@article{ZhantlessovaSavitskayaKistaubayevaetal.2022, author = {Zhantlessova, Sirina and Savitskaya, Irina and Kistaubayeva, Aida and Ignatova, Ludmila and Talipova, Aizhan and Pogrebnjak, Alexander and Digel, Ilya}, title = {Advanced "Green" prebiotic composite of bacterial cellulose/pullulan based on synthetic biology-powered microbial coculture strategy}, series = {Polymers}, volume = {14}, journal = {Polymers}, number = {15}, publisher = {MDPI}, address = {Basel}, issn = {2073-4360}, doi = {10.3390/polym14153224}, pages = {Artikel 3224}, year = {2022}, abstract = {Bacterial cellulose (BC) is a biopolymer produced by different microorganisms, but in biotechnological practice, Komagataeibacter xylinus is used. The micro- and nanofibrillar structure of BC, which forms many different-sized pores, creates prerequisites for the introduction of other polymers into it, including those synthesized by other microorganisms. The study aims to develop a cocultivation system of BC and prebiotic producers to obtain BC-based composite material with prebiotic activity. In this study, pullulan (PUL) was found to stimulate the growth of the probiotic strain Lactobacillus rhamnosus GG better than the other microbial polysaccharides gellan and xanthan. BC/PUL biocomposite with prebiotic properties was obtained by cocultivation of Komagataeibacter xylinus and Aureobasidium pullulans, BC and PUL producers respectively, on molasses medium. The inclusion of PUL in BC is proved gravimetrically by scanning electron microscopy and by Fourier transformed infrared spectroscopy. Cocultivation demonstrated a composite effect on the aggregation and binding of BC fibers, which led to a significant improvement in mechanical properties. The developed approach for "grafting" of prebiotic activity on BC allows preparation of environmentally friendly composites of better quality.}, language = {en} } @article{ZhangHeimbachScheeretal.2016, author = {Zhang, Jin and Heimbach, Tycho and Scheer, Nico and Barve, Avantika and Li, Wenkui and Lin, Wen and He, Handan}, title = {Clinical Exposure Boost Predictions by Integrating Cytochrome P450 3A4-Humanized Mouse Studies With PBPK Modeling}, series = {Journal of Pharmaceutical Sciences}, volume = {Volume 105}, journal = {Journal of Pharmaceutical Sciences}, number = {Issue 4}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0022-3549}, doi = {doi.org/10.1016/j.xphs.2016.01.021}, pages = {1398 -- 1404}, year = {2016}, abstract = {NVS123 is a poorly water-soluble protease 56 inhibitor in clinical development. Data from in vitro hepatocyte studies suggested that NVS123 is mainly metabolized by CYP3A4. As a consequence of limited solubility, NVS123 therapeutic plasma exposures could not be achieved even with high doses and optimized formulations. One approach to overcome NVS123 developability issues was to increase plasma exposure by coadministrating it with an inhibitor of CYP3A4 such as ritonavir. A clinical boost effect was predicted by using physiologically based pharmacokinetic (PBPK) modeling. However, initial boost predictions lacked sufficient confidence because a key parameter, fraction of drug metabolized by CYP3A4 (ƒₘCYP3A4), could not be estimated with accuracy on account of disconnects between in vitro and in vivo preclinical data. To accurately estimate ƒₘCYP3A4 in human, an in vivo boost effect study was conducted using CYP3A4-humanized mouse model which showed a 33- to 56-fold exposure boost effect. Using a top-down approach, human ƒₘCYP3A4 for NVS123 was estimated to be very high and included in the human PBPK modeling to support subsequent clinical study design. The combined use of the in vivo boost study in CYP3A4-humanized mouse model mice along with PBPK modeling accurately predicted the clinical outcome and identified a significant NVS123 exposure boost (∼42-fold increase) with ritonavir.}, language = {en} } @article{ZhangValeroBungetal.2018, author = {Zhang, G. and Valero, Daniel and Bung, Daniel Bernhard and Chanson, H.}, title = {On the estimation of free-surface turbulence using ultrasonic sensors}, series = {Flow Measurement and Instrumentation}, volume = {60}, journal = {Flow Measurement and Instrumentation}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0955-5986}, doi = {10.1016/j.flowmeasinst.2018.02.009}, pages = {171 -- 184}, year = {2018}, abstract = {Accurate determination of free-surface dynamics has attracted much research attention during the past decade and has important applications in many environmental and water related areas. In this study, the free-surface dynamics in several turbulent flows commonly found in nature were investigated using a synchronised setup consisting of an ultrasonic sensor and a high-speed video camera. Basic sensor capabilities were examined in dry conditions to allow for a better characterisation of the present sensor model. The ultrasonic sensor was found to adequately reproduce free-surface dynamics up to the second order, especially in two-dimensional scenarios with the most energetic modes in the low frequency range. The sensor frequency response was satisfactory in the sub-20 Hz band, and its signal quality may be further improved by low-pass filtering prior to digitisation. The application of the USS to characterise entrapped air in high-velocity flows is also discussed.}, language = {en} } @article{ZerlinKasischkeDigeletal.2007, author = {Zerlin, Kay and Kasischke, Nicole and Digel, Ilya and Maggakis-Kelemen, Christina and Temiz Artmann, Ayseg{\"u}l and Porst, Dariusz and Kayser, Peter and Linder, Peter and Artmann, Gerhard}, title = {Structural transition temperature of hemoglobins correlates with species' body temperature}, series = {European Biophysics Journal. 37 (2007), H. 1}, journal = {European Biophysics Journal. 37 (2007), H. 1}, isbn = {1432-1017}, pages = {1 -- 10}, year = {2007}, language = {en} } @article{ZerlinDigelStadleretal.2007, author = {Zerlin, Kay and Digel, Ilya and Stadler, Andreas M. and B{\"u}ldt, Georg and Zaccai, Guiseppe and Artmann, Gerhard}, title = {Dynamics and interactions of hemoglobin in human red blood cells and concentrated hemoglobin solutions}, series = {Regenerative medicine. 2 (2007), H. 5}, journal = {Regenerative medicine. 2 (2007), H. 5}, isbn = {1746-0751}, pages = {573 -- 573}, year = {2007}, language = {en} } @article{ZatkoDubeckyBohaceketal.2004, author = {Zatko, B. and Dubeck{\´y}, F. and Bohacek, P. and Gombia, E. and Frigeri, P. and Mosca, R. and Franchi, S. and Huarn, J. and Nescas, V. and Sekacova, M. and F{\"o}rster, Arnold and Kordos, P.}, title = {On the spectrometric performance limit of radiation detectors based on semi-insulating GaAs}, series = {Nuclear instruments and methods in physics research, Section A. 531 (2004), H. 1-2}, journal = {Nuclear instruments and methods in physics research, Section A. 531 (2004), H. 1-2}, isbn = {0168-9002}, pages = {111 -- 120}, year = {2004}, language = {en} } @article{ZastrowRieder1980, author = {Zastrow, Udo and Rieder, G.}, title = {Bracketing eigenvalues of an oscillating elastic body by integral equations}, series = {Bracketing of eigenfrequencies of continous structures : Euromech Colloquium, no. 112, M{\´a}traf{\"u}red (Hungary), 21 - 23 February, 1979 / ed. by {\`A}. Bosznay}, journal = {Bracketing of eigenfrequencies of continous structures : Euromech Colloquium, no. 112, M{\´a}traf{\"u}red (Hungary), 21 - 23 February, 1979 / ed. by {\`A}. Bosznay}, publisher = {Akad. Kiad{\´o}}, address = {Budapest}, isbn = {963-05-2625-5}, pages = {421 -- 434}, year = {1980}, language = {en} } @article{ZastrowPanagiotopoulos1979, author = {Zastrow, Udo and Panagiotopoulos, P. D.}, title = {An integral "Equation" approach to the unilateral contact problem}, series = {ZAMM - Zeitschrift f{\"u}r angewandte Mathematik und Mechanik. 59 (1979), H. 8}, journal = {ZAMM - Zeitschrift f{\"u}r angewandte Mathematik und Mechanik. 59 (1979), H. 8}, isbn = {1521-4001}, pages = {392 -- 393}, year = {1979}, language = {en} } @article{ZastrowHackl1988, author = {Zastrow, Udo and Hackl, Klaus}, title = {On the existence, uniqueness and completeness of displacements and stress functions in linear elasticity / Hackl, Klaus ; Zastrow, Udo}, series = {Journal of Elasticity. 19 (1988), H. 1}, journal = {Journal of Elasticity. 19 (1988), H. 1}, isbn = {1573-2681}, pages = {3 -- 23}, year = {1988}, language = {en} } @article{Zastrow1985, author = {Zastrow, Udo}, title = {On the complete system of fundamental solutions for anisotropic slices and slabs: A comparison by use of the slab analogy}, series = {Journal of Elasticity. 15 (1985), H. 3}, journal = {Journal of Elasticity. 15 (1985), H. 3}, isbn = {1573-2681}, pages = {293 -- 318}, year = {1985}, language = {en} } @article{Zastrow1985, author = {Zastrow, Udo}, title = {Basic geometrical singularities in plane-elasticity and plate-bending problems}, series = {International Journal of Solids and Structures. 21 (1985), H. 10}, journal = {International Journal of Solids and Structures. 21 (1985), H. 10}, isbn = {0020-7683}, pages = {1047 -- 1067}, year = {1985}, language = {en} } @article{Zastrow1985, author = {Zastrow, Udo}, title = {Numerical plane stress analysis by integral equations based on the singularity method}, series = {SM archives . 10 (1985)}, journal = {SM archives . 10 (1985)}, isbn = {0376-7426}, pages = {113 -- 128}, year = {1985}, language = {en} } @article{Zastrow1982, author = {Zastrow, Udo}, title = {Solution of plane anisotropic elastostatical boundary value problems by singular integral equations}, series = {Acta Mechanica. 44 (1982), H. 1-2}, journal = {Acta Mechanica. 44 (1982), H. 1-2}, isbn = {1619-6937}, pages = {59 -- 71}, year = {1982}, language = {en} } @article{Zastrow1985, author = {Zastrow, Udo}, title = {On the formulation of the fundamental solutions for orthotropic plane elasticity}, series = {Acta Mechanica. 57 (1985), H. 3-4}, journal = {Acta Mechanica. 57 (1985), H. 3-4}, isbn = {1619-6937}, pages = {113 -- 122}, year = {1985}, language = {en} } @article{ZangeSchopenAlbrachtetal.2017, author = {Zange, Jochen and Schopen, Kathrin and Albracht, Kirsten and Gerlach, Darius A. and Frings-Meuthen, Petra and Maffiuletti, Nicola A. and Bloch, Wilhelm and Rittweger, J{\"o}rn}, title = {Using the Hephaistos orthotic device to study countermeasure effectiveness of neuromuscular electrical stimulation and dietary lupin protein supplementation, a randomised controlled trial}, series = {Plos one}, volume = {12}, journal = {Plos one}, number = {2}, doi = {10.1371/journal.pone.0171562}, year = {2017}, language = {en} } @inproceedings{ZangHessRingbecketal.2002, author = {Zang, Zhigang and Hess, Holger and Ringbeck, Thorsten and Schwarte, Rudolf}, title = {Phase-lock techniques using new correlation receivers for TOF-laser ranging}, series = {Laser radar technology and applications VII : 3 - 4 April 2002, Orlando, USA. - (SPIE proceedings series ; 4723)}, booktitle = {Laser radar technology and applications VII : 3 - 4 April 2002, Orlando, USA. - (SPIE proceedings series ; 4723)}, editor = {Kamerman, Gary W.}, publisher = {SPIE, International Society for Optical Engineering}, address = {Bellingham, Wash.}, isbn = {0-8194-4473-1}, issn = {0038-7355}, doi = {10.1117/12.476402}, pages = {112 -- 120}, year = {2002}, language = {en} } @inproceedings{ZahraPhaniSrujanChicoCaminosetal.2022, author = {Zahra, Mahdi and Phani Srujan, Merige and Chico Caminos, Ricardo Alexander and Schmitz, Pascal and Herrmann, Ulf and Teixeira Boura, Cristiano Jos{\´e} and Schmitz, Mark and Gielen, Hans and Gedle, Yibekal and Dersch, J{\"u}rgen}, title = {Modeling the thermal behavior of solar salt in electrical resistance heaters for the application in PV-CSP hybrid power plants}, series = {SOLARPACES 2020}, booktitle = {SOLARPACES 2020}, number = {2445 / 1}, publisher = {AIP conference proceedings / American Institute of Physics}, address = {Melville, NY}, isbn = {978-0-7354-4195-8}, issn = {1551-7616 (online)}, doi = {10.1063/5.0086268}, pages = {9 Seiten}, year = {2022}, abstract = {Concentrated Solar Power (CSP) systems are able to store energy cost-effectively in their integrated thermal energy storage (TES). By intelligently combining Photovoltaics (PV) systems with CSP, a further cost reduction of solar power plants is expected, as well as an increase in dispatchability and flexibility of power generation. PV-powered Resistance Heaters (RH) can be deployed to raise the temperature of the molten salt hot storage from 385 °C up to 565 °C in a Parabolic Trough Collector (PTC) plant. To avoid freezing and decomposition of molten salt, the temperature distribution in the electrical resistance heater is investigated in the present study. For this purpose, a RH has been modeled and CFD simulations have been performed. The simulation results show that the hottest regions occur on the electric rod surface behind the last baffle. A technical optimization was performed by adjusting three parameters: Shell-baffle clearance, electric rod-baffle clearance and number of baffles. After the technical optimization was carried out, the temperature difference between the maximum temperature and the average outlet temperature of the salt is within the acceptable limits, thus critical salt decomposition has been avoided. Additionally, the CFD simulations results were analyzed and compared with results obtained with a one-dimensional model in Modelica.}, language = {en} } @book{YoshinobuSchoening2020, author = {Yoshinobu, Tatsuo and Sch{\"o}ning, Michael Josef}, title = {Light-addressing and chemical imaging technologies for electrochemical sensing}, editor = {Yoshinobu, Tatsuo and Sch{\"o}ning, Michael Josef}, publisher = {MDPI}, address = {Basel}, isbn = {978-3-03943-029-1}, doi = {10.3390/books978-3-03943-029-1}, pages = {122 Pages}, year = {2020}, language = {en} } @article{YoshinobuSchoening2021, author = {Yoshinobu, Tatsuo and Sch{\"o}ning, Michael Josef}, title = {Light-addressable potentiometric sensors (LAPS) for cell monitoring and biosensing}, series = {Current Opinion in Electrochemistry}, journal = {Current Opinion in Electrochemistry}, number = {In Press, Journal Pre-proof}, publisher = {Elsevier}, address = {Amsterdam}, issn = {2451-9103}, doi = {10.1016/j.coelec.2021.100727}, year = {2021}, language = {en} } @article{YoshinobuMoritzFingeretal.2006, author = {Yoshinobu, Tatsuo and Moritz, Werner and Finger, Friedhelm and Sch{\"o}ning, Michael Josef}, title = {Application of thin-film amorphous silicon to chemical imaging}, series = {Nanostructured materials and hybrid composites for gas sensors and biomedical applications : symposium held April 18-20, 2006, San Francisco , California, U.S.A.}, journal = {Nanostructured materials and hybrid composites for gas sensors and biomedical applications : symposium held April 18-20, 2006, San Francisco , California, U.S.A.}, number = {Paper 0910-A-20-01}, editor = {Comini, Elisabetta}, isbn = {9781558998711}, pages = {1 -- 10}, year = {2006}, language = {en} }