@inproceedings{Klocke2012,
  author    = {Klocke, Martina},
  title     = {Projektmodul im Bachelorstudiengang Maschinenbau und Mechatronik},
  series = {VDI-Workshop Projektorientiertes und problem-basiertes Lernen (PBL) in der Ingenieurausbildung},
  booktitle = {VDI-Workshop Projektorientiertes und problem-basiertes Lernen (PBL) in der Ingenieurausbildung},
  pages     = {1 -- 25},
  year      = {2012},
  language  = {de}
}
@inproceedings{KnackstedtEggertFleischer2012,
  author    = {Knackstedt, Ralf and Eggert, Mathias and Fleischer, Stefan},
  title     = {The Legal Perspective on Business to Government Reporting - A Conceptual Modeling Approach and Its Application in the Financial Sector},
  series = {45th Hawaii International Conference on System Sciences 2012},
  booktitle = {45th Hawaii International Conference on System Sciences 2012},
  isbn      = {978-0-7695-4525-7},
  doi       = {10.1109/HICSS.2012.576},
  pages     = {2309 -- 2318},
  year      = {2012},
  language  = {en}
}
@article{Knueppel2012,
  author    = {Kn{\"u}ppel, Mark},
  title     = {Außerbilanzielle Korrekturen},
  series = {Handbuch der Bilanzierung online},
  journal   = {Handbuch der Bilanzierung online},
  editor    = {Federmann, Rudolf and Kußmaul, Heinz and M{\"u}ller, Stefan},
  publisher = {Haufe},
  address   = {Freiburg},
  issn      = {0172-0392},
  pages     = {Artikel HI 1380074},
  year      = {2012},
  language  = {de}
}
@article{KobusBitzUdenetal.2012,
  author    = {Kobus, Thiele and Bitz, Andreas and Uden, Mark J. van and Lagemaat, Miram W. and Rothgang, Eva and Orzada, Stephan and Heerschap, Arend and Scheenen, Tom W. J.},
  title     = {In vivo 31P MR spectroscopic imaging of the human prostate at 7 T: safety and feasibility},
  series = {Magnetic Resonance in Medicine},
  volume    = {68},
  journal   = {Magnetic Resonance in Medicine},
  number    = {6},
  publisher = {Wiley-Liss},
  address   = {New York},
  issn      = {1522-2594},
  doi       = {10.1002/mrm.24175},
  pages     = {1683 -- 1695},
  year      = {2012},
  abstract  = {31P MR spectroscopic imaging of the human prostate provides information about phosphorylated metabolites that could be used for prostate cancer characterization. The sensitivity of a magnetic field strength of 7 T might enable 3D 31P MR spectroscopic imaging with relevant spatial resolution in a clinically acceptable measurement time. To this end, a 31P endorectal coil was developed and combined with an eight-channel 1H body-array coil to relate metabolic information to anatomical location. An extensive safety validation was performed to evaluate the specific absorption rate, the radiofrequency field distribution, and the temperature distribution of both coils. This validation consisted of detailed Finite Integration Technique simulations, confirmed by MR thermometry and Burn:x-wiley:07403194:media:MRM24175:tex2gif-stack-1 measurements in a phantom and in vivo temperature measurements. The safety studies demonstrated that the presence of the 31P endorectal coil had no influence on the specific absorption rate levels and temperature distribution of the external eight-channel 1H array coil. To stay within a 10 g averaged local specific absorption rate of 10 W/kg, a maximum time-averaged input power of 33 W for the 1H array coil was allowed. For transmitting with the 31P endorectal coil, our safety limit of less than 1°C temperature increase in vivo during a 15-min MR spectroscopic imaging experiment was reached at a time-averaged input power of 1.9 W. With this power setting, a second in vivo measurement was performed on a healthy volunteer. Using adiabatic excitation, 3D 31P MR spectroscopic imaging produced spectra from the entire prostate in 18 min with a spatial resolution of 4 cm3. The spectral resolution enabled the separate detection of phosphocholine, phosphoethanolamine, inorganic phosphate, and other metabolites that could play an important role in the characterization of prostate cancer.},
  language  = {en}
}
@phdthesis{Kotliar2012,
  author    = {Kotliar, Konstantin},
  title     = {Pathophysiologische Beurteilung und h{\"a}modynamische Analyse von mikrostrukturellen Ver{\"a}nderungen des retinalen Gef{\"a}ßl{\"a}ngsschnittsprofils},
  pages     = {328 S.},
  year      = {2012},
  language  = {ru}
}
@article{KotliarLanzlHanssenetal.2012,
  author    = {Kotliar, Konstantin and Lanzl, Ines M. and Hanssen, Henner and Eberhardt, Karla and Vilser, Walthard and Halle, Martin and Heemann, Uwe and Schmidt-Trucks{\"a}ss, Arno and Baumann, Marcus},
  title     = {Does increased blood pressure rather than aging influence retinal pulse wave velocity?},
  series = {Investigative Ophthalmology \& Visual Science, IOVS},
  volume    = {53},
  journal   = {Investigative Ophthalmology \& Visual Science, IOVS},
  number    = {4},
  publisher = {ARVO},
  address   = {Rockville, Md.},
  issn      = {0146-0404},
  doi       = {10.1167/iovs.11-8815},
  pages     = {2119 -- 2126},
  year      = {2012},
  abstract  = {Purpose: It was demonstrated previously that retinal pulse wave velocity (rPWV) as a measure of retinal arterial stiffness is increased in aged anamnestically healthy volunteers compared with young healthy subjects. Using novel methodology of rPWV assessment this finding was confirmed and investigated whether it might relate to the increased blood pressure usually accompanying the aging process, rather than to the aging itself. Methods: A total of 12 young 25.5-year-old (24.0-28.8) [median(1st quartile-3rd quartile)] and 12 senior 68.5-year-old (63.8-71.8) anamnestically healthy volunteers; and 12 senior 63.0-year-old (60.8-65.0) validated healthy volunteers and 12 young 33.0-year-old (29.5-35.0) hypertensive patients were examined. Time-dependent alterations of vessel diameter were assessed by the Dynamic Vessel Analyzer in a retinal artery of each subject. The data were filtered and processed using mathematical signal analysis and rPWVs were calculated. Results: rPWV amounted to 1200 (990-1470) RU (relative units)/s in the hypertensive group and to 1040 (700-2230) RU/s in anamnestically healthy seniors. These differed significantly from rPWVs in young healthy group (410 [280-500] RU/s) and in validated healthy seniors (400 [320-510] RU/s). rPWV associated with age and mean arterial pressure (MAP) in the pooled cohort excluded validated healthy seniors. In a regression model these associations remain when alternately adjusted for MAP and age. When including validated healthy seniors in the pooled cohort only association with MAP remains. Conclusions: Both aging (with not excluded cardiovascular risk factors) and mild hypertension are associated with elevated rPWV. rPWV increases to a similar extent both in young mildly hypertensive subjects and in aged anamnestically healthy persons. Healthy aging is not associated with increased rPWV.},
  language  = {en}
}
@article{KrollLudwigs2012,
  author    = {Kroll-Ludwigs, Kathrin},
  title     = {Ein optionales Vertragsrecht f{\"u}r Europa: Motor oder Hemmnis f{\"u}r den Binnenmarkt?},
  series = {GPR : Zeitschrift f{\"u}r Gemeinschaftsprivatrecht},
  volume    = {9},
  journal   = {GPR : Zeitschrift f{\"u}r Gemeinschaftsprivatrecht},
  number    = {4},
  publisher = {Verlag Dr. Otto Schmidt},
  address   = {K{\"o}ln},
  issn      = {2193-9519},
  doi       = {10.1515/gpr.2012.9.4.181},
  pages     = {181 -- 188},
  year      = {2012},
  language  = {de}
}
@incollection{KuhlmannButenwegMeskourisetal.2012,
  author    = {Kuhlmann, Wolfram and Butenweg, Christoph and Meskouris, Konstantin and Kempen, Thomas},
  title     = {Simulation des Tragverhaltens des Aachener Doms im Erdbebenfall},
  series = {Die karolingische Pfalzkapelle in Aachen : Material, Bautechnik, Restaurierung. (Arbeitshefte der rheinischen Denkmalpflege ; 78)},
  booktitle = {Die karolingische Pfalzkapelle in Aachen : Material, Bautechnik, Restaurierung. (Arbeitshefte der rheinischen Denkmalpflege ; 78)},
  publisher = {Wernersche Verlags-Gesellschaft},
  address   = {Worms},
  isbn      = {978-3-88462-325-1},
  pages     = {237 -- 248},
  year      = {2012},
  language  = {de}
}
@inproceedings{KuhnhenneDoeringPyschnyetal.2012,
  author    = {Kuhnhenne, Markus and D{\"o}ring, Bernd and Pyschny, Dominik and Feldmann, Markus},
  title     = {Energy efficient sandwich construction},
  series = {Proceedings of the VI International Congress on Architectural Envelopes : 20.6. - 22.6.2012, San Sebastian, Spain},
  booktitle = {Proceedings of the VI International Congress on Architectural Envelopes : 20.6. - 22.6.2012, San Sebastian, Spain},
  publisher = {ICAE},
  organization    = {International Congress on Architectural Envelopes <6, 2012, San Sebastian>},
  pages     = {277 -- 285},
  year      = {2012},
  language  = {en}
}
@phdthesis{KurulganDemirci2012,
  author    = {Kurulgan Demirci, Eylem},
  title     = {The effect of rhAPC on contractile tension : an in-vitro sepsis model of cardiomyocytes and endothelial cells},
  year      = {2012},
  language  = {en}
}
@article{KurulganDemirciDemirciLinderetal.2012,
  author    = {Kurulgan Demirci, Eylem and Demirci, Taylan and Linder, Peter and Trzewik, J{\"u}rgen and Gierkowski, Jessica Ricarda and Gossmann, Matthias and Kayser, Peter and Porst, Dariusz and Digel, Ilya and Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l},
  title     = {rhAPC reduces the endothelial cell permeability via a decrease of contractile tensions induced by endothelial cells},
  series = {Journal of Bioscience and Bioengineering},
  volume    = {113},
  journal   = {Journal of Bioscience and Bioengineering},
  number    = {2},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1347-4421},
  doi       = {10.1016/j.jbiosc.2012.03.019},
  pages     = {212 -- 219},
  year      = {2012},
  abstract  = {All cells generate contractile tension. This strain is crucial for mechanically controlling the cell shape, function and survival. In this study, the CellDrum technology quantifying cell's (the cellular) mechanical tension on a pico-scale was used to investigate the effect of lipopolysaccharide (LPS) on human aortic endothelial cell (HAoEC) tension. The LPS effect during gram-negative sepsis on endothelial cells is cell contraction causing endothelium permeability increase. The aim was to finding out whether recombinant activated protein C (rhAPC) would reverse the endothelial cell response in an in-vitro sepsis model. In this study, the established in-vitro sepsis model was confirmed by interleukin 6 (IL-6) levels at the proteomic and genomic levels by ELISA, real time-PCR and reactive oxygen species (ROS) activation by florescence staining. The thrombin cellular contraction effect on endothelial cells was used as a positive control when the CellDrum technology was applied. Additionally, the Ras homolog gene family, member A (RhoA) mRNA expression level was checked by real time-PCR to support contractile tension results. According to contractile tension results, the mechanical predominance of actin stress fibers was a reason of the increased endothelial contractile tension leading to enhanced endothelium contractility and thus permeability enhancement. The originality of this data supports firstly the basic measurement principles of the CellDrum technology and secondly that rhAPC has a beneficial effect on sepsis influenced cellular tension. The technology presented here is promising for future high-throughput cellular tension analysis that will help identify pathological contractile tension responses of cells and prove further cell in-vitro models.},
  language  = {en}
}
@incollection{Kurz2012,
  author    = {Kurz, Melanie},
  title     = {Prizing \& Pricing : Design zwischen Rang und Regal},
  series = {Vielen Dank f{\"u}r Ihren Einkauf : Konsumkultur aus Sicht von Design, Kunst und Medien},
  booktitle = {Vielen Dank f{\"u}r Ihren Einkauf : Konsumkultur aus Sicht von Design, Kunst und Medien},
  publisher = {Transcript Verlag},
  address   = {Bielefeld},
  isbn      = {978-3-8376-2170-9},
  doi       = {10.1515/transcript.9783839421703.26},
  pages     = {26 -- 39},
  year      = {2012},
  language  = {de}
}
@inproceedings{KoetterDeckerDetzleretal.2012,
  author    = {K{\"o}tter, Jens and Decker, Stefan and Detzler, Raphael and Sch{\"a}fer, Jochen and Schmitz, Mark and Herrmann, Ulf},
  title     = {Cost Reduction of Solar Fields with HelioTrough Collector},
  publisher = {FLAGSOL},
  address   = {K{\"o}ln},
  pages     = {9 S. : Ill., graph. Darst.},
  year      = {2012},
  language  = {en}
}
@incollection{Laack2012,
  author    = {Laack, Walter van},
  title     = {Elektro- und Ultraschalltherapie},
  series = {Leitfaden Naturheilverfahren : f{\"u}r die {\"a}rztliche Praxis},
  booktitle = {Leitfaden Naturheilverfahren : f{\"u}r die {\"a}rztliche Praxis},
  editor    = {Beer, Andr{\´e}-Michael and Adler, Martin},
  publisher = {Elsevier},
  address   = {Amsterdam},
  isbn      = {978-3-437-56103-0},
  doi       = {10.1016/B978-3-437-56103-0.10013-5},
  pages     = {285 -- 299},
  year      = {2012},
  language  = {de}
}
@book{Laack2012,
  author    = {Laack, Walter van},
  title     = {Schnittstelle Tod: Warum auf ein Danach vertrauen?},
  publisher = {Books on Demand},
  address   = {Norderstedt},
  isbn      = {978-3-936624-14-4},
  pages     = {120 S. : Ill.,graph. Darst.},
  year      = {2012},
  language  = {de}
}
@article{LaumannMainz2012,
  author    = {Laumann, J{\"o}rg and Mainz, Stefan},
  title     = {Direkte Ermittlung der erforderlichen Einspanntiefe von I‑f{\"o}rmigen Stahlquerschnitten in Betonkonstruktionen},
  volume    = {81},
  number    = {11},
  publisher = {Wiley},
  address   = {Weinheim},
  issn      = {1437-1049},
  doi       = {10.1002/stab.201201620},
  pages     = {850 -- 860},
  year      = {2012},
  abstract  = {F{\"u}r die Ermittlung der erforderlichen Einspanntiefe von eingespannten Stahlquerschnitten in Betonkonstruktionen existieren verschiedene Bemessungsmodelle. Diese basieren vorwiegend auf Grundlage nationaler Normen wie z. B. DIN 18800 [1] und DIN 1045 [2], die durch die europ{\"a}ische Normung ersetzt wurden. Aus diesem Grund wird in diesem Aufsatz ein Berechnungsmodell f{\"u}r die erforderliche Einspanntiefe von eingespannten Stahlquerschnitten in Betonkonstruktionen auf Grundlage des Eurocodes vorgestellt. Das Grundger{\"u}st f{\"u}r dieses Berechnungsmodell bildet das Verfahren nach Kindmann und Laumann, welches in [3] behandelt wurde. Gleichzeitig werden neue Formeln zur direkten Ermittlung der Mindesteinspanntiefe vorgestellt. Behandelt werden gewalzte I-Profile f{\"u}r einachsige Biegung um die starke Achse (y-y) mit Drucknormalkraft.},
  language  = {de}
}
@article{LeidingerNoistenWollert2012,
  author    = {Leidinger, Rafael and Noisten, Thomas and Wollert, J{\"o}rg},
  title     = {Realtime automation networks in moVing industrial environments},
  series = {Journal of systemics, cybernetics and informatics},
  volume    = {Vol. 10},
  journal   = {Journal of systemics, cybernetics and informatics},
  number    = {Iss. 2},
  publisher = {IIIC},
  address   = {Orlando},
  issn      = {1690-4532},
  pages     = {52 -- 56},
  year      = {2012},
  abstract  = {The radio-based wireless data communication has made the realization of new technical solutions possible in many fields of the automation technology (AT). For about ten years, a constant disproportionate growth of wireless technologies can be observed in the automation technology. However, it shows that especially for the AT, conventional technologies of office automation are unsuitable and/or not manageable. The employment of mobile services in the industrial automation technology has the potential of significant cost and time savings. This leads to an increased productivity in various fields of the AT, for example in the factory and process automation or in production logistics. In this paper technologies and solutions for an automation-suited supply of mobile wireless services will be introduced under the criteria of real time suitability, IT-security and service orientation. Emphasis will be put on the investigation and development of wireless convergence layers for different radio technologies, on the central provision of support services for an easy-to-use, central, backup enabled management of combined wired / wireless networks and on the study on integrability in a Profinet real-time Ethernet network.},
  language  = {en}
}
@article{LempiaeinenCouttetBolognanietal.2012,
  author    = {Lempi{\"a}inen, Harri and Couttet, Philippe and Bolognani, Federico and M{\"u}ller, Arne and Dubost, Val{\´e}rie and Luisier, Rapha{\"e}lle and Rio-Espinola, Alberto del and Vitry, Veronique and Unterberger, Elif B. and Thomson, John P. and Treindl, Fridolin and Metzger, Ute and Wrzodek, Clemens and Hahne, Florian and Zollinger, Tulipan and Brasa, Sarah and Kalteis, Magdalena and Marcellin, Magali and Giudicelli, Fanny and Braeuning, Albert and Morawiec, Laurent and Zamurovic, Natasa and L{\"a}ngle, Ulrich and Scheer, Nico and Sch{\"u}beler, Dirk and Goodman, Jay and Chibout, Salah-Dine and Marlowe, Jennifer and Theil, Dietlinde and Heard, David J. and Grenet, Olivier and Zell, Andreas and Templin, Markus F. and Meehan, Richard R. and Wolf, Roland C. and Elcombe, Clifford R. and Schwarz, Michael and Moulin, Pierre and Terranova, R{\´e}mi and Moggs, Jonathan G.},
  title     = {Identification of Dlk1-Dio3 imprinted gene cluster non-coding RNAs as novel candidate biomarkers for liver tumor promotion},
  series = {Toxicological Sciences},
  volume    = {131},
  journal   = {Toxicological Sciences},
  number    = {2},
  publisher = {Oxford University Press},
  address   = {Oxford},
  issn      = {1094-2025},
  doi       = {10.1093/toxsci/kfs303},
  pages     = {375 -- 386},
  year      = {2012},
  abstract  = {The molecular events during nongenotoxic carcinogenesis and their temporal order are poorly understood but thought to include long-lasting perturbations of gene expression. Here, we have investigated the temporal sequence of molecular and pathological perturbations at early stages of phenobarbital (PB) mediated liver tumor promotion in vivo. Molecular profiling (mRNA, microRNA [miRNA], DNA methylation, and proteins) of mouse liver during 13 weeks of PB treatment revealed progressive increases in hepatic expression of long noncoding RNAs and miRNAs originating from the Dlk1-Dio3 imprinted gene cluster, a locus that has recently been associated with stem cell pluripotency in mice and various neoplasms in humans. PB induction of the Dlk1-Dio3 cluster noncoding RNA (ncRNA) Meg3 was localized to glutamine synthetase-positive hypertrophic perivenous hepatocytes, sug- gesting a role for β-catenin signaling in the dysregulation of Dlk1-Dio3 ncRNAs. The carcinogenic relevance of Dlk1-Dio3 locus ncRNA induction was further supported by in vivo genetic dependence on constitutive androstane receptor and β-catenin pathways. Our data identify Dlk1-Dio3 ncRNAs as novel candidate early biomarkers for mouse liver tumor promotion and provide new opportunities for assessing the carcinogenic potential of novel compounds.},
  language  = {en}
}
@article{LeursMezoOehlschlaegeretal.2012,
  author    = {Leurs, Ulrike and Mezo, Gabor and {\"O}hlschl{\"a}ger, Peter and Orban, Erika and Marquard, Andrea and Manea, Marilena},
  title     = {Design, synthesis, in vitro stability and cytostatic effect of multifunctional anticancer drug-bioconjugates containing GnRH-III as a targeting moiety},
  series = {Peptide Science},
  volume    = {98},
  journal   = {Peptide Science},
  number    = {1},
  publisher = {Wiley},
  address   = {New York, NY},
  issn      = {1097-0282},
  doi       = {10.1002/bip.21640},
  pages     = {1 -- 10},
  year      = {2012},
  abstract  = {Bioconjugates containing the GnRH-III hormone decapeptide as a targeting moiety are able to deliver chemotherapeutic agents specifically to cancer cells expressing GnRH receptors, thereby increasing their local efficacy while limiting the peripheral toxicity. However, the number of GnRH receptors on cancer cells is limited and they desensitize under continuous hormone treatment. A possible approach to increase the receptor mediated tumor targeting and consequently the cytostatic effect of the bioconjugates would be the attachment of more than one chemotherapeutic agent to one GnRH-III molecule. Here we report on the design, synthesis and biochemical characterization of multifunctional bioconjugates containing GnRH-III as a targeting moiety and daunorubicin as a chemotherapeutic agent. Two different drug design approaches were pursued. The first one was based on the bifunctional [4Lys]-GnRH-III (Glp-His-Trp-Lys-His-Asp-Trp-Lys-Pro-Gly-NH2) containing two lysine residues in positions 4 and 8, whose ϵ-amino groups were used for the coupling of daunorubicin. In the second drug design, the native GnRH-III (Glp-His-Trp-Ser-His-Asp-Trp-Lys-Pro-Gly-NH2) was used as a scaffold; an additional lysine residue was coupled to the ϵ-amino group of 8Lys in order to generate two free amino groups available for conjugation of daunorubicin. The in vitro stability/degradation of all synthesized compounds was investigated in human serum, as well as in the presence of rat liver lysosomal homogenate. Their cellular uptake was determined on human breast cancer cells and the cytostatic effect was evaluated on human breast, colon and prostate cancer cell lines. Compared with a monofunctional compound, both drug design approaches resulted in multifunctional bioconjugates with increased cytostatic effect.},
  language  = {en}
}
@article{Lind2012,
  author    = {Lind, Thorsten Patric},
  title     = {Zur Rechtsscheinhaftung bei Handeln einer Unternehmergesellschaft unter dem Rechtsformzusatz „GmbH" : Urteil vom 12.06.2012 - II ZR 256/11 : Anmerkung},
  series = {Fachdienst Zivilrecht - LMK - Kommentierte BGH-Rechtsprechung, Lindenmaier-M{\"o}hring},
  journal   = {Fachdienst Zivilrecht - LMK - Kommentierte BGH-Rechtsprechung, Lindenmaier-M{\"o}hring},
  number    = {Ausg. 11},
  publisher = {Beck},
  address   = {M{\"u}nchen},
  issn      = {1611-1095},
  pages     = {339268},
  year      = {2012},
  language  = {de}
}