@book{Laack2021, author = {Laack, Walter van}, title = {Gr{\"o}ßer als das ganze Universum}, publisher = {van Laack GmbH}, address = {Aachen}, isbn = {978-3-936624-38-0}, pages = {120 Seiten}, year = {2021}, language = {de} } @article{KoehlerRoepkeWolf2021, author = {K{\"o}hler, Klemens and R{\"o}pke, Ren{\´e} and Wolf, Martin}, title = {Through a mirror darkly - On the obscurity of teaching goals in game-based learning in IT security}, series = {ISAGA 2019: Simulation Gaming Through Times and Disciplines}, journal = {ISAGA 2019: Simulation Gaming Through Times and Disciplines}, publisher = {Springer}, address = {Cham}, doi = {10.1007/978-3-030-72132-9_6}, pages = {61 -- 73}, year = {2021}, abstract = {Teachers and instructors use very specific language communicating teaching goals. The most widely used frameworks of common reference are the Bloom's Taxonomy and the Revised Bloom's Taxonomy. The latter provides distinction of 209 different teaching goals which are connected to methods. In Competence Developing Games (CDGs - serious games to convey knowledge) and in IT security education, a two- or three level typology exists, reducing possible learning outcomes to awareness, training, and education. This study explores whether this much simpler framework succeeds in achieving the same range of learning outcomes. Method wise a keyword analysis was conducted. The results were threefold: 1. The words used to describe teaching goals in CDGs on IT security education do not reflect the whole range of learning outcomes. 2. The word choice is nevertheless different from common language, indicating an intentional use of language. 3. IT security CDGs use different sets of terms to describe learning outcomes, depending on whether they are awareness, training, or education games. The interpretation of the findings is that the reduction to just three types of CDGs reduces the capacity to communicate and think about learning outcomes and consequently reduces the outcomes that are intentionally achieved.}, language = {en} } @book{KurzSchwer2021, author = {Kurz, Melanie and Schwer, Thilo}, title = {Designentscheidungen : {\"u}ber Begr{\"u}ndungen im Entwurfsprozess / herausgegeben von Melanie Kurz und Thilo Schwer}, series = {Schriften / Gesellschaft f{\"u}r Designgeschichte}, journal = {Schriften / Gesellschaft f{\"u}r Designgeschichte}, publisher = {avedition}, address = {Stuttgart}, isbn = {978-3-89986-353-6}, pages = {143 Seiten : Illustrationen}, year = {2021}, language = {de} } @incollection{Kurz2021, author = {Kurz, Melanie}, title = {Zur Multikausalit{\"a}t von Designentscheidungen - eine Beispielsammlung}, series = {Designentscheidungen: {\"u}ber Begr{\"u}ndungen im Entwurfsprozess}, booktitle = {Designentscheidungen: {\"u}ber Begr{\"u}ndungen im Entwurfsprozess}, publisher = {avedition}, address = {Stuttgart}, isbn = {978-3-89986-353-6}, pages = {22 -- 43}, year = {2021}, language = {de} } @article{KuertenKotliarFuestetal.2021, author = {Kuerten, David and Kotliar, Konstantin and Fuest, Matthias and Walter, Peter and Hollstein, Muriel and Plange, Niklas}, title = {Does hemispheric vascular regulation differ significantly in glaucoma patients with altitudinal visual field asymmetry? A single-center, prospective study}, series = {International Ophthalmology}, volume = {41}, journal = {International Ophthalmology}, number = {41}, editor = {Neri, Piergiorgio}, publisher = {Springer}, address = {Berlin}, isbn = {1573-2630}, doi = {10.1007/s10792-021-01876-0}, pages = {3109 -- 3119}, year = {2021}, abstract = {Purpose Vascular risk factors and ocular perfusion are heatedly discussed in the pathogenesis of glaucoma. The retinal vessel analyzer (RVA, IMEDOS Systems, Germany) allows noninvasive measurement of retinal vessel regulation. Significant differences especially in the veins between healthy subjects and patients suffering from glaucoma were previously reported. In this pilot-study we investigated if localized vascular regulation is altered in glaucoma patients with altitudinal visual field defect asymmetry. Methods 15 eyes of 12 glaucoma patients with advanced altitudinal visual field defect asymmetry were included. The mean defect was calculated for each hemisphere separately (-20.99 ± 10.49 pro- found hemispheric visual field defect vs -7.36 ± 3.97 dB less profound hemisphere). After pupil dilation, RVA measurements of retinal arteries and veins were conducted using the standard protocol. The superior and inferior retinal vessel reactivity were measured consecutively in each eye. Results Significant differences were recorded in venous vessel constriction after flicker light stimulation and overall amplitude of the reaction (p \ 0.04 and p \ 0.02 respectively) in-between the hemispheres spheres. Vessel reaction was higher in the hemisphere corresponding to the more advanced visual field defect. Arterial diameters reacted similarly, failing to reach statistical significance. Conclusion Localized retinal vessel regulation is significantly altered in glaucoma patients with asymmetri altitudinal visual field defects. Veins supplying the hemisphere concordant to a less profound visual field defect show diminished diameter changes. Vascular dysregulation might be particularly important in early glaucoma stages prior to a significant visual field defect.}, language = {en} } @inproceedings{KronigerHorikawaFunkeetal.2021, author = {Kroniger, Daniel and Horikawa, Atsushi and Funke, Harald and Pf{\"a}ffle, Franziska and Kishimoto, Tsuyoshi and Okada, Koichi}, title = {Experimental and numerical investigation on the effect of pressure on micromix hydrogen combustion}, series = {ASME Turbo Expo 2021: Turbomachinery Technical Conference and Exposition // Volume 3A: Combustion, Fuels, and Emissions}, booktitle = {ASME Turbo Expo 2021: Turbomachinery Technical Conference and Exposition // Volume 3A: Combustion, Fuels, and Emissions}, doi = {10.1115/GT2021-58926}, pages = {11 Seiten}, year = {2021}, abstract = {The micromix (MMX) combustion concept is a DLN gas turbine combustion technology designed for high hydrogen content fuels. Multiple non-premixed miniaturized flames based on jet in cross-flow (JICF) are inherently safe against flashback and ensure a stable operation in various operative conditions. The objective of this paper is to investigate the influence of pressure on the micromix flame with focus on the flame initiation point and the NOx emissions. A numerical model based on a steady RANS approach and the Complex Chemistry model with relevant reactions of the GRI 3.0 mechanism is used to predict the reactive flow and NOx emissions at various pressure conditions. Regarding the turbulence-chemical interaction, the Laminar Flame Concept (LFC) and the Eddy Dissipation Concept (EDC) are compared. The numerical results are validated against experimental results that have been acquired at a high pressure test facility for industrial can-type gas turbine combustors with regard to flame initiation and NOx emissions. The numerical approach is adequate to predict the flame initiation point and NOx emission trends. Interestingly, the flame shifts its initiation point during the pressure increase in upstream direction, whereby the flame attachment shifts from anchoring behind a downstream located bluff body towards anchoring directly at the hydrogen jet. The LFC predicts this change and the NOx emissions more accurately than the EDC. The resulting NOx correlation regarding the pressure is similar to a non-premixed type combustion configuration.}, language = {en} } @inproceedings{KronigerHorikawaFunkeetal.2021, author = {Kroniger, Daniel and Horikawa, Atsushi and Funke, Harald and Pf{\"a}ffle, Franziska}, title = {Numerical investigation of micromix hydrogen flames at different combustor pressure levels}, series = {Proceedings of the International Conference on Power Engineering 2021}, booktitle = {Proceedings of the International Conference on Power Engineering 2021}, pages = {4 Seiten}, year = {2021}, abstract = {This study investigates the influence of pressure on the temperature distribution of the micromix (MMX) hydrogen flame and the NOx emissions. A steady computational fluid dynamic (CFD) analysis is performed by simulating a reactive flow with a detailed chemical reaction model. The numerical analysis is validated based on experimental investigations. A quantitative correlation is parametrized based on the numerical results. We find, that the flame initiation point shifts with increasing pressure from anchoring behind a downstream located bluff body towards anchoring upstream at the hydrogen jet. The numerical NOx emissions trend regarding to a variation of pressure is in good agreement with the experimental results. The pressure has an impact on both, the residence time within the maximum temperature region and on the peak temperature itself. In conclusion, the numerical model proved to be adequate for future prototype design exploration studies targeting on improving the operating range.}, language = {en} } @incollection{Kotliar2021, author = {Kotliar, Konstantin}, title = {Ocular rigidity: clinical approach}, series = {Ocular Rigidity, Biomechanics and Hydrodynamics of the Eye}, booktitle = {Ocular Rigidity, Biomechanics and Hydrodynamics of the Eye}, editor = {Pallikaris, I. and Tsilimbaris, M. K. and Dastiridou, A. I.}, publisher = {Springer}, address = {Cham}, isbn = {978-3-030-64422-2}, doi = {10.1007/978-3-030-64422-2_2}, pages = {15 -- 43}, year = {2021}, abstract = {The term ocular rigidity is widely used in clinical ophthalmology. Generally it is assumed as a resistance of the whole eyeball to mechanical deformation and relates to biomechanical properties of the eye and its tissues. Basic principles and formulas for clinical tonometry, tonography and pulsatile ocular blood flow measurements are based on the concept of ocular rigidity. There is evidence for altered ocular rigidity in aging, in several eye diseases and after eye surgery. Unfortunately, there is no consensual view on ocular rigidity: it used to make a quite different sense for different people but still the same name. Foremost there is no clear consent between biomechanical engineers and ophthalmologists on the concept. Moreover ocular rigidity is occasionally characterized using various parameters with their different physical dimensions. In contrast to engineering approach, clinical approach to ocular rigidity claims to characterize the total mechanical response of the eyeball to its deformation without any detailed considerations on eye morphology or material properties of its tissues. Further to the previous chapter this section aims to describe clinical approach to ocular rigidity from the perspective of an engineer in an attempt to straighten out this concept, to show its advantages, disadvantages and various applications.}, language = {en} } @inproceedings{KohlSchmidtsKloeseretal.2021, author = {Kohl, Philipp and Schmidts, Oliver and Kl{\"o}ser, Lars and Werth, Henri and Kraft, Bodo and Z{\"u}ndorf, Albert}, title = {STAMP 4 NLP - an agile framework for rapid quality-driven NLP applications development}, series = {Quality of Information and Communications Technology. QUATIC 2021}, booktitle = {Quality of Information and Communications Technology. QUATIC 2021}, publisher = {Springer}, address = {Cham}, isbn = {978-3-030-85346-4}, doi = {10.1007/978-3-030-85347-1_12}, pages = {156 -- 166}, year = {2021}, abstract = {The progress in natural language processing (NLP) research over the last years, offers novel business opportunities for companies, as automated user interaction or improved data analysis. Building sophisticated NLP applications requires dealing with modern machine learning (ML) technologies, which impedes enterprises from establishing successful NLP projects. Our experience in applied NLP research projects shows that the continuous integration of research prototypes in production-like environments with quality assurance builds trust in the software and shows convenience and usefulness regarding the business goal. We introduce STAMP 4 NLP as an iterative and incremental process model for developing NLP applications. With STAMP 4 NLP, we merge software engineering principles with best practices from data science. Instantiating our process model allows efficiently creating prototypes by utilizing templates, conventions, and implementations, enabling developers and data scientists to focus on the business goals. Due to our iterative-incremental approach, businesses can deploy an enhanced version of the prototype to their software environment after every iteration, maximizing potential business value and trust early and avoiding the cost of successful yet never deployed experiments.}, language = {en} } @masterthesis{Koc2021, type = {Bachelor Thesis}, author = {Koc, {\"O}zge Fethiye}, title = {OFEKO: Lehrmaterial f{\"u}r sehbehinderte Kinder}, publisher = {FH Aachen}, address = {Aachen}, school = {Fachhochschule Aachen}, pages = {117 Seiten}, year = {2021}, abstract = {In einer Mischklasse, bestehend aus sehenden und nicht-sehenden Kindern, welche nicht schriftlich oder spielerisch miteinander kommunizieren k{\"o}nnen, gehen einige soziale Aspekte und Lern{\"u}bungen verloren. Partnerarbeiten und das gegenseitige Kontrollieren der Richtigkeit, beispielsweise bei der Anwendung von Satzzeichen, sind M{\"o}glichkeiten, welche die Kinder ohne ein gemeinsames Material nicht wahrnehmen k{\"o}nnen. Diese Arbeit erm{\"o}glicht ein gemeinsames Arbeiten aller Kinder durch dasselbe Material. Hierf{\"u}r dienen dreidimensionale Objekte, welche im STL-Dateiformat zur Verf{\"u}gung stehen. Es eignet sich f{\"u}r schriftliche und geografische Arbeiten. Des Weiteren ist ein Memory-Spiel enthalten, welches ebenso von sehenden und nicht-sehenden Kinder gespielt werden kann. Diese STLs k{\"o}nnen weltweit verschickt werden, sodass diese beliebig mit einem 3D-Drucker gedruckt werden k{\"o}nnen.}, language = {de} } @masterthesis{Kober2021, type = {Bachelor Thesis}, author = {Kober, Sophie}, title = {DO or DIE: Leistungssport}, publisher = {FH Aachen}, address = {Aachen}, school = {Fachhochschule Aachen}, pages = {81 Seiten}, year = {2021}, abstract = {Es ist dieser eine Moment, der {\"u}ber Versagen oder Erfolg entscheidet. Dieser Augenblick, der so unfassbar wichtig ist und dennoch nicht mal eine Sekunde dauert. Als Leistungssportler bereitet man sich immer und immer wieder auf diesen einen Moment vor. Wie unterscheidet sich dieser Moment in verschiedenen Sportarten? Gibt es ihn {\"u}berhaupt in jeder Sportart? Das Projekt „Do or Die" fokussiert sich auf entscheidende und wichtige Situationen in unterschiedlichen Sportarten und zeigt dabei die Facetten und Vielseitigkeit des Leistungssports auf. In einem besonderen Konzept wird der Fokus auf genau diese Momente gelegt und greift den Aspekt des Scheiterns und Erfolgs auf. Es wird untersucht, wie sichtbar diese Augenblicke nach außen hin sind oder inwiefern entscheidende Momente auch nur im Kopf stattfinden und durch Emotionen zu erkennen sind.}, language = {de} } @inproceedings{KloeserKohlKraftetal.2021, author = {Kl{\"o}ser, Lars and Kohl, Philipp and Kraft, Bodo and Z{\"u}ndorf, Albert}, title = {Multi-attribute relation extraction (MARE): simplifying the application of relation extraction}, series = {Proceedings of the 2nd International Conference on Deep Learning Theory and Applications - DeLTA}, booktitle = {Proceedings of the 2nd International Conference on Deep Learning Theory and Applications - DeLTA}, isbn = {978-989-758-526-5}, doi = {10.5220/0010559201480156}, pages = {148 -- 156}, year = {2021}, abstract = {Natural language understanding's relation extraction makes innovative and encouraging novel business concepts possible and facilitates new digitilized decision-making processes. Current approaches allow the extraction of relations with a fixed number of entities as attributes. Extracting relations with an arbitrary amount of attributes requires complex systems and costly relation-trigger annotations to assist these systems. We introduce multi-attribute relation extraction (MARE) as an assumption-less problem formulation with two approaches, facilitating an explicit mapping from business use cases to the data annotations. Avoiding elaborated annotation constraints simplifies the application of relation extraction approaches. The evaluation compares our models to current state-of-the-art event extraction and binary relation extraction methods. Our approaches show improvement compared to these on the extraction of general multi-attribute relations.}, language = {en} } @masterthesis{Kiutsukis2021, type = {Bachelor Thesis}, author = {Kiutsukis, Maria}, title = {KOMU: Entwicklung eines modularen Regalsystems}, publisher = {FH Aachen}, address = {Aachen}, pages = {213 Seiten}, year = {2021}, abstract = {KOMU entstand durch Analysieren der Ver{\"a}nderungen, die mit der Urbanisierung einhergehen - schnell schwindender Wohnraum, h{\"a}ufiges Umziehen und verschmolzene Raumnutzung. KOMU ist ein modulares Regalsystem, das erm{\"o}glicht, problemlos aus denselben Bestandteilen immer wieder verschiedene Wohn- und Raumsituationen zu schaffen. Das System ist komplett werkzeugfrei durch simples Ineinanderstecken aufzubauen. Weitere Add-Ons k{\"o}nnen {\"u}ber das gleiche Stecksystem in das Regal integriert werden, damit es perfekt an die Bed{\"u}rfnisse des Kunden anpasst werden kann. Durch klare Linien und eine cleane Designsprache f{\"u}gt sich KOMU nahtlos in seine Umgebung ein und hilft, eine f{\"u}r den Kunden ideale Umgebung zu schaffen. Ein Regal, das mitw{\"a}chst - vielf{\"a}ltig und individuell.}, language = {de} } @masterthesis{Khalaimova2021, type = {Bachelor Thesis}, author = {Khalaimova, Karina}, title = {Neuerfindung der Ligaturen}, publisher = {FH Aachen}, address = {Aachen}, school = {Fachhochschule Aachen}, pages = {43 Seiten}, year = {2021}, abstract = {Gegenstand des Projekts ist, Ligaturen als erweiterte Mittel der Informations{\"u}bertragung einzusetzen. Ligaturen als zus{\"a}tzliches Instrument sollen die visuelle Komponente des Textes unterst{\"u}tzen, ihm die gewisse Frische einhauchen und ihn hiermit insgesamt sichtbarer, origineller und moderner machen. Der Einsatzbereich erstreckt sich hierbei in die verschiedensten Bereiche hin {\"u}ber Design und Werbung, als auch im Handel oder in sozialen Bereichen. Hierbei kann eine große Anzahl an W{\"o}rtern neue Formen annehmen und mithin an neuem Leben und Bedeutung gewinnen, was sicherlich die allgemeinen Sprachmittel bereichern wird. Auf einer historischen Basis und mit Hilfe der Dekonstruktion wurden neue Formen der Ligaturen geschaffen — seltsame, kontroverse, auff{\"a}llige und einzigartige.}, language = {de} } @article{KezerashviliDachwald2021, author = {Kezerashvili, Roman Ya and Dachwald, Bernd}, title = {Preface: Solar sailing: Concepts, technology, and missions II}, series = {Advances in Space Research}, volume = {67}, journal = {Advances in Space Research}, number = {9}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0273-1177}, doi = {10.1016/j.asr.2021.01.037}, pages = {2559 -- 2560}, year = {2021}, language = {en} } @inproceedings{KernImaniVashianiTimmermanns2021, author = {Kern, Alexander and Imani Vashiani, Anahita and Timmermanns, Tobias}, title = {Threat for human beings due to touch voltages and body currents caused by direct lightning strikes in case of non-isolated lightning protection systems using natural components}, series = {35th International Conference on Lightning Protection (ICLP) and XVI International Symposium on Lightning Protection (SIPDA)}, booktitle = {35th International Conference on Lightning Protection (ICLP) and XVI International Symposium on Lightning Protection (SIPDA)}, publisher = {IEEE}, isbn = {978-1-6654-2346-5}, doi = {10.1109/ICLPandSIPDA54065.2021.9627465}, pages = {8 Seiten}, year = {2021}, abstract = {For typical cases of non-isolated lightning protection systems (LPS) the impulse currents are investigated which may flow through a human body directly touching a structural part of the LPS. Based on a basic LPS model with conventional down-conductors especially the cases of external and internal steel columns and metal fa{\c{c}}ades are considered and compared. Numerical simulations of the line quantities voltages and currents in the time domain are performed with an equivalent circuit of the entire LPS. As a result it can be stated that by increasing the number of conventional down-conductors and external steel columns the threat for a human being can indeed be reduced, but not down to an acceptable limit. In case of internal steel columns used as natural down-conductors the threat can be reduced sufficiently, depending on the low-resistive connection of the steel columns to the lightning equipotential bonding or the earth termination system, resp. If a metal fa{\c{c}}ade is used the threat for human beings touching is usually very low, if the fa{\c{c}}ade is sufficiently interconnected and multiply connected to the lightning equipotential bonding or the earth termination system, resp.}, language = {en} } @masterthesis{Kemmerling2021, type = {Bachelor Thesis}, author = {Kemmerling, Kristin}, title = {Zeitreisen: Interaktiv erlebbarer Raum zur Vermittlung von historischem Wissen}, publisher = {FH Aachen}, address = {Aachen}, school = {Fachhochschule Aachen}, pages = {60 Seiten}, year = {2021}, abstract = {Das Ziel des Konzeptes ist eine virtuelle personalisierte „Zeitreise" f{\"u}r die Besucher*innen zu gestalten. Die Ausstellung l{\"a}sst die Besucher*innen in ein vergangenes Zeitszenario eintauchen. Sie erleben und erkunden mit Hilfe von Computertechniken historische Ereignisse, w{\"a}hrend sie gleichzeitig n{\"u}tzliches Wissen vermittelt bekommen. Die Ausstellung besteht aus einer inszenierten interaktiven Raum-Installation mit 360 Grad Projektionen. Das 360 Grad Panorama erlaubt den Besucher*innen eine neue Art der Wahrnehmung von historischen Ereignissen. Alle Besucher*innen bekommen zu Beginn der Tour ein Smart Device (Tablet) mit einem vor installierten Benutzer Guide ausgeh{\"a}ndigt. Die Anwendungen sind Schritt f{\"u}r Schritt im Guide veranschaulicht und leicht anzuwenden. Sprachen, Schriften, Display Gr{\"o}ßen k{\"o}nnen jederzeit ge{\"a}ndert und Hilfe angefordert werden. Damit wird die Ausstellung barrierefrei. Mit Hilfe des neuen Benutzer Guides Systems sind alle Besucher*innen in der Lage vor der Tour eine kurze „Personalisierung" durchzuf{\"u}hren. Somit wird auf Basis der Interessenfelder eine individuelle „Zeitreise „ erm{\"o}glicht. Die dargestellten Szenarien k{\"o}nnen u.a. zwischen den historischen Maya Tempelruinen, Pyramiden, historischen Mythen, wie dem legend{\"a}ren Bernsteinzimmer variieren. Mit diesem Konzept ist es m{\"o}glich, l{\"a}ngst vergessene und zerst{\"o}rte Zeitszenarien zu rekonstruieren und diese mit Hilfe von Virtual Reality- und Augmented Reality Elementen interaktiv zu gestalten.}, language = {de} } @masterthesis{Kausen2021, type = {Bachelor Thesis}, author = {Kausen, Catharina Marie}, title = {Transmission: Ein animiertes Musikvideo illustriert die Liebe und Verbindung zum Genre Techno}, publisher = {FH Aachen}, address = {Aachen}, school = {Fachhochschule Aachen}, pages = {88 Seiten}, year = {2021}, abstract = {Techno ist seit seiner Entstehung mehr als ein Musik-Genre. Es ist ein Lebensgef{\"u}hl und eine Bewegung. Techno-Partys dienen vielen Menschen als Ventil, um die Sorgen des Alltags f{\"u}r eine Nacht vergessen zu k{\"o}nnen. „Transmission" portr{\"a}tiert anhand der Protagonistin die pers{\"o}nliche Beziehung zum Genre Techno. Das Musikvideo soll die Zuschauenden visuell anregen und mitreißen. Es bietet ihnen die M{\"o}glichkeit, sich selbst wieder erkennen zu k{\"o}nnen und soll Außenstehenden einen Einblick in die Techno-Szene erm{\"o}glichen. Mithilfe des Rotoskopie-Verfahrens konnte ein realistischer Animationsstil erreicht werden, welcher durch eine unrealistische Farbgebung der Charaktere gebrochen wird. Der Schwerpunkt der Bachelorarbeit liegt in der kreativ-gestalterischen Ausarbeitung. Die Musikvideo „Transmission" vermittelt das „Lebensgef{\"u}hl Techno" visuell anregend und nachvollziehbar.}, language = {de} } @article{KaschSchmidtJahnetal.2021, author = {Kasch, Susanne and Schmidt, Thomas and Jahn, Simon and Eichler, Fabian and Thurn, Laura and Bremen, Sebastian}, title = {L{\"o}sungsans{\"a}tze und Verfahrenskonzepte zum Laserstrahlschmelzen von Glas}, series = {Schweissen und Schneiden}, volume = {73}, journal = {Schweissen und Schneiden}, number = {Heft 1-2}, publisher = {DVS Verlag}, address = {D{\"u}sseldorf}, isbn = {0036-7184}, pages = {32 -- 39}, year = {2021}, language = {de} } @article{KarschuckKaulenPoghossianetal.2021, author = {Karschuck, Tobias and Kaulen, Corinna and Poghossian, Arshak and Wagner, Patrick H. and Sch{\"o}ning, Michael Josef}, title = {Gold nanoparticle-modified capacitive field-effect sensors: Studying the surface density of nanoparticles and coupling of charged polyelectrolyte macromolecules}, series = {Electrochemical Science Advances}, volume = {2}, journal = {Electrochemical Science Advances}, number = {5}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {0938-5193}, doi = {10.1002/elsa.202100179}, pages = {10 Seiten}, year = {2021}, abstract = {The coupling of ligand-stabilized gold nanoparticles with field-effect devices offers new possibilities for label-free biosensing. In this work, we study the immobilization of aminooctanethiol-stabilized gold nanoparticles (AuAOTs) on the silicon dioxide surface of a capacitive field-effect sensor. The terminal amino group of the AuAOT is well suited for the functionalization with biomolecules. The attachment of the positively-charged AuAOTs on a capacitive field-effect sensor was detected by direct electrical readout using capacitance-voltage and constant capacitance measurements. With a higher particle density on the sensor surface, the measured signal change was correspondingly more pronounced. The results demonstrate the ability of capacitive field-effect sensors for the non-destructive quantitative validation of nanoparticle immobilization. In addition, the electrostatic binding of the polyanion polystyrene sulfonate to the AuAOT-modified sensor surface was studied as a model system for the label-free detection of charged macromolecules. Most likely, this approach can be transferred to the label-free detection of other charged molecules such as enzymes or antibodies.}, language = {en} }