@inproceedings{PijanowskaRemiszewskaPederzollietal.2006,
  author    = {Pijanowska, Dorota G. and Remiszewska, Elzbieta and Pederzolli, Cecilia and Lunelli, Lorenzo and Vendano, Michele and Canteri, Roberto and Dudzinski, Konrad and Kruk, Jerzy and Torbicz, Wladyslaw},
  title     = {Surface modification for microreactor fabrication},
  url       = {http://nbn-resolving.de/urn:nbn:de:hbz:a96-opus-1480},
  year      = {2006},
  abstract  = {In this paper, methods of surface modification of different supports, i.e. glass and polymeric beads for enzyme immobilisation are described. The developed method of enzyme immobilisation is based on Schiff's base formation between the amino groups on the enzyme surface and the aldehyde groups on the chemically modified surface of the supports. The surface of silicon modified by APTS and GOPS with immobilised enzyme was characterised by atomic force microscopy (AFM), time-of-flight secondary ion mass spectroscopy (ToF-SIMS) and infrared spectroscopy (FTIR). The supports with immobilised enzyme (urease) were also tested in combination with microreactors fabricated in silicon and Perspex, operating in a flow-through system. For microreactors filled with urease immobilised on glass beads (Sigma) and on polymeric beads (PAN), a very high and stable signal (pH change) was obtained. The developed method of urease immobilisation can be stated to be very effective.},
  subject      = {Biosensor},
  language  = {en}
}
@inproceedings{BukhariYang2006,
  author    = {Bukhari, Syed Faisal Ahmed and Yang, Wuqiang},
  title     = {Multi-interface level sensors and new development in monitoring and control of oil separators},
  url       = {http://nbn-resolving.de/urn:nbn:de:hbz:a96-opus-1498},
  year      = {2006},
  abstract  = {In the oil industry, huge saving may be made if suitable multi-interface level measurement systems are employed for effectively monitoring crude oil separators and efficient control of their operation. A number of techniques, e.g. externally mounted displacers, differential pressure transmitters and capacitance rod devices, have been developed to measure the separation process with gas, oil, water and other components. Because of the unavailability of suitable multi-interface level measurement systems, oil separators are currently operated by the trial-and-error approach. In this paper some conventional techniques, which have been used for level measurement in industry, and new development are discussed.},
  subject      = {Biosensor},
  language  = {en}
}
@inproceedings{TymeckiGlabKoncki2006,
  author    = {Tymecki, Lukasz and Glab, Stanislaw and Koncki, Robert},
  title     = {Miniaturized, planar ion-selective electrodes fabricated by means of thick-film technology},
  url       = {http://nbn-resolving.de/urn:nbn:de:hbz:a96-opus-1506},
  year      = {2006},
  abstract  = {Various planar technologies are employed for developing solid-state sensors having low cost, small size and high reproducibility; thin- and thick-film technologies are most suitable for such productions. Screen-printing is especially suitable due to its simplicity, low-cost, high reproducibility and efficiency in large-scale production. This technology enables the deposition of a thick layer and allows precise pattern control. Moreover, this is a highly economic technology, saving large amounts of the used inks. In the course of repetitions of the film-deposition procedure there is no waste of material due to additivity of this thick-film technology. Finally, the thick films can be easily and quickly deposited on inexpensive substrates. In this contribution, thick-film ion-selective electrodes based on ionophores as well as crystalline ion-selective materials dedicated for potentiometric measurements are demonstrated. Analytical parameters of these sensors are comparable with those reported for conventional potentiometric electrodes. All mentioned thick-film strip electrodes have been totally fabricated in only one, fully automated thickfilm technology, without any additional manual, chemical or electrochemical steps. In all cases simple, inexpensive, commercially available materials, i.e. flexible, plastic substrates and easily cured polymer-based pastes were used.},
  subject      = {Biosensor},
  language  = {en}
}
@inproceedings{SpannhakeSchulzHelwigetal.2006,
  author    = {Spannhake, Jan and Schulz, Olaf and Helwig, Andreas and Krenkow, Angelika and M{\"u}ller, Gerhard and Doll, Theodor},
  title     = {High-temperature MEMS heater platforms: long-term performance of metal and semiconductor heater materials},
  url       = {http://nbn-resolving.de/urn:nbn:de:hbz:a96-opus-1513},
  year      = {2006},
  abstract  = {Micromachined thermal heater platforms offer low electrical power consumption and high modulation speed, i.e. properties which are advantageous for realizing nondispersive infrared (NDIR) gas- and liquid monitoring systems. In this paper, we report on investigations on silicon-on-insulator (SOI) based infrared (IR) emitter devices heated by employing different kinds of metallic and semiconductor heater materials. Our results clearly reveal the superior high-temperature performance of semiconductor over metallic heater materials. Long-term stable emitter operation in the vicinity of 1300 K could be attained using heavily antimony-doped tin dioxide (SnO2:Sb) heater elements.},
  subject      = {Biosensor},
  language  = {en}
}
@inproceedings{KatzWillner2006,
  author    = {Katz, Eugenii and Willner, Itamar},
  title     = {Magneto-controlled quantized electron transfer to surface-confined redox units and metal nanoparticles},
  url       = {http://nbn-resolving.de/urn:nbn:de:hbz:a96-opus-1528},
  year      = {2006},
  abstract  = {Hydrophobic magnetic nanoparticles (NPs) consisting of undecanoate-capped magnetite (Fe3O4, average diameter ca. 5 nm) are used to control quantized electron transfer to surface-confined redox units and metal NPs. A two-phase system consisting of an aqueous electrolyte solution and a toluene phase that includes the suspended undecanoatecapped magnetic NPs is used to control the interfacial properties of the electrode surface. The attracted magnetic NPs form a hydrophobic layer on the electrode surface resulting in the change of the mechanisms of the surface-confined electrochemical processes. A quinone-monolayer modified Au electrode demonstrates an aqueous-type of the electrochemical process (2e-+2H+ redox mechanism) for the quinone units in the absence of the hydrophobic magnetic NPs, while the attraction of the magnetic NPs to the surface results in the stepwise single-electron transfer mechanism characteristic of a dry nonaqueous medium. Also, the attraction of the hydrophobic magnetic NPs to the Au electrode surface modified with Au NPs (ca. 1.4 nm) yields a microenvironment with a low dielectric constant that results in the single-electron quantum charging of the Au NPs.},
  subject      = {Biosensor},
  language  = {en}
}
@inproceedings{PijanowskaRemiszewska2006,
  author    = {Pijanowska, Dorota G. and Remiszewska, Elzbieta},
  title     = {pH-based detection of phenylalnine by potentiometric and colorimetric methods},
  url       = {http://nbn-resolving.de/urn:nbn:de:hbz:a96-opus-1536},
  year      = {2006},
  abstract  = {In this paper, methods of sample preparation for potentiometric measurement of phenylalanine are presented. Basing on the spectrophotometric measurements of phenylalanine, the concentrations of reagents of the enzymatic reaction (10 mM L-Phe, 0,4 mM NAD+, 2U L-PheDH) were determined. Then, the absorption spectrum of the reaction product, NADH, was monitored (maximum peak at 340 nm). The results obtained by the spectrophotometric method were compared with the results obtained by the colourimetry, using pH indicators. The above-mentioned two methods will be used as references for potentiometric measurements of phenylalanine concentration.},
  subject      = {Biosensor},
  language  = {en}
}
@inproceedings{AridaKloockSchoening2006,
  author    = {Arida, Hassan A. and Kloock, Joachim P. and Sch{\"o}ning, Michael Josef},
  title     = {Novel organic membrane-based thin-film microsensors for the determination of heavy metal cations},
  url       = {http://nbn-resolving.de/urn:nbn:de:hbz:a96-opus-1545},
  year      = {2006},
  abstract  = {A first step towards the fabrication and electrochemical evaluation of thin-film microsensors based on organic PVC membranes for the determination of Hg(II), Cd(II), Pb(II) and Cu(II) ions in solutions has been realised. The membrane-coating mixture used in the preparation of this new type of microsensors is incorporating PVC as supporting matrix, o-nitrophenyloctylether (o-NPOE) as solvent mediator and a recently synthesized Hg[dimethylglyoxime(phene)]2+ and Bis-(4-hydroxyacetophenone)-ethylenediamine as electroactive materials for Hg(II) and Cd(II), respectively. A set of three commercialised ionophores for Cd(II), Pb(II) and Cu(II) has been also used for comparison. Thin-film microsensors based on these membranes showed a Nernstian response of slope (26-30 mV/dec.) for the respective tested cations. The potentiometric response characteristics (linear range, pH range, detection limit and response time) are comparable with those obtained by conventional membranes as well as coated wire electrodes prepared from the same membrane. The realisation of the new organic membrane-based thin-film microsensors overcomes the problem of an insufficient selectivity of solid-state-based thinfilm sensors.},
  subject      = {Biosensor},
  language  = {en}
}
@inproceedings{BarekFischerNavratiletal.2006,
  author    = {Barek, Jiri and Fischer, Jan and Navratil, Tomas and Peckova, Karolina and Yosypchuk, Bogdan},
  title     = {Silver solid amalgam electrodes as sensors for chemical carcinogens},
  url       = {http://nbn-resolving.de/urn:nbn:de:hbz:a96-opus-1554},
  year      = {2006},
  abstract  = {The applicability of differential pulse voltammetry (DPV) and adsorptive stripping voltammetry (AdSV) at a non-toxic meniscus-modified silver solid amalgam electrode (m-AgSAE) for the determination of trace amounts of genotoxic substances was demonstrated on the determination of micromolar and submicromolar concentrations of 3-nitrofluoranthene using methanol - 0.01 mol L-1 NaOH (9:1) mixture as a base electrolyte and of Ostazine Orange using 0.01 mol L-1 NaOH as a base electrolyte.},
  subject      = {Biosensor},
  language  = {en}
}
@inproceedings{BaronasIvanauskasKulys2006,
  author    = {Baronas, Romas and Ivanauskas, Feliksas and Kulys, Juozas},
  title     = {Mathematical modeling of biosensors based on an array of enzyme microreactors},
  url       = {http://nbn-resolving.de/urn:nbn:de:hbz:a96-opus-1569},
  year      = {2006},
  abstract  = {This paper presents a two-dimensional-in-space mathematical model of biosensors based on an array of enzyme microreactors immobilised on a single electrode. The modeling system acts under amperometric conditions. The microreactors were modeled by particles and by strips. The model is based on the diffusion equations containing a nonlinear term related to the Michaelis-Menten kinetics of the enzymatic reaction. The model involves three regions: an array of enzyme microreactors where enzyme reaction as well as mass transport by diffusion takes place, a diffusion limiting region where only the diffusion takes place, and a convective region, where the analyte concentration is maintained constant. Using computer simulation, the influence of the geometry of the microreactors and of the diffusion region on the biosensor response was investigated. The digital simulation was carried out using the finite difference technique.},
  subject      = {Biosensor},
  language  = {en}
}
@inproceedings{LeiMulchandaniChenetal.2006,
  author    = {Lei, Yu and Mulchandani, Priti and Chen, Wilfred and Mulchandani, Ashok},
  title     = {Biosensor for direct determination of fenitrothion and EPN using recombinant Pseudomonas putida JS444 with surface expressed organophosphorus hydrolase. 1. modified clark oxygen electrode},
  url       = {http://nbn-resolving.de/urn:nbn:de:hbz:a96-opus-1573},
  year      = {2006},
  abstract  = {This paper reports a first microbial biosensor for rapid and cost-effective determination of organophosphorus pesticides fenitrothion and EPN. The biosensor consisted of recombinant PNP-degrading/oxidizing bacteria Pseudomonas putida JS444 anchoring and displaying organophosphorus hydrolase (OPH) on its cell surface as biological sensing element and a dissolved oxygen electrode as the transducer. Surfaceexpressed OPH catalyzed the hydrolysis of fenitrothion and EPN to release 3-methyl-4-nitrophenol and p-nitrophenol, respectively, which were oxidized by the enzymatic machinery of Pseudomonas putida JS444 to carbon dioxide while consuming oxygen, which was measured and correlated to the concentration of organophosphates. Under the optimum operating conditions, the biosensor was able to measure as low as 277 ppb of fenitrothion and 1.6 ppm of EPN without interference from phenolic compounds and other commonly used pesticides such as carbamate pesticides, triazine herbicides and organophosphate pesticides without nitrophenyl substituent. The applicability of the biosensor to lake water was also demonstrated.},
  subject      = {Biosensor},
  language  = {en}
}
@inproceedings{Staat2006,
  author    = {Staat, Manfred},
  title     = {Problems and chances for probabilistic fracture mechanics in the analysis of steel pressure boundary reliability. - {\"U}berarb. Ausg.},
  year      = {2006},
  abstract  = {In: Technical feasibility and reliability of passive safety systems for nuclear power plants. Proceedings of an Advisory Group Meeting held in J{\"u}lich, 21-24 November 1994. - Vienna , 1996. - Seite: 43 - 55 IAEA-TECDOC-920 Abstract: It is shown that the difficulty for probabilistic fracture mechanics (PFM) is the general problem of the high reliability of a small population. There is no way around the problem as yet. Therefore what PFM can contribute to the reliability of steel pressure boundaries is demon­strated with the example of a typical reactor pressure vessel and critically discussed. Although no method is distinguishable that could give exact failure probabilities, PFM has several addi­tional chances. Upper limits for failure probability may be obtained together with trends for design and operating conditions. Further, PFM can identify the most sensitive parameters, improved control of which would increase reliability. Thus PFM should play a vital role in the analysis of steel pressure boundaries despite all shortcomings.},
  subject      = {Bruchmechanik},
  language  = {en}
}
@inproceedings{FrotscherStaat2015,
  author    = {Frotscher, Ralf and Staat, Manfred},
  title     = {Homogenization of a cardiac tissue construct},
  series = {CMBE15 : 4th International Conference on Computational \& Mathematical Biomedical Engineering ; 29th June - 1st July 2015 ; {\´E}cole Normale Sup{\´e}rieure de Cachan ; Cachan (Paris), France},
  booktitle = {CMBE15 : 4th International Conference on Computational \& Mathematical Biomedical Engineering ; 29th June - 1st July 2015 ; {\´E}cole Normale Sup{\´e}rieure de Cachan ; Cachan (Paris), France},
  editor    = {Nithiarasu, Perumal},
  publisher = {CMBE},
  address   = {[s.l.]},
  issn      = {2227-9385},
  pages     = {645 -- 648},
  year      = {2015},
  language  = {en}
}
@inproceedings{FrotscherDuongStaat2015,
  author    = {Frotscher, Ralf and Duong, Minh Tuan and Staat, Manfred},
  title     = {Simulating beating cardiomyocytes with electromechanical coupling},
  series = {II. International Conference on Biomedical Technology : 28-30 October 2015 Hannover, Germany / T. Lenarz, P. Wriggers (Eds.)},
  booktitle = {II. International Conference on Biomedical Technology : 28-30 October 2015 Hannover, Germany / T. Lenarz, P. Wriggers (Eds.)},
  organization    = {International Conference on Biomedical Technology <2, 2015, Hannover>},
  pages     = {1 -- 2},
  year      = {2015},
  language  = {en}
}
@inproceedings{StaatDuong2016,
  author    = {Staat, Manfred and Duong, Minh Tuan},
  title     = {Smoothed Finite Element Methods for Nonlinear Solid Mechanics Problems: 2D and 3D Case Studies},
  series = {Proceedings of the National Science and Technology Conference on Mechanical - Transportation Engineering (NSCMET 2016), 13th October 2016, Hanoi, Vietnam, Vol.2},
  booktitle = {Proceedings of the National Science and Technology Conference on Mechanical - Transportation Engineering (NSCMET 2016), 13th October 2016, Hanoi, Vietnam, Vol.2},
  pages     = {440 -- 445},
  year      = {2016},
  abstract  = {The Smoothed Finite Element Method (SFEM) is presented as an edge-based and a facebased techniques for 2D and 3D boundary value problems, respectively. SFEMs avoid shortcomings of the standard Finite Element Method (FEM) with lower order elements such as overly stiff behavior, poor stress solution, and locking effects. Based on the idea of averaging spatially the standard strain field of the FEM over so-called smoothing domains SFEM calculates the stiffness matrix for the same number of degrees of freedom (DOFs) as those of the FEM. However, the SFEMs significantly improve accuracy and convergence even for distorted meshes and/or nearly incompressible materials. Numerical results of the SFEMs for a cardiac tissue membrane (thin plate inflation) and an artery (tension of 3D tube) show clearly their advantageous properties in improving accuracy particularly for the distorted meshes and avoiding shear locking effects.},
  language  = {en}
}
@inproceedings{DuongJungFrotscheretal.2016,
  author    = {Duong, Minh Tuan and Jung, Alexander and Frotscher, Ralf and Staat, Manfred},
  title     = {A 3D electromechanical FEM-based model for cardiac tissue},
  series = {ECCOMAS Congress 2016, VII European Congress on Computational Methods in Applied Sciences and Engineering. Crete Island, Greece, 5-10 June 2016},
  booktitle = {ECCOMAS Congress 2016, VII European Congress on Computational Methods in Applied Sciences and Engineering. Crete Island, Greece, 5-10 June 2016},
  editor    = {Papadrakakis, M.},
  pages     = {13 S.},
  year      = {2016},
  language  = {en}
}
@inproceedings{SchreiberKraftZuendorf2017,
  author    = {Schreiber, Marc and Kraft, Bodo and Z{\"u}ndorf, Albert},
  title     = {Metrics Driven Research Collaboration: Focusing on Common Project Goals Continuously},
  series = {39th International Conference on Software Engineering, May 20-28, 2017 - Buenos Aires, Argentina},
  booktitle = {39th International Conference on Software Engineering, May 20-28, 2017 - Buenos Aires, Argentina},
  pages     = {8 Seiten},
  year      = {2017},
  abstract  = {Research collaborations provide opportunities for both practitioners and researchers: practitioners need solutions for difficult business challenges and researchers are looking for hard problems to solve and publish. Nevertheless, research collaborations carry the risk that practitioners focus on quick solutions too much and that researchers tackle theoretical problems, resulting in products which do not fulfill the project requirements. In this paper we introduce an approach extending the ideas of agile and lean software development. It helps practitioners and researchers keep track of their common research collaboration goal: a scientifically enriched software product which fulfills the needs of the practitioner's business model. This approach gives first-class status to application-oriented metrics that measure progress and success of a research collaboration continuously. Those metrics are derived from the collaboration requirements and help to focus on a commonly defined goal. An appropriate tool set evaluates and visualizes those metrics with minimal effort, and all participants will be pushed to focus on their tasks with appropriate effort. Thus project status, challenges and progress are transparent to all research collaboration members at any time.},
  language  = {en}
}
@inproceedings{JungFrotscherStaat2018,
  author    = {Jung, Alexander and Frotscher, Ralf and Staat, Manfred},
  title     = {Electromechanical model of hiPSC-derived ventricular cardiomyocytes cocultured with fibroblasts},
  series = {6th European Conference on Computational Mechanics (ECCM 6), 7th European Conference on Computational Fluid Dynamics (ECFD 7), 11-15 June 2018, Glasgow, UK},
  booktitle = {6th European Conference on Computational Mechanics (ECCM 6), 7th European Conference on Computational Fluid Dynamics (ECFD 7), 11-15 June 2018, Glasgow, UK},
  pages     = {11 Seiten},
  year      = {2018},
  abstract  = {The CellDrum provides an experimental setup to study the mechanical effects of fibroblasts co-cultured with hiPSC-derived ventricular cardiomyocytes. Multi-scale computational models based on the Finite Element Method are developed. Coupled electrical cardiomyocyte-fibroblast models (cell level) are embedded into reaction-diffusion equations (tissue level) which compute the propagation of the action potential in the cardiac tissue. Electromechanical coupling is realised by an excitation-contraction model (cell level) and the active stress arising during contraction is added to the passive stress in the force balance, which determines the tissue displacement (tissue level). Tissue parameters in the model can be identified experimentally to the specific sample.},
  language  = {en}
}
@article{AlexyukBogoyavlenskiyAlexyuketal.2021,
  author    = {Alexyuk, Madina and Bogoyavlenskiy, Andrey and Alexyuk, Pavel and Moldakhanov, Yergali and Berezin, Vladimir and Digel, Ilya},
  title     = {Epipelagic microbiome of the Small Aral Sea: Metagenomic structure and ecological diversity},
  series = {MicrobiologyOpen},
  volume    = {10},
  journal   = {MicrobiologyOpen},
  number    = {1},
  publisher = {Wiley},
  address   = {Weinheim},
  issn      = {2045-8827},
  doi       = {10.1002/mbo3.1142},
  pages     = {1 -- 10},
  year      = {2021},
  abstract  = {Microbial diversity studies regarding the aquatic communities that experienced or are experiencing environmental problems are essential for the comprehension of the remediation dynamics. In this pilot study, we present data on the phylogenetic and ecological structure of microorganisms from epipelagic water samples collected in the Small Aral Sea (SAS). The raw data were generated by massive parallel sequencing using the shotgun approach. As expected, most of the identified DNA sequences belonged to Terrabacteria and Actinobacteria (40\% and 37\% of the total reads, respectively). The occurrence of Deinococcus-Thermus, Armatimonadetes, Chloroflexi in the epipelagic SAS waters was less anticipated. Surprising was also the detection of sequences, which are characteristic for strict anaerobes—Ignavibacteria, hydrogen-oxidizing bacteria, and archaeal methanogenic species. We suppose that the observed very broad range of phylogenetic and ecological features displayed by the SAS reads demonstrates a more intensive mixing of water masses originating from diverse ecological niches of the Aral-Syr Darya River basin than presumed before.},
  language  = {en}
}
@article{HeelDiktaBraekers2021,
  author    = {Heel, Mareike van and Dikta, Gerhard and Braekers, Roel},
  title     = {Bootstrap based goodness‑of‑fit tests for binary multivariate regression models},
  series = {Journal of the Korean Statistical Society},
  volume    = {51},
  journal   = {Journal of the Korean Statistical Society},
  publisher = {Springer Nature},
  address   = {Singapur},
  issn      = {2005-2863 (Online)},
  doi       = {10.1007/s42952-021-00142-4},
  pages     = {28 Seiten},
  year      = {2021},
  abstract  = {We consider a binary multivariate regression model where the conditional expectation of a binary variable given a higher-dimensional input variable belongs to a parametric family. Based on this, we introduce a model-based bootstrap (MBB) for higher-dimensional input variables. This test can be used to check whether a sequence of independent and identically distributed observations belongs to such a parametric family. The approach is based on the empirical residual process introduced by Stute (Ann Statist 25:613-641, 1997). In contrast to Stute and Zhu's approach (2002) Stute \& Zhu (Scandinavian J Statist 29:535-545, 2002), a transformation is not required. Thus, any problems associated with non-parametric regression estimation are avoided. As a result, the MBB method is much easier for users to implement. To illustrate the power of the MBB based tests, a small simulation study is performed. Compared to the approach of Stute \& Zhu (Scandinavian J Statist 29:535-545, 2002), the simulations indicate a slightly improved power of the MBB based method. Finally, both methods are applied to a real data set.},
  language  = {en}
}
@article{BornheimGriegerBlanecketal.2024,
  author    = {Bornheim, Tobias and Grieger, Niklas and Blaneck, Patrick Gustav and Bialonski, Stephan},
  title     = {Speaker Attribution in German Parliamentary Debates with QLoRA-adapted Large Language Models},
  series = {Journal for language technology and computational linguistics : JLCL},
  volume    = {37},
  journal   = {Journal for language technology and computational linguistics : JLCL},
  number    = {1},
  publisher = {Gesellschaft f{\"u}r Sprachtechnologie und Computerlinguistik},
  address   = {Regensburg},
  issn      = {2190-6858},
  doi       = {10.21248/jlcl.37.2024.244},
  pages     = {13 Seiten},
  year      = {2024},
  abstract  = {The growing body of political texts opens up new opportunities for rich insights into political dynamics and ideologies but also increases the workload for manual analysis. Automated speaker attribution, which detects who said what to whom in a speech event and is closely related to semantic role labeling, is an important processing step for computational text analysis. We study the potential of the large language model family Llama 2 to automate speaker attribution in German parliamentary debates from 2017-2021. We fine-tune Llama 2 with QLoRA, an efficient training strategy, and observe our approach to achieve competitive performance in the GermEval 2023 Shared Task On Speaker Attribution in German News Articles and Parliamentary Debates. Our results shed light on the capabilities of large language models in automating speaker attribution, revealing a promising avenue for computational analysis of political discourse and the development of semantic role labeling systems.},
  language  = {en}
}