@article{PrumeTyholdtCalameetal.2007, author = {Prume, Klaus and Tyholdt, F. and Calame, F. and Raeder, H.}, title = {Chemically derived seeding layer for {100}-textured PZT thin films / Tyholdt, F. ; Calame, F. ; Prume, K. ; Raeder, H. ; Muralt, P.}, series = {Journal of Electroceramics. 19 (2007), H. 4}, journal = {Journal of Electroceramics. 19 (2007), H. 4}, isbn = {1385-3449}, pages = {311 -- 314}, year = {2007}, language = {en} } @article{DuennwaldDemirSiegertetal.2001, author = {D{\"u}nnwald, Thomas and Demir, Ayhan S. and Siegert, Petra and Pohl, Martina and M{\"u}ller, Michael}, title = {ChemInform Abstract: Enantioselective synthesis of (S)-2-Hydroxypropanone derivatives by Benzoylformate Decarboxylase Catalyzed C—C Bond Formation}, series = {Cheminform}, volume = {Vol. 32}, journal = {Cheminform}, number = {Iss. 4}, issn = {1522-2667 (E-Journal); 0931-7597 (Print)}, pages = {Publ. online}, year = {2001}, language = {en} } @article{BaeckerRakowskiPoghossianetal.2013, author = {B{\"a}cker, Matthias and Rakowski, D. and Poghossian, Arshak and Biselli, Manfred and Wagner, Patrick and Sch{\"o}ning, Michael Josef}, title = {Chip-based amperometric enzyme sensor system for monitoring of bioprocesses by flow-injection analysis}, series = {Journal of Biotechnology}, volume = {163}, journal = {Journal of Biotechnology}, number = {4}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0168-1656}, doi = {10.1016/j.jbiotec.2012.03.014}, pages = {371 -- 376}, year = {2013}, abstract = {A microfluidic chip integrating amperometric enzyme sensors for the detection of glucose, glutamate and glutamine in cell-culture fermentation processes has been developed. The enzymes glucose oxidase, glutamate oxidase and glutaminase were immobilized by means of cross-linking with glutaraldehyde on platinum thin-film electrodes integrated within a microfluidic channel. The biosensor chip was coupled to a flow-injection analysis system for electrochemical characterization of the sensors. The sensors have been characterized in terms of sensitivity, linear working range and detection limit. The sensitivity evaluated from the respective peak areas was 1.47, 3.68 and 0.28 μAs/mM for the glucose, glutamate and glutamine sensor, respectively. The calibration curves were linear up to a concentration of 20 mM glucose and glutamine and up to 10 mM for glutamate. The lower detection limit amounted to be 0.05 mM for the glucose and glutamate sensor, respectively, and 0.1 mM for the glutamine sensor. Experiments in cell-culture medium have demonstrated a good correlation between the glutamate, glutamine and glucose concentrations measured with the chip-based biosensors in a differential-mode and the commercially available instrumentation. The obtained results demonstrate the feasibility of the realized microfluidic biosensor chip for monitoring of bioprocesses.}, language = {en} } @article{MolinnusHardtKaeveretal.2018, author = {Molinnus, Denise and Hardt, G. and K{\"a}ver, L. and Willenberg, H.S. and Kr{\"o}ger, J.-C. and Poghossian, Arshak and Keusgen, Michael and Sch{\"o}ning, Michael Josef}, title = {Chip-based biosensor for the detection of low adrenaline concentrations to support adrenal venous sampling}, series = {Sensor and Actuators B: Chemical}, volume = {272}, journal = {Sensor and Actuators B: Chemical}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0925-4005}, doi = {10.1016/j.snb.2018.05.136}, pages = {21 -- 27}, year = {2018}, abstract = {A chip-based amperometric biosensor referring on using the bioelectrocatalytical amplification principle for the detection of low adrenaline concentrations is presented. The adrenaline biosensor has been prepared by modification of a platinum thin-film electrode with an enzyme membrane containing the pyrroloquinoline quinone-dependent glucose dehydrogenase and glutaraldehyde. Measuring conditions such as temperature, pH value, and glucose concentration have been optimized to achieve a high sensitivity and a low detection limit of about 1 nM adrenaline measured in phosphate buffer at neutral pH value. The response of the biosensor to different catecholamines has also been proven. Long-term stability of the adrenaline biosensor has been studied over 10 days. In addition, the biosensor has been successfully applied for adrenaline detection in human blood plasma for future biomedical applications. Furthermore, preliminary experiments have been carried to detect the adrenaline-concentration difference measured in peripheral blood and adrenal venous blood, representing the adrenal vein sampling procedure of a physician.}, language = {en} } @article{KuropkaMuellerHoeckeretal.1989, author = {Kuropka, Rolf and M{\"u}ller, Bettina and H{\"o}cker, Hartwig and Berndt, Heinz}, title = {Chiral stationary phases via hydrosilylation reaction of N-acryloylamino acids : I. Stationary phase with one chiral centre for high-performance liquid chromatography and development of a new derivatization pattern for amino acid enantiomers}, series = {Journal of chromatography A}, journal = {Journal of chromatography A}, number = {481}, isbn = {0021-9673}, pages = {380 -- 386}, year = {1989}, language = {en} } @article{ArtmannHueckHollwegetal.2000, author = {Artmann, Gerhard and Hueck, I. S. and Hollweg, H. G. and Schmid-Sch{\"o}nbein, G. W.}, title = {Chlorpromazine modulates the Morphological Macro- and Microstructure of Endothelial Cells. Hueck, I. S.; Hollweg, H. G.; Schmid-Sch{\"o}nbein, G. W.; Artmann, Gerhard Michael}, series = {American Journal of Physiology. Cell Physiology. 278 (2000), H. 5}, journal = {American Journal of Physiology. Cell Physiology. 278 (2000), H. 5}, isbn = {1522-1563}, pages = {873 -- 878}, year = {2000}, language = {en} } @inproceedings{AlexopoulosHoffschmidtRauetal.2011, author = {Alexopoulos, Spiros and Hoffschmidt, Bernhard and Rau, Christoph and Sattler, Johannes, Christoph}, title = {Choice of solar share of a hybrid power plant of a central receiver system and a biogas plant in dependency of the geographical latitude}, series = {World Renewable Energy Congress-Sweden : 8 -13 May, 2011, Link{\"o}ping, Sweden / ed.: Bahram Moshfegh}, booktitle = {World Renewable Energy Congress-Sweden : 8 -13 May, 2011, Link{\"o}ping, Sweden / ed.: Bahram Moshfegh}, publisher = {Univ. Electronic Pr.}, address = {Link{\"o}ping}, isbn = {9789173930703}, pages = {3710 -- 3717}, year = {2011}, language = {en} } @article{SchoeningBrinkmannRolkaetal.2005, author = {Sch{\"o}ning, Michael Josef and Brinkmann, D. and Rolka, David and Demuth, C. and Poghossian, Arshak}, title = {CIP (cleaning-in-place) suitable "non-glass" pH sensor based on a Ta2O5-gate EIS structure}, series = {Sensors and Actuators B: Chemical. 111-112 (2005)}, journal = {Sensors and Actuators B: Chemical. 111-112 (2005)}, isbn = {0925-4005}, pages = {423 -- 429}, year = {2005}, language = {en} } @article{SchoeningBrinkmannDemuthetal.2004, author = {Sch{\"o}ning, Michael Josef and Brinkmann, D. and Demuth, C. and Poghossian, Arshak}, title = {CIP (cleaning-in-place)-suitable „non-glass" pH sensor based on a Ta2O5-gate EIS structure}, series = {Digest of technical papers : September 12 - 15, 2004, Rome, Italy, Pontificia Universitas Sancto Thoma Aquinate in Urbe / [conference chairperson: C. Di Natale].}, journal = {Digest of technical papers : September 12 - 15, 2004, Rome, Italy, Pontificia Universitas Sancto Thoma Aquinate in Urbe / [conference chairperson: C. Di Natale].}, address = {Roma}, isbn = {88-7621-282-5}, pages = {857 -- 860}, year = {2004}, language = {en} } @article{ArtmannBurnsCanavesetal.2004, author = {Artmann, Gerhard and Burns, Laura and Canaves, Jaume M. and Temiz Artmann, Ayseg{\"u}l}, title = {Circular dichroism spectra of human hemoglobin reveal a reversible structural transition at body temperature}, series = {European Biophysics Journal. 33 (2004), H. 6}, journal = {European Biophysics Journal. 33 (2004), H. 6}, isbn = {1432-1017}, pages = {490 -- 496}, year = {2004}, language = {en} } @article{WollbrinkMasloZimmeretal.2020, author = {Wollbrink, Moritz and Maslo, Semir and Zimmer, Daniel and Abbas, Karim and Arntz, Kristian and Bergs, Thomas}, title = {Clamping and substrate plate system for continuous additive build-up and post-processing of metal parts}, series = {Procedia CIRP}, volume = {93}, journal = {Procedia CIRP}, publisher = {Elsevier}, address = {Amsterdam}, issn = {2212-8271}, doi = {10.1016/j.procir.2020.04.015}, pages = {108 -- 113}, year = {2020}, abstract = {The manufacturing share of laser powder bed fusion (L-PBF) increases in industrial application, but still many process steps are manually operated. Additionally, it is not possible to achieve tight dimensional tolerances or low surfaces roughness. Hence, a process chain has to be set up to combine additive manufacturing (AM) with further machining technologies. To achieve a continuous workpiece flow as basis for further industrialization of L-PBF, the paper presents a novel substrate system and its application on L-PBF machines and post-processing. The substrate system consists of a zero-point clamping system and a matrix-like interface of contact pins to be substantially connected to the workpiece within the L-PBF process.}, language = {en} } @article{StulpeBuschHellwig1993, author = {Stulpe, Werner and Busch, P. and Hellwig, K.-E.}, title = {Classical Representations of Finite-Dimensional Quantum Mechanics. Busch, P.; Hellwig, K.-E.; Stulpe, W.}, series = {International Journal of Theoretical Physics. 32 (1993), H. 3}, journal = {International Journal of Theoretical Physics. 32 (1993), H. 3}, isbn = {1572-9575}, pages = {399 -- 405}, year = {1993}, language = {en} } @book{Stulpe1997, author = {Stulpe, Werner}, title = {Classical Representations of Quantum Mechanics Related to Statistically Complete Observables}, publisher = {Wissenschaft und Technik Verl.}, address = {Berlin}, isbn = {3-89685-438-0}, pages = {117 S. : graph. Darst.}, year = {1997}, language = {en} } @article{GrotendorstEitrichKlessetal.2007, author = {Grotendorst, Johannes and Eitrich, T. and Kless, A. and Druska, C.}, title = {Classification of Highly Unbalanced CYP450 Data of Drugs Using Cost Sensitive Machine Learning Techniques / Eitrich, T. ; Kless, A. ; Druska, C. ; Meyer, W. ; Grotendorst J.}, series = {Journal of Chemical Information and Modeling. 47 (2007), H. 1}, journal = {Journal of Chemical Information and Modeling. 47 (2007), H. 1}, isbn = {1549-9596}, pages = {92 -- 103}, year = {2007}, language = {en} } @incollection{DachwaldUlamecBiele2013, author = {Dachwald, Bernd and Ulamec, Stephan and Biele, Jens}, title = {Clean in situ subsurface exploration of icy environments in the solar system}, series = {Habitability of other planets and satellites. - (Cellular origin, life in extreme habitats and astrobiology ; 28)}, booktitle = {Habitability of other planets and satellites. - (Cellular origin, life in extreme habitats and astrobiology ; 28)}, publisher = {Springer}, address = {Dordrecht}, isbn = {978-94-007-6545-0 (Druckausgabe)}, pages = {367 -- 397}, year = {2013}, abstract = {"To assess the habitability of the icy environments in the solar system, for example, on Mars, Europa, and Enceladus, the scientific analysis of material embedded in or underneath their ice layers is very important. We consider self-steering robotic ice melting probes to be the best method to cleanly access these environments, that is, in compliance with planetary protection standards. The required technologies are currently developed and tested."}, language = {en} } @inproceedings{BlankeDringVonteinetal.2018, author = {Blanke, Tobias and Dring, Bernd and Vontein, Marius and Kuhnhenne, Markus}, title = {Climate Change Mitigation Potentials of Vertical Building Integrated Photovoltaic}, series = {8th International Workshop on Integration of Solar Power into Power Systems : 16-17 October 2018, Stockholm, Sweden}, booktitle = {8th International Workshop on Integration of Solar Power into Power Systems : 16-17 October 2018, Stockholm, Sweden}, pages = {1 -- 7}, year = {2018}, language = {en} } @article{BehnamBeckerWeber2011, author = {Behnam, S. and Becker, A. and Weber, Hans-Joachim}, title = {Clinical benefit and cost-efficiency of minimized perfusion circuits for extracorporeal circulation during cardiac surgery}, series = {Zeitschrift f{\"u}r Herz-, Thorax- und Gef{\"a}ßchirurgie}, volume = {25}, journal = {Zeitschrift f{\"u}r Herz-, Thorax- und Gef{\"a}ßchirurgie}, number = {5}, publisher = {Springer}, address = {Berlin}, issn = {0930-9225}, pages = {305 -- 306}, year = {2011}, language = {en} } @article{ZhangHeimbachScheeretal.2016, author = {Zhang, Jin and Heimbach, Tycho and Scheer, Nico and Barve, Avantika and Li, Wenkui and Lin, Wen and He, Handan}, title = {Clinical Exposure Boost Predictions by Integrating Cytochrome P450 3A4-Humanized Mouse Studies With PBPK Modeling}, series = {Journal of Pharmaceutical Sciences}, volume = {Volume 105}, journal = {Journal of Pharmaceutical Sciences}, number = {Issue 4}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0022-3549}, doi = {doi.org/10.1016/j.xphs.2016.01.021}, pages = {1398 -- 1404}, year = {2016}, abstract = {NVS123 is a poorly water-soluble protease 56 inhibitor in clinical development. Data from in vitro hepatocyte studies suggested that NVS123 is mainly metabolized by CYP3A4. As a consequence of limited solubility, NVS123 therapeutic plasma exposures could not be achieved even with high doses and optimized formulations. One approach to overcome NVS123 developability issues was to increase plasma exposure by coadministrating it with an inhibitor of CYP3A4 such as ritonavir. A clinical boost effect was predicted by using physiologically based pharmacokinetic (PBPK) modeling. However, initial boost predictions lacked sufficient confidence because a key parameter, fraction of drug metabolized by CYP3A4 (ƒₘCYP3A4), could not be estimated with accuracy on account of disconnects between in vitro and in vivo preclinical data. To accurately estimate ƒₘCYP3A4 in human, an in vivo boost effect study was conducted using CYP3A4-humanized mouse model which showed a 33- to 56-fold exposure boost effect. Using a top-down approach, human ƒₘCYP3A4 for NVS123 was estimated to be very high and included in the human PBPK modeling to support subsequent clinical study design. The combined use of the in vivo boost study in CYP3A4-humanized mouse model mice along with PBPK modeling accurately predicted the clinical outcome and identified a significant NVS123 exposure boost (∼42-fold increase) with ritonavir.}, language = {en} } @article{MeyerGranrathFeyerletal.2021, author = {Meyer, Max-Arno and Granrath, Christian and Feyerl, G{\"u}nter and Richenhagen, Johannes and Kaths, Jakob and Andert, Jakob}, title = {Closed-loop platoon simulation with cooperative intelligent transportation systems based on vehicle-to-X communication}, series = {Simulation Modelling Practice and Theory}, volume = {106}, journal = {Simulation Modelling Practice and Theory}, number = {Art. 102173}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1569-190X}, doi = {10.1016/j.simpat.2020.102173}, year = {2021}, language = {en} } @article{SiepmannRupietta1993, author = {Siepmann, Thomas and Rupietta, D.}, title = {Closer to the customer with computerized product support}, series = {Technische Mitteilungen Krupp (1993)}, journal = {Technische Mitteilungen Krupp (1993)}, address = {Essen}, year = {1993}, language = {en} }