@article{LeursMezoOehlschlaegeretal.2012,
  author    = {Leurs, Ulrike and Mezo, Gabor and {\"O}hlschl{\"a}ger, Peter and Orban, Erika and Marquard, Andrea and Manea, Marilena},
  title     = {Design, synthesis, in vitro stability and cytostatic effect of multifunctional anticancer drug-bioconjugates containing GnRH-III as a targeting moiety},
  series = {Peptide Science},
  volume    = {98},
  journal   = {Peptide Science},
  number    = {1},
  publisher = {Wiley},
  address   = {New York, NY},
  issn      = {1097-0282},
  doi       = {10.1002/bip.21640},
  pages     = {1 -- 10},
  year      = {2012},
  abstract  = {Bioconjugates containing the GnRH-III hormone decapeptide as a targeting moiety are able to deliver chemotherapeutic agents specifically to cancer cells expressing GnRH receptors, thereby increasing their local efficacy while limiting the peripheral toxicity. However, the number of GnRH receptors on cancer cells is limited and they desensitize under continuous hormone treatment. A possible approach to increase the receptor mediated tumor targeting and consequently the cytostatic effect of the bioconjugates would be the attachment of more than one chemotherapeutic agent to one GnRH-III molecule. Here we report on the design, synthesis and biochemical characterization of multifunctional bioconjugates containing GnRH-III as a targeting moiety and daunorubicin as a chemotherapeutic agent. Two different drug design approaches were pursued. The first one was based on the bifunctional [4Lys]-GnRH-III (Glp-His-Trp-Lys-His-Asp-Trp-Lys-Pro-Gly-NH2) containing two lysine residues in positions 4 and 8, whose ϵ-amino groups were used for the coupling of daunorubicin. In the second drug design, the native GnRH-III (Glp-His-Trp-Ser-His-Asp-Trp-Lys-Pro-Gly-NH2) was used as a scaffold; an additional lysine residue was coupled to the ϵ-amino group of 8Lys in order to generate two free amino groups available for conjugation of daunorubicin. The in vitro stability/degradation of all synthesized compounds was investigated in human serum, as well as in the presence of rat liver lysosomal homogenate. Their cellular uptake was determined on human breast cancer cells and the cytostatic effect was evaluated on human breast, colon and prostate cancer cell lines. Compared with a monofunctional compound, both drug design approaches resulted in multifunctional bioconjugates with increased cytostatic effect.},
  language  = {en}
}
@article{BitzFelderWittig2013,
  author    = {Bitz, Andreas and Felder, Jorg and Wittig, Tilmann},
  title     = {Designing MRI Coils with Aid of Simulation},
  series = {Microwaves \& RF},
  volume    = {52},
  journal   = {Microwaves \& RF},
  number    = {7},
  publisher = {Penton},
  address   = {Cleveland, Ohio},
  issn      = {0745-2993},
  pages     = {56},
  year      = {2013},
  language  = {en}
}
@article{BindalSharmaJanseretal.2013,
  author    = {Bindal, Gaurav and Sharma, Sparsh and Janser, Frank and Neu, Eugen},
  title     = {Detailed analysis of variables affecting wing kinematics of bat flight},
  series = {SAE International Journal of Aerospace},
  volume    = {6},
  journal   = {SAE International Journal of Aerospace},
  number    = {2},
  issn      = {1946-3901},
  doi       = {10.4271/2013-01-9003},
  pages     = {811 -- 818},
  year      = {2013},
  language  = {en}
}
@article{RochefortVerverGrunendahletal.2005,
  author    = {Rochefort, E. de and Verver, M. and Grunendahl, A. and Mooi, H. and Butenweg, Christoph},
  title     = {Detailed modelling of the lumbar spine for investigations of low back pain},
  series = {SAE transactions : papers presented at Society and Section meetings / Society of Automotive Engineers},
  volume    = {Volume 114},
  journal   = {SAE transactions : papers presented at Society and Section meetings / Society of Automotive Engineers},
  number    = {Part 7},
  organization    = {Society of Automotive Engineers},
  issn      = {0096-736X},
  pages     = {788 -- 796},
  year      = {2005},
  language  = {en}
}
@article{GrajewskiKleefeld2023,
  author    = {Grajewski, Matthias and Kleefeld, Andreas},
  title     = {Detecting and approximating decision boundaries in low-dimensional spaces},
  series = {Numerical Algorithms},
  volume    = {93},
  journal   = {Numerical Algorithms},
  number    = {4},
  publisher = {Springer Science+Business Media},
  address   = {Dordrecht},
  issn      = {1572-9265},
  pages     = {35 Seiten},
  year      = {2023},
  abstract  = {A method for detecting and approximating fault lines or surfaces, respectively, or decision curves in two and three dimensions with guaranteed accuracy is presented. Reformulated as a classification problem, our method starts from a set of scattered points along with the corresponding classification algorithm to construct a representation of a decision curve by points with prescribed maximal distance to the true decision curve. Hereby, our algorithm ensures that the representing point set covers the decision curve in its entire extent and features local refinement based on the geometric properties of the decision curve. We demonstrate applications of our method to problems related to the detection of faults, to multi-criteria decision aid and, in combination with Kirsch's factorization method, to solving an inverse acoustic scattering problem. In all applications we considered in this work, our method requires significantly less pointwise classifications than previously employed algorithms.},
  language  = {en}
}
@article{PoghossianSchoening2004,
  author    = {Poghossian, Arshak and Sch{\"o}ning, Michael Josef},
  title     = {Detecting Both Physical and (Bio-)Chemical Parameters by Means of ISFET Devices},
  series = {Electroanalysis. 16 (2004), H. 22},
  journal   = {Electroanalysis. 16 (2004), H. 22},
  isbn      = {1040-0397},
  pages     = {1863 -- 1872},
  year      = {2004},
  language  = {en}
}
@article{AllefeldBialonski2007,
  author    = {Allefeld, Carsten and Bialonski, Stephan},
  title     = {Detecting synchronization clusters in multivariate time series via coarse-graining of Markov chains},
  series = {Physical Review E},
  volume    = {76},
  journal   = {Physical Review E},
  number    = {6},
  issn      = {2470-0053},
  doi       = {10.1103/PhysRevE.76.066207},
  pages     = {066207},
  year      = {2007},
  language  = {en}
}
@article{SchmichEdererEbert1992,
  author    = {Schmich, Peter and Ederer, Hanns J. and Ebert, Klaus H.},
  title     = {Detection and identification of free radicals in hydrocarbon pyrolysis by an iodine trapping method},
  series = {Industrial \& Engineering Chemistry Research. 31 (1992), H. 1},
  journal   = {Industrial \& Engineering Chemistry Research. 31 (1992), H. 1},
  isbn      = {1520-5045},
  pages     = {29 -- 37},
  year      = {1992},
  language  = {en}
}
@article{WeldenSeverinsPoghossianetal.2022,
  author    = {Welden, Melanie and Severins, Robin and Poghossian, Arshak and Wege, Christina and Bongaerts, Johannes and Siegert, Petra and Keusgen, Michael and Sch{\"o}ning, Michael Josef},
  title     = {Detection of acetoin and diacetyl by a tobacco mosaic virus-assisted field-effect biosensor},
  series = {Chemosensors},
  volume    = {10},
  journal   = {Chemosensors},
  number    = {6},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2227-9040},
  doi       = {10.3390/chemosensors10060218},
  pages     = {Artikel 218},
  year      = {2022},
  abstract  = {Acetoin and diacetyl have a major impact on the flavor of alcoholic beverages such as wine or beer. Therefore, their measurement is important during the fermentation process. Until now, gas chromatographic techniques have typically been applied; however, these require expensive laboratory equipment and trained staff, and do not allow for online monitoring. In this work, a capacitive electrolyte-insulator-semiconductor sensor modified with tobacco mosaic virus (TMV) particles as enzyme nanocarriers for the detection of acetoin and diacetyl is presented. The enzyme acetoin reductase from Alkalihalobacillus clausii DSM 8716ᵀ is immobilized via biotin-streptavidin affinity, binding to the surface of the TMV particles. The TMV-assisted biosensor is electrochemically characterized by means of leakage-current, capacitance-voltage, and constant capacitance measurements. In this paper, the novel biosensor is studied regarding its sensitivity and long-term stability in buffer solution. Moreover, the TMV-assisted capacitive field-effect sensor is applied for the detection of diacetyl for the first time. The measurement of acetoin and diacetyl with the same sensor setup is demonstrated. Finally, the successive detection of acetoin and diacetyl in buffer and in diluted beer is studied by tuning the sensitivity of the biosensor using the pH value of the measurement solution.},
  language  = {en}
}
@article{MolinnusBaeckerSiegertetal.2015,
  author    = {Molinnus, Denise and B{\"a}cker, Matthias and Siegert, Petra and Willenberg, H. and Poghossian, Arshak and Keusgen, M. and Sch{\"o}ning, Michael Josef},
  title     = {Detection of Adrenaline Based on Substrate Recycling Amplification},
  series = {Procedia Engineering},
  volume    = {120},
  journal   = {Procedia Engineering},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1877-7058},
  doi       = {10.1016/j.proeng.2015.08.708},
  pages     = {540 -- 543},
  year      = {2015},
  abstract  = {An amperometric enzyme biosensor has been applied for the detection of adrenaline. The adrenaline biosensor has been prepared by modification of an oxygen electrode with the enzyme laccase that operates at a broad pH range between pH 3.5 to pH 8. The enzyme molecules were immobilized via cross-linking with glutaraldehyde. The sensitivity of the developed adrenaline biosensor in different pH buffer solutions has been studied.},
  language  = {en}
}
@article{MolinnusHardtSiegertetal.2018,
  author    = {Molinnus, Denise and Hardt, Gabriel and Siegert, Petra and Willenberg, Holger S. and Poghossian, Arshak and Keusgen, Michael and Sch{\"o}ning, Michael Josef},
  title     = {Detection of Adrenaline in Blood Plasma as Biomarker for Adrenal Venous Sampling},
  series = {Electroanalysis},
  volume    = {30},
  journal   = {Electroanalysis},
  number    = {5},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {1521-4109},
  doi       = {10.1002/elan.201800026},
  pages     = {937 -- 942},
  year      = {2018},
  abstract  = {An amperometric bi-enzyme biosensor based on substrate recycling principle for the amplification of the sensor signal has been developed for the detection of adrenaline in blood. Adrenaline can be used as biomarker verifying successful adrenal venous sampling procedure. The adrenaline biosensor has been realized via modification of a galvanic oxygen sensor with a bi-enzyme membrane combining a genetically modified laccase and a pyrroloquinoline quinone-dependent glucose dehydrogenase. The measurement conditions such as pH value and temperature were optimized to enhance the sensor performance. A high sensitivity and a low detection limit of about 0.5-1 nM adrenaline have been achieved in phosphate buffer at pH 7.4, relevant for measurements in blood samples. The sensitivity of the biosensor to other catecholamines such as noradrenaline, dopamine and dobutamine has been studied. Finally, the sensor has been successfully applied for the detection of adrenaline in human blood plasma.},
  language  = {en}
}
@article{SchoeningPoghossian2008,
  author    = {Sch{\"o}ning, Michael Josef and Poghossian, Arshak},
  title     = {Detection of charged macromolecules by means of field-effect devices (FEDs): possibilities and limitations},
  series = {Electrochemical sensors, biosensors and their biomedical applications / ed. by Xueji Zhang ...},
  journal   = {Electrochemical sensors, biosensors and their biomedical applications / ed. by Xueji Zhang ...},
  publisher = {Elsevier Acad. Press},
  address   = {Amsterdam},
  isbn      = {978-0-12-373738-0},
  pages     = {187 -- 212},
  year      = {2008},
  language  = {en}
}
@article{HerberErnstBussetal.1999,
  author    = {Herber, R. and Ernst, S. and Buß, G. and Sch{\"o}ning, Michael Josef and Baltruschat, H.},
  title     = {Detection of hydrocarbons in air and water by adsorption on Pt electrodes using continuous impedance measurements},
  series = {Proceedings of the Symposium on New Directions in Electroanalytical Chemistry II : [held at the 195th Meeting of the Electrochemical Society in Seattle, Washington on May 3 and 4, 1999] / Physical Electrochemistry, Sensor, and Organic and Biological Electrochemistry Divisions. Ed.: J. Leddy, P. Vanysek, M.D. Porter},
  journal   = {Proceedings of the Symposium on New Directions in Electroanalytical Chemistry II : [held at the 195th Meeting of the Electrochemical Society in Seattle, Washington on May 3 and 4, 1999] / Physical Electrochemistry, Sensor, and Organic and Biological Electrochemistry Divisions. Ed.: J. Leddy, P. Vanysek, M.D. Porter},
  publisher = {Electrochemical Society},
  address   = {Pennington, NJ},
  isbn      = {1-56677-227-3},
  pages     = {168 -- 177},
  year      = {1999},
  language  = {en}
}
@article{OberlaenderKirchnerBoyenetal.2014,
  author    = {Oberl{\"a}nder, Jan and Kirchner, Patrick and Boyen, Hans-Gerd and Sch{\"o}ning, Michael Josef},
  title     = {Detection of hydrogen peroxide vapor by use of manganese(IV) oxide as catalyst for calorimetric gas sensors},
  series = {Physica status solidi A: Applications and materials science},
  volume    = {211},
  journal   = {Physica status solidi A: Applications and materials science},
  number    = {6},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {1521-396X (E-Journal); 1862-6319 (E-Journal); 0031-8965 (Print); 1862-6300 (Print)},
  doi       = {10.1002/pssa.201330359},
  pages     = {1372 -- 1376},
  year      = {2014},
  abstract  = {In this work, the catalyst manganese(IV) oxide (MnO2), of calorimetric gas sensors (to monitor the sterilization agent vaporized hydrogen peroxide) has been investigated in more detail. Chemical analyses by means of X-ray-induced photoelectron spectroscopy have been performed to unravel the surface chemistry prior and after exposure to hydrogen peroxide vapor at elevated temperature, as applied in the sterilization processes of beverage cartons. The surface characterization reveals a change in oxidation states of the metal oxide catalyst after exposure to hydrogen peroxide. Additionally, a cleaning effect of the catalyst, which itself is attached to the sensor surface by means of a polymer interlayer, could be observed.},
  language  = {en}
}
@article{KassabHanPoghossianetal.2004,
  author    = {Kassab, T. and Han, Y. and Poghossian, Arshak and Ingebrandt, S. and Offenh{\"a}usser, A. and Sch{\"o}ning, Michael Josef},
  title     = {Detection of layerby-layer adsorbed polyelectrolytes by means of field-effect based capacitive EIS structures},
  series = {Biomedizinische Technik. 49 (2004), H. 2},
  journal   = {Biomedizinische Technik. 49 (2004), H. 2},
  isbn      = {0932-4666},
  pages     = {1034 -- 1035},
  year      = {2004},
  language  = {en}
}
@article{EmonsHuellenkremerSchoening2001,
  author    = {Emons, H. and H{\"u}llenkremer, B. and Sch{\"o}ning, Michael Josef},
  title     = {Detection of metal ions in aqueous solutions by voltohmmetry},
  series = {Fresenius' Journal of Analytical Chemistry. 369 (2001), H. 1},
  journal   = {Fresenius' Journal of Analytical Chemistry. 369 (2001), H. 1},
  isbn      = {0937-0633},
  pages     = {42 -- 46},
  year      = {2001},
  language  = {en}
}
@article{BronderJessingPoghossianetal.2018,
  author    = {Bronder, Thomas and Jessing, Max P. and Poghossian, Arshak and Keusgen, Michael and Sch{\"o}ning, Michael Josef},
  title     = {Detection of PCR-Amplified Tuberculosis DNA Fragments with Polyelectrolyte-Modified Field-Effect Sensors},
  series = {Analytical Chemistry},
  volume    = {90},
  journal   = {Analytical Chemistry},
  number    = {12},
  publisher = {ACS Publications},
  address   = {Washington, DC},
  issn      = {0003-2700},
  doi       = {10.1021/acs.analchem.8b01807},
  pages     = {7747 -- 7753},
  year      = {2018},
  abstract  = {Field-effect-based electrolyte-insulator-semiconductor (EIS) sensors were modified with a bilayer of positively charged weak polyelectrolyte (poly(allylamine hydrochloride) (PAH)) and probe single-stranded DNA (ssDNA) and are used for the detection of complementary single-stranded target DNA (cDNA) in different test solutions. The sensing mechanism is based on the detection of the intrinsic molecular charge of target cDNA molecules after the hybridization event between cDNA and immobilized probe ssDNA. The test solutions contain synthetic cDNA oligonucleotides (with a sequence of tuberculosis mycobacteria genome) or PCR-amplified DNA (which origins from a template DNA strand that has been extracted from Mycobacterium avium paratuberculosis-spiked human sputum samples), respectively. Sensor responses up to 41 mV have been measured for the test solutions with DNA, while only small signals of ∼5 mV were detected for solutions without DNA. The lower detection limit of the EIS sensors was ∼0.3 nM, and the sensitivity was ∼7.2 mV/decade. Fluorescence experiments using SybrGreen I fluorescence dye support the electrochemical results.},
  language  = {en}
}
@article{JablonskiPoghossianKeusgenetal.2021,
  author    = {Jablonski, Melanie and Poghossian, Arshak and Keusgen, Michael and Wege, Christina and Sch{\"o}ning, Michael Josef},
  title     = {Detection of plant virus particles with a capacitive field-effect sensor},
  series = {Analytical and Bioanalytical Chemistry},
  volume    = {413},
  journal   = {Analytical and Bioanalytical Chemistry},
  publisher = {Springer Nature},
  address   = {Cham},
  issn      = {1618-2650},
  doi       = {10.1007/s00216-021-03448-8},
  pages     = {5669 -- 5678},
  year      = {2021},
  abstract  = {Plant viruses are major contributors to crop losses and induce high economic costs worldwide. For reliable, on-site and early detection of plant viral diseases, portable biosensors are of great interest. In this study, a field-effect SiO2-gate electrolyte-insulator-semiconductor (EIS) sensor was utilized for the label-free electrostatic detection of tobacco mosaic virus (TMV) particles as a model plant pathogen. The capacitive EIS sensor has been characterized regarding its TMV sensitivity by means of constant-capacitance method. The EIS sensor was able to detect biotinylated TMV particles from a solution with a TMV concentration as low as 0.025 nM. A good correlation between the registered EIS sensor signal and the density of adsorbed TMV particles assessed from scanning electron microscopy images of the SiO2-gate chip surface was observed. Additionally, the isoelectric point of the biotinylated TMV particles was determined via zeta potential measurements and the influence of ionic strength of the measurement solution on the TMV-modified EIS sensor signal has been studied.},
  language  = {en}
}
@article{WarmerWagnerSchoeningetal.2015,
  author    = {Warmer, Johannes and Wagner, Patrick and Sch{\"o}ning, Michael Josef and Kaul, Peter},
  title     = {Detection of triacetone triperoxide using temperature cycled metal-oxide semiconductor gas sensors},
  series = {Physica status solidi (a)},
  volume    = {212},
  journal   = {Physica status solidi (a)},
  number    = {6},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {1862-6319},
  doi       = {10.1002/pssa.201431882},
  pages     = {1289 -- 1298},
  year      = {2015},
  language  = {en}
}
@article{SchoppRohrbachLangeretal.2024,
  author    = {Schopp, Christoph and Rohrbach, Felix and Langer, Luc and Heuermann, Holger},
  title     = {Detection of welding wire length by active S11 measurement},
  series = {IEEE Transactions on Plasma Science},
  journal   = {IEEE Transactions on Plasma Science},
  number    = {Early Access},
  publisher = {IEEE},
  issn      = {0093-3813 (Print)},
  doi       = {10.1109/TPS.2024.3356659},
  pages     = {1 -- 6},
  year      = {2024},
  abstract  = {A novel method to determine the extruded length of a metallic wire for a directed energy deposition (DED) process using a microwave (MW) plasma jet with a straight-through wire feed is presented. The method is based on the relative comparison of the measured frequency response obtained by the large-signal scattering parameter (Hot-S) technique. In the practical working range, repeatability of less than 6\% for a nonactive plasma and 9\% for the active plasma state is found. Measurements are conducted with a focus on a simple solution to decrease the processing time and reduce the integration time of the process into the existing hardware. It is shown that monitoring a single frequency for magnitude and phase changes is sufficient to achieve good accuracy. A combination of different measurement values to determine the length is possible. The applicability to different diameter of the same material is shown as well as a contact detection of the wire and metallic substrate.},
  language  = {en}
}