@inproceedings{OberlaenderKirchnerKeusgenetal.2014, author = {Oberl{\"a}nder, Jan and Kirchner, Patrick and Keusgen, M. and Sch{\"o}ning, Michael Josef}, title = {Flexible polyimide-based calorimetric gas sensors for monitoring hy-drogen peroxide in sterilisation processes of aseptic filling machines}, series = {Sensoren und Messsysteme 2014 ; Beitr{\"a}ge der 17. GMA/ITG-Fachtagung vom 3. bis 4. Juni 2014 in N{\"u}rnberg. (ITG-Fachbericht ; 250)}, booktitle = {Sensoren und Messsysteme 2014 ; Beitr{\"a}ge der 17. GMA/ITG-Fachtagung vom 3. bis 4. Juni 2014 in N{\"u}rnberg. (ITG-Fachbericht ; 250)}, publisher = {VDE-Verl.}, address = {D{\"u}sseldorf}, organization = {VDI/VDE-Gesellschaft Mess- und Automatisierungstechnik}, isbn = {978-3-8007-3622-5}, pages = {1 -- 4}, year = {2014}, language = {en} } @article{PasteurTippkoetterKampeisetal.2014, author = {Pasteur, Aline and Tippk{\"o}tter, Nils and Kampeis, Percy and Ulber, Roland}, title = {Optimization of high gradient magnetic separation filter units for the purification of fermentation products}, series = {IEEE TRANSACTIONS ON MAGNETICS}, volume = {50}, journal = {IEEE TRANSACTIONS ON MAGNETICS}, number = {10}, publisher = {IEEE}, address = {New York, NY}, issn = {0018-9464}, doi = {10.1109/TMAG.2014.2325535}, pages = {Artikel 5000607}, year = {2014}, abstract = {High gradient magnetic separation (HGMS) has been established since the early 1970s. A more recent application of these systems is the use in bioprocesses. To integrate the HGMS in a fermentation process, it is necessary to optimize the separation matrix with regard to the magnetic separation characteristics and permeability of the non-magnetizable components of the fermentation broth. As part of the work presented here, a combined fluidic and magnetic force finite element model simulation was created using the software COMSOL Multiphysics and compared with separation experiments. Finally, as optimal lattice orientation of the separation matrix, a transversal rhombohedral arrangement was defined. The high suitability of the new filter matrix has been verified by separation experiments.}, language = {en} } @article{PhamStaat2014, author = {Pham, Phu Tinh and Staat, Manfred}, title = {FEM-based shakedown analysis of hardening structures}, series = {Asia Pacific journal on computational engineering}, journal = {Asia Pacific journal on computational engineering}, number = {1}, publisher = {SpringerOpen}, address = {Berlin}, issn = {2196-1166 (E-Journal)}, doi = {10.1186/2196-1166-1-4}, pages = {Article No. 4}, year = {2014}, abstract = {This paper develops a new finite element method (FEM)-based upper bound algorithm for limit and shakedown analysis of hardening structures by a direct plasticity method. The hardening model is a simple two-surface model of plasticity with a fixed bounding surface. The initial yield surface can translate inside the bounding surface, and it is bounded by one of the two equivalent conditions: (1) it always stays inside the bounding surface or (2) its centre cannot move outside the back-stress surface. The algorithm gives an effective tool to analyze the problems with a very high number of degree of freedom. Our numerical results are very close to the analytical solutions and numerical solutions in literature.}, language = {en} } @inproceedings{PieperSchulz2014, author = {Pieper, Martin and Schulz, Silvia}, title = {Teaching Simulation Methods with COMSOL Multiphysics}, organization = {COMSOL Conference <2014, Cambridge>}, pages = {7}, year = {2014}, abstract = {This paper describes two courses on simulation methods for graduate students: "Simulation Methods" and "Simulation and Optimization in Virtual Engineering" The courses were planned to teach young engineers how to work with simulation software as well as to understand the necessary mathematical background. As simulation software COMSOL is used. The main philosophy was to combine theory and praxis in a way that motivates the students. In addition "soft skills" should be improved. This was achieved by project work as final examination. As underlying didactical principle the ideas of Bloom's revised taxonomy were followed. The paper basically focusses on educational aspects, e.g. how to structure the course, plan the exercises, organize the project work and include practical COMSOL examples.}, language = {en} } @article{PoghossianSchoening2014, author = {Poghossian, Arshak and Sch{\"o}ning, Michael Josef}, title = {Label-free sensing of biomolecules with field-effect devices for clinical applications}, series = {Electroanalysis}, volume = {26}, journal = {Electroanalysis}, number = {6}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1521-4109 (E-Journal); 1040-0397 (Print)}, doi = {10.1002/elan.201400073}, pages = {1197 -- 1213}, year = {2014}, abstract = {Among the variety of transducer concepts proposed for label-free detection of biomolecules, the semiconductor field-effect device (FED) is one of the most attractive platforms. As medical techniques continue to progress towards diagnostic and therapies based on biomarkers, the ability of FEDs for a label-free, fast and real-time detection of multiple pathogenic and physiologically relevant molecules with high specificity and sensitivity offers very promising prospects for their application in point-of-care and personalized medicine for an early diagnosis and treatment of diseases. The presented paper reviews recent advances and current trends in research and development of different FEDs for label-free, direct electrical detection of charged biomolecules by their intrinsic molecular charge. The authors are mainly focusing on the detection of the DNA hybridization event, antibody-antigen affinity reaction as well as clinically relevant biomolecules such as cardiac and cancer biomarkers.}, language = {en} } @incollection{PoghossianWeilandSchoening2014, author = {Poghossian, Arshak and Weiland, Maryam and Sch{\"o}ning, Michael Josef}, title = {Nanoplate field-effect capacitors: a new transducer structure for multiparameter (bio-)chemical sensing}, series = {Multisensor system for chemical analysis : materials and sensors}, booktitle = {Multisensor system for chemical analysis : materials and sensors}, editor = {Lvova, Larisa and Kirsanov, Dmitry and di Natale, Corrado and Legin, Audrey}, edition = {1}, publisher = {Jenny Stanford Publishing}, address = {Singapore}, isbn = {978-981-4411-15-8 ; 978-981-4411-16-5}, doi = {10.1201/b15491-11}, pages = {333 -- 373}, year = {2014}, abstract = {An array of electrically isolated nanoplate field-effect silicon-on-insulator (SOI) capacitors as a new transducer structure for multiparameter (bio-)chemical sensing is presented. The proposed approach allows addressable biasing and electrical readout of multiple nanoplate field-effect capacitive (bio-)chemical sensors on the same SOI chip, as well as differential-mode measurements. The realized sensor chip has been applied for pH and penicillin concentration measurements, electrical monitoring of polyelectrolyte multilayer formation, and the label-free electrical detection of consecutive deoxyribonucleic acid (DNA) hybridization and denaturation events.}, language = {en} } @article{RatkeMilowLisinskietal.2014, author = {Ratke, Lorenz and Milow, Barbara and Lisinski, Susanne and Hoepfner, Sandra}, title = {On an effect of fine ceramic particles on the structure of aerogels}, series = {Microgravity science and technology}, volume = {26}, journal = {Microgravity science and technology}, publisher = {Springer Nature}, address = {Heidelberg}, issn = {0938-0108 ; 1875-0494}, doi = {10.1007/s12217-014-9380-2}, pages = {103 -- 110}, year = {2014}, language = {en} } @article{RauAlexopoulosBreitbachetal.2014, author = {Rau, Christoph and Alexopoulos, Spiros and Breitbach, Gerd and Hoffschmidt, Bernhard and Latzke, Markus and Sattler, Johannes, Christoph}, title = {Transient simulation of a solar-hybrid tower power plant with open volumetric receiver at the location Barstow}, series = {Energy procedia : proceedings of the SolarPACES 2013 International Conference}, volume = {49}, journal = {Energy procedia : proceedings of the SolarPACES 2013 International Conference}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1876-6102}, doi = {10.1016/j.egypro.2014.03.157}, pages = {1481 -- 1490}, year = {2014}, abstract = {In this work the transient simulations of four hybrid solar tower power plant concepts with open-volumetric receiver technology for a location in Barstow-Daggett, USA, are presented. The open-volumetric receiver uses ambient air as heat transfer fluid and the hybridization is realized with a gas turbine. The Rankine cycle is heated by solar-heated air and/or by the gas turbine's flue gases. The plant can be operated in solar-only, hybrid parallel or combined cycle-only mode as well as in any intermediate load levels where the solar portion can vary between 0 to 100\%. The simulated plant is based on the configuration of a solar-hybrid power tower project, which is in planning for a site in Northern Algeria. The meteorological data for Barstow-Daggett was taken from the software meteonorm. The solar power tower simulation tool has been developed in the simulation environment MATLAB/Simulink and is validated.}, language = {en} } @article{RaueWambachGloeggleretal.2014, author = {Raue, Markus and Wambach, M. and Gl{\"o}ggler, S. and Grefen, Dana and Kaufmann, R. and Abetz, C. and Georgopanos, P. and Handge, U. A. and Mang, Thomas and Bl{\"u}mich, B. and Abetz, V.}, title = {Investigation of historical hard rubber ornaments of Charles Goodyear}, series = {Macromolecular chemistry and physics}, volume = {Vol. 215}, journal = {Macromolecular chemistry and physics}, number = {No. 3}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1022-1352}, pages = {245 -- 254}, year = {2014}, language = {en} } @misc{ReyesOchoa2014, type = {Master Thesis}, author = {Reyes Ochoa, Leonel}, title = {Engineering aspects of a parabolic trough collector field with direct steam generation and an organic rankine cycle}, publisher = {Fachhochschule Aachen}, address = {Aachen}, pages = {X, 72 S.}, year = {2014}, language = {en} } @article{RiedelKartchemnikSchoeningetal.2014, author = {Riedel, Marc and Kartchemnik, Julia and Sch{\"o}ning, Michael Josef and Lisdat, Fred}, title = {Impedimetric DNA detection - steps forward to sensorial application}, series = {Analytical chemistry}, volume = {86 (2014)}, journal = {Analytical chemistry}, number = {15}, publisher = {ACS Publications}, address = {Columbus}, issn = {1520-6882 (E-Journal); 0003-2700 (Print); 0096-4484 (Print)}, doi = {10.1021/ac501800q}, pages = {7867 -- 7874}, year = {2014}, abstract = {This study describes a label-free impedimetric sensor based on short ssDNA recognition elements for the detection of hybridization events. We concentrate on the elucidation of the influence of target length and recognition sequence position on the sensorial performance. The impedimetric measurements are performed in the presence of the redox system ferri-/ferrocyanide and show an increase in charge transfer resistance upon hybridization of ssDNA to the sensor surface. Investigations on the impedimetric signal stability demonstrate a clear influence of the buffers used during the sensor preparation and the choice of the passivating mercaptoalcanol compound. A stable sensor system has been developed, enabling a reproducible detection of 25mer target DNA in the low nanomolar range. After hybridization, a sensor regeneration can be reached with deionized water by adjustment of effective convection conditions, ensuring a sensor reusability. By investigations of longer targets with overhangs exposed to the solution, we can demonstrate applicability of the impedimetric detection for longer ssDNA. However, a decreasing charge transfer resistance change (ΔRct) is found by extending the overhang. As a strategy to increase the impedance change for longer target strands, the position of the recognition sequence can be designed in a way that a small overhang is exposed to the electrode surface. This is found to result in an increase in the relative Rct change. These results suggest that DNA and consequently negative charge near the electrode possess a larger impact on the impedimetric signal than DNA further away.}, language = {en} } @inproceedings{RitzIzquierdoTelloDamm2014, author = {Ritz, Thomas and Izquierdo Tello, C{\´e}sar and Damm, Sebastian}, title = {Connecting a pedelec to the cloud as basis for gamification in multi modal mobility planning}, series = {MobileCloud 2014 : 2nd IEEE International Conference on Mobile Cloud Computing, Services, and Engineering Oxford, United Kingdom 7-10 April 2014}, booktitle = {MobileCloud 2014 : 2nd IEEE International Conference on Mobile Cloud Computing, Services, and Engineering Oxford, United Kingdom 7-10 April 2014}, publisher = {IEEE Service Center}, address = {Piscataway, NJ}, isbn = {978-1-4799-2504-9}, doi = {10.1109/MobileCloud.2014.25}, pages = {101 -- 108}, year = {2014}, language = {en} } @inproceedings{RosinButenweg2014, author = {Rosin, Julia and Butenweg, Christoph}, title = {Seismic isolation of cylindrical liquid storage tanks}, series = {Proceedings of the 9th European Conference on Structural Dynamics, EURODYN 2014 Porto, Portugal, 30 June - 2 July 2014 / A. Cunha, E. Caetano, .... (eds.)}, booktitle = {Proceedings of the 9th European Conference on Structural Dynamics, EURODYN 2014 Porto, Portugal, 30 June - 2 July 2014 / A. Cunha, E. Caetano, .... (eds.)}, address = {Porto}, organization = {European Conference on Structural Dynamics, EURODYN <9, 2014, Porto>}, isbn = {978-972-752-165-4}, pages = {3145 -- 3152}, year = {2014}, language = {en} } @inproceedings{RosinHenneboehlButenweg2014, author = {Rosin, Julia and Henneb{\"o}hl, Benedickt and Butenweg, Christoph}, title = {Global buckling analysis of cylindrical liquid storage tanks under earthquake loading}, series = {2nd European Conference on Earthquake Engineering and Seismology 2014 (2nd ECEES) : joint event of the 15th European Conference on Earthquake Engineering and the 34th General Assembly of the European Seismological Commission : Istanbul, Turkey, 25-29 August 2014 / European Association for Earthquake Engineering (EAEE) ; Vol. 6}, booktitle = {2nd European Conference on Earthquake Engineering and Seismology 2014 (2nd ECEES) : joint event of the 15th European Conference on Earthquake Engineering and the 34th General Assembly of the European Seismological Commission : Istanbul, Turkey, 25-29 August 2014 / European Association for Earthquake Engineering (EAEE) ; Vol. 6}, publisher = {Curran Associates, Inc.}, address = {Red Hook, NY}, organization = {European Conference on Earthquake Engineering and Seismology <2, 2014, Istanbul>}, isbn = {978-1-5108-1021-1}, pages = {5270 -- 5281}, year = {2014}, language = {en} } @inproceedings{RosinKubalskiButenweg2014, author = {Rosin, Julia and Kubalski, Thomas and Butenweg, Christoph}, title = {Seismic Design of cylindrical liquid storage tanks}, series = {Seismic design of industrial facilities : proceedings of the International Conference on Seismic Design of Industrial Facilities (SeDIF-Conference) ; [Aachen, 26. - 27. September 2013] / Chair of Structural Statics and Dynamics, RWTH Aachen. Sven Klinkel ..., ed.}, booktitle = {Seismic design of industrial facilities : proceedings of the International Conference on Seismic Design of Industrial Facilities (SeDIF-Conference) ; [Aachen, 26. - 27. September 2013] / Chair of Structural Statics and Dynamics, RWTH Aachen. Sven Klinkel ..., ed.}, publisher = {Springer Vieweg}, address = {Wiesbaden}, organization = {International Conference on Seismic Design of Industrial Facilities <2013, Aachen>}, isbn = {978-3-658-02810-7 (E-Book) ; 978-3-658-02809-1 (Print)}, doi = {10.1007/978-3-658-02810-7_36}, pages = {429 -- 440}, year = {2014}, language = {en} } @inproceedings{RousseauKern2014, author = {Rousseau, Alain and Kern, Alexander}, title = {How to deal with environmental risk in IEC 62305-2}, series = {2014 International Conference on Lightning Protection (ICLP), Shanghai, China}, booktitle = {2014 International Conference on Lightning Protection (ICLP), Shanghai, China}, organization = {International Conference on Lightning Protection <2014, Shanghai>}, pages = {521 -- 527}, year = {2014}, abstract = {The 2nd edition of the lightning risk management standard (IEC 62305-2) considers structures, which may endanger environment. In these cases, the loss is not limited to the structure itself, which is valid for usual structures. In the past (Edition 1) this danger was simply taken into account by a special hazard factor, multiplying the existing risk for the structure with a number. Now, in the edition 2, we add to the risk for the structure itself a "second risk" due to the losses outside the structure. The losses outside can be treated independently from what occurs inside. This is a major advantage to analyze the risk for sensitive structures, like chemical plants, nuclear plants, or structures containing explosives, etc. In this paper, the existing procedure given by the European version EN 62305-2 Ed.2 is further developed and applied to a few structures.}, language = {en} } @article{SalpatiChuChenetal.2014, author = {Salpati, Laurent and Chu, Xiaoyan and Chen, Liangfu and Prasad, Bhagwat and Dallas, Shannon and Evers, Raymond and Mamaril-Fishman, Donna and Geier, Ethan G. and Kehler, Jonathan and Kunta, Jeevan and Mezler, Mario and Laplanche, Loic and Pang, Jodie and Soars, Matthew G. and Unadkat, Jashvant D. and van Waterschoot, Robert A.B. and Yabut, Jocelyn and Schinkel, Alfred H. and Scheer, Nico and Rode, Anja}, title = {Evaluation of organic anion transporting polypeptide 1B1 and 1B3 humanized mice as a translational model to study the pharmacokinetics of statins}, series = {Drug Metabolism and Disposition}, volume = {42}, journal = {Drug Metabolism and Disposition}, number = {8}, publisher = {ASPET}, address = {Bethesda, Md.}, issn = {1521-009X}, doi = {10.1124/dmd.114.057976}, pages = {1301 -- 1313}, year = {2014}, abstract = {Organic anion transporting polypeptide (Oatp) 1a/1b knockout and OATP1B1 and -1B3 humanized mouse models are promising tools for studying the roles of these transporters in drug disposition. Detailed characterization of these models will help to better understand their utility for predicting clinical outcomes. To advance this approach, we carried out a comprehensive analysis of these mouse lines by evaluating the compensatory changes in mRNA expression, quantifying the amounts of OATP1B1 and -1B3 protein by liquid chromatography-tandem mass spectrometry, and studying the active uptake in isolated hepatocytes and the pharmacokinetics of some prototypical substrates including statins. Major outcomes from these studies were 1) mostly moderate compensatory changes in only a few genes involved in drug metabolism and disposition, 2) a robust hepatic expression of OATP1B1 and -1B3 proteins in the respective humanized mouse models, and 3) functional activities of the human transporters in hepatocytes isolated from the humanized models with several substrates tested in vitro and with pravastatin in vivo. However, the expression of OATP1B1 and -1B3 in the humanized models did not significantly alter liver or plasma concentrations of rosuvastatin and pitavastatin compared with Oatp1a/1b knockout controls under the conditions used in our studies. Hence, although the humanized OATP1B1 and -1B3 mice showed in vitro and/or in vivo functional activity with some statins, further characterization of these models is required to define their potential use and limitations in the prediction of drug disposition and drug-drug interactions in humans.}, language = {en} } @article{SawadaNakazawaTakenagaetal.2014, author = {Sawada, Kazuaki and Nakazawa, Hirokazu and Takenaga, Shoko and Hizawa, Takeshi and Futagawa, Masato and Dasai, Fumihiro and Sakurai, Takashi and Okumura, Koichi and Hattori, Toshiaki and Ishida, Makoto}, title = {Multimodal bioimage sensor}, series = {IEICE transactions on fundamentals of electronics, communidations and computer sciences}, volume = {E97-A (2014)}, journal = {IEICE transactions on fundamentals of electronics, communidations and computer sciences}, number = {3}, publisher = {IEICE}, address = {Tokyo}, issn = {0916-8508 (Print) ; 1745-1337 (Online)}, doi = {10.1587/transfun.E97.A.726}, pages = {726 -- 733}, year = {2014}, abstract = {To visualize the biochemical distribution two-dimensionally, we invented a solid-state-type ion image sensor that indicates the chemical activity of solutions and cells. The device, which consists of a CCD array covered with a functionalized membrane to detect charge accumulation, is highly sensitive to changes in the concentration and two-dimensional distribution of ions and biomaterials.}, language = {en} } @article{ScheerMclaughlinRodeetal.2014, author = {Scheer, Nico and Mclaughlin, Lesley A. and Rode, Anja and MacLeod, Alastair Kenneth and Henderson, Colin J. and Wolf, Roland C.}, title = {Deletion of thirty murine cytochrome P450 genes results in viable mice with compromised drug metabolism}, series = {Drug Metabolism and Disposition}, volume = {42}, journal = {Drug Metabolism and Disposition}, number = {6}, publisher = {ASPET}, address = {Bethesda, Md.}, issn = {1521-009X}, doi = {10.1124/dmd.114.057885}, pages = {1022 -- 1030}, year = {2014}, abstract = {In humans, 75\% of all drugs are metabolized by the cytochrome P450-dependent monooxygenase system. Enzymes encoded by the CYP2C, CYP2D, and CYP3A gene clusters account for ∼80\% of this activity. There are profound species differences in the multiplicity of cytochrome P450 enzymes, and the use of mouse models to predict pathways of drug metabolism is further complicated by overlapping substrate specificity between enzymes from different gene families. To establish the role of the hepatic and extrahepatic P450 system in drug and foreign chemical disposition, drug efficacy, and toxicity, we created a unique mouse model in which 30 cytochrome P450 genes from the Cyp2c, Cyp2d, and Cyp3a gene clusters have been deleted. Remarkably, despite a wide range of putative important endogenous functions, Cyp2c/2d/3a KO mice were viable and fertile, demonstrating that these genes have evolved primarily as detoxification enzymes. Although there was no overt phenotype, detailed examination showed Cyp2c/2d/3a KO mice had a smaller body size (15\%) and larger livers (20\%). Changes in hepatic morphology and a decreased blood glucose (30\%) were also noted. A five-drug cocktail of cytochrome P450 isozyme probe substrates were used to evaluate changes in drug pharmacokinetics; marked changes were observed in either the pharmacokinetics or metabolites formed from Cyp2c, Cyp2d, and Cyp3a substrates, whereas the metabolism of the Cyp1a substrate caffeine was unchanged. Thus, Cyp2c/2d/3a KO mice provide a powerful model to study the in vivo role of the P450 system in drug metabolism and efficacy, as well as in chemical toxicity.}, language = {en} } @article{ScheerWolf2014, author = {Scheer, Nico and Wolf, C. Roland}, title = {Genetically humanized mouse models of drug metabolizing enzymes and transporters and their applications}, series = {Xenobiotica}, volume = {44}, journal = {Xenobiotica}, number = {2}, publisher = {Taylor \& Francis}, address = {Abingdon}, issn = {1366-5928}, doi = {10.3109/00498254.2013.815831}, pages = {96 -- 108}, year = {2014}, abstract = {1. Drug metabolizing enzymes and transporters play important roles in the absorption, metabolism, tissue distribution and excretion of various compounds and their metabolites and thus can significantly affect their efficacy and safety. Furthermore, they can be involved in drug-drug interactions which can result in adverse responses, life-threatening toxicity or impaired efficacy. Significant species differences in the interaction of compounds with drug metabolizing enzymes and transporters have been described. 2. In order to overcome the limitation of animal models in accurately predicting human responses, a large variety of mouse models humanized for drug metabolizing enzymes and to a lesser extent drug transporters have been created. 3. This review summarizes the literature describing these mouse models and their key applications in studying the role of drug metabolizing enzymes and transporters in drug bioavailability, tissue distribution, clearance and drug-drug interactions as well as in human metabolite testing and risk assessment. 4. Though such humanized mouse models have certain limitations, there is great potential for their use in basic research and for testing and development of new medicines. These limitations and future potentials will be discussed.}, language = {en} }