@article{SchrothSchoeningKordosetal.1999, author = {Schroth, P. and Sch{\"o}ning, Michael Josef and Kordos, P. and L{\"u}th, H. and Sch{\"u}tz, S. and Weißbecker, B. and Hummel, Hans E.}, title = {Insectbased BioFETs with improved signal characteristics}, series = {Biosensors \& Bioelectronics. 14 (1999), H. 3}, journal = {Biosensors \& Bioelectronics. 14 (1999), H. 3}, issn = {0956-5663}, pages = {303 -- 308}, year = {1999}, language = {en} } @article{SchuetzCzynskiHummeletal.2000, author = {Sch{\"u}tz, S. and Czynski, J. and Hummel, Hans E. and Sch{\"o}ning, Michael Josef and Schroth, P. and Kordos, P. and L{\"u}th, H.}, title = {Insect meets microelectronics: A BioFET as a first step to bioelectronic microsystems}, series = {Transducers '99 : proceedings of the Tenth International Conference on Solid-State Sensors and Actuators ; 7 - 10 June, 1999, Sendai, Japan / ed.: S. Middelhoek}, journal = {Transducers '99 : proceedings of the Tenth International Conference on Solid-State Sensors and Actuators ; 7 - 10 June, 1999, Sendai, Japan / ed.: S. Middelhoek}, publisher = {Elsevier}, address = {Amsterdam [u.a.]}, pages = {1104 -- 1107}, year = {2000}, language = {en} } @article{SchoeningSchrothLuethetal.2001, author = {Sch{\"o}ning, Michael Josef and Schroth, Peter and L{\"u}th, Hans and Hummel, Hans E. and Sch{\"u}tz, Stefan}, title = {Insect chemoreceptors coupled to silicon transistors as innovative biosensors}, series = {Proceedings of SPIE. 4205 (2001)}, journal = {Proceedings of SPIE. 4205 (2001)}, pages = {152 -- 162}, year = {2001}, language = {en} } @article{KloockMourzinaErmolenkoetal.2004, author = {Kloock, Joachim P. and Mourzina, Y.G. and Ermolenko, Y. and Doll, T. and Schubert, J. and Sch{\"o}ning, Michael Josef}, title = {Inorganic thin-film sensor membranes with PLD-prepared chalcogenide glasses: Challenges and implementation}, series = {Sensors. 4 (2004), H. 10}, journal = {Sensors. 4 (2004), H. 10}, isbn = {1424-8220}, pages = {156 -- 162}, year = {2004}, language = {en} } @article{SchoeningSchubertKloocketal.2002, author = {Sch{\"o}ning, Michael Josef and Schubert, J and Kloock, Joachim P. and Zander, W. and Mourzina, Y. G. and Legin, A. and Vlasov, Y. G. and L{\"u}th, H.}, title = {Innovative thin film techniques for microfabricating electrochemical sensors}, series = {Lecture Notes of the ICB Seminars}, journal = {Lecture Notes of the ICB Seminars}, publisher = {MCB}, address = {Warsaw}, pages = {55 -- 66}, year = {2002}, language = {en} } @article{SchoeningSchubertKloocketal.2001, author = {Sch{\"o}ning, Michael Josef and Schubert, Joachim P. and Kloock, Joachim P. and Zander, W. and Mourzina, Y. G. and Legin, A. and Vlasov, Y. G. and L{\"u}th, H.}, title = {Innovative thin film techniques for microfabricating electrochemical sensors}, series = {Biocybernetics and Biomedical Engineering. 21 (2001), H. 4}, journal = {Biocybernetics and Biomedical Engineering. 21 (2001), H. 4}, isbn = {0208-5216}, pages = {107 -- 119}, year = {2001}, language = {en} } @article{HamadBilattoAdlyetal.2016, author = {Hamad, E. M. and Bilatto, S. E. R. and Adly, N. Y. and Correa, D. S. and Wolfrum, B. and Sch{\"o}ning, Michael Josef and Offenh{\"a}usser, A. and Yakushenko, A.}, title = {Inkjet printing of UV-curable adhesive and dielectric inks for microfluidic devices}, series = {Lab on a Chip}, volume = {16}, journal = {Lab on a Chip}, number = {1}, publisher = {Royal Society of Chemistry}, address = {Cambridge}, issn = {1473-0189}, doi = {10.1039/C5LC01195G}, pages = {70 -- 74}, year = {2016}, abstract = {Bonding of polymer-based microfluidics to polymer substrates still poses a challenge for Lab-On-a-Chip applications. Especially, when sensing elements are incorporated, patterned deposition of adhesives with curing at ambient conditions is required. Here, we demonstrate a fabrication method for fully printed microfluidic systems with sensing elements using inkjet and stereolithographic 3D-printing.}, language = {en} } @article{BertzSchoeningMolinnusetal.2024, author = {Bertz, Morten and Sch{\"o}ning, Michael Josef and Molinnus, Denise and Homma, Takayuki}, title = {Influence of temperature, light, and H₂O₂ concentration on microbial spore inactivation: in-situ Raman spectroscopy combined with optical trapping}, series = {Physica status solidi (a) applications and materials science}, journal = {Physica status solidi (a) applications and materials science}, number = {Early View}, publisher = {Wiley-VCH}, address = {Berlin}, issn = {1862-6319 (Online)}, doi = {10.1002/pssa.202300866}, pages = {8 Seiten}, year = {2024}, abstract = {To gain insight on chemical sterilization processes, the influence of temperature (up to 70 °C), intense green light, and hydrogen peroxide (H₂O₂) concentration (up to 30\% in aqueous solution) on microbial spore inactivation is evaluated by in-situ Raman spectroscopy with an optical trap. Bacillus atrophaeus is utilized as a model organism. Individual spores are isolated and their chemical makeup is monitored under dynamically changing conditions (temperature, light, and H₂O₂ concentration) to mimic industrially relevant process parameters for sterilization in the field of aseptic food processing. While isolated spores in water are highly stable, even at elevated temperatures of 70 °C, exposure to H₂O₂ leads to a loss of spore integrity characterized by the release of the key spore biomarker dipicolinic acid (DPA) in a concentration-dependent manner, which indicates damage to the inner membrane of the spore. Intensive light or heat, both of which accelerate the decomposition of H₂O₂ into reactive oxygen species (ROS), drastically shorten the spore lifetime, suggesting the formation of ROS as a rate-limiting step during sterilization. It is concluded that Raman spectroscopy can deliver mechanistic insight into the mode of action of H₂O₂-based sterilization and reveal the individual contributions of different sterilization methods acting in tandem.}, language = {en} } @article{JanusAchtsnichtTempeletal.2023, author = {Janus, Kevin Alexander and Achtsnicht, Stefan and Tempel, Laura and Drinic, Aleksaner and Kopp, Alexander and Keusgen, Michael and Sch{\"o}ning, Michael Josef}, title = {Influence of fibroin membrane composition and curing parameters on the performance of a biodegradable enzymatic biosensor manufactured from Silicon-Free Carbon}, series = {Physica status solidi : pss. A, Applications and materials science}, volume = {220}, journal = {Physica status solidi : pss. A, Applications and materials science}, number = {22}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1862-6300 (Print)}, doi = {10.1002/pssa.202300081}, pages = {Artikel 2300081}, year = {2023}, abstract = {Herein, fibroin, polylactide (PLA), and carbon are investigated for their suitability as biocompatible and biodegradable materials for amperometric biosensors. For this purpose, screen-printed carbon electrodes on the biodegradable substrates fibroin and PLA are modified with a glucose oxidase membrane and then encapsulated with the biocompatible material Ecoflex. The influence of different curing parameters of the carbon electrodes on the resulting biosensor characteristics is studied. The morphology of the electrodes is investigated by scanning electron microscopy, and the biosensor performance is examined by amperometric measurements of glucose (0.5-10 mM) in phosphate buffer solution, pH 7.4, at an applied potential of 1.2 V versus a Ag/AgCl reference electrode. Instead of Ecoflex, fibroin, PLA, and wound adhesive are tested as alternative encapsulation compounds: a series of swelling tests with different fibroin compositions, PLA, and Ecoflex has been performed before characterizing the most promising candidates by chronoamperometry. Therefore, the carbon electrodes are completely covered with the particular encapsulation material. Chronoamperometric measurements with H2O2 concentrations between 0.5 and 10 mM enable studying the leakage current behavior.}, language = {en} } @article{SiqueiraMolinnusBegingetal.2014, author = {Siqueira, Jose R. and Molinnus, Denise and Beging, Stefan and Sch{\"o}ning, Michael Josef}, title = {Incorporating a hybrid urease-carbon nanotubes sensitive nanofilm on capacitive field-effect sensors for urea detection}, series = {Analytical chemistry}, volume = {86}, journal = {Analytical chemistry}, number = {11}, publisher = {ACS Publications}, address = {Columbus}, issn = {1520-6882 (E-Journal); 0003-2700 (Print); 0096-4484 (Print)}, doi = {10.1021/ac500458s}, pages = {5370 -- 5375}, year = {2014}, abstract = {The ideal combination among biomolecules and nanomaterials is the key for reaching biosensing units with high sensitivity. The challenge, however, is to find out a stable and sensitive film architecture that can be incorporated on the sensor's surface. In this paper, we report on the benefits of incorporating a layer-by-layer (LbL) nanofilm of polyamidoamine (PAMAM) dendrimer and carbon nanotubes (CNTs) on capacitive electrolyte-insulator-semiconductor (EIS) field-effect sensors for detecting urea. Three sensor arrangements were studied in order to investigate the adequate film architecture, involving the LbL film with the enzyme urease: (i) urease immobilized directly onto a bare EIS [EIS-urease] sensor; (ii) urease atop the LbL film over the EIS [EIS-(PAMAM/CNT)-urease] sensor; and (iii) urease sandwiched between the LbL film and another CNT layer [EIS-(PAMAM/CNT)-urease-CNT]. The surface morphology of all three urea-based EIS biosensors was investigated by atomic force microscopy (AFM), while the biosensing abilities were studied by means of capacitance-voltage (C/V) and dynamic constant-capacitance (ConCap) measureaments at urea concentrations ranging from 0.1 mM to 100 mM. The EIS-urease and EIS-(PAMAM/CNT)-urease sensors showed similar sensitivity (∼18 mV/decade) and a nonregular signal behavior as the urea concentration increased. On the other hand, the EIS-(PAMAM/CNT)-urease-CNT sensor exhibited a superior output signal performance and higher sensitivity of about 33 mV/decade. The presence of the additional CNT layer was decisive to achieve a urea based EIS sensor with enhanced properties. Such sensitive architecture demonstrates that the incorporation of an adequate hybrid enzyme-nanofilm as sensing unit opens new prospects for biosensing applications using the field-effect sensor platform.}, language = {en} } @article{ThustSchrothToepleretal.1998, author = {Thust, M. and Schroth, P. and T{\"o}pler, A. and Sch{\"o}ning, Michael Josef and M{\"u}ller-Veggian, Mattea and Kordos, P. and L{\"u}th, H.}, title = {Improving the detection limit of a capacitive sensor by means of a diffusion barrier}, series = {Eurosensors XII : proceedings of the 12th European Conference on Solid-State Transducers and the 9th UK Conference on Sensors and their Applications, Southampton, UK, 13 - 16 September 1998 / ed. by N. M. White ; Vol. 1}, journal = {Eurosensors XII : proceedings of the 12th European Conference on Solid-State Transducers and the 9th UK Conference on Sensors and their Applications, Southampton, UK, 13 - 16 September 1998 / ed. by N. M. White ; Vol. 1}, publisher = {Inst. of Physics Publ.}, address = {Bristol [u.a.]}, isbn = {0-7503-0595-9}, pages = {507 -- 510}, year = {1998}, language = {en} } @article{SchrothSchoeningSchuetzetal.1999, author = {Schroth, P. and Sch{\"o}ning, Michael Josef and Sch{\"u}tz, S. and Epanya, P. and Steffen, A. and Weißbecker, B. and Hummel, Hans E. and Kordos, P. and L{\"u}th, H.}, title = {Improving the bioelectronic interface of an antenna/chip biosensor - technological aspects}, series = {Proceedings : The Hague, The Netherlands, September 12 - 15, 1999 / [ed. by M. Bartek]. Vol 1.}, journal = {Proceedings : The Hague, The Netherlands, September 12 - 15, 1999 / [ed. by M. Bartek]. Vol 1.}, address = {The Hague, The Netherlands}, isbn = {90-76699-02-X}, pages = {569 -- 572}, year = {1999}, language = {en} } @article{MiyamotoSekiSutoetal.2018, author = {Miyamoto, Koichiro and Seki, Kosuke and Suto, Takeyuki and Werner, Frederik and Wagner, Torsten and Sch{\"o}ning, Michael Josef and Yoshinobu, Tatsuo}, title = {Improved spatial resolution of the chemical imaging sensor with a hybrid illumination that suppresses lateral diffusion of photocarriers}, series = {Sensor and Actuators B: Chemical}, volume = {273}, journal = {Sensor and Actuators B: Chemical}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0925-4005}, doi = {10.1016/j.snb.2018.07.016}, pages = {1328 -- 1333}, year = {2018}, abstract = {The chemical imaging sensor is a semiconductor-based chemical sensor capable of visualizing pH and ion distributions. The spatial resolution depends on the lateral diffusion of photocarriers generated by illumination of the semiconductor substrate. In this study, two types of optical setups, one based on a bundle of optical fibers and the other based on a binocular tube head, were developed to project a hybrid illumination of a modulated light beam and a ring-shaped constant illumination onto the sensor plate. An improved spatial resolution was realized by the ring-shaped constant illumination, which suppressed lateral diffusion of photocarriers by enhanced recombination due to the increased carrier concentration.}, language = {en} } @article{DelleHuckBaeckeretal.2015, author = {Delle, Lotta E. and Huck, Christina and B{\"a}cker, Matthias and M{\"u}ller, Frank and Grandthyll, Samuel and Jacobs, Karin and Lilischkis, Rainer and Vu, Xuan T. and Sch{\"o}ning, Michael Josef and Wagner, Patrick and Thoelen, Roland and Weil, Maryam and Ingebrandt, Sven}, title = {Impedimetric immunosensor for the detection of histamine based on reduced graphene oxide}, series = {Physica status solidi (a)}, volume = {212}, journal = {Physica status solidi (a)}, number = {6}, publisher = {Wiley}, address = {Weinheim}, issn = {1862-6319}, doi = {10.1002/pssa.201431863}, pages = {1327 -- 1334}, year = {2015}, language = {en} } @article{RiedelKartchemnikSchoeningetal.2014, author = {Riedel, Marc and Kartchemnik, Julia and Sch{\"o}ning, Michael Josef and Lisdat, Fred}, title = {Impedimetric DNA detection - steps forward to sensorial application}, series = {Analytical chemistry}, volume = {86 (2014)}, journal = {Analytical chemistry}, number = {15}, publisher = {ACS Publications}, address = {Columbus}, issn = {1520-6882 (E-Journal); 0003-2700 (Print); 0096-4484 (Print)}, doi = {10.1021/ac501800q}, pages = {7867 -- 7874}, year = {2014}, abstract = {This study describes a label-free impedimetric sensor based on short ssDNA recognition elements for the detection of hybridization events. We concentrate on the elucidation of the influence of target length and recognition sequence position on the sensorial performance. The impedimetric measurements are performed in the presence of the redox system ferri-/ferrocyanide and show an increase in charge transfer resistance upon hybridization of ssDNA to the sensor surface. Investigations on the impedimetric signal stability demonstrate a clear influence of the buffers used during the sensor preparation and the choice of the passivating mercaptoalcanol compound. A stable sensor system has been developed, enabling a reproducible detection of 25mer target DNA in the low nanomolar range. After hybridization, a sensor regeneration can be reached with deionized water by adjustment of effective convection conditions, ensuring a sensor reusability. By investigations of longer targets with overhangs exposed to the solution, we can demonstrate applicability of the impedimetric detection for longer ssDNA. However, a decreasing charge transfer resistance change (ΔRct) is found by extending the overhang. As a strategy to increase the impedance change for longer target strands, the position of the recognition sequence can be designed in a way that a small overhang is exposed to the electrode surface. This is found to result in an increase in the relative Rct change. These results suggest that DNA and consequently negative charge near the electrode possess a larger impact on the impedimetric signal than DNA further away.}, language = {en} } @inproceedings{OberlaenderArreolaHansenetal.2017, author = {Oberl{\"a}nder, Jan and Arreola, Julio and Hansen, Christina and Greeff, Anton and Mayer, Marlena and Keusgen, Michael and Sch{\"o}ning, Michael Josef}, title = {Impedimetric Biosensor to Enable Fast Evaluation of Gaseous Sterilization Processes}, series = {MDPI Proceedings}, volume = {1}, booktitle = {MDPI Proceedings}, number = {4}, doi = {10.3390/proceedings1040435}, pages = {4 Seiten}, year = {2017}, language = {en} } @article{SchusserLeinhosBaeckeretal.2013, author = {Schusser, Sebastian and Leinhos, Marcel and B{\"a}cker, Matthias and Poghossian, Arshak and Wagner, Patrick and Sch{\"o}ning, Michael Josef}, title = {Impedance spectroscopy: A tool for real-time in situ monitoring of the degradation of biopolymers}, series = {Physica Status Solidi (A)}, volume = {210}, journal = {Physica Status Solidi (A)}, number = {5}, publisher = {Wiley}, address = {Weinheim}, issn = {1521-396X ; 0031-8965}, doi = {10.1002/pssa.201200941}, pages = {905 -- 910}, year = {2013}, abstract = {Investigation of the degradation kinetics of biodegradable polymers is essential for the development of implantable biomedical devices with predicted biodegradability. In this work, an impedimetric sensor has been applied for real-time and in situ monitoring of degradation processes of biopolymers. The sensor consists of two platinum thin-film electrodes covered by a polymer film to be studied. The benchmark biomedical polymer poly(D,L-lactic acid) (PDLLA) was used as a model system. PDLLA films were deposited on the sensor structure from a polymer solution by using the spin-coating method. The degradation kinetics of PDLLA films have been studied in alkaline solutions of pH 9 and 12 by means of an impedance spectroscopy (IS) method. Any changes in a polymer capacitance/resistance induced by water uptake and/or polymer degradation will modulate the global impedance of the polymer-covered sensor that can be used as an indicator of the polymer degradation. The degradation rate can be evaluated from the time-dependent impedance spectra. As expected, a faster degradation has been observed for PDLLA films exposed to pH 12 solution.}, language = {en} } @article{PoghossianMaiMourzinaetal.2004, author = {Poghossian, Arshak and Mai, D.-T. and Mourzina, Y. and Sch{\"o}ning, Michael Josef}, title = {Impedance effect of an ion-sensitive membrane: characterisation of an EMIS sensor by impedance spectroscopy, capacitance-voltage and constant-capacitance method}, series = {Sensors and Actuators B. 103 (2004), H. 1-2}, journal = {Sensors and Actuators B. 103 (2004), H. 1-2}, isbn = {0925-4005}, pages = {423 -- 428}, year = {2004}, language = {en} } @article{MourzinaYoshinobuErmolenkoetal.2004, author = {Mourzina, Ioulia G. and Yoshinobu, Tatsuo and Ermolenko, Yuri E. and Vlasov, Yuri G. and Sch{\"o}ning, Michael Josef and Iwasaki, H.}, title = {Immobilization of urease and cholinesterase on the surface of semiconductor transducer for the development of lightaddressable potentiometric sensors}, series = {Microchimica Acta. 144 (2004), H. 1-3}, journal = {Microchimica Acta. 144 (2004), H. 1-3}, isbn = {0026-3672}, pages = {41 -- 50}, year = {2004}, language = {en} } @article{MourzinaYoshinobuErmolenkoetal.2004, author = {Mourzina, I.G. and Yoshinobu, T. and Ermolenko, Y.E. and Vlasov, Y. G. and Sch{\"o}ning, Michael Josef and Iwasaki, H.}, title = {Immobilization of urease and cholinesterase on the surface of semiconductor transducer for the development of light-addressable potentiometric sensors}, series = {Technical digest of the 10th International Meeting on Chemical Sensors, July 11 - 14, 2004, Tsukuba, Japan / Japan Association of Chemical Sensors}, journal = {Technical digest of the 10th International Meeting on Chemical Sensors, July 11 - 14, 2004, Tsukuba, Japan / Japan Association of Chemical Sensors}, publisher = {Japan Association of Chemical Sensors}, address = {Fukuoka}, pages = {788 -- 789}, year = {2004}, language = {en} }