@article{LuisierLempiaeinenScherbichleretal.2014,
  author    = {Luisier, Rapha{\"e}lle and Lempi{\"a}inen, Harri and Scherbichler, Nina and Braeuning, Albert and Geissler, Miriam and Dubost, Valerie and M{\"u}ller, Arne and Scheer, Nico and Chibout, Salah-Dine and Hara, Hisanori and Picard, Frank and Theil, Diethilde and Couttet, Philippe and Vitobello, Antonio and Grenet, Olivier and Grasl-Kraupp, Bettina and Ellinger-Ziegelbauer, Heidrung and Thomson, John P. and Meehan, Richard R. and Elcombe, Clifford R. and Henderson, Colin J. and Wolf, C. Roland and Schwarz, Michael and Moulin, Pierre and Terranova, Remi and Moggs, Jonathan G.},
  title     = {Phenobarbital Induces Cell Cycle Transcriptional Responses in Mouse Liver Humanized for Constitutive Androstane and Pregnane X Receptors},
  series = {Toxicological Sciences},
  volume    = {139},
  journal   = {Toxicological Sciences},
  number    = {2},
  publisher = {Oxford University Press},
  address   = {Oxford},
  issn      = {1094-2025},
  doi       = {https://doi.org/10.1093/toxsci/kfu038},
  pages     = {501 -- 511},
  year      = {2014},
  abstract  = {The constitutive androstane receptor (CAR) and the pregnane X receptor (PXR) are closely related nuclear receptors involved in drug metabolism and play important roles in the mechanism of phenobarbital (PB)-induced rodent nongenotoxic hepatocarcinogenesis. Here, we have used a humanized CAR/PXR mouse model to examine potential species differences in receptor-dependent mechanisms underlying liver tissue molecular responses to PB. Early and late transcriptomic responses to sustained PB exposure were investigated in liver tissue from double knock-out CAR and PXR (CARᴷᴼ-PXRᴷᴼ), double humanized CAR and PXR (CARʰ-PXRʰ), and wild-type C57BL/6 mice. Wild-type and CARʰ-PXRʰ mouse livers exhibited temporally and quantitatively similar transcriptional responses during 91 days of PB exposure including the sustained induction of the xenobiotic response gene Cyp2b10, the Wnt signaling inhibitor Wisp1, and noncoding RNA biomarkers from the Dlk1-Dio3 locus. Transient induction of DNA replication (Hells, Mcm6, and Esco2) and mitotic genes (Ccnb2, Cdc20, and Cdk1) and the proliferation-related nuclear antigen Mki67 were observed with peak expression occurring between 1 and 7 days PB exposure. All these transcriptional responses were absent in CARᴷᴼ-PXRᴷᴼ mouse livers and largely reversible in wild-type and CARʰ-PXRʰ mouse livers following 91 days of PB exposure and a subsequent 4-week recovery period. Furthermore, PB-mediated upregulation of the noncoding RNA Meg3, which has recently been associated with cellular pluripotency, exhibited a similar dose response and perivenous hepatocyte-specific localization in both wild-type and CARʰ-PXRʰ mice. Thus, mouse livers coexpressing human CAR and PXR support both the xenobiotic metabolizing and the proliferative transcriptional responses following exposure to PB.},
  language  = {en}
}
@article{BlockViebahnJungbluth2024,
  author    = {Block, Simon and Viebahn, Peter and Jungbluth, Christian},
  title     = {Analysing direct air capture for enabling negative emissions in Germany: an assessment of the resource requirements and costs of a potential rollout in 2045},
  series = {Frontiers in Climate},
  volume    = {6},
  journal   = {Frontiers in Climate},
  publisher = {Frontiers},
  address   = {Lausanne},
  issn      = {2624-9553},
  doi       = {10.3389/fclim.2024.1353939},
  pages     = {18 Seiten},
  year      = {2024},
  abstract  = {Direct air capture (DAC) combined with subsequent storage (DACCS) is discussed as one promising carbon dioxide removal option. The aim of this paper is to analyse and comparatively classify the resource consumption (land use, renewable energy and water) and costs of possible DAC implementation pathways for Germany. The paths are based on a selected, existing climate neutrality scenario that requires the removal of 20 Mt of carbon dioxide (CO2) per year by DACCS from 2045. The analysis focuses on the so-called "low-temperature" DAC process, which might be more advantageous for Germany than the "high-temperature" one. In four case studies, we examine potential sites in northern, central and southern Germany, thereby using the most suitable renewable energies for electricity and heat generation. We show that the deployment of DAC results in large-scale land use and high energy needs. The land use in the range of 167-353 km2 results mainly from the area required for renewable energy generation. The total electrical energy demand of 14.4 TWh per year, of which 46\% is needed to operate heat pumps to supply the heat demand of the DAC process, corresponds to around 1.4\% of Germany's envisaged electricity demand in 2045. 20 Mt of water are provided yearly, corresponding to 40\% of the city of Cologne's water demand (1.1 million inhabitants). The capture of CO2 (DAC) incurs levelised costs of 125-138 EUR per tonne of CO2, whereby the provision of the required energy via photovoltaics in southern Germany represents the lowest value of the four case studies. This does not include the costs associated with balancing its volatility. Taking into account transporting the CO2 via pipeline to the port of Wilhelmshaven, followed by transporting and sequestering the CO2 in geological storage sites in the Norwegian North Sea (DACCS), the levelised costs increase to 161-176 EUR/tCO2. Due to the longer transport distances from southern and central Germany, a northern German site using wind turbines would be the most favourable.},
  language  = {en}
}
@misc{KrafftKukaUlberetal.2022,
  author    = {Krafft, Simone and Kuka, Katrin and Ulber, Roland and Tippk{\"o}tter, Nils},
  title     = {Utilization of Lolium perenne varieties as a renewable substrate for single-cell proteins, lactate, and composite materials},
  series = {Chemie Ingenieur Technik},
  volume    = {94},
  journal   = {Chemie Ingenieur Technik},
  number    = {9},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {0009-286X},
  doi       = {10.1002/cite.202255306},
  pages     = {1303 -- 1304},
  year      = {2022},
  abstract  = {Lolium perenne (perennial ryegrass) is aproductive and high-quality forage grass indigenous to Southern Europe, temperate Asia, and North Africa. Nowadays it is widespread and the dominant grass species on green areas in temperate climates. This abundant source of biomass is suitable for the development of bioeconomic processes because of its high cellulose and water-soluble carbohydrate content. In this work, novel breeds of the perennial ryegrass are being examined with regards to their quality parameters and biotechnological utilization options within the context of bioeconomy. Three processing operations are presented. In the first process, the perennial ryegrass is pretreated by pressing or hydrothermal extraction to derive glucosevia subsequent enzymatic hydrolysis of cellulose. A yield of up to 82 \% glucose was achieved when using the hydrothermal ex-traction as pretreatment. In a second process, the ryegrass is used to produce lactic acid in high concentrations. The influence of the growth conditions and the cutting time on the carboxylic acid yield is investigated. A yield of lactic acid of above 150 g kg⁻¹ dry matter was achieved. The third process is to use Lolium perenne as a substrate in the fermentation of K. marxianus for the microbial production of single-cell proteins. The perennial ryegrass is screw-pressed and the press juice is used as medium. When supplementing the press juice with yeast media components, a biomass concentration of up to 16 g L⁻¹ could be achieved.},
  language  = {en}
}
@article{BhattaraiStaat2018,
  author    = {Bhattarai, Aroj and Staat, Manfred},
  title     = {Computational comparison of different textile implants to correct apical prolapse in females},
  series = {Current Directions in Biomedical Engineering},
  volume    = {4},
  journal   = {Current Directions in Biomedical Engineering},
  number    = {1},
  publisher = {De Gruyter},
  address   = {Berlin},
  doi       = {10.1515/cdbme-2018-0159},
  pages     = {661 -- 664},
  year      = {2018},
  abstract  = {Prosthetic textile implants of different shapes, sizes and polymers are used to correct the apical prolapse after hysterectomy (removal of the uterus). The selection of the implant before or during minimally invasive surgery depends on the patient's anatomical defect, intended function after reconstruction and most importantly the surgeon's preference. Weakness or damage of the supporting tissues during childbirth, menopause or previous pelvic surgeries may put females in higher risk of prolapse. Numerical simulations of reconstructed pelvic floor with weakened tissues and organ supported by textile product models: DynaMesh®-PRS soft, DynaMesh®-PRP soft and DynaMesh®-CESA from FEG Textiletechnik mbH, Germany are compared.},
  language  = {en}
}
@misc{HoehnerDultmeyerWahle1993,
  author    = {H{\"o}hner, Peter and Dultmeyer, Josef and Wahle, Michael},
  title     = {Federanordnung f{\"u}r einen Rollstuhl : Offenlegungsschrift / Europ{\"a}ische Patentschrift},
  publisher = {Deutsches Patent- und Markenamt / Europ{\"a}isches Patentamt / United States Patent and Trademark Office},
  address   = {M{\"u}nchen / Den Hague u.a.},
  pages     = {4 S. : Ill.},
  year      = {1993},
  language  = {de}
}
@inproceedings{BarnatMergner2017,
  author    = {Barnat, Miriam and Mergner, Julia},
  title     = {Forschungsbasierte Qualit{\"a}tsentwicklung am Beispiel der Analyse von Lernprozessen und der Wirksamkeit von F{\"o}rderprogrammen},
  series = {3. Internationale Tagung f{\"u}r Qualit{\"a}tsmanagement und Qualit{\"a}tsentwicklung im Hochschulbereich 2.-3. Februar 2017},
  booktitle = {3. Internationale Tagung f{\"u}r Qualit{\"a}tsmanagement und Qualit{\"a}tsentwicklung im Hochschulbereich 2.-3. Februar 2017},
  pages     = {28 Seiten},
  year      = {2017},
  language  = {de}
}
@article{BragardConradvanHoeketal.2011,
  author    = {Bragard, Michael and Conrad, M. and van Hoek, H. and De Doncker, R. W.},
  title     = {The integrated emitter turn-off thyristor (IETO) : an innovative thyristor-based high power semiconductor device using MOS assisted turn-off},
  series = {IEEE transactions on industry applications},
  volume    = {47},
  journal   = {IEEE transactions on industry applications},
  number    = {5},
  publisher = {IEEE},
  address   = {New York},
  issn      = {0093-9994},
  doi       = {10.1109/TIA.2011.2161432},
  pages     = {2175 -- 2182},
  year      = {2011},
  language  = {en}
}
@inproceedings{RingbeckHagebeuker2007,
  author    = {Ringbeck, Thorsten and Hagebeuker, Bianca},
  title     = {A 3D time of flight camera of object detection},
  series = {Optical 3-D measurement techniques VIII : applications in GIS, mapping, manufacturing, quality control, robotics, navigation, mobile mapping, medical imaging, cultural heritage, VR generation and animation; papers presented to the conference organized at ETH Zurich, Switzerland, July 9 - 12, 2007. - Vol. 1},
  booktitle = {Optical 3-D measurement techniques VIII : applications in GIS, mapping, manufacturing, quality control, robotics, navigation, mobile mapping, medical imaging, cultural heritage, VR generation and animation; papers presented to the conference organized at ETH Zurich, Switzerland, July 9 - 12, 2007. - Vol. 1},
  editor    = {Gr{\"u}n, Armin},
  publisher = {ETH},
  address   = {Z{\"u}rich},
  isbn      = {3-906467-67-8 (Gesamtwerk)},
  pages     = {1 -- 16},
  year      = {2007},
  language  = {en}
}
@incollection{Golland2024,
  author    = {Golland, Alexander},
  title     = {Kommentierung von \S\S 6 bis 10 EKD-Datenschutzgesetz},
  series = {EKD-Datenschutzgesetz. Datenschutzbestimmungen der evangelischen Kirche},
  booktitle = {EKD-Datenschutzgesetz. Datenschutzbestimmungen der evangelischen Kirche},
  editor    = {Wagner, Ralph},
  publisher = {Nomos},
  address   = {Baden-Baden},
  isbn      = {978-3-8487-8111-9},
  pages     = {153 -- 228},
  year      = {2024},
  language  = {de}
}
@misc{TippkoetterWiesenThieletal.2014,
  author    = {Tippk{\"o}tter, Nils and Wiesen, S. and Thiel, A. and Muffler, K. and Ulber, Roland},
  title     = {Biotechnologische Wertstoffgewinnung entlang der Prozessketten Gr{\"u}ner und Pflanzen{\"o}l-Bioraffinerien},
  series = {Chemie Ingenieur Technik},
  volume    = {86},
  journal   = {Chemie Ingenieur Technik},
  number    = {9},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {0009-286X},
  doi       = {10.1002/cite.201450283},
  pages     = {1605},
  year      = {2014},
  abstract  = {Der nachwachsende Rohstoff Raps ist in großen Mengen verf{\"u}gbar und eine Quelle f{\"u}r Biomolek{\"u}le mit hohem Wertsch{\"o}pfungspotenzial. Entwicklungen zur biotechnologischen Wertstoffgewinnung werden dabei schwerpunktm{\"a}ßig in den Bereichen Aufarbeitung und Funktionalisierung von Polyphenolen und Fetten betrieben. Bei der Verarbeitung der Pflanzenmaterialien werden dabei insbesondere Verfahren zur adsorptiven Aufreinigung und Auftrennung mittels Materialien mit modifizierten Bleicherden und anderen organischen oder anorganischen Adsorbentien untersucht. Ferner wurden f{\"u}r die Aufreinigung von Polyphenolen adsorptive sowie extraktive Prozesse entwickelt. Bei den Entwicklungen wird ber{\"u}cksichtigt, dass Bioraffinerien auf eine fortw{\"a}hrende Gew{\"a}hrleistung eines hohen Produktions- bzw. Lieferbedarfs nachwachsender Rohstoffe angewiesen sind. Somit werden Optionen dezentraler regionaler Vorbehandlungs- und Wertsch{\"o}pfungsketten in der N{\"a}he landwirtschaftlicher Betriebe einbezogen. Neben neuen Aufreinigungsverfahren werden mikrobielle und enzymatische Prozesse zur wertsteigernden Umsetzung von Glycerin, Polyphenolen und Zuckermonomeren vorgestellt sowie Limitierungen nachwachsender Rohstoffe der 2. Generation diskutiert.},
  language  = {de}
}
@article{ScheerMclaughlinRodeetal.2014,
  author    = {Scheer, Nico and Mclaughlin, Lesley A. and Rode, Anja and MacLeod, Alastair Kenneth and Henderson, Colin J. and Wolf, Roland C.},
  title     = {Deletion of thirty murine cytochrome P450 genes results in viable mice with compromised drug metabolism},
  series = {Drug Metabolism and Disposition},
  volume    = {42},
  journal   = {Drug Metabolism and Disposition},
  number    = {6},
  publisher = {ASPET},
  address   = {Bethesda, Md.},
  issn      = {1521-009X},
  doi       = {10.1124/dmd.114.057885},
  pages     = {1022 -- 1030},
  year      = {2014},
  abstract  = {In humans, 75\% of all drugs are metabolized by the cytochrome P450-dependent monooxygenase system. Enzymes encoded by the CYP2C, CYP2D, and CYP3A gene clusters account for ∼80\% of this activity. There are profound species differences in the multiplicity of cytochrome P450 enzymes, and the use of mouse models to predict pathways of drug metabolism is further complicated by overlapping substrate specificity between enzymes from different gene families. To establish the role of the hepatic and extrahepatic P450 system in drug and foreign chemical disposition, drug efficacy, and toxicity, we created a unique mouse model in which 30 cytochrome P450 genes from the Cyp2c, Cyp2d, and Cyp3a gene clusters have been deleted. Remarkably, despite a wide range of putative important endogenous functions, Cyp2c/2d/3a KO mice were viable and fertile, demonstrating that these genes have evolved primarily as detoxification enzymes. Although there was no overt phenotype, detailed examination showed Cyp2c/2d/3a KO mice had a smaller body size (15\%) and larger livers (20\%). Changes in hepatic morphology and a decreased blood glucose (30\%) were also noted. A five-drug cocktail of cytochrome P450 isozyme probe substrates were used to evaluate changes in drug pharmacokinetics; marked changes were observed in either the pharmacokinetics or metabolites formed from Cyp2c, Cyp2d, and Cyp3a substrates, whereas the metabolism of the Cyp1a substrate caffeine was unchanged. Thus, Cyp2c/2d/3a KO mice provide a powerful model to study the in vivo role of the P450 system in drug metabolism and efficacy, as well as in chemical toxicity.},
  language  = {en}
}
@article{Kleefeld2021,
  author    = {Kleefeld, Andreas},
  title     = {The hot spots conjecture can be false: some numerical examples},
  series = {Advances in Computational Mathematics},
  volume    = {47},
  journal   = {Advances in Computational Mathematics},
  publisher = {Springer},
  address   = {Dordrecht},
  issn      = {1019-7168},
  doi       = {10.1007/s10444-021-09911-5},
  year      = {2021},
  abstract  = {The hot spots conjecture is only known to be true for special geometries. This paper shows numerically that the hot spots conjecture can fail to be true for easy to construct bounded domains with one hole. The underlying eigenvalue problem for the Laplace equation with Neumann boundary condition is solved with boundary integral equations yielding a non-linear eigenvalue problem. Its discretization via the boundary element collocation method in combination with the algorithm by Beyn yields highly accurate results both for the first non-zero eigenvalue and its corresponding eigenfunction which is due to superconvergence. Additionally, it can be shown numerically that the ratio between the maximal/minimal value inside the domain and its maximal/minimal value on the boundary can be larger than 1 + 10- 3. Finally, numerical examples for easy to construct domains with up to five holes are provided which fail the hot spots conjecture as well.},
  language  = {en}
}
@misc{BurlageHoeraufKlandtetal.1998,
  author    = {Burlage, Thomas and H{\"o}rauf, Martin and Klandt, Michael and Wahle, Michael},
  title     = {Schwingungsd{\"a}mpfer : Offenlegungsschrift},
  publisher = {Deutsches Patent- und Markenamt / Europ{\"a}isches Patentamt},
  address   = {M{\"u}nchen / Den Hague},
  pages     = {14 S. : graph. Darst.},
  year      = {1998},
  language  = {de}
}
@article{ScheerHendersonKapelyukhetal.2019,
  author    = {Scheer, Nico and Henderson, Colin James and Kapelyukh, Yury and Rode, Anja and Mclaren, Aileen W. and MacLeod, Alastair Kenneth and Lin, De and Wright, Jayne and Stanley, Lesley and Wolf, C. Roland},
  title     = {An extensively humanised mouse model to predict pathways of drug disposition, drug/drug interactions, and to facilitate the design of clinical trials},
  series = {Drug Metabolism and Disposition},
  journal   = {Drug Metabolism and Disposition},
  number    = {Early view},
  doi       = {10.1124/dmd.119.086397},
  pages     = {69 Seiten},
  year      = {2019},
  language  = {en}
}
@misc{TopcuMadabhushiStaat2022,
  author    = {Topcu, Murat and Madabhushi, Gopal Santana Phani and Staat, Manfred},
  title     = {Datasets from FEM Simulations done with COMSOL Multiphysics and Code_Aster},
  doi       = {10.6084/m9.figshare.19333295.v2},
  year      = {2022},
  abstract  = {Datasets from FEM Simulations done with COMSOL Multiphysics and Code_Aster for an elastic stress transfer between matrix and fibres having a variable radius.},
  language  = {en}
}
@incollection{RingbeckHagebeukerKraftetal.2007,
  author    = {Ringbeck, Thorsten and Hagebeuker, Bianca and Kraft, Holger and Paintner, Michael},
  title     = {PMD-basierte 3D-Optosensoren zur Fahrzeugumfelderfassung},
  series = {Sensoren im Automobil II : mit 27 Tabellen / [2. Tagung Sensoren im Automobil 2007]},
  booktitle = {Sensoren im Automobil II : mit 27 Tabellen / [2. Tagung Sensoren im Automobil 2007]},
  editor    = {Tille, Thomas},
  publisher = {expert-Verl.},
  address   = {Renningen},
  isbn      = {978-3-8169-2750-1},
  year      = {2007},
  language  = {de}
}
@article{Raatschen1987,
  author    = {Raatschen, Hans-J{\"u}rgen},
  title     = {Fokussierung von Spannungswellen in einer krummlinig berandeten Scheibe},
  series = {ZAMM : Zeitschrift f{\"u}r Angewandte Mathematik und Mechanik},
  volume    = {67},
  journal   = {ZAMM : Zeitschrift f{\"u}r Angewandte Mathematik und Mechanik},
  number    = {4},
  issn      = {1521-4001},
  pages     = {T230 -- T231},
  year      = {1987},
  language  = {de}
}
@book{Wahle1995,
  author    = {Wahle, Michael},
  title     = {Grundlagen der Maschinen- und Strukturdynamik. - (H{\"o}here Technische Mechanik ; 2)},
  edition   = {1. Aufl.},
  publisher = {Mainz},
  address   = {Aachen},
  isbn      = {3-930911-61-2},
  pages     = {216 S. : graph. Darst.},
  year      = {1995},
  language  = {de}
}
@article{GossmannFrotscherLinderetal.2016,
  author    = {Goßmann, Matthias and Frotscher, Ralf and Linder, Peter and Bayer, Robin and Epple, U. and Staat, Manfred and Temiz Artmann, Ayseg{\"u}l and Artmann, Gerhard},
  title     = {Mechano-pharmacological characterization of cardiomyocytes derived from human induced pluripotent stem cells},
  series = {Cellular physiology and biochemistry},
  volume    = {38},
  journal   = {Cellular physiology and biochemistry},
  number    = {3},
  publisher = {Karger},
  address   = {Basel},
  issn      = {1421-9778 (Online)},
  doi       = {10.1159/000443124},
  pages     = {1182 -- 1198},
  year      = {2016},
  abstract  = {Background/Aims: Common systems for the quantification of cellular contraction rely on animal-based models, complex experimental setups or indirect approaches. The herein presented CellDrum technology for testing mechanical tension of cellular monolayers and thin tissue constructs has the potential to scale-up mechanical testing towards medium-throughput analyses. Using hiPS-Cardiac Myocytes (hiPS-CMs) it represents a new perspective of drug testing and brings us closer to personalized drug medication. Methods: In the present study, monolayers of self-beating hiPS-CMs were grown on ultra-thin circular silicone membranes and deflect under the weight of the culture medium. Rhythmic contractions of the hiPS-CMs induced variations of the membrane deflection. The recorded contraction-relaxation-cycles were analyzed with respect to their amplitudes, durations, time integrals and frequencies. Besides unstimulated force and tensile stress, we investigated the effects of agonists and antagonists acting on Ca²⁺ channels (S-Bay K8644/verapamil) and Na⁺ channels (veratridine/lidocaine). Results: The measured data and simulations for pharmacologically unstimulated contraction resembled findings in native human heart tissue, while the pharmacological dose-response curves were highly accurate and consistent with reference data. Conclusion: We conclude that the combination of the CellDrum with hiPS-CMs offers a fast, facile and precise system for pharmacological, toxicological studies and offers new preclinical basic research potential.},
  language  = {en}
}
@inproceedings{KahraBreussKleefeldetal.2024,
  author    = {Kahra, Marvin and Breuß, Michael and Kleefeld, Andreas and Welk, Martin},
  title     = {An Approach to Colour Morphological Supremum Formation Using the LogSumExp Approximation},
  series = {Discrete Geometry and Mathematical Morphology},
  booktitle = {Discrete Geometry and Mathematical Morphology},
  editor    = {Brunetti, Sara and Frosini, Andrea and Rinaldi, Simone},
  publisher = {Springer},
  address   = {Cham},
  isbn      = {978-3-031-57793-2},
  doi       = {10.1007/978-3-031-57793-2_25},
  pages     = {325 -- 337},
  year      = {2024},
  abstract  = {Mathematical morphology is a part of image processing that has proven to be fruitful for numerous applications. Two main operations in mathematical morphology are dilation and erosion. These are based on the construction of a supremum or infimum with respect to an order over the tonal range in a certain section of the image. The tonal ordering can easily be realised in grey-scale morphology, and some morphological methods have been proposed for colour morphology. However, all of these have certain limitations. In this paper we present a novel approach to colour morphology extending upon previous work in the field based on the Loewner order. We propose to consider an approximation of the supremum by means of a log-sum exponentiation introduced by Maslov. We apply this to the embedding of an RGB image in a field of symmetric 2x2 matrices. In this way we obtain nearly isotropic matrices representing colours and the structural advantage of transitivity. In numerical experiments we highlight some remarkable properties of the proposed approach.},
  language  = {en}
}