@article{ScheerMclaughlinRodeetal.2014,
  author    = {Scheer, Nico and Mclaughlin, Lesley A. and Rode, Anja and MacLeod, Alastair Kenneth and Henderson, Colin J. and Wolf, Roland C.},
  title     = {Deletion of thirty murine cytochrome P450 genes results in viable mice with compromised drug metabolism},
  series = {Drug Metabolism and Disposition},
  volume    = {42},
  journal   = {Drug Metabolism and Disposition},
  number    = {6},
  publisher = {ASPET},
  address   = {Bethesda, Md.},
  issn      = {1521-009X},
  doi       = {10.1124/dmd.114.057885},
  pages     = {1022 -- 1030},
  year      = {2014},
  abstract  = {In humans, 75\% of all drugs are metabolized by the cytochrome P450-dependent monooxygenase system. Enzymes encoded by the CYP2C, CYP2D, and CYP3A gene clusters account for ∼80\% of this activity. There are profound species differences in the multiplicity of cytochrome P450 enzymes, and the use of mouse models to predict pathways of drug metabolism is further complicated by overlapping substrate specificity between enzymes from different gene families. To establish the role of the hepatic and extrahepatic P450 system in drug and foreign chemical disposition, drug efficacy, and toxicity, we created a unique mouse model in which 30 cytochrome P450 genes from the Cyp2c, Cyp2d, and Cyp3a gene clusters have been deleted. Remarkably, despite a wide range of putative important endogenous functions, Cyp2c/2d/3a KO mice were viable and fertile, demonstrating that these genes have evolved primarily as detoxification enzymes. Although there was no overt phenotype, detailed examination showed Cyp2c/2d/3a KO mice had a smaller body size (15\%) and larger livers (20\%). Changes in hepatic morphology and a decreased blood glucose (30\%) were also noted. A five-drug cocktail of cytochrome P450 isozyme probe substrates were used to evaluate changes in drug pharmacokinetics; marked changes were observed in either the pharmacokinetics or metabolites formed from Cyp2c, Cyp2d, and Cyp3a substrates, whereas the metabolism of the Cyp1a substrate caffeine was unchanged. Thus, Cyp2c/2d/3a KO mice provide a powerful model to study the in vivo role of the P450 system in drug metabolism and efficacy, as well as in chemical toxicity.},
  language  = {en}
}
@article{Kleefeld2021,
  author    = {Kleefeld, Andreas},
  title     = {The hot spots conjecture can be false: some numerical examples},
  series = {Advances in Computational Mathematics},
  volume    = {47},
  journal   = {Advances in Computational Mathematics},
  publisher = {Springer},
  address   = {Dordrecht},
  issn      = {1019-7168},
  doi       = {10.1007/s10444-021-09911-5},
  year      = {2021},
  abstract  = {The hot spots conjecture is only known to be true for special geometries. This paper shows numerically that the hot spots conjecture can fail to be true for easy to construct bounded domains with one hole. The underlying eigenvalue problem for the Laplace equation with Neumann boundary condition is solved with boundary integral equations yielding a non-linear eigenvalue problem. Its discretization via the boundary element collocation method in combination with the algorithm by Beyn yields highly accurate results both for the first non-zero eigenvalue and its corresponding eigenfunction which is due to superconvergence. Additionally, it can be shown numerically that the ratio between the maximal/minimal value inside the domain and its maximal/minimal value on the boundary can be larger than 1 + 10- 3. Finally, numerical examples for easy to construct domains with up to five holes are provided which fail the hot spots conjecture as well.},
  language  = {en}
}
@misc{BurlageHoeraufKlandtetal.1998,
  author    = {Burlage, Thomas and H{\"o}rauf, Martin and Klandt, Michael and Wahle, Michael},
  title     = {Schwingungsd{\"a}mpfer : Offenlegungsschrift},
  publisher = {Deutsches Patent- und Markenamt / Europ{\"a}isches Patentamt},
  address   = {M{\"u}nchen / Den Hague},
  pages     = {14 S. : graph. Darst.},
  year      = {1998},
  language  = {de}
}
@article{ScheerHendersonKapelyukhetal.2019,
  author    = {Scheer, Nico and Henderson, Colin James and Kapelyukh, Yury and Rode, Anja and Mclaren, Aileen W. and MacLeod, Alastair Kenneth and Lin, De and Wright, Jayne and Stanley, Lesley and Wolf, C. Roland},
  title     = {An extensively humanised mouse model to predict pathways of drug disposition, drug/drug interactions, and to facilitate the design of clinical trials},
  series = {Drug Metabolism and Disposition},
  journal   = {Drug Metabolism and Disposition},
  number    = {Early view},
  doi       = {10.1124/dmd.119.086397},
  pages     = {69 Seiten},
  year      = {2019},
  language  = {en}
}
@misc{TopcuMadabhushiStaat2022,
  author    = {Topcu, Murat and Madabhushi, Gopal Santana Phani and Staat, Manfred},
  title     = {Datasets from FEM Simulations done with COMSOL Multiphysics and Code_Aster},
  doi       = {10.6084/m9.figshare.19333295.v2},
  year      = {2022},
  abstract  = {Datasets from FEM Simulations done with COMSOL Multiphysics and Code_Aster for an elastic stress transfer between matrix and fibres having a variable radius.},
  language  = {en}
}
@incollection{RingbeckHagebeukerKraftetal.2007,
  author    = {Ringbeck, Thorsten and Hagebeuker, Bianca and Kraft, Holger and Paintner, Michael},
  title     = {PMD-basierte 3D-Optosensoren zur Fahrzeugumfelderfassung},
  series = {Sensoren im Automobil II : mit 27 Tabellen / [2. Tagung Sensoren im Automobil 2007]},
  booktitle = {Sensoren im Automobil II : mit 27 Tabellen / [2. Tagung Sensoren im Automobil 2007]},
  editor    = {Tille, Thomas},
  publisher = {expert-Verl.},
  address   = {Renningen},
  isbn      = {978-3-8169-2750-1},
  year      = {2007},
  language  = {de}
}
@article{Raatschen1987,
  author    = {Raatschen, Hans-J{\"u}rgen},
  title     = {Fokussierung von Spannungswellen in einer krummlinig berandeten Scheibe},
  series = {ZAMM : Zeitschrift f{\"u}r Angewandte Mathematik und Mechanik},
  volume    = {67},
  journal   = {ZAMM : Zeitschrift f{\"u}r Angewandte Mathematik und Mechanik},
  number    = {4},
  issn      = {1521-4001},
  pages     = {T230 -- T231},
  year      = {1987},
  language  = {de}
}
@book{Wahle1995,
  author    = {Wahle, Michael},
  title     = {Grundlagen der Maschinen- und Strukturdynamik. - (H{\"o}here Technische Mechanik ; 2)},
  edition   = {1. Aufl.},
  publisher = {Mainz},
  address   = {Aachen},
  isbn      = {3-930911-61-2},
  pages     = {216 S. : graph. Darst.},
  year      = {1995},
  language  = {de}
}
@article{GossmannFrotscherLinderetal.2016,
  author    = {Goßmann, Matthias and Frotscher, Ralf and Linder, Peter and Bayer, Robin and Epple, U. and Staat, Manfred and Temiz Artmann, Ayseg{\"u}l and Artmann, Gerhard},
  title     = {Mechano-pharmacological characterization of cardiomyocytes derived from human induced pluripotent stem cells},
  series = {Cellular physiology and biochemistry},
  volume    = {38},
  journal   = {Cellular physiology and biochemistry},
  number    = {3},
  publisher = {Karger},
  address   = {Basel},
  issn      = {1421-9778 (Online)},
  doi       = {10.1159/000443124},
  pages     = {1182 -- 1198},
  year      = {2016},
  abstract  = {Background/Aims: Common systems for the quantification of cellular contraction rely on animal-based models, complex experimental setups or indirect approaches. The herein presented CellDrum technology for testing mechanical tension of cellular monolayers and thin tissue constructs has the potential to scale-up mechanical testing towards medium-throughput analyses. Using hiPS-Cardiac Myocytes (hiPS-CMs) it represents a new perspective of drug testing and brings us closer to personalized drug medication. Methods: In the present study, monolayers of self-beating hiPS-CMs were grown on ultra-thin circular silicone membranes and deflect under the weight of the culture medium. Rhythmic contractions of the hiPS-CMs induced variations of the membrane deflection. The recorded contraction-relaxation-cycles were analyzed with respect to their amplitudes, durations, time integrals and frequencies. Besides unstimulated force and tensile stress, we investigated the effects of agonists and antagonists acting on Ca²⁺ channels (S-Bay K8644/verapamil) and Na⁺ channels (veratridine/lidocaine). Results: The measured data and simulations for pharmacologically unstimulated contraction resembled findings in native human heart tissue, while the pharmacological dose-response curves were highly accurate and consistent with reference data. Conclusion: We conclude that the combination of the CellDrum with hiPS-CMs offers a fast, facile and precise system for pharmacological, toxicological studies and offers new preclinical basic research potential.},
  language  = {en}
}
@inproceedings{KahraBreussKleefeldetal.2024,
  author    = {Kahra, Marvin and Breuß, Michael and Kleefeld, Andreas and Welk, Martin},
  title     = {An Approach to Colour Morphological Supremum Formation Using the LogSumExp Approximation},
  series = {Discrete Geometry and Mathematical Morphology},
  booktitle = {Discrete Geometry and Mathematical Morphology},
  editor    = {Brunetti, Sara and Frosini, Andrea and Rinaldi, Simone},
  publisher = {Springer},
  address   = {Cham},
  isbn      = {978-3-031-57793-2},
  doi       = {10.1007/978-3-031-57793-2_25},
  pages     = {325 -- 337},
  year      = {2024},
  abstract  = {Mathematical morphology is a part of image processing that has proven to be fruitful for numerous applications. Two main operations in mathematical morphology are dilation and erosion. These are based on the construction of a supremum or infimum with respect to an order over the tonal range in a certain section of the image. The tonal ordering can easily be realised in grey-scale morphology, and some morphological methods have been proposed for colour morphology. However, all of these have certain limitations. In this paper we present a novel approach to colour morphology extending upon previous work in the field based on the Loewner order. We propose to consider an approximation of the supremum by means of a log-sum exponentiation introduced by Maslov. We apply this to the embedding of an RGB image in a field of symmetric 2x2 matrices. In this way we obtain nearly isotropic matrices representing colours and the structural advantage of transitivity. In numerical experiments we highlight some remarkable properties of the proposed approach.},
  language  = {en}
}
@misc{SiekerTippkoetterUlberetal.2009,
  author    = {Sieker, T. and Tippk{\"o}tter, Nils and Ulber, Roland and Bart, H.-J. and Heinzle, E.},
  title     = {Nutzung von Silage zur fermentativen Produktion von Grund-und Feinchemikalien},
  series = {Chemie Ingenieur Technik},
  volume    = {81},
  journal   = {Chemie Ingenieur Technik},
  number    = {8},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {0009-286X},
  doi       = {10.1002/cite.200950271},
  pages     = {1207},
  year      = {2009},
  abstract  = {Grasschnitt hat in Deutschland ein betr{\"a}chtliches Potenzial als nachwachsender Rohstoff. Da frischer Grasschnitt nur in den Sommermonaten zur Verf{\"u}gung steht und Gras bei der Lagerung verrottet, wird er unter anderem durch Silierung konserviert. W{\"a}hrend der Silierung wird ein Teil der wasserl{\"o}slichen Kohlenhydrate unter anaeroben Bedingungen zu Milchs{\"a}ure fermentiert. Die Kombination aus Luftabschluss und Ans{\"a}uerung bewirkt die Konservierung der Silage. Silage als weit verbreitetes landwirtschaftliches Erzeugnis ist somit ein potentieller, in großen Mengen verf{\"u}gbarer Lieferant f{\"u}r eine Vielzahl von Substraten f{\"u}r mikrobielle Fermentationen. Diese k{\"o}nnen entweder durch die Hydrolyse der in den Pflanzen enthaltenen Cellulosen und Hemicellulosen oder durch die Verwendung eines Silagepresssaftes nutzbar gemacht werden. Die zu entwickelnden Prozesse sollen die verbleibenden Kohlenhydrate, inklusive der Cellulose und Hemicellulose, sowie die Milchs{\"a}ure nutzen. Die in der Silage enthaltenen Zucker sollen zu Ethanol, Itakons{\"a}ure und Bernsteins{\"a}ure und die Milchs{\"a}ure zu 1,2-Propandiol umgesetzt werden. Anfallende Reststoffe wie Hydrolyser{\"u}ckst{\"a}nde, Presskuchen und Fermentationsr{\"u}ckst{\"a}nde sollen bei allen zu etablierenden Prozessen entweder als Viehfutter verwendet oder der Biogasproduktion zugef{\"u}hrt werden k{\"o}nnen, wodurch eine vollst{\"a}ndige stoffliche und energetische Nutzung der Silage erreicht wird.},
  language  = {de}
}
@misc{SteuerDankertBergPostweilerLeichtScholten2023,
  author    = {Steuer-Dankert, Linda and Berg-Postweiler, Julia and Leicht-Scholten, Carmen},
  title     = {One does not fit all: applying anti-bias trainings in academia},
  series = {Twenty-third international conference on diversity in organizations, communities \& nations June 22 - 23, 2023 Toronto Metropolitan University, Rogers Communication Centre Toronto, Canada},
  journal   = {Twenty-third international conference on diversity in organizations, communities \& nations June 22 - 23, 2023 Toronto Metropolitan University, Rogers Communication Centre Toronto, Canada},
  year      = {2023},
  abstract  = {Anti-bias trainings are increasingly demanded and practiced in academia and industry to increase employees' sensitivity to discrimination, racism, and diversity. Under the heading of "Diversity Management", anti-bias trainings are mainly offered as one-off workshops intending to raise awareness of unconscious biases, create a diversity-affirming corporate culture, awake awareness of the potential of diversity, and ultimately enable the reflection of diversity in development processes. However, coming from childhood education, research and scientific articles on the sustainable effectiveness of anti-bias in adulthood, especially in academia, are very scarce. In order to fill this research gap, the paper explores how sustainable the effects of individual anti-bias trainings on the behavior of participants are. In order to investigate this, participant observation in a qualitative pre-post setting was conducted, analyzing anti-bias trainings in an academic context. Two observers actively participated in the training sessions and documented the activities and reflection processes of the participants. Overall, the results question the effectiveness of single anti-bias trainings and show that a target-group adaptive approach is mandatory due to the background of the approach in early childhood education. Therefore, it can be concluded that anti-bias work needs to be adapted to the target group's needs and reality of life. Furthermore, the study reveals that single anti-bias trainings must be embedded in a holistic diversity management approach to stimulate sustainable reflection processes among the target group. This paper is one of the first to scientifically evaluate anti-bias training effectiveness, especially in engineering sciences and the university context.},
  language  = {en}
}
@article{BertzMolinnusSchoeningetal.2023,
  author    = {Bertz, Morten and Molinnus, Denise and Sch{\"o}ning, Michael Josef and Homma, Takayuki},
  title     = {Real-time monitoring of H₂O₂ sterilization on individual bacillus atrophaeus spores by optical sensing with trapping Raman spectroscopy},
  series = {Chemosensors},
  volume    = {8},
  journal   = {Chemosensors},
  number    = {11},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2227-9040},
  doi       = {10.3390/chemosensors11080445},
  pages     = {Artikel 445},
  year      = {2023},
  abstract  = {Hydrogen peroxide (H₂O₂), a strong oxidizer, is a commonly used sterilization agent employed during aseptic food processing and medical applications. To assess the sterilization efficiency with H₂O₂, bacterial spores are common microbial systems due to their remarkable robustness against a wide variety of decontamination strategies. Despite their widespread use, there is, however, only little information about the detailed time-resolved mechanism underlying the oxidative spore death by H₂O₂. In this work, we investigate chemical and morphological changes of individual Bacillus atrophaeus spores undergoing oxidative damage using optical sensing with trapping Raman microscopy in real-time. The time-resolved experiments reveal that spore death involves two distinct phases: (i) an initial phase dominated by the fast release of dipicolinic acid (DPA), a major spore biomarker, which indicates the rupture of the spore's core; and (ii) the oxidation of the remaining spore material resulting in the subsequent fragmentation of the spores' coat. Simultaneous observation of the spore morphology by optical microscopy corroborates these mechanisms. The dependence of the onset of DPA release and the time constant of spore fragmentation on H₂O₂ shows that the formation of reactive oxygen species from H₂O₂ is the rate-limiting factor of oxidative spore death.},
  language  = {en}
}
@book{Czarnecki2023,
  author    = {Czarnecki, Christian},
  title     = {Angewandte Forschung in der Wirtschaftsinformatik 2023 : Tagungsband zur 36. AKWI-Jahrestagung},
  editor    = {Czarnecki, Christian and L{\"u}bbe, Alexander and Meister, Vera G. and M{\"u}ller, Christian and Steglich, Mike and Walther, Mathias},
  organization    = {Arbeitskreis Wirtschaftsinformatik an Hochschulen f{\"u}r Angewandte Wissenschaften im deutschsprachigen Raum (AKWI)},
  doi       = {10.15771/1794},
  pages     = {214 Seiten},
  year      = {2023},
  abstract  = {Beitr{\"a}ge der Fachtagung „Angewandte Forschung in der Wirtschaftsinformatik - Zukunft gestalten" im Rahmen der 36. Jahrestagung des Arbeitskreises Wirtschaftsinformatik an Hochschulen f{\"u}r Angewandte Wissenschaften (AKWI) vom 11. bis 13.09.2023 an der Technischen Hochschule Wildau},
  language  = {de}
}
@inproceedings{SteinbauerFerrein2019,
  author    = {Steinbauer, Gerald and Ferrein, Alexander},
  title     = {CogRob 2018 : Cognitive Robotics Workshop. Proceedings of the 11th Cognitive Robotics Workshop 2018 co-located with 16th International Conference on Principles of Knowledge Representation and Reasoning (KR 2018). Tempe, AZ, USA, October 27th, 2018.},
  series = {CEUR workshop proceedings},
  booktitle = {CEUR workshop proceedings},
  number    = {Vol-2325},
  issn      = {1613-0073},
  pages     = {46 Seiten},
  year      = {2019},
  language  = {en}
}
@book{OPUS4-5166,
  title     = {Kinetische Leuchtskulpturen : ein Projekt des Fachbereichs Gestaltung an der FH Aachen in Zusammenarbeit mit dem Rotary Club Aachen-Charlemagne},
  publisher = {FH Aachen},
  address   = {Aachen},
  pages     = {32 S. : zahlr. Ill.},
  year      = {2010},
  language  = {de}
}
@article{ThiebesKleinZingsheimetal.2022,
  author    = {Thiebes, Anja Lena and Klein, Sarah and Zingsheim, Jonas and M{\"o}ller, Georg H. and G{\"u}rzing, Stefanie and Reddemann, Manuel A. and Behbahani, Mehdi and Cornelissen, Christian G.},
  title     = {Effervescent atomizer as novel cell spray technology to decrease the gas-to-liquid ratio},
  series = {pharmaceutics},
  volume    = {14},
  journal   = {pharmaceutics},
  number    = {11},
  publisher = {MDPI},
  address   = {Basel},
  doi       = {10.3390/pharmaceutics14112421},
  pages     = {Artikel 2421},
  year      = {2022},
  abstract  = {Cell spraying has become a feasible application method for cell therapy and tissue engineering approaches. Different devices have been used with varying success. Often, twin-fluid atomizers are used, which require a high gas velocity for optimal aerosolization characteristics. To decrease the amount and velocity of required air, a custom-made atomizer was designed based on the effervescent principle. Different designs were evaluated regarding spray characteristics and their influence on human adipose-derived mesenchymal stromal cells. The arithmetic mean diameters of the droplets were 15.4-33.5 µm with decreasing diameters for increasing gas-to-liquid ratios. The survival rate was >90\% of the control for the lowest gas-to-liquid ratio. For higher ratios, cell survival decreased to approximately 50\%. Further experiments were performed with the design, which had shown the highest survival rates. After seven days, no significant differences in metabolic activity were observed. The apoptosis rates were not influenced by aerosolization, while high gas-to-liquid ratios caused increased necrosis levels. Tri-lineage differentiation potential into adipocytes, chondrocytes, and osteoblasts was not negatively influenced by aerosolization. Thus, the effervescent aerosolization principle was proven suitable for cell applications requiring reduced amounts of supplied air. This is the first time an effervescent atomizer was used for cell processing.},
  language  = {en}
}
@article{BreussKleefeld2020,
  author    = {Breuß, Michael and Kleefeld, Andreas},
  title     = {Implicit monotone difference methods for scalar conservation laws with source terms},
  series = {Acta Mathematica Vietnamica},
  volume    = {45},
  journal   = {Acta Mathematica Vietnamica},
  publisher = {Springer Singapore},
  address   = {Singapore},
  issn      = {2315-4144},
  doi       = {10.1007/s40306-019-00354-1},
  pages     = {709 -- 738},
  year      = {2020},
  abstract  = {In this article, a concept of implicit methods for scalar conservation laws in one or more spatial dimensions allowing also for source terms of various types is presented. This material is a significant extension of previous work of the first author (Breuß SIAM J. Numer. Anal. 43(3), 970-986 2005). Implicit notions are developed that are centered around a monotonicity criterion. We demonstrate a connection between a numerical scheme and a discrete entropy inequality, which is based on a classical approach by Crandall and Majda. Additionally, three implicit methods are investigated using the developed notions. Next, we conduct a convergence proof which is not based on a classical compactness argument. Finally, the theoretical results are confirmed by various numerical tests.},
  language  = {en}
}
@article{Gaigall2020,
  author    = {Gaigall, Daniel},
  title     = {Hoeffding-Blum-Kiefer-Rosenblatt independence test statistic on partly not identically distributed data},
  series = {Communications in Statistics - Theory and Methods},
  volume    = {51},
  journal   = {Communications in Statistics - Theory and Methods},
  number    = {12},
  publisher = {Taylor \& Francis},
  address   = {London},
  issn      = {1532-415X},
  doi       = {10.1080/03610926.2020.1805767},
  pages     = {4006 -- 4028},
  year      = {2020},
  abstract  = {The established Hoeffding-Blum-Kiefer-Rosenblatt independence test statistic is investigated for partly not identically distributed data. Surprisingly, it turns out that the statistic has the well-known distribution-free limiting null distribution of the classical criterion under standard regularity conditions. An application is testing goodness-of-fit for the regression function in a non parametric random effects meta-regression model, where the consistency is obtained as well. Simulations investigate size and power of the approach for small and moderate sample sizes. A real data example based on clinical trials illustrates how the test can be used in applications.},
  language  = {en}
}
@article{GollandKriegesmann2023,
  author    = {Golland, Alexander and Kriegesmann, Torben},
  title     = {Zivilprozessuale Fragen zum datenschutzrechtlichen Schadensersatzanspruch},
  series = {MMR - Zeitschrift f{\"u}r IT-Recht und Recht der Digitalisierung},
  journal   = {MMR - Zeitschrift f{\"u}r IT-Recht und Recht der Digitalisierung},
  number    = {10},
  publisher = {Beck},
  address   = {M{\"u}nchen},
  issn      = {2698-7988},
  pages     = {733 -- 739},
  year      = {2023},
  abstract  = {Im Verfahren gegen die {\"O}sterreichische Post AG (Rs. C-300/21) befasste sich der EuGH erstmals mit dem in Art. 82 DS-GVO geregelten datenschutzrechtlichen Schadensersatzanspruch. Mit den Klarstellungen des EuGH verschieben sich die Probleme nun st{\"a}rker zu den „klassischen" Fragen des Schadensersatzrechts im Zivilprozess. Relevant sind dabei vor allem Aspekte der Darlegungs- und Beweislast und deren Besonderheiten mit Blick auf den Ersatz immaterieller Sch{\"a}den. Der Beitrag fokussiert sich auf die Voraussetzungen und den dabei zu f{\"u}hrenden Tatsachenbeweis bei der Klage des Betroffenen gegen den Verantwortlichen auf Ersatz immaterieller Sch{\"a}den.},
  language  = {de}
}