@article{MonakhovaDiehl2021, author = {Monakhova, Yulia and Diehl, Bernd W. K.}, title = {A step towards optimization of the qNMR workflow: proficiency testing exercise at an GxP-accredited laboratory}, series = {Applied Magnetic Resonance}, volume = {52}, journal = {Applied Magnetic Resonance}, publisher = {Springer Nature}, address = {Wien}, issn = {1613-7507}, doi = {10.1007/s00723-021-01324-3}, pages = {581 -- 593}, year = {2021}, abstract = {Quantitative nuclear magnetic resonance (qNMR) is considered as a powerful tool for multicomponent mixture analysis as well as for the purity determination of single compounds. Special attention is currently paid to the training of operators and study directors involved in qNMR testing. To assure that only qualified personnel are used for sample preparation at our GxP-accredited laboratory, weighing test was proposed. Sixteen participants performed six-fold weighing of the binary mixture of dibutylated hydroxytoluene (BHT) and 1,2,4,5-tetrachloro-3-nitrobenzene (TCNB). To evaluate the quality of data analysis, all spectra were evaluated manually by a qNMR expert and using in-house developed automated routine. The results revealed that mean values are comparable and both evaluation approaches are free of systematic error. However, automated evaluation resulted in an approximately 20\% increase in precision. The same findings were revealed for qNMR analysis of 32 compounds used in pharmaceutical industry. Weighing test by six-fold determination in binary mixtures and automated qNMR methodology can be recommended as efficient tools for evaluating staff proficiency. The automated qNMR method significantly increases throughput and precision of qNMR for routine measurements and extends application scope of qNMR.}, language = {en} } @article{MolinnusSorichBartzetal.2016, author = {Molinnus, Denise and Sorich, Maren and Bartz, Alexander and Siegert, Petra and Willenberg, Holger S. and Lisdat, Fred and Poghossian, Arshak and Keusgen, Michael and Sch{\"o}ning, Michael Josef}, title = {Towards an adrenaline biosensor based on substrate recycling amplification in combination with an enzyme logic gate}, series = {Sensors and Actuators B: Chemical}, volume = {237}, journal = {Sensors and Actuators B: Chemical}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0925-4005}, doi = {10.1016/j.snb.2016.06.064}, pages = {190 -- 195}, year = {2016}, abstract = {An amperometric biosensor using a substrate recycling principle was realized for the detection of low adrenaline concentrations (1 nM) by measurements in phosphate buffer and Ringer's solution at pH 6.5 and pH 7.4, respectively. In proof-of-concept experiments, a Boolean logic-gate principle has been applied to develop a digital adrenaline biosensor based on an enzyme AND logic gate. The obtained results demonstrate that the developed digital biosensor is capable for a rapid qualitative determination of the presence/absence of adrenaline in a YES/NO statement. Such digital biosensor could be used in clinical diagnostics for the control of a correct insertion of a catheter in the adrenal veins during adrenal venous-sampling procedure.}, language = {en} } @article{MolinnusMuschallikGonzalezetal.2018, author = {Molinnus, Denise and Muschallik, Lukas and Gonzalez, Laura Osorio and Bongaerts, Johannes and Wagner, Torsten and Selmer, Thorsten and Siegert, Petra and Keusgen, Michael and Sch{\"o}ning, Michael Josef}, title = {Development and characterization of a field-effect biosensor for the detection of acetoin}, series = {Biosensors and Bioelectronics}, volume = {115}, journal = {Biosensors and Bioelectronics}, publisher = {Elsevier}, address = {Amsterdam}, doi = {10.1016/j.bios.2018.05.023}, pages = {1 -- 6}, year = {2018}, abstract = {A capacitive electrolyte-insulator-semiconductor (EIS) field-effect biosensor for acetoin detection has been presented for the first time. The EIS sensor consists of a layer structure of Al/p-Si/SiO₂/Ta₂O₅/enzyme acetoin reductase. The enzyme, also referred to as butane-2,3-diol dehydrogenase from B. clausii DSM 8716T, has been recently characterized. The enzyme catalyzes the (R)-specific reduction of racemic acetoin to (R,R)- and meso-butane-2,3-diol, respectively. Two different enzyme immobilization strategies (cross-linking by using glutaraldehyde and adsorption) have been studied. Typical biosensor parameters such as optimal pH working range, sensitivity, hysteresis, linear concentration range and long-term stability have been examined by means of constant-capacitance (ConCap) mode measurements. Furthermore, preliminary experiments have been successfully carried out for the detection of acetoin in diluted white wine samples.}, language = {en} } @article{MolinnusBaeckerSiegertetal.2015, author = {Molinnus, Denise and B{\"a}cker, Matthias and Siegert, Petra and Willenberg, H. and Poghossian, Arshak and Keusgen, M. and Sch{\"o}ning, Michael Josef}, title = {Detection of Adrenaline Based on Substrate Recycling Amplification}, series = {Procedia Engineering}, volume = {120}, journal = {Procedia Engineering}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1877-7058}, doi = {10.1016/j.proeng.2015.08.708}, pages = {540 -- 543}, year = {2015}, abstract = {An amperometric enzyme biosensor has been applied for the detection of adrenaline. The adrenaline biosensor has been prepared by modification of an oxygen electrode with the enzyme laccase that operates at a broad pH range between pH 3.5 to pH 8. The enzyme molecules were immobilized via cross-linking with glutaraldehyde. The sensitivity of the developed adrenaline biosensor in different pH buffer solutions has been studied.}, language = {en} } @article{MichalakNacerddinePietersenetal.2013, author = {Michalak, Ewa Malgorzata and Nacerddine, Karim and Pietersen, Alexandra and Beuger, Vincent and Pawlitzky, Inka and Cornelissen-Steijger, Paulien and Wientjens, Ellen and Tanger, Ellen and Seibler, Jost and Lohuizen, Maarten van and Jonkers, Jos}, title = {Polycomb group gene Ezh2 regulates mammary gland morphogenesis and maintains the luminal progenitor pool}, series = {Stem Cells}, volume = {Vol 31}, journal = {Stem Cells}, number = {9}, publisher = {Oxford University Press}, address = {Oxford}, issn = {1549-4918}, doi = {10.1002/stem.1437}, pages = {1910 -- 1920}, year = {2013}, language = {en} } @article{MeyerStorkKalbeKuropkaetal.1988, author = {Meyer-Stork, L. Sebastian and Kalbe, Jochen and Kuropka, Rolf and Sauter, S. L. and H{\"o}cker, Hartwig and Berndt, Heinz}, title = {Eindeutige Provenienzanalyse von Wolle und feinen Tierhaaren mit Hilfe der Erbsubstanz (DNS)}, series = {Textilveredlung : schweizerische Zeitschrift f{\"u}r Textilchemie, Textilveredlung und deren Randgebiete}, volume = {23}, journal = {Textilveredlung : schweizerische Zeitschrift f{\"u}r Textilchemie, Textilveredlung und deren Randgebiete}, number = {9}, issn = {0040-5310}, pages = {304 -- 307}, year = {1988}, language = {de} } @article{MeyerStorkHoeckerBerndt1992, author = {Meyer-Stork, L. Sebastian and H{\"o}cker, Hartwig and Berndt, Heinz}, title = {Syntheses and reactions of urethanes of cellobiose and cellulose-containing uretdione groups}, series = {Journal of applied polymer science}, volume = {44}, journal = {Journal of applied polymer science}, number = {6}, issn = {1097-4628}, pages = {1043 -- 1049}, year = {1992}, language = {en} } @article{MeyerHentschkeHageretal.2017, author = {Meyer, Jan and Hentschke, Reinhard and Hager, Jonathan and Hojdis, Nils and Karimi-Varzaneh, Hossein Ali}, title = {Molecular Simulation of Viscous Dissipation due to Cyclic Deformation of a Silica-Silica Contact in Filled Rubber}, series = {Macromolecules}, volume = {50}, journal = {Macromolecules}, number = {17}, issn = {1520-5835}, doi = {10.1021/acs.macromol.7b00947}, pages = {6679 -- 6689}, year = {2017}, language = {en} } @article{MerschenzQuackMootz1988, author = {Merschenz-Quack, Angelika and Mootz, D.}, title = {Structures of thionyl halides: SOCl2 and SOBr2 / Mootz, D. ; Merschenz-Quack, A.}, series = {Acta crystallographica / Section C, Crystal structure communications. C 44 (1988), H. 5}, journal = {Acta crystallographica / Section C, Crystal structure communications. C 44 (1988), H. 5}, isbn = {0108-2701}, pages = {926 -- 927}, year = {1988}, language = {en} } @article{MerschenzQuackMootz1988, author = {Merschenz-Quack, Angelika and Mootz, D.}, title = {Structures of sulfuryl halides: SO2F2, SO2CIF and SO2Cl2 / Mootz, D. ; Merschenz-Quack, A.}, series = {Acta crystallographica / Section C, Crystal structure communications. C 44 (1988), H. 5}, journal = {Acta crystallographica / Section C, Crystal structure communications. C 44 (1988), H. 5}, isbn = {0108-2701}, pages = {924 -- 925}, year = {1988}, language = {en} } @article{MerschenzQuackMootz1990, author = {Merschenz-Quack, Angelika and Mootz, D.}, title = {Structure of 5-sulfosalicylic acid pentahydrate}, series = {Acta crystallographica / Section C, Crystal structure communications. C 46 (1990), H. 8}, journal = {Acta crystallographica / Section C, Crystal structure communications. C 46 (1990), H. 8}, isbn = {0108-2701}, pages = {1478 -- 1480}, year = {1990}, language = {en} } @article{MerschenzQuackHemmerlingWunderlich2004, author = {Merschenz-Quack, Angelika and Hemmerling, Hans-J{\"o}rg and Wunderlich, Hartmut}, title = {1,2-Deoxygenation of vic-Dihydroxyindenoimidazoles: Optimization of a Novel Deoxygenation Reagent. I. / Hemmerling, Hans-J{\"o}rg ; Merschenz-Quack, Angelika ; Wunderlich, Hartmut}, series = {Zeitschrift f{\"u}r Naturforschung B. 59 (2004), H. 10}, journal = {Zeitschrift f{\"u}r Naturforschung B. 59 (2004), H. 10}, isbn = {0932-0776}, pages = {1143 -- 1152}, year = {2004}, language = {en} } @book{MerschenzQuack1976, author = {Merschenz-Quack, Angelika}, title = {Untersuchungen zum Stoffwechsel menschlicher Thrombozyten in der Ur{\"a}mie / Angelika Merschenz ; Darge, Walter [Betreuer]}, year = {1976}, language = {de} } @book{MerschenzQuack1983, author = {Merschenz-Quack, Angelika}, title = {Untersuchungen an Systemen mit Wasserstoffbr{\"u}cken / Angelika Merschenz}, address = {D{\"u}sseldorf}, pages = {68 Bl.}, year = {1983}, language = {de} } @book{MerschenzQuack1987, author = {Merschenz-Quack, Angelika}, title = {Halogenide und Hydrate von Oxos{\"a}uren des Schwefels : Beitr. zur Kristall- u. Strukturchemie}, address = {D{\"u}sseldorf}, pages = {104 S. : zahlr. Ill., graph. Darst.}, year = {1987}, language = {de} } @article{MerschenzQuack1991, author = {Merschenz-Quack, Angelika}, title = {Betriebsanweisungen beim Umgang mit Gefahrstoffen}, series = {Elektro-Praktiker : Fachzeitschrift f{\"u}r Handwerk und Industrie}, volume = {Bd. 45}, journal = {Elektro-Praktiker : Fachzeitschrift f{\"u}r Handwerk und Industrie}, number = {H. 10}, issn = {0013-5569}, pages = {644 -- 649}, year = {1991}, language = {de} } @misc{MerkelWeberSiegertetal.2006, author = {Merkel, Marion and Weber, Angrit and Siegert, Petra and Wieland, Susanne and Maurer, Karl-Heinz and Bessler, Cornelius}, title = {Neue Alkalische Protease aus Bacillus gibsonii und Wasch- und Reinigungsmittel enthaltend diese neue Alkalische Protease [Offenlegungsschrift]}, publisher = {Deutsches Patent- und Markenamt / WIPO}, address = {M{\"u}nchen / Genf}, pages = {1 -- 46}, year = {2006}, language = {de} } @article{MeinersBaumann1997, author = {Meiners, Klaus and Baumann, Marcus}, title = {Lokale Beitr{\"a}ge zum globalen Klimaschutz}, series = {Wechselwirkung : Wissenschaft \& vernetztes Denken}, volume = {19}, journal = {Wechselwirkung : Wissenschaft \& vernetztes Denken}, number = {84}, issn = {0172-1623}, pages = {6 -- 12}, year = {1997}, language = {de} } @article{MedlinLangeBaumann1994, author = {Medlin, L. K. and Lange, M. and Baumann, Marcus}, title = {Genetic differentiation among three colony-forming species of Phaeocystis : further evidence for the phylogeny of the Prymnesiophyta}, series = {Phycologia}, volume = {Vol. 33}, journal = {Phycologia}, number = {Iss. 3}, issn = {0031-8884}, pages = {199 -- 212}, year = {1994}, language = {en} } @incollection{MedlinBarkerBaumannetal.1994, author = {Medlin, L. K. and Barker, G. L. A. and Baumann, Marcus and Hayes, P. K.}, title = {Molecular biology and systematics}, series = {The Haptophyte Algae (Special volume / Systematics Association : 51)}, booktitle = {The Haptophyte Algae (Special volume / Systematics Association : 51)}, publisher = {Clarendon Press}, address = {Oxford}, isbn = {0-19-857772-9}, pages = {393 -- 411}, year = {1994}, language = {en} }