@article{LeursMezoOehlschlaegeretal.2012,
  author    = {Leurs, Ulrike and Mezo, Gabor and {\"O}hlschl{\"a}ger, Peter and Orban, Erika and Marquard, Andrea and Manea, Marilena},
  title     = {Design, synthesis, in vitro stability and cytostatic effect of multifunctional anticancer drug-bioconjugates containing GnRH-III as a targeting moiety},
  series = {Peptide Science},
  volume    = {98},
  journal   = {Peptide Science},
  number    = {1},
  publisher = {Wiley},
  address   = {New York, NY},
  issn      = {1097-0282},
  doi       = {10.1002/bip.21640},
  pages     = {1 -- 10},
  year      = {2012},
  abstract  = {Bioconjugates containing the GnRH-III hormone decapeptide as a targeting moiety are able to deliver chemotherapeutic agents specifically to cancer cells expressing GnRH receptors, thereby increasing their local efficacy while limiting the peripheral toxicity. However, the number of GnRH receptors on cancer cells is limited and they desensitize under continuous hormone treatment. A possible approach to increase the receptor mediated tumor targeting and consequently the cytostatic effect of the bioconjugates would be the attachment of more than one chemotherapeutic agent to one GnRH-III molecule. Here we report on the design, synthesis and biochemical characterization of multifunctional bioconjugates containing GnRH-III as a targeting moiety and daunorubicin as a chemotherapeutic agent. Two different drug design approaches were pursued. The first one was based on the bifunctional [4Lys]-GnRH-III (Glp-His-Trp-Lys-His-Asp-Trp-Lys-Pro-Gly-NH2) containing two lysine residues in positions 4 and 8, whose ϵ-amino groups were used for the coupling of daunorubicin. In the second drug design, the native GnRH-III (Glp-His-Trp-Ser-His-Asp-Trp-Lys-Pro-Gly-NH2) was used as a scaffold; an additional lysine residue was coupled to the ϵ-amino group of 8Lys in order to generate two free amino groups available for conjugation of daunorubicin. The in vitro stability/degradation of all synthesized compounds was investigated in human serum, as well as in the presence of rat liver lysosomal homogenate. Their cellular uptake was determined on human breast cancer cells and the cytostatic effect was evaluated on human breast, colon and prostate cancer cell lines. Compared with a monofunctional compound, both drug design approaches resulted in multifunctional bioconjugates with increased cytostatic effect.},
  language  = {en}
}
@article{ManeaLeursOrbanetal.2011,
  author    = {Manea, Marilena and Leurs, Ulrike and Orban, Erika and Baranyai, Zsuzsa and {\"O}hlschl{\"a}ger, Peter and Marquardt, Andreas and Schulcz, Akos and Tejeda, Miguel},
  title     = {Enhanced Enzymatic Stability and Antitumor Activity of Daunorubicin-GnRH-III Bioconjugates Modified in Position 4},
  series = {Bioconjugate Chemistry},
  volume    = {22},
  journal   = {Bioconjugate Chemistry},
  number    = {7},
  publisher = {ACS},
  address   = {Washington, DC},
  isbn      = {1520-4812},
  pages     = {1320 -- 1329},
  year      = {2011},
  language  = {en}
}
@article{SpiessWilfriedAlvarezetal.2011,
  author    = {Spiess, Elmar and Wilfried, Reichardt and Alvarez, Gerardo and Gottrup, Marcus and {\"O}hlschl{\"a}ger, Peter},
  title     = {An Artificial PAP Gene Breaks Self-tolerance and Promotes Tumor Regression in the TRAMP Model for Prostate Carcinoma},
  series = {Molecular Therapy},
  volume    = {20},
  journal   = {Molecular Therapy},
  number    = {3},
  publisher = {Elsevier},
  address   = {Amsterdam},
  isbn      = {1525-0016},
  pages     = {555 -- 564},
  year      = {2011},
  language  = {en}
}
@article{SchiffelsPinkenburgScheldenetal.2013,
  author    = {Schiffels, Johannes and Pinkenburg, Olaf and Schelden, Maximilian and Aboulnaga, El-Hussiny A. A. and Baumann, Marcus and Selmer, Thorsten},
  title     = {An innovative cloning platform enables large-scale production and maturation of an oxygen-tolerant [NiFe]-hydrogenase from cupriavidus necator in Escherichia coli},
  series = {PLOS one. 2013},
  journal   = {PLOS one. 2013},
  publisher = {Public Library of Science},
  address   = {San Francisco, California},
  issn      = {1932-6203},
  doi       = {10.1371/journal.pone.0068812},
  year      = {2013},
  language  = {en}
}
@article{KotterHammon1986,
  author    = {Kotter, Michael and Hammon, U.},
  title     = {Preparation of pellets with well-defined pore structure / U. Hammon ; A. Kotter},
  series = {International chemical engineering. 26 (1986), H. 4},
  journal   = {International chemical engineering. 26 (1986), H. 4},
  isbn      = {0020-6318},
  pages     = {563 -- 573},
  year      = {1986},
  language  = {en}
}
@article{ElbersPfefferFrieseletal.1995,
  author    = {Elbers, Gereon and Pfeffer, Hans-Ulrich and Friesel, J{\"u}rgen and Beier, Reinhold},
  title     = {Air Pollution Monitoring in Street Canyons / Hans-Ulrich Pfeffer, J{\"u}rgen Friesel, Gereon Elbers, Reinhold Beier,},
  series = {Transport and air pollution : proceedings ; 3rd international symposium, Palais des Papes, Avignon, France, 6 - 10 June 1994 = Transports et pollution de l'air / [Third International Symposium on Transport and Air Pollution]. Ed. by Robert Joumard. Organizer: French National Institute for Transport and Safety Research},
  journal   = {Transport and air pollution : proceedings ; 3rd international symposium, Palais des Papes, Avignon, France, 6 - 10 June 1994 = Transports et pollution de l'air / [Third International Symposium on Transport and Air Pollution]. Ed. by Robert Joumard. Organizer: French National Institute for Transport and Safety Research},
  publisher = {Elsevier},
  address   = {Amsterdam},
  pages     = {IX, 337 S : graph. Darst.},
  year      = {1995},
  language  = {en}
}
@article{ElbersGaebHoffmannetal.2006,
  author    = {Elbers, Gereon and G{\"a}b, Martina and Hoffmann, Katharina and Lobe, Melanie},
  title     = {NIR-spectroscopic investigation of foliage of ozone-stressed Fagus sylvatica trees / G{\"a}b, Martina ; Hoffmann, Katharina ; Lobe, Melanie ; Metzger, Rut ; Ooyen, Sven van ; Elbers, Gereon ; K{\"o}llner, Barbara},
  series = {Journal of Forest Research. 11 (2006), H. 2},
  journal   = {Journal of Forest Research. 11 (2006), H. 2},
  isbn      = {1341-6979},
  pages     = {69 -- 75},
  year      = {2006},
  language  = {en}
}
@article{SchmichEdererEbert1992,
  author    = {Schmich, Peter and Ederer, Hanns J. and Ebert, Klaus H.},
  title     = {Detection and identification of free radicals in hydrocarbon pyrolysis by an iodine trapping method},
  series = {Industrial \& Engineering Chemistry Research. 31 (1992), H. 1},
  journal   = {Industrial \& Engineering Chemistry Research. 31 (1992), H. 1},
  isbn      = {1520-5045},
  pages     = {29 -- 37},
  year      = {1992},
  language  = {en}
}
@book{GilchRath1995,
  author    = {Gilch, Heinz Gerhard and Rath, Walter},
  title     = {Moisture-curing, polyurethane hot-melt compositions = Feuchtigkeitsh{\"a}rtende Polyurethan-Schmelzklebstoff-Zusammensetzungen},
  publisher = {Europ{\"a}isches Patentamt},
  address   = {M{\"u}nchen},
  year      = {1995},
  language  = {en}
}
@article{PrielmeierNagatomoWicketal.1995,
  author    = {Prielmeier, Franz and Nagatomo, Yasushi and Wick, Markus and Frahm, Jens},
  title     = {Dynamic monitoring of cerebral metabolites during and after transient global ischemia in rats by quantitative proton NMR spectroscopy in vivo / Yasushi Nagatomo, Markus Wick, Franz Prielmeier, Jens Frahm},
  series = {NMR in Biomedicine. 8 (1995), H. 6},
  journal   = {NMR in Biomedicine. 8 (1995), H. 6},
  isbn      = {1099-1492},
  pages     = {265 -- 270},
  year      = {1995},
  language  = {en}
}
@article{PrielmeierWickNagatomoetal.1995,
  author    = {Prielmeier, Franz and Wick, Markus and Nagatomo, Yasushi and Frahm, Jens},
  title     = {Alteration of Intracellular Metabolite Diffusion in Rat Brain In Vivo During Ischemia and Reperfusion / Markus Wick, Yasushi Nagatomo, Franz Prielmeier, Jens Frahm},
  series = {Stroke. 26 (1995), H. 10},
  journal   = {Stroke. 26 (1995), H. 10},
  isbn      = {0039-2499},
  pages     = {1930 -- 1934},
  year      = {1995},
  language  = {en}
}
@article{PrielmeierNagatomoFrahm1994,
  author    = {Prielmeier, Franz and Nagatomo, Yasushi and Frahm, Jens},
  title     = {Cerebral blood oxygenation in rat brain during hypoxic hypoxia. Quantitative MRI of effective transverse relaxation rates},
  series = {Magnetic Resonance in Medicine. 31 (1994), H. 6},
  journal   = {Magnetic Resonance in Medicine. 31 (1994), H. 6},
  isbn      = {0740-3194},
  pages     = {678 -- 681},
  year      = {1994},
  language  = {en}
}
@article{MerschenzQuackMootz1988,
  author    = {Merschenz-Quack, Angelika and Mootz, D.},
  title     = {Structures of sulfuryl halides: SO2F2, SO2CIF and SO2Cl2 / Mootz, D. ; Merschenz-Quack, A.},
  series = {Acta crystallographica / Section C, Crystal structure communications. C 44 (1988), H. 5},
  journal   = {Acta crystallographica / Section C, Crystal structure communications. C 44 (1988), H. 5},
  isbn      = {0108-2701},
  pages     = {924 -- 925},
  year      = {1988},
  language  = {en}
}
@article{MerschenzQuackMootz1990,
  author    = {Merschenz-Quack, Angelika and Mootz, D.},
  title     = {Structure of 5-sulfosalicylic acid pentahydrate},
  series = {Acta crystallographica / Section C, Crystal structure communications. C 46 (1990), H. 8},
  journal   = {Acta crystallographica / Section C, Crystal structure communications. C 46 (1990), H. 8},
  isbn      = {0108-2701},
  pages     = {1478 -- 1480},
  year      = {1990},
  language  = {en}
}
@article{Jeromin2001,
  author    = {Jeromin, G{\"u}nter Erich},
  title     = {Tetrabenzo[a,c,h,j]phenoxazine-18-yl a new stable neutral radical},
  series = {Tetrahedron Letters . 42 (2001), H. 10},
  journal   = {Tetrahedron Letters . 42 (2001), H. 10},
  isbn      = {0040-4039},
  pages     = {1863 -- 1865},
  year      = {2001},
  language  = {en}
}
@article{JerominWelsch1995,
  author    = {Jeromin, G{\"u}nter Erich and Welsch, Volker},
  title     = {Diketene a New Esterification Reagent in the Enzyme-Aided Synthesis of Chiral Alcohols and Chiral Acetoacetic Acid Esters},
  series = {Tetrahedron Letters . 36 (1995), H. 37},
  journal   = {Tetrahedron Letters . 36 (1995), H. 37},
  isbn      = {0040-4039},
  pages     = {6663 -- 6664},
  year      = {1995},
  language  = {en}
}
@article{JerominScheidt1991,
  author    = {Jeromin, G{\"u}nter Erich and Scheidt, Annette},
  title     = {Aliphatic optically active alcohols by enzyme-aided synthesis},
  series = {Tetrahedron Letters . 32 (1991), H. 48},
  journal   = {Tetrahedron Letters . 32 (1991), H. 48},
  isbn      = {0040-4039},
  pages     = {7021 -- 7024},
  year      = {1991},
  language  = {en}
}
@article{JerominAlbertz1992,
  author    = {Jeromin, G{\"u}nter Erich and Albertz, Michael},
  title     = {Optically active \&\#945;-acetoxycarboxylic acids and \&\#945;-hydroxycarboxylic acids by enzyme-aided syntheses},
  series = {Journal f{\"u}r Praktische Chemie / Chemiker-Zeitung. 334 (1992), H. 6},
  journal   = {Journal f{\"u}r Praktische Chemie / Chemiker-Zeitung. 334 (1992), H. 6},
  isbn      = {1436-9966},
  pages     = {526 -- 528},
  year      = {1992},
  language  = {en}
}
@article{PrielmeierMerboldtHanickeetal.1993,
  author    = {Prielmeier, Franz and Merboldt, K. D. and Hanicke, W. and Frahm, J.},
  title     = {Dynamic high-resolution MR imaging of brain deoxygenation during transient anoxia in the anesthetized rat},
  series = {Journal of cerebral blood flow and metabolism. 13 (1993), H. 5},
  journal   = {Journal of cerebral blood flow and metabolism. 13 (1993), H. 5},
  isbn      = {0271-678X},
  pages     = {889 -- 894},
  year      = {1993},
  language  = {en}
}
@article{PrielmeierHoerstermannGyngelletal.1992,
  author    = {Prielmeier, Franz and H{\"o}rstermann, D. and Gyngell, M. L. and Merboldt, K.-D.},
  title     = {Localized Proton MRS of Acute and Chronic Gyperglycemia in Rat Brain in vivo / D. H{\"o}rstermann, F. Prielmeier , M. L. Gyngell, K.-D. Merboldt, W. H{\"a}nicke, J. Frahm},
  series = {Book of Abstracts, SMRM, 11th Annual Meeting Berlin},
  journal   = {Book of Abstracts, SMRM, 11th Annual Meeting Berlin},
  pages     = {2740},
  year      = {1992},
  language  = {en}
}