@article{GaribaldiBegingCaneseetal.2017, author = {Garibaldi, F. and Beging, Stefan and Canese, R. and Carpinelli, G. and Clinthorne, N. and Colilli, S. and Cosentino, L. and Finocchiaro, P. and Giuliani, F. and Gricia, M. and Lucentini, M. and Majewski, S. and Monno, E. and Musico, P. and Santavenere, F. and T{\"o}dter, J. and Wegener, Hans-Peter and Ziemons, Karl}, title = {A novel TOF-PET MRI detector for diagnosis and follow up of the prostate cancer}, series = {European Physical Journal Plus}, volume = {132}, journal = {European Physical Journal Plus}, number = {9}, publisher = {Springer}, address = {Berlin}, issn = {2190-5444}, doi = {10.1140/epjp/i2017-11662-x}, year = {2017}, language = {en} } @article{MiyamotoSekiSutoetal.2018, author = {Miyamoto, Koichiro and Seki, Kosuke and Suto, Takeyuki and Werner, Frederik and Wagner, Torsten and Sch{\"o}ning, Michael Josef and Yoshinobu, Tatsuo}, title = {Improved spatial resolution of the chemical imaging sensor with a hybrid illumination that suppresses lateral diffusion of photocarriers}, series = {Sensor and Actuators B: Chemical}, volume = {273}, journal = {Sensor and Actuators B: Chemical}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0925-4005}, doi = {10.1016/j.snb.2018.07.016}, pages = {1328 -- 1333}, year = {2018}, abstract = {The chemical imaging sensor is a semiconductor-based chemical sensor capable of visualizing pH and ion distributions. The spatial resolution depends on the lateral diffusion of photocarriers generated by illumination of the semiconductor substrate. In this study, two types of optical setups, one based on a bundle of optical fibers and the other based on a binocular tube head, were developed to project a hybrid illumination of a modulated light beam and a ring-shaped constant illumination onto the sensor plate. An improved spatial resolution was realized by the ring-shaped constant illumination, which suppressed lateral diffusion of photocarriers by enhanced recombination due to the increased carrier concentration.}, language = {en} } @article{LapitanRogatkinPersheyevetal.2018, author = {Lapitan, Denis G. and Rogatkin, Dmitrii A. and Persheyev, Sydulla K. and Kotliar, Konstantin}, title = {False spectra formation in the differential two-channel scheme of the laser Doppler flowmeter}, series = {Biomedizinische Technik}, volume = {63}, journal = {Biomedizinische Technik}, number = {4}, publisher = {De Gruyter}, address = {Berlin}, issn = {0013-5585}, doi = {10.1515/bmt-2017-0060}, pages = {439 -- 444}, year = {2018}, abstract = {Noise in the differential two-channel scheme of a classic laser Doppler flowmetry (LDF) instrument was studied. Formation of false spectral components in the output signal due to beating of electrical signals in the differential amplifier was found out. The improved block-diagram of the flowmeter was developed allowing to reduce the noise.}, language = {en} } @article{RoehlenPilasDahmenetal.2018, author = {R{\"o}hlen, Desiree and Pilas, Johanna and Dahmen, Markus and Keusgen, Michael and Selmer, Thorsten and Sch{\"o}ning, Michael Josef}, title = {Toward a Hybrid Biosensor System for Analysis of Organic and Volatile Fatty Acids in Fermentation Processes}, series = {Frontiers in Chemistry}, journal = {Frontiers in Chemistry}, number = {6}, publisher = {Frontiers}, address = {Lausanne}, doi = {10.3389/fchem.2018.00284}, pages = {Artikel 284}, year = {2018}, abstract = {Monitoring of organic acids (OA) and volatile fatty acids (VFA) is crucial for the control of anaerobic digestion. In case of unstable process conditions, an accumulation of these intermediates occurs. In the present work, two different enzyme-based biosensor arrays are combined and presented for facile electrochemical determination of several process-relevant analytes. Each biosensor utilizes a platinum sensor chip (14 × 14 mm²) with five individual working electrodes. The OA biosensor enables simultaneous measurement of ethanol, formate, d- and l-lactate, based on a bi-enzymatic detection principle. The second VFA biosensor provides an amperometric platform for quantification of acetate and propionate, mediated by oxidation of hydrogen peroxide. The cross-sensitivity of both biosensors toward potential interferents, typically present in fermentation samples, was investigated. The potential for practical application in complex media was successfully demonstrated in spiked sludge samples collected from three different biogas plants. Thereby, the results obtained by both of the biosensors were in good agreement to the applied reference measurements by photometry and gas chromatography, respectively. The proposed hybrid biosensor system was also used for long-term monitoring of a lab-scale biogas reactor (0.01 m³) for a period of 2 months. In combination with typically monitored parameters, such as gas quality, pH and FOS/TAC (volatile organic acids/total anorganic carbonate), the amperometric measurements of OA and VFA concentration could enhance the understanding of ongoing fermentation processes.}, language = {en} } @article{RodriguesMoraisNordietal.2018, author = {Rodrigues, Raul T. and Morais, Paulo V. and Nordi, Cristina S. F. and Sch{\"o}ning, Michael Josef and Siqueira Jr., Jos{\´e} R. and Caseli, Luciano}, title = {Carbon Nanotubes and Algal Polysaccharides To Enhance the Enzymatic Properties of Urease in Lipid Langmuir-Blodgett Films}, series = {Langmuir}, volume = {34}, journal = {Langmuir}, number = {9}, publisher = {ACS Publications}, address = {Washington, DC}, issn = {1520-5827}, doi = {10.1021/acs.langmuir.7b04317}, pages = {3082 -- 3093}, year = {2018}, abstract = {Algal polysaccharides (extracellular polysaccharides) and carbon nanotubes (CNTs) were adsorbed on dioctadecyldimethylammonium bromide Langmuir monolayers to serve as a matrix for the incorporation of urease. The physicochemical properties of the supramolecular system as a monolayer at the air-water interface were investigated by surface pressure-area isotherms, surface potential-area isotherms, interfacial shear rheology, vibrational spectroscopy, and Brewster angle microscopy. The floating monolayers were transferred to hydrophilic solid supports, quartz, mica, or capacitive electrolyte-insulator-semiconductor (EIS) devices, through the Langmuir-Blodgett (LB) technique, forming mixed films, which were investigated by quartz crystal microbalance, fluorescence spectroscopy, and field emission gun scanning electron microscopy. The enzyme activity was studied with UV-vis spectroscopy, and the feasibility of the thin film as a urea sensor was essayed in an EIS sensor device. The presence of CNT in the enzyme-lipid LB film not only tuned the catalytic activity of urease but also helped to conserve its enzyme activity. Viability as a urease sensor was demonstrated with capacitance-voltage and constant capacitance measurements, exhibiting regular and distinctive output signals over all concentrations used in this work. These results are related to the synergism between the compounds on the active layer, leading to a surface morphology that allowed fast analyte diffusion owing to an adequate molecular accommodation, which also preserved the urease activity. This work demonstrates the feasibility of employing LB films composed of lipids, CNT, algal polysaccharides, and enzymes as EIS devices for biosensing applications.}, language = {en} } @article{AlbannaKotliarLuekeetal.2018, author = {Albanna, Walid and Kotliar, Konstantin and L{\"u}ke, Jan Niklas and Alpdogan, Serdar and Conzen, Catharina and Lindauer, Ute and Clusmann, Hans and Hescheler, J{\"u}rgen and Vilser, Walthard and Schneider, Toni and Schubert, Gerrit Alexander}, title = {Non-invasive evaluation of neurovascular coupling in the murine retina by dynamic retinal vessel analysis}, series = {Plos one}, volume = {13}, journal = {Plos one}, number = {10}, publisher = {PLOS}, address = {San Francisco}, doi = {10.1371/journal.pone.0204689}, pages = {e0204689}, year = {2018}, abstract = {Background Impairment of neurovascular coupling (NVC) was recently reported in the context of subarachnoid hemorrhage and may correlate with disease severity and outcome. However, previous techniques to evaluate NVC required invasive procedures. Retinal vessels may represent an alternative option for non-invasive assessment of NVC. Methods A prototype of an adapted retinal vessel analyzer was used to assess retinal vessel diameter in mice. Dynamic vessel analysis (DVA) included an application of monochromatic flicker light impulses in predefined frequencies for evaluating NVC. All retinae were harvested after DVA and electroretinograms were performed. Results A total of 104 retinal scans were conducted in 21 male mice (90 scans). Quantitative arterial recordings were feasible only in a minority of animals, showing an emphasized reaction to flicker light impulses (8 mice; 14 scans). A characteristic venous response to flicker light, however, could observed in the majority of animals. Repeated measurements resulted in a significant decrease of baseline venous diameter (7 mice; 7 scans, p < 0.05). Ex-vivo electroretinograms, performed after in-vivo DVA, demonstrated a significant reduction of transretinal signaling in animals with repeated DVA (n = 6, p < 0.001). Conclusions To the best of our knowledge, this is the first non-invasive study assessing murine retinal vessel response to flicker light with characteristic changes in NVC. The imaging system can be used for basic research and enables the investigation of retinal vessel dimension and function in control mice and genetically modified animals.}, language = {en} } @article{BalakirskiKotliarPaulyetal.2018, author = {Balakirski, Galina and Kotliar, Konstantin and Pauly, Karolin J. and Krings, Laura K. and R{\"u}bben, Albert and Baron, Jens M. and Schmitt, Laurenz}, title = {Surgical Site Infections After Dermatologic Surgery in Immunocompromised Patients: A Single-Center Experience}, series = {Dermatologic Surgery}, journal = {Dermatologic Surgery}, number = {44 (12)}, publisher = {Wolters Kluwer}, doi = {10.1097/DSS.0000000000001615}, pages = {1525 -- 1536}, year = {2018}, abstract = {BACKGROUND Immunosuppression is often considered as an indication for antibiotic prophylaxis to prevent surgical site infections (SSI) while performing skin surgery. However, the data on the risk of developing SSI after dermatologic surgery in immunosuppressed patients are limited. PATIENTS AND METHODS All patients of the Department of Dermatology and Allergology at the University Hospital of RWTH Aachen in Aachen, Germany, who underwent hospitalization for a dermatologic surgery between June 2016 and January 2017 (6 months), were followed up after surgery until completion of the wound healing process. The follow-up addressed the occurrence of SSI and the need for systemic antibiotics after the operative procedure. Immunocompromised patients were compared with immunocompetent patients. The investigation was conducted as a retrospective analysis of patient records. RESULTS The authors performed 284 dermatologic surgeries in 177 patients. Nineteen percent (54/284) of the skin surgery was performed on immunocompromised patients. The most common indications for surgical treatment were nonmelanoma skin cancer and malignant melanomas. Surgical site infections occurred in 6.7\% (19/284) of the cases. In 95\% (18/19), systemic antibiotic treatment was needed. Twenty-one percent of all SSI (4/19) were seen in immunosuppressed patients. CONCLUSION According to the authors' data, immunosuppression does not represent a significant risk factor for SSI after dermatologic surgery. However, larger prospective studies are needed to make specific recommendations on the use of antibiotic prophylaxis while performing skin surgery in these patients. The available data on complications after dermatologic surgery have improved over the past years. Particularly, additional risk factors have been identified for surgical site infections (SSI). Purulent surgical sites, older age, involvement of head, neck, and acral regions, and also the involvement of less experienced surgeons have been reported to increase the risk of the SSI after dermatologic surgeries.1 In general, the incidence of SSI after skin surgery is considered to be low.1,2 However, antibiotics in dermatologic surgeries, especially in the perioperative setting, seem to be overused,3,4 particularly regarding developing antibiotic resistances and side effects. Immunosuppression has been recommended to be taken into consideration as an additional indication for antibiotic prophylaxis to prevent SSI after skin surgery in special cases.5,6 However, these recommendations do not specify the exact dermatologic surgeries, and were not specifically developed for dermatologic surgery patients and treatments, but adopted from other surgical fields.6 According to the survey conducted on American College of Mohs Surgery members in 2012, 13\% to 29\% of the surgeons administered antibiotic prophylaxis to immunocompromised patients to prevent SSI while performing dermatologic surgery on noninfected skin,3 although this was not recommended by Journal of the American Academy of Dermatology Advisory Statement. Indeed, the data on the risk of developing SSI after dermatologic surgery in immunosuppressed patients are limited. However, it is possible that due to the insufficient evidence on the risk of SSI occurrence in this patient group, dermatologic surgeons tend to overuse perioperative antibiotic prophylaxis. To make specific recommendations on the use of antibiotic prophylaxis in immunosuppressed patients in the field of skin surgery, more information about the incidence of SSI after dermatologic surgery in these patients is needed. The aim of this study was to fill this data gap by investigating whether there is an increased risk of SSI after skin surgery in immunocompromised patients compared with immunocompetent patients.}, language = {en} } @article{RittwegerAlbrachtFluecketal.2018, author = {Rittweger, J{\"o}rn and Albracht, Kirsten and Fl{\"u}ck, Martin and Ruoss, Severin and Brocca, Lorenza and Longa, Emanuela and Moriggi, Manuela and Seynnes, Olivier and Di Giulio, Irene and Tenori, Leonardo and Vignoli, Alessia and Capri, Miriam and Gelfi, Cecilia and Luchinat, Claudio and Franceschi, Claudio and Bottinelli, Roberto and Cerretelli, Paolo and Narici, Marco}, title = {Sarcolab pilot study into skeletal muscle's adaptation to longterm spaceflight}, series = {npj Microgravity}, volume = {4}, journal = {npj Microgravity}, number = {1}, publisher = {Nature Portfolio}, issn = {2373-8065}, doi = {10.1038/s41526-018-0052-1}, pages = {1 -- 9}, year = {2018}, language = {en} } @article{WerkhausenCroninAlbrachtetal.2019, author = {Werkhausen, Amelie and Cronin, Neil J. and Albracht, Kirsten and Bojsen-M{\o}ller, Jens and Seynnes, Olivier R.}, title = {Distinct muscle-tendon interaction during running at different speeds and in different loading conditions}, series = {Journal of Applied Physiology}, volume = {127}, journal = {Journal of Applied Physiology}, number = {1}, issn = {1522-1601}, doi = {10.1152/japplphysiol.00710.2018}, pages = {246 -- 253}, year = {2019}, language = {en} } @article{ErmolaevErichevAntonovetal.2019, author = {Ermolaev, AP and Erichev, VP and Antonov, AA and Grigoryan, GL and Kotliar, Konstantin and Levitsky, YV and Hderi, K and Mazurova, YV}, title = {Assessing retinal photosensitivity in patients with central vision impairment using a portable perimeter (a preliminary report)}, series = {Vestnik oftalmologii}, volume = {135}, journal = {Vestnik oftalmologii}, number = {3}, doi = {10.17116/oftalma201913503146}, pages = {46 -- 54}, year = {2019}, language = {ru} } @article{JildehKirchnerBaltesetal.2019, author = {Jildeh, Zaid B. and Kirchner, Patrick and Baltes, Klaus and Wagner, Patrick H. and Sch{\"o}ning, Michael Josef}, title = {Development of an in-line evaporation unit for the production of gas mixtures containing hydrogen peroxide - numerical modeling and experimental results}, series = {International Journal of Heat and Mass Transfer}, volume = {143}, journal = {International Journal of Heat and Mass Transfer}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0017-9310}, doi = {10.1016/j.ijheatmasstransfer.2019.118519}, pages = {Article number 118519}, year = {2019}, abstract = {Hydrogen peroxide (H2O2) is a typical surface sterilization agent for packaging materials used in the pharmaceutical, food and beverage industries. We use the finite-elements method to analyze the conceptual design of an in-line thermal evaporation unit to produce a heated gas mixture of air and evaporated H2O2 solution. For the numerical model, the required phase-transition variables of pure H2O2 solution and of the aerosol mixture are acquired from vapor-liquid equilibrium (VLE) diagrams derived from vapor-pressure formulations. This work combines homogeneous single-phase turbulent flow with heat-transfer physics to describe the operation of the evaporation unit. We introduce the apparent heat-capacity concept to approximate the non-isothermal phase-transition process of the H2O2-containing aerosol. Empirical and analytical functions are defined to represent the temperature- and pressure-dependent material properties of the aqueous H2O2 solution, the aerosol and the gas mixture. To validate the numerical model, the simulation results are compared to experimental data on the heating power required to produce the gas mixture. This shows good agreement with the deviations below 10\%. Experimental observations on the formation of deposits due to the evaporation of stabilized H2O2 solution fits the prediction made from simulation results.}, language = {en} } @article{ErmolaevNivokovMelnikovaetal.2018, author = {Ermolaev, A.P. and Nivokov, I.A. and Melnikova, L.I. and Kotliar, Konstantin}, title = {Сравнительная характеристика химического состава витреального содержимого кадаверных глаз и глаз с рефрактерной терминальной глаукомой}, series = {Vestnik oftalmologii}, volume = {5}, journal = {Vestnik oftalmologii}, number = {2}, publisher = {Media Sfera}, address = {Moskau}, doi = {10.17116/oftalma2018134051195}, pages = {195 -- 201}, year = {2018}, abstract = {Purpose — to compare the chemical elemental composition of vitreous cavity content taken from cadaveric eyes compared to samples taken from the eyes with terminal stage refractory glaucoma with decompensated intraocular pressure (IOP). Material and methods. The vitreous contents of the eyes from 2 groups were studied. The 1st group included 15 cadaveric eyes; the 2nd group included 15 eyes with refractory glaucoma in the terminal stage of the disease with decompensated IOP in patients with hypertension pain. The vitreal content samples were taken in the course of antiglaucoma surgery aimed at preserving the eye as an organ and involving employment of drainage in the vitreous cavity. The study of virtual contents was carried out on energy dispersive spectrometer Oxford X-Max 50 integrated into scanning electron microscope Zeiss EVO LS10. Results. Increased concentrations of Kalium and Phosphorus were detected in the vitreous content of cadaveric eyes compared with the vitreal content from the eyes with terminal glaucoma with decompensated IOP taken in vivo (K — 0.172/0.093; P — 0.045/0.025 mmol/L). In the vitreous cavity in the eyes with end-stage glaucoma with decompensated IOP, the concentration of Nitrogen was higher in comparison with human cadaver eyes (2.030/1.424 mmol/L). Conclusion. The increased concentrations of Kalium and Phosphorus in the vitreous content of cadaveric eyes is associated with postmortem autolytic processes and with the release of intracellular content in the destruction of cell membranes. The increased Nitrogen concentration in the vitreal contents of the eyes with terminal stage glaucoma with decompensated IOP may be associated with the presence of osmotically active nitrogen-containing compounds in the eyes with increased IOP.}, language = {ru} } @article{CapriMorsianiSantoroetal.2019, author = {Capri, Miriam and Morsiani, Cristina and Santoro, Aurelia and Moriggi, Manuela and Conte, Maria and Martucci, Morena and Bellavista, Elena and Fabbri, Cristina and Giampieri, Enrico and Albracht, Kirsten and Fl{\"u}ck, Martin and Ruoss, Severin and Brocca, Lorenza and Canepari, Monica and Longa, Emanuela and Giulio, Irene Di and Bottinelli, Roberto and Cerretelli, Paolo and Salvioli, Stefano and Gelfi, Cecilia and Franceschi, Claudio and Narici, Marco and Rittweger, J{\"o}rn}, title = {Recovery from 6-month spaceflight at the International Space Station: muscle-related stress into a proinflammatory setting}, series = {The FASEB journal : official publication of the Federation of American Societies for Experimental Biology}, volume = {33}, journal = {The FASEB journal : official publication of the Federation of American Societies for Experimental Biology}, number = {4}, doi = {10.1096/fj.201801625R}, pages = {5168 -- 5180}, year = {2019}, language = {en} } @article{QuittmannAbelAlbrachtetal.2019, author = {Quittmann, Oliver J. and Abel, Thomas and Albracht, Kirsten and Str{\"u}der, Heiko K.}, title = {Reliability of muscular activation patterns and their alterations during incremental handcycling in able-bodied participants}, series = {Sports Biomechanics}, journal = {Sports Biomechanics}, number = {Article in press}, publisher = {Taylor \& Francis}, address = {London}, issn = {1752-6116}, doi = {10.1080/14763141.2019.1593496}, year = {2019}, language = {en} } @article{KoppSchmeetsGosauetal.2019, author = {Kopp, Alexander and Schmeets, Ralf and Gosau, Martin and Friedrich, Reinhard E. and Fuest, Sandra and Behbahani, Mehdi and Barbeck, Mike and Rutkowski, Rico and Burg, Simon and Kluwe, Lan and Henningsen, Anders}, title = {Production and Characterization of Porous Fibroin Scaffolds for Regenerative Medical Application}, series = {In Vivo}, volume = {33}, journal = {In Vivo}, number = {3}, issn = {1791-7549}, doi = {10.21873/invivo.11536}, pages = {757 -- 762}, year = {2019}, language = {en} } @inproceedings{SiebigterothKraftSchmidtsetal.2019, author = {Siebigteroth, Ines and Kraft, Bodo and Schmidts, Oliver and Z{\"u}ndorf, Albert}, title = {A Study on Improving Corpus Creation by Pair Annotation}, series = {Proceedings of the Poster Session of the 2nd Conference on Language, Data and Knowledge (LDK-PS 2019)}, booktitle = {Proceedings of the Poster Session of the 2nd Conference on Language, Data and Knowledge (LDK-PS 2019)}, issn = {1613-0073}, pages = {40 -- 44}, year = {2019}, language = {en} } @article{KodomskoiKotliarSchroederetal.2019, author = {Kodomskoi, Leonid and Kotliar, Konstantin and Schr{\"o}der, Andreas and Weiss, Michael and Hille, Konrad}, title = {Suture-Probe Canaloplasty as an Alternative to Canaloplasty using the iTrack™ Microcatheter}, series = {Journal of Glaucoma}, journal = {Journal of Glaucoma}, number = {Epub ahead of print}, publisher = {Lippincott Williams \& Wilkins}, address = {Philadelphia}, issn = {1057-0829}, doi = {10.1097/IJG.0000000000001321}, year = {2019}, language = {en} } @article{GerhardsSanderZivkovicetal.2020, author = {Gerhards, Michael and Sander, Volker and Zivkovic, Miroslav and Belloum, Adam and Bubak, Marian}, title = {New approach to allocation planning of many-task workflows on clouds}, series = {Concurrency and Computation: Practice and Experience}, volume = {32}, journal = {Concurrency and Computation: Practice and Experience}, number = {2 Article e5404}, publisher = {Wiley}, address = {Chichester}, issn = {1532-0634}, doi = {10.1002/cpe.5404}, pages = {1 -- 16}, year = {2020}, abstract = {Experience has shown that a priori created static resource allocation plans are vulnerable to runtime deviations and hence often become uneconomic or highly exceed a predefined soft deadline. The assumption of constant task execution times during allocation planning is even more unlikely in a cloud environment where virtualized resources vary in performance. Revising the initially created resource allocation plan at runtime allows the scheduler to react on deviations between planning and execution. Such an adaptive rescheduling of a many-task application workflow is only feasible, when the planning time can be handled efficiently at runtime. In this paper, we present the static low-complexity resource allocation planning algorithm (LCP) applicable to efficiently schedule many-task scientific application workflows on cloud resources of different capabilities. The benefits of the presented algorithm are benchmarked against alternative approaches. The benchmark results show that LCP is not only able to compete against higher complexity algorithms in terms of planned costs and planned makespan but also outperforms them significantly by magnitudes of 2 to 160 in terms of required planning time. Hence, LCP is superior in terms of practical usability where low planning time is essential such as in our targeted online rescheduling scenario.}, language = {en} } @article{DantismRoehlenSelmeretal.2019, author = {Dantism, Shahriar and R{\"o}hlen, Desiree and Selmer, Thorsten and Wagner, Torsten and Wagner, Patrick and Sch{\"o}ning, Michael Josef}, title = {Quantitative differential monitoring of the metabolic activity of Corynebacterium glutamicum cultures utilizing a light-addressable potentiometric sensor system}, series = {Biosensors and Bioelectronics}, volume = {139}, journal = {Biosensors and Bioelectronics}, publisher = {Elsevier}, address = {Amsterdam}, doi = {10.1016/j.bios.2019.111332}, pages = {Artikel 111332}, year = {2019}, language = {en} } @phdthesis{Geenen2013, author = {Geenen, Eva-Maria}, title = {Studies of Epstein-Barr virus EBNA2 and its interactions with host cell factors}, publisher = {Universit{\´e} de Grenoble}, address = {Grenoble}, pages = {125 S.}, year = {2013}, language = {en} }