@article{WeckesserHufnagelZiemonsetal.1997, author = {Weckesser, Matthias and Hufnagel, Andreas and Ziemons, Karl and Grießmeier, Martin and Sonnenberg, Frank and Hackl{\"a}nder, Thomas and Langen, Karl-J. and Holschbach, Markus and Elger, Christian E. and M{\"u}ller-G{\"a}rtner, Hans-W.}, title = {Effect of partial volume correction on muscarinic cholinergic receptor imaging with single-photon emission tomography in patients with temporal lobe epilepsy}, series = {European Journal of Nuclear Medicine}, volume = {24}, journal = {European Journal of Nuclear Medicine}, number = {9}, isbn = {1619-7089}, pages = {1156 -- 1161}, year = {1997}, abstract = {Animal experiments and preliminary results in humans have indicated alterations of hippocampal muscarinic acetylcholine receptors (mAChR) in temporal lobe epilepsy. Patients with temporal lobe epilepsy often present with a reduction in hippocampal volume. The aim of this study was to investigate the influence of hippocampal atrophy on the quantification of mAChR with single photon emission tomography (SPET) in patients with temporal lobe epilepsy. Cerebral uptake of the muscarinic cholinergic antagonist [123I]4-iododexetimide (IDex) was investigated by SPET in patients suffering from temporal lobe epilepsy of unilateral (n=6) or predominantly unilateral (n=1) onset. Regions of interest were drawn on co-registered magnetic resonance images. Hippocampal volume was determined in these regions and was used to correct the SPET results for partial volume effects. A ratio of hippocampal IDex binding on the affected side to that on the unaffected side was used to detect changes in muscarinic cholinergic receptor density. Before partial volume correction a decrease in hippocampal IDex binding on the focus side was found in each patient. After partial volume no convincing differences remained. Our results indicate that the reduction in hippocampal IDex binding in patients with epilepsy is due to a decrease in hippocampal volume rather than to a decrease in receptor concentration.}, language = {en} } @article{WeckesserGriessmeierSchmidtetal.1998, author = {Weckesser, Martin and Grießmeier, Martin and Schmidt, Daniela and Sonnenberg, Frank and Ziemons, Karl and Kemna, Lars and Holschbach, Marcus and Langen, Karl-J. and M{\"u}ller-G{\"a}rtner, Hans-W.}, title = {Iodine-123 α-methyl tyrosine single-photon emission tomography of cerebral gliomas: standardised evaluation of tumour uptake and extent}, series = {European Journal of Nuclear Medicine}, volume = {25}, journal = {European Journal of Nuclear Medicine}, number = {2}, isbn = {1619-7089}, pages = {150 -- 156}, year = {1998}, abstract = {Single-photon emission tomography (SPET) with the amino acid analogue l-3-[123I]iodo-α-methyl tyrosine (IMT) is helpful in the diagnosis and monitoring of cerebral gliomas. Radiolabelled amino acids seem to reflect tumour infiltration more specifically than conventional methods like magnetic resonance imaging and computed tomography. Automatic tumour delineation based on maximal tumour uptake may cause an overestimation of mean tumour uptake and an underestimation of tumour extension in tumours with circumscribed peaks. The aim of this study was to develop a program for tumour delineation and calculation of mean tumour uptake which takes into account the mean background activity and is thus optimised to the problem of tumour definition in IMT SPET. Using the frequency distribution of pixel intensities of the tomograms a program was developed which automatically detects a reference brain region and draws an isocontour region around the tumour taking into account mean brain radioactivity. Tumour area and tumour/brain ratios were calculated. A three-compartment phantom was simulated to test the program. The program was applied to IMT SPET studies of 20 patients with cerebral gliomas and was compared to the results of manual analysis by three different investigators. Activity ratios and chamber extension of the phantom were correctly calculated by the automatic analysis. A method based on image maxima alone failed to determine chamber extension correctly. Manual region of interest analysis in patient studies resulted in a mean inter-observer standard deviation of 8.7\%±6.1\% (range 2.7\%-25.0\%). The mean value of the results of the manual analysis showed a significant correlation to the results of the automatic analysis (r = 0.91, P<0.0001 for the uptake ratio; r = 0.87, P<0.0001 for the tumour area). We conclude that the algorithm proposed simplifies the calculation of uptake ratios and may be used for observer-independent evaluation of IMT SPET studies. Three-dimensional tumour recognition and transfer to co-registered morphological images based on this program may be useful for the planning of surgical and radiation treatment.}, language = {en} } @inproceedings{WeberTersteggeHallingetal.1995, author = {Weber, S. and Terstegge, Andreas and Halling, H. and Herzog, H. and Reinartz, R. and Reinhart, P. and Rongen, F. and M{\"u}ller-G{\"a}rtner, H.-W.}, title = {The design of an animal PET: flexible geometry for achieving optimal spatial resolution or high sensitivity}, series = {Conference record / 1995 IEEE Nuclear Science Symposium and Medical Imaging, October 21 - 28, 1995, San Francisco ; vol. 2}, booktitle = {Conference record / 1995 IEEE Nuclear Science Symposium and Medical Imaging, October 21 - 28, 1995, San Francisco ; vol. 2}, publisher = {IEEE}, address = {Piscataway, NJ}, organization = {Institute of Electrical and Electronics Engineers}, isbn = {078033180X ; 0780331818 ; 0780331826}, pages = {1002 -- 1005}, year = {1995}, language = {en} } @inproceedings{WeberTersteggeEngelsetal.1996, author = {Weber, S. and Terstegge, Andreas and Engels, R. and Herzog, H. and Reinartz, R. and Reinhart, P. and Rongen, F. and M{\"u}ller-G{\"a}rtner, H. W. and Halling, H.}, title = {The KFA TierPET: performance characteristics and measurements}, series = {Conference record / 1996 IEEE Nuclear Science Symposium [and Medical Imaging], November 2 - 9, 1996, Anaheim, California ; vol. 2}, booktitle = {Conference record / 1996 IEEE Nuclear Science Symposium [and Medical Imaging], November 2 - 9, 1996, Anaheim, California ; vol. 2}, publisher = {IEEE}, address = {Piscataway, NJ}, organization = {Institute of Electrical and Electronics Engineers}, isbn = {0-7803-3534-1}, issn = {1082-3654}, pages = {1117 -- 1119}, year = {1996}, language = {en} } @inproceedings{WeberPorschenDietzeletal.1978, author = {Weber, Hans-Joachim and Porschen, W. and Dietzel, F. and [u.a.],}, title = {In vivo analysis of the influence of combined hyperthermia and gamma irradiation on euoxic and hypoxic tumor cells}, series = {Cancer therapy by hyperthermia and radiation : [proceedings of the 2. International Symposium on Cancer Therapy by Hyperthermia and Radiation, Essen, 2.-4.6.1977]}, booktitle = {Cancer therapy by hyperthermia and radiation : [proceedings of the 2. International Symposium on Cancer Therapy by Hyperthermia and Radiation, Essen, 2.-4.6.1977]}, editor = {Streffer, Christian}, publisher = {Urban and Schwarzenberg}, address = {Baltimore ; Munich [u.a.]}, isbn = {0-8067-1701-7}, pages = {276 -- 277}, year = {1978}, language = {en} } @article{WeberMoRamakrishna2006, author = {Weber, Hans-Joachim and Mo, Xiumei and Ramakrishna, S.}, title = {PCL-PGLA composite tubular scaffold preparation and biocompatibility investigation / X. Mo, H.-J. Weber, S. Ramakrishna}, series = {The International journal of artificial organs. 29 (2006), H. 8}, journal = {The International journal of artificial organs. 29 (2006), H. 8}, publisher = {-}, pages = {790 -- 799}, year = {2006}, language = {en} } @article{WeberMoChen2007, author = {Weber, Hans-Joachim and Mo, Xiumei and Chen, Zonggang}, title = {Electrospun nanofibers of collagen-chitosan and P(LLA-CL) for tissue engineering / Mo Xiumei, Chen Zonggang, Hans J. Weber}, series = {Frontiers of materials science in China. 1 (2007), H. 1}, journal = {Frontiers of materials science in China. 1 (2007), H. 1}, publisher = {-}, isbn = {1673-7377}, pages = {20 -- 23}, year = {2007}, language = {en} } @article{WeberMo2004, author = {Weber, Hans-Joachim and Mo, Xiumei}, title = {Electrospinning P(LLA-CL) nanofiber: a tubular scaffold fabrication with circumferential alignment / Xiumei Mo, Hans-Joachim Weber}, series = {Contributions from 6th Austrian Polymer Meeting : Vienna, Austria, September 15 - 17, 2003 / Symposium ed.: W. H. Binder}, journal = {Contributions from 6th Austrian Polymer Meeting : Vienna, Austria, September 15 - 17, 2003 / Symposium ed.: W. H. Binder}, publisher = {Wiley-VCH}, address = {Weinheim}, pages = {413 -- 416}, year = {2004}, language = {en} } @article{WeberLacoKunetal.2009, author = {Weber, Hans-Joachim and Laco, Filip and Kun, Ma and Ramakrishna, S.}, title = {The dose effect of human bone marrow-derived mesenchymal stem cells on epidermal development in organotypic co-culture / Laco, Filip ; Kun, Ma ; Weber, Hans Joachim ; Ramakrishna, S. ; Chan, Casey K.}, series = {Journal of Dermatological Science. 55 (2009), H. 3}, journal = {Journal of Dermatological Science. 55 (2009), H. 3}, isbn = {0923-1811}, pages = {150 -- 160}, year = {2009}, language = {en} } @book{WeberKaminskyKallweitetal.2005, author = {Weber, Hans-Joachim and Kaminsky, Radoslav and Kallweit, Stephan and Simons, Antoine}, title = {PIV measurements with high temporal resolution behind artificial heart valves}, pages = {9 S.}, year = {2005}, language = {en} } @article{WeberHekmatZimmermannetal.2004, author = {Weber, Hans-Joachim and Hekmat, K. and Zimmermann, T. and Kampe, S.}, title = {Impact of tranexamic acid vs. aprotinin on blood loss and transfusion requirements after cardiopulmonary bypass: a prospective, randomised, double-blind trial / Hekmat, K. ; Zimmermann, T. ; Kampe, S. ; Kasper, S. M. ; Weber, H. J. ; Geissler, H. J. ; Meh}, series = {Current Medical Research and Opinion. 20 (2004), H. 1}, journal = {Current Medical Research and Opinion. 20 (2004), H. 1}, isbn = {0300-7995}, pages = {121 -- 126}, year = {2004}, language = {en} } @article{WeberBhujuChandraetal.2004, author = {Weber, Hans-Joachim and Bhuju, S. and Chandra, S. and Mo, X.}, title = {Fabrication of biodegradable nanofibers for tubular scaffolds in regenerative medicine / Weber, H.-J. ; Bhuju, S. ; Chandra, S. ; Mo, X.}, series = {Biomedizinische Technik. 49 (2004), H. Erg.-Bd. 2, Teil 2}, journal = {Biomedizinische Technik. 49 (2004), H. Erg.-Bd. 2, Teil 2}, pages = {1016 -- 1017}, year = {2004}, language = {en} } @incollection{Weber1998, author = {Weber, Hans-Joachim}, title = {Applied physics of compressible and incompressible fluids}, series = {Critical care nephrology / [Hrsg.:] Claudio Ronco and Rinaldo Bellomo}, booktitle = {Critical care nephrology / [Hrsg.:] Claudio Ronco and Rinaldo Bellomo}, publisher = {Springer}, address = {Dordrecht}, isbn = {978-94-010-6306-7}, pages = {63 -- 84}, year = {1998}, language = {en} } @article{WarmerWagnerSchoeningetal.2015, author = {Warmer, Johannes and Wagner, Patrick and Sch{\"o}ning, Michael Josef and Kaul, Peter}, title = {Detection of triacetone triperoxide using temperature cycled metal-oxide semiconductor gas sensors}, series = {Physica status solidi (a)}, volume = {212}, journal = {Physica status solidi (a)}, number = {6}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1862-6319}, doi = {10.1002/pssa.201431882}, pages = {1289 -- 1298}, year = {2015}, language = {en} } @article{WarerkarSchmitzGoettscheetal.2011, author = {Warerkar, Shashikant and Schmitz, Stefan and G{\"o}ttsche, Joachim and Hoffschmidt, Bernhard and Reißel, Martin and Tamme, Rainer}, title = {Air-Sand Heat Exchanger for High-Temperature Storage}, series = {Journal of Solar Energy Engineering. 133 (2011), H. 2}, journal = {Journal of Solar Energy Engineering. 133 (2011), H. 2}, publisher = {ASME}, address = {New York}, isbn = {0199-6231}, pages = {021010}, year = {2011}, language = {en} } @article{WangKrauseBlocketal.2003, author = {Wang, J. and Krause, R. and Block, K. and Musameh, M. and Mulchandani, A. and Sch{\"o}ning, Michael Josef}, title = {Flow injection amperometric detection of OP nerve agents based on organophosphorus-hydrolase biosensor detector}, series = {Biosensors \& Bioelectronics. 18 (2003), H. 2-3}, journal = {Biosensors \& Bioelectronics. 18 (2003), H. 2-3}, isbn = {0956-5663}, pages = {255 -- 260}, year = {2003}, language = {en} } @misc{WandreyBiselliSchroederetal.1999, author = {Wandrey, Christian and Biselli, Manfred and Schr{\"o}der, Bernd and Schmoll, Hans-Joachim}, title = {Culturing cells on macroporous glass carriers coated with gelatin, extracellular matrix protein and stromal cells}, pages = {1 -- 12}, year = {1999}, language = {en} } @article{WaldvogelRitzmannFreyleretal.2021, author = {Waldvogel, Janice and Ritzmann, Ramona and Freyler, Kathrin and Helm, Michael and Monti, Elena and Albracht, Kirsten and St{\"a}udle, Benjamin and Gollhofer, Albert and Narici, Marco}, title = {The Anticipation of Gravity in Human Ballistic Movement}, series = {Frontiers in Physiology}, journal = {Frontiers in Physiology}, publisher = {Frontiers}, address = {Lausanne}, issn = {1664-042X}, doi = {10.3389/fphys.2021.614060}, year = {2021}, abstract = {Stretch-shortening type actions are characterized by lengthening of the pre-activated muscle-tendon unit (MTU) in the eccentric phase immediately followed by muscle shortening. Under 1 g, pre-activity before and muscle activity after ground contact, scale muscle stiffness, which is crucial for the recoil properties of the MTU in the subsequent push-off. This study aimed to examine the neuro-mechanical coupling of the stretch-shortening cycle in response to gravity levels ranging from 0.1 to 2 g. During parabolic flights, 17 subjects performed drop jumps while electromyography (EMG) of the lower limb muscles was combined with ultrasound images of the gastrocnemius medialis, 2D kinematics and kinetics to depict changes in energy management and performance. Neuro-mechanical coupling in 1 g was characterized by high magnitudes of pre-activity and eccentric muscle activity allowing an isometric muscle behavior during ground contact. EMG during pre-activity and the concentric phase systematically increased from 0.1 to 1 g. Below 1 g the EMG in the eccentric phase was diminished, leading to muscle lengthening and reduced MTU stretches. Kinetic energy at take-off and performance were decreased compared to 1 g. Above 1 g, reduced EMG in the eccentric phase was accompanied by large MTU and muscle stretch, increased joint flexion amplitudes, energy loss and reduced performance. The energy outcome function established by linear mixed model reveals that the central nervous system regulates the extensor muscles phase- and load-specifically. In conclusion, neuro-mechanical coupling appears to be optimized in 1 g. Below 1 g, the energy outcome is compromised by reduced muscle stiffness. Above 1 g, loading progressively induces muscle lengthening, thus facilitating energy dissipation.}, language = {en} } @article{WaldvogelFreylerHelmetal.2023, author = {Waldvogel, Janice and Freyler, Kathrin and Helm, Michael and Monti, Elena and St{\"a}udle, Benjamin and Gollhofer, Albert and Narici, Marco V. and Ritzmann, Ramona and Albracht, Kirsten}, title = {Changes in gravity affect neuromuscular control, biomechanics, and muscle-tendon mechanics in energy storage and dissipation tasks}, series = {Journal of Applied Physiology}, volume = {134}, journal = {Journal of Applied Physiology}, number = {1}, publisher = {American Physiological Society}, address = {Bethesda, Md.}, issn = {1522-1601 (Onlineausgabe)}, doi = {10.1152/japplphysiol.00279.2022}, pages = {190 -- 202}, year = {2023}, abstract = {This study evaluates neuromechanical control and muscle-tendon interaction during energy storage and dissipation tasks in hypergravity. During parabolic flights, while 17 subjects performed drop jumps (DJs) and drop landings (DLs), electromyography (EMG) of the lower limb muscles was combined with in vivo fascicle dynamics of the gastrocnemius medialis, two-dimensional (2D) kinematics, and kinetics to measure and analyze changes in energy management. Comparisons were made between movement modalities executed in hypergravity (1.8 G) and gravity on ground (1 G). In 1.8 G, ankle dorsiflexion, knee joint flexion, and vertical center of mass (COM) displacement are lower in DJs than in DLs; within each movement modality, joint flexion amplitudes and COM displacement demonstrate higher values in 1.8 G than in 1 G. Concomitantly, negative peak ankle joint power, vertical ground reaction forces, and leg stiffness are similar between both movement modalities (1.8 G). In DJs, EMG activity in 1.8 G is lower during the COM deceleration phase than in 1 G, thus impairing quasi-isometric fascicle behavior. In DLs, EMG activity before and during the COM deceleration phase is higher, and fascicles are stretched less in 1.8 G than in 1 G. Compared with the situation in 1 G, highly task-specific neuromuscular activity is diminished in 1.8 G, resulting in fascicle lengthening in both movement modalities. Specifically, in DJs, a high magnitude of neuromuscular activity is impaired, resulting in altered energy storage. In contrast, in DLs, linear stiffening of the system due to higher neuromuscular activity combined with lower fascicle stretch enhances the buffering function of the tendon, and thus the capacity to safely dissipate energy.}, language = {en} } @inproceedings{WagnerYoshinobuSchoening2008, author = {Wagner, Torsten and Yoshinobu, T. and Sch{\"o}ning, Michael Josef}, title = {Light-addressable potentiometric sensor as semiconductor-based sensor platform for (bio-) chemical sensing}, series = {Armenian Journal of Physics}, booktitle = {Armenian Journal of Physics}, issn = {1829-1171}, pages = {99 -- 103}, year = {2008}, language = {en} }