@article{ScheerWolf2014, author = {Scheer, Nico and Wolf, C. Roland}, title = {Genetically humanized mouse models of drug metabolizing enzymes and transporters and their applications}, series = {Xenobiotica}, volume = {44}, journal = {Xenobiotica}, number = {2}, publisher = {Taylor \& Francis}, address = {Abingdon}, issn = {1366-5928}, doi = {10.3109/00498254.2013.815831}, pages = {96 -- 108}, year = {2014}, abstract = {1. Drug metabolizing enzymes and transporters play important roles in the absorption, metabolism, tissue distribution and excretion of various compounds and their metabolites and thus can significantly affect their efficacy and safety. Furthermore, they can be involved in drug-drug interactions which can result in adverse responses, life-threatening toxicity or impaired efficacy. Significant species differences in the interaction of compounds with drug metabolizing enzymes and transporters have been described. 2. In order to overcome the limitation of animal models in accurately predicting human responses, a large variety of mouse models humanized for drug metabolizing enzymes and to a lesser extent drug transporters have been created. 3. This review summarizes the literature describing these mouse models and their key applications in studying the role of drug metabolizing enzymes and transporters in drug bioavailability, tissue distribution, clearance and drug-drug interactions as well as in human metabolite testing and risk assessment. 4. Though such humanized mouse models have certain limitations, there is great potential for their use in basic research and for testing and development of new medicines. These limitations and future potentials will be discussed.}, language = {en} } @article{ScheerWolf2013, author = {Scheer, Nico and Wolf, C. Roland}, title = {Xenobiotic receptor humanized mice and their utility}, series = {Drug Metabolism Reviews}, journal = {Drug Metabolism Reviews}, number = {1}, publisher = {Taylor \& Francis}, address = {London}, issn = {1097-9883}, doi = {10.3109/03602532.2012.738687}, pages = {110 -- 121}, year = {2013}, language = {en} } @book{Scherer1989, author = {Scherer, Ulrich W.}, title = {Untersuchungen zur Synthese und chemischen Charakterisierung sehr schwerer Elemente / Ulrich W. Scherer}, publisher = {Gesellschaft f{\"u}r Schwerionenforschung mbH}, address = {Darmstadt}, pages = {123 S.}, year = {1989}, language = {de} } @book{Scherer2001, author = {Scherer, Ulrich W.}, title = {Ultraschnelle Analytik radioaktiver Wirkstoffe : Abschlußbericht zu Nr. 3.2 und Anlage 2 BNBest-BMBF 98 ; Laufzeit des Vorhabens: 1.9.1999 -28.2.2001 / Zuwendungsempf{\"a}nger: Ulrich W. Scherer}, publisher = {Universit{\"a}tsbibliothek u. Technische Informationsbibliothek}, address = {Hannover}, pages = {Elektronische Ressource}, year = {2001}, language = {de} } @article{Scherer1997, author = {Scherer, Ulrich W.}, title = {Zur Radiopharmazie kardialer und kardiovaskul{\"a}rer Radiopharmazeutika}, series = {Kardiologische Nuklearmedizin / G. H{\"o}r [Hrsg.]}, journal = {Kardiologische Nuklearmedizin / G. H{\"o}r [Hrsg.]}, publisher = {ecomed}, address = {Landsberg}, isbn = {3-609-62970-3}, pages = {27 -- 42}, year = {1997}, language = {de} } @article{Scherer2006, author = {Scherer, Ulrich W.}, title = {Controlled ion track etching / J. George; M. Irkens ; S. Neumann ; U. W. Scherer ; A. Srivastava ; D. Sinha ; D. Fink}, series = {Radiation Effects and Defects in Solids. 161 (2006), H. 3}, journal = {Radiation Effects and Defects in Solids. 161 (2006), H. 3}, pages = {161 -- 175}, year = {2006}, language = {en} } @article{SchererBaltenspergerAmmannetal.1993, author = {Scherer, Ulrich W. and Baltensperger, Urs and Ammann, Markus and Bochert, Ulrich K.}, title = {Use of 13N for Studies of the Selective Reduction of NO by NH3 over Vanadia/Titania Catalyst at Very Low Reactant Concentrations / Urs Baltensperger, Markus Ammann, Ulrich K. Bochert, Bernd Eichler, Heinz W. G{\"a}ggeler, Dieter T. Jost, Joseph A. Kovacs, An}, series = {Journal of Physical Chemistry. 97 (1993)}, journal = {Journal of Physical Chemistry. 97 (1993)}, isbn = {0022-3654}, pages = {12325 -- 12330}, year = {1993}, language = {en} } @article{SchererBruechleBrueggeretal.1990, author = {Scherer, Ulrich W. and Br{\"u}chle, W. and Br{\"u}gger, M. and Frink, C.}, title = {Reactions of 40Ar with 233U,,235U, and 238U at the Barrier / U.W. Scherer, W. Br{\"u}chle, M. Br{\"u}gger, C. Frink, H. G{\"a}ggeler, G. Herrmann, J.V. Kratz, K.J. Moody, M. Sch{\"a}del, K. S{\"u}mmerer, N. Trautmann, G. Wirth}, series = {Zeitschrift f{\"u}r Physik A Hadrons and Nuclei. 335 (1990), H. 4}, journal = {Zeitschrift f{\"u}r Physik A Hadrons and Nuclei. 335 (1990), H. 4}, isbn = {0939-7922}, pages = {421 -- 430}, year = {1990}, language = {en} } @article{SchererBruechleSchaedeletal.1988, author = {Scherer, Ulrich W. and Br{\"u}chle, W. and Sch{\"a}del, M. and Kratz, J. V.}, title = {The Hydration Enthalpies of Md3+ and Lr3+ / W. Br{\"u}chle, M. Sch{\"a}del, U.W. Scherer, J.V. Kratz, K.E. Gregorich, D. Lee, M. Nurmia, R.M. Chasteler, H.L. Hall, R.A. Henderson, D.C. Hoffman}, series = {Inorganica Chimica Acta. 146 (1988), H. 2}, journal = {Inorganica Chimica Acta. 146 (1988), H. 2}, isbn = {0020-1693}, pages = {267 -- 276}, year = {1988}, language = {en} } @article{SchererGoberKratzetal.1992, author = {Scherer, Ulrich W. and Gober, M. K. and Kratz, J. V. and Zimmermann, H. P.}, title = {Chemical Properties of Element 105 in Aqueous Solution: Extractions into Diisobutylcarbinol / M.K. Gober, J.V. Kratz, H.P. Zimmermann, M. Sch{\"a}del, W. Br{\"u}chle, E. Schimpf, K.E. Gregorich, A. T{\"u}rler, N.J. Hannink, K.R. Czerwinski, B. Kadkhodayan, D.M. Lee,}, series = {Radiochimica Acta. 57 (1992)}, journal = {Radiochimica Acta. 57 (1992)}, isbn = {0033-8230}, pages = {77 -- 84}, year = {1992}, language = {en} } @article{SchererGaeggelerJostetal.1992, author = {Scherer, Ulrich W. and G{\"a}ggeler, H. W. and Jost, D. T. and Kovacs, J.}, title = {Gas Phase Chromatography Experiments with Bromides of Tantalum and Element 105 / H.W. G{\"a}ggeler, D.T. Jost, J. Kovacs, U.W. Scherer, A. Weber, D. Vermeulen, A. T{\"u}rler, K.E. Gregorich, R.A. Henderson, K.R. Czerwinski, B. Kadkhodayan, D.M. Lee, M. Nurmia, D.}, series = {Radiochimica Acta. 57 (1992)}, journal = {Radiochimica Acta. 57 (1992)}, isbn = {0033-8230}, pages = {93 -- 100}, year = {1992}, language = {en} } @article{SchererGaeggelerJostetal.1989, author = {Scherer, Ulrich W. and G{\"a}ggeler, H. W. and Jost, D. T. and T{\"u}rler, A.}, title = {Cold Fusion Reactions with 48Ca / H.W. G{\"a}ggeler, D.T. Jost, A. T{\"u}rler, P. Armbruster, W. Br{\"u}chle, H. Folger, F.P. Heßberger, S. Hofmann, G. M{\"u}nzenberg, V. Ninov, W. Reisdorf, M. Sch{\"a}del, K. S{\"u}mmerer, J.V. Kratz, U. Scherer, M.E. Leino}, series = {Nuclear Physics A . 502 (1989), H. 1}, journal = {Nuclear Physics A . 502 (1989), H. 1}, isbn = {0375-9474}, pages = {561 -- 570}, year = {1989}, language = {en} } @article{SchererHessbergerGaeggeleretal.1989, author = {Scherer, Ulrich W. and Heßberger, F. P. and G{\"a}ggeler, H. W. and Armbruster, P.}, title = {The New Nuclide 225U / F.P. Heßberger, H. G{\"a}ggeler, P. Armbruster, W. Br{\"u}chle, H. Folger, S. Hofmann, D. Jost, J.V. Kratz, M.E. Leino, G. M{\"u}nzenberg, V. Ninov, M. Sch{\"a}del, U.W. Scherer, K. S{\"u}mmerer, A. T{\"u}rler, D. Ackerman}, series = {Zeitschrift f{\"u}r Physik A Hadrons and Nuclei. 333 (1989), H. 1}, journal = {Zeitschrift f{\"u}r Physik A Hadrons and Nuclei. 333 (1989), H. 1}, isbn = {0939-7922}, pages = {111 -- 112}, year = {1989}, language = {en} } @article{SchererHoer1997, author = {Scherer, Ulrich W. and H{\"o}r, G.}, title = {Kompartimentmodelle zur Quantifizierung des myokardialen Stoffwechsels mit PET / U. W. Scherer, G. H{\"o}r}, series = {Kardiologische Nuklearmedizin / G. H{\"o}r [Hrsg.]}, journal = {Kardiologische Nuklearmedizin / G. H{\"o}r [Hrsg.]}, publisher = {ecomed}, address = {Landsberg}, isbn = {3-609-62970-3}, pages = {179 -- 189}, year = {1997}, language = {de} } @article{SchererHoer1997, author = {Scherer, Ulrich W. and H{\"o}r, G.}, title = {Artifacts and Pitfalls in FDG-PET Whole-Body Scans / U.W. Scherer, G. H{\"o}r}, series = {Radionuclides for Mammary Gland - Current Status and Future Aspects / G. S. Limouris [Hrsg.]}, journal = {Radionuclides for Mammary Gland - Current Status and Future Aspects / G. S. Limouris [Hrsg.]}, publisher = {Mediterra Publishers}, address = {Athen}, isbn = {960-85227-6-5}, pages = {37 -- 42}, year = {1997}, language = {en} } @article{SchererHoerHertel1998, author = {Scherer, Ulrich W. and H{\"o}r, G. and Hertel, A.}, title = {Positronen-Emissions-Tomographie des Herzens / G. H{\"o}r, A. Hertel, U. W. Scherer}, series = {Herzerkrankungen und Interventionsm{\"o}glichkeiten / F. Unger [Hrsg.]}, journal = {Herzerkrankungen und Interventionsm{\"o}glichkeiten / F. Unger [Hrsg.]}, publisher = {Springer}, address = {Berlin}, isbn = {3-540-62916-5}, pages = {236 -- 263}, year = {1998}, language = {de} } @article{SchererHoerKranertetal.1998, author = {Scherer, Ulrich W. and H{\"o}r, G. and Kranert, W. T. and Maul, F. D.}, title = {Gated Metabolic Positron Emission Tomography (GAPET) of Myocardium: 18F-FDG/PET to optimize Recognition of Myocardial Hibernation / G. H{\"o}r, W.T. Kranert, F.D. Maul, O. Schr{\"o}der, A. Karimian-Tatriz, O. Geb, R.P. Baum, U.W. Scherer}, series = {Nuclear Medicine Communications. 19 (1998)}, journal = {Nuclear Medicine Communications. 19 (1998)}, isbn = {0143-3636}, pages = {535 -- 545}, year = {1998}, language = {en} } @article{SchererJacobiCastilloetal.2009, author = {Scherer, Ulrich W. and Jacobi, M. and Castillo, J. and Foerstel, D. H.}, title = {Ultra-low-level measurements of 3H and 14C in wines and champagne / Scherer, U. W. ; Jacobi, M. ; Castillo, J. ; Foerstel, D. H.}, series = {Radiation effects and defects in solids. 164 (2009), H. 5-6}, journal = {Radiation effects and defects in solids. 164 (2009), H. 5-6}, isbn = {1042-0150}, pages = {382 -- 385}, year = {2009}, language = {en} } @article{SchererKratzGoberetal.1992, author = {Scherer, Ulrich W. and Kratz, J. V. and Gober, M. K. and Zimmermann, H. P.}, title = {New nuclide 263 105 / J.V. Kratz, M.K. Gober, H.P. Zimmermann, M. Sch{\"a}del, W. Br{\"u}chle, E. Schimpf, K.E. Gregorich, A. T{\"u}rler, N.J. Hannink, K.R. Czerwinski, B. Kadkhodayan, D.M. Lee, M.J. Nurmia, D.C. Hoffman, H. G{\"a}ggeler, D. Jost, U.W. Scherer, A. Weber}, series = {Physical Review C . 45 (1992)}, journal = {Physical Review C . 45 (1992)}, pages = {1064 -- 1069}, year = {1992}, language = {en} } @article{SchererKratzSchaedeletal.1988, author = {Scherer, Ulrich W. and Kratz, J. V. and Sch{\"a}del, M. and Br{\"u}chle, W.}, title = {Lawrencium Chemistry: No Evidence for Oxidation States Lower than 3+ in Aqueous Solution / U.W. Scherer, J.V. Kratz, M. Sch{\"a}del, W. Br{\"u}chle, K.E. Gregorich, R.A. Henderson, D. Lee, M. Nurmia, D.C. Hoffman}, series = {Inorganica Chimica Acta. 146 (1988)}, journal = {Inorganica Chimica Acta. 146 (1988)}, isbn = {0020-1693}, pages = {249 -- 254}, year = {1988}, language = {en} }