@inproceedings{PaslighFunkeRoethetal.2010,
  author    = {Pasligh, N. and Funke, D. and R{\"o}th, Thilo and Krack, R.},
  title     = {Leichtbau Quertrager als Stahlblech-Aluminiumdruckguss-Hybrid - Von der numerischen Berechnung bis zum realen Prototypen},
  series = {VDI BERICHTE},
  booktitle = {VDI BERICHTE},
  publisher = {VDI Verlag},
  address   = {D{\"u}sseldorf},
  isbn      = {978-3-18-092107-5},
  pages     = {688 Seiten},
  year      = {2010},
  language  = {de}
}
@book{Hoehne2010,
  author    = {H{\"o}hne, Tim},
  title     = {Einfl{\"u}sse von Make or Buy-Entscheidungen auf die Termintreue},
  publisher = {Apprimus Verl.},
  address   = {Aachen},
  isbn      = {978-3-940565-64-8},
  pages     = {XIII, 252 S. : Ill., graph. Darst},
  year      = {2010},
  language  = {de}
}
@article{RossPlummerRodeetal.2010,
  author    = {Ross, Jillian and Plummer, Simon M. and Rode, Anja and Scheer, Nico and Bower, Conrad C. and Vogel, Ortwin and Henderson, Colin J. and Wolf, C. Roland and Elcombe, Clifford R.},
  title     = {Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogens phenobarbital and chlordane in vivo},
  series = {Toxicological Sciences},
  volume    = {116},
  journal   = {Toxicological Sciences},
  number    = {2},
  publisher = {Oxford University Press},
  address   = {Oxford},
  issn      = {1096-0929},
  doi       = {10.1093/toxsci/kfq118},
  pages     = {452 -- 466},
  year      = {2010},
  abstract  = {Mouse nongenotoxic hepatocarcinogens phenobarbital (PB) and chlordane induce hepatomegaly characterized by hypertrophy and hyperplasia. Increased cell proliferation is implicated in the mechanism of tumor induction. The relevance of these tumors to human health is unclear. The xenoreceptors, constitutive androstane receptors (CARs), and pregnane X receptor (PXR) play key roles in these processes. Novel "humanized" and knockout models for both receptors were developed to investigate potential species differences in hepatomegaly. The effects of PB (80 mg/kg/4 days) and chlordane (10 mg/kg/4 days) were investigated in double humanized PXR and CAR (huPXR/huCAR), double knockout PXR and CAR (PXRKO/CARKO), and wild-type (WT) C57BL/6J mice. In WT mice, both compounds caused increased liver weight, hepatocellular hypertrophy, and cell proliferation. Both compounds caused alterations to a number of cell cycle genes consistent with induction of cell proliferation in WT mice. However, these gene expression changes did not occur in PXRKO/CARKO or huPXR/huCAR mice. Liver hypertrophy without hyperplasia was demonstrated in the huPXR/huCAR animals in response to both compounds. Induction of the CAR and PXR target genes, Cyp2b10 and Cyp3a11, was observed in both WT and huPXR/huCAR mouse lines following treatment with PB or chlordane. In the PXRKO/CARKO mice, neither liver growth nor induction of Cyp2b10 and Cyp3a11 was seen following PB or chlordane treatment, indicating that these effects are CAR/PXR dependent. These data suggest that the human receptors are able to support the chemically induced hypertrophic responses but not the hyperplastic (cell proliferation) responses. At this time, we cannot be certain that hCAR and hPXR when expressed in the mouse can function exactly as the genes do when they are expressed in human cells. However, all parameters investigated to date suggest that much of their functionality is maintained.},
  language  = {en}
}
@article{ScheerRossKapelyukhetal.2010,
  author    = {Scheer, Nico and Ross, Jillian and Kapelyukh, Yury and Rode, Anja and Wolf, C. Roland},
  title     = {In vivo responses of the human and murine pregnane X receptor to dexamethasone in mice},
  series = {Drug Metabolism and Disposition},
  volume    = {38},
  journal   = {Drug Metabolism and Disposition},
  number    = {7},
  publisher = {ASPET},
  address   = {Bethesda},
  issn      = {1521-009X},
  doi       = {10.1124/dmd.109.031872},
  pages     = {1046 -- 1053},
  year      = {2010},
  abstract  = {Dexamethasone (DEX) is a potent and widely used anti-inflammatory and immunosuppressant glucocorticoid. It can bind and activate the pregnane X receptor (PXR), which plays a critical role as xenobiotic sensor in mammals to induce the expression of many enzymes, including cytochromes P450 in the CYP3A family. This induction results in its own metabolism. We have used a series of transgenic mouse lines, including a novel, improved humanized PXR line, to compare the induction profile of PXR-regulated drug-metabolizing enzymes after DEX administration, as well as looking at hepatic responses to rifampicin (RIF). The new humanized PXR model has uncovered further intriguing differences between the human and mouse receptors in that RIF only induced Cyp2b10 in the new humanized model. DEX was found to be a much more potent inducer of Cyp3a proteins in wild-type mice than in mice humanized for PXR. To assess whether PXR is involved in the detoxification of DEX in the liver, we analyzed the consequences of high doses of the glucocorticoid on hepatotoxicity on different PXR genetic backgrounds. We also studied these effects in an additional mouse model in which functional mouse Cyp3a genes have been deleted. These strains exhibited different sensitivities to DEX, indicating a protective role of the PXR and CYP3A proteins against the hepatotoxicity of this compound.},
  language  = {en}
}
@article{AkimbekovZhubanovaMansurovetal.2010,
  author    = {Akimbekov, Nuraly S. and Zhubanova, A. A. and Mansurov, Z. A. and Digel, Ilya and Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l},
  title     = {Use of Carbonized Rise Shell for the local treatment of wounds},
  series = {Eurasian ChemTech Journal},
  volume    = {12},
  journal   = {Eurasian ChemTech Journal},
  number    = {2},
  publisher = {Institute of Combustion Problems},
  address   = {Almaty},
  issn      = {2522-4867},
  doi       = {10.18321/ectj35},
  pages     = {133 -- 138},
  year      = {2010},
  abstract  = {On the model of musculocutaneous wound in rats, the effect of applicative sorption by carbonized rise shell (CRS) on the healing of festering wound was studied. It has been shown, that cytological changes end with rapid scar formation. The use of CRS at the period of severe purulent wound contributes to its favorable course, prevents the development of complications of the animals from sepsis.},
  language  = {en}
}
@book{Matcha2010,
  author    = {Matcha, Heike},
  title     = {Therme mit G{\"a}stehaus : Masterentwurf WS 2009/2010},
  publisher = {Technische Universit{\"a}t Darmstadt},
  address   = {Darmstadt},
  isbn      = {978-3-88536-115-2},
  pages     = {75 S. : {\"u}berw. Ill},
  year      = {2010},
  language  = {de}
}
@book{Matcha2010,
  author    = {Matcha, Heike},
  title     = {Konzerthaus in Stralsund : Masterentwurf SS 2009},
  publisher = {Technische Universit{\"a}t Darmstadt},
  address   = {Darmstadt},
  isbn      = {978-3-88536-114-5},
  pages     = {83 S. : {\"u}berw. Ill.},
  year      = {2010},
  language  = {de}
}
@book{Matcha2010,
  author    = {Matcha, Heike},
  title     = {Lamborghini an der Spree : Masterentwurf WS 2008/2009},
  publisher = {Technische Universit{\"a}t Darmstadt},
  address   = {Darmstadt},
  isbn      = {978-3-88536-113-8},
  pages     = {65 S. : {\"u}berw. Ill.},
  year      = {2010},
  language  = {de}
}
@book{MatchaQuastenRabighomi2010,
  author    = {Matcha, Heike and Quasten, Gero and Rabighomi, Hossein},
  title     = {Qualit{\"a}tssteigerung im verdichteten Wohnungsbau {\"u}ber Erzeugung gr{\"o}ßerer Vielfalt und Flexibilit{\"a}t durch individualisierte Massenfertigung am Beispiel gestapelter Reihenh{\"a}user},
  publisher = {Fraunhofer IRB Verlag},
  address   = {Stuttgart},
  isbn      = {978-3-8167-8216-2},
  pages     = {171 S. : graph. Darst.},
  year      = {2010},
  language  = {de}
}
@incollection{Matcha2010,
  author    = {Matcha, Heike},
  title     = {Regelbasierte Planung - Parametrik},
  series = {Digitale Prozesse: Planung, Gestaltung, Fertigung},
  booktitle = {Digitale Prozesse: Planung, Gestaltung, Fertigung},
  editor    = {Hauschild, Moritz and Karzel, R{\"u}diger},
  publisher = {Ed. Detail},
  address   = {M{\"u}nchen},
  isbn      = {978-3-920034-35-5},
  pages     = {24 -- 24},
  year      = {2010},
  language  = {de}
}
@incollection{Matcha2010,
  author    = {Matcha, Heike},
  title     = {Regelbasierte Planung - Parametrik},
  series = {Digitale Prozesse : Planung, Gestaltung, Fertigung},
  booktitle = {Digitale Prozesse : Planung, Gestaltung, Fertigung},
  editor    = {Hauschild, Moritz and Karzel, R{\"u}diger},
  publisher = {Detail},
  address   = {M{\"u}nchen},
  isbn      = {978-3-95553-022-8},
  doi       = {10.11129/detail.9783955530228},
  pages     = {24 -- 24},
  year      = {2010},
  language  = {de}
}
@book{Matcha2010,
  author    = {Matcha, Heike},
  title     = {Expo 15 : Experimental Parametric Object ; Realisierung des Messestandes "Digital Origami" f{\"u}r den Fachbereich Architektur der Technischen Universit{\"a}t Darmstadt},
  publisher = {Technische Universit{\"a}t Darmstadt},
  address   = {Darmstadt},
  pages     = {54 S. : Ill.},
  year      = {2010},
  language  = {de}
}
@inproceedings{MatchaLjubas2010,
  author    = {Matcha, Heike and Ljubas, Ante},
  title     = {Parametric Origami: Adaptable temporary buildings},
  series = {Future cities: 28th eCAADe Conference Proceedings. eCAADe: Conferences. Zurich, Switzerland},
  booktitle = {Future cities: 28th eCAADe Conference Proceedings. eCAADe: Conferences. Zurich, Switzerland},
  isbn      = {978-0-9541183-7-2},
  pages     = {243 -- 251},
  year      = {2010},
  language  = {en}
}
@techreport{TemizArtmann2010,
  author    = {Temiz Artmann, Ayseg{\"u}l},
  title     = {Fr{\"u}hgeburtenrate mindern durch ein Prognoseverfahren f{\"u}r den vorzeitigen Blasensprung - PROMPT (Premature rupture of membranes prediction test) : Abschlussbericht ; Laufzeit des Vorhabens: 01.03.2007 - 31.12.2009},
  publisher = {Technische Informationsbibliothek u. Universit{\"a}tsbibliothek},
  address   = {Aachen},
  doi       = {10.2314/GBV:644277858},
  year      = {2010},
  language  = {de}
}
@article{TippkoetterRoikaewUlberetal.2010,
  author    = {Tippk{\"o}tter, Nils and Roikaew, Wipa and Ulber, Roland and Hoffmann, Alexander and Denzler, Hans-J{\"o}rg and Buchholz, Heinrich},
  title     = {Paracoccus denitrificans for the effluent recycling during continuous denitrification of liquid food},
  series = {Biotechnology Progress},
  volume    = {26},
  journal   = {Biotechnology Progress},
  number    = {3},
  publisher = {Wiley},
  address   = {Hoboken, NJ},
  issn      = {8756-7938},
  doi       = {10.1002/btpr.384},
  pages     = {756 -- 762},
  year      = {2010},
  abstract  = {Nitrate is an undesirable component of several foods. A typical case of contamination with high nitrate contents is whey concentrate, containing nitrate in concentrations up to 25 l. The microbiological removal of nitrate by Paracoccus denitrificans under formation of harmless nitrogen in combination with a cell retention reactor is described here. Focus lies on the resource-conserving design of a microbal denitrification process. Two methods are compared. The application of polyvinyl alcohol-immobilized cells, which can be applied several times in whey feed, is compared with the implementation of a two step denitrification system. First, the whey concentrate's nitrate is removed by ion exchange and subsequently the eluent regenerated by microorganisms under their retention by crossflow filtration. Nitrite and nitrate concentrations were determined by reflectometric color measurement with a commercially available Reflectoquant® device. Correction factors for these media had to be determined. During the pilot development, bioreactors from 4 to 250 mg·L-1 and crossflow units with membrane areas from 0.02 to 0.80 m2 were examined. Based on the results of the pilot plants, a scaling for the exemplary process of denitrifying 1,000 tons per day is discussed.},
  language  = {en}
}
@article{SiekerNeunerDimitrovaetal.2010,
  author    = {Sieker, Tim and Neuner, Andreas and Dimitrova, Darina and Tippk{\"o}tter, Nils and Bart, Hans-J{\"o}rg and Heinzle, Elmar and Ulber, Roland},
  title     = {Grassilage als Rohstoff f{\"u}r die chemische Industrie},
  series = {Chemie Ingenieur Technik},
  volume    = {82},
  journal   = {Chemie Ingenieur Technik},
  number    = {8, Special Issue: Industrielle Nutzung nachwachsender Rohstoffe},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {1522-2640},
  doi       = {10.1002/cite.201000088},
  pages     = {1153 -- 1159},
  year      = {2010},
  abstract  = {Grassilage stellt einen nachwachsenden Rohstoff mit großem Potenzial dar. Neben Cellulose und Hemicellulose enth{\"a}lt sie auch organische S{\"a}uren, insbesondere Milchs{\"a}ure. In einem Bioraffinerie-Projekt wird die Milchs{\"a}ure aus der Silage isoliert und mit gentechnisch optimierten St{\"a}mmen zu L-Lysin weiterverarbeitet. Die Lignocellulose wird hydrolysiert und zu Ethanol fermentiert. Ein besonderes Augenmerk liegt auf der Integration der unterschiedlichen Prozesse sowie der einzelnen Prozessschritte zu einem Gesamtprozess, der s{\"a}mtliche Inhaltsstoffe der Silage verwertet.},
  language  = {de}
}
@article{UlberPothMonzonetal.2010,
  author    = {Ulber, Roland and Poth, Sebastian and Monzon, Magaly and Tippk{\"o}tter, Nils},
  title     = {Prozessintegration von Hydrolyse und Fermentation von Cellulose- Faserstoff},
  series = {Chemie Ingenieur Technik},
  volume    = {82},
  journal   = {Chemie Ingenieur Technik},
  number    = {1-2},
  issn      = {1522-2640},
  doi       = {10.1002/cite.200900103},
  pages     = {135 -- 139},
  year      = {2010},
  abstract  = {Ein viel versprechender erneuerbarer Rohstoff f{\"u}r die Produktion von Chemikalien und Treibstoffen ist Lignocellulose aus pflanzlicher Biomasse. Die darin enthaltenen Zucker k{\"o}nnen mittels enzymatischer Hydrolyse freigesetzt und fermentativ zu Ethanol umgesetzt werden. Ein interessanter Ansatz ist dabei die simultane Verzuckerung und Fermentation. Hefen und Enzyme haben mit 30 °C bzw. 50 °C zwar unterschiedliche Temperaturoptima, es konnte aber gezeigt werden, dass auch bei den niedrigeren Temperaturen eine Umsetzung der Cellulose zu Glucose erfolgt, wenn auch langsamer als bei optimalen Bedingungen. Außerdem konnte in Vorversuchen gezeigt werden, dass Ethanol in den zu erwartenden Konzentrationen keinen Einfluss auf die enzymatische Umsetzung hat.},
  language  = {de}
}
@incollection{MufflerTippkoetterUlber2010,
  author    = {Muffler, Kai and Tippk{\"o}tter, Nils and Ulber, Roland},
  title     = {Chemical feedstocks and fine chemicals from other substrates},
  series = {Handbook of hydrocarbon and lipid microbiology. Volume 4: Consequences of microbial interactions with hydrocarbons, oils and lipids. - (Springer reference)},
  booktitle = {Handbook of hydrocarbon and lipid microbiology. Volume 4: Consequences of microbial interactions with hydrocarbons, oils and lipids. - (Springer reference)},
  editor    = {Timmis, Kenneth N.},
  publisher = {Springer},
  address   = {Berlin [u.a.]},
  isbn      = {978-3-540-77588-1},
  doi       = {10.1007\%2F978-3-540-77587-4_214},
  pages     = {2891 -- 2902},
  year      = {2010},
  language  = {en}
}
@book{Tippkoetter2010,
  author    = {Tippk{\"o}tter, Nils},
  title     = {Reaktionssysteme zur Aufarbeitung und Umsetzung nachwachsender Rohstoffe : Einsatz chromatographischer Verfahren sowie Membran- und Festbettreaktoren zur Verarbeitung von Molke, St{\"a}rke und Cellulose},
  publisher = {Logos-Verlag},
  address   = {Berlin},
  isbn      = {978-3-8325-2717-4},
  pages     = {III, 269 Seiten},
  year      = {2010},
  language  = {de}
}
@inproceedings{PothMonzonTippkoetteretal.2010,
  author    = {Poth, Sebastian and Monzon, Magaly and Tippk{\"o}tter, Nils and Ulber, Roland},
  title     = {Lignocellulosic biorefinery : process integration of hydrolysis and fermentation},
  series = {Proceedings / 11th European Workshop on Lignocellulosics and Pulp : August 16 - 19, 2010, Hamburg, Germany},
  booktitle = {Proceedings / 11th European Workshop on Lignocellulosics and Pulp : August 16 - 19, 2010, Hamburg, Germany},
  publisher = {vTi},
  address   = {Hamburg},
  pages     = {65 -- 68},
  year      = {2010},
  language  = {en}
}