@article{EngelmannSimsekShalabyetal.2024,
  author    = {Engelmann, Ulrich M. and Simsek, Beril and Shalaby, Ahmed and Krause, Hans-Joachim},
  title     = {Key contributors to signal generation in frequency mixing magnetic detection (FMMD): an in silico study},
  series = {Sensors},
  volume    = {24},
  journal   = {Sensors},
  number    = {6},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {1424-8220},
  doi       = {10.3390/s24061945},
  pages     = {Artikel 1945},
  year      = {2024},
  abstract  = {Frequency mixing magnetic detection (FMMD) is a sensitive and selective technique to detect magnetic nanoparticles (MNPs) serving as probes for binding biological targets. Its principle relies on the nonlinear magnetic relaxation dynamics of a particle ensemble interacting with a dual frequency external magnetic field. In order to increase its sensitivity, lower its limit of detection and overall improve its applicability in biosensing, matching combinations of external field parameters and internal particle properties are being sought to advance FMMD. In this study, we systematically probe the aforementioned interaction with coupled N{\´e}el-Brownian dynamic relaxation simulations to examine how key MNP properties as well as applied field parameters affect the frequency mixing signal generation. It is found that the core size of MNPs dominates their nonlinear magnetic response, with the strongest contributions from the largest particles. The drive field amplitude dominates the shape of the field-dependent response, whereas effective anisotropy and hydrodynamic size of the particles only weakly influence the signal generation in FMMD. For tailoring the MNP properties and parameters of the setup towards optimal FMMD signal generation, our findings suggest choosing large particles of core sizes dc > 25 nm nm with narrow size distributions (σ < 0.1) to minimize the required drive field amplitude. This allows potential improvements of FMMD as a stand-alone application, as well as advances in magnetic particle imaging, hyperthermia and magnetic immunoassays.},
  language  = {en}
}
@article{DachwaldUlamecPostbergetal.2020,
  author    = {Dachwald, Bernd and Ulamec, Stephan and Postberg, Frank and Sohl, Frank and Vera, Jean-Pierre de and Christoph, Waldmann and Lorenz, Ralph D. and Hellard, Hugo and Biele, Jens and Rettberg, Petra},
  title     = {Key technologies and instrumentation for subsurface exploration of ocean worlds},
  series = {Space Science Reviews},
  volume    = {216},
  journal   = {Space Science Reviews},
  number    = {Art. 83},
  publisher = {Springer},
  address   = {Dordrecht},
  issn      = {1572-9672},
  doi       = {10.1007/s11214-020-00707-5},
  pages     = {45},
  year      = {2020},
  abstract  = {In this chapter, the key technologies and the instrumentation required for the subsurface exploration of ocean worlds are discussed. The focus is laid on Jupiter's moon Europa and Saturn's moon Enceladus because they have the highest potential for such missions in the near future. The exploration of their oceans requires landing on the surface, penetrating the thick ice shell with an ice-penetrating probe, and probably diving with an underwater vehicle through dozens of kilometers of water to the ocean floor, to have the chance to find life, if it exists. Technologically, such missions are extremely challenging. The required key technologies include power generation, communications, pressure resistance, radiation hardness, corrosion protection, navigation, miniaturization, autonomy, and sterilization and cleaning. Simpler mission concepts involve impactors and penetrators or - in the case of Enceladus - plume-fly-through missions.},
  language  = {en}
}
@article{PietschmannRuhtz2001,
  author    = {Pietschmann, Bernd P. and Ruhtz, Vanessa},
  title     = {Knowledge Management},
  series = {Personal : Zeitschrift f{\"u}r Human Resource Management. 53 (2001), H. 5},
  journal   = {Personal : Zeitschrift f{\"u}r Human Resource Management. 53 (2001), H. 5},
  isbn      = {0031-5605},
  pages     = {242 -- 249},
  year      = {2001},
  language  = {en}
}
@article{GoedhuysJanzMohnen2014,
  author    = {Goedhuys, Micheline and Janz, Norbert and Mohnen, Pierre},
  title     = {Knowledge-based productivity in "low-tech" industries: evidence from firms in developing countries},
  series = {Industrial and corporate change},
  volume    = {23},
  journal   = {Industrial and corporate change},
  number    = {1},
  publisher = {Oxford University Press},
  address   = {Oxford},
  issn      = {1464-3650 (E-Journal); 0960-6491 (Print)},
  doi       = {10.1093/icc/dtt006},
  pages     = {1 -- 23},
  year      = {2014},
  abstract  = {Using firm-level data from five developing countries—Brazil, Ecuador, South Africa, Tanzania, and Bangladesh—and three industries—food processing, textiles, and the garments and leather products—this article examines the importance of various sources of knowledge for explaining productivity and formally tests whether sector- or country-specific characteristics dominate these relationships. Knowledge sources driving productivity appear mainly sector specific. Also differences in the level of development affect the effectiveness of knowledge sources. In the food processing sector, firms with higher educated managers are more productive, and in least-developed countries, additionally those with technology licenses and imported machinery and equipment. In the capital-intensive textiles sector, productivity is higher in firms that conduct R\&D. In the garments and leather products sector, higher education of the managers, licensing, and R\&D raise productivity.},
  language  = {en}
}
@article{HoylerCorminboeufJolie1997,
  author    = {Hoyler, Friedrich and Corminboeuf, F. and Jolie, J.},
  title     = {Kp=4+ double-gvibration in 164Dy / F. Corminboeuf ; J. Jolie ... F. Hoyler ...},
  series = {Physical review / C. 56 (1997), H. 3},
  journal   = {Physical review / C. 56 (1997), H. 3},
  isbn      = {0556-2813},
  pages     = {R1201},
  year      = {1997},
  language  = {en}
}
@article{SvaneborgKarimiVarzanehHojdisetal.2018,
  author    = {Svaneborg, Carsten and Karimi-Varzaneh, Hossein Ali and Hojdis, Nils and Fleck, Franz and Everaers, Ralf},
  title     = {Kremer-Grest Models for Universal Properties of Specific Common Polymer Species},
  series = {Soft Condensed Matter},
  journal   = {Soft Condensed Matter},
  number    = {1606.05008},
  year      = {2018},
  abstract  = {The Kremer-Grest (KG) bead-spring model is a near standard in Molecular Dynamic simulations of generic polymer properties. It owes its popularity to its computational efficiency, rather than its ability to represent specific polymer species and conditions. Here we investigate how to adapt the model to match the universal properties of a wide range of chemical polymers species. For this purpose we vary a single parameter originally introduced by Faller and M{\"u}ller-Plathe, the chain stiffness. Examples include polystyrene, polyethylene, polypropylene, cis-polyisoprene, polydimethylsiloxane, polyethyleneoxide and styrene-butadiene rubber. We do this by matching the number of Kuhn segments per chain and the number of Kuhn segments per cubic Kuhn volume for the polymer species and for the Kremer-Grest model. We also derive mapping relations for converting KG model units back to physical units, in particular we obtain the entanglement time for the KG model as function of stiffness allowing for a time mapping. To test these relations, we generate large equilibrated well entangled polymer melts, and measure the entanglement moduli using a static primitive-path analysis of the entangled melt structure as well as by simulations of step-strain deformation of the model melts. The obtained moduli for our model polymer melts are in good agreement with the experimentally expected moduli.},
  language  = {en}
}
@article{EveraersKarimiVarzanehFlecketal.2020,
  author    = {Everaers, Ralf and Karimi-Varzaneh, Hossein Ali and Fleck, Franz and Hojdis, Nils and Svaneborg, Carsten},
  title     = {Kremer-Grest Models for Commodity Polymer Melts: Linking Theory, Experiment, and Simulation at the Kuhn Scale},
  series = {Macromolecules},
  volume    = {53},
  journal   = {Macromolecules},
  number    = {6},
  publisher = {ACS Publications},
  address   = {Washington, DC},
  issn      = {1520-5835},
  doi       = {10.1021/acs.macromol.9b02428},
  pages     = {1901 -- 1916},
  year      = {2020},
  abstract  = {The Kremer-Grest (KG) polymer model is a standard model for studying generic polymer properties in molecular dynamics simulations. It owes its popularity to its simplicity and computational efficiency, rather than its ability to represent specific polymers species and conditions. Here we show that by tuning the chain stiffness it is possible to adapt the KG model to model melts of real polymers. In particular, we provide mapping relations from KG to SI units for a wide range of commodity polymers. The connection between the experimental and the KG melts is made at the Kuhn scale, i.e., at the crossover from the chemistry-specific small scale to the universal large scale behavior. We expect Kuhn scale-mapped KG models to faithfully represent universal properties dominated by the large scale conformational statistics and dynamics of flexible polymers. In particular, we observe very good agreement between entanglement moduli of our KG models and the experimental moduli of the target polymers.},
  language  = {en}
}
@article{SchulteZurhausenPoznanska1994,
  author    = {Schulte-Zurhausen, Manfred and Poznanska, K.},
  title     = {Kryteria klasyfikacji malych i srednich przedsiebiorstw = Kriterien zur Klassifizierung von kleinen und mittleren Unternehmen},
  series = {Przeglad Organizacji (1994)},
  journal   = {Przeglad Organizacji (1994)},
  pages     = {24 -- 27},
  year      = {1994},
  language  = {en}
}
@article{Mischke2009,
  author    = {Mischke, Winfried},
  title     = {Kurzkommentierung der \S\S 433, 436, 446 - 453, 474 - 479 BGB},
  series = {LexisNexis : Elektronische Ressource / Recht (2009)},
  journal   = {LexisNexis : Elektronische Ressource / Recht (2009)},
  year      = {2009},
  language  = {en}
}
@article{MeyerGaalenLeschingeretal.2019,
  author    = {Meyer, Carolin and Gaalen, Kerstin van and Leschinger, Tim and Scheyerer, Max J. and Neiss, Wolfram F. and Staat, Manfred and M{\"u}ller, Lars P. and Wegmann, Kilian},
  title     = {Kyphoplasty of Osteoporotic Fractured Vertebrae: A Finite Element Analysis about Two Types of Cement},
  series = {BioMed Research International},
  journal   = {BioMed Research International},
  doi       = {10.1155/2019/9232813},
  pages     = {Article ID 9232813},
  year      = {2019},
  language  = {en}
}
@article{Mayer1997,
  author    = {Mayer, Claudia},
  title     = {L'Est{\´e}tique et le pouvoir: Le discours chaotique de l'Allemagne unifi{\´e}e},
  series = {Canadian review of comparative literature : CRCL = Revue canadienne de litt{\´e}rature compar{\´e}e : RCLC / Canadian Comparative Literature Association. 24 (1997), H. 2},
  journal   = {Canadian review of comparative literature : CRCL = Revue canadienne de litt{\´e}rature compar{\´e}e : RCLC / Canadian Comparative Literature Association. 24 (1997), H. 2},
  isbn      = {0319-051X},
  pages     = {297 -- 317},
  year      = {1997},
  language  = {en}
}
@article{PoghossianIngebrandtAbouzaretal.2007,
  author    = {Poghossian, Arshak and Ingebrandt, S. and Abouzar, Maryam H. and Sch{\"o}ning, Michael Josef},
  title     = {Label-free detection of charged macromolecules by using a field-effect-based sensor platform: Experiments and possible mechanisms of signal generation},
  series = {Applied Physics A: Materials Science \& Processing. 87 (2007), H. 3},
  journal   = {Applied Physics A: Materials Science \& Processing. 87 (2007), H. 3},
  isbn      = {0947-8396},
  pages     = {517 -- 524},
  year      = {2007},
  language  = {en}
}
@article{BronderWuPoghossianetal.2014,
  author    = {Bronder, Thomas and Wu, Chunsheng and Poghossian, Arshak and Werner, Frederik and Keusgen, M. and Sch{\"o}ning, Michael Josef},
  title     = {Label-free detection of DNA hybridization with light-addressable potentiometric sensors: comparison of various DNA-immobilization strategies},
  series = {Procedia Engineering},
  volume    = {87},
  journal   = {Procedia Engineering},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1877-7058},
  doi       = {10.1016/j.proeng.2014.11.647},
  pages     = {755 -- 758},
  year      = {2014},
  abstract  = {Light-addressable potentiometric sensors (LAPS) consisting of a p-Si-SiO2 and p-Si-SiO2-Au structure, respectively, have been tested for a label-free electrical detection of DNA (deoxyribonucleic acid) hybridization. Three different strategies for immobilizing single-stranded probe DNA (ssDNA) molecules on a LAPS surface have been studied and compared: (a) immobilization of thiol-modified ssDNA on the patterned Au surface via gold-thiol bond, (b) covalent immobilization of amino-modified ssDNA onto the SiO2 surface functionalized with 3-aminopropyltriethoxysilane and (c) layer-by-layer adsorption of negatively charged ssDNA on a positively charged weak polyelectrolyte layer of poly(allylamine hydrochloride).},
  language  = {en}
}
@article{WuBronderPoghossianetal.2015,
  author    = {Wu, Chunsheng and Bronder, Thomas and Poghossian, Arshak and Werner, Frederik and Sch{\"o}ning, Michael Josef},
  title     = {Label-free detection of DNA using light-addressable potentiometric sensor modified with a positively charged polyelectrolyte layer},
  series = {Nanoscale},
  volume    = {14},
  journal   = {Nanoscale},
  number    = {7},
  publisher = {Royal Society of Chemistry (RSC)},
  address   = {Cambridge},
  doi       = {10.1039/C4NR07225A},
  pages     = {6143 -- 6150},
  year      = {2015},
  abstract  = {A multi-spot (16 spots) light-addressable potentiometric sensor (MLAPS) consisting of an Al-p-Si-SiO2 structure modified with a weak polyelectrolyte layer of PAH (poly(allylamine hydrochloride)) was applied for the label-free electrical detection of DNA (deoxyribonucleic acid) immobilization and hybridization by the intrinsic molecular charge for the first time. To achieve a preferentially flat orientation of DNA strands and thus, to reduce the distance between the DNA charge and MLAPS surface, the negatively charged probe single-stranded DNAs (ssDNA) were electrostatically adsorbed onto the positively charged PAH layer using a simple layer-by-layer (LbL) technique. In this way, more DNA charge can be positioned within the Debye length, yielding a higher sensor signal. The surface potential changes in each spot induced due to the surface modification steps (PAH adsorption, probe ssDNA immobilization, hybridization with complementary target DNA (cDNA), non-specific adsorption of mismatched ssDNA) were determined from the shifts of photocurrent-voltage curves along the voltage axis. A high sensor signal of 83 mV was registered after immobilization of probe ssDNA onto the PAH layer. The hybridization signal increases from 5 mV to 32 mV with increasing the concentration of cDNA from 0.1 nM to 5 μM. In contrast, a small signal of 5 mV was recorded in the case of non-specific adsorption of fully mismatched ssDNA (5 μM). The obtained results demonstrate the potential of the MLAPS in combination with the simple and rapid LbL immobilization technique as a promising platform for the future development of multi-spot light-addressable label-free DNA chips with direct electrical readout.},
  language  = {en}
}
@article{BronderPoghossianKeusgenetal.2017,
  author    = {Bronder, Thomas and Poghossian, Arshak and Keusgen, Michael and Sch{\"o}ning, Michael Josef},
  title     = {Label-free detection of double-stranded DNA molecules with polyelectrolyte-modified capacitive field-effect sensors},
  series = {tm - Technisches Messen},
  volume    = {84},
  journal   = {tm - Technisches Messen},
  number    = {10},
  publisher = {De Gruyter},
  address   = {Oldenbourg},
  doi       = {10.1515/teme-2017-0015},
  pages     = {628 -- 634},
  year      = {2017},
  abstract  = {In this study, polyelectrolyte-modified field-effect-based electrolyte-insulator-semiconductor (EIS) devices have been used for the label-free electrical detection of double-stranded deoxyribonucleic acid (dsDNA)molecules. The sensor-chip functionalization with a positively charged polyelectrolyte layer provides the possibility of direct adsorptive binding of negatively charged target DNA oligonucleotides onto theSiO2-chip surface.EIS sensors can be utilized as a tool to detect surface-charge changes; the electrostatic adsorption of oligonucleotides onto the polyelectrolyte layer leads to a measureable surface-potential change. Signals of 39mV have been recorded after the incubation with the oligonucleotide solution. Besides the electrochemical experiments, the successful adsorption of dsDNA onto the polyelectrolyte layer has been verified via fluorescence microscopy. The presented results demonstrate that the signal recording of EISchips, which are modified with a polyelectrolyte layer, canbe used as a favorable approach for a fast, cheap and simple detection method for dsDNA.},
  language  = {en}
}
@article{IngebrandtHanNakamuraetal.2007,
  author    = {Ingebrandt, S. and Han, Y. and Nakamura, F. and Poghossian, Arshak and Sch{\"o}ning, Michael Josef and Offenh{\"a}usser, A.},
  title     = {Label-free detection of single nucleotide polymorphisms utilizing the differential transfer function of field-effect transistors},
  series = {Biosensors and Bioelectronics. 22 (2007), H. 12},
  journal   = {Biosensors and Bioelectronics. 22 (2007), H. 12},
  isbn      = {0956-5663},
  pages     = {2834 -- 2840},
  year      = {2007},
  language  = {en}
}
@article{SchoeningBronderWuetal.2017,
  author    = {Sch{\"o}ning, Michael Josef and Bronder, Thomas and Wu, Chunsheng and Scheja, Sabrina and Jessing, Max and Metzger-Boddien, Christoph and Keusgen, Michael and Poghossian, Arshak},
  title     = {Label-Free DNA Detection with Capacitive Field-Effect Devices—Challenges and Opportunities},
  series = {Proceedings},
  volume    = {1},
  journal   = {Proceedings},
  number    = {8},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2504-3900},
  doi       = {10.3390/proceedings1080719},
  pages     = {Artikel 719},
  year      = {2017},
  abstract  = {Field-effect EIS (electrolyte-insulator-semiconductor) sensors modified with a positively charged weak polyelectrolyte layer have been applied for the electrical detection of DNA (deoxyribonucleic acid) immobilization and hybridization by the intrinsic molecular charge. The EIS sensors are able to detect the existence of target DNA amplicons in PCR (polymerase chain reaction) samples and thus, can be used as tool for a quick verification of DNA amplification and the successful PCR process. Due to their miniaturized setup, compatibility with advanced micro- and nanotechnologies, and ability to detect biomolecules by their intrinsic molecular charge, those sensors can serve as possible platform for the development of label-free DNA chips. Possible application fields as well as challenges and limitations will be discussed.},
  language  = {en}
}
@article{AbouzarPedrazaSchoeningetal.2010,
  author    = {Abouzar, Maryam H. and Pedraza, A. M. and Sch{\"o}ning, Michael Josef and Poghossian, Arshak},
  title     = {Label-free DNA hybridization and denaturation detection by means of field-effect nanoplate SOI capacitors functionalized with gold nanoparticles},
  series = {Procedia Engineering. 5 (2010)},
  journal   = {Procedia Engineering. 5 (2010)},
  isbn      = {1877-7058},
  pages     = {918 -- 921},
  year      = {2010},
  language  = {en}
}
@article{AbouzarPoghossianCherstvyetal.2012,
  author    = {Abouzar, Maryam H. and Poghossian, Arshak and Cherstvy, Andrey G. and Pedraza, Angela M. and Ingebrandt, Sven and Sch{\"o}ning, Michael Josef},
  title     = {Label-free electrical detection of DNA by means of field-effect nanoplate capacitors: Experiments and modeling},
  series = {Physica Status Solidi (a)},
  volume    = {209},
  journal   = {Physica Status Solidi (a)},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {1862-6319},
  doi       = {10.1002/pssa.201100710},
  pages     = {925 -- 934},
  year      = {2012},
  abstract  = {Label-free electrical detection of consecutive deoxyribonucleic acid (DNA) hybridization/denaturation by means of an array of individually addressable field-effect-based nanoplate silicon-on-insulator (SOI) capacitors modified with gold nanoparticles (Au-NP) is investigated. The proposed device detects charge changes on Au-NP/DNA hybrids induced by the hybridization or denaturation event. DNA hybridization was performed in a high ionic-strength solution to provide a high hybridization efficiency. On the other hand, to reduce the screening of the DNA charge by counter ions and to achieve a high sensitivity, the sensor signal induced by the hybridization and denaturation events was measured in a low ionic-strength solution. High sensor signals of about 120, 90, and 80 mV were registered after the DNA hybridization, denaturation, and re-hybridization events, respectively. Fluorescence microscopy has been applied as reference method to verify the DNA immobilization, hybridization, and denaturation processes. An electrostatic charge-plane model for potential changes at the gate surface of a nanoplate field-effect sensor induced by the DNA hybridization has been developed taking into account both the Debye length and the distance of the DNA charge from the gate surface.},
  language  = {en}
}
@article{WuBronderPoghossianetal.2014,
  author    = {Wu, Chunsheng and Bronder, Thomas and Poghossian, Arshak and Werner, Frederik and B{\"a}cker, Matthias and Sch{\"o}ning, Michael Josef},
  title     = {Label-free electrical detection of DNA with a multi-spot LAPS: First step towards light-addressable DNA chips},
  series = {Physica status solidi A : Applications and materials science},
  volume    = {211},
  journal   = {Physica status solidi A : Applications and materials science},
  number    = {6},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {1521-396X (E-Journal); 1862-6319 (E-Journal); 0031-8965 (Print); 1862-6300 (Print)},
  doi       = {10.1002/pssa.201330442},
  pages     = {1423 -- 1428},
  year      = {2014},
  abstract  = {A multi-spot (4 × 4 spots) light-addressable potentiometric sensor (MLAPS) consisting of an Al-p-Si-SiO2 structure has been applied for the label-free electrical detection of DNA (deoxyribonucleic acid) immobilization and hybridization by the intrinsic molecular charge for the first time. Single-stranded probe ssDNA molecules (20 bases) were covalently immobilized onto the silanized SiO2 gate surface. The unspecific adsorption of mismatch ssDNA on the MLAPS gate surface was blocked by bovine serum albumin molecules. To reduce the screening effect and to achieve a high sensor signal, the measurements were performed in a low ionic-strength solution. The photocurrent-voltage (I-V) curves were simultaneously recorded on all 16 spots after each surface functionalization step. Large shifts of I-V curves of 25 mV were registered after the DNA immobilization and hybridization event. In contrast, a small potential shift (∼5 mV) was observed in case of mismatch ssDNA, revealing good specificity of the sensor. The obtained results demonstrate the potential of the MLAPS as promising transducer platform for the multi-spot label-free electrical detection of DNA molecules by their intrinsic molecular charge.},
  language  = {en}
}