@article{DammErlerHillenetal.2011, author = {Damm, Alexander and Erler, Andr{\´e} and Hillen, Walter and Meroni, Michele and Schaepman, Michael E. and Verhoef, Wout and Rascher, Uwe}, title = {Modeling the impact of spectral sensor configurations on the FLD retrieval accuracy of sun-induced chlorophyll fluorescence}, series = {Remote Sensing of Environment}, volume = {115}, journal = {Remote Sensing of Environment}, number = {8}, publisher = {Elsevier}, address = {Amsterdam}, isbn = {0034-4257}, pages = {1882 -- 1892}, year = {2011}, language = {en} } @article{DallasSalphatiGomezZepedaetal.2016, author = {Dallas, Shannon and Salphati, Laurent and Gomez-Zepeda, David and Wanek, Thomas and Chen, Liangfu and Chu, Xiaoyan and Kunta, Jeevan and Mezler, Mario and Menet, Marie-Claude and Chasseigneaux, Stephanie and Decl{\`e}ves, Xavier and Langer, Oliver and Pierre, Esaie and DiLoreto, Karen and Hoft, Carolin and Laplanche, Loic and Pang, Jodie and Pereira, Tony and Andonian, Clara and Simic, Damir and Rode, Anja and Yabut, Jocelyn and Zhang, Xiaolin and Scheer, Nico}, title = {Generation and Characterization of a Breast Cancer Resistance Protein Humanized Mouse Model}, series = {Molecular Pharmacology}, volume = {89}, journal = {Molecular Pharmacology}, number = {5}, publisher = {ASPET}, address = {Bethesda, Md.}, issn = {1521-0111}, doi = {10.1124/mol.115.102079}, pages = {492 -- 504}, year = {2016}, abstract = {Breast cancer resistance protein (BCRP) is expressed in various tissues, such as the gut, liver, kidney and blood brain barrier (BBB), where it mediates the unidirectional transport of substrates to the apical/luminal side of polarized cells. Thereby BCRP acts as an efflux pump, mediating the elimination or restricting the entry of endogenous compounds or xenobiotics into tissues and it plays important roles in drug disposition, efficacy and safety. Bcrp knockout mice (Bcrp-/-) have been used widely to study the role of this transporter in limiting intestinal absorption and brain penetration of substrate compounds. Here we describe the first generation and characterization of a mouse line humanized for BCRP (hBCRP), in which the mouse coding sequence from the start to stop codon was replaced with the corresponding human genomic region, such that the human transporter is expressed under control of the murine Bcrp promoter. We demonstrate robust human and loss of mouse BCRP/Bcrp mRNA and protein expression in the hBCRP mice and the absence of major compensatory changes in the expression of other genes involved in drug metabolism and disposition. Pharmacokinetic and brain distribution studies with several BCRP probe substrates confirmed the functional activity of the human transporter in these mice. Furthermore, we provide practical examples for the use of hBCRP mice to study drug-drug interactions (DDIs). The hBCRP mouse is a promising model to study the in vivo role of human BCRP in limiting absorption and BBB penetration of substrate compounds and to investigate clinically relevant DDIs involving BCRP.}, language = {en} } @inproceedings{DalguerChurilovButenwegetal.2014, author = {Dalguer, Luis A. and Churilov, Sergey and Butenweg, Christoph and Renault, Philippe and Hyun, An Jun}, title = {Dynamic analysis of a reinforced concrete electrical nuclear building of SMART 2013 project subjected to earthquake excitation using ABAQUS}, series = {Workshop SMART2013 : Paris, France, November 25th - 27th, 2014}, booktitle = {Workshop SMART2013 : Paris, France, November 25th - 27th, 2014}, organization = {Workshop SMART2013 <2014, Paris>}, pages = {1 -- 12}, year = {2014}, language = {en} } @phdthesis{DahmenBeumers2005, author = {Dahmen-Beumers, Judith}, title = {Eine exemplarische Untersuchung zur Regionalit{\"a}t in der Kunst : der Aachener Bildhauer und Maler Benno Werth (*1929)}, publisher = {Books on Demand}, address = {Norderstedt}, isbn = {3-8334-3014-1}, pages = {IV, 297 Seiten}, year = {2005}, language = {de} } @article{DahmannMager1994, author = {Dahmann, Peter and Mager, M.}, title = {Einfluß der Zusammensetzung der abzuscheidenden Verschmutzung auf die Abscheideleistung von Hydraulikfiltern}, series = {{\"O}lhydraulik und Pneumatik. 38 (1994), H. 4}, journal = {{\"O}lhydraulik und Pneumatik. 38 (1994), H. 4}, isbn = {0341-2660}, pages = {212 -- 214}, year = {1994}, language = {de} } @article{DahmannHagemeisterNageletal.2006, author = {Dahmann, Peter and Hagemeister, Wilhelm and Nagel, G{\"u}nther and Exner, Peter}, title = {Geregelte Innenzahnradpumpe im Mehrquadrantenbetrieb Geschwindigkeits- und Positionsregelung eines hydraulischen Handlingger{\"a}tes}, series = {O+P {\"O}lhydraulik und Pneumatik. 24 (2006), H. 1}, journal = {O+P {\"O}lhydraulik und Pneumatik. 24 (2006), H. 1}, isbn = {0341-2660}, pages = {24 -- 28}, year = {2006}, language = {de} } @article{DahmannHagemeisterNageletal.2002, author = {Dahmann, Peter and Hagemeister, W. and Nagel, and Exner,}, title = {Geschwindigkeits- und Positionsregelung eines hydraulischen Handlingger{\"a}tes in einem Ziegelwerk durch frequenzgeregelte Innenzahnradpumpe im Mehrquadrantenbetrieb}, series = {Fluid power focused on applications : 3rd International Fluid Power Conference (3rd IFK) ; [conference proceedings, March 5th and 6th 2002, Aachen, Germany]. Fluidtechnik, Band T3}, journal = {Fluid power focused on applications : 3rd International Fluid Power Conference (3rd IFK) ; [conference proceedings, March 5th and 6th 2002, Aachen, Germany]. Fluidtechnik, Band T3}, publisher = {Shaker}, address = {Aachen}, isbn = {3-8265-9900-4}, pages = {83 -- 94}, year = {2002}, language = {de} } @article{Dahmann1995, author = {Dahmann, Peter}, title = {Offen f{\"u}r neue Modelle. GL-Hydraulik setzt neues Simulationssystem ein}, series = {Fluid Heft Sonderpublikation Fluid-Technik. 29 (1995)}, journal = {Fluid Heft Sonderpublikation Fluid-Technik. 29 (1995)}, isbn = {0015-461X}, pages = {8 -- 10}, year = {1995}, language = {de} } @phdthesis{Dahmann1992, author = {Dahmann, Peter}, title = {Untersuchungen zur Wirksamkeit von Filtern in hydraulischen Anlagen}, pages = {VI, 160 S. : Ill., graph. Darst.}, year = {1992}, language = {de} } @article{Dahmann1990, author = {Dahmann, Peter}, title = {Leistungsf{\"a}higkeit von Hydraulikfiltern bei unterschiedlichen Betriebsbedingungen}, series = {{\"O}lhydraulik und Pneumatik. 34 (1990), H. 10}, journal = {{\"O}lhydraulik und Pneumatik. 34 (1990), H. 10}, isbn = {0341-2660}, pages = {682 -- 688}, year = {1990}, language = {de} } @inproceedings{Dahmann2011, author = {Dahmann, Peter}, title = {Stemme S10 VTX als multifunktionales Forschungsflugzeug}, series = {Deutscher Luft- und Raumfahrtkongress 2011 : Bremen, 27. bis 29. September 2011 ; Tagungsband}, booktitle = {Deutscher Luft- und Raumfahrtkongress 2011 : Bremen, 27. bis 29. September 2011 ; Tagungsband}, publisher = {Dt. Gesellschaft f{\"u}r Luft- und Raumfahrt}, address = {Bonn}, isbn = {978-3-9321-8274-7}, pages = {357 -- 364}, year = {2011}, language = {de} } @article{Dahmann1993, author = {Dahmann, Peter}, title = {Funktionsweise von Hydraulikfiltern}, series = {{\"O}lhydraulik und Pneumatik. 37 (1993), H. 2}, journal = {{\"O}lhydraulik und Pneumatik. 37 (1993), H. 2}, isbn = {0341-2660}, pages = {118 -- 122}, year = {1993}, language = {de} } @article{DahlSuttrop1998, author = {Dahl, G{\"u}nter and Suttrop, F.}, title = {Engine control and low-NO(x) combustion for hydrogen fuelled aircraft gas turbines}, series = {International Journal of Hydrogen Energy. 23 (1998), H. 8}, journal = {International Journal of Hydrogen Energy. 23 (1998), H. 8}, isbn = {0360-3199}, pages = {695 -- 704}, year = {1998}, language = {en} } @article{DadfarCamozziDarguzyteetal.2020, author = {Dadfar, Dryed Mohammadali and Camozzi, Denise and Darguzyte, Milita and Roemhild, Karolin and Varvar{\`a}, Paola and Metselaar, Josbert and Banala, Srinivas and Straub, Marcel and G{\"u}ver, Nihan and Engelmann, Ulrich M. and Slabu, Ioana and Buhl, Miriam and Leusen, Jan van and K{\"o}gerler, Paul and Hermanns-Sachweh, Benita and Schulz, Volkmar and Kiessling, Fabian and Lammers, Twan}, title = {Size-isolation of superparamagnetic iron oxide nanoparticles improves MRI, MPI and hyperthermia performance}, series = {Journal of Nanobiotechnology}, volume = {18}, journal = {Journal of Nanobiotechnology}, number = {Article number 22}, publisher = {Nature Portfolio}, issn = {1477-3155}, doi = {10.1186/s12951-020-0580-1}, pages = {1 -- 13}, year = {2020}, abstract = {Superparamagnetic iron oxide nanoparticles (SPION) are extensively used for magnetic resonance imaging (MRI) and magnetic particle imaging (MPI), as well as for magnetic fluid hyperthermia (MFH). We here describe a sequential centrifugation protocol to obtain SPION with well-defined sizes from a polydisperse SPION starting formulation, synthesized using the routinely employed co-precipitation technique. Transmission electron microscopy, dynamic light scattering and nanoparticle tracking analyses show that the SPION fractions obtained upon size-isolation are well-defined and almost monodisperse. MRI, MPI and MFH analyses demonstrate improved imaging and hyperthermia performance for size-isolated SPION as compared to the polydisperse starting mixture, as well as to commercial and clinically used iron oxide nanoparticle formulations, such as Resovist® and Sinerem®. The size-isolation protocol presented here may help to identify SPION with optimal properties for diagnostic, therapeutic and theranostic applications.}, language = {en} } @inproceedings{DachwaldXuFeldmannetal.2011, author = {Dachwald, Bernd and Xu, Changsheng and Feldmann, Marco and Plescher, Engelbert}, title = {IceMole : Development of a novel subsurface ice probe and testing of the first prototype on the Morteratsch Glacier}, series = {EGU General Assembly 2011 Vienna | Austria | 03 - 08 April 2011}, booktitle = {EGU General Assembly 2011 Vienna | Austria | 03 - 08 April 2011}, year = {2011}, abstract = {We present the novel concept of a combined drilling and melting probe for subsurface ice research. This probe, named "IceMole", is currently developed, built, and tested at the FH Aachen University of Applied Sciences' Astronautical Laboratory. Here, we describe its first prototype design and report the results of its field tests on the Swiss Morteratsch glacier. Although the IceMole design is currently adapted to terrestrial glaciers and ice shields, it may later be modified for the subsurface in-situ investigation of extraterrestrial ice, e.g., on Mars, Europa, and Enceladus. If life exists on those bodies, it may be present in the ice (as life can also be found in the deep ice of Earth).}, language = {en} } @article{DachwaldWurm2011, author = {Dachwald, Bernd and Wurm, Patrick}, title = {Mission analysis and performance comparison for an Advanced Solar Photon Thruster}, series = {Advances in Space Research}, volume = {48}, journal = {Advances in Space Research}, number = {11}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0273-1177}, pages = {1858 -- 1868}, year = {2011}, language = {en} } @inproceedings{DachwaldWurm2009, author = {Dachwald, Bernd and Wurm, P.}, title = {Design concept and modeling of an advanced solar photon thruster}, series = {Advances in the Astronautical Sciences}, booktitle = {Advances in the Astronautical Sciences}, publisher = {American Astronautical Society}, address = {San Diego, Calif.}, isbn = {978-087703554-1}, issn = {00653438}, pages = {723 -- 740}, year = {2009}, abstract = {The so-called "compound solar sail", also known as "Solar Photon Thruster" (SPT), holds the potential of providing significant performance advantages over the flat solar sail. Previous SPT design concepts, however, do not consider shadowing effects and multiple reflections of highly concentrated solar radiation that would inevitably destroy the gossamer sail film. In this paper, we propose a novel advanced SPT (ASPT) design concept that does not suffer from these oversimplifications. We present the equations that describe the thrust force acting on such a sail system and compare its performance with respect to the conventional flat solar sail.}, language = {en} } @inproceedings{DachwaldWurm2009, author = {Dachwald, Bernd and Wurm, P.}, title = {Mission analysis for an advanced solar photon thruster}, series = {60th International Astronautical Congress 2009, IAC 2009}, volume = {8}, booktitle = {60th International Astronautical Congress 2009, IAC 2009}, publisher = {Elsevier}, address = {Amsterdam}, isbn = {978-161567908-9}, pages = {6838 -- 6851}, year = {2009}, abstract = {The so-called "compound solar sail", also known as "Solar Photon Thruster" (SPT), is a solar sail design concept, for which the two basic functions of the solar sail, namely light collection and thrust direction, are uncoupled. In this paper, we introduce a novel SPT concept, termed the Advanced Solar Photon Thruster (ASPT). This model does not suffer from the simplified assumptions that have been made for the analysis of compound solar sails in previous studies. We present the equations that describe the force, which acts on the ASPT. After a detailed design analysis, the performance of the ASPT with respect to the conventional flat solar sail (FSS) is investigated for three interplanetary mission scenarios: An Earth-Venus rendezvous, where the solar sail has to spiral towards the Sun, an Earth-Mars rendezvous, where the solar sail has to spiral away from the Sun, and an Earth-NEA rendezvous (to near-Earth asteroid 1996FG3), where a large orbital eccentricity change is required. The investigated solar sails have realistic near-term characteristic accelerations between 0.1 and 0.2mm/s2. Our results show that a SPT is not superior to the flat solar sail unless very idealistic assumptions are made.}, language = {en} } @article{DachwaldWie2005, author = {Dachwald, Bernd and Wie, Bong}, title = {Solar Sail Trajectory Optimization for Intercepting, Impacting, and Deflecting Near-Earth Asteroids}, series = {AIAA Guidance, Navigation and Control Conference and Exhibit - AIAA Modeling and Simulation Technologies Conference and Exhibit - AIAA Atmospheric Flight Mechanics Conference and Exhibit : [San Francisco, California, 15 - 18 August 2005 ; papers]. - (AIAA meeting papers on disc ; [10.]2005,16-17)}, journal = {AIAA Guidance, Navigation and Control Conference and Exhibit - AIAA Modeling and Simulation Technologies Conference and Exhibit - AIAA Atmospheric Flight Mechanics Conference and Exhibit : [San Francisco, California, 15 - 18 August 2005 ; papers]. - (AIAA meeting papers on disc ; [10.]2005,16-17)}, publisher = {American Institute of Aeronautics and Astronautics}, address = {Reston, Va.}, isbn = {1-56347-765-3}, pages = {2 CD-ROMs}, year = {2005}, language = {en} } @article{DachwaldWi2007, author = {Dachwald, Bernd and Wi, Bong}, title = {Solar Sail Kinetic Energy Impactor Trajectory Optimization for an Asteroid-Deflection Mission}, series = {Journal of Spacecraft and Rockets. 44 (2007), H. 4}, journal = {Journal of Spacecraft and Rockets. 44 (2007), H. 4}, isbn = {0022-4650}, pages = {755 -- 764}, year = {2007}, language = {en} }