@article{UysalFiratCreutzetal.2022,
  author    = {Uysal, Karya and Firat, Ipek Serat and Creutz, Till and Aydin, Inci Cansu and Artmann, Gerhard and Teusch, Nicole and Temiz Artmann, Ayseg{\"u}l},
  title     = {A novel in vitro wound healing assay using free-standing, ultra-thin PDMS membranes},
  series = {membranes},
  volume    = {2023},
  journal   = {membranes},
  number    = {13(1)},
  publisher = {MDPI},
  address   = {Basel},
  doi       = {10.3390/membranes13010022},
  pages     = {Artikel 22},
  year      = {2022},
  abstract  = {Advances in polymer science have significantly increased polymer applications in life sciences. We report the use of free-standing, ultra-thin polydimethylsiloxane (PDMS) membranes, called CellDrum, as cell culture substrates for an in vitro wound model. Dermal fibroblast monolayers from 28- and 88-year-old donors were cultured on CellDrums. By using stainless steel balls, circular cell-free areas were created in the cell layer (wounding). Sinusoidal strain of 1 Hz, 5\% strain, was applied to membranes for 30 min in 4 sessions. The gap circumference and closure rate of un-stretched samples (controls) and stretched samples were monitored over 4 days to investigate the effects of donor age and mechanical strain on wound closure. A significant decrease in gap circumference and an increase in gap closure rate were observed in trained samples from younger donors and control samples from older donors. In contrast, a significant decrease in gap closure rate and an increase in wound circumference were observed in the trained samples from older donors. Through these results, we propose the model of a cell monolayer on stretchable CellDrums as a practical tool for wound healing research. The combination of biomechanical cell loading in conjunction with analyses such as gene/protein expression seems promising beyond the scope published here.},
  language  = {en}
}
@article{TemizArtmannAkhisarogluSercanetal.2005,
  author    = {Temiz Artmann, Ayseg{\"u}l and Akhisaroglu, M. and Sercan, Z. and Kayatekin, B. M.},
  title     = {Adhesion of Erythrocytes to Endothelial Cells After Acute Exercise: Differences in Red Blood Cells from Juvenile and Adult Rats. Temiz Artmann, A.; Akhisaroglu, M.; Sercan, Z.; Kayatekin, BM.; Yorukoglu, K.; Kirkali, G.},
  series = {Physiological Research (2005)},
  journal   = {Physiological Research (2005)},
  isbn      = {0862-8408},
  year      = {2005},
  language  = {en}
}
@article{KozhalakovaZhubanovaMansurovetal.2010,
  author    = {Kozhalakova, A. A. and Zhubanova, Azhar A. and Mansurov, Z. A. and Digel, Ilya and Tazhibayeva, S. M. and Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l},
  title     = {Adsorption of bacterial lipopolysaccharides on carbonized rice shell},
  series = {Science of Central Asia (2010)},
  journal   = {Science of Central Asia (2010)},
  pages     = {50 -- 54},
  year      = {2010},
  language  = {en}
}
@article{NiedermeyerZhouDursunetal.2016,
  author    = {Niedermeyer, Angela and Zhou, Bei and Dursun, G{\"o}zde and Temiz Artmann, Ayseg{\"u}l and Markert, Bernd},
  title     = {An examination of tissue engineered scaffolds in a bioreactor},
  series = {Proceedings in Applied Mathematics and Mechanics PAMM},
  volume    = {16},
  journal   = {Proceedings in Applied Mathematics and Mechanics PAMM},
  number    = {1},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {1617-7061},
  doi       = {10.1002/pamm.201610038},
  pages     = {99 -- 100},
  year      = {2016},
  abstract  = {Replacement tissues, designed to fill in articular cartilage defects, should exhibit the same properties as the native material. The aim of this study is to foster the understanding of, firstly, the mechanical behavior of the material itself and, secondly, the influence of cultivation parameters on cell seeded implants as well as on cell migration into acellular implants. In this study, acellular cartilage replacement material is theoretically, numerically and experimentally investigated regarding its viscoelastic properties, where a phenomenological model for practical applications is developed. Furthermore, remodeling and cell migration are investigated.},
  language  = {en}
}
@article{DigelTemizArtmannNishikawaetal.2005,
  author    = {Digel, Ilya and Temiz Artmann, Ayseg{\"u}l and Nishikawa, K. and Cook, M.},
  title     = {Bactericidal effects of plasma-generated cluster ions},
  series = {Medical and Biological Engineering and Computing. 43 (2005), H. 6},
  journal   = {Medical and Biological Engineering and Computing. 43 (2005), H. 6},
  isbn      = {1741-0444},
  pages     = {800 -- 807},
  year      = {2005},
  language  = {en}
}
@article{UysalCreutzFiratetal.2022,
  author    = {Uysal, Karya and Creutz, Till and Firat, Ipek Seda and Artmann, Gerhard and Teusch, Nicole and Temiz Artmann, Ayseg{\"u}l},
  title     = {Bio-functionalized ultra-thin, large-area and waterproof silicone membranes for biomechanical cellular loading and compliance experiments},
  series = {Polymers},
  volume    = {14},
  journal   = {Polymers},
  number    = {11},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2073-4360},
  pages     = {2213},
  year      = {2022},
  abstract  = {Biocompatibility, flexibility and durability make polydimethylsiloxane (PDMS) membranes top candidates in biomedical applications. CellDrum technology uses large area, <10 µm thin membranes as mechanical stress sensors of thin cell layers. For this to be successful, the properties (thickness, temperature, dust, wrinkles, etc.) must be precisely controlled. The following parameters of membrane fabrication by means of the Floating-on-Water (FoW) method were investigated: (1) PDMS volume, (2) ambient temperature, (3) membrane deflection and (4) membrane mechanical compliance. Significant differences were found between all PDMS volumes and thicknesses tested (p < 0.01). They also differed from the calculated values. At room temperatures between 22 and 26 °C, significant differences in average thickness values were found, as well as a continuous decrease in thicknesses within a 4 °C temperature elevation. No correlation was found between the membrane thickness groups (between 3-4 µm) in terms of deflection and compliance. We successfully present a fabrication method for thin bio-functionalized membranes in conjunction with a four-step quality management system. The results highlight the importance of tight regulation of production parameters through quality control. The use of membranes described here could also become the basis for material testing on thin, viscous layers such as polymers, dyes and adhesives, which goes far beyond biological applications.},
  language  = {en}
}
@book{ArtmannTemizArtmannZhubanovaetal.2018,
  author    = {Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l and Zhubanova, Azhar A. and Digel, Ilya},
  title     = {Biological, physical and technical basics of cell engineering},
  editor    = {Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l and Zhubanova, Azhar A. and Digel, Ilya},
  publisher = {Springer},
  address   = {Singapore},
  isbn      = {978-981-10-7903-0},
  pages     = {xxiv, 481 Seiten ; Illustrationen, Diagramme},
  year      = {2018},
  language  = {en}
}
@article{TemizArtmannYalcinResmietal.2002,
  author    = {Temiz Artmann, Ayseg{\"u}l and Yalcin, Ozlem and Resmi, Halil and Baskurt, Oguz K.},
  title     = {Can white blood cell activation be one of the major factors that affect hemorheological parameters during and after exercise?},
  series = {Clinical Hemorheology and Microcirculation. 26 (2002), H. 3},
  journal   = {Clinical Hemorheology and Microcirculation. 26 (2002), H. 3},
  isbn      = {1386-0291},
  pages     = {189 -- 193},
  year      = {2002},
  language  = {en}
}
@incollection{DigelSadykovTemizArtmannetal.2015,
  author    = {Digel, Ilya and Sadykov, R. and Temiz Artmann, Ayseg{\"u}l and Artmann, Gerhard},
  title     = {Changes in intestinal microflora in rats induced by oral exposure to low lead (II) concentrations},
  series = {Lead Exposure and Poisoning: Clinical Symptoms, Medical Management and Preventive Strategies},
  booktitle = {Lead Exposure and Poisoning: Clinical Symptoms, Medical Management and Preventive Strategies},
  publisher = {Nova Science Publ.},
  isbn      = {9781634826990},
  pages     = {75 -- 99},
  year      = {2015},
  language  = {en}
}
@article{ArtmannBurnsCanavesetal.2004,
  author    = {Artmann, Gerhard and Burns, Laura and Canaves, Jaume M. and Temiz Artmann, Ayseg{\"u}l},
  title     = {Circular dichroism spectra of human hemoglobin reveal a reversible structural transition at body temperature},
  series = {European Biophysics Journal. 33 (2004), H. 6},
  journal   = {European Biophysics Journal. 33 (2004), H. 6},
  isbn      = {1432-1017},
  pages     = {490 -- 496},
  year      = {2004},
  language  = {en}
}
@article{DigelTemizArtmannNishikawaetal.2004,
  author    = {Digel, Ilya and Temiz Artmann, Ayseg{\"u}l and Nishikawa, K. and Artmann, Gerhard},
  title     = {Cluster air-ion effects on bacteria and moulds},
  series = {Biomedizinische Technik. 49 (2004), H. Erg.-Bd. 2},
  journal   = {Biomedizinische Technik. 49 (2004), H. Erg.-Bd. 2},
  isbn      = {0932-4666},
  pages     = {1040 -- 1041},
  year      = {2004},
  language  = {en}
}
@article{KurzLinderTrzewiketal.2010,
  author    = {Kurz, R. and Linder, Peter and Trzewik, J{\"u}rgen and R{\"u}ffer, M. and Artmann, Gerhard and Digel, Ilya and Rothermel, A. and Robitzki, A. and Temiz Artmann, Ayseg{\"u}l},
  title     = {Contractile tension and beating rates of self-exciting monolayers and 3D-tissue constructs of neonatal rat cardiomyocytes},
  series = {Medical and Biological Engineering and Computing},
  volume    = {48},
  journal   = {Medical and Biological Engineering and Computing},
  number    = {1},
  publisher = {Springer Nature},
  address   = {Cham},
  issn      = {1741-0444},
  doi       = {10.1007/s11517-009-0552-y},
  pages     = {59 -- 65},
  year      = {2010},
  abstract  = {The CellDrum technology (The term 'CellDrum technology' includes a couple of slightly different technological setups for measuring lateral mechanical tension in various types of cell monolayers or 3D-tissue constructs) was designed to quantify the contraction rate and mechanical tension of self-exciting cardiac myocytes. Cells were grown either within flexible, circular collagen gels or as monolayer on top of respective 1-mum thin silicone membranes. Membrane and cells were bulged outwards by air pressure. This biaxial strain distribution is rather similar the beating, blood-filled heart. The setup allowed presetting the mechanical residual stress level externally by adjusting the centre deflection, thus, mimicking hypertension in vitro. Tension was measured as oscillating differential pressure change between chamber and environment. A 0.5-mm thick collagen-cardiac myocyte tissue construct induced after 2 days of culturing (initial cell density 2 x 10(4) cells/ml), a mechanical tension of 1.62 +/- 0.17 microN/mm(2). Mechanical load is an important growth regulator in the developing heart, and the orientation and alignment of cardiomyocytes is stress sensitive. Therefore, it was necessary to develop the CellDrum technology with its biaxial stress-strain distribution and defined mechanical boundary conditions. Cells were exposed to strain in two directions, radially and circumferentially, which is similar to biaxial loading in real heart tissues. Thus, from a biomechanical point of view, the system is preferable to previous setups based on uniaxial stretching.},
  language  = {en}
}
@article{KurulganDemirciLinderDemircietal.2009,
  author    = {Kurulgan Demirci, Eylem and Linder, Peter and Demirci, Taylan and Trzewik, J{\"u}rgen and Digel, Ilya and Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l},
  title     = {Contractile tension of endothelial cells: An LPS based in-vitro sepsis model},
  series = {IUBMB Life. 61 (2009), H. 3},
  journal   = {IUBMB Life. 61 (2009), H. 3},
  publisher = {Wiley},
  address   = {Weinheim},
  isbn      = {1521-6543},
  pages     = {307 -- 308},
  year      = {2009},
  language  = {en}
}
@article{MalikAbdievaUalievaetal.2019,
  author    = {Malik, A. M. and Abdieva, G. Zh. and Ualieva, P. S. and Zhubanova, A. A. and Temiz Artmann, Ayseg{\"u}l},
  title     = {CКPИНИНГ МИКPOOPГAНИЗМOВ-ДECТPУКТOPOВ XЛOРOPГAНИЧECКИX ЗAГPЯЗНИТEЛEЙ},
  series = {Eurasian Journal of Ecology},
  volume    = {61},
  journal   = {Eurasian Journal of Ecology},
  number    = {4},
  issn      = {2617-7358},
  pages     = {61 -- 71},
  year      = {2019},
  language  = {ru}
}
@article{SeifarthGossmannGrosseetal.2015,
  author    = {Seifarth, Volker and Goßmann, Matthias and Grosse, J. O. and Becker, C. and Heschel, I. and Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l},
  title     = {Development of a Bioreactor to Culture Tissue Engineered Ureters Based on the Application of Tubular OPTIMAIX 3D Scaffolds},
  series = {Urologia Internationalis},
  volume    = {2015},
  journal   = {Urologia Internationalis},
  number    = {95},
  publisher = {Karger},
  address   = {Basel},
  issn      = {0042-1138},
  doi       = {10.1159/000368419},
  pages     = {106 -- 113},
  year      = {2015},
  language  = {en}
}
@article{TemizArtmannKayatekinUysaletal.2005,
  author    = {Temiz Artmann, Ayseg{\"u}l and Kayatekin, Muammer B. and Uysal, N. and Resmi, H.},
  title     = {Does antioxidant supplementation alter the effects of acute exercise on erythrocyte aggregation, deformability and endothelium adhesion in untrained rats? Kayatekin, Muammer B.; Uysal N.; Resmi, H.; Bediz, Seref C.; Temiz Artmann, A.; Gen{\c{c}}, S.; Tugyan, K.},
  series = {International Journal for Vitamin and Nutrition Research. 75 (2005), H. 4},
  journal   = {International Journal for Vitamin and Nutrition Research. 75 (2005), H. 4},
  isbn      = {0300-9831},
  pages     = {243 -- 250},
  year      = {2005},
  language  = {en}
}
@article{CehreliAkpinarTemizArtmannetal.2015,
  author    = {Cehreli, Ruksan and Akpinar, Hale and Temiz Artmann, Ayseg{\"u}l and Sagol, Ozgul},
  title     = {Effects of Glutamine and Omega-3 Fatty Acids on Erythrocyte Deformability and Oxidative Damage in Rat Model of Enterocolitis},
  series = {Gastroenterology Research},
  volume    = {8},
  journal   = {Gastroenterology Research},
  number    = {5},
  issn      = {1918-2813},
  doi       = {10.14740/gr683w},
  pages     = {265 -- 273},
  year      = {2015},
  language  = {en}
}
@article{ErbayraktarYilmazTemizArtmannetal.2007,
  author    = {Erbayraktar, Zubeyde and Yilmaz, Osman and Temiz Artmann, Ayseg{\"u}l and Cehreli, Ruksan and Coker, Canan},
  title     = {Effects of Selenium Supplementation on Antioxidant Defense and Glucose Homeostasis in Experimental Diabetes Mellitus},
  series = {Biological Trace Element Research},
  volume    = {118},
  journal   = {Biological Trace Element Research},
  number    = {3},
  issn      = {1559-0720},
  pages     = {217 -- 226},
  year      = {2007},
  language  = {en}
}
@article{BassamDigelHescheleretal.2013,
  author    = {Bassam, Rasha and Digel, Ilya and Hescheler, J{\"u}rgen and Temiz Artmann, Ayseg{\"u}l and Artmann, Gerhard},
  title     = {Effects of spermine NONOate and ATP on protein aggregation: light scattering evidences},
  series = {BMC Biophysics},
  journal   = {BMC Biophysics},
  publisher = {BioMed Central},
  address   = {London},
  isbn      = {2046-1682},
  url       = {http://nbn-resolving.de/10.1186/2046-1682-6-1},
  pages     = {1 -- 14},
  year      = {2013},
  language  = {en}
}
@article{BassamHeschelerTemizArtmannetal.2012,
  author    = {Bassam, Rasha and Hescheler, J{\"u}rgen and Temiz Artmann, Ayseg{\"u}l and Artmann, Gerhard and Digel, Ilya},
  title     = {Effects of spermine NONOate and ATP on the thermal stability of hemoglobin},
  series = {BMC Biophysics},
  volume    = {5},
  journal   = {BMC Biophysics},
  publisher = {BioMed Central},
  address   = {London},
  issn      = {2046-1682},
  doi       = {10.1186/2046-1682-5-16},
  pages     = {Art. 16},
  year      = {2012},
  abstract  = {Background Minor changes in protein structure induced by small organic and inorganic molecules can result in significant metabolic effects. The effects can be even more profound if the molecular players are chemically active and present in the cell in considerable amounts. The aim of our study was to investigate effects of a nitric oxide donor (spermine NONOate), ATP and sodium/potassium environment on the dynamics of thermal unfolding of human hemoglobin (Hb). The effect of these molecules was examined by means of circular dichroism spectrometry (CD) in the temperature range between 25°C and 70°C. The alpha-helical content of buffered hemoglobin samples (0.1 mg/ml) was estimated via ellipticity change measurements at a heating rate of 1°C/min. Results Major results were: 1) spermine NONOate persistently decreased the hemoglobin unfolding temperature T u irrespectively of the Na + /K + environment, 2) ATP instead increased the unfolding temperature by 3°C in both sodium-based and potassium-based buffers and 3) mutual effects of ATP and NO were strongly influenced by particular buffer ionic compositions. Moreover, the presence of potassium facilitated a partial unfolding of alpha-helical structures even at room temperature. Conclusion The obtained data might shed more light on molecular mechanisms and biophysics involved in the regulation of protein activity by small solutes in the cell.},
  language  = {en}
}