersuchungen zur Aktivierung der Verbundwirkung},
  series = {Doktorandenkolloquium Holzbau Forschung + Praxis 2020},
  booktitle = {Doktorandenkolloquium Holzbau Forschung + Praxis 2020},
  editor    = {Kuhlmann, Ulrike},
  publisher = {Universit{\"a}t Stuttgart, Institut f{\"u}r Konstruktion und Entwurf},
  address   = {Stuttgart},
  pages     = {53 -- 60},
  year      = {2020},
  language  = {de}
}
@inproceedings{IomdinaKiselevaKotliaretal.2020,
  author    = {Iomdina, Elena N. and Kiseleva, Anna A. and Kotliar, Konstantin and Luzhnov, Petr V.},
  title     = {Quantification of Choroidal Blood Flow Using the OCT-A System Based on Voxel Scan Processing},
  series = {Proceedings of the International Conference on Biomedical Innovations and Applications- BIA 2020},
  booktitle = {Proceedings of the International Conference on Biomedical Innovations and Applications- BIA 2020},
  publisher = {IEEE},
  address   = {New York, NY},
  isbn      = {978-1-7281-7073-2},
  doi       = {10.1109/BIA50171.2020.9244511},
  pages     = {41 -- 44},
  year      = {2020},
  abstract  = {The paper presents a method for the quantitative assessment of choroidal blood flow using an OCT-A system. The developed technique for processing of OCT-A scans is divided into two stages. At the first stage, the identification of the boundaries in the selected portion was performed. At the second stage, each pixel mark on the selected layer was represented as a volume unit, a voxel, which characterizes the region of moving blood. Three geometric shapes were considered to represent the voxel. On the example of one OCT-A scan, this work presents a quantitative assessment of the blood flow index. A possible modification of two-stage algorithm based on voxel scan processing is presented.},
  language  = {en}
}
@article{MalanHamerKaeneletal.2020,
  author    = {Malan, Leone and Hamer, Mark and K{\"a}nel, Roland von and Kotliar, Konstantin and Wyk, Roelof D. van and Lambert, Gavin W. and Vilser, Walthard and Ziemssen, Tjalf and Schlaich, Markus P. and Smith, Wayne and Magnusson, Martin and Wentzel, Annemarie and Myburgh, Carlien E. and Steyn, Hendrik S. and Malan, Nico T.},
  title     = {Delayed retinal vein recovery responses indicate both non-adaptation to stress as well as increased risk for stroke: the SABPA study},
  series = {Cardiovascular Journal of Africa},
  volume    = {26},
  journal   = {Cardiovascular Journal of Africa},
  number    = {31},
  publisher = {Clinics Cardive Publishing},
  address   = {Durbanville},
  issn      = {1680-0745},
  doi       = {10.5830/CVJA-2020-031},
  pages     = {1 -- 12},
  year      = {2020},
  language  = {en}
}
@article{StreeseKotliarDeiserothetal.2020,
  author    = {Streese, Lukas and Kotliar, Konstantin and Deiseroth, Arne and Infanger, Denis and Gugleta, Konstantin and Schmaderer, Christoph and Hanssen, Henner},
  title     = {Retinal endothelial function in cardiovascular risk patients: A randomized controlled exercise trial},
  series = {Scandinavian Journal of Medicine and Science in Sports},
  volume    = {30},
  journal   = {Scandinavian Journal of Medicine and Science in Sports},
  number    = {2},
  publisher = {Wiley},
  address   = {Oxford},
  issn      = {1600-0838},
  doi       = {10.1111/sms.13560},
  pages     = {272 -- 280},
  year      = {2020},
  abstract  = {The aim of this study was to investigate, for the first time, the effects of high-intensity interval training (HIIT) on retinal microvascular endothelial function in cardiovascular (CV) risk patients. In the randomized controlled trial, middle-aged and previously sedentary patients with increased CV risk (aged 58 ± 6 years) with ≥ two CV risk factors were randomized into a 12-week HIIT (n = 33) or control group (CG, n = 36) with standard physical activity recommendations. A blinded examiner measured retinal endothelial function by flicker light-induced maximal arteriolar (ADmax) and venular (VDmax) dilatation as well as the area under the arteriolar (AFarea) and venular (VFarea) flicker curve using a retinal vessel analyzer. Standardized assessments of CV risk factors, cardiorespiratory fitness, and retinal endothelial function were performed before and after HIIT. HIIT reduced body mass index, fat mass, and low-density lipoprotein and increased muscle mass and peak oxygen uptake (VO2peak). Both ADmax (pre: 2.7 ± 2.1\%, post: 3.0 ± 2.2\%, P = .018) and AFarea (pre: 32.6 ± 28.4\%*s, post: 37.7 ± 30.6\%*s, P = .016) increased after HIIT compared with CG (ADmax, pre: 3.2 ± 1.8\%, post: 2.9 ± 1.8\%, P = .254; AFarea, pre: 41.6 ± 28.5\%*s, post: 37.8 ± 27.0\%*s, P = .186). Venular function remained unchanged after HIIT. There was a significant association between ∆-change VO2peak and ∆-changes ADmax and AFarea (P = .026, R² = 0.073; P = .019, R² = 0.081, respectively). 12-weeks of HIIT improved retinal endothelial function in middle-aged patients with increased CV risk independent of the reduction in classical CV risk factors. Exercise has the potential to reverse or at least postpone progression of small vessel disease in older adults with increased CV risk under standard medication. Dynamic retinal vessel analysis seems to be a sensitive tool to detect treatment effects of exercise interventions on retinal microvascular endothelial function in middle-aged individuals with increased CV risk.},
  language  = {en}
}
@article{HamouKotliarTanetal.2020,
  author    = {Hamou, Hussam Aldin and Kotliar, Konstantin and Tan, Sonny Kian and Weiß, Christel and Blume, Christian and Clusmann, Hans and Schubert, Gerrit Alexander and Albanna, Walid},
  title     = {Surgical nuances and placement of subgaleal drains for supratentorial procedures—a prospective analysis of efficacy and outcome in 150 craniotomies},
  series = {Acta Neurochirurgica},
  volume    = {2020},
  journal   = {Acta Neurochirurgica},
  number    = {162},
  publisher = {Springer Nature},
  address   = {Cham},
  issn      = {0942-0940},
  doi       = {10.1007/s00701-019-04196-6},
  pages     = {729 -- 736},
  year      = {2020},
  abstract  = {Background For supratentorial craniotomy, surgical access, and closure technique, including placement of subgaleal drains, may vary considerably. The influence of surgical nuances on postoperative complications such as cerebrospinal fluid leakage or impaired wound healing overall remains largely unclear. With this study, we are reporting our experiences and the impact of our clinical routines on outcome in a prospectively collected data set. Method We prospectively observed 150 consecutive patients undergoing supratentorial craniotomy and recorded technical variables (type/length of incision, size of craniotomy, technique of dural and skin closure, type of dressing, and placement of subgaleal drains). Outcome variables (subgaleal hematoma/CSF collection, periorbital edema, impairment of wound healing, infection, and need for operative revision) were recorded at time of discharge and at late follow-up. Results Early subgaleal fluid collection was observed in 36.7\% (2.8\% at the late follow-up), and impaired wound healing was recorded in 3.3\% of all cases, with an overall need for operative revision of 6.7\%. Neither usage of dural sealants, lack of watertight dural closure, and presence of subgaleal drains, nor type of skin closure or dressing influenced outcome. Curved incisions, larger craniotomy, and tumor size, however, were associated with an increase in early CSF or hematoma collection (p < 0.0001, p = 0.001, p < 0.01 resp.), and larger craniotomy size was associated with longer persistence of subgaleal fluid collections (p < 0.05). Conclusions Based on our setting, individual surgical nuances such as the type of dural closure and the use of subgaleal drains resulted in a comparable complication rate and outcome. Subgaleal fluid collections were frequently observed after supratentorial procedures, irrespective of the closing technique employed, and resolve spontaneously in the majority of cases without significant sequelae. Our results are limited due to the observational nature in our single-center study and need to be validated by supportive prospective randomized design.},
  language  = {en}
}
@article{RamoshabaHuismanLammertynetal.2020,
  author    = {Ramoshaba, Nthai E. and Huisman, Hugo W. and Lammertyn, Leandi and Kotliar, Konstantin and Schutte, Aletta E. and Smith, Wayne},
  title     = {Retinal microvasculature and masked hypertension in young adults: the African-PREDICT study},
  series = {Hypertension Research},
  journal   = {Hypertension Research},
  number    = {43},
  publisher = {Springer Nature},
  address   = {Osaka},
  issn      = {1348-4214},
  doi       = {10.1038/s41440-020-0487-0},
  pages     = {1231 -- 1238},
  year      = {2020},
  abstract  = {Masked hypertension is known to induce microvascular complications. However, it is unclear whether early microvascular changes are already occurring in young, otherwise healthy adults. We therefore investigated whether retinal microvascular calibers and acute responses to a flicker stimulus are related to masked hypertension. We used the baseline data of 889 participants aged 20-30 years who were taking part in the African Prospective study on the Early Detection and Identification of Cardiovascular Disease and Hypertension. Clinic and 24-h ambulatory blood pressure were measured. The central retinal artery equivalent (CRAE) and central retinal vein equivalent were calculated from fundus images, and retinal vessel dilation was determined in response to flicker light-induced provocation. A smaller CRAE was observed in those with masked hypertension vs. those with normotension (157.1 vs. 161.2 measuring units, P < 0.001). In forward multivariable-adjusted regression analysis, only CRAE was negatively related to masked hypertension [adjusted R² = 0.267, β = -0.097 (95\% CI = -0.165; -0.029), P = 0.005], but other retinal microvascular parameters were not associated with masked hypertension. In multivariable logistic regression analyses, masked hypertension [OR = 2.333, (95\% CI = 1.316; 4.241), P = 0.004] was associated with a narrower CRAE. In young healthy adults, masked hypertension was associated with retinal arteriolar narrowing, thereby reflecting early microvascular alterations known to predict cardiovascular outcomes in later life.},
  language  = {en}
}