@phdthesis{Schieffer2012, author = {Schieffer, Andre}, title = {Studies on diversity and coexistence in an experimental microbial community}, pages = {76 Bl. : Ill.}, year = {2012}, abstract = {Biodiversity and the coexistence of species have puzzled and fascinated biologists since decades and is a hotspot in todays' natural sciences. Preserving this biodiversity is a great challenge as habitats and environments underlying tremendous changes like climate change and the loss of natural habitats, which are mainly due to anthropogenic influences. The coexistence of numerous species even in homogeneous environments is a stunning feature of natural communities and has been summarized under the term 'paradox of plankton'. Up to now, there are several mechanisms discussed, which may contribute to local and global diversity of organisms. Several interspecific trade offs have been identified maintaining the coexistence of species like their abilities regarding competition and predator avoidance, their capability to disperse in space and time, and their ability to exploit variable resources. Further, micro-evolutionary dynamics supporting the coexistence of species have been added to our knowledge, and deriving from theoretical deterministic models, non-linear dynamics which describe the temporal fluctuation of abundances of organisms. Whereas competition and predation seem to be clue structural elements within interacting organisms, the intrinsic dynamic behavior - by means of temporal changes in abundance - plays an important role regarding coexistence within a community. The present work sheds light on different factors affecting the coexistence of species using experimental microbial model systems consisting of a bacterivorous ciliate as the predator and two bacteria strains as prey organism. Additionally, another experimental setup consisting of two up to five bacteria species competing for one limiting resource was investigated. Highly controllable chemostat systems were established to exclude extrinsic disturbances. According to theoretical analyses I was able to show - experimentally and theoretically - that phenotypic plasticity of one species within a microbial one-predator-two-prey food web enlarges the range of possible coexistence of all species under different dynamic conditions, compared to a food web without phenotypic plasticity. This was accompanied by non-linear (chaotic) population dynamics within all experimental systems showing phenotypic plasticity. The experiments on the interplay of competition, predation and invasion showed that all aspects have an influence on species coexistence. Under undisturbed controlled conditions all aspects were analyzed in detail and in combination. Populations showed oscillations which were shown by quasi-chaotic attractors in phase space diagrams. Competition experiments with two up to five bacteria species competing for one limiting resource showed that all organisms were able to coexist which was mediated by species oscillations entering a regime of chaos. Besides that fact it was found, that the productivity (biomass) as well as the total cell numbers - under the same nutrition supply - increased by an increasing number of species in the experimental systems. Up to now, the occurrence of non-linear dynamics in well controlled experimental studies has been recognized several times and this phenomenon seemed to be more common in natural systems than generally assumed.}, language = {en} } @phdthesis{Geenen2013, author = {Geenen, Eva-Maria}, title = {Studies of Epstein-Barr virus EBNA2 and its interactions with host cell factors}, publisher = {Universit{\´e} de Grenoble}, address = {Grenoble}, pages = {125 S.}, year = {2013}, language = {en} } @article{ZerlinKasischkeDigeletal.2007, author = {Zerlin, Kay and Kasischke, Nicole and Digel, Ilya and Maggakis-Kelemen, Christina and Temiz Artmann, Ayseg{\"u}l and Porst, Dariusz and Kayser, Peter and Linder, Peter and Artmann, Gerhard}, title = {Structural transition temperature of hemoglobins correlates with species' body temperature}, series = {European Biophysics Journal. 37 (2007), H. 1}, journal = {European Biophysics Journal. 37 (2007), H. 1}, isbn = {1432-1017}, pages = {1 -- 10}, year = {2007}, language = {en} } @article{PresslerEsefeldScherretal.2010, author = {Pressler, Axel and Esefeld, Katrin and Scherr, Johannes and Ali, Mohammad and Hanssen, Henner and Kotliar, Konstantin and Lanzl, Ines and Halle, Martin and Kaemmerer, Harald and Schmidt-Trucks{\"a}ss, Arno and Hager, Alfred}, title = {Structural alterations of retinal arterioles in adults late after repair of aortic isthmic coarctation}, series = {The American Journal of Cardiology}, volume = {105}, journal = {The American Journal of Cardiology}, number = {5}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0002-9149}, doi = {10.1016/j.amjcard.2009.10.070}, pages = {740 -- 744}, year = {2010}, abstract = {Patients after coarctation repair still have an increased risk of cardiovascular or cerebrovascular events. This has been explained by the persisting hypertension and alterations in the peripheral vessels. However, involvement of the central vessels such as the retinal arteries is virtually unknown. A total of 34 patients after coarctation repair (22 men and 12 women; 23 to 58 years old, age range 0 to 32 years at surgical repair) and 34 nonhypertensive controls underwent structural and functional retinal vessel analysis. Using structural analysis, the vessel diameters were measured. Using functional analysis, the endothelium-dependent vessel dilation in response to flicker light stimulation was assessed. In the patients after coarctation repair, the retinal arteriolar diameter was significantly reduced compared to that of the controls (median 182 μm, first to third quartile 171 to 197; vs 197 μm, first to third quartile 193 to 206; p <0.001). These findings were independent of the peripheral blood pressure and age at intervention. No differences were found for venules. The functional analysis findings were not different between the patients and controls (maximum dilation 3.5\%, first to third quartile 2.1\% to 4.5\% vs 3.6\%, first to third quartile 2.2\% to 4.3\%; p = 0.81), indicating preserved autoregulative mechanisms. In conclusion, the retinal artery diameter is reduced in patients after coarctation repair, independent of their current blood pressure level and age at intervention. As a structural marker of chronic vessel damage associated with past, current, or future hypertension, retinal arteriolar narrowing has been linked to stroke incidence. These results indicate an involvement of cerebral microcirculation in aortic coarctation, despite timely repair, and might contribute to explain the increased rate of cerebrovascular events in such patients.}, language = {en} } @article{FrotscherStaat2014, author = {Frotscher, Ralf and Staat, Manfred}, title = {Stresses produced by different textile mesh implants in a tissue equivalent}, series = {BioNanoMaterials}, volume = {15}, journal = {BioNanoMaterials}, number = {1-2}, publisher = {De Gruyter}, address = {Berlin}, issn = {2191-4672 (E-Journal); 2193-066X (E-Journal); 0011-8656 (Print); 1616-0177 (Print); 2193-0651 (Print)}, doi = {10.1515/bnm-2014-0003}, pages = {25 -- 30}, year = {2014}, abstract = {Two single-incision mini-slings used for treating urinary incontinence in women are compared with respect to the stresses they produce in their surrounding tissue. In an earlier paper we experimentally observed that these implants produce considerably different stress distributions in a muscle tissue equivalent. Here we perform 2D finite element analyses to compare the shear stresses and normal stresses in the tissue equivalent for the two meshes and to investigate their failure behavior. The results clearly show that the Gynecare TVT fails for increasing loads in a zipper-like manner because it gradually debonds from the surrounding tissue. Contrary to that, the tissue at the ends of the DynaMesh-SIS direct may rupture but only at higher loads. The simulation results are in good agreement with the experimental observations thus the computational model helps to interpret the experimental results and provides a tool for qualitative evaluation of mesh implants.}, language = {en} } @inproceedings{StaatTran2022, author = {Staat, Manfred and Tran, Ngoc Trinh}, title = {Strain based brittle failure criteria for rocks}, series = {Proceedings of (NACOME2022) The 11th National Conference on Mechanics, Vol. 1. Solid Mechanics, Rock Mechanics, Artificial Intelligence, Teaching and Training, Hanoi, December 2-3, 2022}, booktitle = {Proceedings of (NACOME2022) The 11th National Conference on Mechanics, Vol. 1. Solid Mechanics, Rock Mechanics, Artificial Intelligence, Teaching and Training, Hanoi, December 2-3, 2022}, publisher = {Nha xuat ban Khoa hoc tu nhien va Cong nghe (Verlag Naturwissenschaft und Technik)}, address = {Hanoi}, isbn = {978-604-357-084-7}, pages = {500 -- 509}, year = {2022}, abstract = {When confining pressure is low or absent, extensional fractures are typical, with fractures occurring on unloaded planes in rock. These "paradox" fractures can be explained by a phenomenological extension strain failure criterion. In the past, a simple empirical criterion for fracture initiation in brittle rock has been developed. But this criterion makes unrealistic strength predictions in biaxial compression and tension. A new extension strain criterion overcomes this limitation by adding a weighted principal shear component. The weight is chosen, such that the enriched extension strain criterion represents the same failure surface as the Mohr-Coulomb (MC) criterion. Thus, the MC criterion has been derived as an extension strain criterion predicting failure modes, which are unexpected in the understanding of the failure of cohesive-frictional materials. In progressive damage of rock, the most likely fracture direction is orthogonal to the maximum extension strain. The enriched extension strain criterion is proposed as a threshold surface for crack initiation CI and crack damage CD and as a failure surface at peak P. Examples show that the enriched extension strain criterion predicts much lower volumes of damaged rock mass compared to the simple extension strain criterion.}, language = {en} } @book{Artmann2011, author = {Artmann, Gerhard}, title = {Stem cell engineering : principles and applications / Gerhard M. Artmann ... eds.}, publisher = {Springer}, address = {Berlin [u.a.]}, isbn = {978-3-642-11864-7}, pages = {XLI, 541 S. : Ill., graph. Darst.}, year = {2011}, language = {en} } @article{KappmeyerKotliarLanzl2009, author = {Kappmeyer, K. and Kotliar, Konstantin and Lanzl, I. M.}, title = {Spielen von Blasinstrumenten und Augeninnendruck}, series = {Zeitschrift f{\"u}r praktische Augenheilkunde \& augen{\"a}rztliche Fortbildung : ZPA}, volume = {Bd. 30}, journal = {Zeitschrift f{\"u}r praktische Augenheilkunde \& augen{\"a}rztliche Fortbildung : ZPA}, issn = {1436-0322}, pages = {169 -- 171}, year = {2009}, language = {de} } @article{TuraliyevaYeshibaevSaparbekovaetal.2016, author = {Turaliyeva, M. and Yeshibaev, A. and Saparbekova, A. and Akynova, L. and Abildayeva, R. and Sadenova, M. and Sartayeva, K. and Schieffer, Andre and Digel, Ilya}, title = {Species composition and injuriousness of stranger xylophilous fauna affecting indigenous urban dendroflora of Central Asia}, series = {Asian journal of microbiology, biotechnology \& environmental sciences : AJMBES}, volume = {18}, journal = {Asian journal of microbiology, biotechnology \& environmental sciences : AJMBES}, number = {2}, publisher = {EM International}, issn = {0972-3005}, pages = {359 -- 366}, year = {2016}, abstract = {At the present time, one of the most serious environmental problems of Central Asia and South Kazakhstan is the ongoing large-scale deterioration of principal urban tree populations. Several major centers of massive spread of invasive plant pests have been found in urban dendroflora of this region. The degree of damage of seven most wide-spread aboriginal tree species was found to range from 21.4±1.1 to 85.4±1.8\%. In particular, the integrity of the native communities of sycamore (Platanus spp.), willow (Salix spp.), poplar (Populus spp.) and elm (Ulmus spp.) is highly endangered. Our taxonomic analysis of the most dangerous tree pests of the region has revealed them as neobiontic xylophilous insects such as Cossus cossus L. (Order: Lepidoptera L.) Monochamus urussovi Fisch., Monochamus sutor L., Acanthocinus aedelis L. and {\~N}etonia aureate L. (Order: Coleoptera L.). We relate the origin of this threatening trend with the import of industrial wood in the mid 90’s of the last century that was associated with high degree of the constructional work in the region. Because of the absence of efficient natural predators of the pest species, the application of microbiological methods of the pest control and limitation is suggested.}, language = {en} } @article{GrundmannDachwaldGrimmetal.2015, author = {Grundmann, Jan Thimo and Dachwald, Bernd and Grimm, Christian D. and Kahle, Ralph and Koch, Aaron Dexter and Krause, Christian and Lange, Caroline and Quantius, Dominik and Ulamec, Stephan}, title = {Spacecraft for Hypervelocity Impact Research - An Overview of Capabilities, Constraints and the Challenges of Getting There}, series = {Procedia Engineering}, volume = {Vol. 103}, journal = {Procedia Engineering}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1877-7058}, doi = {10.1016/j.proeng.2015.04.021}, pages = {151 -- 158}, year = {2015}, language = {en} } @inproceedings{DigelTemizArtmannNojimaetal.2003, author = {Digel, Ilya and Temiz Artmann, Ayseg{\"u}l and Nojima, H. and Artmann, Gerhard}, title = {Some peculiarities of application of cluster ions generated by plasma in respect of indoor air purification :[abstract]}, year = {2003}, abstract = {Recently, the SHARP Corporation, Japan, has developed the world's first "Plasma Cluster Ions (PCI)" air purification technology using plasma discharge to generate cluster ions. The new plasma cluster device releases positive and negative ions into the air, which are able to decompose and deactivate harmful airborne substances by chemical reactions. Because cluster ions consist of positive and negative ions that normally exist in the natural world, they are completely harmless and safe to humans. The amount of ozone generated by cluster ions is less than 0.01 ppm, which is significantly less than the 0.05-ppm standard for industrial operations and consumer electronics. This amount, thus, has no harming effects whatsoever on the human body. But particular properties and chemical processes in PCI treatment are still under study. It has been shown that PCI in most cases show strongly pronounced irreversible killing effects in respect of airborne microflora due to free-radical induced reactions and can be considered as a potent technology to disinfect both home, medical and industrial appliances.}, subject = {Clusterion}, language = {en} } @inproceedings{KonstantinidisKowalskiMartinezetal.2015, author = {Konstantinidis, K. and Kowalski, Julia and Martinez, C. F. and Dachwald, Bernd and Ewerhart, D. and F{\"o}rstner, R.}, title = {Some necessary technologies for in-situ astrobiology on enceladus}, series = {Proceedings of the International Astronautical Congress}, booktitle = {Proceedings of the International Astronautical Congress}, isbn = {978-151081893-4}, pages = {1354 -- 1372}, year = {2015}, language = {en} } @article{Staat2002, author = {Staat, Manfred}, title = {Some Achievements of the European Project LISA for FEM Based Limit and Shakedown Analysis}, series = {Computational mechanics : developments and applications, 2002 : presented at the 2002 ASME Pressure Vessels and Piping Conference, Vancouver, British Columbia, Canada, August 5 - 9. / Badie, N. [ed]}, journal = {Computational mechanics : developments and applications, 2002 : presented at the 2002 ASME Pressure Vessels and Piping Conference, Vancouver, British Columbia, Canada, August 5 - 9. / Badie, N. [ed]}, publisher = {American Society of Mechanical Engineers}, address = {New York}, isbn = {0791846520}, pages = {177 -- 185}, year = {2002}, language = {en} } @inproceedings{PeloniCeriottiDachwald2015, author = {Peloni, Alessandro and Ceriotti, Matteo and Dachwald, Bernd}, title = {Solar-Sailing Trajectory Design for Close-up NEA Observations Mission}, series = {4th IAA Planetary Defense Conference - PDC 2015, 13-17 April 2015, Frascati, Roma, Italy}, booktitle = {4th IAA Planetary Defense Conference - PDC 2015, 13-17 April 2015, Frascati, Roma, Italy}, pages = {21 S.}, year = {2015}, language = {de} } @article{PeloniCeriottiDachwald2016, author = {Peloni, Alessandro and Ceriotti, Matteo and Dachwald, Bernd}, title = {Solar-sail trajectory design for a multiple near-earth-asteroid rendezvous mission}, series = {Journal of Guidance, Control, and Dynamics}, volume = {39}, journal = {Journal of Guidance, Control, and Dynamics}, number = {12}, publisher = {AIAA}, address = {Reston, Va.}, issn = {0731-5090}, doi = {10.2514/1.G000470}, pages = {2712 -- 2724}, year = {2016}, abstract = {The scientific interest for near-Earth asteroids as well as the interest in potentially hazardous asteroids from the perspective of planetary defense led the space community to focus on near-Earth asteroid mission studies. A multiple near-Earth asteroid rendezvous mission with close-up observations of several objects can help to improve the characterization of these asteroids. This work explores the design of a solar-sail spacecraft for such a mission, focusing on the search of possible sequences of encounters and the trajectory optimization. This is done in two sequential steps: a sequence search by means of a simplified trajectory model and a set of heuristic rules based on astrodynamics, and a subsequent optimization phase. A shape-based approach for solar sailing has been developed and is used for the first phase. The effectiveness of the proposed approach is demonstrated through a fully optimized multiple near-Earth asteroid rendezvous mission. The results show that it is possible to visit five near-Earth asteroids within 10 years with near-term solar-sail technology.}, language = {en} } @article{DachwaldSeboldt2008, author = {Dachwald, Bernd and Seboldt, W.}, title = {Solar Sails — Propellantless Propulsion for Near- and Medium-Term Deep-Space Missions / W. Seboldt ; B. Dachwald}, series = {Advanced Propulsion Systems and Technologies, Today to 2020 / Claudio Bruno (ed.) ... - (Progress in Astronautics and Aeronautics Series ; 223)}, journal = {Advanced Propulsion Systems and Technologies, Today to 2020 / Claudio Bruno (ed.) ... - (Progress in Astronautics and Aeronautics Series ; 223)}, publisher = {AIAA}, address = {Reston, Va.}, isbn = {978-1-56347-929-8}, pages = {460 S.}, year = {2008}, language = {en} } @inproceedings{GrundmannBauerBorchersetal.2019, author = {Grundmann, Jan Thimo and Bauer, Wlademar and Borchers, Kai and Dumont, Etienne and Grimm, Christian D. and Ho, Tra-Mi and Jahnke, Rico and Koch, Aaron D. and Lange, Caroline and Maiwald, Volker and Meß, Jan-Gerd and Mikulz, Eugen and Quantius, Dominik and Reershemius, Siebo and Renger, Thomas and Sasaki, Kaname and Seefeldt, Patric and Spietz, Peter and Spr{\"o}witz, Tom and Sznajder, Maciej and Toth, Norbert and Ceriotti, Matteo and McInnes, Colin and Peloni, Alessandro and Biele, Jens and Krause, Christian and Dachwald, Bernd and Hercik, David and Lichtenheldt, Roy and Wolff, Friederike and Koncz, Alexander and Pelivan, Ivanka and Schmitz, Nicole and Boden, Ralf and Riemann, Johannes and Seboldt, Wolfgang and Wejmo, Elisabet and Ziach, Christian and Mikschl, Tobias and Montenegro, Sergio and Ruffer, Michael and Cordero, Federico and Tardivel, Simon}, title = {Solar sails for planetary defense \& high-energy missions}, series = {IEEE Aerospace Conference Proceedings}, booktitle = {IEEE Aerospace Conference Proceedings}, doi = {10.1109/AERO.2019.8741900}, pages = {1 -- 21}, year = {2019}, abstract = {20 years after the successful ground deployment test of a (20 m) 2 solar sail at DLR Cologne, and in the light of the upcoming U.S. NEAscout mission, we provide an overview of the progress made since in our mission and hardware design studies as well as the hardware built in the course of our solar sail technology development. We outline the most likely and most efficient routes to develop solar sails for useful missions in science and applications, based on our developed `now-term' and near-term hardware as well as the many practical and managerial lessons learned from the DLR-ESTEC Gossamer Roadmap. Mission types directly applicable to planetary defense include single and Multiple NEA Rendezvous ((M)NR) for precursor, monitoring and follow-up scenarios as well as sail-propelled head-on retrograde kinetic impactors (RKI) for mitigation. Other mission types such as the Displaced L1 (DL1) space weather advance warning and monitoring or Solar Polar Orbiter (SPO) types demonstrate the capability of near-term solar sails to achieve asteroid rendezvous in any kind of orbit, from Earth-coorbital to extremely inclined and even retrograde orbits. Some of these mission types such as SPO, (M)NR and RKI include separable payloads. For one-way access to the asteroid surface, nanolanders like MASCOT are an ideal match for solar sails in micro-spacecraft format, i.e. in launch configurations compatible with ESPA and ASAP secondary payload platforms. Larger landers similar to the JAXA-DLR study of a Jupiter Trojan asteroid lander for the OKEANOS mission can shuttle from the sail to the asteroids visited and enable multiple NEA sample-return missions. The high impact velocities and re-try capability achieved by the RKI mission type on a final orbit identical to the target asteroid's but retrograde to its motion enables small spacecraft size impactors to carry sufficient kinetic energy for deflection.}, language = {en} } @inproceedings{SeboldtDachwald2003, author = {Seboldt, Wolfgang and Dachwald, Bernd}, title = {Solar sails for near-term advanced scientific deep space missions}, series = {Proceedings of the 8th International Workshop on Combustion and Propulsion}, booktitle = {Proceedings of the 8th International Workshop on Combustion and Propulsion}, pages = {14 Seiten}, year = {2003}, abstract = {Solar sails are propelled in space by reflecting solar photons off large mirroring surfaces, thereby transforming the momentum of the photons into a propulsive force. This innovative concept for low-thrust space propulsion works without any propellant and thus provides a wide range of opportunities for highenergy low-cost missions. Offering an efficient way of propulsion, solar sailcraft could close a gap in transportation options for highly demanding exploration missions within our solar system and even beyond. On December 17th, 1999, a significant step was made towards the realization of this technology: a lightweight solar sail structure with an area of 20 m × 20 m was successfully deployed on ground in a large facility at the German Aerospace Center (DLR) at Cologne. The deployment from a package of 60 cm × 60 cm × 65 cm with a total mass of less than 35 kg was achieved using four extremely light-weight carbon fiber reinforced plastics (CFRP) booms with a specific mass of 100 g/m. The paper briefly reviews the basic principles of solar sails as well as the technical concept and its realization in the ground demonstration experiment, performed in close cooperation between DLR and ESA. Next possible steps are outlined. They could comprise the in-orbit demonstration of the sail deployment on the upper stage of a low-cost rocket and the verification of the propulsion concept by an autonomous and free flying solar sail in the frame of a scientific mission. It is expected that the present design could be extended to sail sizes of about (40 m)2 up to even (70 m)2 without significant mass penalty. With these areas, the maximum achievable thrust at 1 AU would range between 10 and 40 mN - comparable to some electric thrusters. Such prototype sails with a mass between 50 and 150 kg plus a micro-spacecraft of 50 to 250 kg would have a maximum acceleration in the order of 0.1 mm/s2 at 1 AU, corresponding to a maximum ∆V-capability of about 3 km/s per year. Two near/medium-term mission examples to a near-Earth asteroid (NEA) will be discussed: a rendezvous mission and a sample return mission.}, language = {en} } @article{DachwaldSeboldt2005, author = {Dachwald, Bernd and Seboldt, W.}, title = {Solar Sails for Near- and Medium-Term Scientific Deep Space Missions / W. Sebolt ; B. Dachwald}, series = {In-space propulsion : edited book of proceedings of the 10-IWCP, the 10th International Workshop on Combustion and Propulsion held in Lerici, La Spezia, Italy, 21-25 September 2003 / [ed.: Luigi T. DeLuca]}, journal = {In-space propulsion : edited book of proceedings of the 10-IWCP, the 10th International Workshop on Combustion and Propulsion held in Lerici, La Spezia, Italy, 21-25 September 2003 / [ed.: Luigi T. DeLuca]}, publisher = {SP Lab, Politecnico di Milano}, address = {Milano}, pages = {getr. Z{\"a}hlung . Ill.}, year = {2005}, language = {en} } @article{DachwaldKahleWie2006, author = {Dachwald, Bernd and Kahle, Ralph and Wie, Bong}, title = {Solar Sailing Kinetic Energy Impactor (KEI) Mission Design Tradeoffs for Impacting and Deflecting Asteroid 99942 Apophis}, series = {AIAA Guidance, Navigation, and Control Conference \& Exhibit - AIAA Atmospheric Flight Mechanics Conference \& Exhibit - AIAA Modeling and Simulation Technologies Conference \& Exhibit - AIAA/AAS Astrodynamics Specialist Conference \& Exhibit : [21 - 24 August 2006, Keystone, Colorado ; papers]. - (AIAA meeting papers on disc ; [11.]2006,19-20 )}, journal = {AIAA Guidance, Navigation, and Control Conference \& Exhibit - AIAA Atmospheric Flight Mechanics Conference \& Exhibit - AIAA Modeling and Simulation Technologies Conference \& Exhibit - AIAA/AAS Astrodynamics Specialist Conference \& Exhibit : [21 - 24 August 2006, Keystone, Colorado ; papers]. - (AIAA meeting papers on disc ; [11.]2006,19-20 )}, publisher = {American Institute of Aeronautics and Astronautics}, address = {Reston, Va.}, isbn = {1-56347-802-1}, pages = {1 -- 20}, year = {2006}, language = {en} }