@article{PookhalilAmoabedinyTabeshetal.2016, author = {Pookhalil, Ali and Amoabediny, Ghassem and Tabesh, Hadi and Behbahani, Mehdi and Mottaghy, Khosrow}, title = {A new approach for semiempirical modeling of mechanical blood trauma}, series = {The international journal of artificial organs}, volume = {39}, journal = {The international journal of artificial organs}, number = {4}, publisher = {Sage}, address = {London}, issn = {1724-6040}, doi = {10.5301/ijao.5000474}, pages = {171 -- 177}, year = {2016}, abstract = {Purpose Two semi-empirical models were recently published, both making use of existing literature data, but each taking into account different physical phenomena that trigger hemolysis. In the first model, hemoglobin (Hb) release is described as a permeation procedure across the membrane, assuming a shear stress-dependent process (sublethal model). The second model only accounts for hemoglobin release that is caused by cell membrane breakdown, which occurs when red blood cells (RBC) undergo mechanically induced shearing for a period longer than the threshold time (nonuniform threshold model). In this paper, we introduce a model that considers the hemolysis generated by both these possible phenomena. Methods Since hemolysis can possibly be caused by permeation of hemoglobin through the RBC functional membrane as well as by release of hemoglobin from RBC membrane breakdown, our proposed model combines both these models. An experimental setup consisting of a Couette device was utilized for validation of our proposed model. Results A comparison is presented between the damage index (DI) predicted by the proposed model vs. the sublethal model vs. the nonthreshold model and experimental datasets. This comparison covers a wide range of shear stress for both human and porcine blood. An appropriate agreement between the measured DI and the DI predicted by the present model was obtained. Conclusions The semiempirical hemolysis model introduced in this paper aims for significantly enhanced conformity with experimental data. Two phenomenological outcomes become possible with the proposed approach: an estimation of the average time after which cell membrane breakdown occurs under the applied conditions, and a prediction of the ratio between the phenomena involved in hemolysis.}, language = {en} } @inproceedings{BhattaraiStaat2016, author = {Bhattarai, Aroj and Staat, Manfred}, title = {Female pelvic floor dysfunction: progress weakening of the support system}, series = {1st YRA MedTech Symposium 2016 : April 8th / 2016 / University of Duisburg-Essen}, booktitle = {1st YRA MedTech Symposium 2016 : April 8th / 2016 / University of Duisburg-Essen}, editor = {Erni, Daniel}, publisher = {Universit{\"a}t Duisburg-Essen}, address = {Duisburg}, organization = {MedTech Symposium}, doi = {10.17185/duepublico/40821}, pages = {11 -- 12}, year = {2016}, abstract = {The structure of the female pelvic floor (PF) is an inter-related system of bony pelvis,muscles, pelvic organs, fascias, ligaments, and nerves with multiple functions. Mechanically, thepelvic organ support system are of two types: (I) supporting system of the levator ani (LA) muscle,and (II) the suspension system of the endopelvic fascia condensation [1], [2]. Significantdenervation injury to the pelvic musculature, depolimerization of the collagen fibrils of the softvaginal hammock, cervical ring and ligaments during pregnancy and vaginal delivery weakens thenormal functions of the pelvic floor. Pelvic organ prolapse, incontinence, sexual dysfunction aresome of the dysfunctions which increases progressively with age and menopause due toweakened support system according to the Integral theory [3]. An improved 3D finite elementmodel of the female pelvic floor as shown in Fig. 1 is constructed that: (I) considers the realisticsupport of the organs to the pelvic side walls, (II) employs the improvement of our previous FEmodel [4], [5] along with the patient based geometries, (III) incorporates the realistic anatomy andboundary conditions of the endopelvic (pubocervical and rectovaginal) fascia, and (IV) considersvarying stiffness of the endopelvic fascia in the craniocaudal direction [3]. Several computationsare carried out on the presented computational model with healthy and damaged supportingtissues, and comparisons are made to understand the physiopathology of the female PF disorders.}, language = {en} } @inproceedings{JungStaat2016, author = {Jung, Alexander and Staat, Manfred}, title = {Computing olympic gold: Ski jumping as an example}, series = {1st YRA MedTech Symposium 2016 : April 8th / 2016 / University of Duisburg-Essen}, booktitle = {1st YRA MedTech Symposium 2016 : April 8th / 2016 / University of Duisburg-Essen}, editor = {Erni, Daniel}, publisher = {Universit{\"a}t Duisburg-Essen}, address = {Duisburg}, organization = {MedTech Symposium}, isbn = {978-3-940402-06-6}, doi = {10.17185/duepublico/40821}, pages = {54 -- 55}, year = {2016}, language = {en} } @inproceedings{KahmannHacklWegmannetal.2016, author = {Kahmann, Stephanie and Hackl, Michael and Wegmann, Kilian and M{\"u}ller, Lars-Peter and Staat, Manfred}, title = {Impact of a proximal radial shortening osteotomy on the distribution of forces and the stability of the elbow}, series = {1st YRA MedTech Symposium 2016 : April 8th / 2016 / University of Duisburg-Essen}, booktitle = {1st YRA MedTech Symposium 2016 : April 8th / 2016 / University of Duisburg-Essen}, editor = {Erni, Daniel}, publisher = {Universit{\"a}t Duisburg-Essen}, address = {Duisburg}, organization = {MedTech Symposium}, doi = {10.17185/duepublico/40821}, pages = {7 -- 8}, year = {2016}, abstract = {The human arm consists of the humerus (upper arm), the medial ulna and the lateral radius (forearm). The joint between the humerus and the ulna is called humeroulnar joint and the joint between the humerus and the radius is called humeroradial joint. Lateral and medial collateral ligaments stabilize the elbow. Statistically, 2.5 out of 10,000 people suffer from radial head fractures [1]. In these fractures the cartilage is often affected. Caused by the injured cartilage, degenerative diseases like posttraumatic arthrosis may occur. The resulting pain and reduced range of motion have an impact on the patient's quality of life. Until now, there has not been a treatment which allows typical loads in daily life activities and offers good long-term results. A new surgical approach was developed with the motivation to reduce the progress of the posttraumatic arthrosis. Here, the radius is shortened by 3 mm in the proximal part [2]. By this means, the load of the radius is intended to be reduced due to a load shift to the ulna. Since the radius is the most important stabilizer of the elbow it has to be confirmed that the stability is not affected. In the first test (Fig. 1 left), pressure distributions within the humeroulnar and humeroradial joints a native and a shortened radius were measured using resistive pressure sensors (I5076 and I5027, Tekscan, USA). The humerus was loaded axially in a tension testing machine (Z010, Zwick Roell, Germany) in 50 N steps up to 400 N. From the humerus the load is transmitted through both the radius and the ulna into the hand which is fixed on the ground. In the second test (Fig. 1 right), the joint stability was investigated using a digital image correlation system to measure the displacement of the ulna. Here, the humerus is fixed with a desired flexion angle and the unconstrained forearm lies on the ground. A rope connects the load actuator with a hook fixed in the ulna. A guide roller is used so that the rope pulls the ulna horizontally when a tensile load is applied. This creates a moment about the elbow joint with a maximum value of 7.5 Nm. Measurements were performed with varying flexion angles (0°, 30°, 60°, 90°, 120°). For both tests and each measurement, seven specimens were used. Student's t-test was employed to determine whether the mean values of the measurements in native specimen and operated specimens differ significantly.}, language = {en} } @article{ArreolaMaetzkowDuranetal.2016, author = {Arreola, Julio and M{\"a}tzkow, Malte and Dur{\´a}n, Marlena Palomar and Greeff, Anton and Keusgen, Michael and Sch{\"o}ning, Michael Josef}, title = {Optimization of the immobilization of bacterial spores on glass substrates with organosilanes}, series = {Physica status solidi (A) : Applications and materials science}, volume = {213}, journal = {Physica status solidi (A) : Applications and materials science}, number = {6}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1862-6319}, doi = {10.1002/pssa.201532914}, pages = {1463 -- 1470}, year = {2016}, abstract = {Spores can be immobilized on biosensors to function as sensitive recognition elements. However, the immobilization can affect the sensitivity and reproducibility of the sensor signal. In this work, three different immobilization strategies with organosilanes were optimized and characterized to immobilize Bacillus atrophaeus spores on glass substrates. Five different silanization parameters were investigated: nature of the solvent, concentration of the silane, silanization time, curing process, and silanization temperature. The resulting silane layers were resistant to a buffer solution (e.g., Ringer solution) with a polysorbate (e.g., Tween®80) and sonication.}, language = {en} } @article{WuPoghossianBronderetal.2016, author = {Wu, Chunsheng and Poghossian, Arshak and Bronder, Thomas and Sch{\"o}ning, Michael Josef}, title = {Sensing of double-stranded DNA molecules by their intrinsic molecular charge using the light-addressable potentiometric sensor}, series = {Sensors and Actuators B: Chemical}, journal = {Sensors and Actuators B: Chemical}, number = {229}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0925-4005}, doi = {10.1016/j.snb.2016.02.004}, pages = {506 -- 512}, year = {2016}, abstract = {A multi-spot light-addressable potentiometric sensor (LAPS), which belongs to the family of semiconductor field-effect devices, was applied for label-free detection of double-stranded deoxyribonucleic acid (dsDNA) molecules by their intrinsic molecular charge. To reduce the distance between the DNA charge and sensor surface and thus, to enhance the electrostatic coupling between the dsDNA molecules and the LAPS, the negatively charged dsDNA molecules were electrostatically adsorbed onto the gate surface of the LAPS covered with a positively charged weak polyelectrolyte layer of PAH (poly(allylamine hydrochloride)). The surface potential changes in each spot of the LAPS, induced by the layer-by-layer adsorption of a PAH/dsDNA bilayer, were recorded by means of photocurrent-voltage and constant-photocurrent measurements. In addition, the surface morphology of the gate surface before and after consecutive electrostatic adsorption of PAH and dsDNA layers was studied by atomic force microscopy measurements. Moreover, fluorescence microscopy was used to verify the successful adsorption of dsDNA molecules onto the PAH-modified LAPS surface. A high sensor signal of 25 mV was registered after adsorption of 10 nM dsDNA molecules. The lower detection limit is down to 0.1 nM dsDNA. The obtained results demonstrate that the PAH-modified LAPS device provides a convenient and rapid platform for the direct label-free electrical detection of in-solution hybridized dsDNA molecules.}, language = {en} } @inproceedings{Laack2016, author = {Laack, Walter van}, title = {Schnittstelle Tod: Wo stehen wir nach 40 Jahren NTE-Forschung?}, publisher = {van Laack GmbH}, address = {Aachen}, isbn = {978-3-936624-30-4 (Print-Ausgabe)}, url = {http://nbn-resolving.de/urn:nbn:de:101:1-201603132912}, pages = {92 Seiten}, year = {2016}, language = {de} } @inproceedings{TranTranMatthiesetal.2016, author = {Tran, Ngoc Trinh and Tran, Thanh Ngoc and Matthies, Hermann G. and Stavroulakis, Georgios Eleftherios and Staat, Manfred}, title = {FEM Shakedown of uncertain structures by chance constrained programming}, series = {PAMM Proceedings in Applied Mathematics and Mechanics}, volume = {16}, booktitle = {PAMM Proceedings in Applied Mathematics and Mechanics}, number = {1}, issn = {1617-7061}, doi = {10.1002/pamm.201610346}, pages = {715 -- 716}, year = {2016}, language = {en} } @article{LeversStaatLaack2016, author = {Levers, A. and Staat, Manfred and Laack, Walter van}, title = {Analysis of the long-term effect of the MBST® nuclear magnetic resonance therapy on gonarthrosis}, series = {Orthopedic Practice}, volume = {47}, journal = {Orthopedic Practice}, number = {11}, pages = {521 -- 528}, year = {2016}, language = {en} } @inproceedings{HafnerOchsWeickertetal.2016, author = {Hafner, David and Ochs, Peter and Weickert, Joachim and Reißel, Martin}, title = {FSI Schemes : Fast Semi-Iterative Solvers for PDEs and Optimisation Methods}, series = {Pattern Recognition : 38th German Conference, GCPR 2016, Hannover, Germany, September 12-15, 2016, Proceedings}, booktitle = {Pattern Recognition : 38th German Conference, GCPR 2016, Hannover, Germany, September 12-15, 2016, Proceedings}, editor = {Rosenhahn, Bodo}, publisher = {Springer}, isbn = {978-3-319-45886-1}, doi = {10.1007/978-3-319-45886-1_8}, pages = {91 -- 102}, year = {2016}, language = {de} } @inproceedings{TranTranMatthiesetal.2016, author = {Tran, Ngoc Trinh and Tran, Thanh Ngoc and Matthies, H. G. and Stavroulakis, G. E. and Staat, Manfred}, title = {Shakedown analysis of plate bending analysis under stochastic uncertainty by chance constrained programming}, series = {ECCOMAS Congress 2016, VII European Congress on Computational Methods in Applied Sciences and Engineering. Crete Island, Greece, 5-10 June 2016}, booktitle = {ECCOMAS Congress 2016, VII European Congress on Computational Methods in Applied Sciences and Engineering. Crete Island, Greece, 5-10 June 2016}, editor = {Papadrakakis, M.}, pages = {13 S.}, year = {2016}, language = {en} } @article{KotliarLanzl2016, author = {Kotliar, Konstantin and Lanzl, I. M.}, title = {Mit Statistik gemeistert: perfekte Augentropfen und idealer Screeningtest : M{\"o}glichkeiten und Grenzen statistischer Methoden beim Glaukom}, series = {Der Ophthalmologe: Zeitschrift Der Deutschen Ophthalmologischen Gesellschaft}, journal = {Der Ophthalmologe: Zeitschrift Der Deutschen Ophthalmologischen Gesellschaft}, number = {113}, publisher = {Springer}, address = {Berlin}, issn = {0941-293X}, doi = {10.1007/s00347-016-0312-y}, pages = {838 -- 843}, year = {2016}, abstract = {Hintergrund Die Anwendung und das Verst{\"a}ndnis von Statistik sind sehr wichtig f{\"u}r die biomedizinische Forschung und f{\"u}r die klinische Praxis. Dies gilt insbesondere auch zur Absch{\"a}tzung der M{\"o}glichkeiten unterschiedlichster Diagnostik- und Therapieoptionen beim Glaukom. Die scheinbare Komplexit{\"a}t der Statistik, die zum Teil dem „gesunden Menschenverstand" zu widersprechen scheint, zusammen mit der nur vorsichtigen Akzeptanz der Statistik bei vielen Medizinern k{\"o}nnen zu bewussten und unbewussten Manipulationen bei der Datendarstellung und -interpretation f{\"u}hren. Ziel der Arbeit Ziel ist die verst{\"a}ndliche Darstellung einiger typischer Fehler in der medizinisch-statistischen Datenbehandlung. Material und Methoden Anhand hypothetischer Beispiele aus der Glaukomdiagnostik erfolgen die Darstellung der Wirkung eines hypotensiven Medikamentes sowie die Beurteilung der Ergebnisse eines diagnostischen Tests. Es werden die typischsten statistischen Einsatzbereiche und Irrtumsquellen ausf{\"u}hrlich und verst{\"a}ndlich analysiert Ergebnisse Mechanismen von Datenmanipulation und falscher Dateninterpretation werden aufgekl{\"a}rt. Typische Irrtumsquellen bei der statistischen Auswertung und Datendarstellung werden dabei erl{\"a}utert. Schlussfolgerungen Die erl{\"a}uterten praktischen Beispiele zeigen die Notwendigkeit, die Grundlagen der Statistik zu verstehen und korrekt anwenden zu k{\"o}nnen. Fehlendes Grundlagenwissen und Halbwissen der medizinischen Statistik k{\"o}nnen zu folgenschweren Missverst{\"a}ndnissen und falschen Entscheidungen in der medizinischen Forschung, aber auch in der klinischen Praxis f{\"u}hren.}, language = {de} } @inproceedings{BhattaraiFrotscherStaat2016, author = {Bhattarai, Aroj and Frotscher, Ralf and Staat, Manfred}, title = {Significance of fibre geometry on passive-active response of pelvic muscles to evaluate pelvic dysfunction}, series = {BioMedWomen: Proceedings of the international conference on clinical and bioengineering for women's health}, booktitle = {BioMedWomen: Proceedings of the international conference on clinical and bioengineering for women's health}, editor = {Natal Jorge, Renato}, publisher = {CRC Press}, address = {Boca Raton}, isbn = {978-1-138-02910-1}, pages = {185 -- 188}, year = {2016}, language = {en} } @article{WagnerVornholtWerneretal.2016, author = {Wagner, Torsten and Vornholt, Wolfgang and Werner, Frederik and Yoshinobu, Tatsuo and Miyamoto, Ko-Ichiro and Keusgen, Michael and Sch{\"o}ning, Michael Josef}, title = {Light-addressable potentiometric sensor (LAPS) combined with magnetic beads for pharmaceutical screening}, series = {Physics in medicine}, volume = {2016}, journal = {Physics in medicine}, number = {1}, issn = {2352-4510}, doi = {10.1016/j.phmed.2016.03.001}, pages = {2 -- 7}, year = {2016}, abstract = {The light-addressable potentiometric sensor (LAPS) has the unique feature to address different regions of a sensor surface without the need of complex structures. Measurements at different locations on the sensor surface can be performed in a common analyte solution, which distinctly simplifies the fluidic set-up. However, the measurement in a single analyte chamber prevents the application of different drugs or different concentrations of a drug to each measurement spot at the same time as in the case of multi-reservoir-based set-ups. In this work, the authors designed a LAPS-based set-up for cell culture screening that utilises magnetic beads loaded with the endotoxin (lipopolysaccharides, LPS), to generate a spatially distributed gradient of analyte concentration. Different external magnetic fields can be adjusted to move the magnetic beads loaded with a specific drug within the measurement cell. By recording the metabolic activities of a cell layer cultured on top of the LAPS surface, this work shows the possibility to apply different concentrations of a sample along the LAPS measurement spots within a common analyte solution.}, language = {en} } @article{DollWagnerWagneretal.2016, author = {Doll, Theodor and Wagner, Torsten and Wagner, Patrick and Sch{\"o}ning, Michael Josef}, title = {Engineering of functional interfaces / Theodor Doll ; Torsten Wagner ; Patrick Wagner ; Michael J. Sch{\"o}ning (eds.)}, series = {Physica status solidi (a)}, volume = {213}, journal = {Physica status solidi (a)}, number = {6}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1862-6319}, doi = {10.1002/pssa.201670641}, pages = {1393 -- 1394}, year = {2016}, language = {en} } @article{KnobeGiesenPlateetal.2016, author = {Knobe, M. and Giesen, M. and Plate, S. and Gradl-Dietsch, G. and Buecking, B. and Eschbach, D. and Laack, Walter van and Pape, H.-C.}, title = {The Aachen mobility and balance index to measure physiological falls risk: a comparison with the Tinetti POMA scale}, series = {European Journal Of Trauma And Emergency Surgery}, volume = {42}, journal = {European Journal Of Trauma And Emergency Surgery}, number = {5}, publisher = {Springer}, address = {Berlin}, issn = {1863-9941}, doi = {10.1007/s00068-016-0693-2}, pages = {537 -- 545}, year = {2016}, abstract = {Purpose The most commonly used mobility assessments for screening risk of falls among older adults are rating scales such as the Tinetti performance oriented mobility assessment (POMA). However, its correlation with falls is not always predictable and disadvantages of the scale include difficulty to assess many of the items on a 3-point scale and poor specificity. The purpose of this study was to describe the ability of the new Aachen Mobility and Balance Index (AMBI) to discriminate between subjects with a fall history and subjects without such events in comparison to the Tinetti POMA Scale. Methods For this prospective cohort study, 24 participants in the study group and 10 in the control group were selected from a population of patients in our hospital who had met the stringent inclusion criteria. Both groups completed the Tinetti POMA Scale (gait and balance component) and the AMBI (tandem stance, tandem walk, ten-meter-walk-test, sit-to-stand with five repetitions, 360° turns, timed-up-and-go-test and measurement of the dominant hand grip strength). A history of falls and hospitalization in the past year were evaluated retrospectively. The relationships among the mobility tests were examined with Bland-Altmananalysis. Receiver-operated characteristics curves, sensitivity and specificity were calculated. Results The study showed a strong negative correlation between the AMBI (17 points max., highest fall risk) and Tinetti POMA Scale (28 points max., lowest fall risk; r = -0.78, p < 0.001) with an excellent discrimination between community-dwelling older people and a younger control group. However, there were no differences in any of the mobility and balance measurements between participants with and without a fall history with equal characteristics in test comparison (AMBI vs. Tinetti POMA Scale: AUC 0.570 vs. 0.598; p = 0.762). The Tinetti POMA Scale (cut-off <20 points) showed a sensitivity of 0.45 and a specificity of 0.69, the AMBI a sensitivity of 0.64 and a specificity of 0.46 (cut-off >5 points). Conclusion The AMBI comprises mobility and balance tasks with increasing difficulty as well as a measurement of the dominant hand-grip strength. Its ability to identify fallers was comparable to the Tinetti POMA Scale. However, both measurement sets showed shortcomings in discrimination between fallers and non-fallers based on a self-reported retrospective falls-status.}, language = {en} } @article{MolinnusSorichBartzetal.2016, author = {Molinnus, Denise and Sorich, Maren and Bartz, Alexander and Siegert, Petra and Willenberg, Holger S. and Lisdat, Fred and Poghossian, Arshak and Keusgen, Michael and Sch{\"o}ning, Michael Josef}, title = {Towards an adrenaline biosensor based on substrate recycling amplification in combination with an enzyme logic gate}, series = {Sensors and Actuators B: Chemical}, volume = {237}, journal = {Sensors and Actuators B: Chemical}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0925-4005}, doi = {10.1016/j.snb.2016.06.064}, pages = {190 -- 195}, year = {2016}, abstract = {An amperometric biosensor using a substrate recycling principle was realized for the detection of low adrenaline concentrations (1 nM) by measurements in phosphate buffer and Ringer's solution at pH 6.5 and pH 7.4, respectively. In proof-of-concept experiments, a Boolean logic-gate principle has been applied to develop a digital adrenaline biosensor based on an enzyme AND logic gate. The obtained results demonstrate that the developed digital biosensor is capable for a rapid qualitative determination of the presence/absence of adrenaline in a YES/NO statement. Such digital biosensor could be used in clinical diagnostics for the control of a correct insertion of a catheter in the adrenal veins during adrenal venous-sampling procedure.}, language = {en} } @article{BelavyAlbrachtBruggemannetal.2016, author = {Belavy, Daniel L. and Albracht, Kirsten and Bruggemann, Gert-Peter and Vergroesen, Pieter-Paul A. and Dieen, Jaap H. van}, title = {Can exercise positively influence the intervertebral disc?}, series = {Sports Medicine}, volume = {46}, journal = {Sports Medicine}, number = {4}, publisher = {Springer}, address = {Berlin}, issn = {1179-2035}, doi = {10.1007/s40279-015-0444-2}, pages = {473 -- 485}, year = {2016}, abstract = {To better understand what kinds of sports and exercise could be beneficial for the intervertebral disc (IVD), we performed a review to synthesise the literature on IVD adaptation with loading and exercise. The state of the literature did not permit a systematic review; therefore, we performed a narrative review. The majority of the available data come from cell or whole-disc loading models and animal exercise models. However, some studies have examined the impact of specific sports on IVD degeneration in humans and acute exercise on disc size. Based on the data available in the literature, loading types that are likely beneficial to the IVD are dynamic, axial, at slow to moderate movement speeds, and of a magnitude experienced in walking and jogging. Static loading, torsional loading, flexion with compression, rapid loading, high-impact loading and explosive tasks are likely detrimental for the IVD. Reduced physical activity and disuse appear to be detrimental for the IVD. We also consider the impact of genetics and the likelihood of a 'critical period' for the effect of exercise in IVD development. The current review summarises the literature to increase awareness amongst exercise, rehabilitation and ergonomic professionals regarding IVD health and provides recommendations on future directions in research.}, language = {en} } @article{MiyamotoSatoAbeetal.2016, author = {Miyamoto, Ko-Ichiro and Sato, Takuya and Abe, Minami and Wagner, Torsten and Sch{\"o}ning, Michael Josef and Yoshinobu, Tatsuo}, title = {Light-addressable potentiometric sensor as a sensing element in plug-based microfluidic devices}, series = {Micromachines}, volume = {7}, journal = {Micromachines}, number = {7}, publisher = {MDPI}, address = {Basel}, issn = {2072-666X}, doi = {10.3390/mi7070111}, pages = {111}, year = {2016}, abstract = {A plug-based microfluidic system based on the principle of the light-addressable potentiometric sensor (LAPS) is proposed. The LAPS is a semiconductor-based chemical sensor, which has a free addressability of the measurement point on the sensing surface. By combining a microfluidic device and LAPS, ion sensing can be performed anywhere inside the microfluidic channel. In this study, the sample solution to be measured was introduced into the channel in a form of a plug with a volume in the range of microliters. Taking advantage of the light-addressability, the position of the plug could be monitored and pneumatically controlled. With the developed system, the pH value of a plug with a volume down to 400 nL could be measured. As an example of plug-based operation, two plugs were merged in the channel, and the pH change was detected by differential measurement.}, language = {en} } @inproceedings{KolditzAlbinAlbrachtetal.2016, author = {Kolditz, Melanie and Albin, Thivaharan and Albracht, Kirsten and Br{\"u}ggemann, Gert-Peter and Abel, Dirk}, title = {Isokinematic leg extension training with an industrial robot}, series = {6th IEEE RAS/EMBS International Conference on Biomedical Robotics and Biomechatronics (BioRob) June 26-29, 2016. UTown, Singapore}, booktitle = {6th IEEE RAS/EMBS International Conference on Biomedical Robotics and Biomechatronics (BioRob) June 26-29, 2016. UTown, Singapore}, doi = {10.1109/BIOROB.2016.7523750}, pages = {950 -- 955}, year = {2016}, language = {de} }