@article{HeuermannIbrahim2009, author = {Heuermann, Holger and Ibrahim, Irfan}, title = {Improvements in the flicker noise reduction technique for osillator designs / Ibrahim, Irfan ; Heuermann, Holger}, series = {European Microwave Conference, 2009 : EuMC 2009 ; Sept. 29, 2009 - Oct. 1, 2009, Rome, Italy ; part of European Microwave Week (EuMW) / sponsored by EuMA, European Microwave Association ... Endorsed by IEEE}, journal = {European Microwave Conference, 2009 : EuMC 2009 ; Sept. 29, 2009 - Oct. 1, 2009, Rome, Italy ; part of European Microwave Week (EuMW) / sponsored by EuMA, European Microwave Association ... Endorsed by IEEE}, publisher = {IEEE}, address = {Piscataway, NJ}, isbn = {978-1-4244-4748-0}, pages = {1215 -- 1218}, year = {2009}, language = {en} } @inproceedings{AlhwarinFerreinGebhardtetal.2015, author = {Alhwarin, Faraj and Ferrein, Alexander and Gebhardt, Andreas and Kallweit, Stephan and Scholl, Ingrid and Tedjasukmana, Osmond Sanjaya}, title = {Improving additive manufacturing by image processing and robotic milling}, series = {2015 IEEE International Conference on Automation Science and Engineering (CASE), Aug 24-28, 2015 Gothenburg, Sweden}, booktitle = {2015 IEEE International Conference on Automation Science and Engineering (CASE), Aug 24-28, 2015 Gothenburg, Sweden}, doi = {10.1109/CoASE.2015.7294217}, pages = {924 -- 929}, year = {2015}, language = {en} } @inproceedings{MeckMuellerAltherretal.2020, author = {Meck, Marvin M. and M{\"u}ller, Tim M. and Altherr, Lena and Pelz, Peter F.}, title = {Improving an industrial cooling system using MINLP, considering capital and operating costs}, series = {Operations Research Proceedings 2019}, booktitle = {Operations Research Proceedings 2019}, publisher = {Springer}, address = {Cham}, isbn = {978-3-030-48438-5 (Print)}, doi = {10.1007/978-3-030-48439-2_61}, pages = {505 -- 512}, year = {2020}, abstract = {The chemical industry is one of the most important industrial sectors in Germany in terms of manufacturing revenue. While thermodynamic boundary conditions often restrict the scope for reducing the energy consumption of core processes, secondary processes such as cooling offer scope for energy optimisation. In this contribution, we therefore model and optimise an existing cooling system. The technical boundary conditions of the model are provided by the operators, the German chemical company BASF SE. In order to systematically evaluate different degrees of freedom in topology and operation, we formulate and solve a Mixed-Integer Nonlinear Program (MINLP), and compare our optimisation results with the existing system.}, language = {en} } @book{Drumm2008, author = {Drumm, Christian}, title = {Improving Schema Mapping by Exploiting Domain Knowledge}, pages = {235 S.}, year = {2008}, language = {en} } @article{SchrothSchoeningSchuetzetal.1999, author = {Schroth, P. and Sch{\"o}ning, Michael Josef and Sch{\"u}tz, S. and Epanya, P. and Steffen, A. and Weißbecker, B. and Hummel, Hans E. and Kordos, P. and L{\"u}th, H.}, title = {Improving the bioelectronic interface of an antenna/chip biosensor - technological aspects}, series = {Proceedings : The Hague, The Netherlands, September 12 - 15, 1999 / [ed. by M. Bartek]. Vol 1.}, journal = {Proceedings : The Hague, The Netherlands, September 12 - 15, 1999 / [ed. by M. Bartek]. Vol 1.}, address = {The Hague, The Netherlands}, isbn = {90-76699-02-X}, pages = {569 -- 572}, year = {1999}, language = {en} } @article{ThustSchrothToepleretal.1998, author = {Thust, M. and Schroth, P. and T{\"o}pler, A. and Sch{\"o}ning, Michael Josef and M{\"u}ller-Veggian, Mattea and Kordos, P. and L{\"u}th, H.}, title = {Improving the detection limit of a capacitive sensor by means of a diffusion barrier}, series = {Eurosensors XII : proceedings of the 12th European Conference on Solid-State Transducers and the 9th UK Conference on Sensors and their Applications, Southampton, UK, 13 - 16 September 1998 / ed. by N. M. White ; Vol. 1}, journal = {Eurosensors XII : proceedings of the 12th European Conference on Solid-State Transducers and the 9th UK Conference on Sensors and their Applications, Southampton, UK, 13 - 16 September 1998 / ed. by N. M. White ; Vol. 1}, publisher = {Inst. of Physics Publ.}, address = {Bristol [u.a.]}, isbn = {0-7503-0595-9}, pages = {507 -- 510}, year = {1998}, language = {en} } @article{CosmaKesslerGebhardtetal.2020, author = {Cosma, Cosmin and Kessler, Julia and Gebhardt, Andreas and Campbell, Ian and Balc, Nicolae}, title = {Improving the Mechanical Strength of Dental Applications and Lattice Structures SLM Processed}, series = {Materials}, volume = {13}, journal = {Materials}, number = {4}, publisher = {MDPI}, address = {Basel}, issn = {1996-1944}, doi = {10.3390/ma13040905}, pages = {1 -- 18}, year = {2020}, abstract = {To manufacture custom medical parts or scaffolds with reduced defects and high mechanical characteristics, new research on optimizing the selective laser melting (SLM) parameters are needed. In this work, a biocompatible powder, 316L stainless steel, is characterized to understand the particle size, distribution, shape and flowability. Examination revealed that the 316L particles are smooth, nearly spherical, their mean diameter is 39.09 μm and just 10\% of them hold a diameter less than 21.18 μm. SLM parameters under consideration include laser power up to 200 W, 250-1500 mm/s scanning speed, 80 μm hatch spacing, 35 μm layer thickness and a preheated platform. The effect of these on processability is evaluated. More than 100 samples are SLM-manufactured with different process parameters. The tensile results show that is possible to raise the ultimate tensile strength up to 840 MPa, adapting the SLM parameters for a stable processability, avoiding the technological defects caused by residual stress. Correlating with other recent studies on SLM technology, the tensile strength is 20\% improved. To validate the SLM parameters and conditions established, complex bioengineering applications such as dental bridges and macro-porous grafts are SLM-processed, demonstrating the potential to manufacture medical products with increased mechanical resistance made of 316L.}, language = {en} } @inproceedings{ThomaFisherBraun2020, author = {Thoma, Andreas and Fisher, Alex and Braun, Carsten}, title = {Improving the px4 avoid algorithm by bio-inspired flight strategies}, series = {DLRK2020 - „Luft- und Raumfahrt - Verantwortung in allen Dimensionen"}, booktitle = {DLRK2020 - „Luft- und Raumfahrt - Verantwortung in allen Dimensionen"}, doi = {10.25967/530183}, pages = {10 Seiten}, year = {2020}, language = {en} } @article{NoureddineKraffLaddetal.2017, author = {Noureddine, Yacine and Kraff, Oliver and Ladd, Mark E. and Wrede, Karsten H. and Chen, Bixia and Quick, Harald H. and Schaefers, Gregor and Bitz, Andreas}, title = {In vitro and in silico assessment of RF-induced heating around intracranial aneurysm clips at 7 Tesla}, series = {Magnetic Resonance in Medicine}, journal = {Magnetic Resonance in Medicine}, number = {Early view}, publisher = {Wiley}, address = {Weinheim}, issn = {1522-2594}, doi = {10.1002/mrm.26650}, pages = {14 Seiten}, year = {2017}, language = {en} } @article{TemizArtmannResmiAkhunlaretal.2005, author = {Temiz Artmann, Ayseg{\"u}l and Resmi, Halil and Akhunlar, H{\"u}lya and G{\"u}ner, G{\"u}l}, title = {In vitro effects of high glucose concentrations on membrane protein sulfhydryl oxidation, G-actin and deformability of human erythrocytes. Resmi, Halil ; Akhunlar, H{\"u}lya ; Temiz Artmann, Ayseg{\"u}l ; G{\"u}ner, G{\"u}l}, series = {Cell biochemistry and function. 23 (2005), H. 3}, journal = {Cell biochemistry and function. 23 (2005), H. 3}, isbn = {0263-6484}, pages = {163 -- 168}, year = {2005}, language = {en} } @article{TemizArtmannBaşkurtEdremitlioglu1994, author = {Temiz Artmann, Ayseg{\"u}l and Ba{\c{s}}kurt, Oǧuz Kerim and Edremitlioglu, M.}, title = {In vitro effects of in vivo activated leukocytes on red blood cell filterability and lipid peroxidation. Baskurt, O.K.; Edremitlioglu, M.; Temiz, A.}, series = {Clinical Hemorheology. 14 (1994), H. 4}, journal = {Clinical Hemorheology. 14 (1994), H. 4}, pages = {591 -- 596}, year = {1994}, language = {en} } @article{BleilevensHillGrzannaetal.2019, author = {Bleilevens, Christian and Hill, Aileen and Grzanna, Tim and Fechter, Tamara and Bohnen, Melanie and Weber, Hans-Joachim and Beckers, Christian and Borosch, Sebastian and Zayat, Rashad and Benstoem, Carin and Rossaint, Rolf and Goetzenich, Andreas}, title = {In vitro head-to-head comparison of anticoagulation properties of two heparin brands in a human blood miniature mock loop}, series = {Interactive cardiovascular and thoracic surgery}, volume = {28}, journal = {Interactive cardiovascular and thoracic surgery}, number = {1}, issn = {1569-9285}, doi = {10.1093/icvts/ivy206}, pages = {120 -- 127}, year = {2019}, language = {en} } @article{BrockhausBehbahaniMurisetal.2021, author = {Brockhaus, Moritz K. and Behbahani, Mehdi and Muris, Farina and Jansen, Sebastian V. and Schmitz-Rode, Thomas and Steinseifer, Ulrich and Clauser, Johanna C.}, title = {In vitro thrombogenicity testing of pulsatile mechanical circulatory support systems: Design and proof-of-concept}, series = {Artificial Organs}, volume = {45}, journal = {Artificial Organs}, number = {12}, publisher = {Wiley}, address = {Weinheim}, issn = {1525-1594}, doi = {10.1111/aor.14046}, pages = {1513 -- 1521}, year = {2021}, abstract = {Thrombogenic complications are a main issue in mechanical circulatory support (MCS). There is no validated in vitro method available to quantitatively assess the thrombogenic performance of pulsatile MCS devices under realistic hemodynamic conditions. The aim of this study is to propose a method to evaluate the thrombogenic potential of new designs without the use of complex in-vivo trials. This study presents a novel in vitro method for reproducible thrombogenicity testing of pulsatile MCS systems using low molecular weight heparinized porcine blood. Blood parameters are continuously measured with full blood thromboelastometry (ROTEM; EXTEM, FIBTEM and a custom-made analysis HEPNATEM). Thrombus formation is optically observed after four hours of testing. The results of three experiments are presented each with two parallel loops. The area of thrombus formation inside the MCS device was reproducible. The implantation of a filter inside the loop catches embolizing thrombi without a measurable increase of platelet activation, allowing conclusions of the place of origin of thrombi inside the device. EXTEM and FIBTEM parameters such as clotting velocity (α) and maximum clot firmness (MCF) show a total decrease by around 6\% with a characteristic kink after 180 minutes. HEPNATEM α and MCF rise within the first 180 minutes indicate a continuously increasing activation level of coagulation. After 180 minutes, the consumption of clotting factors prevails, resulting in a decrease of α and MCF. With the designed mock loop and the presented protocol we are able to identify thrombogenic hot spots inside a pulsatile pump and characterize their thrombogenic potential.}, language = {en} } @article{KobusBitzUdenetal.2012, author = {Kobus, Thiele and Bitz, Andreas and Uden, Mark J. van and Lagemaat, Miram W. and Rothgang, Eva and Orzada, Stephan and Heerschap, Arend and Scheenen, Tom W. J.}, title = {In vivo 31P MR spectroscopic imaging of the human prostate at 7 T: safety and feasibility}, series = {Magnetic Resonance in Medicine}, volume = {68}, journal = {Magnetic Resonance in Medicine}, number = {6}, publisher = {Wiley-Liss}, address = {New York}, issn = {1522-2594}, doi = {10.1002/mrm.24175}, pages = {1683 -- 1695}, year = {2012}, abstract = {31P MR spectroscopic imaging of the human prostate provides information about phosphorylated metabolites that could be used for prostate cancer characterization. The sensitivity of a magnetic field strength of 7 T might enable 3D 31P MR spectroscopic imaging with relevant spatial resolution in a clinically acceptable measurement time. To this end, a 31P endorectal coil was developed and combined with an eight-channel 1H body-array coil to relate metabolic information to anatomical location. An extensive safety validation was performed to evaluate the specific absorption rate, the radiofrequency field distribution, and the temperature distribution of both coils. This validation consisted of detailed Finite Integration Technique simulations, confirmed by MR thermometry and Burn:x-wiley:07403194:media:MRM24175:tex2gif-stack-1 measurements in a phantom and in vivo temperature measurements. The safety studies demonstrated that the presence of the 31P endorectal coil had no influence on the specific absorption rate levels and temperature distribution of the external eight-channel 1H array coil. To stay within a 10 g averaged local specific absorption rate of 10 W/kg, a maximum time-averaged input power of 33 W for the 1H array coil was allowed. For transmitting with the 31P endorectal coil, our safety limit of less than 1°C temperature increase in vivo during a 15-min MR spectroscopic imaging experiment was reached at a time-averaged input power of 1.9 W. With this power setting, a second in vivo measurement was performed on a healthy volunteer. Using adiabatic excitation, 3D 31P MR spectroscopic imaging produced spectra from the entire prostate in 18 min with a spatial resolution of 4 cm3. The spectral resolution enabled the separate detection of phosphocholine, phosphoethanolamine, inorganic phosphate, and other metabolites that could play an important role in the characterization of prostate cancer.}, language = {en} } @inproceedings{WeberPorschenDietzel1978, author = {Weber, Hans-Joachim and Porschen, W. and Dietzel, F.}, title = {In vivo analysis of the influence of combined hyperthermia and gamma irradiation on euoxic and hypoxic tumor cells}, series = {Cancer therapy by hyperthermia and radiation : [proceedings of the 2. International Symposium on Cancer Therapy by Hyperthermia and Radiation, Essen, 2.-4.6.1977]}, booktitle = {Cancer therapy by hyperthermia and radiation : [proceedings of the 2. International Symposium on Cancer Therapy by Hyperthermia and Radiation, Essen, 2.-4.6.1977]}, editor = {Streffer, Christian}, publisher = {Urban and Schwarzenberg}, address = {Baltimore ; Munich [u.a.]}, isbn = {0-8067-1701-7}, pages = {276 -- 277}, year = {1978}, language = {en} } @article{PorschenGartzenGewehretal.1978, author = {Porschen, W. and Gartzen, J. and Gewehr, K. and M{\"u}hlensiepen, H. and Weber, Hans-Joachim and Feinedegen, L E.}, title = {In vivo assay of the radiation sensitivity of hypoxic tumour cells : influence of γ-rays, cyclotron neutrons, misonidazole, hyperthermia and mixed modalities}, series = {The British journal of cancer / Supplement}, journal = {The British journal of cancer / Supplement}, number = {3}, publisher = {Lewis}, address = {London}, issn = {0306-9443}, pages = {194 -- 197}, year = {1978}, abstract = {Tumour cell death can be evaluated in the living mouse by externally measuring the rate of loss of tumour-bound DNA tracer. By sequentially labelling the tumour-bearing animals with ¹²⁵IUdR and ¹³¹IUdR 50 h apart, the average tumour cells at the time of the second injection are labelled by ¹²⁵IUdR and the euoxic tumour cells are specifically labelled with ¹³¹IUdR. Tumour treatment at this stage of labelling permits the observation of the reaction of euoxic cells and average tumour cells and finally yields data on hypoxic cells and thus on the oxygen enhancement ratio. This information adds to results from tumour control and growth delay. With this technique effects were analysed of 60-Co γ-rays, cyclotron neutrons (E = 6 MeV), misonidazole (500 mg/kg body wt) and hyperthermia (42°C water-bath), or combinations of these. Misonidazole (15 min before irradiation) altered the oxygen enhancement ratio by a factor of 1·5 for γ-rays and of 1·1 for neutrons; when evaluated from tumour-growth delay and TCD-50 misonidazole gave a dose modifying factor of 1·47 for γ-rays and of 1·2-1·3 for neutrons. Based on percentage tumour regression 100 days after treatment, the enhancement ratio from hyperthermia (after irradiation) was 2·75 for γ-rays (at 10 Gray) and 2·2 for neutrons (at 3·2 Gray). For neutrons combined with misonidazole and hyperthermia the ratio was 2·4. These results demonstrate that effects of neutron irradiation may be modified by electron-affinic substances and/or hyperthermia.}, language = {en} } @inproceedings{RichterBraunsteinStaeudleetal.2018, author = {Richter, Charlotte and Braunstein, Bjoern and St{\"a}udle, Benjamin and Attias, Julia and Suess, Alexander and Weber, T. and Rittweger, Joern and Green, David A. and Albracht, Kirsten}, title = {In vivo fascicle length of the gastrocnemius muscle during walking in simulated martian gravity using two different body weight support devices}, series = {23rd Annual Congress of the European College of Sport Science, Dublin, Irland}, booktitle = {23rd Annual Congress of the European College of Sport Science, Dublin, Irland}, year = {2018}, language = {en} } @article{ScheerRossKapelyukhetal.2010, author = {Scheer, Nico and Ross, Jillian and Kapelyukh, Yury and Rode, Anja and Wolf, C. Roland}, title = {In vivo responses of the human and murine pregnane X receptor to dexamethasone in mice}, series = {Drug Metabolism and Disposition}, volume = {38}, journal = {Drug Metabolism and Disposition}, number = {7}, publisher = {ASPET}, address = {Bethesda}, issn = {1521-009X}, doi = {10.1124/dmd.109.031872}, pages = {1046 -- 1053}, year = {2010}, abstract = {Dexamethasone (DEX) is a potent and widely used anti-inflammatory and immunosuppressant glucocorticoid. It can bind and activate the pregnane X receptor (PXR), which plays a critical role as xenobiotic sensor in mammals to induce the expression of many enzymes, including cytochromes P450 in the CYP3A family. This induction results in its own metabolism. We have used a series of transgenic mouse lines, including a novel, improved humanized PXR line, to compare the induction profile of PXR-regulated drug-metabolizing enzymes after DEX administration, as well as looking at hepatic responses to rifampicin (RIF). The new humanized PXR model has uncovered further intriguing differences between the human and mouse receptors in that RIF only induced Cyp2b10 in the new humanized model. DEX was found to be a much more potent inducer of Cyp3a proteins in wild-type mice than in mice humanized for PXR. To assess whether PXR is involved in the detoxification of DEX in the liver, we analyzed the consequences of high doses of the glucocorticoid on hepatotoxicity on different PXR genetic backgrounds. We also studied these effects in an additional mouse model in which functional mouse Cyp3a genes have been deleted. These strains exhibited different sensitivities to DEX, indicating a protective role of the PXR and CYP3A proteins against the hepatotoxicity of this compound.}, language = {en} } @article{MuellerVeggianHaenniBeuscheretal.1979, author = {M{\"u}ller-Veggian, Mattea and Haenni, D. R. and Beuscher, H. and Lieder, R. M.}, title = {In-beam studies of ¹⁴⁵ Gd and ¹⁴⁵ Eu}, series = {Fr{\"u}hjahrstagung ... des Fachausschusses Kernphysik und Hochenergiephysik der DPG (Sektion A: Kernphysik) / Deutsche Physikalische Gesellschaft (1979)}, journal = {Fr{\"u}hjahrstagung ... des Fachausschusses Kernphysik und Hochenergiephysik der DPG (Sektion A: Kernphysik) / Deutsche Physikalische Gesellschaft (1979)}, year = {1979}, language = {en} } @article{MuellerVeggianZuberGueven1988, author = {M{\"u}ller-Veggian, Mattea and Zuber, K. and Gueven, H.}, title = {In-beam study of 63 143 Eu 80}, series = {Zeitschrift f{\"u}r Physik / A, Hadrons and nuclei. 330 (1988), H. 3}, journal = {Zeitschrift f{\"u}r Physik / A, Hadrons and nuclei. 330 (1988), H. 3}, isbn = {1431-5831}, pages = {343 -- 344}, year = {1988}, language = {en} }