@masterthesis{Voth2022,
  type      = {Bachelor Thesis},
  author    = {Voth, Emily},
  title     = {KiWA : Die Garderobe f{\"u}r kleine Selbstst{\"a}ndige},
  publisher = {FH Aachen},
  address   = {Aachen},
  pages     = {117 Seiten},
  year      = {2022},
  abstract  = {Kindertagesst{\"a}tten bieten Kleinkindern den Zugang zu unbeschwertem und spielerischem Lernen. Was also, wenn schon der Eingangsbereich die Reiz{\"u}berflutung bereit h{\"a}lt, der Stauraum der Entfaltung der Kinder nicht gerecht wird und ihre Eigenst{\"a}ndigkeit ungef{\"o}rdert bleibt? Es kommt zu unzufriedenen Kindern und Frustration aller Beteilligten. "KIWA" ist das Garderobensystem f{\"u}r Kinder zur St{\"a}rkung der heranwachsenden Selbstst{\"a}ndigkeit. Mithilfe von pers{\"o}nlichen Wiedererkennungsmerkmalen wird Eigenverantwortung geschult. Leicht und sicher zu erreichender Stauraum sorgt f{\"u}r Ordnung. Spielerisches lernen trotz Ordnung.},
  language  = {de}
}
@article{MonakhovaDiehl2022,
  author    = {Monakhova, Yulia and Diehl, Bernd W.K.},
  title     = {Multinuclear NMR screening of pharmaceuticals using standardization by 2H integral of a deuterated solvent},
  series = {Journal of Pharmaceutical and Biomedical Analysis},
  volume    = {209},
  journal   = {Journal of Pharmaceutical and Biomedical Analysis},
  number    = {Article number: 114530},
  publisher = {Elsevier},
  isbn      = {0731-7085},
  doi       = {10.1016/j.jpba.2021.114530},
  year      = {2022},
  abstract  = {NMR standardization approach that uses the 2H integral of deuterated solvent for quantitative multinuclear analysis of pharmaceuticals is described. As a proof of principle, the existing NMR procedure for the analysis of heparin products according to US Pharmacopeia monograph is extended to the determination of Na+ and Cl- content in this matrix. Quantification is performed based on the ratio of a 23Na (35Cl) NMR integral and 2H NMR signal of deuterated solvent, D2O, acquired using the specific spectrometer hardware. As an alternative, the possibility of 133Cs standardization using the addition of Cs2CO3 stock solution is shown. Validation characteristics (linearity, repeatability, sensitivity) are evaluated. A holistic NMR profiling of heparin products can now also be used for the quantitative determination of inorganic compounds in a single analytical run using a single sample. In general, the new standardization methodology provides an appealing alternative for the NMR screening of inorganic and organic components in pharmaceutical products.},
  language  = {en}
}
@article{EngelmannPourshahidiShalabyetal.2022,
  author    = {Engelmann, Ulrich M. and Pourshahidi, Mohammad Ali and Shalaby, Ahmed and Krause, Hans-Joachim},
  title     = {Probing particle size dependency of frequency mixing magnetic detection with dynamic relaxation simulation},
  series = {Journal of Magnetism and Magnetic Materials},
  volume    = {563},
  journal   = {Journal of Magnetism and Magnetic Materials},
  number    = {In progress, Art. No. 169965},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0304-8853},
  doi       = {10.1016/j.jmmm.2022.169965},
  year      = {2022},
  abstract  = {Biomedical applications of magnetic nanoparticles (MNP) fundamentally rely on the particles' magnetic relaxation as a response to an alternating magnetic field. The magnetic relaxation complexly depends on the interplay of MNP magnetic and physical properties with the applied field parameters. It is commonly accepted that particle core size is a major contributor to signal generation in all the above applications, however, most MNP samples comprise broad distribution spanning nm and more. Therefore, precise knowledge of the exact contribution of individual core sizes to signal generation is desired for optimal MNP design generally for each application. Specifically, we present a magnetic relaxation simulation-driven analysis of experimental frequency mixing magnetic detection (FMMD) for biosensing to quantify the contributions of individual core size fractions towards signal generation. Applying our method to two different experimental MNP systems, we found the most dominant contributions from approx. 20 nm sized particles in the two independent MNP systems. Additional comparison between freely suspended and immobilized MNP also reveals insight in the MNP microstructure, allowing to use FMMD for MNP characterization, as well as to further fine-tune its applicability in biosensing.},
  language  = {en}
}
@misc{Buechel2022,
  type      = {Master Thesis},
  author    = {B{\"u}chel, Carolin},
  title     = {GYMLET : dein mobiles Freiluftstudio - Entwicklung eines serientauglichen Prototypen und einer Vermarktungsstrategie},
  publisher = {FH Aachen},
  address   = {Aachen},
  pages     = {93 Seiten},
  year      = {2022},
  abstract  = {Sportvereine verlieren zunehmend Mitglieder. Grund daf{\"u}r ist der wachsende Wunsch nach unabh{\"a}ngigen Trainingsm{\"o}glichkeiten. GYMLET bietet den Sportler:innen die M{\"o}glichkeit, ihre Fitness funktional, selbstorganisiert und unabh{\"a}ngig zu trainieren. Dabei kann durch den selbstbestimmten Trainingsort neben der k{\"o}rperlichen Fitness vor allem die Motivation zur sportlichen Aktivit{\"a}t und das Wohlbefinden gesteigert werden. Unterst{\"u}tzt wird das Trainingssystem durch eine App, welche den Sportler:innen neben Nutzungsm{\"o}glichkeiten als Coach und Trainingsplaner dient. Um diese Trainingsm{\"o}glichkeit an die Zielgruppe heranzutragen, ist eine Kampagnenstrategie aus zwei Phasen entstanden. In dieser sollen Postings und Clips {\"u}ber Instagram und Youtube ver{\"o}ffentlicht werden. Zus{\"a}tzlich werden Zeitschriften und m{\"o}gliche Kooperationen mit Therapeuten oder Freizeitunterk{\"u}nften zur Ver{\"o}ffentlichung der Kampagne genutzt.},
  language  = {de}
}
@masterthesis{Frank2022,
  type      = {Bachelor Thesis},
  author    = {Frank, Jemima Leonie},
  title     = {Falling in love with the female gaze},
  publisher = {FH Aachen},
  address   = {Aachen},
  school      = {Fachhochschule Aachen},
  pages     = {81 Seiten},
  year      = {2022},
  abstract  = {Der „Male Gaze" bezeichnet das typische Erleben der Umwelt aus m{\"a}nnlicher Perspektive und pr{\"a}gt in den sogenannten Mainstream-Medien die Gestaltung von Film, Fernsehen und Werbung. Dadurch werden von dargestellten Personen h{\"a}ufig die k{\"o}rperlichen Aspekte hervorgehoben. Im Gegensatz dazu gilt das weibliche Pendant, der „Female Gaze", als besonders emotionsbetont. Weil Medien einen enormen Einfluss auf gesellschaftliches und individuelles Denken haben, stellt die Dominanz des „Male Gaze" eine Unausgeglichenheit dar, die sich in verschiedenen Bereichen des gesellschaftlichen Lebens widerspiegelt. Deswegen m{\"o}chte dieses Projekt die Medien um die weibliche Sichtweise erweitern und damit die dort transportierten Bilder diverser und ausgewogener machen. Die Fotografie fokussiert sich dabei auf die Gef{\"u}hlswelt der Protagonistin, womit die Betrachter:Innen schrittweise in ihre Position hineinversetzt werden sollen. Mit Augen des Mitgef{\"u}hls und eigenem Sch{\"o}nheitsbegriff l{\"a}sst „Falling in love with the female gaze" endlich auch die Frau zu Wort kommen.},
  language  = {de}
}
@misc{Rouenhoff2022,
  type      = {Master Thesis},
  author    = {Rouenhoff, Saskia},
  title     = {Blind - invisible connection : ein Spiel zur kritischen Auseinandersetzung mit den sozialen Medien.},
  publisher = {FH Aachen},
  address   = {Aachen},
  pages     = {321 Seiten},
  year      = {2022},
  abstract  = {Im Computerspiel „blind - invisible connection" taucht der Spieler in eine Fantasiewelt ein, die die sozialen Medien widerspiegelt und von einer Maschine beherrscht wird. Um zu erfahren, was in dieser Welt geschehen ist, muss die Geschichte Schritt f{\"u}r Schritt erspielt und wie ein Puzzle zusammengesetzt werden. Dabei interagieren die Spieler:innen mittels Dialogen mit den Bewohner:innen der Fantasiewelt und l{\"o}sen R{\"a}tsel, die die Geschichte enth{\"u}llen. Durch Analogien zwischen der Fantasiewelt und den sozialen Medien wird die Funktionsweise und der Einfluss der Plattformen auf die Menschen und die Gesellschaft verdeutlicht. So wird eine Reflexion des eigenen Umgangs mit den sozialen Medien angeregt und Gespr{\"a}chsstoff f{\"u}r Diskussionen unter den Spieler:innen und Mitmenschen geliefert.},
  language  = {de}
}
@masterthesis{Kocaoglu2022,
  type      = {Bachelor Thesis},
  author    = {Kocaoglu, Berna},
  title     = {System zur Unterst{\"u}tzung von Blinden im Alltag},
  publisher = {FH Aachen},
  address   = {Aachen},
  pages     = {45 Seiten},
  year      = {2022},
  abstract  = {Unterhaltungsgegenst{\"a}nde und ihre Add-Ons stellen f{\"u}r viele Menschen ein wichtiger Bestandteil eines ausgewogenen Lebens dar und sind somit nicht mehr aus klassischen Haushalten wegzudenken. Doch nicht jeder Menschen hat {\"u}berhaupt Zugang zu ihnen, weil die Systeme meistens auf Durchschnittsb{\"u}rger:Innen abgestimmt sind. Davon betroffen sind beispielsweise Menschen mit Blindheit und Seheinschr{\"a}nkung. Um das Angebot individueller zu gestalten, wurde diesem Projekt ein Home-Entertainment-System entwickelt, das eben genau auf die Bed{\"u}rfnisse dieser Gruppe zugeschnitten ist. F{\"u}r die bedienungsfreundliche Gestaltung wurde im gesamten Prozess besonders viel Wert auf die konkrete Lebensrealit{\"a}t von Blinden und Menschen mit Seheinschr{\"a}nkungen gelegt. Hier sollen m{\"o}gliche Einschr{\"a}nkungen {\"u}berwunden werden und sich m{\"o}glichst den tats{\"a}chlichen Anforderungen in der Praxis anpassen. Dazu musste zun{\"a}chst ein umfassendes Verst{\"a}ndnis des Krankheitsbildes geschult werden. Außerdem wurde ein Blick in den Alltag dieser Menschen geworfen. Welche Home-Entertainmentger{\"a}te finden bereits im Wohnzimmer Platz und welche Komplikationen gibt es mit ihnen? Die breite Palette an Produkten gibt einen Eindruck davon, welche Funktionen ersetzt und welche Systeme gegebenenfalls miteinander verkn{\"u}pft werden k{\"o}nnen. Auf der Basis umfassender Recherche ist eine Fernbedienung entstanden, die sowohl per Sprachsteuerung als auch {\"u}ber physische Steuerung steuerbar ist. Zahlreiche taktile Elemente geben Orientierung bei der Nutzung und gew{\"a}hrleisten ein reibungsloses und handliches Nutzungserlebnis. Die Arbeit {\"o}ffnet den Blick f{\"u}r andere Lebenswelten und pl{\"a}diert f{\"u}r den Abbau von Barrieren f{\"u}r ein selbstbestimmteres Leben.},
  language  = {de}
}
@article{HarrisKleefeld2022,
  author    = {Harris, Isaac and Kleefeld, Andreas},
  title     = {Analysis and computation of the transmission eigenvalues with a conductive boundary condition},
  series = {Applicable Analysis},
  volume    = {101},
  journal   = {Applicable Analysis},
  number    = {6},
  publisher = {Taylor \& Francis},
  address   = {London},
  issn      = {1563-504X},
  doi       = {10.1080/00036811.2020.1789598},
  pages     = {1880 -- 1895},
  year      = {2022},
  abstract  = {We provide a new analytical and computational study of the transmission eigenvalues with a conductive boundary condition. These eigenvalues are derived from the scalar inverse scattering problem for an inhomogeneous material with a conductive boundary condition. The goal is to study how these eigenvalues depend on the material parameters in order to estimate the refractive index. The analytical questions we study are: deriving Faber-Krahn type lower bounds, the discreteness and limiting behavior of the transmission eigenvalues as the conductivity tends to infinity for a sign changing contrast. We also provide a numerical study of a new boundary integral equation for computing the eigenvalues. Lastly, using the limiting behavior we will numerically estimate the refractive index from the eigenvalues provided the conductivity is sufficiently large but unknown.},
  language  = {en}
}
@incollection{MoorkampPetersonUibel2022,
  author    = {Moorkamp, Wilfried and Peterson, Leif Arne and Uibel, Thomas},
  title     = {Nachhaltige Holzbr{\"u}cken f{\"u}r Geh- und Radwege},
  series = {Bauphysik Kalender 2022: Holzbau, 22. Jahrgang},
  booktitle = {Bauphysik Kalender 2022: Holzbau, 22. Jahrgang},
  editor    = {Fouad, Nabil A.},
  publisher = {Ernst \& Sohn},
  address   = {Berlin},
  isbn      = {9783433033609 (Print)},
  doi       = {10.1002/9783433611081.ch17},
  pages     = {574 -- 592},
  year      = {2022},
  abstract  = {Am Lehr- und Forschungsgebiet Holzbau der Fachhochschule Aachen wurden im Rahmen des Forschungsvorhabens „Nachhaltige Standardbr{\"u}cken in Holzbauweise" Standardtypen f{\"u}r Geh- und Radwegbr{\"u}cken entwickelt. Die Br{\"u}cken sind durch konsequente Umsetzungen von Maßnahmen des konstruktiven Holzschutzes f{\"u}r eine Nutzung von mehr als 80~Jahren konzipiert. Innovative L{\"o}sungen f{\"u}r Bauteile und Anschl{\"u}sse sowie Materialalternativen im Bereich des Belages und der Gel{\"a}nder erm{\"o}glichen eine wartungsarme Konstruktion und tragen somit zur Wirtschaftlichkeit und Nachhaltigkeit bei. Um den Einsatz der entwickelten Standardbr{\"u}ckentypen in der Praxis zu erleichtern, wurden Leistungsverzeichnisse, Musterstatiken, Musterzeichnungen und umfangreiche Detailkataloge als Unterst{\"u}tzung f{\"u}r Planer und Bauherren erstellt. Damit die Randbedingungen f{\"u}r eine lange Lebensdauer w{\"a}hrend der Nutzung der Br{\"u}cke erhalten bleiben, wurden Leitf{\"a}den f{\"u}r die Pflege und Wartung sowie f{\"u}r die Br{\"u}ckenpr{\"u}fung erarbeitet. Der Beitrag gibt Einblicke in das Forschungsvorhaben und seine Resultate.},
  language  = {de}
}
@article{FunkeEschRoosen2022,
  author    = {Funke, Harald and Esch, Thomas and Roosen, Petra},
  title     = {Antriebssystemanpassungen zur Verwendung von LPG als Flugkraftstoff},
  series = {Motortechnische Zeitschrift (MTZ)},
  volume    = {2022},
  journal   = {Motortechnische Zeitschrift (MTZ)},
  number    = {83},
  publisher = {Springer Nature},
  address   = {Basel},
  doi       = {10.1007/s35146-021-0778-2},
  pages     = {58 -- 62},
  year      = {2022},
  abstract  = {Auch in der allgemeinen Luftfahrt w{\"a}re es w{\"u}nschenswert, die bereits vorhandenen Verbrennungsmotoren mit weniger CO₂-tr{\"a}chtigen Kraftstoffen als dem heute weit verbreiteten Avgas 100LL betreiben zu k{\"o}nnen. Es ist anzunehmen, dass im Vergleich die unter Normalbedingungen gasf{\"o}rmigen Kraftstoffe CNG, LPG oder LNG deutlich weniger Emissionen produzieren. Erforderliche Antriebssystemanpassungen wurden im Rahmen eines Forschungsprojekts an der FH Aachen untersucht.},
  language  = {de}
}
@article{WeldenPoghossianVahidpouretal.2022,
  author    = {Welden, Melanie and Poghossian, Arshak and Vahidpour, Farnoosh and Wendlandt, Tim and Keusgen, Michael and Wege, Christina and Sch{\"o}ning, Michael Josef},
  title     = {Towards multi-analyte detection with field-effect capacitors modified with tobacco mosaic virus bioparticles as enzyme nanocarriers},
  series = {Biosensors},
  volume    = {12},
  journal   = {Biosensors},
  number    = {1},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2079-6374},
  doi       = {10.3390/bios12010043},
  pages     = {Artikel 43},
  year      = {2022},
  abstract  = {Utilizing an appropriate enzyme immobilization strategy is crucial for designing enzyme-based biosensors. Plant virus-like particles represent ideal nanoscaffolds for an extremely dense and precise immobilization of enzymes, due to their regular shape, high surface-to-volume ratio and high density of surface binding sites. In the present work, tobacco mosaic virus (TMV) particles were applied for the co-immobilization of penicillinase and urease onto the gate surface of a field-effect electrolyte-insulator-semiconductor capacitor (EISCAP) with a p-Si-SiO₂-Ta₂O₅ layer structure for the sequential detection of penicillin and urea. The TMV-assisted bi-enzyme EISCAP biosensor exhibited a high urea and penicillin sensitivity of 54 and 85 mV/dec, respectively, in the concentration range of 0.1-3 mM. For comparison, the characteristics of single-enzyme EISCAP biosensors modified with TMV particles immobilized with either penicillinase or urease were also investigated. The surface morphology of the TMV-modified Ta₂O₅-gate was analyzed by scanning electron microscopy. Additionally, the bi-enzyme EISCAP was applied to mimic an XOR (Exclusive OR) enzyme logic gate.},
  language  = {en}
}
@inproceedings{SchopenShabaniEschetal.2022,
  author    = {Schopen, Oliver and Shabani, Bahman and Esch, Thomas and Kemper, Hans and Shah, Neel},
  title     = {Quantitative evaluation of health management designs for fuel cell systems in transport vehicles},
  series = {2nd UNITED-SAIG International Conference Proceedings},
  booktitle = {2nd UNITED-SAIG International Conference Proceedings},
  editor    = {Rahim, S.A. and As'arry, A. and Zuhri, M.Y.M. and Harmin, M.Y. and Rezali, K.A.M. and Hairuddin, A.A.},
  pages     = {1 -- 3},
  year      = {2022},
  abstract  = {Focusing on transport vehicles, mainly with regard to aviation applications, this paper presents compilation and subsequent quantitative evaluation of methods aimed at building an optimum integrated health management solution for fuel cell systems. The methods are divided into two different main types and compiled in a related scheme. Furthermore, different methods are analysed and evaluated based on parameters specific to the aviation context of this study. Finally, the most suitable method for use in fuel cell health management systems is identified and its performance and suitability is quantified.},
  language  = {en}
}
@article{Finkenberger2022,
  author    = {Finkenberger, Isabel Maria},
  title     = {Strukturwandel als transformative Wende},
  series = {disP: The Planning Review},
  volume    = {58},
  journal   = {disP: The Planning Review},
  number    = {3},
  publisher = {Taylor \& Francis},
  address   = {Abingdon},
  issn      = {0251-3625},
  doi       = {10.1080/02513625.2022.2158603},
  pages     = {86 -- 94},
  year      = {2022},
  language  = {de}
}
@incollection{Fabo2022,
  author    = {Fabo, Sabine},
  title     = {Pl{\"u}schviren - Zur Konstruktion von N{\"a}he in Zeiten der Pandemie},
  series = {Interaktion - Emotion - Desinfektion ; Kunst und Museum in Zeiten von Corona / Birgit Richard, Jana M{\"u}ller, Niklas von Reischach (Hrsg.)},
  booktitle = {Interaktion - Emotion - Desinfektion ; Kunst und Museum in Zeiten von Corona / Birgit Richard, Jana M{\"u}ller, Niklas von Reischach (Hrsg.)},
  publisher = {Campus},
  address   = {Frankfurt ; New York},
  isbn      = {978-3-593-51520-5 (Print)},
  pages     = {45 -- 69},
  year      = {2022},
  language  = {de}
}
@article{KleefeldZimmermann2022,
  author    = {Kleefeld, Andreas and Zimmermann, M.},
  title     = {Computing Elastic Interior Transmission Eigenvalues},
  series = {Integral Methods in Science and Engineering},
  journal   = {Integral Methods in Science and Engineering},
  editor    = {Constanda, Christian and Bodmann, Bardo E.J. and Harris, Paul J.},
  publisher = {Birkh{\"a}user},
  address   = {Cham},
  isbn      = {978-3-031-07171-3},
  doi       = {10.1007/978-3-031-07171-3_10},
  pages     = {139 -- 155},
  year      = {2022},
  abstract  = {An alternative method is presented to numerically compute interior elastic transmission eigenvalues for various domains in two dimensions. This is achieved by discretizing the resulting system of boundary integral equations in combination with a nonlinear eigenvalue solver. Numerical results are given to show that this new approach can provide better results than the finite element method when dealing with general domains.},
  language  = {en}
}
@article{PourshahidiAchtsnichtOffenhaeusseretal.2022,
  author    = {Pourshahidi, Ali Mohammad and Achtsnicht, Stefan and Offenh{\"a}usser, Andreas and Krause, Hans-Joachim},
  title     = {Frequency Mixing Magnetic Detection Setup Employing Permanent Ring Magnets as a Static Offset Field Source},
  series = {Sensors},
  volume    = {22},
  journal   = {Sensors},
  number    = {22},
  editor    = {Offenh{\"a}usser, Andreas},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {1424-8220},
  doi       = {10.3390/s22228776},
  pages     = {12 Seiten},
  year      = {2022},
  abstract  = {Frequency mixing magnetic detection (FMMD) has been explored for its applications in fields of magnetic biosensing, multiplex detection of magnetic nanoparticles (MNP) and the determination of core size distribution of MNP samples. Such applications rely on the application of a static offset magnetic field, which is generated traditionally with an electromagnet. Such a setup requires a current source, as well as passive or active cooling strategies, which directly sets a limitation based on the portability aspect that is desired for point of care (POC) monitoring applications. In this work, a measurement head is introduced that involves the utilization of two ring-shaped permanent magnets to generate a static offset magnetic field. A steel cylinder in the ring bores homogenizes the field. By variation of the distance between the ring magnets and of the thickness of the steel cylinder, the magnitude of the magnetic field at the sample position can be adjusted. Furthermore, the measurement setup is compared to the electromagnet offset module based on measured signals and temperature behavior.},
  language  = {en}
}
@book{Laack2022,
  author    = {Laack, Walter van},
  title     = {Schnittstelle Tod: Was lernen wir durch Corona {\"u}ber Leben und Tod?},
  publisher = {van Laack GmbH},
  address   = {Aachen},
  isbn      = {978-3-936624-53-3},
  pages     = {108 Seiten},
  year      = {2022},
  language  = {de}
}
@article{FalkenbergBottBongaertsetal.2022,
  author    = {Falkenberg, Fabian and Bott, Michael and Bongaerts, Johannes and Siegert, Petra},
  title     = {Phylogenetic survey of the subtilase family and a data-mining-based search for new subtilisins from Bacillaceae},
  series = {Frontiers in Microbiology},
  volume    = {2022},
  journal   = {Frontiers in Microbiology},
  number    = {13},
  publisher = {Frontiers},
  address   = {Lausanne},
  issn      = {1664-302X},
  doi       = {10.3389/fmicb.2022.1017978},
  pages     = {Artikel 13:1017978},
  year      = {2022},
  abstract  = {The subtilase family (S8), a member of the clan SB of serine proteases are ubiquitous in all kingdoms of life and fulfil different physiological functions. Subtilases are divided in several groups and especially subtilisins are of interest as they are used in various industrial sectors. Therefore, we searched for new subtilisin sequences of the family Bacillaceae using a data mining approach. The obtained 1,400 sequences were phylogenetically classified in the context of the subtilase family. This required an updated comprehensive overview of the different groups within this family. To fill this gap, we conducted a phylogenetic survey of the S8 family with characterised holotypes derived from the MEROPS database. The analysis revealed the presence of eight previously uncharacterised groups and 13 subgroups within the S8 family. The sequences that emerged from the data mining with the set filter parameters were mainly assigned to the subtilisin subgroups of true subtilisins, high-alkaline subtilisins, and phylogenetically intermediate subtilisins and represent an excellent source for new subtilisin candidates.},
  language  = {en}
}
@article{WeldenSeverinsPoghossianetal.2022,
  author    = {Welden, Melanie and Severins, Robin and Poghossian, Arshak and Wege, Christina and Bongaerts, Johannes and Siegert, Petra and Keusgen, Michael and Sch{\"o}ning, Michael Josef},
  title     = {Detection of acetoin and diacetyl by a tobacco mosaic virus-assisted field-effect biosensor},
  series = {Chemosensors},
  volume    = {10},
  journal   = {Chemosensors},
  number    = {6},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2227-9040},
  doi       = {10.3390/chemosensors10060218},
  pages     = {Artikel 218},
  year      = {2022},
  abstract  = {Acetoin and diacetyl have a major impact on the flavor of alcoholic beverages such as wine or beer. Therefore, their measurement is important during the fermentation process. Until now, gas chromatographic techniques have typically been applied; however, these require expensive laboratory equipment and trained staff, and do not allow for online monitoring. In this work, a capacitive electrolyte-insulator-semiconductor sensor modified with tobacco mosaic virus (TMV) particles as enzyme nanocarriers for the detection of acetoin and diacetyl is presented. The enzyme acetoin reductase from Alkalihalobacillus clausii DSM 8716ᵀ is immobilized via biotin-streptavidin affinity, binding to the surface of the TMV particles. The TMV-assisted biosensor is electrochemically characterized by means of leakage-current, capacitance-voltage, and constant capacitance measurements. In this paper, the novel biosensor is studied regarding its sensitivity and long-term stability in buffer solution. Moreover, the TMV-assisted capacitive field-effect sensor is applied for the detection of diacetyl for the first time. The measurement of acetoin and diacetyl with the same sensor setup is demonstrated. Finally, the successive detection of acetoin and diacetyl in buffer and in diluted beer is studied by tuning the sensitivity of the biosensor using the pH value of the measurement solution.},
  language  = {en}
}
@article{UysalFiratCreutzetal.2022,
  author    = {Uysal, Karya and Firat, Ipek Serat and Creutz, Till and Aydin, Inci Cansu and Artmann, Gerhard and Teusch, Nicole and Temiz Artmann, Ayseg{\"u}l},
  title     = {A novel in vitro wound healing assay using free-standing, ultra-thin PDMS membranes},
  series = {membranes},
  volume    = {2023},
  journal   = {membranes},
  number    = {13(1)},
  publisher = {MDPI},
  address   = {Basel},
  doi       = {10.3390/membranes13010022},
  pages     = {Artikel 22},
  year      = {2022},
  abstract  = {Advances in polymer science have significantly increased polymer applications in life sciences. We report the use of free-standing, ultra-thin polydimethylsiloxane (PDMS) membranes, called CellDrum, as cell culture substrates for an in vitro wound model. Dermal fibroblast monolayers from 28- and 88-year-old donors were cultured on CellDrums. By using stainless steel balls, circular cell-free areas were created in the cell layer (wounding). Sinusoidal strain of 1 Hz, 5\% strain, was applied to membranes for 30 min in 4 sessions. The gap circumference and closure rate of un-stretched samples (controls) and stretched samples were monitored over 4 days to investigate the effects of donor age and mechanical strain on wound closure. A significant decrease in gap circumference and an increase in gap closure rate were observed in trained samples from younger donors and control samples from older donors. In contrast, a significant decrease in gap closure rate and an increase in wound circumference were observed in the trained samples from older donors. Through these results, we propose the model of a cell monolayer on stretchable CellDrums as a practical tool for wound healing research. The combination of biomechanical cell loading in conjunction with analyses such as gene/protein expression seems promising beyond the scope published here.},
  language  = {en}
}