@article{AlmajhdiSengerAmeretal.2014,
  author    = {Almajhdi, Fahad N. and Senger, Tilo and Amer, Haitham M. and Gissmann, Lutz and {\"O}hlschl{\"a}ger, Peter},
  title     = {Design of a highly effective therapeutic HPV16 E6/E7-specific DNA vaccine: optimization by different ways of sequence rearrangements (Shuffling)},
  series = {PLOS one},
  volume    = {11},
  journal   = {PLOS one},
  number    = {9},
  publisher = {PLOS},
  address   = {San Francisco},
  issn      = {1932-6203},
  doi       = {10.1371/journal.pone.0113461},
  pages     = {e113461},
  year      = {2014},
  abstract  = {Persistent infection with the high-risk Human Papillomavirus type 16 (HPV 16) is the causative event for the development of cervical cancer and other malignant tumors of the anogenital tract and of the head and neck. Despite many attempts to develop therapeutic vaccines no candidate has entered late clinical trials. An interesting approach is a DNA based vaccine encompassing the nucleotide sequence of the E6 and E7 viral oncoproteins. Because both proteins are consistently expressed in HPV infected cells they represent excellent targets for immune therapy. Here we report the development of 8 DNA vaccine candidates consisting of differently rearranged HPV-16 E6 and E7 sequences within one molecule providing all naturally occurring epitopes but supposedly lacking transforming activity. The HPV sequences were fused to the J-domain and the SV40 enhancer in order to increase immune responses. We demonstrate that one out of the 8 vaccine candidates induces very strong cellular E6- and E7- specific cellular immune responses in mice and, as shown in regression experiments, efficiently controls growth of HPV 16 positive syngeneic tumors. This data demonstrates the potential of this vaccine candidate to control persistent HPV 16 infection that may lead to malignant disease. It also suggests that different sequence rearrangements influence the immunogenecity by an as yet unknown mechanism.},
  language  = {en}
}
@article{AlnemerKotliarNeuhausetal.2023,
  author    = {Alnemer, Momin Sami Mohammad and Kotliar, Konstantin and Neuhaus, Valentin and Pape, Hans-Christoph and Ciritsis, Bernhard D.},
  title     = {Cost-effectiveness analysis of surgical proximal femur fracture prevention in elderly: a Markov cohort simulation model},
  series = {Cost Effectiveness and Resource Allocation},
  journal   = {Cost Effectiveness and Resource Allocation},
  number    = {21, Article number: 77},
  publisher = {Springer Nature},
  issn      = {1478-7547},
  doi       = {10.1186/s12962-023-00482-4},
  pages     = {12 Seiten},
  year      = {2023},
  abstract  = {Background Hip fractures are a common and costly health problem, resulting in significant morbidity and mortality, as well as high costs for healthcare systems, especially for the elderly. Implementing surgical preventive strategies has the potential to improve the quality of life and reduce the burden on healthcare resources, particularly in the long term. However, there are currently limited guidelines for standardizing hip fracture prophylaxis practices. Methods This study used a cost-effectiveness analysis with a finite-state Markov model and cohort simulation to evaluate the primary and secondary surgical prevention of hip fractures in the elderly. Patients aged 60 to 90 years were simulated in two different models (A and B) to assess prevention at different levels. Model A assumed prophylaxis was performed during the fracture operation on the contralateral side, while Model B included individuals with high fracture risk factors. Costs were obtained from the Centers for Medicare \& Medicaid Services, and transition probabilities and health state utilities were derived from available literature. The baseline assumption was a 10\% reduction in fracture risk after prophylaxis. A sensitivity analysis was also conducted to assess the reliability and variability of the results. Results With a 10\% fracture risk reduction, model A costs between \$8,850 and \$46,940 per quality-adjusted life-year (\$/QALY). Additionally, it proved most cost-effective in the age range between 61 and 81 years. The sensitivity analysis established that a reduction of ≥ 2.8\% is needed for prophylaxis to be definitely cost-effective. The cost-effectiveness at the secondary prevention level was most sensitive to the cost of the contralateral side's prophylaxis, the patient's age, and fracture treatment cost. For high-risk patients with no fracture history, the cost-effectiveness of a preventive strategy depends on their risk profile. In the baseline analysis, the incremental cost-effectiveness ratio at the primary prevention level varied between \$11,000/QALY and \$74,000/QALY, which is below the defined willingness to pay threshold. Conclusion Due to the high cost of hip fracture treatment and its increased morbidity, surgical prophylaxis strategies have demonstrated that they can significantly relieve the healthcare system. Various key assumptions facilitated the modeling, allowing for adequate room for uncertainty. Further research is needed to evaluate health-state-associated risks.},
  language  = {en}
}
@inproceedings{Alt2003,
  author    = {Alt, Helmut},
  title     = {Energiewirtschaftliche Bedeutung der Windenergie},
  series = {Fortschrittliche Energiewandlung und -anwendung 2003 : Tagung Stuttgart, 11. und 12. M{\"a}rz 2003. (VDI-Berichte ; 1746)},
  booktitle = {Fortschrittliche Energiewandlung und -anwendung 2003 : Tagung Stuttgart, 11. und 12. M{\"a}rz 2003. (VDI-Berichte ; 1746)},
  organization    = {Gesellschaft Energietechnik},
  isbn      = {3-18-091746-6},
  pages     = {447 -- 459},
  year      = {2003},
  language  = {de}
}
@inproceedings{Alt2000,
  author    = {Alt, Helmut},
  title     = {Stand der Durchleitungspraxis auf Basis des neuen Energiewirtschaftsgesetzes},
  series = {Energie und Umwelt 2000 : Fachkongreß und Ausstellung mit DBU-Statuskolloquium der Deutschen Bundesstiftung Umwelt: In situ-Bodenreaktor-Technologie, 29. bis 30. M{\"a}rz 2000 in Freiberg, Clemens-Winkler-Bau ; Tagungsband},
  booktitle = {Energie und Umwelt 2000 : Fachkongreß und Ausstellung mit DBU-Statuskolloquium der Deutschen Bundesstiftung Umwelt: In situ-Bodenreaktor-Technologie, 29. bis 30. M{\"a}rz 2000 in Freiberg, Clemens-Winkler-Bau ; Tagungsband},
  organization    = {Technische Universit{\"a}t <Freiberg>},
  pages     = {86 -- 88},
  year      = {2000},
  language  = {de}
}
@phdthesis{Alt1975,
  author    = {Alt, Helmut},
  title     = {Beitrag zur Spannungs-Blindleistungsregelung mit gesteuerten Netzkennlinien},
  address   = {Aachen},
  pages     = {163 S.},
  year      = {1975},
  language  = {de}
}
@article{Alt1976,
  author    = {Alt, Helmut},
  title     = {Spannungs-Blindleistungs-Regelung mit gesteuerten Netzkennlinien},
  series = {Elektrotechnische Zeitschrift : Ausgabe A, Zeitschrift f{\"u}r elektrische Energietechnik : ETZ},
  volume    = {97},
  journal   = {Elektrotechnische Zeitschrift : Ausgabe A, Zeitschrift f{\"u}r elektrische Energietechnik : ETZ},
  number    = {7},
  publisher = {VDE-Verlag},
  address   = {Wuppertal},
  issn      = {0302-265x},
  pages     = {441 -- 446},
  year      = {1976},
  language  = {de}
}
@article{Alt1989,
  author    = {Alt, Helmut},
  title     = {Sechsunddreißig Spielarten der Verrechung : die Behandlung von Tilgungs- und Zinszahlungen},
  series = {Frankfurter Zeitung : Blick durch die Wirtschaft : Zeitung f{\"u}r Finanzen, Steuern, Recht und Management},
  journal   = {Frankfurter Zeitung : Blick durch die Wirtschaft : Zeitung f{\"u}r Finanzen, Steuern, Recht und Management},
  pages     = {vom 12.9.1989},
  year      = {1989},
  language  = {de}
}
@inproceedings{Alt2004,
  author    = {Alt, Helmut},
  title     = {Energiewirtschaftliche Bedeutung der Windenergie im Stromerzeugungsmix},
  series = {Innovationen f{\"u}r Menschen : VDE-Kongress 2004, 18. - 20. Oktober 2004 in Berlin ; Bd. 1: Fachtagungsberichte der ITG - ETG},
  booktitle = {Innovationen f{\"u}r Menschen : VDE-Kongress 2004, 18. - 20. Oktober 2004 in Berlin ; Bd. 1: Fachtagungsberichte der ITG - ETG},
  publisher = {VDE-Verl.},
  address   = {Berlin [u.a.]},
  organization    = {Verband der Elektrotechnik, Elektronik, Informationstechnik},
  pages     = {551 -- 559},
  year      = {2004},
  language  = {de}
}
@article{Alt2001,
  author    = {Alt, Helmut},
  title     = {Energie: Der harte Wettbewerb erfordert eine g{\"u}nstige Strombeschaffung - Billiger Atomstrom wird aus dem Ausland importiert - Der Strommix im Netz l{\"a}sst sich nicht nach der Herkunft trennen "Gr{\"u}ner" Strom - ein Etikettenschwindel},
  series = {VDI-Nachrichten vom 15.6.2001},
  journal   = {VDI-Nachrichten vom 15.6.2001},
  pages     = {13},
  year      = {2001},
  language  = {de}
}
@article{Alt2007,
  author    = {Alt, Helmut},
  title     = {Leser: Es wurde nichts verschenkt},
  series = {Handelsblatt : Deutschlands Wirtschafts- und Finanzzeitung vom 5.1.2007},
  journal   = {Handelsblatt : Deutschlands Wirtschafts- und Finanzzeitung vom 5.1.2007},
  pages     = {18},
  year      = {2007},
  language  = {de}
}
@misc{Alt2004,
  author    = {Alt, Helmut},
  title     = {Netzeinspeisung aus zeitlich flukturierenden Quellen : Vortrag DPG : Fr{\"u}hjahrstagung des Arbeitskreises Energie (AKE) im Rahmen der Jahrestagung der DPG in M{\"u}nchen vom 22. bis 26. M{\"a}rz 2004},
  pages     = {1 -- 18},
  year      = {2004},
  language  = {de}
}
@misc{Alt2003,
  author    = {Alt, Helmut},
  title     = {Netzeinspeisung aus zeitlich fluktuativen Quellen (Wind und Photovoltaik) : Kurzfassung : Vortrag : 300. WE-Heraeus-Seminar Energie-Forschung : 26. bis 28. Mai 2003, Physikzentrum Bad Honnef, Elly H{\"o}lterhoff-B{\"o}cking-Stiftung},
  organization    = {Wilhelm und Else Heraeus-Stiftung},
  pages     = {1 -- 31},
  year      = {2003},
  language  = {de}
}
@misc{Alt2010,
  author    = {Alt, Helmut},
  title     = {Vom Studium der Kerntechnik zu Energie zwischen Wunsch und Wirklichkeit : [Vortrag : Verleihung der KTG-Ehrenmitgliedschaft, Berlin, November 2010]},
  pages     = {1 -- 15},
  year      = {2010},
  language  = {de}
}
@article{Alt1995,
  author    = {Alt, Helmut},
  title     = {Netzanschlußm{\"o}glichkeiten und energiewirtschaftliche Bewertung von Windkraftanlagen},
  series = {Elektrizit{\"a}tswirtschaft},
  volume    = {Jg. 94},
  journal   = {Elektrizit{\"a}tswirtschaft},
  number    = {H. 19},
  issn      = {0013-5496},
  pages     = {1224 -- 1234},
  year      = {1995},
  language  = {de}
}
@article{Alt2000,
  author    = {Alt, Helmut},
  title     = {Benchmark der Netznutzungspreise},
  series = {Energiewirtschaftliche Tagesfragen : et ; Zeitschrift f{\"u}r Energiewirtschaft, Recht, Technik und Umwelt},
  volume    = {Bd. 50},
  journal   = {Energiewirtschaftliche Tagesfragen : et ; Zeitschrift f{\"u}r Energiewirtschaft, Recht, Technik und Umwelt},
  number    = {H. 11},
  issn      = {0013-743X},
  pages     = {846 -- 850},
  year      = {2000},
  language  = {de}
}
@article{Alt1989,
  author    = {Alt, Helmut},
  title     = {Zinsberechnung nach dem Sparbuch-Modell},
  series = {Frankfurter Zeitung : Blick durch die Wirtschaft : Zeitung f{\"u}r Finanzen, Steuern, Recht und Management},
  journal   = {Frankfurter Zeitung : Blick durch die Wirtschaft : Zeitung f{\"u}r Finanzen, Steuern, Recht und Management},
  pages     = {vom 22.3.1989},
  year      = {1989},
  language  = {de}
}
@article{Alt1989,
  author    = {Alt, Helmut},
  title     = {Die Bedeutung des Effektivzinses in der Finanzwirtschaft},
  series = {Betriebs-Berater : BB : Beil. 14 Finanz-Berater},
  journal   = {Betriebs-Berater : BB : Beil. 14 Finanz-Berater},
  issn      = {0340-7926},
  pages     = {31 -- 32},
  year      = {1989},
  language  = {de}
}
@article{Alt1989,
  author    = {Alt, Helmut},
  title     = {Einfluß der Kontof{\"u}hrungsmodelle auf den Effektivzins und die Restschuld bei Annuit{\"a}tendarlehen},
  series = {Betriebs-Berater : BB : Beil. 14 Finanz-Berater},
  journal   = {Betriebs-Berater : BB : Beil. 14 Finanz-Berater},
  issn      = {0340-7926},
  pages     = {32 -- 37},
  year      = {1989},
  language  = {de}
}
@article{Alt2002,
  author    = {Alt, Helmut},
  title     = {Belieferung von Kunden in fremden Netzgebieten},
  series = {EW : das Magazin f{\"u}r die Energie-Wirtschaft},
  volume    = {Bd. 101},
  journal   = {EW : das Magazin f{\"u}r die Energie-Wirtschaft},
  number    = {H. 1/2},
  issn      = {0013-5496},
  pages     = {26 -- 35},
  year      = {2002},
  language  = {de}
}
@article{Alt2005,
  author    = {Alt, Helmut},
  title     = {Wunschphantasie eines eingefleischten Kernenergiegegners : zur Rede von Bundesumweltminister J{\"u}rgen Trittin auf dem VDEW-Kongress 2005 "Die Energieversorgung der Zukunft"},
  series = {EW : das Magazin f{\"u}r die Energie-Wirtschaft},
  volume    = {Bd. 104},
  journal   = {EW : das Magazin f{\"u}r die Energie-Wirtschaft},
  number    = {H. 17/18},
  issn      = {0013-5496},
  pages     = {7},
  year      = {2005},
  language  = {de}
}