@article{PoghossianAbouzarAmbergeretal.2007,
  author    = {Poghossian, Arshak and Abouzar, Maryam H. and Amberger, F. and Mayer, D. and Han, Y. and Ingebrandt, S. and Offenh{\"a}usser, A. and Sch{\"o}ning, Michael Josef},
  title     = {Field-effect sensors with charged macromolecules: Characterisation by capacitance-voltage, constant-capacitance, impedance spectroscopy and atomic-force microscopy methods},
  series = {Biosensors and Bioelectronics. 22 (2007), H. 9-10},
  journal   = {Biosensors and Bioelectronics. 22 (2007), H. 9-10},
  isbn      = {0956-5663},
  pages     = {2100 -- 2107},
  year      = {2007},
  language  = {en}
}
@inproceedings{PoghossianIngebrandtPlatenetal.2006,
  author    = {Poghossian, Arshak and Ingebrandt, S. and Platen, J. and Sch{\"o}ning, Michael Josef},
  title     = {Field-effect sensors with charged macromolecules - from micro towards nano aspects},
  series = {Biochemical Sensing Utilisation of Micro-and Nanotechnologies, Warschau, Nov. 2005 : Lecture Notes of the ICB Seminar / ed.: M. Mascini, W. Torbicz},
  booktitle = {Biochemical Sensing Utilisation of Micro-and Nanotechnologies, Warschau, Nov. 2005 : Lecture Notes of the ICB Seminar / ed.: M. Mascini, W. Torbicz},
  publisher = {Polish Academy Sciences Press},
  address   = {Warsaw},
  pages     = {74 -- 81},
  year      = {2006},
  language  = {en}
}
@article{PoghossianJablonskiMolinnusetal.2020,
  author    = {Poghossian, Arshak and Jablonski, Melanie and Molinnus, Denise and Wege, Christina and Sch{\"o}ning, Michael Josef},
  title     = {Field-Effect Sensors for Virus Detection: From Ebola to SARS-CoV-2 and Plant Viral Enhancers},
  series = {Frontiers in Plant Science},
  volume    = {11},
  journal   = {Frontiers in Plant Science},
  number    = {Article 598103},
  publisher = {Frontiers},
  address   = {Lausanne},
  doi       = {10.3389/fpls.2020.598103},
  pages     = {1 -- 14},
  year      = {2020},
  abstract  = {Coronavirus disease 2019 (COVID-19) is a novel human infectious disease provoked by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Currently, no specific vaccines or drugs against COVID-19 are available. Therefore, early diagnosis and treatment are essential in order to slow the virus spread and to contain the disease outbreak. Hence, new diagnostic tests and devices for virus detection in clinical samples that are faster, more accurate and reliable, easier and cost-efficient than existing ones are needed. Due to the small sizes, fast response time, label-free operation without the need for expensive and time-consuming labeling steps, the possibility of real-time and multiplexed measurements, robustness and portability (point-of-care and on-site testing), biosensors based on semiconductor field-effect devices (FEDs) are one of the most attractive platforms for an electrical detection of charged biomolecules and bioparticles by their intrinsic charge. In this review, recent advances and key developments in the field of label-free detection of viruses (including plant viruses) with various types of FEDs are presented. In recent years, however, certain plant viruses have also attracted additional interest for biosensor layouts: Their repetitive protein subunits arranged at nanometric spacing can be employed for coupling functional molecules. If used as adapters on sensor chip surfaces, they allow an efficient immobilization of analyte-specific recognition and detector elements such as antibodies and enzymes at highest surface densities. The display on plant viral bionanoparticles may also lead to long-time stabilization of sensor molecules upon repeated uses and has the potential to increase sensor performance substantially, compared to conventional layouts. This has been demonstrated in different proof-of-concept biosensor devices. Therefore, richly available plant viral particles, non-pathogenic for animals or humans, might gain novel importance if applied in receptor layers of FEDs. These perspectives are explained and discussed with regard to future detection strategies for COVID-19 and related viral diseases.},
  language  = {en}
}
@article{PoghossianAbouzarSakkarietal.2006,
  author    = {Poghossian, Arshak and Abouzar, Maryam H. and Sakkari, M. and Kassab, T. and Han, Y. and Ingebrandt, S. and Offenh{\"a}usser, A. and Sch{\"o}ning, Michael Josef},
  title     = {Field-effect sensors for monitoring the layer-by-layer adsorption of charged macromolecules},
  series = {Sensors and Actuators B: Chemical. 118 (2006), H. 1-2},
  journal   = {Sensors and Actuators B: Chemical. 118 (2006), H. 1-2},
  isbn      = {0925-4005},
  pages     = {163 -- 170},
  year      = {2006},
  language  = {en}
}
@article{AbouzarIngebrandtPoghossianetal.2009,
  author    = {Abouzar, Maryam H. and Ingebrandt, S. and Poghossian, Arshak and Zhang, Y. and Moritz, W. and Sch{\"o}ning, Michael Josef},
  title     = {Field-effect nanoplate capacitive pH sensor based on SOI structure},
  series = {Semiconductor micro- and nanoelectronics : Proceedings of the Seventh International Conference , Tsakhcadzor, Armenia July 3-5 2009},
  journal   = {Semiconductor micro- and nanoelectronics : Proceedings of the Seventh International Conference , Tsakhcadzor, Armenia July 3-5 2009},
  pages     = {55 -- 58},
  year      = {2009},
  language  = {en}
}
@article{GunSchoeningAbouzaretal.2008,
  author    = {Gun, Jenny and Sch{\"o}ning, Michael Josef and Abouzar, Maryam H. and Poghossian, Arshak and Katz, Evgeny},
  title     = {Field-Effect Nanoparticle-Based Glucose Sensor on a Chip: Amplification Effect of Coimmobilized Redox Species},
  series = {Electroanalysis. 20 (2008), H. 16},
  journal   = {Electroanalysis. 20 (2008), H. 16},
  isbn      = {1521-4109},
  pages     = {1748 -- 1753},
  year      = {2008},
  language  = {en}
}
@article{PoghossianWeilBaeckeretal.2012,
  author    = {Poghossian, Arshak and Weil, M. H. and B{\"a}cker, Matthias and Mayer, D. and Sch{\"o}ning, Michael Josef},
  title     = {Field-effect Devices Functionalised with Gold-Nanoparticle/Macromolecule Hybrids: New Opportunities for a Label-Free Biosensing},
  series = {Procedia Engineering},
  journal   = {Procedia Engineering},
  number    = {47},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1877-7058},
  doi       = {10.1016/j.proeng.2012.09.136},
  pages     = {273 -- 276},
  year      = {2012},
  abstract  = {Field-effect capacitive electrolyte-insulator-semiconductor (EIS) sensors functionalised with citrate-capped gold nanoparticles (AuNP) have been used for the electrostatic detection of macromolecules by their intrinsic molecular charge. The EIS sensor detects the charge changes in the AuNP/macromolecule hybrids induced by the adsorption or binding events. A feasibility of the proposed detection scheme has been exemplary demonstrated by realising EIS sensors for the detection of poly-D-lysine molecules.},
  language  = {en}
}
@article{PoghossianIngebrandtOffenhaeusseretal.2009,
  author    = {Poghossian, Arshak and Ingebrandt, S. and Offenh{\"a}usser, A. and Sch{\"o}ning, Michael Josef},
  title     = {Field-effect devices for detecting cellular signals},
  series = {Seminars in Cell \& Developmental Biology. 20 (2009), H. 1},
  journal   = {Seminars in Cell \& Developmental Biology. 20 (2009), H. 1},
  publisher = {Elsevier},
  address   = {Amsterdam},
  isbn      = {1096-3634},
  pages     = {41 -- 48},
  year      = {2009},
  language  = {en}
}
@article{BegingMlynekHataihimakuletal.2010,
  author    = {Beging, Stefan and Mlynek, Daniela and Hataihimakul, Sudkanung and Poghossian, Arshak and Baldsiefen, Gerhard and Busch, Heinz and Laube, Norbert and Kleinen, Lisa and Sch{\"o}ning, Michael Josef},
  title     = {Field-effect calcium sensor for the determination of the risk of urinary stone formation},
  series = {Sensors and Actuators B: Chemical. 144 (2010), H. 2},
  journal   = {Sensors and Actuators B: Chemical. 144 (2010), H. 2},
  pages     = {374 -- 379},
  year      = {2010},
  language  = {en}
}
@inproceedings{JablonskiKochBronderetal.2017,
  author    = {Jablonski, Melanie and Koch, Claudia and Bronder, Thomas and Poghossian, Arshak and Wege, Christina and Sch{\"o}ning, Michael Josef},
  title     = {Field-Effect Biosensors Modified with Tobacco Mosaic Virus Nanotubes as Enzyme Nanocarrier},
  series = {MDPI Proceeding},
  volume    = {1},
  booktitle = {MDPI Proceeding},
  number    = {4},
  doi       = {10.3390/proceedings1040505},
  pages     = {4},
  year      = {2017},
  language  = {en}
}
@article{PoghossianJablonskiKochetal.2018,
  author    = {Poghossian, Arshak and Jablonski, Melanie and Koch, Claudia and Bronder, Thomas and Rolka, David and Wege, Christina and Sch{\"o}ning, Michael Josef},
  title     = {Field-effect biosensor using virus particles as scaffolds for enzyme immobilization},
  series = {Biosensors and Bioelectronics},
  volume    = {110},
  journal   = {Biosensors and Bioelectronics},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0956-5663},
  doi       = {10.1016/j.bios.2018.03.036},
  pages     = {168 -- 174},
  year      = {2018},
  abstract  = {A field-effect biosensor employing tobacco mosaic virus (TMV) particles as scaffolds for enzyme immobilization is presented. Nanotubular TMV scaffolds allow a dense immobilization of precisely positioned enzymes with retained activity. To demonstrate feasibility of this new strategy, a penicillin sensor has been developed by coupling a penicillinase with virus particles as a model system. The developed field-effect penicillin biosensor consists of an Al-p-Si-SiO₂-Ta₂O₅-TMV structure and has been electrochemically characterized in buffer solutions containing different concentrations of penicillin G. In addition, the morphology of the biosensor surface with virus particles was characterized by scanning electron microscopy and atomic force microscopy methods. The sensors possessed a high penicillin sensitivity of ~ 92 mV/dec in a nearly-linear range from 0.1 mM to 10 mM, and a low detection limit of about 50 µM. The long-term stability of the penicillin biosensor was periodically tested over a time period of about one year without any significant loss of sensitivity. The biosensor has also been successfully applied for penicillin detection in bovine milk samples.},
  language  = {en}
}
@article{SchoeningPoghossianSchultzeetal.2002,
  author    = {Sch{\"o}ning, Michael Josef and Poghossian, Arshak and Schultze, J. W. and L{\"u}th, H.},
  title     = {Field-effect based multifunctional hybrid sensor module for the determination of both (bio-)chemical and physical paramters},
  series = {Proceedings of SPIE. 4576 (2002)},
  journal   = {Proceedings of SPIE. 4576 (2002)},
  pages     = {149 -- 159},
  year      = {2002},
  language  = {en}
}
@article{AbouzarSchoeningPoghossianetal.2008,
  author    = {Abouzar, Maryam H. and Sch{\"o}ning, Michael Josef and Poghossian, Arshak and Christiaens, P. and Williams, O. A. and Wagner, P. and Haenen, K.},
  title     = {Feldeffektsensor auf nanokristalliner Diamantbasis},
  series = {Sensoren und Messsysteme 2008 : 14. Fachtagung Ludwigsburg, 11. und 12. M{\"a}rz 2008 / VDI/VDE-Gesellschaft Mess- und Automatisierungstechnik},
  journal   = {Sensoren und Messsysteme 2008 : 14. Fachtagung Ludwigsburg, 11. und 12. M{\"a}rz 2008 / VDI/VDE-Gesellschaft Mess- und Automatisierungstechnik},
  publisher = {VDI-Verl.},
  address   = {D{\"u}sseldorf},
  isbn      = {978-3-18-092011-5},
  pages     = {549 -- 558},
  year      = {2008},
  language  = {de}
}
@article{BegingPoghossianSchoeningetal.2008,
  author    = {Beging, Stefan and Poghossian, Arshak and Sch{\"o}ning, Michael Josef and Hataihimakul, Sudkanung and Busch, H. and Baldsiefen, G. and Laube, N. and Kleinen, L. and Hosseiny, R.},
  title     = {Feldeffektbasierender Ca2+-sensitiver Sensor f{\"u}r den Einsatz im Nativurin zur Bestimmung des Harnsteinbildungsrisikos},
  series = {Sensoren und Messsysteme 2008 : 14. Fachtagung Ludwigsburg, 11. und 12. M{\"a}rz 2008 / VDI/VDE-Gesellschaft Mess- und Automatisierungstechnik},
  journal   = {Sensoren und Messsysteme 2008 : 14. Fachtagung Ludwigsburg, 11. und 12. M{\"a}rz 2008 / VDI/VDE-Gesellschaft Mess- und Automatisierungstechnik},
  publisher = {VDI-Verl.},
  address   = {D{\"u}sseldorf},
  isbn      = {978-3-18-092011-5},
  pages     = {775 -- 782},
  year      = {2008},
  language  = {de}
}
@article{WendlandtKochBritzetal.2023,
  author    = {Wendlandt, Tim and Koch, Claudia and Britz, Beate and Liedek, Anke and Schmidt, Nora and Werner, Stefan and Gleba, Yuri and Vahidpour, Farnoosh and Welden, Melanie and Poghossian, Arshak and Sch{\"o}ning, Michael Josef},
  title     = {Facile Purification and Use of Tobamoviral Nanocarriers for Antibody-Mediated Display of a Two-Enzyme System},
  series = {Viruses},
  volume    = {9},
  journal   = {Viruses},
  number    = {15},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {1999-4915},
  doi       = {doi.org/10.3390/v15091951},
  pages     = {Artikel 1951},
  year      = {2023},
  abstract  = {Immunosorbent turnip vein clearing virus (TVCV) particles displaying the IgG-binding domains D and E of Staphylococcus aureus protein A (PA) on every coat protein (CP) subunit (TVCVPA) were purified from plants via optimized and new protocols. The latter used polyethylene glycol (PEG) raw precipitates, from which virions were selectively re-solubilized in reverse PEG concentration gradients. This procedure improved the integrity of both TVCVPA and the wild-type subgroup 3 tobamovirus. TVCVPA could be loaded with more than 500 IgGs per virion, which mediated the immunocapture of fluorescent dyes, GFP, and active enzymes. Bi-enzyme ensembles of cooperating glucose oxidase and horseradish peroxidase were tethered together on the TVCVPA carriers via a single antibody type, with one enzyme conjugated chemically to its Fc region, and the other one bound as a target, yielding synthetic multi-enzyme complexes. In microtiter plates, the TVCVPA-displayed sugar-sensing system possessed a considerably increased reusability upon repeated testing, compared to the IgG-bound enzyme pair in the absence of the virus. A high coverage of the viral adapters was also achieved on Ta2O5 sensor chip surfaces coated with a polyelectrolyte interlayer, as a prerequisite for durable TVCVPA-assisted electrochemical biosensing via modularly IgG-assembled sensor enzymes.},
  language  = {en}
}
@inproceedings{BuniatyanHuckPoghossianetal.2014,
  author    = {Buniatyan, V. V. and Huck, Christina and Poghossian, Arshak and Sch{\"o}ning, Michael Josef and Rustamyan, L. G. and Hovnikyan, H. H.},
  title     = {Equivalent circuit and optimization of impedance characteristics of an electrolyte conductivity sensor},
  series = {Proceedings of State Engineering University Armenia : Series Information technologies, electronics, radio engineering},
  volume    = {Iss. 17},
  booktitle = {Proceedings of State Engineering University Armenia : Series Information technologies, electronics, radio engineering},
  number    = {No. 1},
  pages     = {69 -- 76},
  year      = {2014},
  language  = {en}
}
@article{TurekKeusgenPoghossianetal.2008,
  author    = {Turek, M. and Keusgen, M. and Poghossian, Arshak and Mulchandani, A. and Wang, J. and Sch{\"o}ning, Michael Josef},
  title     = {Enzyme-modified electrolyte-insulator-semiconductor sensors},
  series = {Journal of Contemporary Physics. 43 (2008), H. 2},
  journal   = {Journal of Contemporary Physics. 43 (2008), H. 2},
  isbn      = {1934-9378},
  pages     = {82 -- 85},
  year      = {2008},
  language  = {en}
}
@article{KatzPoghossianSchoening2017,
  author    = {Katz, Evgeny and Poghossian, Arshak and Sch{\"o}ning, Michael Josef},
  title     = {Enzyme-based logic gates and circuits - analytical applications and interfacing with electronics},
  series = {Analytical and Bioanalytical Chemistry},
  volume    = {409},
  journal   = {Analytical and Bioanalytical Chemistry},
  publisher = {Springer},
  address   = {Berlin},
  issn      = {1618-2650},
  doi       = {10.1007/s00216-016-0079-7},
  pages     = {81 -- 94},
  year      = {2017},
  abstract  = {The paper is an overview of enzyme-based logic gates and their short circuits, with specific examples of Boolean AND and OR gates, and concatenated logic gates composed of multi-step enzyme-biocatalyzed reactions. Noise formation in the biocatalytic reactions and its decrease by adding a "filter" system, converting convex to sigmoid response function, are discussed. Despite the fact that the enzyme-based logic gates are primarily considered as components of future biomolecular computing systems, their biosensing applications are promising for immediate practical use. Analytical use of the enzyme logic systems in biomedical and forensic applications is discussed and exemplified with the logic analysis of biomarkers of various injuries, e.g., liver injury, and with analysis of biomarkers characteristic of different ethnicity found in blood samples on a crime scene. Interfacing of enzyme logic systems with modified electrodes and semiconductor devices is discussed, giving particular attention to the interfaces functionalized with signal-responsive materials. Future perspectives in the design of the biomolecular logic systems and their applications are discussed in the conclusion.},
  language  = {en}
}
@incollection{SchoeningPoghossian2018,
  author    = {Sch{\"o}ning, Michael Josef and Poghossian, Arshak},
  title     = {Enzyme und Biosensorik},
  series = {Einf{\"u}hrung in die Enzymtechnologie},
  booktitle = {Einf{\"u}hrung in die Enzymtechnologie},
  publisher = {Springer Spektrum},
  address   = {Berlin},
  isbn      = {978-3-662-57619-9},
  doi       = {10.1007/978-3-662-57619-9_18},
  pages     = {323 -- 347},
  year      = {2018},
  abstract  = {Enzymbasierte Biosensoren finden seit mehr als f{\"u}nf Jahrzehnten einen prosperierenden Wachstumsmarkt und werden zunehmend auch in biotechnologischen Prozessen eingesetzt. In diesem Kapitel werden, ausgehend vom Sensorbegriff und typischen Kenngr{\"o}ßen f{\"u}r Biosensoren (Abschn. 18.1), elektrochemische Enzym-Biosensoren vorgestellt und deren typischen Einsatzgebiete diskutiert (Abschn. 18.2). Ein Blick {\"u}ber den „Tellerrand" hinaus zeigt alternative Transduktorprinzipien (Abschn. 18.3) und f{\"u}hrt abschließend in aktuelle Forschungstrends ein (Abschn. 18.4).},
  language  = {de}
}
@article{PoghossianKatzSchoening2015,
  author    = {Poghossian, Arshak and Katz, Evgeny and Sch{\"o}ning, Michael Josef},
  title     = {Enzyme logic AND-Reset and OR-Reset gates based on a field-effect electronic transducer modified with multi-enzyme membrane},
  series = {Chemical Communications},
  volume    = {51},
  journal   = {Chemical Communications},
  publisher = {Royal Society of Chemistry (RSC)},
  address   = {Cambridge},
  doi       = {10.1039/C5CC01362C},
  pages     = {6564 -- 6567},
  year      = {2015},
  abstract  = {Capacitive field-effect sensors modified with a multi-enzyme membrane have been applied for an electronic transduction of biochemical signals processed by enzyme-based AND-Reset and OR-Reset logic gates. The local pH change at the sensor surface induced by the enzymatic reaction was used for the activation of the Reset function for the first time.},
  language  = {en}
}