@article{KirchnerReisertPuetzetal.2012, author = {Kirchner, Patrick and Reisert, Steffen and P{\"u}tz, Patrick and Keusgen, Michael and Sch{\"o}ning, Michael Josef}, title = {Characterisation of polymeric materials as passivation layer for calorimetric H2O2 gas sensors}, series = {Physica Status Solidi (a)}, volume = {209}, journal = {Physica Status Solidi (a)}, number = {5}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1862-6319}, doi = {10.1002/pssa.201100773}, pages = {859 -- 863}, year = {2012}, abstract = {Calorimetric gas sensors for monitoring the H₂O₂ concentration at elevated temperatures in industrial sterilisation processes have been presented in previous works. These sensors are built up in form of a differential set-up of a catalytically active and passive temperature-sensitive structure. Although, various types of catalytically active dispersions have been studied, the passivation layer has to be established and therefore, chemically as well as physically characterised. In the present work, fluorinated ethylene propylene (FEP), perfluoralkoxy (PFA) and epoxy-based SU-8 photoresist as temperature-stable polymeric materials have been investigated for sensor passivation in terms of their chemical inertness against H₂O₂, their hygroscopic properties as well as their morphology. The polymeric materials were deposited via spin-coating on the temperature-sensitive structure, wherein spin-coated FEP and PFA show slight agglomerates. However, they possess a low absorption of humidity due to their hydrophobic surface, whereas the SU-8 layer has a closed surface but shows a slightly higher absorption of water. All of them were inert against gaseous H₂O₂ during the characterisation in H₂O₂ atmosphere that demonstrates their suitability as passivation layer for calorimetric H₂O₂ gas sensors.}, language = {en} } @inproceedings{OertelBung2012, author = {Oertel, Mario and Bung, Daniel B.}, title = {Characteristics of cross-bar block ramp flows}, series = {Hydraulic structures into the 21st century : 4th IAHR International Symposium on Hydraulic Structures : 9.-11.2.2012, Porto}, booktitle = {Hydraulic structures into the 21st century : 4th IAHR International Symposium on Hydraulic Structures : 9.-11.2.2012, Porto}, organization = {International Symposium on Hydraulic Structures <4, 2012, Porto>}, isbn = {978-989-8509-01-7}, pages = {Elektronisch publiziert}, year = {2012}, language = {en} } @article{SchusserPoghossianBaeckeretal.2012, author = {Schusser, Sebastian and Poghossian, Arshak and B{\"a}cker, Matthias and Leinhos, Marcel and Wagner, Patrick and Sch{\"o}ning, Michael Josef}, title = {Characterization of biodegradable polymers with capacitive field-effect sensors}, series = {Sensors and actuators B: Chemical}, volume = {187}, journal = {Sensors and actuators B: Chemical}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0925-4005}, doi = {10.1016/j.snb.2012.07.099}, pages = {2 -- 7}, year = {2012}, abstract = {In vitro studies of the degradation kinetic of biopolymers are essential for the design and optimization of implantable biomedical devices. In the presented work, a field-effect capacitive sensor has been applied for the real-time and in situ monitoring of degradation processes of biopolymers for the first time. The polymer-covered field-effect sensor is, in principle, capable to detect any changes in bulk, surface and interface properties of the polymer induced by degradation processes. The feasibility of this approach has been experimentally proven by using the commercially available biomedical polymer poly(D,L-lactic acid) (PDLLA) as a model system. PDLLA films of different thicknesses were deposited on the Ta₂O₅-gate surface of the field-effect structure from a polymer solution by means of spin-coating method. The polymer-modified field-effect sensors have been characterized by means of capacitance-voltage and impedance-spectroscopy method. The degradation of the PDLLA was accelerated by changing the degradation medium from neutral (pH 7.2) to alkaline (pH 9) condition, resulting in drastic changes in the capacitance and impedance spectra of the polymer-modified field-effect sensor.}, language = {en} } @article{MiyamotoIchimuraWagneretal.2012, author = {Miyamoto, K. and Ichimura, H. and Wagner, Torsten and Yoshinobu, T. and Sch{\"o}ning, Michael Josef}, title = {Chemical Imaging of ion Diffusion in a Microfluidic Channel}, series = {Procedia Engineering}, journal = {Procedia Engineering}, number = {47}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1877-7058}, doi = {10.1016/j.proeng.2012.09.289}, pages = {886 -- 889}, year = {2012}, abstract = {The chemical imaging sensor is a chemical sensor which is capable of visualizing the spatial distribution of chemical species in sample solution. In this study, a novel measurement system based on the chemical imaging sensor was developed to observe the inside of a Y-shaped microfluidic channel while injecting two sample solutions from two branches. From the collected chemical images, it was clearly observed that the injected solutions formed laminar flows in the microfluidic channel. In addition, ion diffusion across the laminar flows was observed. This label-free method can acquire quantitative data of ion distribution and diffusion in microfluidic devices, which can be used to determine the diffusion coefficients, and therefore, the molecular weights of chemical species in the sample solution.}, language = {en} } @article{SchoeningBaecker2012, author = {Sch{\"o}ning, Michael Josef and B{\"a}cker, Matthias}, title = {Chip-basierte Sensoren f{\"u}r die Biotechnik}, volume = {13}, number = {2}, publisher = {BIOCOM}, address = {Berlin}, issn = {1611-0854}, year = {2012}, language = {de} } @article{HuckPoghossianWagneretal.2012, author = {Huck, Christina and Poghossian, Arshak and Wagner, Patrick and Sch{\"o}ning, Michael Josef}, title = {Combined amperometric/field-effect sensor for the detection of dissolved hydrogen}, series = {Sensors and actuators B: Chemical}, volume = {187}, journal = {Sensors and actuators B: Chemical}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0925-4005}, doi = {10.1016/j.snb.2012.10.050}, pages = {168 -- 173}, year = {2012}, abstract = {Real-time and reliable monitoring of the biogas process is crucial for a stable and efficient operation of biogas production in order to avoid digester breakdowns. The concentration of dissolved hydrogen (H₂) represents one of the key parameters for biogas process control. In this work, a one-chip integrated combined amperometric/field-effect sensor for monitoring the dissolved H₂ concentration has been developed for biogas applications. The combination of two different transducer principles might allow a more accurate and reliable measurement of dissolved H₂ as an early warning indicator of digester failures. The feasibility of the approach has been demonstrated by simultaneous amperometric/field-effect measurements of dissolved H₂ concentrations in electrolyte solutions. Both, the amperometric and the field-effect transducer show a linear response behaviour in the H₂ concentration range from 0.1 to 3\% (v/v) with a slope of 198.4 ± 13.7 nA/\% (v/v) and 14.9 ± 0.5 mV/\% (v/v), respectively.}, language = {en} } @inproceedings{TakenagaWernerSawadaetal.2012, author = {Takenaga, Shoko and Werner, Frederik and Sawada, Kazuaki and Sch{\"o}ning, Michael Josef}, title = {Comparison of label-free ACh image sensors based on CCD and LAPS}, isbn = {978-3-9813484-2-2}, doi = {10.5162/IMCS2012/4.2.6}, pages = {356 -- 359}, year = {2012}, language = {en} } @incollection{HoffschmidtAlexopoulosRauetal.2012, author = {Hoffschmidt, Bernhard and Alexopoulos, Spiros and Rau, Christoph and Sattler, Johannes, Christoph and Anthrakidis, Anette and Teixeira Boura, Cristiano Jos{\´e} and O'Connor, P. and Hilger, Patrick}, title = {Concentrating solar power}, series = {Comprehensive renewable energy / ed. Ali Sayigh. Vol. 3: Solar thermal systems: components and applications}, volume = {3}, booktitle = {Comprehensive renewable energy / ed. Ali Sayigh. Vol. 3: Solar thermal systems: components and applications}, publisher = {Elsevier}, address = {Amsterdam}, isbn = {978-0-08-087872-0}, doi = {10.1016/B978-0-08-087872-0.00319-X}, pages = {595 -- 636}, year = {2012}, language = {en} } @inproceedings{KoetterDeckerDetzleretal.2012, author = {K{\"o}tter, Jens and Decker, Stefan and Detzler, Raphael and Sch{\"a}fer, Jochen and Schmitz, Mark and Herrmann, Ulf}, title = {Cost Reduction of Solar Fields with HelioTrough Collector}, publisher = {FLAGSOL}, address = {K{\"o}ln}, pages = {9 S. : Ill., graph. Darst.}, year = {2012}, language = {en} } @inproceedings{FissabreSchmidtSonnleitner2012, author = {Fissabre, Anke and Schmidt, Klaus and Sonnleitner, Andrea}, title = {Das Lehnsm{\"u}hlschloß in Ortrand - ein s{\"a}chsisches Herrenhaus der Renaissance}, series = {Wandel im Wohnbau zwischen Gotik und Barock : die s{\"a}chsisch-b{\"o}hmische Entwicklung im {\"u}berregionalen Vergleich}, booktitle = {Wandel im Wohnbau zwischen Gotik und Barock : die s{\"a}chsisch-b{\"o}hmische Entwicklung im {\"u}berregionalen Vergleich}, publisher = {Jonas}, address = {Marburg}, isbn = {978-3-89445-390-9}, pages = {487 -- 501}, year = {2012}, language = {de} } @inproceedings{BeckerEggertFleischeretal.2012, author = {Becker, J{\"o}rg and Eggert, Mathias and Fleischer, Stefan and Heddier, Marcel and Knackstedt, Ralf}, title = {Data Warehouse Design and Legal Visualization - The Applicability of H2 for Reporting}, series = {Proceedings of the 23rd Australasian Conference on Information Systems 2012}, booktitle = {Proceedings of the 23rd Australasian Conference on Information Systems 2012}, pages = {11 S.}, year = {2012}, language = {de} } @techreport{ButenwegDargelHoechstetal.2012, author = {Butenweg, Christoph and Dargel, H.-J. and H{\"o}chst, T. and Holtschoppen, B. and Schwarz, R. and Sippel, M.}, title = {Der Lastfall Erdbeben im Anlagenbau : Leitfaden : Entwurf, Bemessung und Konstruktion von Tragwerken und Komponenten in der chemischen Industrie in Anlehnung an die DIN EN 1998-1}, publisher = {Verband der Chemischen Industrie e.V.}, address = {Frankfurt}, pages = {20 S.}, year = {2012}, language = {de} } @article{ChludekTran2012, author = {Chludek, Astrid and Tran, Duc Hung}, title = {Der Reformvorschlag des IAS 12 gem. ED/2009/2 - Ein Pl{\"a}doyer f{\"u}r die Einf{\"u}hrung der valuation allowance}, series = {KoR Zeitschrift f{\"u}r kapitalmarktorientierte Rechnungslegung}, journal = {KoR Zeitschrift f{\"u}r kapitalmarktorientierte Rechnungslegung}, number = {1}, publisher = {Fachmedien Otto Schmidt}, address = {D{\"u}sseldorf}, issn = {1617-8084}, pages = {4 -- 8}, year = {2012}, language = {de} } @article{LeursMezoOehlschlaegeretal.2012, author = {Leurs, Ulrike and Mezo, Gabor and {\"O}hlschl{\"a}ger, Peter and Orban, Erika and Marquard, Andrea and Manea, Marilena}, title = {Design, synthesis, in vitro stability and cytostatic effect of multifunctional anticancer drug-bioconjugates containing GnRH-III as a targeting moiety}, series = {Peptide Science}, volume = {98}, journal = {Peptide Science}, number = {1}, publisher = {Wiley}, address = {New York, NY}, issn = {1097-0282}, doi = {10.1002/bip.21640}, pages = {1 -- 10}, year = {2012}, abstract = {Bioconjugates containing the GnRH-III hormone decapeptide as a targeting moiety are able to deliver chemotherapeutic agents specifically to cancer cells expressing GnRH receptors, thereby increasing their local efficacy while limiting the peripheral toxicity. However, the number of GnRH receptors on cancer cells is limited and they desensitize under continuous hormone treatment. A possible approach to increase the receptor mediated tumor targeting and consequently the cytostatic effect of the bioconjugates would be the attachment of more than one chemotherapeutic agent to one GnRH-III molecule. Here we report on the design, synthesis and biochemical characterization of multifunctional bioconjugates containing GnRH-III as a targeting moiety and daunorubicin as a chemotherapeutic agent. Two different drug design approaches were pursued. The first one was based on the bifunctional [4Lys]-GnRH-III (Glp-His-Trp-Lys-His-Asp-Trp-Lys-Pro-Gly-NH2) containing two lysine residues in positions 4 and 8, whose ϵ-amino groups were used for the coupling of daunorubicin. In the second drug design, the native GnRH-III (Glp-His-Trp-Ser-His-Asp-Trp-Lys-Pro-Gly-NH2) was used as a scaffold; an additional lysine residue was coupled to the ϵ-amino group of 8Lys in order to generate two free amino groups available for conjugation of daunorubicin. The in vitro stability/degradation of all synthesized compounds was investigated in human serum, as well as in the presence of rat liver lysosomal homogenate. Their cellular uptake was determined on human breast cancer cells and the cytostatic effect was evaluated on human breast, colon and prostate cancer cell lines. Compared with a monofunctional compound, both drug design approaches resulted in multifunctional bioconjugates with increased cytostatic effect.}, language = {en} } @article{KernSchelthoffMathieu2012, author = {Kern, Alexander and Schelthoff, Christof and Mathieu, Moritz}, title = {Detaillierte Berechnung der Einfangwirksamkeiten von Fangeinrichtungen}, series = {Elektro-Praktiker}, volume = {66}, journal = {Elektro-Praktiker}, number = {4}, publisher = {Huss Medien}, address = {Berlin}, issn = {0013-5569}, pages = {6 Seiten}, year = {2012}, abstract = {Im Beitrag wird zun{\"a}chst das Verfahren eines dynamischen elektro-geometrischen Modells vorgestellt. Dieses arbeitet im Gegensatz zum klassischen Blitzkugel-Verfahren nicht mit konstanten Radien; vielmehr wird der Radius der Blitzkugel variiert. Dabei werden ausschließlich vorhandene und in internationalen Normen anerkannte Ergebnisse, blitzphysikalische Grundlagen und Untersuchungen verwendet, und auf deren Grundlage ein numerisches Verfahren erarbeitet. Mit dem dynamischen elektro-geometrischen Modell werden dann einige Beispiele des Schutzes mit Fangstangen, die gem{\"a}ß dem klassischen Blitzkugel-Verfahren nach DIN EN 62305-3 f{\"u}r die Schutzklassen I - II - III - IV geplant sind, untersucht. Es wird gezeigt, dass die Einfangwirksamkeiten wesentlich h{\"o}her sind als in der Normenreihe DIN EN 62305 selbst angegeben. Grund daf{\"u}r ist die Tatsache, dass das Blitzkugel-Verfahren sehr konservativ aufgebaut ist und dem Planer von Blitzschutzsystemen nur die m{\"o}glichen Stellen f{\"u}r einen Einschlag aufzeigt, ohne eine Bewertung der Einschlagsh{\"a}ufigkeit zu liefern. Andererseits bedeutet dies jedoch, dass man mit dem klassischen Blitzkugel-Verfahren stets auf der „sicheren Seite" liegt.}, language = {de} } @inproceedings{BohrnMuchaWerneretal.2012, author = {Bohrn, Ulrich and Mucha, Andreas and Werner, Frederik and St{\"u}tz, Evamaria and B{\"a}cker, Matthias and Krumbe, Christoph and Schienle, Meinrad and Fleischer, Maximilian and Wagner, Patrick and Sch{\"o}ning, Michael Josef}, title = {Detection of toxic chromium species in water using cellbased sensor systems}, isbn = {978-3-9813484-2-2}, doi = {10.5162/IMCS2012/P2.1.14}, pages = {1364 -- 1367}, year = {2012}, language = {en} } @inproceedings{HartmannKallweitFeldusenetal.2012, author = {Hartmann, Axel and Kallweit, Stephan and Feldusen, Antje and Schr{\"o}der, Wolfgang}, title = {Detection of upstream propagating sound waves at buffet flow using high-speed PIV}, pages = {14 S. : graph. Darst.}, year = {2012}, language = {en} } @book{Gell2012, author = {Gell, Sebastian}, title = {Determinants of earnings forecast error, earnings forecast revision and earnings forecast accuracy}, publisher = {Springer Gabler}, address = {Wiesbaden}, isbn = {978-3-8349-3936-4}, doi = {10.1007/978-3-8349-3937-1}, pages = {XXIV, 125 Seiten}, year = {2012}, abstract = {​Earnings forecasts are ubiquitous in today's financial markets. They are essential indicators of future firm performance and a starting point for firm valuation. Extremely inaccurate and overoptimistic forecasts during the most recent financial crisis have raised serious doubts regarding the reliability of such forecasts. This thesis therefore investigates new determinants of forecast errors and accuracy. In addition, new determinants of forecast revisions are examined. More specifically, the thesis answers the following questions: 1) How do analyst incentives lead to forecast errors? 2) How do changes in analyst incentives lead to forecast revisions?, and 3) What factors drive differences in forecast accuracy?}, language = {en} } @article{HasanKeilStaatetal.2012, author = {Hasan, Istabrak and Keil, Ludger and Staat, Manfred and Wahl, Gerhard and Bourauel, Christoph}, title = {Determination of the frictional coefficient of the implant-antler interface : experimental approach}, series = {Biomedical Engineering / Biomedizinische Technik}, volume = {57}, journal = {Biomedical Engineering / Biomedizinische Technik}, number = {5}, publisher = {De Gruyter}, address = {Berlin}, issn = {1862-278X}, pages = {359 -- 363}, year = {2012}, abstract = {The similar bone structure of reindeer antler to human bone permits studying the osseointegration of dental implants in the jawbone. As the friction is one of the major factors that have a significant influence on the initial stability of immediately loaded dental implants, it is essential to define the frictional coefficient of the implant-antler interface. In this study, the kinetic frictional forces at the implant-antler interface were measured experimentally using an optomechanical setup and a stepping motor controller under different axial loads and sliding velocities. The corresponding mean values of the static and kinetic frictional coefficients were within the range of 0.5-0.7 and 0.3-0.5, respectively. An increase in the frictional forces with increasing applied axial loads was registered. The measurements showed an evidence of a decrease in the magnitude of the frictional coefficient with increasing sliding velocity. The results of this study provide a considerable assessment to clarify the suitable frictional coefficient to be used in the finite element contact analysis of antler specimens.}, language = {en} } @article{WagnerWernerMiyamotoetal.2012, author = {Wagner, Torsten and Werner, Frederik and Miyamoto, Ko-Ichiro and Sch{\"o}ning, Michael Josef and Yoshinobu, Tatsuo}, title = {Development and characterisation of a compact light-addressable potentiometric sensor (LAPS) based on the digital light processing (DLP) technology for flexible chemical imaging}, series = {Sensors and Actuators B: Chemical}, volume = {170}, journal = {Sensors and Actuators B: Chemical}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0925-4005}, doi = {10.1016/j.snb.2010.12.003}, pages = {34 -- 39}, year = {2012}, abstract = {Chemical imaging systems allow the visualisation of the distribution of chemical species on the sensor surface. This work represents a new flexible approach to read out light-addressable potentiometric sensors (LAPS) with the help of a digital light processing (DLP) set-up. The DLP, known well for video projectors, consists of a mirror-array MEMS device, which allows fast and flexible generation of light patterns. With the help of these light patterns, the sensor surface of the LAPS device can be addressed. The DLP approach has several advantages compared to conventional LAPS set-ups, e.g., the spot size and the shape of the light pointer can be changed easily and no mechanical movement is necessary, which reduces the size of the set-up and increases the stability and speed of the measurement. In addition, the modulation frequency and intensity of the light beam are important parameters of the LAPS set-up. Within this work, the authors will discuss two different ways of light modulation by the DLP set-up, investigate the influence of different modulation frequencies and different light intensities as well as demonstrate the scanning capabilities of the new set-up by pH mapping on the sensor surface.}, language = {en} }