@article{OosterhuisOehlschlaegerBergetal.2011, author = {Oosterhuis, Koen and {\"O}hlschl{\"a}ger, Peter and Berg, Joost H. van den and Toebes, Mireille and Gomez, Raquel and Schumacher, Ton N. and Haanen, John B.}, title = {Preclinical development of highly effective and safe DNA vaccines directed against HPV 16 E6 and E7}, series = {International Journal of Cancer}, volume = {129}, journal = {International Journal of Cancer}, number = {2}, publisher = {Wiley}, address = {Weinheim}, isbn = {1097-0215}, pages = {397 -- 406}, year = {2011}, language = {en} } @article{HenkenOosterhuisOehlschlaegeretal.2012, author = {Henken, F. E. and Oosterhuis, K. and {\"O}hlschl{\"a}ger, Peter and Bosch, L. and Hooijberg, E. and Haanen, J. B. A. G. and Steenbergen, R. D. M.}, title = {Preclinical safety evaluation of DNA vaccines encoding modified HPV16 E6 and E7}, series = {Vaccine}, volume = {30}, journal = {Vaccine}, number = {28}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0264-410X}, doi = {10.1016/j.vaccine.2012.04.013}, pages = {4259 -- 4266}, year = {2012}, abstract = {Persistent infection with high-risk human papillomaviruses (hrHPV) can result in the formation of anogenital cancers. As hrHPV proteins E6 and E7 are required for cancer initiation and maintenance, they are ideal targets for immunotherapeutic interventions. Previously, we have described the development of DNA vaccines for the induction of HPV16 E6 and E7 specific T cell immunity. These vaccines consist of 'gene-shuffled' (SH) versions of HPV16 E6 and E7 that were fused to Tetanus Toxin Fragment C domain 1 (TTFC) and were named TTFC-E6SH and TTFC-E7SH. Gene-shuffling was performed to avoid the risk of inducing malignant transformation at the vaccination site. Here, we describe the preclinical safety evaluation of these candidate vaccines by analysis of their transforming capacity in vitro using established murine fibroblasts (NIH 3T3 cells) and primary human foreskin keratinocytes (HFKs). We demonstrate that neither ectopic expression of TTFC-E6SH and TTFC-E7SH alone or in combination enabled NIH 3T3 cells to form colonies in soft agar. In contrast, expression of HPV16 E6WT and E7WT alone or in combination resulted in effective transformation. Similarly, retroviral transduction of HFKs from three independent donors with both TTFC-E6SH and TTFC-E7SH alone or in combination did not show any signs of immortalization. In contrast, the combined expression of E6WT and E7WT induced immortalization in HFKs from all donors. Based on these results we consider it justified to proceed to clinical evaluation of DNA vaccines encoding TTFC-E6SH and TTFC-E7SH in patients with HPV16 associated (pre)malignancies.}, language = {en} } @article{BiselliSchmidWandrey1988, author = {Biselli, Manfred and Schmid, Georg and Wandrey, Christian}, title = {Preparation of cellodextrins and isolation of oligomeric side components and their characterization / Schmid, Georg ; Biselli, Manfred ; Wandrey, Christian}, series = {Analytical Biochemistry. 175 (1988)}, journal = {Analytical Biochemistry. 175 (1988)}, isbn = {0003-2697}, pages = {573 -- 583}, year = {1988}, language = {en} } @article{KotterHammon1986, author = {Kotter, Michael and Hammon, U.}, title = {Preparation of pellets with well-defined pore structure / U. Hammon ; A. Kotter}, series = {International chemical engineering. 26 (1986), H. 4}, journal = {International chemical engineering. 26 (1986), H. 4}, isbn = {0020-6318}, pages = {563 -- 573}, year = {1986}, language = {en} } @article{NaithaniKlostermeyerLangeetal.1971, author = {Naithani, V. K and Klostermeyer, Henning and Lange, H. R. and [u.a.], and Berndt, Heinz and [u.a.],}, title = {Preparation of peptide derivatives for porcine proinsulin-synthesis}, series = {Biological Chemistry}, volume = {352}, journal = {Biological Chemistry}, number = {1}, publisher = {De Gruyter}, issn = {1437-4315}, doi = {10.1515/bchm2.1971.352.1.1}, pages = {2 -- 3}, year = {1971}, language = {en} } @article{PrielmeierWoznyjLuedemann1984, author = {Prielmeier, Franz and Woznyj, M. and L{\"u}demann, H.-D.}, title = {Pressure Dependence of the Melting and Self Diffusion in 2,2-Dimethylpropane, 2,2-Dimethylpropionitrile, and 2-Methylpropanol-2 / M. Woznyj, F. X. Prielmeier, H.-D. L{\"u}demann}, series = {Zeitschrift f{\"u}r Naturforschung A, Journal of Physical Sciences. 39 (1984)}, journal = {Zeitschrift f{\"u}r Naturforschung A, Journal of Physical Sciences. 39 (1984)}, isbn = {0932-0784}, pages = {800}, year = {1984}, language = {en} } @article{PrielmeierLangLuedemann1984, author = {Prielmeier, Franz and Lang, E. W. and L{\"u}demann, H.-D.}, title = {Pressure dependence of the self-diffusion in liquid trifluoromethane / F. X. Prielmeier; E. W. Lang; H.-D. L{\"u}demann}, series = {Molecular Physics. 52 (1984), H. 5}, journal = {Molecular Physics. 52 (1984), H. 5}, isbn = {0026-8976}, pages = {1105 -- 1113}, year = {1984}, language = {en} } @article{KotterRiekertSimoncic1986, author = {Kotter, Michael and Riekert, Lothar and Simoncic, V.}, title = {Pristup sintezi industrijskih katalizatora}, series = {Kemija u industriji : casopis kemicara i tehnologa Jugoslavije. 35 (1986)}, journal = {Kemija u industriji : casopis kemicara i tehnologa Jugoslavije. 35 (1986)}, isbn = {0022-9830}, pages = {79 -- 86}, year = {1986}, language = {de} } @article{ElbersMuratyan1991, author = {Elbers, Gereon and Muratyan, Simone}, title = {Problematik verkehrsbezogener Außenluftmessungen von Partikeln (Dieselruß)}, series = {+ Krebserzeugende Stoffe in der Umwelt : Herkunft, Messung, Risiko, Minimierung ; Kolloquium Mannheim, 23. bis 25. April 1991 / Kommission Reinhaltung der Luft im VDI und DIN}, journal = {+ Krebserzeugende Stoffe in der Umwelt : Herkunft, Messung, Risiko, Minimierung ; Kolloquium Mannheim, 23. bis 25. April 1991 / Kommission Reinhaltung der Luft im VDI und DIN}, publisher = {VDI-Verl.}, address = {D{\"u}sseldorf}, isbn = {3-18-090888-2}, pages = {143}, year = {1991}, language = {de} } @article{TuegBaumann1994, author = {T{\"u}g, Helmut and Baumann, Marcus}, title = {Problems of UV-B radiation measurements in biological research : critical remarks on current techniques and suggestions for improvements}, series = {Geophysical research letters}, volume = {Vol. 21}, journal = {Geophysical research letters}, number = {Iss. 8}, issn = {1944-8007 (E-Journal); 0094-8276 (Print)}, pages = {689 -- 692}, year = {1994}, language = {en} } @article{GerigkBujnickiGanpoNkwenkwaetal.2002, author = {Gerigk, M. and Bujnicki, R. and Ganpo-Nkwenkwa, E. and Bongaerts, Johannes and Sprenger, G. and Takors, Ralf}, title = {Process control for enhanced L-phenylalanine production using different recombinant Escherichia coli strains}, series = {Biotechnology and bioengineering}, volume = {Vol. 80}, journal = {Biotechnology and bioengineering}, number = {Iss. 7}, issn = {1097-0290 (E-Journal); 0006-3592 (Print)}, pages = {746 -- 754}, year = {2002}, language = {en} } @article{BiselliBornWandrey1995, author = {Biselli, Manfred and Born, C. and Wandrey, C.}, title = {Production of monoclonal antibodies in a pilot scale fluidized bed bioreactor / Born, C.; Biselli, M.; Wandrey, C.}, series = {Animal cell technology : developments towards the 21st century / edited by E. C. Beuvery}, journal = {Animal cell technology : developments towards the 21st century / edited by E. C. Beuvery}, publisher = {Kluwer Acad. Press}, address = {Dordrecht}, isbn = {0-7923-3736-0}, pages = {515 -- 519}, year = {1995}, language = {en} } @article{PaulssenHoehrHouetal.2015, author = {Paulßen, Elisabeth and Hoehr, Cornelia and Hou, Xinchi and Hanemaayer, Victoire and Zeisler, Stefan and Adam, Michael J. and Ruth, Thomas J. and Celler, Anna and Buckley, Ken and Benard, Francois and Schaffer, Paul}, title = {Production of Y-86 and other radiometals for research purposes using a solution target system}, series = {Nuclear medicine and biology}, volume = {42}, journal = {Nuclear medicine and biology}, number = {11}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1872-9614}, doi = {10.1016/j.nucmedbio.2015.06.005}, pages = {842 -- 849}, year = {2015}, language = {en} } @article{SelmerAchebachUnden2005, author = {Selmer, Thorsten and Achebach, Stephanie and Unden, Gottfried}, title = {Properties and significance of apoFNR as a second form of air-inactivated [4Fe-4S]·FNR of Escherichia coli / Achebach, S. ; Selmer, T. ; Unden, G.}, series = {The FEBS Journal. 272 (2005), H. 16}, journal = {The FEBS Journal. 272 (2005), H. 16}, isbn = {1742-464X}, pages = {4260 -- 4269}, year = {2005}, language = {en} } @article{SelmerWillanzheimerHetzel2002, author = {Selmer, Thorsten and Willanzheimer, Angela and Hetzel, Marc}, title = {Propionate CoA-transferase from Clostridium propionicum. Cloning of the gene and identification of glutamate 324 at the active site}, series = {European Journal of Biochemistry. 269 (2002), H. 1}, journal = {European Journal of Biochemistry. 269 (2002), H. 1}, isbn = {0014-2956}, pages = {372 -- 380}, year = {2002}, language = {en} } @article{DellmannGloriusLitvinovetal.2023, author = {Dellmann, Sophia Florence and Glorius, J. and Litvinov, Yu A. and Reifarth, R. and Al-Khasawneh, Kafa and Aliotta, M. and Bott, L. and Br{\"u}ckner, Benjamin and Bruno, C. G. and Chen, Ruijiu and Davinson, T. and Dickel, T. and Dillmann, Iris and Dmytriev, D. and Erbacher, P. and Freire-Fern{\´a}ndez, D. and Forstner, Oliver and Geissel, H. and G{\"o}bel, K. and Griffin, Christopher J. and Grisenti, R. and Gumberidze, Alexandre and Haettner, Emma and Hagmann, Siegbert and Heil, M. and Heß, R. and Hillenbrand, P.-M. and Joseph, R. and Jurado, B. and Kozhuharov, Christophor and Kulikov, I. and L{\"o}her, Bastian and Langer, Christoph and Leckenby, Guy and Lederer-Woods, C. and Lestinsky, M. and Litvinov, S. A. and Lorenz, B. A. and Lorenz, E. and Marsh, J. and Menz, Esther Babette and Morgenroth, T. and Petridis, N. and Pibernat, Jerome and Popp, U. and Psaltis, Athanasios and Sanjari, Shahab and Scheidenberger, C. and Sguazzin, M. and Sidhu, Ragandeep Singh and Spillmann, Uwe and Steck, M. and St{\"o}hlker, T. and Surzhykov, A. and Swartz, J. A. and T{\"o}rnqvist, H. and Varga, L. and Vescovi, Diego and Weick, H. and Weigand, M. and Woods, P. and Xing, Y. and Yamaguchi, Taiyo}, title = {Proton capture on stored radioactive ¹¹⁸Te ions}, series = {EPJ Web of Conferences}, volume = {279}, journal = {EPJ Web of Conferences}, number = {Article Number: 11018}, publisher = {EDP Sciences}, issn = {2100-014X}, doi = {10.1051/epjconf/202327911018}, pages = {1 -- 5}, year = {2023}, abstract = {Experimental determination of the cross sections of proton capture on radioactive nuclei is extremely difficult. Therefore, it is of substantial interest for the understanding of the production of the p-nuclei. For the first time, a direct measurement of proton-capture cross sections on stored, radioactive ions became possible in an energy range of interest for nuclear astrophysics. The experiment was performed at the Experimental Storage Ring (ESR) at GSI by making use of a sensitive method to measure (p,γ) and (p,n) reactions in inverse kinematics. These reaction channels are of high relevance for the nucleosyn-thesis processes in supernovae, which are among the most violent explosions in the universe and are not yet well understood. The cross section of the ¹¹⁸Te(p,γ) reaction has been measured at energies of 6 MeV/u and 7 MeV/u. The heavy ions interacted with a hydrogen gas jet target. The radiative recombination process of the fully stripped ¹¹⁸Te ions and electrons from the hydrogen target was used as a luminosity monitor. An overview of the experimental method and preliminary results from the ongoing analysis will be presented.}, language = {en} } @article{UlberPothMonzonetal.2010, author = {Ulber, Roland and Poth, Sebastian and Monzon, Magaly and Tippk{\"o}tter, Nils}, title = {Prozessintegration von Hydrolyse und Fermentation von Cellulose- Faserstoff}, series = {Chemie Ingenieur Technik}, volume = {82}, journal = {Chemie Ingenieur Technik}, number = {1-2}, issn = {1522-2640}, doi = {10.1002/cite.200900103}, pages = {135 -- 139}, year = {2010}, abstract = {Ein viel versprechender erneuerbarer Rohstoff f{\"u}r die Produktion von Chemikalien und Treibstoffen ist Lignocellulose aus pflanzlicher Biomasse. Die darin enthaltenen Zucker k{\"o}nnen mittels enzymatischer Hydrolyse freigesetzt und fermentativ zu Ethanol umgesetzt werden. Ein interessanter Ansatz ist dabei die simultane Verzuckerung und Fermentation. Hefen und Enzyme haben mit 30 °C bzw. 50 °C zwar unterschiedliche Temperaturoptima, es konnte aber gezeigt werden, dass auch bei den niedrigeren Temperaturen eine Umsetzung der Cellulose zu Glucose erfolgt, wenn auch langsamer als bei optimalen Bedingungen. Außerdem konnte in Vorversuchen gezeigt werden, dass Ethanol in den zu erwartenden Konzentrationen keinen Einfluss auf die enzymatische Umsetzung hat.}, language = {de} } @article{SchmitzHirschBongaertsetal.2002, author = {Schmitz, M. and Hirsch, E. and Bongaerts, Johannes and Takors, Ralf}, title = {Pulse experiments as a prerequisite for the quantification of in vivo enzyme kinetics in aromatic amino acid pathway of Eschericia coli}, series = {Biotechnology progress}, volume = {Vol. 18}, journal = {Biotechnology progress}, number = {Iss. 5}, issn = {1520-6033 (E-Journal); 8756-7938 (Print)}, pages = {935 -- 941}, year = {2002}, language = {en} } @article{BiselliThoemmesBornetal.1995, author = {Biselli, Manfred and Th{\"o}mmes, J. and Born, C. and Wandrey, C.}, title = {Purification of monoclonal antibodies by fluidized bed adsorption / Th{\"o}mmes, J. ; Born, C. Biselli, M. ; Wandrey, C. ; Kula, M.-R.}, series = {Animal cell technology : developments towards the 21st century / edited by E. C. Beuvery}, journal = {Animal cell technology : developments towards the 21st century / edited by E. C. Beuvery}, publisher = {Kluwer Acad. Press}, address = {Dordrecht}, isbn = {0-7923-3736-0}, pages = {515 -- 519}, year = {1995}, language = {en} } @article{TippkoetterRoth2020, author = {Tippk{\"o}tter, Nils and Roth, Jasmine}, title = {Purified Butanol from Lignocellulose - Solvent-Impregnated Resins for an Integrated Selective Removal}, series = {Chemie Ingenieur Technik}, volume = {92}, journal = {Chemie Ingenieur Technik}, number = {11}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1522-2640}, doi = {10.1002/cite.202000200}, pages = {1741 -- 1751}, year = {2020}, abstract = {In traditional microbial biobutanol production, the solvent must be recovered during fermentation process for a sufficient space-time yield. Thermal separation is not feasible due to the boiling point of n-butanol. As an integrated and selective solid-liquid separation alternative, solvent impregnated resins (SIRs) were applied. Two polymeric resins were evaluated and an extractant screening was conducted. Vacuum application with vapor collection in fixed-bed column as bioreactor bypass was successfully implemented as butanol desorption step. In course of further increasing process economics, fermentation with renewable lignocellulosic substrates was conducted using Clostridium acetobutylicum. Utilization of SIR was shown to be a potential strategy for solvent removal from fermentation broth, while application of a bypass column allows for product removal and recovery at once.}, language = {en} }