@article{WincklerKruegerSchnitzleretal.2014, author = {Winckler, Silvia and Krueger, Rolf and Schnitzler, Thomas and Zang, Werner and Fischer, Rainer and Biselli, Manfred}, title = {A sensitive monitoring system for mammalian cell cultivation processes: a PAT approach}, series = {Bioprocess and biosystems engineering}, volume = {37}, journal = {Bioprocess and biosystems engineering}, number = {5}, publisher = {Springer}, address = {Berlin, Heidelberg}, issn = {1615-7591 (Print) 1615-7605 (Online)}, doi = {10.1007/s00449-013-1062-8}, pages = {901 -- 912}, year = {2014}, abstract = {Biopharmaceuticals such as antibodies are produced in cultivated mammalian cells, which must be monitored to comply with good manufacturing practice. We, therefore, developed a fully automated system comprising a specific exhaust gas analyzer, inline analytics and a corresponding algorithm to precisely determine the oxygen uptake rate, carbon dioxide evolution rate, carbon dioxide transfer rate, transfer quotient and respiratory quotient without interrupting the ongoing cultivation, in order to assess its reproducibility. The system was verified using chemical simulation experiments and was able to measure the respiratory activity of hybridoma cells and DG44 cells (derived from Chinese hamster ovary cells) with satisfactory results at a minimum viable cell density of ~2.0 × 10⁵ cells ml⁻¹. The system was suitable for both batch and fed-batch cultivations in bubble-aerated and membrane-aerated reactors, with and without the control of pH and dissolved oxygen.}, language = {en} } @article{WilsonBlomeLaFave1996, author = {Wilson, Thomas L and Blome, Hans-Joachim and LaFave, Norman}, title = {Astrophysical Cosmology Using a Lunar Ligo}, series = {Engineering, construction, and operations in space V : proceedings of the Fifth International Conference on Space '96, Albuquerque, New Mexico, June 1-6, 1996 / sponsored by Aerospace Division of the American Society of Civil Engineers ... [et al.]; edite}, journal = {Engineering, construction, and operations in space V : proceedings of the Fifth International Conference on Space '96, Albuquerque, New Mexico, June 1-6, 1996 / sponsored by Aerospace Division of the American Society of Civil Engineers ... [et al.]; edite}, publisher = {The Society}, address = {New York}, isbn = {0-7844-0177-2}, pages = {861 -- 863}, year = {1996}, language = {en} } @article{WilsonBlome2009, author = {Wilson, T. L. and Blome, Hans-Joachim}, title = {The Pioneer anomaly and a rotating G{\"o}del universe}, series = {Advances in Space Research}, volume = {44}, journal = {Advances in Space Research}, number = {11}, isbn = {0273-1177}, pages = {1345 -- 1353}, year = {2009}, language = {en} } @article{WilsonWilsonScheeretal.2017, author = {Wilson, Ian D. and Wilson, Claire E. and Scheer, Nico and Dickie, A.P. and Schreiter, K. and Wilson, E. M. and Riley, R. J. and Wehr, R. and Bial, J.}, title = {The Pharmacokinetics and Metabolism of Lumiracoxib in Chimeric Humanized and Murinized FRG Mice}, series = {Biochemical pharmacology}, volume = {Volume 135}, journal = {Biochemical pharmacology}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1873-2968}, doi = {10.1016/j.bcp.2017.03.015}, pages = {139 -- 150}, year = {2017}, language = {en} } @article{WilsonDickieSchreiteretal.2018, author = {Wilson, C. E. and Dickie, A. P. and Schreiter, K. and Wehr, R. and Wilson, E. M. and Bial, J. and Scheer, Nico and Wilson, I. D. and Riley, R. J.}, title = {The pharmacokinetics and metabolism of diclofenac in chimeric humanized and murinized FRG mice}, series = {Archives of Toxicology}, volume = {92}, journal = {Archives of Toxicology}, number = {6}, publisher = {Springer}, issn = {1432-0738}, doi = {10.1007/s00204-018-2212-1}, pages = {1953 -- 1967}, year = {2018}, abstract = {The pharmacokinetics of diclofenac were investigated following single oral doses of 10 mg/kg to chimeric liver humanized and murinized FRG and C57BL/6 mice. In addition, the metabolism and excretion were investigated in chimeric liver humanized and murinized FRG mice. Diclofenac reached maximum blood concentrations of 2.43 ± 0.9 µg/mL (n = 3) at 0.25 h post-dose with an AUCinf of 3.67 µg h/mL and an effective half-life of 0.86 h (n = 2). In the murinized animals, maximum blood concentrations were determined as 3.86 ± 2.31 µg/mL at 0.25 h post-dose with an AUCinf of 4.94 ± 2.93 µg h/mL and a half-life of 0.52 ± 0.03 h (n = 3). In C57BL/6J mice, mean peak blood concentrations of 2.31 ± 0.53 µg/mL were seen 0.25 h post-dose with a mean AUCinf of 2.10 ± 0.49 µg h/mL and a half-life of 0.51 ± 0.49 h (n = 3). Analysis of blood indicated only trace quantities of drug-related material in chimeric humanized and murinized FRG mice. Metabolic profiling of urine, bile and faecal extracts revealed a complex pattern of metabolites for both humanized and murinized animals with, in addition to unchanged parent drug, a variety of hydroxylated and conjugated metabolites detected. The profiles in humanized mice were different to those of both murinized and wild-type animals, e.g., a higher proportion of the dose was detected in the form of acyl glucuronide metabolites and much reduced amounts as taurine conjugates. Comparison of the metabolic profiles obtained from the present study with previously published data from C57BL/6J mice and humans revealed a greater, though not complete, match between chimeric humanized mice and humans, such that the liver humanized FRG model may represent a model for assessing the biotransformation of such compounds in humans.}, language = {en} } @article{WilmingBegemannKuhneetal.2013, author = {Wilming, Anja and Begemann, Jens and Kuhne, Stefan and Regestein, Lars and Bongaerts, Johannes and Evers, Stefan and Maurer, Karl-Heinz and B{\"u}chs, Jochen}, title = {Metabolic studies of γ-polyglutamic acid production in Bacillus licheniformis by small-scale continuous cultivations}, series = {Biochemical engineering journal}, volume = {Vol. 73}, journal = {Biochemical engineering journal}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1873-295X (E-Journal); 1369-703X (Print)}, pages = {29 -- 37}, year = {2013}, language = {en} } @incollection{Wilke2016, author = {Wilke, Thomas}, title = {Planning Process of the Di Castellamonte's Chapel of the Holy Shroud}, series = {Carlo e Amedeo di Castellamonte : 1571-1683, ingegneri e architetti per i duchi di Savoia}, booktitle = {Carlo e Amedeo di Castellamonte : 1571-1683, ingegneri e architetti per i duchi di Savoia}, editor = {Merlotti, Andrea}, publisher = {Campisano editore}, address = {Rom}, isbn = {978-88-98229-57-4}, pages = {141 -- 152}, year = {2016}, language = {en} } @article{Wilke2017, author = {Wilke, Thomas}, title = {Newly found plans for the chapel of the Holy Shroud}, series = {Studi Piemontesi}, volume = {XLVI}, journal = {Studi Piemontesi}, number = {1}, issn = {0392-7261}, pages = {75 -- 85}, year = {2017}, language = {en} } @article{WildSchrezenmeierCzupallaetal.2020, author = {Wild, Dominik and Schrezenmeier, Johannes and Czupalla, Markus and F{\"o}rstner, Markus}, title = {Thermal Characterization of additive manufactured Integral Structures for Phase Change Applications}, series = {2020 International Conference on Environmental Systems}, journal = {2020 International Conference on Environmental Systems}, publisher = {Texas Tech University}, year = {2020}, abstract = {"Infused Thermal Solutions" (ITS) introduces a method for passive thermal control to stabilize structural components thermally without active heating and cooling systems, by using phase change material (PCM) in combination with lattice - both embedded into an additive manufactured integral structure. The technology is currently under development. This paper presents the results of the thermal property measurements performed on additive manufactured ITS breadboards. Within the breadboard campaigns key characteristics of the additive manufactured specimens were derived: Mechanical parameters: specimen impermeability, minimum wall thickness, lattice structure, subsequent heat treatment. Thermal properties: thermo-optical surface properties of the additive manufactured raw material, thermal conductivity and specific heat capacity measurements. As a conclusion the paper introduces an overview of potential ITS hardware applications, expected to increase the thermal performance.}, language = {en} } @article{WiesenTippkoetterMuffleretal.2015, author = {Wiesen, Sebastian and Tippk{\"o}tter, Nils and Muffler, Kai and Suck, Kirstin and Sohling, Ulrich and Ruf, Friedrich and Ulber, Roland}, title = {Adsorption of fatty acids to layered double hydroxides in aqueous systems}, series = {Adsorption}, volume = {21}, journal = {Adsorption}, number = {6-7}, publisher = {Springer}, address = {Berlin}, pages = {459 -- 466}, year = {2015}, abstract = {Due to their anion exchange characteristics, layered double hydroxides (LDHs) are suitable for the detoxification of aqueous, fatty acid containing fermentation substrates. The aim of this study is to examine the adsorption mechanism, using crude glycerol from plant oil esterification as a model system. Changes in the intercalation structure in relation to the amount of fatty acids adsorbed are monitored by X-ray diffraction and infra-red spectroscopy. Additionally, calcination of LDH is investigated in order to increase the binding capacity for fatty acids. Our data propose that, at ambient temperature, fatty acids can be bound to the hydrotalcite by adsorption or in addition by intercalation, depending on fatty acid concentration. The adsorption of fatty acids from crude glycerol shows a BET-like behavior. Above a fatty acid concentration of 3.5 g L-1, intercalation of fatty acids can be shown by the appearance of an increased interlayer spacing. This observation suggests a two phase adsorption process. Calcination of LDHs allows increasing the binding capacity for fatty acids by more than six times, mainly by reduction of structural CO32-.}, language = {en} } @inproceedings{WiesenEngemannLimpertetal.2018, author = {Wiesen, Patrick and Engemann, Heiko and Limpert, Nicolas and Kallweit, Stephan}, title = {Learning by Doing - Mobile Robotics in the FH Aachen ROS Summer School}, series = {European Robotics Forum 2018, TRROS18 Workshop}, booktitle = {European Robotics Forum 2018, TRROS18 Workshop}, pages = {47 -- 58}, year = {2018}, language = {en} } @inproceedings{WiegnerVolkerMainzetal.2022, author = {Wiegner, Jonas and Volker, Hanno and Mainz, Fabian and Backes, Andreas and L{\"o}ken, Michael and H{\"u}ning, Felix}, title = {Wiegand-effect-powered wireless IoT sensor node}, series = {Sensoren und Messsysteme 2022}, booktitle = {Sensoren und Messsysteme 2022}, publisher = {VDE Verlag GmbH}, address = {Berlin}, isbn = {978-3-8007-5835-7}, pages = {255 -- 260}, year = {2022}, abstract = {In this article we describe an Internet-of-Things sensing device with a wireless interface which is powered by the oftenoverlooked harvesting method of the Wiegand effect. The sensor can determine position, temperature or other resistively measurable quantities and can transmit the data via an ultra-low power ultra-wideband (UWB) data transmitter. With this approach we can energy-self-sufficiently acquire, process, and wirelessly transmit data in a pulsed operation. A proof-of-concept system was built up to prove the feasibility of the approach. The energy consumption of the system is analyzed and traced back in detail to the individual components, compared to the generated energy and processed to identify further optimization options. Based on the proof-of-concept, an application demonstrator was developed. Finally, we point out possible use cases.}, language = {en} } @article{WiegnerVolkerMainzetal.2023, author = {Wiegner, Jonas and Volker, Hanno and Mainz, Fabian and Backes, Andreas and Loeken, Michael and H{\"u}ning, Felix}, title = {Energy analysis of a wireless sensor node powered by a Wiegand sensor}, series = {Journal of Sensors and Sensor Systems (JSSS)}, volume = {12}, journal = {Journal of Sensors and Sensor Systems (JSSS)}, number = {1}, publisher = {Copernicus Publ.}, address = {G{\"o}ttingen}, issn = {2194-878X}, doi = {10.5194/jsss-12-85-2023}, pages = {85 -- 92}, year = {2023}, abstract = {This article describes an Internet of things (IoT) sensing device with a wireless interface which is powered by the energy-harvesting method of the Wiegand effect. The Wiegand effect, in contrast to continuous sources like photovoltaic or thermal harvesters, provides small amounts of energy discontinuously in pulsed mode. To enable an energy-self-sufficient operation of the sensing device with this pulsed energy source, the output energy of the Wiegand generator is maximized. This energy is used to power up the system and to acquire and process data like position, temperature or other resistively measurable quantities as well as transmit these data via an ultra-low-power ultra-wideband (UWB) data transmitter. A proof-of-concept system was built to prove the feasibility of the approach. The energy consumption of the system during start-up was analysed, traced back in detail to the individual components, compared to the generated energy and processed to identify further optimization options. Based on the proof of concept, an application prototype was developed.}, language = {en} } @misc{WiegnerVolkerMainzetal.2022, author = {Wiegner, J. and Volker, H. and Mainz, F. and Backes, A. and L{\"o}ken, M. and H{\"u}ning, Felix}, title = {Wiegand-Effect-Powered Wireless IT Sensor Node}, year = {2022}, abstract = {With the growing interest in small distributed sensors for the "Internet of Things", more attention is being paid to energy harvesting techologies. Reducing or eliminating the need for external power sources or batteries make devices more self-sufficient, more reliable, and reduces maintenance requirements. The Wiegand effect is a proven technology for harvesting small amounts of electrical power from mechanical motion.}, language = {en} } @article{WiegandVoigtAlbrechtetal.2013, author = {Wiegand, Sandra and Voigt, Birgit and Albrecht, Dirk and Bongaerts, Johannes and Evers, Stefan and Hecker, Michael and Daniel, Rolf and Liesegang, Heiko}, title = {Fermentation stage-dependent adaptations of Bacillus licheniformis during enzyme production}, series = {Microbial Cell Factories}, volume = {12}, journal = {Microbial Cell Factories}, publisher = {Biomed Central}, address = {London}, issn = {1475-2859}, doi = {10.1186/1475-2859-12-120}, pages = {120}, year = {2013}, language = {en} } @article{WiegandDietrichHerteletal.2013, author = {Wiegand, Sandra and Dietrich, Sascha and Hertel, Robert and Bongaerts, Johannes and Evers, Stefan and Volland, Sonja and Daniel, Rolf and Liesegang, Heiko}, title = {RNA-Seq of Bacillus licheniformis: active regulatory RNA features expressed within a productive fermentation}, series = {BMC genomics}, volume = {Vol. 14}, journal = {BMC genomics}, publisher = {BioMed Central}, address = {London}, issn = {1471-2164}, pages = {667}, year = {2013}, language = {en} } @article{WhiteheadOehlschlaegerAlmajhdietal.2014, author = {Whitehead, Mark and {\"O}hlschl{\"a}ger, Peter and Almajhdi, Fahad N. and Alloza, Leonor and Marz{\´a}bal, Pablo and Meyers, Ann E. and Hitzeroth, Inga I. and Rybicki, Edward P.}, title = {Human papillomavirus (HPV) type 16 E7 protein bodies cause tumour regression in mice}, series = {BMC cancer}, journal = {BMC cancer}, number = {14:367}, publisher = {BioMed Central}, address = {London}, issn = {1471-2407}, doi = {10.1186/1471-2407-14-367}, pages = {1 -- 15}, year = {2014}, language = {en} } @inproceedings{Wessling2007, author = {Weßling, Matthias}, title = {Leadership Perspectives: Research Findings, Theories, Practical Experiences}, year = {2007}, abstract = {Leadership Perspectives: Research Findings, Theories, Practical Experiences: Results of Leadership Research and exemplarily application cases show the perspectives and consequences for leadership practice and the following requirements for executives in future.}, subject = {Leadership}, language = {en} } @inproceedings{Wessling2007, author = {Weßling, Matthias}, title = {Motivation and Leadership - The Reiss-Profile of the 16 Basic Desires: Research results and managerial applications}, year = {2007}, abstract = {Recent Results of the scientific Reiss-Profile (16 basic desires) due to the concept of Prof. Dr. Steven Reiss (State University Ohio, U.S.A.), supplemented by the comparative analysis of empirical motivational profiles of european executives of various companies.}, subject = {Motivation}, language = {en} } @inproceedings{Wessling2007, author = {Weßling, Matthias}, title = {Provocative Communication in Coaching and Leadership: scientific research and managerial applications of the Provocative Communication Style}, year = {2007}, abstract = {Concept, scientific research and managerial applications of Provocative Coaching, according to the „Provocative Therapy" of Prof. Dr. Frank Farrelly (University of Wisconsin, U.S.A) in terms of an application of the Provocative Communication Style in specific situations of practical leadership, especially in the role of a coach for their subordinates.}, subject = {Kommunikation}, language = {en} }