@misc{HeuermannHueningWache2018, author = {Heuermann, Holger and H{\"u}ning, Felix and Wache, Franz-Josef}, title = {Bussystem sowie Kommunikationsverfahren}, year = {2018}, abstract = {Die Erfindung betrifft ein Bussystem enthaltend Busleitungen, an denen eine Anzahl von Busteilnehmern {\"u}ber einen Transceiver anschließbar sind, wobei der Transceiver eine bidirektionale Kommunikation zwischen mindestens zwei Busteilnehmern bewirkt, wobei auf einer busabgewandten Seite des Transceivers sich an denselben eine Zwischenbr{\"u}ckeneinheit anschließt, die mindestens zwei Sender-/Empf{\"a}nger-Paare enthaltend jeweils einen Sender und einen Empf{\"a}nger aufweist, wobei der Sender einen Senderoszillator, eine Amplituden- und/oder Phasen- und/oder Frequenzmodulator sowie eine Antenne aufweist und wobei der Empf{\"a}nger einen Mischer aufweisenden Demodulator sowie eine Antenne aufweist, wobei ein erstes Sender-/Empf{\"a}nger-Paar {\"u}ber eine Funkschnittstelle mit dem zweiten Sender-/Empf{\"a}nger-Paar miteinander gekoppelt sind.}, language = {de} } @article{KoenigWolf2018, author = {K{\"o}nig, Johannes Alexander and Wolf, Martin R.}, title = {GHOST: An Evaluated Competence Developing Game for Cybersecurity Awareness Training}, series = {International Journal on Advances in Security}, volume = {11}, journal = {International Journal on Advances in Security}, number = {3 \& 4}, publisher = {IARIA Journals}, issn = {1942-2636}, pages = {274 -- 287}, year = {2018}, abstract = {To train end users how to interact with digital systems is indispensable to ensure a strong computer security. 'Competence Developing Game'-based approaches are particularly suitable for this purpose because of their motivation-and simulation-aspects. In this paper the Competence Developing Game 'GHOST' for cybersecurity awareness trainings and its underlying patterns are described. Accordingly, requirements for an 'Competence Developing Game' based training are discussed. Based on these requirements it is shown how a game can fulfill these requirements. A supplementary game interaction design and a corresponding evaluation study is shown. The combination of training requirements and interaction design is used to create a 'Competence Developing Game'-based training concept. A part of these concept is implemented into a playable prototype that serves around one hour of play respectively training time. This prototype is used to perform an evaluation of the game and training aspects of the awareness training. Thereby, the quality of the game aspect and the effectiveness of the training aspect are shown.}, language = {en} } @inproceedings{BungValeroHermens2018, author = {Bung, Daniel Bernhard and Valero, Daniel and Hermens, G.}, title = {Hybrid investigation on the hydraulic performance of a new trapezoidal fishway}, series = {7th IAHR International Symposium on Hydraulic Structures, ISHS 2018}, booktitle = {7th IAHR International Symposium on Hydraulic Structures, ISHS 2018}, isbn = {978-069213277-7}, doi = {10.15142/T3S06R}, pages = {184 -- 193}, year = {2018}, language = {de} } @inproceedings{AlhwarinFerreinScholl2018, author = {Alhwarin, Faraj and Ferrein, Alexander and Scholl, Ingrid}, title = {CRVM: Circular Random Variable-based Matcher - A Novel Hashing Method for Fast NN Search in High-dimensional Spaces}, series = {Proceedings of the 7th International Conference on Pattern Recognition Applications and Methods, ICPRAM 2018}, booktitle = {Proceedings of the 7th International Conference on Pattern Recognition Applications and Methods, ICPRAM 2018}, isbn = {978-989-758-276-9}, doi = {10.5220/0006692802140221}, pages = {214 -- 221}, year = {2018}, language = {en} } @inproceedings{AlhwarinSchifferFerreinetal.2018, author = {Alhwarin, Faraj and Schiffer, Stefan and Ferrein, Alexander and Scholl, Ingrid}, title = {Optimized KinectFusion Algorithm for 3D Scanning Applications}, series = {Proceedings of the 11th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 2: BIOIMAGING}, booktitle = {Proceedings of the 11th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 2: BIOIMAGING}, isbn = {978-989-758-278-3}, doi = {10.5220/0006594700500057}, pages = {50 -- 57}, year = {2018}, language = {en} } @incollection{GollandBaumHammingeretal.2018, author = {Golland, Alexander and Baum, Michael and Hamminger, Alexander and Olbertz, Klaus}, title = {Ein {\"U}berblick: Umsetzung der Datenschutz-Grundverordnung}, series = {Das neue Datenschutzrecht in der Praxis des Steuerberaters Beitragssammlung}, booktitle = {Das neue Datenschutzrecht in der Praxis des Steuerberaters Beitragssammlung}, publisher = {NWB Verlag}, address = {Herne}, isbn = {978-3-482-67271-2}, pages = {8 -- 14}, year = {2018}, abstract = {Datenschutz und der 25.5.2018, wie ein Damoklesschwert scheinen beide Begriffe zurzeit im Raum zu stehe. Jeder weiß oder sollte zumindest um das Inkrafttreten der europ{\"a}ischen DSGVO am 25.5.2018 wissen. Viel wurde {\"u}ber wesentliche Neuerungen im Datenschutzrecht berichtet. Nicht zuletzt {\"u}ber gesteigerte organisatorische Anforderungen, Dokumentationspflichten und drohende Bußgelder. Doch was bedeuten diese Neuerungen ganz konkret f{\"u}r die Praxis des Steuerberaters? Anders als man vermuten k{\"o}nnte, werden die datenschutzrechtlichen Neuerungen nicht nur im Bereich der Kanzleiorganisation relevant. Auch im Steuerverwaltungsverfahren sieht sich der Steuerberater datenschutzrechtlichen Fragestellungen gegen{\"u}ber, bspw. dann, wenn die Finanzbeh{\"o}rden bei der Verarbeitung der personenbezogenen Daten des Mandanten gegen die DSGVO verstoßen. Gleiches gilt in Bereichen des Besch{\"a}ftigtendatenschutzes. Sowohl der Kanzleiinhaber selbst, als auch seine Arbeitgeber-Mandanten haben die Vorschriften des Besch{\"a}ftigtendatenschutzes einzuhalten. Der Steuerberater ben{\"o}tigt datenschutzrechtliches Know How, welches unmittelbar seine t{\"a}gliche Praxis betrifft. Andernfalls besteht das Risiko, dass dieser mit mehr Fragen, als Antworten zur{\"u}ck bleibt.}, language = {de} } @article{MolinnusHardtSiegertetal.2018, author = {Molinnus, Denise and Hardt, Gabriel and Siegert, Petra and Willenberg, Holger S. and Poghossian, Arshak and Keusgen, Michael and Sch{\"o}ning, Michael Josef}, title = {Detection of Adrenaline in Blood Plasma as Biomarker for Adrenal Venous Sampling}, series = {Electroanalysis}, volume = {30}, journal = {Electroanalysis}, number = {5}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1521-4109}, doi = {10.1002/elan.201800026}, pages = {937 -- 942}, year = {2018}, abstract = {An amperometric bi-enzyme biosensor based on substrate recycling principle for the amplification of the sensor signal has been developed for the detection of adrenaline in blood. Adrenaline can be used as biomarker verifying successful adrenal venous sampling procedure. The adrenaline biosensor has been realized via modification of a galvanic oxygen sensor with a bi-enzyme membrane combining a genetically modified laccase and a pyrroloquinoline quinone-dependent glucose dehydrogenase. The measurement conditions such as pH value and temperature were optimized to enhance the sensor performance. A high sensitivity and a low detection limit of about 0.5-1 nM adrenaline have been achieved in phosphate buffer at pH 7.4, relevant for measurements in blood samples. The sensitivity of the biosensor to other catecholamines such as noradrenaline, dopamine and dobutamine has been studied. Finally, the sensor has been successfully applied for the detection of adrenaline in human blood plasma.}, language = {en} } @incollection{SchoeningPoghossian2018, author = {Sch{\"o}ning, Michael Josef and Poghossian, Arshak}, title = {Enzyme und Biosensorik}, series = {Einf{\"u}hrung in die Enzymtechnologie}, booktitle = {Einf{\"u}hrung in die Enzymtechnologie}, publisher = {Springer Spektrum}, address = {Berlin}, isbn = {978-3-662-57619-9}, doi = {10.1007/978-3-662-57619-9_18}, pages = {323 -- 347}, year = {2018}, abstract = {Enzymbasierte Biosensoren finden seit mehr als f{\"u}nf Jahrzehnten einen prosperierenden Wachstumsmarkt und werden zunehmend auch in biotechnologischen Prozessen eingesetzt. In diesem Kapitel werden, ausgehend vom Sensorbegriff und typischen Kenngr{\"o}ßen f{\"u}r Biosensoren (Abschn. 18.1), elektrochemische Enzym-Biosensoren vorgestellt und deren typischen Einsatzgebiete diskutiert (Abschn. 18.2). Ein Blick {\"u}ber den „Tellerrand" hinaus zeigt alternative Transduktorprinzipien (Abschn. 18.3) und f{\"u}hrt abschließend in aktuelle Forschungstrends ein (Abschn. 18.4).}, language = {de} } @inproceedings{BlankeDringVonteinetal.2018, author = {Blanke, Tobias and Dring, Bernd and Vontein, Marius and Kuhnhenne, Markus}, title = {Climate Change Mitigation Potentials of Vertical Building Integrated Photovoltaic}, series = {8th International Workshop on Integration of Solar Power into Power Systems : 16-17 October 2018, Stockholm, Sweden}, booktitle = {8th International Workshop on Integration of Solar Power into Power Systems : 16-17 October 2018, Stockholm, Sweden}, pages = {1 -- 7}, year = {2018}, language = {en} } @article{Golland2018, author = {Golland, Alexander}, title = {Gemeinsame Verantwortlichkeit in mehrstufigen Verarbeitungsszenarien}, volume = {21}, number = {7-8}, publisher = {dfv Mediengruppe}, address = {Frankfurt a.M.}, issn = {1434-6354}, pages = {433 -- 438}, year = {2018}, abstract = {Die Rechtsfigur der gemeinsamen Verantwortlichkeit besch{\"a}ftigt die datenschutzrechtliche Literatur seit Langem. Die Bestimmung der Verantwortlichkeit bei arbeitsteiligen Verarbeitungsverfahren, welche vor allem bei heutigen Plattformdiensten {\"u}blich sind, ist komplex: Stets sind mehrere Akteure beteiligt und in der Regel werden durch die Handlung eines Beteiligten mehrere Verarbeitungsschritte ausgel{\"o}st. Nun hat sich der EuGH in einem in mehrfacher Hinsicht bemerkenswerten Urteil ge{\"a}ußert.}, language = {de} } @incollection{FrotscherStaat2018, author = {Frotscher, Ralf and Staat, Manfred}, title = {Towards Patient-Specific Computational Modeling of hiPS-Derived Cardiomyocyte Function and Drug Action}, series = {Biological, Physical and Technical Basics of Cell Engineering}, booktitle = {Biological, Physical and Technical Basics of Cell Engineering}, editor = {Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l and Zhubanova, Azhar A. and Digel, Ilya}, publisher = {Springer}, address = {Singapore}, isbn = {978-981-10-7904-7}, doi = {10.1007/978-981-10-7904-7_10}, pages = {233 -- 250}, year = {2018}, abstract = {Human-induced pluripotent stem cell-derived cardiomyocytes (hiPS-CM) today are widely used for the investigation of normal electromechanical cardiac function, of cardiac medication and of mutations. Computational models are thus established that simulate the behavior of this kind of cells. This section first motivates the modeling of hiPS-CM and then presents and discusses several modeling approaches of microscopic and macroscopic constituents of human-induced pluripotent stem cell-derived and mature human cardiac tissue. The focus is led on the mapping of the computational results one can achieve with these models onto mature human cardiomyocyte models, the latter being the real matter of interest. Model adaptivity is the key feature that is discussed because it opens the way for modeling various biological effects like biological variability, medication, mutation and phenotypical expression. We compare the computational with experimental results with respect to normal cardiac function and with respect to inotropic and chronotropic drug effects. The section closes with a discussion on the status quo of the specificity of computational models and on what challenges have to be solved to reach patient-specificity.}, language = {en} } @inproceedings{FerreinSchifferKallweit2018, author = {Ferrein, Alexander and Schiffer, Stefan and Kallweit, Stephan}, title = {The ROSIN Education Concept - Fostering ROS Industrial-Related Robotics Education in Europe}, series = {ROBOT 2017: Third Iberian Robotics Conference}, booktitle = {ROBOT 2017: Third Iberian Robotics Conference}, publisher = {Springer}, address = {Cham}, isbn = {978-3-319-70836-2}, doi = {10.1007/978-3-319-70836-2_31}, pages = {370 -- 381}, year = {2018}, language = {en} } @incollection{YoshinobuKrauseMiyamotoetal.2018, author = {Yoshinobu, Tatsuo and Krause, Steffi and Miyamoto, Ko-ichiro and Werner, Frederik and Poghossian, Arshak and Wagner, Torsten and Sch{\"o}ning, Michael Josef}, title = {(Bio-)chemical Sensing and Imaging by LAPS and SPIM}, series = {Label-free biosensing: advanced materials, devices and applications}, booktitle = {Label-free biosensing: advanced materials, devices and applications}, publisher = {Springer}, address = {Cham}, isbn = {978-3-319-75219-8}, pages = {103 -- 132}, year = {2018}, abstract = {The light-addressable potentiometric sensor (LAPS) and scanning photo-induced impedance microscopy (SPIM) are two closely related methods to visualise the distributions of chemical species and impedance, respectively, at the interface between the sensing surface and the sample solution. They both have the same field-effect structure based on a semiconductor, which allows spatially resolved and label-free measurement of chemical species and impedance in the form of a photocurrent signal generated by a scanning light beam. In this article, the principles and various operation modes of LAPS and SPIM, functionalisation of the sensing surface for measuring various species, LAPS-based chemical imaging and high-resolution sensors based on silicon-on-sapphire substrates are described and discussed, focusing on their technical details and prospective applications.}, language = {en} } @phdthesis{Bhattarai2018, author = {Bhattarai, Aroj}, title = {Constitutive modeling of female pelvic floor dysfunctions and reconstructive surgeries using prosthetic mesh implants}, isbn = {978-3-9818074-8-6}, doi = {10.17185/duepublico/70340}, pages = {192 S.}, year = {2018}, language = {en} } @inproceedings{RendonDieckmannWeidleetal.2018, author = {Rendon, Carlos and Dieckmann, Simon and Weidle, Mathias and Dersch, J{\"u}rgen and Teixeira Boura, Cristiano Jos{\´e} and Polklas, Thomas and Kuschel, Marcus and Herrmann, Ulf}, title = {Retrofitting of existing parabolic trough collector power plants with molten salt tower systems}, series = {AIP Conference Proceedings}, volume = {2033}, booktitle = {AIP Conference Proceedings}, number = {1}, doi = {10.1063/1.5067030}, pages = {030014-1 -- 030014-8}, year = {2018}, language = {en} } @article{GoettenFingerHavermannetal.2018, author = {G{\"o}tten, Falk and Finger, Felix and Havermann, Marc and Braun, Carsten and Gomez, Francisco and Bill, C.}, title = {On the flight performance impact of landing gear drag reduction methods for unmanned air vehicles}, series = {Deutscher Luft- und Raumfahrtkongress 2018}, journal = {Deutscher Luft- und Raumfahrtkongress 2018}, publisher = {DGLR}, address = {Bonn}, doi = {10.25967/480058}, pages = {11 S.}, year = {2018}, abstract = {The flight performance impact of three different landing gear configurations on a small, fixed-wing UAV is analyzed with a combination of RANS CFD calculations and an incremental flight performance algorithm. A standard fixed landing gear configuration is taken as a baseline, while the influence of retracting the landing gear or applying streamlined fairings is investigated. A retraction leads to a significant parasite drag reduction, while also fairings promise large savings. The increase in lift-to-drag ratio is reduced at high lift coefficients due to the influence of induced drag. All configurations are tested on three different design missions with an incremental flight performance algorithm. A trade-off study is performed using the retracted or faired landing gear's weight increase as a variable. The analysis reveals only small mission performance gains as the aerodynamic improvements are negated by weight penalties. A new workflow for decision-making is presented that allows to estimate if a change in landing gear configuration is beneficial for a small UAV.}, language = {en} } @article{MolinnusHardtKaeveretal.2018, author = {Molinnus, Denise and Hardt, G. and K{\"a}ver, L. and Willenberg, H.S. and Kr{\"o}ger, J.-C. and Poghossian, Arshak and Keusgen, Michael and Sch{\"o}ning, Michael Josef}, title = {Chip-based biosensor for the detection of low adrenaline concentrations to support adrenal venous sampling}, series = {Sensor and Actuators B: Chemical}, volume = {272}, journal = {Sensor and Actuators B: Chemical}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0925-4005}, doi = {10.1016/j.snb.2018.05.136}, pages = {21 -- 27}, year = {2018}, abstract = {A chip-based amperometric biosensor referring on using the bioelectrocatalytical amplification principle for the detection of low adrenaline concentrations is presented. The adrenaline biosensor has been prepared by modification of a platinum thin-film electrode with an enzyme membrane containing the pyrroloquinoline quinone-dependent glucose dehydrogenase and glutaraldehyde. Measuring conditions such as temperature, pH value, and glucose concentration have been optimized to achieve a high sensitivity and a low detection limit of about 1 nM adrenaline measured in phosphate buffer at neutral pH value. The response of the biosensor to different catecholamines has also been proven. Long-term stability of the adrenaline biosensor has been studied over 10 days. In addition, the biosensor has been successfully applied for adrenaline detection in human blood plasma for future biomedical applications. Furthermore, preliminary experiments have been carried to detect the adrenaline-concentration difference measured in peripheral blood and adrenal venous blood, representing the adrenal vein sampling procedure of a physician.}, language = {en} } @incollection{DuongSeifarthTemizArtmannetal.2018, author = {Duong, Minh Tuan and Seifarth, Volker and Temiz Artmann, Ayseg{\"u}l and Artmann, Gerhard and Staat, Manfred}, title = {Growth Modelling Promoting Mechanical Stimulation of Smooth Muscle Cells of Porcine Tubular Organs in a Fibrin-PVDF Scaffold}, series = {Biological, Physical and Technical Basics of Cell Engineering}, booktitle = {Biological, Physical and Technical Basics of Cell Engineering}, editor = {Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l and Zhubanova, Azhar A. and Digel, Ilya}, publisher = {Springer}, address = {Singapore}, isbn = {978-981-10-7904-7}, doi = {10.1007/978-981-10-7904-7_9}, pages = {209 -- 232}, year = {2018}, abstract = {Reconstructive surgery and tissue replacements like ureters or bladders reconstruction have been recently studied, taking into account growth and remodelling of cells since living cells are capable of growing, adapting, remodelling or degrading and restoring in order to deform and respond to stimuli. Hence, shapes of ureters or bladders and their microstructure change during growth and these changes strongly depend on external stimuli such as training. We present the mechanical stimulation of smooth muscle cells in a tubular fibrin-PVDFA scaffold and the modelling of the growth of tissue by stimuli. To this end, mechanotransduction was performed with a kyphoplasty balloon catheter that was guided through the lumen of the tubular structure. The bursting pressure was examined to compare the stability of the incubated tissue constructs. The results showed the significant changes on tissues with training by increasing the burst pressure as a characteristic mechanical property and the smooth muscle cells were more oriented with uniformly higher density. Besides, the computational growth models also exhibited the accurate tendencies of growth of the cells under different external stimuli. Such models may lead to design standards for the better layered tissue structure in reconstructing of tubular organs characterized as composite materials such as intestines, ureters and arteries.}, language = {en} } @article{KochPoghossianSchoeningetal.2018, author = {Koch, Claudia and Poghossian, Arshak and Sch{\"o}ning, Michael Josef and Wege, Christian}, title = {Penicillin Detection by Tobacco Mosaic Virus-Assisted Colorimetric Biosensors}, series = {Nanotheranostics}, volume = {2}, journal = {Nanotheranostics}, number = {2}, publisher = {Ivyspring}, address = {Sydney}, issn = {2206-7418}, doi = {10.7150/ntno.22114}, pages = {184 -- 196}, year = {2018}, abstract = {The presentation of enzymes on viral scaffolds has beneficial effects such as an increased enzyme loading and a prolonged reusability in comparison to conventional immobilization platforms. Here, we used modified tobacco mosaic virus (TMV) nanorods as enzyme carriers in penicillin G detection for the first time. Penicillinase enzymes were conjugated with streptavidin and coupled to TMV rods by use of a bifunctional biotin-linker. Penicillinase-decorated TMV particles were characterized extensively in halochromic dye-based biosensing. Acidometric analyte detection was performed with bromcresol purple as pH indicator and spectrophotometry. The TMV-assisted sensors exhibited increased enzyme loading and strongly improved reusability, and higher analysis rates compared to layouts without viral adapters. They extended the half-life of the sensors from 4 - 6 days to 5 weeks and thus allowed an at least 8-fold longer use of the sensors. Using a commercial budget-priced penicillinase preparation, a detection limit of 100 µM penicillin was obtained. Initial experiments also indicate that the system may be transferred to label-free detection layouts.}, language = {en} } @incollection{KochPoghossianWegeetal.2018, author = {Koch, Claudia and Poghossian, Arshak and Wege, Christina and Sch{\"o}ning, Michael Josef}, title = {TMV-Based Adapter Templates for Enhanced Enzyme Loading in Biosensor Applications}, series = {Virus-Derived Nanoparticles for Advanced Technologies}, booktitle = {Virus-Derived Nanoparticles for Advanced Technologies}, editor = {Wege, Christina}, publisher = {Humana Press}, address = {New York, NY}, isbn = {978-1-4939-7808-3}, doi = {10.1007/978-1-4939-7808-3}, pages = {553 -- 568}, year = {2018}, abstract = {Nanotubular tobacco mosaic virus (TMV) particles and RNA-free lower-order coat protein (CP) aggregates have been employed as enzyme carriers in different diagnostic layouts and compared for their influence on biosensor performance. In the following, we describe a label-free electrochemical biosensor for improved glucose detection by use of TMV adapters and the enzyme glucose oxidase (GOD). A specific and efficient immobilization of streptavidin-conjugated GOD ([SA]-GOD) complexes on biotinylated TMV nanotubes or CP aggregates was achieved via bioaffinity binding. Glucose sensors with adsorptively immobilized [SA]-GOD, and with [SA]-GOD cross-linked with glutardialdehyde, respectively, were tested in parallel on the same sensor chip. Comparison of these sensors revealed that TMV adapters enhanced the amperometric glucose detection remarkably, conveying highest sensitivity, an extended linear detection range and fastest response times. These results underline a great potential of an integration of virus/biomolecule hybrids with electronic transducers for applications in biosensorics and biochips. Here, we describe the fabrication and use of amperometric sensor chips combining an array of circular Pt electrodes, their loading with GOD-modified TMV nanotubes (and other GOD immobilization methods), and the subsequent investigations of the sensor performance.}, language = {en} }